Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionmetalloexopeptidase activity

ANPEP ERAP1 AGBL5 MEP1A AEBP1 ERAP2 LNPEP

4.88e-07701367GO:0008235
GeneOntologyMolecularFunctionexopeptidase activity

ANPEP ERAP1 AGBL5 MEP1A AEBP1 ERAP2 LNPEP

1.03e-051101367GO:0008238
GeneOntologyMolecularFunctionmetalloaminopeptidase activity

ANPEP ERAP1 ERAP2 LNPEP

2.74e-05261364GO:0070006
GeneOntologyMolecularFunction3',5'-cGMP-inhibited cyclic-nucleotide phosphodiesterase activity

PDE3A PDE3B

4.60e-0521362GO:0004119
GeneOntologyMolecularFunctionalpha-1,3-galactosyltransferase activity

ABO A3GALT2

4.60e-0521362GO:0001962
GeneOntologyMolecularFunctionpeptidase activity

PCSK2 MASP1 RELN ANPEP ERAP1 AGBL5 MEP1A AEBP1 ERAP2 LNPEP PCSK7 CORIN C2 USP48

1.53e-0465413614GO:0008233
GeneOntologyMolecularFunctionprotein kinase B binding

PDE3B ANKRD2 PINK1

1.96e-04171363GO:0043422
GeneOntologyMolecularFunctionaminopeptidase activity

ANPEP ERAP1 ERAP2 LNPEP

2.07e-04431364GO:0004177
GeneOntologyMolecularFunctiontRNA (cytidine-3-)-methyltransferase activity

METTL2A METTL2B

2.74e-0441362GO:0052735
GeneOntologyMolecularFunctionmetallopeptidase activity

ANPEP ERAP1 AGBL5 MEP1A AEBP1 ERAP2 LNPEP

4.47e-042001367GO:0008237
GeneOntologyMolecularFunctionNAD+-protein-cysteine ADP-ribosyltransferase activity

PARP11 PARP6

6.78e-0461362GO:0140803
GeneOntologyMolecularFunctioncyclic-nucleotide phosphodiesterase activity

PDE3A PDE3B ADPRM

8.02e-04271363GO:0004112
GeneOntologyMolecularFunctionzinc ion binding

HDAC4 ANPEP ERAP1 ZSWIM5 AGBL5 RNF217 MEP1A BLM PIKFYVE ZCCHC4 DNLZ AEBP1 ERAP2 LNPEP L3MBTL3

1.11e-0389113615GO:0008270
GeneOntologyMolecularFunctiontransition metal ion binding

ABO HDAC4 ANPEP ERAP1 ZSWIM5 AGBL5 RNF217 MEP1A BLM PIKFYVE ZCCHC4 ADPRM DNLZ AEBP1 ERAP2 LNPEP LOXL3 L3MBTL3

1.19e-03118913618GO:0046914
GeneOntologyMolecularFunctionUDP-galactosyltransferase activity

ABO A3GALT2 B3GNT3

1.33e-03321363GO:0035250
GeneOntologyBiologicalProcesspositive regulation of aorta morphogenesis

EPHB4 NOTCH1 NOTCH4

1.09e-0641353GO:1903849
GeneOntologyBiologicalProcessregulation of aorta morphogenesis

EPHB4 NOTCH1 NOTCH4

5.41e-0661353GO:1903847
GeneOntologyBiologicalProcessnegative regulation of myotube differentiation

HDAC5 HDAC4 ANKRD2 NOTCH1

9.63e-06211354GO:0010832
GeneOntologyBiologicalProcesspeptide catabolic process

ANPEP ERAP1 ERAP2 LNPEP

1.41e-05231354GO:0043171
GeneOntologyBiologicalProcessprotein processing

CPLANE2 PCSK2 MASP1 OGT ANPEP MEP1A AEBP1 PCSK7 CORIN NOTCH4

1.87e-0528513510GO:0016485
GeneOntologyBiologicalProcesspositive regulation of artery morphogenesis

EPHB4 NOTCH1 NOTCH4

2.24e-0591353GO:1905653
GeneOntologyBiologicalProcessprotein maturation

CPLANE2 PCSK2 MASP1 OGT ANPEP MEP1A DNLZ AEBP1 PCSK7 SDF2L1 CORIN MVP HSPA9 NOTCH4

5.62e-0561913514GO:0051604
GeneOntologyBiologicalProcessvenous blood vessel morphogenesis

EPHB4 NOTCH1 NOTCH4

7.47e-05131353GO:0048845
GeneOntologyBiologicalProcesspeptide hormone processing

PCSK2 MEP1A PCSK7 CORIN

1.47e-04411354GO:0016486
GeneOntologyBiologicalProcessaorta morphogenesis

EPHB4 MYLK NOTCH1 NOTCH4

1.47e-04411354GO:0035909
GeneOntologyBiologicalProcessregulation of artery morphogenesis

