Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionDNA-binding transcription repressor activity, RNA polymerase II-specific

ZNF750 ZNF131 ZNF699 ZNF692 ZNF726 ZNF681

2.21e-06320256GO:0001227
GeneOntologyMolecularFunctionDNA-binding transcription repressor activity

ZNF750 ZNF131 ZNF699 ZNF692 ZNF726 ZNF681

2.47e-06326256GO:0001217
GeneOntologyMolecularFunctionDNA-binding transcription factor activity, RNA polymerase II-specific

ZNF750 ZNF131 PLAG1 ZNF699 ZNF555 ZBTB48 ZNF692 ZNF726 ZNF730 ZNF681

3.70e-0614122510GO:0000981
GeneOntologyMolecularFunctionRNA polymerase II transcription regulatory region sequence-specific DNA binding

ZNF750 ZNF131 PLAG1 ZNF699 ZNF555 ZBTB48 ZNF692 ZNF726 ZNF730 ZNF681

4.97e-0614592510GO:0000977
GeneOntologyMolecularFunctionRNA polymerase II cis-regulatory region sequence-specific DNA binding

ZNF750 ZNF131 PLAG1 ZNF699 ZBTB48 ZNF692 ZNF726 ZNF730 ZNF681

1.13e-051244259GO:0000978
GeneOntologyMolecularFunctioncis-regulatory region sequence-specific DNA binding

ZNF750 ZNF131 PLAG1 ZNF699 ZBTB48 ZNF692 ZNF726 ZNF730 ZNF681

1.34e-051271259GO:0000987
GeneOntologyMolecularFunctionDNA-binding transcription activator activity, RNA polymerase II-specific

ZNF750 ZNF131 PLAG1 ZNF699 ZNF726 ZNF681

5.32e-05560256GO:0001228
GeneOntologyMolecularFunctionDNA-binding transcription activator activity

ZNF750 ZNF131 PLAG1 ZNF699 ZNF726 ZNF681

5.65e-05566256GO:0001216
GeneOntologyCellularComponentkinetochore

PHF6 CHAMP1 ZNF692

1.28e-03181253GO:0000776
GeneOntologyCellularComponentchromosomal region

PHF6 ZBTB48 CHAMP1 ZNF692

1.47e-03421254GO:0098687
GeneOntologyCellularComponentcondensed chromosome, centromeric region

