Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	I-kappaB/NF-kappaB complex	NFKB1 NFKB2	3.77e-05	4	53	2	GO:0033256
MousePheno	thin neurocranium	NELL1 FGFRL1 MN1	2.14e-05	18	43	3	MP:0030279
MousePheno	thin interparietal bone	NELL1 MN1	2.77e-05	3	43	2	MP:0030277
MousePheno	thin frontal bone	NELL1 MN1	5.52e-05	4	43	2	MP:0030275
Domain	RHD_CS	NFKB1 NFKB2	7.27e-05	5	51	2	IPR030492
Domain	IPT_NFkappaB	NFKB1 NFKB2	7.27e-05	5	51	2	IPR033926
Domain	RHD_dimer	NFKB1 NFKB2	3.24e-04	10	51	2	IPR032397
Domain	RHD_dimer	NFKB1 NFKB2	3.24e-04	10	51	2	PF16179
Domain	NFkB/Dor	NFKB1 NFKB2	3.24e-04	10	51	2	IPR000451
Domain	REL_1	NFKB1 NFKB2	3.24e-04	10	51	2	PS01204
Domain	RHD_DNA_bind_dom	NFKB1 NFKB2	3.24e-04	10	51	2	IPR011539
Domain	RHD_DNA_bind	NFKB1 NFKB2	3.24e-04	10	51	2	PF00554
Domain	REL_2	NFKB1 NFKB2	3.24e-04	10	51	2	PS50254
Domain	-	NFKB1 NFKB2	3.24e-04	10	51	2	2.60.40.340
Domain	TSP_1	ADAMTS13 ADAMTS8 SSPOP	6.79e-04	63	51	3	PF00090
Domain	TSP1	ADAMTS13 ADAMTS8 SSPOP	7.44e-04	65	51	3	SM00209
Domain	TSP1_rpt	ADAMTS13 ADAMTS8 SSPOP	7.44e-04	65	51	3	IPR000884
Domain	TSP1	ADAMTS13 ADAMTS8 SSPOP	7.44e-04	65	51	3	PS50092
Domain	VWC_out	NELL1 SSPOP	1.21e-03	19	51	2	SM00215
Domain	Peptidase_M12B_ADAM-TS	ADAMTS13 ADAMTS8	1.94e-03	24	51	2	IPR013273
Domain	IPT	NFKB1 NFKB2	2.46e-03	27	51	2	SM00429
Domain	ACR	ADAMTS13 ADAMTS8	2.46e-03	27	51	2	SM00608
Domain	ADAM_Cys-rich	ADAMTS13 ADAMTS8	2.46e-03	27	51	2	IPR006586
Domain	DEATH	NFKB1 NFKB2	2.46e-03	27	51	2	SM00005
Domain	IPT	NFKB1 NFKB2	3.44e-03	32	51	2	IPR002909
Domain	Death	NFKB1 NFKB2	3.66e-03	33	51	2	PF00531
Domain	VWFC_1	NELL1 SSPOP	4.34e-03	36	51	2	PS01208
Domain	Death_domain	NFKB1 NFKB2	4.83e-03	38	51	2	IPR000488
Domain	VWC	NELL1 SSPOP	4.83e-03	38	51	2	SM00214
Domain	VWFC_2	NELL1 SSPOP	4.83e-03	38	51	2	PS50184
Domain	DEATH_DOMAIN	NFKB1 NFKB2	4.83e-03	38	51	2	PS50017
Domain	DISINTEGRIN_1	ADAMTS13 ADAMTS8	5.34e-03	40	51	2	PS00427
Domain	Reprolysin	ADAMTS13 ADAMTS8	5.34e-03	40	51	2	PF01421
Domain	ADAM_MEPRO	ADAMTS13 ADAMTS8	5.34e-03	40	51	2	PS50215
Domain	DISINTEGRIN_2	ADAMTS13 ADAMTS8	5.34e-03	40	51	2	PS50214
Domain	Peptidase_M12B	ADAMTS13 ADAMTS8	5.34e-03	40	51	2	IPR001590
Domain	Disintegrin_dom	ADAMTS13 ADAMTS8	5.60e-03	41	51	2	IPR001762
Domain	VWF_dom	NELL1 SSPOP	5.87e-03	42	51	2	IPR001007
Domain	ARM-like	SF3B1 ARVCF MN1 MED12	6.27e-03	270	51	4	IPR011989
Domain	PDZ	SHROOM2 PREX1 PDZD2	7.69e-03	148	51	3	SM00228
Domain	-	SHROOM2 PREX1 PDZD2	7.98e-03	150	51	3	2.30.42.10
Domain	PDZ	SHROOM2 PREX1 PDZD2	8.12e-03	151	51	3	PS50106
Pathway	REACTOME_DEX_H_BOX_HELICASES_ACTIVATE_TYPE_I_IFN_AND_INFLAMMATORY_CYTOKINES_PRODUCTION	NFKB1 NFKB2	1.80e-04	7	42	2	MM14930
Pathway	REACTOME_IKBA_VARIANT_LEADS_TO_EDA_ID	NFKB1 NFKB2	1.80e-04	7	42	2	M27463
Pathway	REACTOME_DEX_H_BOX_HELICASES_ACTIVATE_TYPE_I_IFN_AND_INFLAMMATORY_CYTOKINES_PRODUCTION	NFKB1 NFKB2	1.80e-04	7	42	2	M27227
Pathway	REACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS	ADAMTS13 ADAMTS8 SSPOP	2.09e-04	39	42	3	M27417
Pathway	REACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS	ADAMTS13 ADAMTS8 SSPOP	2.09e-04	39	42	3	MM15165
Pathway	REACTOME_INTERLEUKIN_1_PROCESSING	NFKB1 NFKB2	3.08e-04	9	42	2	M27383
Pathway	REACTOME_INTERLEUKIN_1_PROCESSING	NFKB1 NFKB2	3.08e-04	9	42	2	MM15129
Pubmed	Fbxw7α- and GSK3-mediated degradation of p100 is a pro-survival mechanism in multiple myeloma.	BCL2L11 NFKB1 NFKB2	2.07e-06	16	55	3	22388891
Pubmed	Related subunits of NF-kappa B map to two distinct loci associated with translocations in leukemia, NFKB1 and NFKB2.	NFKB1 NFKB2	2.46e-06	2	55	2	1612589
Pubmed	The role of NF-{kappa}B-1 and NF-{kappa}B-2-mediated resistance to apoptosis in lymphomas.	NFKB1 NFKB2	2.46e-06	2	55	2	16751281
Pubmed	Quantitative dissection and modeling of the NF-κB p100-p105 module reveals interdependent precursor proteolysis.	NFKB1 NFKB2	2.46e-06	2	55	2	25482563
Pubmed	Prognostic interaction between bone marrow morphology and SF3B1 and ASXL1 mutations in myelodysplastic syndromes with ring sideroblasts.	ASXL1 SF3B1	2.46e-06	2	55	2	29434284
Pubmed	Molecular impact of selective NFKB1 and NFKB2 signaling on DLBCL phenotype.	NFKB1 NFKB2	2.46e-06	2	55	2	28368397
Pubmed	Monitoring a nuclear factor-κB signature of drug resistance in multiple myeloma.	NFKB1 NFKB2	2.46e-06	2	55	2	21846842
Pubmed	Expression of either NF-kappaB p50 or p52 in osteoclast precursors is required for IL-1-induced bone resorption.	NFKB1 NFKB2	2.46e-06	2	55	2	12568403
Pubmed	NF-kappa B binds to the immunoglobulin S gamma 3 region in vivo during class switch recombination.	NFKB1 NFKB2	2.46e-06	2	55	2	17109470
Pubmed	Requirement for NF-kappaB in osteoclast and B-cell development.	NFKB1 NFKB2	2.46e-06	2	55	2	9407039
Pubmed	NF-kappaB to the rescue: RELs, apoptosis and cellular transformation.	NFKB1 NFKB2	2.46e-06	2	55	2	10354583
Pubmed	Osteoclast precursor interaction with bone matrix induces osteoclast formation directly by an interleukin-1-mediated autocrine mechanism.	NFKB1 NFKB2	2.46e-06	2	55	2	18250170
Pubmed	New insights into the role of nuclear factor-kappaB, a ubiquitous transcription factor in the initiation of diseases.	NFKB1 NFKB2	2.46e-06	2	55	2	9895331
Pubmed	Analysis of NFKB1 and NFKB2 gene expression in the blood of patients with sudden sensorineural hearing loss.	NFKB1 NFKB2	2.46e-06	2	55	2	36773447
Pubmed	How do nuclear factor kappa B (NF-κB)1 and NF-κB2 defects lead to the incidence of clinical and immunological manifestations of inborn errors of immunity?	NFKB1 NFKB2	2.46e-06	2	55	2	36706462