EPHB4 NOTCH1 NOTCH4

1.74e-04171353GO:1905651
GeneOntologyCellularComponentcentriole

CPLANE2 IFT140 PLA2G3 CEP164 CEP170 CCDC78 CEP135 WDR90

1.72e-051721368GO:0005814
DomainERAP1-like_C_dom

ANPEP ERAP1 ERAP2 LNPEP

1.79e-0781354IPR024571
DomainERAP1_C

ANPEP ERAP1 ERAP2 LNPEP

1.79e-0781354PF11838
DomainPeptidase_M1

ANPEP ERAP1 ERAP2 LNPEP

1.24e-06121354IPR001930
DomainPeptidase_M1_N

ANPEP ERAP1 ERAP2 LNPEP

1.77e-06131354IPR014782
DomainPeptidase_M1

ANPEP ERAP1 ERAP2 LNPEP

1.77e-06131354PF01433
DomainEGF-like_CS

EPHB4 HSPG2 MASP1 RELN LAMA1 MEP1A HMCN2 NOTCH1 NOTCH4 CRB2

2.04e-0526113510IPR013032
DomainEGF_2

EPHB4 HSPG2 MASP1 RELN LAMA1 MEP1A HMCN2 NOTCH1 NOTCH4 CRB2

2.32e-0526513510PS01186
Domain-

AP2A1 AP2A2

5.19e-05213522.60.40.1030
DomainClathrin_a-adaptin_app_Ig-like

AP2A1 AP2A2

5.19e-0521352IPR013038
DomainAP2_complex_asu

AP2A1 AP2A2

5.19e-0521352IPR017104
DomainClathrin_a-adaptin_app_sub_C

AP2A1 AP2A2

5.19e-0521352IPR003164
DomainAlpha_adaptin_C

AP2A1 AP2A2

5.19e-0521352PF02296
DomainEGF-like_dom

HSPG2 MASP1 RELN LAMA1 MEP1A HMCN2 NOTCH1 NOTCH4 CRB2

8.37e-052491359IPR000742
DomainEGF_1

HSPG2 MASP1 RELN LAMA1 MEP1A HMCN2 NOTCH1 NOTCH4 CRB2

1.00e-042551359PS00022
DomainHDAC4_Gln

HDAC5 HDAC4

1.55e-0431352PF12203
DomainHist_deacetylase_Gln_rich_N

HDAC5 HDAC4

1.55e-0431352IPR024643
DomainAnk_2

CTTNBP2 TRPC7 ANKRD2 ANKDD1A MYO16 NOTCH1 NOTCH4 INVS

1.72e-042151358PF12796
DomainAnk

CTTNBP2 TRPC7 ANKRD2 ANKDD1A MYO16 NOTCH1 NOTCH4 INVS

2.56e-042281358PF00023
DomainEGF_CA

HSPG2 MASP1 HMCN2 NOTCH1 NOTCH4 CRB2

2.60e-041221356SM00179
DomainEGF-like_Ca-bd_dom

HSPG2 MASP1 HMCN2 NOTCH1 NOTCH4 CRB2

2.84e-041241356IPR001881
DomainNotch

NOTCH1 NOTCH4

3.08e-0441352IPR008297
DomainNODP

NOTCH1 NOTCH4

3.08e-0441352PF07684
DomainNotch_NODP_dom

NOTCH1 NOTCH4

3.08e-0441352IPR011656
DomainGlyco_transf_6

ABO A3GALT2

3.08e-0441352PF03414
DomainMeTrfase

METTL2A METTL2B

3.08e-0441352IPR026113
DomainClathrin_a/coatomer_app_sub_C

AP2A1 AP2A2

3.08e-0441352IPR015873
DomainGlyco_trans_6

ABO A3GALT2

3.08e-0441352IPR005076
DomainNotch_NOD_dom

NOTCH1 NOTCH4

3.08e-0441352IPR010660
DomainNOD

NOTCH1 NOTCH4

3.08e-0441352PF06816
DomainHistone_deAcase_II_euk

HDAC5 HDAC4

3.08e-0441352IPR017320
Domain-

AP2A1 AP2A2

3.08e-04413523.30.310.30
DomainNOD

NOTCH1 NOTCH4

3.08e-0441352SM01338
DomainNODP

NOTCH1 NOTCH4

3.08e-0441352SM01339
DomainEGF_3

HSPG2 MASP1 RELN MEP1A HMCN2 NOTCH1 NOTCH4 CRB2

3.13e-042351358PS50026
Domain-

CTTNBP2 TRPC7 ANKRD2 ANKDD1A MYO16 NOTCH1 NOTCH4 INVS

4.49e-0424813581.25.40.20
DomainANK

CTTNBP2 TRPC7 ANKRD2 ANKDD1A MYO16 NOTCH1 NOTCH4 INVS

4.86e-042511358SM00248
DomainLNR

NOTCH1 NOTCH4

5.11e-0451352PS50258
DomainANK_REPEAT

CTTNBP2 TRPC7 ANKRD2 ANKDD1A MYO16 NOTCH1 NOTCH4 INVS

5.12e-042531358PS50088
DomainAnkyrin_rpt-contain_dom

CTTNBP2 TRPC7 ANKRD2 ANKDD1A MYO16 NOTCH1 NOTCH4 INVS

5.26e-042541358IPR020683
DomainANK_REP_REGION

CTTNBP2 TRPC7 ANKRD2 ANKDD1A MYO16 NOTCH1 NOTCH4 INVS

5.26e-042541358PS50297
DomainGalactose-bd-like

EPHB4 PCSK2 LAMA1 AEBP1 PCSK7

6.01e-04941355IPR008979
DomainAnkyrin_rpt

CTTNBP2 TRPC7 ANKRD2 ANKDD1A MYO16 NOTCH1 NOTCH4 INVS

6.44e-042621358IPR002110
DomainEGF_Ca-bd_CS

MASP1 HMCN2 NOTCH1 NOTCH4 CRB2

6.93e-04971355IPR018097
DomainZINC_PROTEASE

ANPEP ERAP1 MEP1A ERAP2 LNPEP

7.26e-04981355PS00142
DomainEGF_CA

MASP1 HMCN2 NOTCH1 NOTCH4 CRB2

7.61e-04991355PS01187
DomainMethyltransf_12

METTL2A METTL2B

7.63e-0461352IPR013217
DomainMethyltransf_12

METTL2A METTL2B

7.63e-0461352PF08242
DomainASX_HYDROXYL

MASP1 HMCN2 NOTCH1 NOTCH4 CRB2

7.96e-041001355PS00010
DomainGrowth_fac_rcpt_

EPHB4 HSPG2 LAMA1 HMCN2 NOTCH1 NOTCH4

9.56e-041561356IPR009030
DomainEGF-type_Asp/Asn_hydroxyl_site

MASP1 HMCN2 NOTCH1 NOTCH4 CRB2

1.04e-031061355IPR000152
DomainhEGF

NOTCH1 NOTCH4 CRB2

1.06e-03281353PF12661
DomainNotch_dom

NOTCH1 NOTCH4

1.06e-0371352IPR000800
DomainP_proprotein

PCSK2 PCSK7

1.06e-0371352PF01483
DomainS8_pro-domain

PCSK2 PCSK7

1.06e-0371352IPR032815
DomainPrprotnconvertsP

PCSK2 PCSK7

1.06e-0371352IPR002884
DomainNotch

NOTCH1 NOTCH4

1.06e-0371352PF00066
Domain-

PCSK2 PCSK7

1.06e-03713523.30.70.850
DomainS8_pro-domain

PCSK2 PCSK7

1.06e-0371352PF16470
DomainNL

NOTCH1 NOTCH4

1.06e-0371352SM00004
DomainCoatomer/calthrin_app_sub_C

AP2A1 AP2A2

1.41e-0381352IPR009028
DomainLAMININ_IVA

HSPG2 LAMA1

1.41e-0381352PS51115
DomainLaminin_B

HSPG2 LAMA1

1.41e-0381352PF00052
DomainLamB

HSPG2 LAMA1

1.41e-0381352SM00281
DomainLaminin_IV

HSPG2 LAMA1

1.41e-0381352IPR000034
DomainEGF

HSPG2 RELN LAMA1 MEP1A NOTCH1 NOTCH4 CRB2

1.62e-032351357SM00181
DomainIGc2

HSPG2 MYLK MYOM3 HMCN2 UNC5D CNTFR LILRA4

1.62e-032351357SM00408
DomainIg_sub2

HSPG2 MYLK MYOM3 HMCN2 UNC5D CNTFR LILRA4

1.62e-032351357IPR003598
DomainPeptidase_S8_His-AS

PCSK2 PCSK7

1.81e-0391352IPR022398
DomainPH_dom-spectrin-type

SPTBN4 SPTBN5

1.81e-0391352IPR001605
DomainAlpha_adaptinC2

AP2A1 AP2A2

1.81e-0391352PF02883
DomainPeptidase_S8_Ser-AS

PCSK2 PCSK7

1.81e-0391352IPR023828
DomainClathrin_a/b/g-adaptin_app_Ig

AP2A1 AP2A2

1.81e-0391352IPR008152
DomainAlpha_adaptinC2

AP2A1 AP2A2

1.81e-0391352SM00809
Domain-

EPHB4 PCSK2 AEBP1 PCSK7

1.93e-037313542.60.120.260
DomainEGF

HSPG2 MEP1A NOTCH1 NOTCH4 CRB2

2.22e-031261355PF00008
DomainPeptidase_S8_subtilisin-rel

PCSK2 PCSK7

2.25e-03101352IPR015500
DomainSUBTILASE_ASP

PCSK2 PCSK7

2.25e-03101352PS00136
DomainSUBTILASE_HIS

PCSK2 PCSK7

2.25e-03101352PS00137
DomainSUBTILASE_SER

PCSK2 PCSK7

2.25e-03101352PS00138
DomainLAM_G_DOMAIN

HSPG2 LAMA1 CRB2

2.59e-03381353PS50025
DomainHist_deacetyl

HDAC5 HDAC4

2.73e-03111352PF00850
Domain-

PCSK2 PCSK7

2.73e-031113523.40.50.200
DomainMethyltransf_16

FAM86B2 EEF1AKMT3

2.73e-03111352IPR019410
Domain-

HDAC5 HDAC4

2.73e-031113523.40.800.20
DomainPeptidase_S8/S53_dom

PCSK2 PCSK7

2.73e-03111352IPR000209
DomainHis_deacetylse_dom

HDAC5 HDAC4

2.73e-03111352IPR023801
DomainPeptidase_S8

PCSK2 PCSK7

2.73e-03111352PF00082
DomainLaminin_G_1

HSPG2 LAMA1

2.73e-03111352PF00054
DomainMethyltransf_16

FAM86B2 EEF1AKMT3

2.73e-03111352PF10294
DomainHis_deacetylse

HDAC5 HDAC4

2.73e-03111352IPR000286
DomainLaminin_G_2

HSPG2 LAMA1 CRB2

3.00e-03401353PF02210
DomainCoatomer/clathrin_app_Ig-like

AP2A1 AP2A2

3.26e-03121352IPR013041
DomainEGF_CA

MASP1 HMCN2 NOTCH1 NOTCH4

3.51e-03861354PF07645
DomainSTART

STARD8 CERT1

3.84e-03131352SM00234
DomainLamG

HSPG2 LAMA1 CRB2

3.94e-03441353SM00282
DomainClathrin/coatomer_adapt-like_N

AP2A1 AP2A2

5.12e-03151352IPR002553
DomainSTART_lipid-bd_dom

STARD8 CERT1

5.12e-03151352IPR002913
DomainAdaptin_N

AP2A1 AP2A2

5.12e-03151352PF01602
DomainSTART

STARD8 CERT1

5.12e-03151352PF01852
DomainSTART

STARD8 CERT1

5.12e-03151352PS50848
PathwayREACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY

HDAC5 HDAC4 NOTCH1 NOTCH4

1.90e-05231004MM14954
PathwayREACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY

HDAC5 HDAC4 NOTCH1 NOTCH4

4.28e-05281004M6177
Pubmed

The oxytocinase subfamily of M1 aminopeptidases.

ERAP1 ERAP2 LNPEP

6.11e-083138316054015
Pubmed

Regulation of the human leukocyte-derived arginine aminopeptidase/endoplasmic reticulum-aminopeptidase 2 gene by interferon-gamma.

ERAP1 ERAP2 LNPEP

6.11e-083138315691326
Pubmed

Probing the S1 specificity pocket of the aminopeptidases that generate antigenic peptides.

ERAP1 ERAP2 LNPEP

6.11e-083138321314638
Pubmed

Cell-Specific and Variant-Linked Alterations in Expression of ERAP1, ERAP2, and LNPEP Aminopeptidases in Psoriasis.

ERAP1 ERAP2 LNPEP

6.11e-083138336716917
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

CTTNBP2 STARD8 MAN2B2 ZNF618 RALGAPA2 TUBGCP5 PPP4R4 CEP170 PIKFYVE RHOBTB1 AP2A2 CEP135 SAFB2

9.42e-084931381315368895
Pubmed

A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene.

TCAF2 RELN CTTNBP2 NMNAT1 LINC01599 SPTBN5 ZGPAT MVP CDH5 HSPA9 PINK1

9.66e-083311381119490893
Pubmed

A genome-wide association study identifies a functional ERAP2 haplotype associated with birdshot chorioretinopathy.

ERAP1 ERAP2 LNPEP

2.44e-074138324957906
Pubmed

Biochemical and enzymatic properties of the M1 family of aminopeptidases involved in the regulation of blood pressure.

ANPEP ERAP1 LNPEP

2.44e-074138317999179
Pubmed

The Wnt/beta-catenin pathway modulates vascular remodeling and specification by upregulating Dll4/Notch signaling.

EPHB4 CDH5 NOTCH1 NOTCH4

8.78e-0719138420627076
Pubmed

Sox17 is indispensable for acquisition and maintenance of arterial identity.

EPHB4 CDH5 NOTCH1 NOTCH4

1.09e-0620138424153254
Pubmed

Artery and vein size is balanced by Notch and ephrin B2/EphB4 during angiogenesis.

EPHB4 NOTCH1 NOTCH4

2.11e-067138318952909
Pubmed

Loss of Gata5 in mice leads to bicuspid aortic valve.

EPHB4 CDH5 NOTCH1 NOTCH4

2.37e-0624138421633169
Pubmed

Dosage-dependent requirement for mouse Vezf1 in vascular system development.

EPHB4 CDH5 NOTCH1 NOTCH4

5.22e-0629138415882861
Pubmed

Sequence-specific recognition of a PxLPxI/L motif by an ankyrin repeat tumbler lock.

PDE3B HDAC5 HDAC4

9.85e-0611138322649097
Pubmed

Delta-like ligand-4 regulates Notch-mediated maturation of second heart field progenitor-derived pharyngeal arterial endothelial cells.

EPHB4 NOTCH1 NOTCH4

1.31e-0512138336082581
Pubmed

Altered expression of endoplasmic reticulum aminopeptidases ERAP1 and ERAP2 in transformed non-lymphoid human tissues.

ERAP1 ERAP2

1.56e-052138218393273
Pubmed

Differential patterns of NOTCH1-4 receptor expression are markers of glioma cell differentiation.

NOTCH1 NOTCH4

1.56e-052138224305720
Pubmed

Notch signaling in cancer.

NOTCH1 NOTCH4

1.56e-052138212496471
Pubmed

Disruption of the Class IIa HDAC Corepressor Complex Increases Energy Expenditure and Lipid Oxidation.

HDAC5 HDAC4

1.56e-052138227626651
Pubmed

Antigenic peptide trimming by ER aminopeptidases--insights from structural studies.

ERAP1 ERAP2

1.56e-052138223545452
Pubmed

Structural and stability studies of the human mtHsp70-escort protein 1: an essential mortalin co-chaperone.

DNLZ HSPA9

1.56e-052138223462535
Pubmed

Inhibition of Notch pathway attenuates the progression of human immunodeficiency virus-associated nephropathy.

NOTCH1 NOTCH4

1.56e-052138223389453
Pubmed

Notch signaling: from the outside in.

NOTCH1 NOTCH4

1.56e-052138211112321
Pubmed

Thymosin beta4 induces angiogenesis through Notch signaling in endothelial cells.

NOTCH1 NOTCH4

1.56e-052138223749167
Pubmed

A pathophysiological role of PDE3 in allergic airway inflammation.

PDE3A PDE3B

1.56e-052138229367458
Pubmed

Polymorphisms in endoplasmic reticulum aminopeptidase genes are associated with cervical cancer risk in a Chinese Han population.

ERAP1 ERAP2

1.56e-052138232321463
Pubmed

Functionally distinct ERAP1 and ERAP2 are a hallmark of HLA-A29-(Birdshot) Uveitis.