PHF6 CHAMP1 ZNF692

1.53e-03193253GO:0000779
DomainZnf_C2H2-like

ZNF750 ZNF131 PLAG1 ZNF699 ZNF555 ZBTB48 CHAMP1 ZNF692 ZNF726 ZNF730 ZNF681

1.18e-097962411IPR015880
DomainZnf_C2H2

ZNF750 ZNF131 PLAG1 ZNF699 ZNF555 ZBTB48 CHAMP1 ZNF692 ZNF726 ZNF730 ZNF681

1.33e-098052411IPR007087
DomainZnF_C2H2

ZNF750 ZNF131 PLAG1 ZNF699 ZNF555 ZBTB48 CHAMP1 ZNF692 ZNF726 ZNF730 ZNF681

1.38e-098082411SM00355
Domain-

ZNF131 PLAG1 ZNF699 ZNF555 ZBTB48 CHAMP1 ZNF692 ZNF726 ZNF730 ZNF681

4.67e-0967924103.30.160.60
DomainZnf_C2H2/integrase_DNA-bd

ZNF131 PLAG1 ZNF699 ZNF555 ZBTB48 CHAMP1 ZNF692 ZNF726 ZNF730 ZNF681

5.76e-096942410IPR013087
DomainZINC_FINGER_C2H2_2

ZNF131 PLAG1 ZNF699 ZNF555 ZBTB48 CHAMP1 ZNF692 ZNF726 ZNF730 ZNF681

1.65e-087752410PS50157
DomainZINC_FINGER_C2H2_1

ZNF131 PLAG1 ZNF699 ZNF555 ZBTB48 CHAMP1 ZNF692 ZNF726 ZNF730 ZNF681

1.69e-087772410PS00028
Domainzf-C2H2

ZNF131 ZNF699 ZNF555 ZBTB48 CHAMP1 ZNF692 ZNF726 ZNF730 ZNF681

1.00e-07693249PF00096
Domainzf-C2H2_6

ZNF699 ZNF555 ZBTB48 ZNF726 ZNF730 ZNF681

2.24e-06314246PF13912
DomainKRAB

ZNF699 ZNF555 ZNF726 ZNF862 ZNF730 ZNF681

4.78e-06358246PS50805
DomainKRAB

ZNF699 ZNF555 ZNF726 ZNF862 ZNF730 ZNF681

4.78e-06358246PF01352
DomainKRAB

ZNF699 ZNF555 ZNF726 ZNF862 ZNF730 ZNF681

5.69e-06369246SM00349
DomainKRAB

ZNF699 ZNF555 ZNF726 ZNF862 ZNF730 ZNF681

5.78e-06370246IPR001909
DomainC2H2_Znf_fam

ZNF131 PLAG1

4.29e-0424242IPR027775
DomainC1_1

UNC13B DGKG

2.42e-0357242PF00130
DomainZF_DAG_PE_2

UNC13B DGKG

3.04e-0364242PS50081
DomainZF_DAG_PE_1

UNC13B DGKG

3.04e-0364242PS00479
DomainC1

UNC13B DGKG

3.13e-0365242SM00109
DomainPE/DAG-bd

UNC13B DGKG

3.23e-0366242IPR002219
DomainBTB

ZNF131 ZBTB48

1.22e-02131242PF00651
DomainBTB

ZNF131 ZBTB48

1.78e-02160242PS50097
DomainBTB

ZNF131 ZBTB48

2.22e-02180242SM00225
DomainBTB/POZ_dom

ZNF131 ZBTB48

2.33e-02185242IPR000210
DomainSKP1/BTB/POZ

ZNF131 ZBTB48

2.43e-02189242IPR011333
Pubmed

Comparative analysis of KRAB zinc finger proteins in rodents and man: evidence for several evolutionarily distinct subfamilies of KRAB zinc finger genes.

ZNF699 ZNF726 ZNF681

2.75e-08925310360839
Pubmed

Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells.

ZNF699 ZNF555 ZNF726 ZNF681

8.24e-0618125437372979
Pubmed

Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.

ZNF750 ZNF131 PLAG1 ZBTB48 ZNF726 ZNF681

1.87e-0580825620412781
Pubmed

Expansion and diversification of KRAB zinc-finger genes within a cluster including Regulator of sex-limitation 1 and 2.

ZNF726 ZNF681

5.18e-051525215885501
Pubmed

Activation of the c-H-ras proto-oncogene by retrovirus insertion and chromosomal rearrangement in a Moloney leukemia virus-induced T-cell leukemia.

ZNF726 ZNF681

9.35e-05202522542606
Pubmed

Emergence of the ZNF91 Krüppel-associated box-containing zinc finger gene family in the last common ancestor of anthropoidea.

ZNF726 ZNF681

9.35e-05202527479878
Pubmed

Regulator of sex-limitation (Rsl) encodes a pair of KRAB zinc-finger genes that control sexually dimorphic liver gene expression.

ZNF726 ZNF681

1.99e-042925214563677
Pubmed

Rapid and efficient cloning of cDNAs encoding Krüppel-like zinc finger proteins by degenerate PCR.

ZNF726 ZNF681

5.71e-04492529630514
Cytoband19p12

ZNF726 ZNF730 ZNF681

1.62e-059025319p12
CytobandEnsembl 112 genes in cytogenetic band chr19p12

ZNF726 ZNF730 ZNF681

4.03e-05122253chr19p12
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ZNF131 PLAG1 ZNF699 ZNF555 ZBTB48 CHAMP1 ZNF692 ZNF726 ZNF862 ZNF730 ZNF681

4.35e-11718201128
GeneFamilyBasic leucine zipper proteins|BTB domain containing

ZNF131 ZBTB48

9.49e-03134202861
CoexpressionZENG_GU_POST_ICB_METAGENE_41

ZNF699 ZNF726 MOB4 ZNF681 BBS10

1.02e-06195255MM17091
ToppCell5'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-pericyte_cell-Pericytes-Pericytes_L.2.3.3.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DGKG ITGA1 CHRM2 ZNF730

2.87e-06179254dc6cd46fa652b296ddbc41855f6377946d0a4cdc
ToppCellTracheal-10x5prime-Epithelial-Epi_airway_neuro-secretory-Neuroendocrine|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