Pubmed	NF-{kappa}B is transported into the nucleus by importin {alpha}3 and importin {alpha}4.	NFKB1 NFKB2	2.46e-06	2	55	2	15677444
Pubmed	Osteopetrosis in mice lacking NF-kappaB1 and NF-kappaB2.	NFKB1 NFKB2	2.46e-06	2	55	2	9359707
Pubmed	Bcl11b is required for differentiation and survival of alphabeta T lymphocytes.	BCL2L11 NFKB1 NFKB2	4.19e-06	20	55	3	12717433
Pubmed	NF-kappaB p50 and p52 expression is not required for RANK-expressing osteoclast progenitor formation but is essential for RANK- and cytokine-mediated osteoclastogenesis.	NFKB1 NFKB2	7.36e-06	3	55	2	12096833
Pubmed	Dimerization of NF-KB2 with RelA(p65) regulates DNA binding, transcriptional activation, and inhibition by an I kappa B-alpha (MAD-3).	NFKB1 NFKB2	7.36e-06	3	55	2	8441377
Pubmed	Differential requirement for NF-kappa B family members in control of helminth infection and intestinal inflammation.	NFKB1 NFKB2	7.36e-06	3	55	2	12370384
Pubmed	Cell-autonomous role for NF-kappa B in immature bone marrow B cells.	NFKB1 NFKB2	7.36e-06	3	55	2	19265118
Pubmed	Nuclear transcription factor-kappaB as a target for cancer drug development.	NFKB1 NFKB2	7.36e-06	3	55	2	12040437
Pubmed	The NF-kappa B and I kappa B proteins: new discoveries and insights.	NFKB1 NFKB2	7.36e-06	3	55	2	8717528
Pubmed	Genetic landscape of recurrent ASXL1, U2AF1, SF3B1, SRSF2, and EZH2 mutations in 304 Chinese patients with myelodysplastic syndromes.	ASXL1 SF3B1	7.36e-06	3	55	2	26508027
Pubmed	Motif module map reveals enforcement of aging by continual NF-kappaB activity.	NFKB1 NFKB2	7.36e-06	3	55	2	18055696
Pubmed	1,25-Dihydroxyvitamin D3 targeting of NF-kappaB suppresses high glucose-induced MCP-1 expression in mesangial cells.	NFKB1 NFKB2	7.36e-06	3	55	2	17507908
Pubmed	Modulation of T-cell activation by the glucocorticoid-induced leucine zipper factor via inhibition of nuclear factor kappaB.	NFKB1 NFKB2	7.36e-06	3	55	2	11468175
Pubmed	NF-κB: an essential transcription factor in psoriasis.	NFKB1 NFKB2	7.36e-06	3	55	2	23219896
Pubmed	NFkappaB1/p50 is not required for tumor necrosis factor-stimulated growth of primary mammary epithelial cells: implications for NFkappaB2/p52 and RelB.	NFKB1 NFKB2	7.36e-06	3	55	2	17008396
Pubmed	Coordination between NF-kappaB family members p50 and p52 is essential for mediating LTbetaR signals in the development and organization of secondary lymphoid tissues.	NFKB1 NFKB2	7.36e-06	3	55	2	16195333
Pubmed	Constitutive production of NF-kappaB2 p52 is not tumorigenic but predisposes mice to inflammatory autoimmune disease by repressing Bim expression.	BCL2L11 NFKB2	7.36e-06	3	55	2	18281283
Pubmed	Signaling mediated by the NF-κB sub-units NF-κB1, NF-κB2 and c-Rel differentially regulate Helicobacter felis-induced gastric carcinogenesis in C57BL/6 mice.	NFKB1 NFKB2	7.36e-06	3	55	2	23975431
Pubmed	[The Rel/NF-kappa-B transcription factors: complex role in cell regulation].	NFKB1 NFKB2	7.36e-06	3	55	2	11980335
Pubmed	CD40 Signaling in Graves Disease Is Mediated Through Canonical and Noncanonical Thyroidal Nuclear Factor κB Activation.	NFKB1 NFKB2	7.36e-06	3	55	2	27929668
Pubmed	Mice lacking NF-κB1 exhibit marked DNA damage responses and more severe gastric pathology in response to intraperitoneal tamoxifen administration.	NFKB1 NFKB2	7.36e-06	3	55	2	28726772
Pubmed	Abnormal organogenesis of Peyer's patches in mice deficient for NF-kappaB1, NF-kappaB2, and Bcl-3.	NFKB1 NFKB2	7.36e-06	3	55	2	12055593
Pubmed	Fatty acid-induced induction of Toll-like receptor-4/nuclear factor-kappaB pathway in adipocytes links nutritional signalling with innate immunity.	NFKB1 NFKB2	7.36e-06	3	55	2	18624726
Pubmed	Deregulated Levels of the NF-κB1, NF-κB2, and Rel Genes in Ukrainian Patients with Leukemia and Lymphoma in the Post-Chernobyl Period.	NFKB1 NFKB2	7.36e-06	3	55	2	25912249
Pubmed	Lipopolysaccharide from Salmonella enterica activates NF-kappaB through both classical and alternative pathways in primary B Lymphocytes.	NFKB1 NFKB2	7.36e-06	3	55	2	17698569
Pubmed	The relationship between BRAFV600E, NF-κB and TgAb expression in papillary thyroid carcinoma.	NFKB1 NFKB2	7.36e-06	3	55	2	28214213
Pubmed	NF-kappaB specifically activates BMP-2 gene expression in growth plate chondrocytes in vivo and in a chondrocyte cell line in vitro.	NFKB1 NFKB2	7.36e-06	3	55	2	12759356
Pubmed	NF-kappa B p50/p65 affects the frequency of Ly49 gene expression by NK cells.	NFKB1 NFKB2	7.36e-06	3	55	2	17641041
Pubmed	Regulation of secondary lymphoid organ development by the nuclear factor-kappaB signal transduction pathway.	NFKB1 NFKB2	7.36e-06	3	55	2	12969313
Pubmed	Overexpression of MN1 confers resistance to chemotherapy, accelerates leukemia onset, and suppresses p53 and Bim induction.	BCL2L11 MN1	7.36e-06	3	55	2	22905229
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	SH3RF1 HECW1 BRSK2 NTNG1 PREX1 MAML3 MED12	1.24e-05	493	55	7	15368895
Pubmed	NF-κB1, NF-κB2 and c-Rel differentially regulate susceptibility to colitis-associated adenoma development in C57BL/6 mice.	NFKB1 NFKB2	1.47e-05	4	55	2	25727407
Pubmed	Lack of nuclear factor-kappa B2/p100 causes a RelB-dependent block in early B lymphopoiesis.	NFKB1 NFKB2	1.47e-05	4	55	2	18505785
Pubmed	The tumor suppressor protein menin interacts with NF-kappaB proteins and inhibits NF-kappaB-mediated transactivation.	NFKB1 NFKB2	1.47e-05	4	55	2	11526476
Pubmed	Impact of loss of NF-κB1, NF-κB2 or c-REL on SLE-like autoimmune disease and lymphadenopathy in Fas(lpr/lpr) mutant mice.	NFKB1 NFKB2	1.47e-05	4	55	2	26084385