ERAP1 ERAP2

1.56e-052138230215709
Pubmed

The ER aminopeptidase ERAP1 enhances or limits antigen presentation by trimming epitopes to 8-9 residues.

ERAP1 ERAP2

1.56e-052138212436110
Pubmed

An IFN-gamma-induced aminopeptidase in the ER, ERAP1, trims precursors to MHC class I-presented peptides.

ERAP1 ERAP2

1.56e-052138212436109
Pubmed

ERAP1-ERAP2 haplotypes are associated with ankylosing spondylitis in Polish patients.

ERAP1 ERAP2

1.56e-052138230794838
Pubmed

Notch-1 and notch-4 receptors as prognostic markers in breast cancer.

NOTCH1 NOTCH4

1.56e-052138220444726
Pubmed

Cloning of cDNAs encoding two related 100-kD coated vesicle proteins (alpha-adaptins).

AP2A1 AP2A2

1.56e-05213822564002
Pubmed

Nuclear calcium signaling regulates nuclear export of a subset of class IIa histone deacetylases following synaptic activity.

HDAC5 HDAC4

1.56e-052138223364788
Pubmed

Genetic diversity at endoplasmic reticulum aminopeptidases is maintained by balancing selection and is associated with natural resistance to HIV-1 infection.

ERAP1 ERAP2

1.56e-052138220843824
Pubmed

ERAP1-ERAP2 dimerization increases peptide-trimming efficiency.

ERAP1 ERAP2

1.56e-052138224928998
Pubmed

Role of phosphodiesterase type 3A and 3B in regulating platelet and cardiac function using subtype-selective knockout mice.

PDE3A PDE3B

1.56e-052138217482796
Pubmed

Distinct molecular mechanisms leading to deficient expression of ER-resident aminopeptidases in melanoma.

ERAP1 ERAP2

1.56e-052138220419298
Pubmed

Targeted disruption of PDE3B, but not PDE3A, protects murine heart from ischemia/reperfusion injury.

PDE3A PDE3B

1.56e-052138225877153
Pubmed

Hepatitis B virus X protein activates Notch signaling by its effects on Notch1 and Notch4 in human hepatocellular carcinoma.

NOTCH1 NOTCH4

1.56e-052138226530164
Pubmed

The role of LNPEP and ANPEP gene polymorphisms in the pathogenesis of pre-eclampsia.

ANPEP LNPEP

1.56e-052138232619880
Pubmed

Expression of endoplasmic reticulum aminopeptidases in EBV-B cell lines from healthy donors and in leukemia/lymphoma, carcinoma, and melanoma cell lines.

ERAP1 ERAP2

1.56e-052138216585582
Pubmed

Phosphodiesterase type 3A (PDE3A), but not type 3B (PDE3B), contributes to the adverse cardiac remodeling induced by pressure overload.

PDE3A PDE3B

1.56e-052138231051182
Pubmed

Introduction to Notch signaling.

NOTCH1 NOTCH4

1.56e-052138225053477
Pubmed

Class IIa histone deacetylases link cAMP signaling to the myelin transcriptional program of Schwann cells.

HDAC5 HDAC4

1.56e-052138229472387
Pubmed

Association of an ERAP1 ERAP2 haplotype with familial ankylosing spondylitis.

ERAP1 ERAP2

1.56e-052138219433412
Pubmed

The crystal structure of human endoplasmic reticulum aminopeptidase 2 reveals the atomic basis for distinct roles in antigen processing.

ERAP1 ERAP2

1.56e-052138222106953
Pubmed

Concerted peptide trimming by human ERAP1 and ERAP2 aminopeptidase complexes in the endoplasmic reticulum.

ERAP1 ERAP2

1.56e-052138215908954
Pubmed

Pde3a and Pde3b regulation of murine pulmonary artery smooth muscle cell growth and metabolism.

PDE3A PDE3B

1.56e-052138239435735
Pubmed

Placental leucine aminopeptidase efficiently generates mature antigenic peptides in vitro but in patterns distinct from endoplasmic reticulum aminopeptidase 1.

ERAP1 LNPEP

1.56e-052138220592285
Pubmed

Synergy of endoplasmic reticulum aminopeptidase 1 and 2 (ERAP1 and ERAP2) polymorphisms in atopic dermatitis: Effects on disease prevalence.

ERAP1 ERAP2

1.56e-052138233309189
Pubmed

Genetic Variants in ERAP1 and ERAP2 Associated With Immune-Mediated Diseases Influence Protein Expression and the Isoform Profile.

ERAP1 ERAP2

1.56e-052138229108111
Pubmed

The association of ERAP1 and ERAP2 single nucleotide polymorphisms and their haplotypes with psoriasis vulgaris is dependent on the presence or absence of the HLA-C*06:02 allele and age at disease onset.

ERAP1 ERAP2

1.56e-052138229183862
Pubmed

An allelic variant in the intergenic region between ERAP1 and ERAP2 correlates with an inverse expression of the two genes.

ERAP1 ERAP2

1.56e-052138229991817
Pubmed

Separate effects of the ankylosing spondylitis associated ERAP1 and ERAP2 aminopeptidases determine the influence of their combined phenotype on the HLA-B*27 peptidome.

ERAP1 ERAP2

1.56e-052138228063628
Pubmed

Clinicopathological significance of aberrant Notch receptors in intrahepatic cholangiocarcinoma.

NOTCH1 NOTCH4

1.56e-052138225031748
Pubmed

A conserved histidine in human DNLZ/HEP is required for stimulation of HSPA9 ATPase activity.

DNLZ HSPA9

1.56e-052138221530495
Pubmed

The ERAP gene is associated with HCV chronic infection in a Chinese Han population.

ERAP1 ERAP2

1.56e-052138229037997
Pubmed

Critical role of endothelial Notch1 signaling in postnatal angiogenesis.

NOTCH1 NOTCH4

1.56e-052138217158336
Pubmed

Notch-1 and Notch-4 biomarker expression in triple-negative breast cancer.

NOTCH1 NOTCH4

1.56e-052138222084425
Pubmed

Nitric oxide modulates chromatin folding in human endothelial cells via protein phosphatase 2A activation and class II histone deacetylases nuclear shuttling.

HDAC5 HDAC4

1.56e-052138217975112
Pubmed

Genomic organization of the human adipocyte-derived leucine aminopeptidase gene and its relationship to the placental leucine aminopeptidase/oxytocinase gene.

ERAP1 ERAP2

1.56e-052138211481040
Pubmed

Phosphodiesterase 3A (PDE3A) deletion suppresses proliferation of cultured murine vascular smooth muscle cells (VSMCs) via inhibition of mitogen-activated protein kinase (MAPK) signaling and alterations in critical cell cycle regulatory proteins.

PDE3A PDE3B

1.56e-052138221632535
Pubmed

The ER Aminopeptidases, ERAP1 and ERAP2, synergize to self-modulate their respective activities.

ERAP1 ERAP2

1.56e-052138236569828
Pubmed

Class IIa HDACs regulate learning and memory through dynamic experience-dependent repression of transcription.

HDAC5 HDAC4

1.56e-052138231375688
Pubmed

Class II histone deacetylases downregulate GLUT4 transcription in response to increased cAMP signaling in cultured adipocytes and fasting mice.

HDAC5 HDAC4

1.56e-052138222403301
Pubmed

Notch1 and Notch4 are markers for poor prognosis of hepatocellular carcinoma.

NOTCH1 NOTCH4

1.56e-052138223742774
Pubmed

Proximity interactome of lymphatic VE-cadherin reveals mechanisms of junctional remodeling and reelin secretion.

RELN CDH5

1.56e-052138239232006
Pubmed

The DNLZ/HEP zinc-binding subdomain is critical for regulation of the mitochondrial chaperone HSPA9.

DNLZ HSPA9

1.56e-052138222162012
Pubmed

ERAP1-ERAP2 dimers trim MHC I-bound precursor peptides; implications for understanding peptide editing.

ERAP1 ERAP2

1.56e-052138227514473
Pubmed

A Comparative Review of Pregnancy and Cancer and Their Association with Endoplasmic Reticulum Aminopeptidase 1 and 2.

ERAP1 ERAP2

1.56e-052138236834865
Pubmed

The Differential Expression of ERAP1/ERAP2 and Immune Cell Activation in Pre-eclampsia.

ERAP1 ERAP2

1.56e-052138232210971
Pubmed

Serum cytokine receptors in ankylosing spondylitis: relationship to inflammatory markers and endoplasmic reticulum aminopeptidase polymorphisms.

ERAP1 ERAP2

1.56e-052138220595269
Pubmed

Control of cardiac growth by histone acetylation/deacetylation.

HDAC5 HDAC4

1.56e-052138216397154
Pubmed

Cloning, physical mapping and structural characterization of the human alpha(A)-adaptin gene.

AP2A1 AP2A2

1.56e-052138212036598
Pubmed

Major vault protein is a direct target of Notch1 signaling and contributes to chemoresistance in triple-negative breast cancer cells.

MVP NOTCH1

1.56e-052138230336197
Pubmed

Notch1 Regulates Hippocampal Plasticity Through Interaction with the Reelin Pathway, Glutamatergic Transmission and CREB Signaling.

RELN NOTCH1

1.56e-052138226635527
Pubmed

ERAAP synergizes with MHC class I molecules to make the final cut in the antigenic peptide precursors in the endoplasmic reticulum.

ERAP1 ERAP2

1.56e-052138217088086
Pubmed

Comparative expression profiling for human endoplasmic reticulum-resident aminopeptidases 1 and 2 in normal kidney versus distinct renal cell carcinoma subtypes.

ERAP1 ERAP2

1.56e-052138223696916
Pubmed

Notch1 signaling pathway promotes growth and metastasis of gastric cancer via modulating CDH5.

CDH5 NOTCH1

1.56e-052138239172098
Pubmed

Genetic association of ERAP1 and ERAP2 with eclampsia and preeclampsia in northeastern Brazilian women.

ERAP1 ERAP2

1.56e-052138233762660
Pubmed

Atg9A trafficking through the recycling endosomes is required for autophagosome formation.

AP2A1 ATG9A

1.56e-052138227587839
Pubmed

Tmem100, an ALK1 receptor signaling-dependent gene essential for arterial endothelium differentiation and vascular morphogenesis.

EPHB4 CDH5 NOTCH1 NOTCH4

1.58e-0538138422783020
Pubmed

Endothelial TIE1 Restricts Angiogenic Sprouting to Coordinate Vein Assembly in Synergy With Its Homologue TIE2.

EPHB4 CDH5 NOTCH1

1.70e-0513138337317851
Pubmed

Impaired embryonic haematopoiesis yet normal arterial development in the absence of the Notch ligand Jagged1.

CDH5 NOTCH1 NOTCH4

2.15e-0514138318528438
Pubmed

CEP44 ensures the formation of bona fide centriole wall, a requirement for the centriole-to-centrosome conversion.

AGBL5 CEP164 CEP135

2.15e-0514138332060285
Pubmed

Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals.