DGKG ZNF555 ZNF730 BBS10

4.20e-06197254fd76cc5e12c7e7943a48f739e4f0626ff7211f51
ToppCellCOVID-19-APC-like-Monocytes|COVID-19 / group, cell type (main and fine annotations)

DGKG RNASE4 ZNF555

9.23e-05158253a0d94bd067424783863a48db20976d4c2043600c
ToppCell367C-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)-|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)

ITGA1 CHRM2 ZNF692

1.13e-04169253225aec04ba762d4c55885257de03a65b63503fbb
ToppCell367C-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)

ITGA1 CHRM2 ZNF692

1.13e-04169253278960f940b646a788360b1c84d641a8d169896b
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_PAX6-Inh_L1-2_PAX6_SCGN|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

LACC1 CHRM2 ZNF726

1.21e-0417325333170a1cc0bc87504d0501fc257a32ff17e02314
ToppCellChildren_(3_yrs)-Mesenchymal-pericyte_cell-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

DGKG ITGA1 CHRM2

1.31e-04178253185b44700f06ec58b3c09c80520502166c965fd6
ToppCellChildren_(3_yrs)-Mesenchymal-pericyte_cell-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

DGKG ITGA1 CHRM2

1.38e-04181253451b87ac95154bb80018b8dd245b4a6389d81411
ToppCell3'-GW_trimst-2-LargeIntestine-Mesenchymal-myocytic-SMC_(PART1/CAPN3+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

DGKG ITGA1 CHRM2

1.38e-04181253beb2771820956be8b190c0088ae3c4efdb53c897
ToppCell5'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast-Myofibroblasts-Myofibroblasts_L.2.3.2.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

RNASE4 ITGA1 CHRM2

1.43e-04183253bc7dd6a40ec9c773d005c1a46f305d40cdd0a326
ToppCellTCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-1|TCGA-Pancreas / Sample_Type by Project: Shred V9

PHF6 ITGA1 CHAMP1

1.50e-0418625303db813598b67b1e08f759758a1c2023396921fa
ToppCellFetal_29-31_weeks-Mesenchymal-pericyte_cell-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

DGKG ITGA1 CHRM2

1.52e-04187253fa01a61bfd13feb033ba1e35cf513707b1bff8c8
ToppCellChildren_(3_yrs)-Mesenchymal-pericyte_cell-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

DGKG ITGA1 CHRM2

1.52e-0418725386250acf088ec0c4800a0dfa031b0d4f7e52c342
ToppCellChildren_(3_yrs)-Mesenchymal-pericyte_cell|Children_(3_yrs) / Lineage, Cell type, age group and donor

DGKG ITGA1 CHRM2

1.54e-04188253ee151792c7ac9afe820f1a281c6dab383799f358
ToppCellControl-Endothelial-VE_Capillary_A|Endothelial / Disease state, Lineage and Cell class

UNC13B ITGA1 CHRM2

1.54e-0418825388b3415e33db81726dd29c1f50c886e057af50a0
ToppCellMesenchymal-pericyte_cell|World / Lineage, Cell type, age group and donor

DGKG ITGA1 CHRM2

1.57e-04189253d7ed96add29f219183c802895fbff519b627f635
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_myocytic-mes_pericyte_(14)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

DGKG ITGA1 CHRM2

1.64e-041922535000440dc1ed17e7474d340921bdff945646f27e
ToppCellControl-Fibroblasts-Vascular_smooth_muscle|Control / group, cell type (main and fine annotations)

DGKG ITGA1 CHRM2

1.67e-0419325360e44aac8be0430ad35e20eb98b1b700d76a0427
ToppCellIPF-Endothelial-VE_Capillary_A|Endothelial / Disease state, Lineage and Cell class

UNC13B ITGA1 CHRM2

1.69e-04194253777ce41c3f22c591e2d81120f189b834e53ffb4b
ToppCell3'-GW_trimst-1-SmallIntestine-Mesenchymal-myocytic|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

DGKG ITGA1 CHRM2

1.72e-0419525326a3a5daf389606ef1ebb35533f12e60853b3a12
ToppCellParenchymal-NucSeq-Stromal-Pericyte|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

DGKG ITGA1 CHRM2

1.77e-0419725341dd312f46a2b983c8d864adeb6970c0ca4a8048
ToppCellParenchymal-NucSeq-Stromal-Pericyte-Muscle_pericyte_pulmonary|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