Pubmed	A fourth IkappaB protein within the NF-kappaB signaling module.	NFKB1 NFKB2	1.47e-05	4	55	2	17254973
Pubmed	Specific NF-kappa B subunits act in concert with Tat to stimulate human immunodeficiency virus type 1 transcription.	NFKB1 NFKB2	1.47e-05	4	55	2	1583734
Pubmed	Stimulation of CD30 in anaplastic large cell lymphoma leads to production of nuclear factor-kappaB p52, which is associated with hyperphosphorylated Bcl-3.	NFKB1 NFKB2	1.47e-05	4	55	2	16108830
Pubmed	Characterization of mechanisms involved in transrepression of NF-kappa B by activated glucocorticoid receptors.	NFKB1 NFKB2	1.47e-05	4	55	2	7823959
Pubmed	Activation of noncanonical NF-kappaB signaling by the oncoprotein Tio.	NFKB1 NFKB2	1.47e-05	4	55	2	20353939
Pubmed	Cutting edge: a short polypeptide domain of HIV-1-Tat protein mediates pathogenesis.	NFKB1 NFKB2	1.47e-05	4	55	2	10384093
Pubmed	Activation of transcription factor NF-kappaB by the Tat protein of human immunodeficiency virus type 1.	NFKB1 NFKB2	1.47e-05	4	55	2	8676466
Pubmed	NF-κB2 Controls the Migratory Activity of Memory T Cells by Regulating Expression of CXCR4 in a Mouse Model of Sjögren's Syndrome.	NFKB1 NFKB2	1.47e-05	4	55	2	28804991
Pubmed	Expression of nuclear factor-kappaB family proteins in hepatocellular carcinomas.	NFKB1 NFKB2	1.47e-05	4	55	2	18025803
Pubmed	Fucoidan prevents C epsilon germline transcription and NFkappaB p52 translocation for IgE production in B cells.	NFKB1 NFKB2	1.47e-05	4	55	2	17027924
Pubmed	Chromosomal localization of genes encoding the transcription factors, c-rel, NF-kappa Bp50, NF-kappa Bp65, and lyt-10 by fluorescence in situ hybridization.	NFKB1 NFKB2	1.47e-05	4	55	2	8423996
Pubmed	Absolute dependence on kappa B responsive elements for initiation and Tat-mediated amplification of HIV transcription in blood CD4 T lymphocytes.	NFKB1 NFKB2	1.47e-05	4	55	2	7729429
Pubmed	A CNS-enriched factor that binds to NF-kappa B and is required for interaction with HIV-1 tat.	NFKB1 NFKB2	1.47e-05	4	55	2	7838536
Pubmed	Mutations and karyotype predict treatment response in myelodysplastic syndromes.	ASXL1 SF3B1	1.47e-05	4	55	2	30152885
Pubmed	TAR-independent transactivation by Tat in cells derived from the CNS: a novel mechanism of HIV-1 gene regulation.	NFKB1 NFKB2	1.47e-05	4	55	2	1505523
Pubmed	VEGF-C, a lymphatic growth factor, is a RANKL target gene in osteoclasts that enhances osteoclastic bone resorption through an autocrine mechanism.	NFKB1 NFKB2	1.47e-05	4	55	2	18359770
Pubmed	Alteration of NF-kappaB activity leads to mitochondrial apoptosis after infection with pathological prion protein.	NFKB1 NFKB2	1.47e-05	4	55	2	17573907
Pubmed	mTOR-Dependent and Independent Survival Signaling by PI3K in B Lymphocytes.	BCL2L11 NFKB2	1.47e-05	4	55	2	26785352
Pubmed	Transfection of human endothelial cells with HIV-1 tat gene activates NF-kappa B and enhances monocyte adhesion.	NFKB1 NFKB2	1.47e-05	4	55	2	12427593
Pubmed	NF-kappaB2 is required for the establishment of central tolerance through an Aire-dependent pathway.	NFKB1 NFKB2	1.47e-05	4	55	2	17039258
Pubmed	Proteasome-dependent autoregulation of Bruton tyrosine kinase (Btk) promoter via NF-kappaB.	NFKB1 NFKB2	1.47e-05	4	55	2	18292289
Pubmed	Control of canonical NF-kappaB activation through the NIK-IKK complex pathway.	NFKB1 NFKB2	1.47e-05	4	55	2	18292232
Pubmed	HIV-1 regulatory protein tat induces RNA binding proteins in central nervous system cells that associate with the viral trans-acting-response regulatory motif.	NFKB1 NFKB2	1.47e-05	4	55	2	10225209
Pubmed	Bim and Noxa are candidates to mediate the deleterious effect of the NF-kappa B subunit RelA in cerebral ischemia.	BCL2L11 NFKB2	2.45e-05	5	55	2	17167080
Pubmed	The Nfkb1 and Nfkb2 proteins p105 and p100 function as the core of high-molecular-weight heterogeneous complexes.	NFKB1 NFKB2	2.45e-05	5	55	2	19524538
Pubmed	Activation of nuclear factor-kappaB p50 homodimer/Bcl-3 complexes in nasopharyngeal carcinoma.	NFKB1 NFKB2	2.45e-05	5	55	2	14678988
Pubmed	The cytoplasmic domain of the HIV-1 glycoprotein gp41 induces NF-κB activation through TGF-β-activated kinase 1.	NFKB1 NFKB2	2.45e-05	5	55	2	22341466
Pubmed	Human immunodeficiency virus type 1 tat protein activates transcription factor NF-kappaB through the cellular interferon-inducible, double-stranded RNA-dependent protein kinase, PKR.	NFKB1 NFKB2	2.45e-05	5	55	2	10400814
Pubmed	The NF-kappaB/Rel family of transcription factors in oncogenic transformation and apoptosis.	NFKB1 NFKB2	2.45e-05	5	55	2	10592330
Pubmed	The oncoprotein and transcriptional regulator Bcl-3 governs plasticity and pathogenicity of autoimmune T cells.	NFKB1 NFKB2	2.45e-05	5	55	2	25367572
Pubmed	Constitutive silencing of IFN-beta promoter is mediated by NRF (NF-kappaB-repressing factor), a nuclear inhibitor of NF-kappaB.	NFKB1 NFKB2	2.45e-05	5	55	2	10562553
Pubmed	A new member of the I kappaB protein family, I kappaB epsilon, inhibits RelA (p65)-mediated NF-kappaB transcription.	NFKB1 NFKB2	2.45e-05	5	55	2	9315679
Pubmed	The human immunodeficiency virus-1 Tat protein activates human umbilical vein endothelial cell E-selectin expression via an NF-kappa B-dependent mechanism.	NFKB1 NFKB2	2.45e-05	5	55	2	11827962
Pubmed	The effect of HIV-1 regulatory proteins on cellular genes: derepression of the IL-2 promoter by Tat.	NFKB1 NFKB2	2.45e-05	5	55	2	11385624
Pubmed	Unique CD40-mediated biological program in B cell activation requires both type 1 and type 2 NF-kappaB activation pathways.	NFKB1 NFKB2	2.45e-05	5	55	2	15148378