PCSK2 ZNF618 PLA2G3 RGS12 SPTBN4 SPTBN5

2.30e-05142138619851296
Pubmed

Association of genetic variants with hemorrhagic stroke in Japanese individuals.

PCSK2 ZNF618 PLA2G3 RGS12 SPTBN4 SPTBN5

2.39e-05143138620198315
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

EPHB4 HSPG2 MYOM3 CLASP2 ICE1 RALGAPA2 PLEKHG5 ABCA7 PIKFYVE ZGPAT AP2A1 WDR90 ATG9A SNAPC4 NOTCH1

3.52e-0511051381535748872
Pubmed

Uncontrolled angiogenic precursor expansion causes coronary artery anomalies in mice lacking Pofut1.

EPHB4 CDH5 NOTCH1 NOTCH4

4.03e-0548138428924218
Pubmed

Genetic associations and functional characterization of M1 aminopeptidases and immune-mediated diseases.

ERAP1 ERAP2

4.68e-053138225142031
Pubmed

ERAP1/ERAP2 and RUNX3 polymorphisms are not associated with ankylosing spondylitis susceptibility in Chinese Han.

ERAP1 ERAP2

4.68e-053138229480940
Pubmed

Clathrin-independent endocytic retrieval of SV proteins mediated by the clathrin adaptor AP-2 at mammalian central synapses.

AP2A1 AP2A2

4.68e-053138235014951
Pubmed

A diacidic motif in human immunodeficiency virus type 1 Nef is a novel determinant of binding to AP-2.

AP2A1 AP2A2

4.68e-053138218032517
Pubmed

Notch receptor expression in human brain arteriovenous malformations.

NOTCH1 NOTCH4

4.68e-053138225846406
Pubmed

ERAP1 and ERAP2 Haplotypes Influence Suboptimal HLA-B*27:05-Restricted Anti-Viral CD8+ T Cell Responses Cross-Reactive to Self-Epitopes.

ERAP1 ERAP2

4.68e-053138237686141
Pubmed

Molecular cloning and chromosomal assignment of the human homologue of the rat cGMP-inhibited phosphodiesterase 1 (PDE3A)--a gene involved in fat metabolism located at 11p 15.1.

PDE3A PDE3B

4.68e-05313828921398
Pubmed

Differential expression of Notch genes in human osteoblastic cells.

NOTCH1 NOTCH4

4.68e-053138211836628
Pubmed

Identification of a signal-responsive nuclear export sequence in class II histone deacetylases.

HDAC5 HDAC4

4.68e-053138211509672
Pubmed

Reelin and Notch1 cooperate in the development of the dentate gyrus.

RELN NOTCH1

4.68e-053138219571148
Pubmed

Heterologously overexpressed, affinity-purified human meprin alpha is functionally active and cleaves components of the basement membrane in vitro.

LAMA1 MEP1A

4.68e-053138210620696
GeneFamilyAminopeptidases|CD molecules

ANPEP ERAP1 ERAP2 LNPEP

1.68e-0617964104
GeneFamilyGlycosyltransferase family 6|Blood group antigens

ABO A3GALT2

1.66e-044962429
GeneFamilyHistone deacetylases, class IIA

HDAC5 HDAC4

1.66e-044962992
GeneFamilyAnkyrin repeat domain containing

CTTNBP2 ANKRD2 ANKDD1A MYO16 NOTCH1 NOTCH4 INVS

3.06e-04242967403
GeneFamilyEF-hand domain containing|Spectrins

SPTBN4 SPTBN5

5.76e-0479621113
GeneFamilyMethyltransferase like

EEF1AKMT3 METTL2A METTL2B

7.05e-0433963963
GeneFamilyProprotein convertase subtilisin/kexin family

PCSK2 PCSK7

9.80e-049962973
GeneFamilyBlood group antigens|CD molecules|I-set domain containing|Immunoglobulin like domain containing

HSPG2 MYLK MYOM3 HMCN2 UNC5D

1.68e-03161965593
GeneFamilyStAR related lipid transfer domain containing

STARD8 CERT1

2.80e-0315962759
GeneFamilyCholinergic receptors nicotinic subunits

CHRNB1 CHRNG

3.19e-0316962173
GeneFamilyZinc fingers|Zinc fingers PARP-type|Poly(ADP-ribose) polymerases

PARP11 PARP6

3.60e-0317962684
GeneFamilyIntraflagellar transport proteins|Tetratricopeptide repeat domain containing

IFT140 TRAF3IP1

7.14e-0324962615
GeneFamilyPhosphodiesterases

PDE3A PDE3B

7.14e-0324962681
ToppCellControl-Neu_1|World / 5 Neutrophil clusters in COVID-19 patients

FAM86B2 ICE1 ALDH1L2 ADGRF1 CFAP69 MYO16 LILRA4

2.54e-071381387b7920c9a28d28220e7e4b30cd91ba13d0548eb76
ToppCellwk_20-22-Endothelial-Blood_vessel_endothelial-OMD+_endo|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

PCSK2 HSPG2 PDE3A GARIN1A GIPC2 MYOM3 HMCN2

1.31e-06176138752af8f717dbd3b59eeb868b8b7b256a8f3e57d7a
ToppCellwk_15-18-Endothelial-Blood_vessel_endothelial-OMD+_endo|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

HSPG2 PDE3A GIPC2 MYOM3 HMCN2 ERAP2 CDH5

1.47e-0617913878c9ed247e1c4d655b81ce2f24a9936a7cade718a
ToppCellLPS-IL1RA+antiTNF-Endothelial-Endothelial-Artery|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

HSPG2 PDE3A PDE3B CTTNBP2 GIPC2 CDH5 NOTCH4

2.10e-061891387c45734970036e6d28d5e3fe7c9458fae38a3f624
ToppCelldroplet-Lung-30m-Endothelial-lymphatic_endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

RELN CTTNBP2 MYLK ZNF618 CHRNB1 AEBP1 ANKRD2

2.26e-06191138751cff0594ac7ad8c065c8ea2301f8c149bd062b4
ToppCelldroplet-Lung-30m-Endothelial-lymphatic_endothelial-lymphatic_endothelial_cell|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

RELN CTTNBP2 MYLK ZNF618 CHRNB1 AEBP1 ANKRD2

2.26e-061911387a55b6f0a7ec1a8852ffca593cfdccd7edea09b7b
ToppCelldroplet-Lung-30m-Endothelial-lymphatic_endothelial|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

RELN CTTNBP2 MYLK ZNF618 CHRNB1 AEBP1 ANKRD2

2.26e-06191138738681a1b182d6af5cce85db5431b6eba4b20ad96
ToppCellSmart-start-Cell-Wel_seq-Neoplastic-Stem-like-NPC-like-NPC-like_neural-F|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

NMNAT1 CLASP2 PARP6 ZNF17 IPO13 ZSCAN16 MYO16

2.42e-061931387088c8b1e968f5356502347eaabdc6b1b1d4befd0
ToppCellfacs-Liver-Liver_non-hepato/SCs_st-18m-Endothelial-endothelial_cell_of_hepatic_sinusoid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EPHB4 HSPG2 STARD8 B3GNT3 CDH5 NOTCH1 CNTFR

2.59e-06195138712ba6d95e42d06b1991b011043c0e3370a7b4131
ToppCellfacs-Lung-nan-3m-Endothelial|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EPHB4 RELN PDE3A STARD8 CDH5 NOTCH1 NOTCH4

2.59e-0619513877f9b7f15006610ad591063d90e90367bd6083c7f
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

GALNT15 EPHB4 HSPG2 RELN RALGAPA2 CDH5 NOTCH4

2.68e-0619613878f2031b1a9232c389517fbf3c29f47f9468b0077
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Endothelial|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

GALNT15 EPHB4 HSPG2 RELN RALGAPA2 CDH5 NOTCH4

2.68e-06196138748b4a9cea97a55190217deaf51bf867608c5a9a7
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

GALNT15 EPHB4 HSPG2 RELN RALGAPA2 CDH5 NOTCH4

2.68e-061961387473980c827443464d08a0be28c53e3536369b12a
ToppCellPBMC-Control-Myeloid-Neutrophil-Neutrophil-Neu_1|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

FAM86B2 ANPEP ALDH1L2 ADGRF1 CFAP69 MYO16

5.42e-061421386191a13bba143ecdfc2bfd797c3ac191481388298
ToppCellPBMC-Control-Myeloid-Neutrophil-Neutrophil-Neu_1|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

FAM86B2 ANPEP ALDH1L2 ADGRF1 CFAP69 MYO16

5.65e-061431386b405dba9a83a99cc7b53ce71772bc52a0bbb0d4e
ToppCellInfluenza_Severe-CD4+_T_naive|Influenza_Severe / Disease group and Cell class

HSPG2 PDE3B ZSCAN31 PLEKHG5 AEBP1 MYO16

9.64e-061571386287bdc4e455cd0160261a93d13538e0def49fcd4
ToppCellEntopeduncular-Endothelial-ENDOTHELIAL_STALK|Entopeduncular / BrainAtlas - Mouse McCarroll V32

GALNT15 EPHB4 B3GNT3 CHRNB1 RHOBTB1 CDH5

1.07e-05160138604714d0b9bad4c11fa193ed168e2d84a4df39e2e
ToppCelldroplet-Mammary_Gland-nan-21m-Epithelial-nan|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PARP11 CTTNBP2 OGT BLM AP2A1 EIF2B4

1.28e-0516513867c771f22b58989572c939ed127e637ec28dc0dca
ToppCell343B-Lymphocytic-ILC|343B / Donor, Lineage, Cell class and subclass (all cells)

PARP11 PDE3B CLASP2 ZSCAN16 L3MBTL3 IL9R

1.32e-051661386a54377c703efff42d2cc1a8fdb610facc58053dd
ToppCellmetastatic_Lymph_Node-Myeloid_cells-Microglia/Mac|metastatic_Lymph_Node / Location, Cell class and cell subclass

OGT CERT1 ABCA7 PARP6 RHOBTB1 ATG9A

1.62e-051721386f673a2e697b46e7cfa4186cb3fb2b98e3c83703e
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell_prolif|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

EPHB4 TCAF2 RELN BLM CDH5 NOTCH4

1.62e-051721386c056d44e2e130ceccadfcdceb192a7f095d779c8
ToppCelldroplet-Lung-LUNG-1m-Myeloid-Basophil|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IFT140 CTTNBP2 BLM CORIN SYTL1 IL9R

1.67e-05173138653e97835d7a518c278e7b90a0734eb0095d6aa33
ToppCelldroplet-Lung-1m-Hematologic-myeloid-Basophil/Mast_cell|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

IFT140 CTTNBP2 CHRNB1 BLM CORIN SYTL1

1.67e-051731386117163c5cd2b7aaa1c0682c8ac44b4249df4d2f8
ToppCelldroplet-Lung-LUNG-1m-Myeloid-basophil|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IFT140 CTTNBP2 BLM CORIN SYTL1 IL9R