DGKG ITGA1 CHRM2

1.77e-04197253f66945f9007d59d4208849c7fd727f8519713fbc
ToppCellTracheal-NucSeq-Stromal-Myofibroblastic-Muscle_smooth_airway_ASM|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

DGKG ITGA1 CHRM2

1.80e-0419825322e766df1276c5b14aa0d83f434f47140ebb98ea
ToppCellTracheal-NucSeq-Stromal-Myofibroblastic|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

DGKG ITGA1 CHRM2

1.80e-04198253c12e7511628db819a52959bb68580e27c00c2e41
ToppCellBronchial-NucSeq-Stromal-Pericyte-Muscle_pericyte_pulmonary|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

DGKG ITGA1 CHRM2

1.82e-04199253929f809579368201331d9099d8904b6e3c41797b
ToppCellBronchial-NucSeq-Stromal-Pericyte|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

DGKG ITGA1 CHRM2

1.82e-04199253854628ce91068093c14bd4d45ba38c41469f3549
ToppCellNeuronal-Inhibitory-iA-iA_1(SST_PAX6)-PAX6-TNFAIP8L3-L1-2|Neuronal / cells hierarchy compared to all cells using T-Statistic

LACC1 CHRM2 ZNF726

1.85e-04200253978dfb3c1d5e1c3d778a089175c50b8b719626c0
ToppCellNeuronal-Inhibitory-iA-iA_1(SST_PAX6)-PAX6-TNFAIP8L3|Neuronal / cells hierarchy compared to all cells using T-Statistic

LACC1 CHRM2 ZNF726

1.85e-04200253d28b27776c46054b01bdd1e0f1db7c5cd5a48b88
Diseasegout, hyperuricemia

MALRD1 ZNF730

7.56e-0516242EFO_0004274, EFO_0009104
Diseasesusceptibility to pneumonia measurement

ITGA1 MALRD1

2.82e-0397242EFO_0008410
DiseaseObesity

PHF6 BBS10

1.20e-02205242C0028754

Protein segments in the cluster

PeptideGeneStartEntry
TFKKTFKHLLMCHYK

CHRM2

446

P08172
FKHLLMCHYKNIGAT

CHRM2

451

P08172
NHKFISQLMCDYFFK

BBS10

186

Q8TAM1
VQYHHAAKAKFLCIM

LACC1

31

Q8IV20
CTKHSFYMLDKHDFQ

ITGA1

756

P56199
EFLHFFYKHCMHKFT

PPP4R3C

461

Q6ZMV5
FYKHCMHKFTAPLLA

PPP4R3C

466

Q6ZMV5
SKRSKNCKIIFHYHM

MALRD1

1376

Q5VYJ5
MKHFKKPTYCNFCHI

DGKG

276

P49619
HKLKHFKFKLYQECC

CCDC82

476

Q8N4S0
KMIFYQKSAKLFHCH

CHAMP1

51

Q96JM3
HLKKVYASFALCMFV

TMBIM6

26

P55061
FLCHRFTKFVMKYNL

MOB4

186

Q9Y3A3
KYSKFSHMHLMAFRK

BMT2

306

Q1RMZ1
THKCNYCEKMFHRKD

PLAG1

91

Q6DJT9
KMTLYHCKRFNTFIH

RNASE4

61

P34096
CHKKFLSKYYLKVHN

ZBTB48

296

P10074
EKSHLFNHMKYGLCK

ZNF750

36

Q32MQ0
FNAKKAAAHYKCMLF

PHF6

231

Q8IWS0
GKAFYCHISLQKHMR

ZNF555

486

Q8NEP9
HLCKSADYMNLHFKV

UNC13B

1026

O14795
HSKIFQCDKYVKVFH

ZNF730

141

Q6ZMV8
KYHAKSKAHMFCVNA

ZNF862

191

O60290
SFCMFSHKTQHKSIY

ZNF726

181

A6NNF4
IFQCDKYMKIFHKFS

ZNF681

141

Q96N22
CNRSFKLFYHFKEHM

ZNF131

266

P52739
AFHFLACFKKHMKTP

ZNF699

231

Q32M78
CGKSFNFKKHLKEHM

ZNF692

366

Q9BU19