Pubmed	Genetic approaches in mice to understand Rel/NF-kappaB and IkappaB function: transgenics and knockouts.	NFKB1 NFKB2	2.45e-05	5	55	2	10602464
Pubmed	Selective regulation of a defined subset of inflammatory and immunoregulatory genes by an NF-κB p50-IκBζ pathway.	NFKB1 NFKB2	2.45e-05	5	55	2	38918046
Pubmed	U50,488 inhibits HIV-1 Tat-induced monocyte chemoattractant protein-1 (CCL2) production by human astrocytes.	NFKB1 NFKB2	2.45e-05	5	55	2	12473373
Pubmed	Multiple signals converging on NF-kappaB.	NFKB1 NFKB2	2.45e-05	5	55	2	10209157
Pubmed	The hormone-bound vitamin D receptor enhances the FBW7-dependent turnover of NF-κB subunits.	NFKB1 NFKB2	2.45e-05	5	55	2	26269414
Pubmed	Analysis of variation in NF-kappaB genes and expression levels of NF-kappaB-regulated molecules.	NFKB1 NFKB2	2.45e-05	5	55	2	18466468
Pubmed	Enhanced nuclear factor-kappa B activation induced by tumour necrosis factor-alpha in stably tat-transfected cells is associated with the presence of cell-surface-bound Tat protein.	NFKB1 NFKB2	2.45e-05	5	55	2	8724035
Pubmed	Noncanonical NF-kappaB activation requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2 and TRAF3 and the kinase NIK.	NFKB1 NFKB2	2.45e-05	5	55	2	18997794
Pubmed	The tumor promoter and NF-κB modulator Bcl-3 regulates splenic B cell development.	NFKB1 NFKB2	2.45e-05	5	55	2	24244019
Pubmed	A mouse model of pathological small intestinal epithelial cell apoptosis and shedding induced by systemic administration of lipopolysaccharide.	NFKB1 NFKB2	2.45e-05	5	55	2	24046352
Pubmed	NF-kappaB1 and c-Rel cooperate to promote the survival of TLR4-activated B cells by neutralizing Bim via distinct mechanisms.	BCL2L11 NFKB1	2.45e-05	5	55	2	18805964
Pubmed	The homeoprotein DLX4 stimulates NF-κB activation and CD44-mediated tumor-mesothelial cell interactions in ovarian cancer.	NFKB1 NFKB2	2.45e-05	5	55	2	26067154
Pubmed	Distinctions between c-Rel and other NF-kappaB proteins in immunity and disease.	NFKB1 NFKB2	2.45e-05	5	55	2	12879447
Pubmed	TRAF2 regulates T cell immunity by maintaining a Tpl2-ERK survival signaling axis in effector and memory CD8 T cells.	BCL2L11 NFKB2	2.45e-05	5	55	2	33203937
Pubmed	Fibrillin-2 is a key mediator of smooth muscle extracellular matrix homeostasis during mouse tracheal tubulogenesis.	NFKB1 NFKB2 GOLGA8K	3.55e-05	40	55	3	30578393
GeneFamily	Ataxins\|Trinucleotide repeat containing	TNRC6B MAML3 MED12	1.36e-05	25	34	3	775
GeneFamily	Ankyrin repeat domain containing\|NF-kappa B complex subunits	NFKB1 NFKB2	3.42e-05	5	34	2	1254
GeneFamily	ADAM metallopeptidases with thrombospondin type 1 motif	ADAMTS13 ADAMTS8	5.75e-04	19	34	2	50
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	C2CD4B HECW1	2.08e-03	36	34	2	823
GeneFamily	PDZ domain containing	SHROOM2 PREX1 PDZD2	2.88e-03	152	34	3	1220
GeneFamily	Sterile alpha motif domain containing	SAMD14 SCML4	1.19e-02	88	34	2	760
ToppCell	Macroglial-Polydendrocytes-PDGFRA---\|Macroglial / cells hierarchy compared to all cells using T-Statistic	NELL1 HECW1 NTNG1 ASIC4 CSMD3 PDZD2	1.73e-07	200	55	6	4fc3de4bff7ed2bf40b38462c4b4e9b87af6a4ca
ToppCell	Macroglial-Polydendrocytes-PDGFRA-\|Macroglial / cells hierarchy compared to all cells using T-Statistic	NELL1 HECW1 NTNG1 ASIC4 CSMD3 PDZD2	1.73e-07	200	55	6	f17b5a54e8f9eba9dcd0808ba4e8d275ac41bce2
ToppCell	Macroglial-Polydendrocytes-PDGFRA--\|Macroglial / cells hierarchy compared to all cells using T-Statistic	NELL1 HECW1 NTNG1 ASIC4 CSMD3 PDZD2	1.73e-07	200	55	6	cc3409518f8b436ea92deb955e81114b3f410ff7
ToppCell	Macroglial-Polydendrocytes-PDGFRA----L1-6\|Macroglial / cells hierarchy compared to all cells using T-Statistic	NELL1 HECW1 NTNG1 ASIC4 CSMD3 PDZD2	1.73e-07	200	55	6	310cd53db1c137f6af74e6ae682221d7ac27310c
ToppCell	Macroglial-Polydendrocytes-PDGFRA\|Macroglial / cells hierarchy compared to all cells using T-Statistic	NELL1 HECW1 NTNG1 ASIC4 CSMD3 PDZD2	1.73e-07	200	55	6	c24a3099e3d96d8b72f6d05286bb355d661a0377
ToppCell	Macroglial-Polydendrocytes\|Macroglial / cells hierarchy compared to all cells using T-Statistic	NELL1 HECW1 NTNG1 ASIC4 CSMD3 PDZD2	1.73e-07	200	55	6	961858738ce35db8760c8c2e136f8369bc444ccf
ToppCell	Frontal_cortex-Neuronal-Inhibitory-iN2(Gad1Gad2)\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	RPP25 CHAT ASIC4 PDE11A SCML4	1.56e-06	159	55	5	7f29f9dcf25ffa1822b137c571e9ac16defc6292
ToppCell	10x3'2.3-week_14-16-Lymphocytic_NK-T_NK-ILC_precursor\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	COL4A4 HECW1 SCN8A PREX1 SCML4	2.87e-06	180	55	5	27672ac6a02172a31851f18decb9acffa8f5a703
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-OPC-OPC-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	FZD9 HECW1 SOX8 CSMD3 PDZD2	4.68e-06	199	55	5	19a97e27a4758e794ce7246d295e112b47931a48
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-OPC\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	FZD9 HECW1 SOX8 CSMD3 PDZD2	4.68e-06	199	55	5	333056c2abe9724efeab542c0365fcfe4eff8f18
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-OPC-OPC\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	FZD9 HECW1 SOX8 CSMD3 PDZD2	4.68e-06	199	55	5	e60ecbb8fa7bcd3e2ce7d78f6efb2cfd1fd77698
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Sncg-Sncg_Vip_Itih5\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	ASIC4 FAM181B PDE11A SCML4	1.21e-05	114	55	4	9f0c8dfd740d50448a6c91a00e7bae4dfc9b3302
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Sncg-Sncg_Vip_Itih5\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	ASIC4 FAM181B PDE11A SCML4	1.29e-05	116	55	4	605bd4fdf547cc41783e99cd78425760ef6461ef