1.67e-051731386889a880de5fc19d26b82cfef3067869a28ef17ca
ToppCelldroplet-Lung-1m-Hematologic-myeloid-Basophil/Mast_cell-basophil_l26|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

IFT140 CTTNBP2 CHRNB1 BLM CORIN SYTL1

1.67e-05173138601df9baeedf30e3a4891738554cdd300394dbb96
ToppCellprimary_visual_cortex-Non-neuronal-leptomeningeal_cell|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

HSPG2 ANPEP LAMA1 AEBP1 C2 CDH5

1.73e-0517413862891ab2fd05eb4bbd239d1a2865f21ef7f2df39e
ToppCellprimary_visual_cortex-Non-neuronal-leptomeningeal_cell-VLMC|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

HSPG2 ANPEP LAMA1 AEBP1 C2 CDH5

1.73e-051741386eade55f86ef1f7a5355ad65cec3aa6bfc5d3c62d
ToppCelltumor_Lymph_Node_/_Brain-Fibroblasts-Smooth_muscle_cells|tumor_Lymph_Node_/_Brain / Location, Cell class and cell subclass

MASP1 PDE3A MYLK AEBP1 CORIN CNTFR

1.79e-051751386fed9e4120c758fdcc23bb248d1801002b0e0d485
ToppCell3'-Parenchyma_lung-Endothelial-Blood_vessel_EC-pulmonary_artery_endothelial_cell-EC_arterial-EC_arterial_L.2.4.1.3|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

GIPC2 MYLK TUBGCP5 CDH5 NOTCH4 INVS

1.90e-05177138616197068260fc062bf8b730a51a199887ea580b9
ToppCellprimary_visual_cortex-Non-neuronal-leptomeningeal_cell-VLMC-VLMC_Osr1_Mc5r|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

HSPG2 ANPEP LAMA1 AEBP1 C2 CDH5

1.90e-051771386599cf7f5b774e197a1b43c98e4b9a8c1a618f38a
ToppCellcritical-Myeloid-Mast_cell|Myeloid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

HSPG2 PDE3A CTTNBP2 ZNF618 AEBP1 IL9R

2.16e-051811386f0d81ae74d3f32979624a94b2ef93774831a7970
ToppCellCOVID-19-Endothelial_cells-Arterial_endothelial_cells|COVID-19 / group, cell type (main and fine annotations)

HSPG2 GIPC2 RALGAPA2 HMCN2 CDH5 NOTCH4

2.37e-0518413860f19494789f38ab1a420545e15e748ca7eb345c3
ToppCellmetastatic_Brain-Endothelial_cells-Stalk-like_ECs|metastatic_Brain / Location, Cell class and cell subclass

GALNT15 PCSK2 HSPG2 CHST10 CDH5 NOTCH4

2.44e-051851386ad52970e88e8947ef256095bd4b40229b912d58a
ToppCellAdult-Mesenchymal-matrix_fibroblast_2_cell-D231|Adult / Lineage, Cell type, age group and donor

GALNT15 MASP1 PDE3A CTTNBP2 HMCN2 AEBP1

2.44e-051851386fb6bd7e849ecf4ed9cd9c4e2a946a2d12d62f804
ToppCell343B-Lymphocytic-ILC-ILC-1|343B / Donor, Lineage, Cell class and subclass (all cells)

PARP11 PDE3B CLASP2 ZSCAN16 L3MBTL3 IL9R

2.67e-0518813868f6b45ad82bde65e044d17f0edbc3db90d457915
ToppCellfacs-Pancreas-Endocrine-24m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCSK2 RELN CTTNBP2 SPTBN4 RHOBTB1 GOLGB1

2.67e-051881386a91443aa8fa8fa87f7501c59219daa0305bd0bbf
ToppCellHippocampus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Tac1-Inhibitory_Gad1Gad2_Id2.Tac1_(Interneuron,_Neurogliaform1)-|Hippocampus / BrainAtlas - Mouse McCarroll V32

CPLANE2 GIPC2 CCDC85C PZP

2.75e-05561384c1bdee477c871c03d60feed26b24d9f3d4171cb6
ToppCellHippocampus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Tac1-Inhibitory_Gad1Gad2_Id2.Tac1_(Interneuron,_Neurogliaform1)|Hippocampus / BrainAtlas - Mouse McCarroll V32

CPLANE2 GIPC2 CCDC85C PZP

2.75e-05561384c78cbec68922b382595758e100dda9d284836c25
ToppCellPND07-28-samps-Endothelial|PND07-28-samps / Age Group, Lineage, Cell class and subclass

EPHB4 PDE3A RGS12 CDH5 NOTCH1 NOTCH4

2.75e-051891386eb2f8c8a90e5e9f6697a2d13274c94f40e1973e4
ToppCellPND07-28-samps-Endothelial-Postnatal_endothelial|PND07-28-samps / Age Group, Lineage, Cell class and subclass

EPHB4 PDE3A RGS12 CDH5 NOTCH1 NOTCH4

2.75e-051891386d4a25d59d88325d3b20f4287e9b1160c82961a96
ToppCellnucseq-Endothelial-Endothelial_Vascular-Endothelial_large_blood_vessel-AEC|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

HSPG2 PDE3A GIPC2 RALGAPA2 CDH5 NOTCH4

2.92e-05191138650601ef0a5a8f2c2120922989e08e85bf2d9b4ab
ToppCellLPS-antiTNF-Endothelial-Endothelial-Artery|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

HSPG2 PDE3A PDE3B CTTNBP2 GIPC2 NOTCH4

2.92e-0519113864b3d5157344dbfbf4fab518611cd9fa37fac7bd9
ToppCellfacs-Lung-nan-3m-Mesenchymal-Adventitial_Fibroblast|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GALNT15 HSPG2 AEBP1 C2 LOXL3 CNTFR

3.01e-051921386a2c31390da4962bda9a936470b0b68fa1f5d47d1
ToppCellfacs-Lung-nan-3m-Mesenchymal-adventitial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GALNT15 HSPG2 AEBP1 C2 LOXL3 CNTFR

3.01e-051921386eeab1cef7c36ae824381952c5b2c982368c379fd
ToppCellfacs-Liver-Non-hepatocytes-24m-Endothelial-endothelial_cell_of_hepatic_sinusoid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EPHB4 HSPG2 STARD8 RALGAPA2 CDH5 NOTCH1

3.01e-0519213862bfac6b3956265205ca47d06888851ed68b65999
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

GALNT15 HSPG2 RALGAPA2 HMCN2 CDH5 NOTCH4

3.01e-0519213863259cb89d6bcf0a3c6ff1f64d85e8a1f54124e91
ToppCell343B-Lymphocytic-ILC-ILC-1|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

PARP11 PDE3B CLASP2 ZSCAN16 L3MBTL3 IL9R

3.01e-051921386445985fe1bcd33e4f0a1704b27988fbfc9334538
ToppCellfacs-Liver-Non-hepatocytes-24m-Endothelial|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EPHB4 HSPG2 STARD8 RALGAPA2 CDH5 NOTCH1

3.01e-051921386d525f7f088a53110912600a7c9f6d33b9270d534
ToppCell3'-Distal_airway-Endothelial-Blood_vessel_EC-vein_endothelial_cell-EC_venous_pulmonary-EC_venous_pulmonary_L.2.2.1.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TCAF2 HSPG2 STARD8 RALGAPA2 CDH5 NOTCH4

3.10e-051931386c0f0052c24b7fe9e21d2bc6c38047a8e755f87b6
ToppCell3'-Distal_airway-Endothelial-Blood_vessel_EC-vein_endothelial_cell-EC_venous_pulmonary|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TCAF2 HSPG2 STARD8 RALGAPA2 CDH5 NOTCH4

3.10e-051931386682ce63b73a7d02eef240673db67058d7507f744
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

GALNT15 EPHB4 TCAF2 RELN CDH5 NOTCH4

3.19e-051941386cf9cf115dbbb9997f7c303ae07f42f3d80ff9a21
ToppCellfacs-Liver-Non-hepatocytes-24m-Endothelial-endothelial_cell_of_hepatic_sinusoid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EPHB4 HSPG2 STARD8 RALGAPA2 CDH5 NOTCH1

3.19e-051941386c8b9551b93a5aed62154b487db90130604a6125c
ToppCellfacs-Lung-nan-3m-Endothelial-endothelial_cell_of_lung|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EPHB4 PDE3A STARD8 CDH5 NOTCH1 NOTCH4

3.19e-051941386f159ef8541d75a4e98468947f231bb463bec922c
ToppCell3'-Distal_airway-Endothelial-Blood_vessel_EC-vein_endothelial_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TCAF2 HSPG2 STARD8 RALGAPA2 CDH5 NOTCH4

3.28e-05195138653b83e16b350100b1d5791a9c42bd98e37cbc0af
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

GALNT15 HSPG2 RALGAPA2 HMCN2 CDH5 NOTCH4

3.28e-051951386d35102f95bb1e419d2df05ff0a01b6c5c923acef
ToppCell3'-Airway_Nasal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Multiciliated_(nasal)-Multiciliated_(nasal)_L.0.3.1.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DCDC1 TRAF3IP1 BCO2 CCDC78 WDR90 CFAP69

3.28e-05195138679dc031258579ea328181dda33710dd897f1064a
ToppCellkidney_cells-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

GALNT15 HSPG2 HMCN2 CDH5 NOTCH1 NOTCH4

3.38e-051961386a20a56d8997d6db2a10046c8801c619a379de83c
ToppCellfacs-Liver-Non-hepatocytes-3m-Endothelial-endothelial_cell_of_hepatic_sinusoid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EPHB4 HSPG2 STARD8 RALGAPA2 CDH5 NOTCH1

3.47e-051971386deefb492b5f0e6014144bd465c4a6ae4206e8739
ToppCell368C-Endothelial_cells-Endothelial-A_(Artery)|368C / Donor, Lineage, Cell class and subclass (all cells)

EPHB4 HSPG2 GIPC2 RALGAPA2 CDH5 NOTCH4

3.47e-0519713867caa2c86dc4d50b57a7db8f7278d1588282ad6db
ToppCellfacs-Liver-Non-hepatocytes-3m-Endothelial|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EPHB4 HSPG2 STARD8 RALGAPA2 CDH5 NOTCH1

3.47e-051971386a6aaa6faea348291023f0bc4b0f83fbc67d91da6
ToppCell368C-Endothelial_cells-Endothelial-A_(Artery)-|368C / Donor, Lineage, Cell class and subclass (all cells)

EPHB4 HSPG2 GIPC2 RALGAPA2 CDH5 NOTCH4

3.47e-051971386951f18f326967206adbbfc422cce9eea3d2e0854
ToppCell3'-Child09-12-SmallIntestine-Endothelial|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

EPHB4 HSPG2 RELN STARD8 CDH5 NOTCH4

3.47e-05197138686a02fd7b4762b3278e5e60b5483b5fc1206e597
ToppCell356C-Endothelial_cells|356C / Donor, Lineage, Cell class and subclass (all cells)

HSPG2 GIPC2 MYLK RALGAPA2 CDH5 NOTCH4

3.47e-051971386f20eda534b2b28986790b28ce150ca3ba067593a
ToppCell368C-Endothelial_cells|368C / Donor, Lineage, Cell class and subclass (all cells)

EPHB4 HSPG2 GIPC2 RALGAPA2 CDH5 NOTCH4

3.57e-0519813869a2c2201baee51581733e183065298a97eba4553
ToppCellfacs-Liver-Non-hepatocytes-3m-Endothelial-endothelial_cell_of_hepatic_sinusoid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EPHB4 HSPG2 STARD8 RALGAPA2 CDH5 NOTCH1

3.57e-051981386f0f1816a0ed3ae8207442602f5cbe4de0382e4b3
ToppCellParenchymal-NucSeq-Endothelial-Endothelia_vascular-VE_alveolar_capillary_Car4_aerocyte|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

TCAF2 IFT140 PDE3B STARD8 CDH5 NOTCH4

3.67e-051991386dc88ce36cc066eb6c28cfd5b9b60fe07f8cc7b53
ToppCell367C-Endothelial_cells-Endothelial-A_(Artery)|367C / Donor, Lineage, Cell class and subclass (all cells)

GALNT15 HSPG2 GIPC2 RALGAPA2 CDH5 NOTCH4

3.67e-05199138629ed081bd5204a32068b420f2244f3704891547b
ToppCell367C-Endothelial_cells-Endothelial-A_(Artery)-|367C / Donor, Lineage, Cell class and subclass (all cells)

GALNT15 HSPG2 GIPC2 RALGAPA2 CDH5 NOTCH4

3.67e-051991386c2d85f80037f209a4a329790f475d9f98f590262
ToppCellLPS_IL1RA-Endothelial-Endothelial-Gen_Cap|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

EPHB4 RALGAPA2 PLEKHG5 CDH5 NOTCH1 NOTCH4

3.78e-052001386dccec522ab0d7fff62ad6273b02aa9022dbbb8eb
ToppCellInfluenza-Influenza_Severe-Lymphocyte-T/NK-CD4+_T_naive|Influenza_Severe / Disease, condition lineage and cell class

HSPG2 PDE3B ZSCAN31 PLEKHG5 AEBP1 MYO16

3.78e-0520013860382f8fc27d18003761725e714beb6b3f3150057
ToppCellLPS-antiTNF-Epithelial_alveolar-Mes-Like-Differentiating_AT1|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

IFT140 MASP1 CHRNB1 PPP4R4 HMCN2

4.93e-0512813852cf0384240a4a663869cf6b27d954236f6214a9a
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c07-AHNAK|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)

ZSCAN31 PPP4R4 PZP MYO16 ASPDH

9.51e-0514713855e6dd2ddc67b3722f6528e7277cbc7f296098687
ToppCellPericytes-IPF_04|World / lung cells shred on cell class, cell subclass, sample id

ZNF845 PDE3A GARIN1A MYLK AEBP1

1.05e-041501385dbc202bd6db4fb5c8b2abd1200e074a2a9e63a59
ToppCellsaliva-Mild-Moderate_progression_d12-25-Myeloid-Granulocytic-Neutrophil-Neu_c6-FGF23|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

PCSK2 MASP1 STARD8 ICE1 SPTBN4

1.11e-0415213850652ee3443e6fbb679d2c4f326239ae7c803f924
ToppCellHippocampus-Macroglia-POLYDENDROCYTE-P5-P5_2-Sox4-POLYDENDROCYTE_(Neurogenesis.Sox4.Efhd2)|Hippocampus / BrainAtlas - Mouse McCarroll V32

CPLANE2 GARIN1A MYOM3 CCDC85C

1.23e-0482138493b75f8822ffe8870195cd1fe0a7286478f61e79
ToppCellThalamus-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Slc17a7-Tac2-Excitatory_Neuron.Slc17a7.Tac2.Chat_(Habenular_cholinergic_cells)|Thalamus / BrainAtlas - Mouse McCarroll V32

CCDC85C PKDREJ ANKDD1A SYTL1

1.23e-0482138451dd9ab3ddb26d3d3395d0c1a156a12a86caf89b
ToppCellChildren_(3_yrs)-Endothelial-endothelial_cell_of_artery-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

HSPG2 PDE3A GIPC2 CDH5 NOTCH4

1.29e-041571385275a4c6fef1fff8da2bdc48e3924ad05c5e5cfc8
ToppCelldroplet-Liver-HEPATOCYTES-1m-Myeloid-Kupffer_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CPLANE2 MAN2B2 GANC LNPEP C2

1.29e-041571385b527e88382c8d21188a0f222b3302523e8816dfc
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MASP1 CTTNBP2 NOP16 DNLZ CRB2

1.33e-041581385e7db0ee4740e3c7a4d97d7cd7462e2c2ab458a4b
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MASP1 CTTNBP2 NOP16 DNLZ CRB2

1.33e-041581385d39e020c3e77eb9d3de600a171d22f94357061d4
ToppCell3'-GW_trimst-1.5-LargeIntestine-Endothelial-blood_vessel_EC-Fetal_venous_EC|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

EPHB4 HSPG2 PZP CDH5 CRB2

1.41e-04160138533050dc646762dc7e9dcc4a12c618e1ba1ce5a4d
ToppCellGlobus_pallidus-Macroglia-POLYDENDROCYTE-P1-Tnr|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

SAPCD1 CHRNG CORIN ADGRF1

1.42e-04851384159b3ac93490c3e4918ea61f8ede7add9e63ca40
ToppCellHippocampus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)|Hippocampus / BrainAtlas - Mouse McCarroll V32

RELN ZNF618 CORIN UNC5D MYO16

1.46e-041611385b81b346309f3facbfbebd91cae4c5b33c7bd24ef
ToppCellkidney_cells-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell_prolif|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

BLM SPTBN5 CDH5 NOTCH1 NOTCH4

1.54e-0416313851feb4ef7b8abcfca9a72c8d13c40548de79e7db2
ToppCellfacs-Kidney-nan-24m-Mesenchymal-mesangial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PDE3A CCDC85C AEBP1 CNTFR CRB2

1.63e-0416513854cdd80580d5638fd649280ba3893251c2f898f3f
ToppCellfacs-Kidney-nan-24m-Mesenchymal-mesangial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PDE3A CCDC85C AEBP1 CNTFR CRB2

1.63e-041651385c746bb22ef52d7f7fa6ee9c37ae6bbe0ccce718e
ToppCellcritical-Myeloid-Mast_cell|critical / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

PDE3A CTTNBP2 AEBP1 MYO16 IL9R

1.63e-04165138534a1cc6ccd46c059354e8fbde1ac69f202695a4e
ToppCellEndothelial-endothelial_cell_of_bronchial_vessel|World / Lineage, Cell type, age group and donor

GALNT15 GIPC2 RALGAPA2 CDH5 NOTCH4

1.63e-04165138584e553d699ac56df89a77248f7308b9133e1b683
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell_prolif|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

GIPC2 RALGAPA2 BLM HMCN2 NOTCH4

1.68e-0416613858e2faca6a2e76a625de04d6098aa6f98911945c6
ToppCellNS-critical-d_07-13-Myeloid-Mast_cell|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

PDE3A CTTNBP2 AEBP1 MYO16 IL9R

1.73e-0416713858a14fd980d8ebe8ef0216221f619d31aaa27ff15
ToppCellfrontal_cortex-Non-neuronal-leptomeningeal_cell-VLMC-VLMC_Osr1_Mc5r|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

ANPEP LAMA1 AEBP1 C2 CDH5

1.78e-0416813859930bd63b60c03f0152838a79eef77da1c2dd8e5
ToppCellB_cells-pDCs|World / Immune cells in Kidney/Urine in Lupus Nephritis

HSPG2 ZFAT AEBP1 NOTCH4 LILRA4

1.78e-041681385dc8f94424f60ab56facdcffa969e7f3466ee1b6e
ToppCellCOVID-19-Heart-CM_+_Macrophage|COVID-19 / Disease (COVID-19 only), tissue and cell type

PDE3A MYOM3 BCO2 DUSP29 ANKRD2

1.88e-0417013853f15242a1d3e4e9871d9170b2ef05842fb609c29
ToppCellfacs-Lung-nan-3m-Endothelial-Vein_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PDE3A ERAP1 B3GNT3 RALGAPA2 TUBGCP5

1.88e-0417013858e1f757ed62218c0fb6525f49d142dd2cd29acf9
ToppCellfacs-Lung-nan-3m-Endothelial-vein_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PDE3A ERAP1 B3GNT3 RALGAPA2 TUBGCP5

1.88e-04170138567d7e1da3ebd2d14cb2e67799e94d655027ed5c4
ToppCellEndothelial-A-IPF_03|World / lung cells shred on cell class, cell subclass, sample id

HSPG2 MASP1 GIPC2 CDH5 NOTCH4

1.98e-041721385a3201773a25832e92dd113fad165f1ecd37f5e91
ToppCell3'-GW_trimst-1.5-SmallIntestine-Neuronal-Glial_immature-ENCC/glia_Progenitor|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

GALNT15 PCSK2 CHST10 ZFAT LAMA1

2.04e-04173138523e50492bc673aff9df95d97f0b9be4ce57cbf01
ToppCellcritical-Myeloid-pDC|critical / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

ZFAT AEBP1 ALDH1L2 SDF2L1 LILRA4

2.04e-041731385e8508c3efbe0f0fae51484a5535d43103c810d4e
ToppCell3'-Broncho-tracheal-Endothelial-Blood_vessel_EC-pulmonary_artery_endothelial_cell-EC_arterial-EC_arterial_L.2.4.0.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

HSPG2 GIPC2 MYOM3 CDH5 NOTCH4

2.09e-04174138518ab52d8bbca0507fee220e0c4fc765fc47dda34
ToppCellAdult-Endothelial-endothelial_cell_of_vein-D231|Adult / Lineage, Cell type, age group and donor

EPHB4 HSPG2 MASP1 CDH5 NOTCH4

2.09e-0417413852dd647c4fdf99fd1f7b838efef01baf2cbc3446d
DrugSulfamethoxazole [723-46-6]; Up 200; 15.8uM; MCF7; HT_HG-U133A

PARP11 HSPG2 PDE3B TRAF3IP1 RGS12 PPP4R4 ZCCHC4 AP2A2 SAFB2

3.12e-0619713794690_UP
Drug5-DMA

MYLK PCSK7 C2 CDH5

4.53e-06191374CID000001793
Drugiminocyclitol

MAN2B2 ABO GANC

7.33e-0671373CID011298136
Drugdiisopropylfluorophosphate

PCSK2 MASP1 ANPEP ERAP1 PLA2G3 AEBP1 ERAP2 LNPEP PCSK7 CORIN

2.55e-0532113710CID000005936
Drug6-Furfurylaminopurine [525-79-1]; Down 200; 18.6uM; PC3; HT_HG-U133A