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Sncg-Sncg_Vip_Nptx2\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	ASIC4 FAM181B PDE11A SCML4	1.58e-05	122	55	4	91e338db581b36baffecc323b1909f2069b27242
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Sncg\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	ASIC4 FAM181B PDE11A SCML4	2.21e-05	133	55	4	840e8240db29cd21ed9830843c0fa6d65b8f300a
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Pvalb-Pvalb_Sema3e_Kank4\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	BCL2L11 MYPN ADAMTS8 FAM181B	2.35e-05	135	55	4	54b2aaf8d322e01a3ff6099c2422d68ecccf96b4
ToppCell	Frontal_cortex-Neuronal-Inhibitory-iN2(Gad1Gad2)-Synpr\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	RPP25 CHAT ASIC4 SCML4	2.63e-05	139	55	4	408bc31aa5e1c2b379f79198fe8b5411f8d7bd08
ToppCell	Posterior_cortex-Neuronal-Inhibitory-iN2(Gad1Gad2)-Synpr\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	RPP25 CHAT ASIC4 SCML4	3.02e-05	144	55	4	04f9054895be2275eecda687a6eeb02fa5ec69b9
ToppCell	facs-Lung-Endomucin-24m-Endothelial-Capillary_Type_1_Cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HECW1 MYPN CSMD3 PDE11A	3.11e-05	145	55	4	96712c68ab759d7ade0d912581a1a7c25dc6def8
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Lmo1_Myl1\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	CHAT ASIC4 FAM181B SCML4	3.11e-05	145	55	4	590ba937c741ae67460f303eca88b1cd3ac87f64
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Lmo1_Fam159b\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	CHAT ASIC4 FAM181B SCML4	3.37e-05	148	55	4	9205b26e0d042b342cc643cda0f4f3f8bb392d00
ToppCell	368C-Fibroblasts-Fibroblast-F-\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	COL4A4 LINC02875 SP5 ZNF853	3.45e-05	149	55	4	9286bc56ff2e245630537a0bda5f1a1e17be863a
ToppCell	368C-Fibroblasts-Fibroblast-F\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	COL4A4 LINC02875 SP5 ZNF853	3.45e-05	149	55	4	f53151d9e5e724a61be0ee6a8c740d1990f28d5f
ToppCell	Posterior_cortex-Neuronal-Inhibitory-iN2(Gad1Gad2)\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	RPP25 CHAT ASIC4 PDE11A	4.03e-05	155	55	4	105d59d8a1bb8cb37eef2c1767d737b2108ac7c5
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Rspo4_Rxfp1_Chat\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	RPP25 CHAT ASIC4 CSMD3	4.03e-05	155	55	4	3b8def9e8f66511736ea37f259511f7c8b7743af
ToppCell	368C-Fibroblasts-Fibroblast-F-\|368C / Donor, Lineage, Cell class and subclass (all cells)	COL4A4 LINC02875 SP5 ZNF853	4.24e-05	157	55	4	982e6ea78c7dabdb7c07c4a5fb2425d5e45b5b94
ToppCell	368C-Fibroblasts-Fibroblast-F\|368C / Donor, Lineage, Cell class and subclass (all cells)	COL4A4 LINC02875 SP5 ZNF853	4.24e-05	157	55	4	74038192f016f95f80e0189035ee8ccc22ceb1b8
ToppCell	facs-Lung-24m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_type_1_endothelial_cell\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	HECW1 MYPN CSMD3 PDE11A	4.79e-05	162	55	4	bf886e22ff2a20353499004b53f25fb9e6574896
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Mesenchymal-fibroblastic-Stromal_2_(NPY+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	NELL1 NFKB1 SAMD14 CSMD3	5.26e-05	166	55	4	3b67064a5149e72f895344d938c64b8ff65247f5
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1-3_VIP_SSTR1\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	COL4A4 ASIC4 PDE11A SCML4	5.77e-05	170	55	4	667443062882642211ad116043775ef8eda38859
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Vip\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	RPP25 CHAT ASIC4 CSMD3	5.91e-05	171	55	4	5efd15300f865ebf651e0888265cbd717bc3b9d3
ToppCell	facs-Heart-LV-3m-Endothelial-endothelial_cell_of_endocardium\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL4A4 SP5 MAML3 PGM5	6.04e-05	172	55	4	f2c17c49b375b28ad47dc6cabda62f1c238023dd
ToppCell	facs-Heart-LV-3m-Endothelial-endocardial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL4A4 SP5 MAML3 PGM5	6.04e-05	172	55	4	6ab4f01098dddb789df298ddf97b3c384405ee6c
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Vip\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	RPP25 CHAT ASIC4 CSMD3	6.04e-05	172	55	4	7e1a7700a4c2b1d100da1d6e475e73498ebb605a
ToppCell	wk_20-22-Hematologic_Lymphocytic-T_&_ILC-ILCP\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	COL4A4 PREX1 PDZD2 SCML4	6.32e-05	174	55	4	5e6050d20a5b27640f6a200441125b8ceba123c8
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Chat_Htr1f\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	RPP25 CHAT ASIC4 CSMD3	6.32e-05	174	55	4	a5f2a4e3b25e6084bd7003a53da86a44f6fcf294
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex-lymphatic_endothelial_cell_of_renal_cortex\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	C2CD4B MYPN SOX8 PGM5	6.46e-05	175	55	4	9a96a946db731ba24c9be34bedebf1f4a1372b9e
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Endothelial-lymphatic_endothelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	C2CD4B MYPN SOX8 PGM5	6.46e-05	175	55	4	54c1f080195ad8392a095e83b56a4b54073d4c0d
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	C2CD4B MYPN SOX8 PGM5	6.46e-05	175	55	4	2b51406a2c2daa13ab4ed283ede038cd11d9e641
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Ptprt_Pkp2\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	CHAT ASIC4 FAM181B CSMD3	6.60e-05	176	55	4	05ec715439f2eb1696f5d8855da0dd1dd70effd0