HSPG2 TRAF3IP1 CCDC85C ABCA7 RNF6 SNAPC4 CFAP69 MVP

2.63e-0519713784477_DN
DrugSulfanilamide [63-74-1]; Down 200; 23.2uM; HL60; HT_HG-U133A

EPHB4 HSPG2 HDAC5 ERAP1 CCDC85C PPP4R4 RHOBTB1 ATG9A

2.63e-0519713782709_DN
DrugMelatonin [73-31-4]; Down 200; 17.2uM; MCF7; HT_HG-U133A

PDE3B HDAC5 RGS12 SPTBN5 ZCCHC4 AEBP1 PCSK7 MVP

2.72e-0519813785393_DN
DrugSulfathiazole [72-14-0]; Up 200; 15.6uM; MCF7; HT_HG-U133A

B3GNT3 CHRNB1 SPTBN5 ZNF749 USP48 MVP INVS LILRA4

2.93e-0520013784769_UP
DrugInocor (TN)

PDE3A PDE3B

3.59e-0521372CID000656683
DrugRS-1893

PDE3A PDE3B

3.59e-0521372CID000128386
Drugmethylcyclohexanone

ANPEP C2

3.59e-0521372CID000011525
DrugNSC-293162

PDE3A PDE3B CHRNB1 C2

7.90e-05381374CID000004675
Drugmaltohexaose

TRPC7 ABO HDAC4 GANC

8.76e-05391374CID000439606
Drugmaltoheptose

ABO HDAC4 GANC PCSK7

9.69e-05401374CID003037125
DrugSureCN4406168

PDE3A PDE3B

1.07e-0431372CID011502028
DrugSureCN4395097

PDE3A PDE3B

1.07e-0431372CID011610011
DrugSureCN4401117

PDE3A PDE3B

1.07e-0431372CID011718172
DrugSureCN4402206

PDE3A PDE3B

1.07e-0431372CID011516917
DrugWIN 62582

PDE3A PDE3B

1.07e-0431372CID005487388
DrugSureCN4397066

PDE3A PDE3B

1.07e-0431372CID011538627
DrugSureCN4401121

PDE3A PDE3B

1.07e-0431372CID011611819
DrugSureCN4404748

PDE3A PDE3B

1.07e-0431372CID011502895
DrugSureCN4411688

PDE3A PDE3B

1.07e-0431372CID011523192
DrugSureCN4405038

PDE3A PDE3B

1.07e-0431372CID011546172
DrugSureCN4405912

PDE3A PDE3B

1.07e-0431372CID011682920
Drugpelrinone

PDE3A PDE3B

1.07e-0431372CID000055919
DrugSureCN4398032

PDE3A PDE3B

1.07e-0431372CID011532088
DrugSureCN4406373

PDE3A PDE3B

1.07e-0431372CID011711104
DrugSureCN4394894

PDE3A PDE3B

1.07e-0431372CID011711103
DrugSureCN5995113

PDE3A PDE3B

1.07e-0431372CID011640499
DrugCHEMBL219123

PDE3A PDE3B

1.07e-0431372CID016102624
Druggermitrine

PDE3A PDE3B

1.07e-0431372CID000011217
DrugSureCN4411840

PDE3A PDE3B

1.07e-0431372CID011567407
DrugSureCN4401113

PDE3A PDE3B

1.07e-0431372CID011544858
DrugSureCN4405883

PDE3A PDE3B

1.07e-0431372CID011516351
DrugSureCN4407211

PDE3A PDE3B

1.07e-0431372CID011553351
DrugSureCN4401096

PDE3A PDE3B

1.07e-0431372CID011710801
Diseaseendoplasmic reticulum aminopeptidase 1 measurement

ERAP1 ERAP2 LNPEP

3.02e-0671323EFO_0008119
Diseasesevere pre-eclampsia (is_marker_for)

ERAP1 ERAP2 LNPEP

4.82e-0681323DOID:13129 (is_marker_for)
Diseasehemangiopericytoma (is_marker_for)

EPHB4 NOTCH1 NOTCH4

7.21e-0691323DOID:264 (is_marker_for)
DiseaseRenal dysplasia and retinal aplasia (disorder)

TRAF3IP1 CEP164 INVS

1.87e-05121323C0403553
Diseaseendoplasmic reticulum aminopeptidase 2 measurement

ERAP2 LNPEP

1.99e-0521322EFO_0801566
DiseaseCongenital aneurysm of ascending aorta

MYLK NOTCH1

1.99e-0521322C0345050
Diseasecomplement factor D measurement

MASP1 ZFAT CTTNBP2 ABO PIKFYVE

6.29e-05931325EFO_0020283
Diseaseneurogenic locus notch homolog protein 1 measurement

ABO NOTCH1

1.97e-0451322EFO_0008246
Diseasecadherin-5 measurement

ABO CDH5

1.97e-0451322EFO_0008060
Diseaseurate measurement, body mass index

ERAP1 RNF6 ERAP2

3.25e-04301323EFO_0004340, EFO_0004531
DiseasePulmonary Hypertension, Primary, 1, With Hereditary Hemorrhagic Telangiectasia

HDAC5 HDAC4

4.11e-0471322C3714844
DiseasePulmonary Hypertension, Primary, 1

HDAC5 HDAC4

4.11e-0471322C4552070
DiseasePULMONARY HYPERTENSION, PRIMARY, DEXFENFLURAMINE-ASSOCIATED

HDAC5 HDAC4

4.11e-0471322C1969342
DiseasePulmonary Hypertension, Primary, Fenfluramine-Associated

HDAC5 HDAC4

4.11e-0471322C1969343
DiseaseAcute lymphocytic leukemia

BLM NOTCH1

4.11e-0471322C0023449
Diseasecalcium measurement

PDE3A GIPC2 ABO HDAC4 RNF217 RGS12 PPP4R4 EIF2B4 L3MBTL3 GOLGB1

5.43e-0462813210EFO_0004838
Diseasetestosterone measurement

GALNT15 TRPC7 STARD8 ABO DCDC1 CCDC85C PKDREJ CHRNB1 EIF2B4 C2 USP48 L3MBTL3 UNC5D MYO16 CNTFR

5.97e-04127513215EFO_0004908
Diseaseulcerative colitis

EPHB4 ZGPAT DUSP29 ERAP2 SNAPC4 NOTCH1 NOTCH4

8.02e-043351327EFO_0000729
Disease3-phenylpropionate hydrocinnamate measurement

LAMA1 RNF115

8.73e-04101322EFO_0021010
Diseaseornithine measurement

GALNT15 ABO HDAC4

1.01e-03441323EFO_0009776
Diseaseapolipoprotein B to apolipoprotein A1 ratio

ABO CERT1 PCSK7

1.39e-03491323EFO_0021897
Diseasecomplex trait

EPHB4 GIPC2 ABO EIF2B4 PCSK7 ZSCAN16

1.42e-032711326EFO_0010578
Diseaselean body mass

PDE3A ZFAT GIPC2 RHOBTB1 C2 L3MBTL3 METTL2B

1.63e-033791327EFO_0004995
DiseaseMajewski Syndrome

IFT140 TRAF3IP1

1.74e-03141322C0024507
Diseaseinterleukin-1 beta measurement

PCSK2 BCO2 METTL2B

1.84e-03541323EFO_0004812
Diseaseurate measurement, bone density

PDE3B ACTR5 ZNF618 CLASP2 RHOBTB1 RNF6 C2 MYO16 NOTCH4

1.92e-036191329EFO_0003923, EFO_0004531
Diseasecancer biomarker measurement

ABO B3GNT3

2.01e-03151322EFO_0005127
DiseaseMyasthenic Syndromes, Congenital, Slow Channel

CHRNB1 CHRNG

2.29e-03161322C0751885
Diseasecongenital myasthenic syndrome (implicated_via_orthology)

CHRNB1 CHRNG

2.29e-03161322DOID:3635 (implicated_via_orthology)
DiseaseIdiopathic pulmonary arterial hypertension

HDAC5 HDAC4

2.29e-03161322C3203102
DiseaseMammary Carcinoma, Human

EPHB4 STARD8 ZSWIM5 RNF115 L3MBTL3 CDH5 NOTCH1 NOTCH4

2.56e-035251328C4704874
DiseaseMammary Neoplasms, Human

EPHB4 STARD8 ZSWIM5 RNF115 L3MBTL3 CDH5 NOTCH1 NOTCH4

2.56e-035251328C1257931
Diseaseproprotein convertase subtilisin/kexin type 7 measurement

CEP164 PCSK7

2.58e-03171322EFO_0008270
DiseaseCongenital Myasthenic Syndromes, Postsynaptic

CHRNB1 CHRNG

2.58e-03171322C0751883
Diseasethrombomodulin measurement

ABO LAMA1

2.58e-03171322EFO_0007774
DiseaseFamilial primary pulmonary hypertension

HDAC5 HDAC4

2.58e-03171322C0340543
DiseaseMammary Neoplasms

EPHB4 STARD8 ZSWIM5 RNF115 L3MBTL3 CDH5 NOTCH1 NOTCH4

2.62e-035271328C1458155
DiseaseBreast Carcinoma

EPHB4 STARD8 ZSWIM5 RNF115 L3MBTL3 CDH5 NOTCH1 NOTCH4

2.97e-035381328C0678222
DiseaseX-11470 measurement

C2 NOTCH4

3.23e-03191322EFO_0021241
DiseaseCongenital Myasthenic Syndromes, Presynaptic

CHRNB1 CHRNG

3.23e-03191322C0751884
Diseasevery low density lipoprotein cholesterol measurement, cholesterol:total lipids ratio

PDE3A ABO CERT1 RGS12 PCSK7

3.29e-032221325EFO_0008317, EFO_0020943
Diseasecholesterol to total lipids in very small VLDL percentage

ABO CERT1 RGS12

3.40e-03671323EFO_0022245
Diseasetriglycerides:total lipids ratio, very low density lipoprotein cholesterol measurement

PDE3A ABO CERT1 RGS12 PCSK7

3.48e-032251325EFO_0008317, EFO_0020947
DiseaseFEV/FEC ratio

HSPG2 PDE3A CTTNBP2 GIPC2 HDAC4 ZSCAN31 TRAF3IP1 CCDC85C SPTBN5 ANKDD1A L3MBTL3 MYO16 CRB2

3.49e-03122813213EFO_0004713
Diseasemaximal midexpiratory flow rate

GALNT15 MYO16

3.58e-03201322EFO_0004313
DiseaseLeber Congenital Amaurosis

IFT140 NMNAT1

4.33e-03221322C0339527
DiseaseTakayasu arteritis

EPHB4 SAPCD1 SNAPC4 NOTCH4

4.47e-031481324EFO_1001857

Protein segments in the cluster

PeptideGeneStartEntry
QCGHSADRHNAEAWK

AGBL5

376

Q8NDL9
HTADVQLHAWGDTLE

ZBTB8OS

36

Q8IWT0
QWASLAANHTRHDQE

CEP170

586

Q5SW79
HAAAQEHAWKEIQRF

BAAT

391

Q14032
DQANGIEAVWHDESH

ABO

291

P16442
HLQWNDAGCHLVNET

ADGRF1

541

Q5T601
WQNPGEETHVEAREH

AEBP1

206

Q8IUX7
VWTELQDIHDAHGLR

AFTPH

701

Q6ULP2
ARHQQSHFDNGNEEW

CHRNG

451

P07510
DQSAEVLHNWIRGHD

ALDH1L2

236

Q3SY69
RHPLFSDVDWENLQH

MASTL

831

Q96GX5
GEWTARVVHLLNDQH

AP2A1

186

O95782
HIHEGTFIENGQWEI

CHRNB1

196

P11230
RHSLLHLQGAIEDWN

ADPRM

46

Q3LIE5
HIESINGENIVGWRH

GIPC2

161

Q8TF65
AQVRALSWGIDHHVF

EEF1AKMT3

126

Q96AZ1
IAHELAHQWFGNLVT

ANPEP

386

P15144
GARDWALNHLDDNEV

ACTR5

536

Q9H9F9
ADGTIWCSHENLHQE

BCO2

441

Q9BYV7
VHDVNDNWPVFTHRL

CDH5

141

P33151
WQDAHADVGHLVGTL

ABCA7

386

Q8IZY2
GDWTSRVVHLLNDQH

AP2A2

186

O94973
SWVAEDHQGAQHTAN

PZP

431

P20742
WGDAFKRAVHAHVNL

NIPSNAP3A

161

Q9UFN0
QVQFSEEHWVHESGR

HSPG2

661

P98160
DDHRVKVHFDGWNNC

L3MBTL3

501

Q96JM7
DPDHRQQWIDAIEQH

CERT1

101

Q9Y5P4
GHLDQLAALHWVQDN

CES1P1

191

Q9UKY3
AWTTAHQEHGRNLAE

DCDC1

796

M0R2J8
GSHQRWIHQEDSRTF

DCDC1

1206

M0R2J8
GIRWEAEAHHDQKLF

FAM86B2

301

P0C5J1
WHSENRQHAEALQQE

TRAF3IP1

621

Q8TDR0
RIWVHNCHIGDAFSE

LOXL3

721

P58215
EEGDHRLSWTLNSHQ

LILRA4

156

P59901
WLHNGNEIQESEDFH

MYLK

656

Q15746
DQTDHRQWTQQHLDA

NOTCH1

1836

P46531
IVDWDVHHGNGTQQA

HDAC4

836

P56524
EHHSQTQLDESEGWR

EPHB4

521

P54760
EGQDWQQILHHAEPR

MYO16

1811

Q9Y6X6
DLALNDGHWHQVEVV

CRB2

511

Q5IJ48
ITWHRDGIVLQEDAH

HMCN2

3626

Q8NDA2
TERQLLEASQHWDHA

ASPDH

106

A6ND91
LEASQHWDHAVFVAR

ASPDH

111

A6ND91
AHCFRDGNDHSLWRV

C2

506

P06681
HAAGAVWHEVARSQQ

CCDC85C

111

A6NKD9
TEEGLAIHQQHWDFQ

GALNT15

576

Q8N3T1
VAHELAHQWFGNLVT

ERAP1

351

Q9NZ08
QVEAVLAGHEAVRWH

PCSK7

116

Q16549
LAGHEAVRWHSEQRL

PCSK7

121

Q16549
RVAANVLHLSLWGEH

PINK1

501

Q9BXM7
DRSVLENHHAAAAWN

PDE3A

861

Q14432
DRSVLENHHAASAWN

PDE3B

846

Q13370
QKNAIHHGNWEHREL

GANC

526

Q8TET4
SDPARVFHHNAWDNV

METTL2B

26

Q6P1Q9
HAVAEEEARKAHQLW

IMMT

556

Q16891
IIAHELAHQWFGNLV

LNPEP

461

Q9UIQ6
VHGHLWDGAREFIIQ

TUBGCP5

481

Q96RT8
GNDEVHIVWSEHSRD

RALGAPA2

1741

Q2PPJ7
KRGEHVALANWQNHA

EIF2B4

466

Q9UI10
HQDSWNGLSHEAFRL

HSPA9

26

P38646
EEKVSHQAGDHWLIR

MVP

346

Q14764
AHVAGHIDFDDLNWQ

RDH13

176

Q8NBN7
NGTGHDQWALDHVEV

RELN

3411

P78509
RDPARVFHHNAWDNV

METTL2A

26

Q96IZ6
IHNFDWRINGIHGAV

PARP11

216

Q9NR21
LHNRAEDWEVKAHQA

CEP135

886

Q66GS9
DVAHILNGLAEQLWH

CPLANE2

226

Q9BU20
GWHHNNLELLREENG

PIKFYVE

586

Q9Y2I7
QLWQADTRHALEHPE

ANKRD2

321

Q9GZV1
QHAHDEDIPWGIQLA

ICE1

2201

Q9Y2F5
EAHCVSQWGHDFRQD

BLM

796

P54132
QWAENVENHPEVAAH

LINC01599

71

Q8WXQ3
FTHVLNAAHGRWNVD

DUSP29

81

Q68J44
HHIIADNLGWFSDLN

DNLZ

106

Q5SXM8
INHANREGWTAAHIA

CTTNBP2

906

Q8WZ74
HWQGNAHRSQTRDEF

ATG9A

451

Q7Z3C6
LDQWQHVELSDGTAH

CNTFR

251

P26992
AVALTDSVHNVWHQE

FAM172A

316

Q8WUF8
ARGLEARWHDESHLN

A3GALT2

281

U3KPV4
RLQHCAWQAVEHADG

CCDC78

246

A2IDD5
RAATEHHVCADGWQE

CORIN

706

Q9Y5Q5
EAQTHGDILQWDFHD

B3GNT3

166

Q9Y2A9
ASLRFEHRDLHWGNV

HASPIN

641

Q8TF76
RWAVSEVQHHDAITG

MAN2B2

411

Q9Y2E5
HWRLRSDENEQHLGV

MASP1

521

P48740
RVIAHELAHQWFGNL

ERAP2

366

Q6P179
ETVLAGHENWVNAVH

ELP2

276

Q6IA86
IVDWDIHHGNGTQQA

HDAC5

866

Q9UQL6
WSAAQHEELQLHAIA

CFAP69

411

A5D8W1
AAGRWQEALQVAEHH

IFT140

881

Q96RY7
GENHSRALLDQVEHW

IPO13

316

O94829
GLRAQWEDHHLQDLQ

ATP4A

896

P20648
FNAQGEIWLAIHHFE

OGT

201

O15294
HIENWHSILRNGLVN

PARP6

476

Q2NL67
VDLVDQDGHSLLHWA

INVS

416

Q9Y283
QEDWNEHLLQVHIAS

GARIN1A

286

Q6NXP2
GDWFQEARSQRHHNA

SYTL1

81

Q8IYJ3
RANERGHQTHTDFWG

RNF115

101

Q9Y4L5
HLEHRDTGVSNAWLE

PPP4R4

141

Q6NUP7
IHELGHNQQRHGWEF

TCAF2

756

A6NFQ2
GDIHSIRVWHNNEGR

PKDREJ

1291

Q9NTG1
IDDNRWHSIHVARFG

LAMA1

2196

P25391
QGDDDHNWKIAHVVL

MEP1A

381

Q16819
LPQDHNHHENERRWQ

RNF6

16

Q9Y252
LELAQFHNAHQLAAW

RHOBTB1

601

O94844
LRHWASEIEHGQRNA

RNF217

406

Q8TC41
LELLQHGQAWFEDHL

SAPCD1

56

Q5SSQ6
HGQAWFEDHLREAQR

SAPCD1

61

Q5SSQ6
AWEQAQHRDHIVGVT

IL9R

191

Q01113
HAWDHAKSVRQNLAE

NOP16

41

Q9Y3C1
LAPADVAHQRNHWDL

NOTCH4

1801

Q99466
DAQGLALIHARWDAH

PLA2G3

51

Q9NZ20
AHLDDILQHVWGLQQ

STARD8

306

Q92502
NHQAWLHLDNLGEDV

SPTBN5

1226

Q9NRC6
ALHWAAGAGHEQAVR

ANKDD1A

51

Q495B1
QHWRHELASAQEVAK

CEP164

1136

Q9UPV0
DPNHRWLDLQFGDHI

CHST10

246

O43529
QEWQTHSLERHAAVL

CLASP2

241

O75122
ATTIANHWRIHNEER

ZNF845

591

Q96IR2
HQQEAVWELLHTEAS

PLEKHG5

336

O94827
NAHWEHGDLRFTRIQ

UHRF1BP1L

156

A0JNW5
VVVEDLHSGAQQHWS

WDR90

1141

Q96KV7
KNGSDLQRHIWAHEG

ZFAT

891

Q9P243
AIEGRELHWQDSHLQ

ZSWIM5

491

Q9P217
QAWVREHHPESGEEA

ZSCAN31

96

Q96LW9
ADIRDSGDLVHHWVQ

ZNF618

586

Q5T7W0
SGDLVHHWVQNVLSE

ZNF618

591

Q5T7W0
EWGILNDAQRHLHSN

ZNF749

21

O43361
HVLREWQCGHTSDQD

RGS12

541

O14924
GQHWEREAAVRFQHV

SDF2L1

151

Q9HCN8
NHAAIWRIILGNEHI

PSTK

311

Q8IV42
AARLHQGAEELGAEW

SPTBN4

1056

Q9H254
DWGEHNQRLEEHQAR

SAFB2

846

Q14151
ILNLWEARHQHDGDL

UNC5D

901

Q6UXZ4
DLQAWVRAHHPETGE

ZSCAN16

96

Q9H4T2
DWGQHSEHQVLGNVS

ZCCHC4

136

Q9H5U6
QAIAAAHGHLEWQKI

SNAPC4

306

Q5SXM2
HIWLGEIDENSFHNI

USP48

61

Q86UV5
AKHQDGLWHAARITD

ZGPAT

226

Q8N5A5
EWGILNDVQRHLHSD

ZNF17

21

P17021
LNGDVNFQVWSDHHR

TRPC7

291

Q9HCX4
EELRQENLSWQHELH

GOLGB1

2936

Q14789
LDQHDSEELDWHAVN

MYOM3

736

Q5VTT5
QLHDEVHQWRRNGVG

PCSK2

421

P16519
HRSNIHVVNEWIAND

NMNAT1

206

Q9HAN9