ToppCell	facs-Trachea-18m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l32-30\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	BRSK2 BRME1 NTNG1 SHROOM2	6.75e-05	177	55	4	59cf56c385c324f0844f20003d2b5049a2791e45
ToppCell	Control-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	NELL1 SH3RF1 NTNG1 PGM5	7.21e-05	180	55	4	08ae0f5d95c45feba68ad99788f7af7ff4c979af
ToppCell	Control-Stromal_mesenchymal-Matrix_Fibroblast\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	NELL1 SH3RF1 NTNG1 PGM5	7.21e-05	180	55	4	9b1de1b4711adbf9a423f4d2d08f3f4c78f1f8f4
ToppCell	Control-Stromal_mesenchymal-Matrix_Fibroblast-Diff_MatrixFB\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	NELL1 SH3RF1 NTNG1 PGM5	7.36e-05	181	55	4	9e7d0f1afb8d9bc5a209ddb5314df3a25a0274d9
ToppCell	Primary_Motor_Cortex_(M1)-Non-neuronal-Macroglial-Oligo-OPC\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	NTNG1 ASIC4 SOX8 PDZD2	7.52e-05	182	55	4	831b5ce46b41efe01c4db6016c2f43148611373d
ToppCell	wk_15-18-Hematologic_Lymphocytic-T_&_ILC-ILCP\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	COL4A4 NFKB1 PREX1 SCML4	7.52e-05	182	55	4	6bd48c5d60a259719f65cacee4b8135247e78fa9
ToppCell	Primary_Motor_Cortex_(M1)-Non-neuronal-Macroglial-Oligo-OPC-OPC_L1-6_MYT1\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	NTNG1 ASIC4 SOX8 PDZD2	7.52e-05	182	55	4	a05e5978ef5f7fac7eeb2ba1c0103ea90d5e9136
ToppCell	5'-GW_trimst-2-LymphNode-Hematopoietic-T_cells-ILCP\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	COL4A4 PREX1 PDZD2 SCML4	7.68e-05	183	55	4	4a1e5bf58d2acd9dbceeef538b6851c1e5e91059
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1-6_LAMP5_CA13_(Lamp5_Lhx6_1)\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	COL4A4 NTNG1 GOLGA8K SSPOP	7.85e-05	184	55	4	ae0a77e3e520a246b17776bb19503519636b02ee
ToppCell	PCW_13-14-Neuronal\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	BRSK2 CHAT SOX8 FAM181B	7.85e-05	184	55	4	65cf3460125e3dbc34978957bc138a449f71f7df
ToppCell	PCW_07-8.5-Neuronal-Neuronal_SCP\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	BRSK2 SOX8 FAM181B PREX1	8.01e-05	185	55	4	56c7a0dbf141728ac76b8c90af197719942ca67c
ToppCell	facs-Heart-LA-18m-Mesenchymal-valve_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SH3RF1 ARVCF ASIC4 PDZD2	8.18e-05	186	55	4	e2ba9f3518d87a44537a57a648df17ab98fbbb39
ToppCell	droplet-Liver-Hepatocytes-24m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL4A4 SH3RF1 ARVCF PGM5	8.18e-05	186	55	4	90d53c2597a9f3a2b39afba75adfc54f1ca0a4db
ToppCell	facs-Heart-LA-18m-Mesenchymal-valve_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SH3RF1 ARVCF ASIC4 PDZD2	8.18e-05	186	55	4	fda3415222f688ef5cd8de4b0b79daa2493c585f
ToppCell	droplet-Liver-Hepatocytes-24m-Endothelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL4A4 SH3RF1 ARVCF PGM5	8.18e-05	186	55	4	2cae34336f184f971f7c8684cc27c23a4e7369ed
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_chondroblast_(18)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	FZD9 FGFRL1 SOX8 PDZD2	9.06e-05	191	55	4	f9a46956778a8773d6656340ecf5d218376d79c2
ToppCell	Control-Myeloid-TRAM2\|Myeloid / Condition, Lineage and Cell class	NFKB1 NFKB2 SCN8A PDZD2	9.25e-05	192	55	4	571fd71dad361a8b6c1bf9ad7184a89b3fbec667
ToppCell	renal_cortex_nuclei\|World / Celltypes from Cells and Nuclei per compartment and clinical group	SH3RF1 TNRC6B BABAM2 PDZD2	9.25e-05	192	55	4	e8cc4d08fcfceeab75a02558817e4ccd7dbafe3a
ToppCell	LPS-IL1RA-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	NELL1 NTNG1 ADAMTS8 PGM5	9.25e-05	192	55	4	deeecd26972241846b4cb998edf0c7a87ff0c4df
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_B-B_cell-B_c02-MS4A1-CD27\|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)	ASXL1 BCL2L11 NFKB1 NFKB2	9.43e-05	193	55	4	bbea475d2c4c7b29674ff302529f8f83dd666dcb
ToppCell	18-Distal-Mesenchymal-Cartilage\|Distal / Age, Tissue, Lineage and Cell class	FZD9 FGFRL1 OAT SOX8	9.43e-05	193	55	4	52f3d1bb8d8ca91ba12439d46392f377928ff8f8
ToppCell	Control-Myeloid-TRAM2\|Control / Condition, Lineage and Cell class	NFKB1 NFKB2 SCN8A PDZD2	9.62e-05	194	55	4	d951dd1274d3ff1ac30671ec4153a4a8bc97b53f
ToppCell	facs-Skin-Telogen-3m-Epithelial-bulge_keratinocyte\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SH3RF1 ARVCF CHAT MN1	1.00e-04	196	55	4	90edf61116ffcb4f8b6be3d0a05732d59b0a87d5
ToppCell	facs-Skin-Telogen-3m-Epithelial-outer_bulge\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SH3RF1 ARVCF CHAT MN1	1.00e-04	196	55	4	c936014125b2ed5f796221b74acb77b8f8359875
ToppCell	Bronchus_Control_(B.)-Endothelial-TX\|Bronchus_Control_(B.) / Sample group, Lineage and Cell type	FZD9 NELL1 BRSK2 PDE11A	1.04e-04	198	55	4	feac39036b5c0ab97b524cc366286942d136d42f
ToppCell	Bronchus_Control_(B.)-Endothelial-TX-Bronchial_vessel\|Bronchus_Control_(B.) / Sample group, Lineage and Cell type	FZD9 NELL1 BRSK2 PDE11A	1.04e-04	198	55	4	dcf334d13e5b0018fee24febccfef91c9e17843b
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW12-OPC_related-OPC\|GW12 / Sample Type, Dataset, Time_group, and Cell type.	ADAMTS8 ASIC4 SOX8 FAM181B	1.06e-04	199	55	4	c0dc14fb9899d4263264347436de121814441dfb
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW12-OPC_related\|GW12 / Sample Type, Dataset, Time_group, and Cell type.	ADAMTS8 ASIC4 SOX8 FAM181B	1.06e-04	199	55	4	9bc53ff93ca97af4ee0f01c74a567987a26abb18
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-OPC-OPC-F\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	FZD9 SOX8 CSMD3 PDZD2	1.08e-04	200	55	4	ad777683adeb2ce45ade570386235e311fa7ea2d
ToppCell	Substantia_nigra-Neuronal-Excitatory-eN1(Slc17a7)-eN1_1-Excitatory_Neuron.Slc17a7.C1ql3_(Hippocampus_Excitatory_Neuron)-\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	C2CD4B BRME1 ADAMTS13	2.35e-04	97	55	3	1da964954a95c497ac4a24df1ea3575df5747025
ToppCell	Substantia_nigra-Neuronal-Excitatory-eN1(Slc17a7)\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	C2CD4B BRME1 ADAMTS13	2.35e-04	97	55	3	dd188763ba02337e4f25d56766eda886cffa810d
ToppCell	Substantia_nigra-Neuronal-Excitatory-eN1(Slc17a7)-eN1_1\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	C2CD4B BRME1 ADAMTS13	2.35e-04	97	55	3	a0242258aad0766450ff52fe28278cbb2b8d63a0
ToppCell	Substantia_nigra-Neuronal-Excitatory-eN1(Slc17a7)-eN1_1-Excitatory_Neuron.Slc17a7.C1ql3_(Hippocampus_Excitatory_Neuron)\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	C2CD4B BRME1 ADAMTS13	2.35e-04	97	55	3	98a31b9bf0adcad1cb1d803bf7a23d49b4e1f2d5
ToppCell	Entopeduncular-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Otx2_(ventral_lateral_geniculate_nucleus,_magnocellular_part_(VLGMC)?)--\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	COL4A4 ASIC4 SCML4	2.97e-04	105	55	3	c7528276fee8f6d2cb4639069bc87413b0288025
ToppCell	Entopeduncular-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Otx2_(ventral_lateral_geniculate_nucleus,_magnocellular_part_(VLGMC)?)\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	COL4A4 ASIC4 SCML4	2.97e-04	105	55	3	7bcf3345a21a1ade717128be127e9fe12ae40011
ToppCell	Entopeduncular-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Otx2_(ventral_lateral_geniculate_nucleus,_magnocellular_part_(VLGMC)?)-\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	COL4A4 ASIC4 SCML4	2.97e-04	105	55	3	62e89b92bb8c5187ab0205aebd018b4178710bb0
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Rxfp1_Prdm8\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	HUS1B NTNG1 FAM181B	4.49e-04	121	55	3	2ae870f822488799cd0ad85e7f72af64e33a867f
ToppCell	Control-Stromal_mesenchymal-Matrix_Fibroblast-Activated_MatrixFB\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	NELL1 NTNG1 CHAT	4.94e-04	125	55	3	b162a5bfbb8ac5e65e13578fef9de442a9e4fd8b
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Igfbp6_Car10\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	RPP25 ASIC4 CSMD3	5.18e-04	127	55	3	f808c727c0817ed10e76eaffa9493a516e9a6b50
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Serpinf1-Serpinf1_Aqp5_Vip\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	COL4A4 ASIC4 PDE11A	6.32e-04	136	55	3	8f5682422ba0b477c1e0700212948457f106cb10
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Igfbp4_Mab21l1\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	RPP25 ASIC4 CSMD3	6.32e-04	136	55	3	9cf076597e6fd9390850fda259daa13022f15893
ToppCell	facs-Marrow-B-cells-3m-Myeloid-granulocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SCN8A NTNG1 SSPOP	6.45e-04	137	55	3	4dcb15de821439011df1bb0bbd7682d674bd725d
ToppCell	facs-Marrow-B-cells-3m-Myeloid-granulocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SCN8A NTNG1 SSPOP	6.45e-04	137	55	3	c05ceeb7b483324604cb3f647d2da2b3786071b1
ToppCell	COVID-19-kidney-Technical/muscle_(PCT)\|COVID-19 / Disease (COVID-19 only), tissue and cell type	NELL1 HECW1 CSMD3	6.73e-04	139	55	3	a1945b07f177cde40e7eea03a19236ce76165857
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Igfbp6_Pltp\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	RPP25 NELL1 ASIC4	6.73e-04	139	55	3	9e9f29f92dbe65b26cc78b3a1c00778c6a701f5b
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Pvalb-Pvalb_Vipr2\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	BCL2L11 ADAMTS8 PDE11A	6.87e-04	140	55	3	72c272f44e5600b3037c1dbf9d3a4669a35588d8
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Pvalb-Pvalb_Gabrg1\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	NELL1 MYPN FAM181B	6.87e-04	140	55	3	2c44e8cc5190226049be7ebc465d685393e701c4
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Sncg\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	FAM181B PDE11A SCML4	7.16e-04	142	55	3	ed91d2ef4c346f7e1a5402846e2a34cee19c24d1
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Lmo1_Myl1\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	CHAT ASIC4 FAM181B	7.46e-04	144	55	3	0322fef818a963be00535d5f141f028d43de5c6a
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Chrna2_Ptgdr\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	RPP25 NELL1 SAMD14	7.46e-04	144	55	3	71107275767a0728541a3695715c44874b3e5efc
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Pvalb-Pvalb_Reln_Itm2a\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	BCL2L11 MYPN ADAMTS8	7.46e-04	144	55	3	0bbe670454846cf9bc7464ae4e91488415c4111d
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Rspo1_Itga4\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	RPP25 ASIC4 CSMD3	7.46e-04	144	55	3	7de962346ba9653d90dd13bb7d977fe44d200bba
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Mesenchymal-fibroblastic-Stromal_2_(NPY+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	NELL1 OCA2 ADAMTS13	8.23e-04	149	55	3	aedbae2dffa1e880e5c6a146b6d5a135e7f54308
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Lmo1_Fam159b\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	ASIC4 FAM181B SCML4	8.23e-04	149	55	3	98ae408d2d0347865875ff8bbd89d359decea526
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Lamp5-Lamp5_Ntn1_Npy2r\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	RPP25 COL4A4 ASIC4	8.72e-04	152	55	3	8ff5a178a8f3550d89a003c0858820aab3773386
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Arhgap36_Hmcn1\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	ASIC4 FAM181B CSMD3	8.89e-04	153	55	3	9c6fce56300ba5053efda59a438d63a808c497c0
ToppCell	facs-Large_Intestine-Distal-3m-Epithelial-Brush_cell_of_epithelium_proper_of_large_intestine\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CHAT SAMD14 MN1	8.89e-04	153	55	3	3b1b0cc8e9dd2b1484649789330713282ee44414
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Rspo1_Itga4\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	RPP25 ASIC4 CSMD3	9.23e-04	155	55	3	cba6f3f7742b4d5d54ad0a0ac0dd4016e73fe658
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Lect1_Oxtr\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	RPP25 ASIC4 CSMD3	9.23e-04	155	55	3	99e749f7075e2c64e9a0bf91009f95b6969197c8
ToppCell	10x5'-bone_marrow-Lymphocytic_Invariant-Inducer-like-ILC3\|bone_marrow / Manually curated celltypes from each tissue	COL4A4 HUS1B ADAMTS13	9.23e-04	155	55	3	83430a64c2cb5ad29caa3dacba76c28dd204ac40
Disease	MYELODYSPLASTIC SYNDROME	ASXL1 SF3B1	2.92e-05	5	51	2	614286
Disease	Myelodysplastic syndrome	ASXL1 SF3B1	2.92e-05	5	51	2	cv:C3463824
Disease	HIRSCHSPRUNG DISEASE, SUSCEPTIBILITY TO, 1	ARVCF MED12	4.37e-05	6	51	2	C3888239
Disease	body weight	NELL1 SH3RF1 BCL2L11 LINC02875 NTNG1 TNRC6B OCA2 MAML3 ABHD17C PDZD2	5.06e-05	1261	51	10	EFO_0004338
Disease	opportunistic bacterial infectious disease (implicated_via_orthology)	NFKB1 NFKB2	1.05e-04	9	51	2	DOID:0050340 (implicated_via_orthology)
Disease	Immunoglobulin Deficiency, Late-Onset	NFKB1 NFKB2	1.59e-04	11	51	2	C2936665
Disease	Acquired Hypogammaglobulinemia	NFKB1 NFKB2	1.59e-04	11	51	2	C2936664
Disease	Common variable immunodeficiency	NFKB1 NFKB2	2.26e-04	13	51	2	cv:C0009447
Disease	testosterone measurement	FZD9 ZNF703 BCL2L11 NFKB1 MYPN NTNG1 FGFRL1 CSMD3 MED12	3.02e-04	1275	51	9	EFO_0004908
Disease	myelodysplastic syndrome (implicated_via_orthology)	ASXL1 SF3B1	3.03e-04	15	51	2	DOID:0050908 (implicated_via_orthology)
Disease	Common Variable Immunodeficiency	NFKB1 NFKB2	3.03e-04	15	51	2	C0009447
Disease	Alzheimer disease, age at onset	COL4A4 SH3RF1 ARVCF CSMD3 SCML4	3.12e-04	343	51	5	EFO_0004847, MONDO_0004975
Disease	reticulocyte count	NELL1 BCL2L11 DCAF10 NFKB1 TNRC6B FGFRL1 MED12 PDZD2	3.97e-04	1045	51	8	EFO_0007986
Disease	Craniosynostosis	NELL1 MN1	5.46e-04	20	51	2	C0010278
Disease	maximal midexpiratory flow rate	TUBGCP6 OCA2	5.46e-04	20	51	2	EFO_0004313
Disease	Neurodevelopmental Disorders	SCN8A BRSK2 TNRC6B	5.66e-04	93	51	3	C1535926
Disease	cortical thickness	FZD9 NELL1 SF3B1 NFKB1 TNRC6B FGFRL1 ADAMTS8 PDZD2	6.02e-04	1113	51	8	EFO_0004840
Disease	cup-to-disc ratio measurement	MYPN ADAMTS8 BABAM2 MN1 PDZD2	8.69e-04	430	51	5	EFO_0006939
Disease	unipolar depression, depressive symptom measurement	PREX1 MAML3	9.27e-04	26	51	2	EFO_0003761, EFO_0007006
Disease	waist-hip ratio	NELL1 C2CD4B BCL2L11 LINC02875 TNRC6B MN1 MAML3 ABHD17C	1.13e-03	1226	51	8	EFO_0004343
Disease	Hematopoetic Myelodysplasia	ASXL1 SF3B1	1.15e-03	29	51	2	C2713368
Disease	chronic obstructive pulmonary disease	FZD9 BCL2L11 MYPN MN1 MAML3 PDZD2	1.16e-03	688	51	6	EFO_0000341
Disease	myelodysplastic syndrome (is_implicated_in)	ASXL1 SF3B1	1.24e-03	30	51	2	DOID:0050908 (is_implicated_in)
Disease	creatinine measurement	NELL1 LINC02875 NFKB1 MYPN TNRC6B ASIC4 BABAM2	1.54e-03	995	51	7	EFO_0004518

Protein segments in the cluster

Peptide	Gene	Start	Entry
GPGDGCFTLPGHREA	ARVCF	221	O00192
PHCSGDATGTCGDPG	CSMD3	3046	Q7Z407
DATGTCGDPGTPGHG	CSMD3	3051	Q7Z407
PRGPHGGAASGLNGC	CTAG1A	61	P78358
ADGTPCGPGHLCSEG	ADAMTS8	496	Q9UP79
GSPGCPGHFGASGEQ	COL4A4	1091	P53420
GNHGGEGDSCPHGSP	BCL2L11	46	O43521
GDGGEACGHPEPRGG	ASXL1	666	Q8IXJ9
GLEHDGAPGSGCGPS	ADAMTS13	231	Q76LX8
AAAAAGCEGGGGPNP	MTMR1	6	Q13613
GAGGADPSHSCPRGA	OCA2	41	Q04671
ASHCPGGPGGEFGVK	PGM5	121	Q15124
SGGNLPGVHCGPSSG	LRCH3	21	Q96II8
SNHPAAGGCGGSGGP	MAML3	46	Q96JK9
EGATPGTAHPGHSGG	HECW1	621	Q76N89
SAHGPLGDSAAAGPG	BRSK2	696	Q8IWQ3
RAHSCGGGGGPDAPL	C2CD4B	126	A6NLJ0
GPGVGLCEEHGSPAA	FGFRL1	441	Q8N441
SAHSQPLPGGGDCGG	PDE11A	81	Q9HCR9
AQGHPPAGAGGGSSC	PDZD2	1456	O15018
PHSPGGDGSAGAGAE	DCAF10	6	Q5QP82
GSGGCGSTIGPLPHD	MED12	211	Q93074
SPGPEHPEGGQGCDS	TUBGCP6	831	Q96RT7
HTLDSLGGGPEGPCF	ASIC4	356	Q96FT7
GGCGPSGPDVSLGDL	FAM181B	241	A6NEQ2
SGPSCSGDCPHEGGL	NELL1	626	Q92832
LGPGAGGSGTCENPE	FZD9	186	O00144
EPGGCAKDAALGGGH	GOLGA8K	496	D6RF30
GAGDSGHASPDTGPC	BRME1	431	Q0VDD7
GSSALHIPAFPGGGC	BABAM2	231	Q9NXR7
GHPPGSAFGVEAGCR	LINC02875	86	Q86X59
PEEGAGAGPGACSLH	ABHD17C	76	Q6PCB6
HEQDAGGPGGAAGSP	MAP3K12	51	Q12852
PDSLCFGPAGSGGLH	HUS1B	36	Q8NHY5
GNFGGPDPGASCLHG	MN1	116	Q10571
EAPAGCGAEGGGPGS	RPP25	11	Q9BUL9
GSCGSDSGQGAPPHG	NTNG1	506	Q9Y2I2
GSGLSGACAGAPHAP	SP5	206	Q6BEB4
PQHGGAPCTGEAGEA	SSPOP	3441	A2VEC9
GSEPGGDGAGDCAHP	PREX1	6	Q8TCU6
GSGGPGCPQEAHADG	SHROOM2	381	Q13796
GPGGKVTDGCGSPLH	SAMD14	66	Q8IZD0
SDSGAELGPHPGGGA	SOX8	186	P57073
PGEHGSTYGGNPLGC	OAT	316	P04181
GHGRAGSCPVDGDGP	SH3RF1	766	Q7Z6J0
GDVGGPAGNPGCSPH	CHAT	46	P28329
PHHSDCKNGGGVGGG	ZNF703	226	Q9H7S9
CSGGHAPSGFPALGL	nan	31	P0C879
GDTPGHATPGHGGAT	SF3B1	271	O75533
EHPGSGFKGDCGNPS	SCN8A	1726	Q9UQD0
CLEDGGPGPDTLSGG	ZNF853	31	P0CG23
DSHLGGGPAATAGGP	SCML4	276	Q8N228
PGDTLGGHTGPAGDS	TNRC6B	1441	Q9UPQ9
PGGSAKDAAPGGGHH	GOLGA8CP	461	A6NN73
PCHFGSPSGAAEGGG	MYPN	41	Q86TC9
CEGPSHGGLPGASSE	NFKB1	61	P19838
GCEGPSHGGLPGASS	NFKB2	56	Q00653