Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	positive regulation of smooth muscle cell differentiation	MYOCD NOTCH2 NOTCH4	3.49e-05	28	47	3	GO:0051152
GeneOntologyBiologicalProcess	regulation of cell growth by extracellular stimulus	PPAN MYOCD	5.06e-05	5	47	2	GO:0001560
Domain	NOD	NOTCH2 NOTCH4	4.03e-05	4	49	2	PF06816
Domain	Notch	NOTCH2 NOTCH4	4.03e-05	4	49	2	IPR008297
Domain	NODP	NOTCH2 NOTCH4	4.03e-05	4	49	2	PF07684
Domain	Notch_NODP_dom	NOTCH2 NOTCH4	4.03e-05	4	49	2	IPR011656
Domain	Notch_NOD_dom	NOTCH2 NOTCH4	4.03e-05	4	49	2	IPR010660
Domain	NOD	NOTCH2 NOTCH4	4.03e-05	4	49	2	SM01338
Domain	NODP	NOTCH2 NOTCH4	4.03e-05	4	49	2	SM01339
Domain	hEGF	FAT4 NOTCH2 NOTCH4	5.31e-05	28	49	3	PF12661
Domain	LNR	NOTCH2 NOTCH4	6.71e-05	5	49	2	PS50258
Domain	EGF_CA	FAT4 FAT3 NOTCH2 NOTCH4	7.58e-05	86	49	4	PF07645
Domain	EGF_Ca-bd_CS	FAT4 FAT3 NOTCH2 NOTCH4	1.21e-04	97	49	4	IPR018097
Domain	EGF_CA	FAT4 FAT3 NOTCH2 NOTCH4	1.31e-04	99	49	4	PS01187
Domain	ASX_HYDROXYL	FAT4 FAT3 NOTCH2 NOTCH4	1.36e-04	100	49	4	PS00010
Domain	Notch_dom	NOTCH2 NOTCH4	1.40e-04	7	49	2	IPR000800
Domain	Notch	NOTCH2 NOTCH4	1.40e-04	7	49	2	PF00066
Domain	NL	NOTCH2 NOTCH4	1.40e-04	7	49	2	SM00004
Domain	EGF-type_Asp/Asn_hydroxyl_site	FAT4 FAT3 NOTCH2 NOTCH4	1.71e-04	106	49	4	IPR000152
Domain	EGF_CA	FAT4 FAT3 NOTCH2 NOTCH4	2.93e-04	122	49	4	SM00179
Domain	EGF-like_Ca-bd_dom	FAT4 FAT3 NOTCH2 NOTCH4	3.11e-04	124	49	4	IPR001881
Domain	RRM_1	PTBP3 RBMS1 NOL8 HNRNPR	2.14e-03	208	49	4	PF00076
Domain	RRM	PTBP3 RBMS1 NOL8 HNRNPR	2.49e-03	217	49	4	SM00360
Domain	RRM_dom	PTBP3 RBMS1 NOL8 HNRNPR	2.93e-03	227	49	4	IPR000504
Domain	RRM	PTBP3 RBMS1 NOL8 HNRNPR	3.08e-03	230	49	4	PS50102
Domain	EGF_3	FAT4 FAT3 NOTCH2 NOTCH4	3.32e-03	235	49	4	PS50026
Domain	EGF	FAT4 FAT3 NOTCH2 NOTCH4	3.32e-03	235	49	4	SM00181
Domain	-	PTBP3 RBMS1 NOL8 HNRNPR	3.80e-03	244	49	4	3.30.70.330
Domain	EGF-like_dom	FAT4 FAT3 NOTCH2 NOTCH4	4.08e-03	249	49	4	IPR000742
Domain	EGF_1	FAT4 FAT3 NOTCH2 NOTCH4	4.44e-03	255	49	4	PS00022
Domain	LAM_G_DOMAIN	FAT4 FAT3	4.46e-03	38	49	2	PS50025
Domain	Nucleotide-bd_a/b_plait	PTBP3 RBMS1 NOL8 HNRNPR	4.63e-03	258	49	4	IPR012677
Domain	EGF-like_CS	FAT4 FAT3 NOTCH2 NOTCH4	4.82e-03	261	49	4	IPR013032
Domain	Laminin_G_2	FAT4 FAT3	4.94e-03	40	49	2	PF02210
Domain	EGF_2	FAT4 FAT3 NOTCH2 NOTCH4	5.09e-03	265	49	4	PS01186
Domain	LamG	FAT4 FAT3	5.95e-03	44	49	2	SM00282
Domain	Growth_fac_rcpt_	FAT4 NOTCH2 NOTCH4	7.95e-03	156	49	3	IPR009030
Domain	-	ZNF438 ZNF605 ZNF41 PRDM5 ZNF568 ZNF248	8.36e-03	679	49	6	3.30.160.60
Domain	zf-C2H2	ZNF438 ZNF605 ZNF41 PRDM5 ZNF568 ZNF248	9.19e-03	693	49	6	PF00096
Domain	Znf_C2H2/integrase_DNA-bd	ZNF438 ZNF605 ZNF41 PRDM5 ZNF568 ZNF248	9.26e-03	694	49	6	IPR013087
Domain	Laminin_G	FAT4 FAT3	1.02e-02	58	49	2	IPR001791
Pathway	REACTOME_DEFECTIVE_LFNG_CAUSES_SCDO3	NOTCH2 NOTCH4	7.04e-05	5	38	2	M27411
Pathway	REACTOME_PRE_NOTCH_PROCESSING_IN_THE_ENDOPLASMIC_RETICULUM	NOTCH2 NOTCH4	1.05e-04	6	38	2	M27068
Pathway	KEGG_MEDICUS_REFERENCE_NOTCH_PROTEOLYTIC_ACTIVATION	NOTCH2 NOTCH4	3.83e-04	11	38	2	M47865
Pathway	KEGG_MEDICUS_PATHOGEN_HPV_E6_TO_NOTCH_SIGNALING_PATHWAY_N00380	NOTCH2 NOTCH4	4.59e-04	12	38	2	M47532
Pathway	KEGG_MEDICUS_PATHOGEN_HPV_E6_TO_NOTCH_SIGNALING_PATHWAY_N00381	NOTCH2 NOTCH4	4.59e-04	12	38	2	M47533
Pathway	KEGG_MEDICUS_REFERENCE_NOTCH_SIGNALING_PATHWAY	NOTCH2 NOTCH4	5.42e-04	13	38	2	M47423
Pathway	KEGG_MEDICUS_PATHOGEN_HPV_E6_TO_NOTCH_SIGNALING_PATHWAY_N00382	NOTCH2 NOTCH4	5.42e-04	13	38	2	M47534
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	VAPB CASP8AP2 AIMP2 BRCA1 RAE1 DCLRE1A HADHA CDC73 GNL3 RFWD3 PPP1CA NOL8 HNRNPR	3.15e-08	1294	51	13	30804502
Pubmed	Comprehensive Interactome Mapping of the DNA Repair Scaffold SLX4 Using Proximity Labeling and Affinity Purification.	ERCC6 BRCA1 DCLRE1A CDC73 MCM10 NOL8	8.96e-07	222	51	6	37071664
Pubmed	A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.	PTBP3 BRCA1 RBMS1 DCLRE1A HADHA LACTB PPP1CA NOL8 HNRNPR	9.73e-07	724	51	9	36232890
Pubmed	Notch receptors and hematopoiesis.	NOTCH2 NOTCH4	2.11e-06	2	51	2	11532344
Pubmed	CSB interacts with SNM1A and promotes DNA interstrand crosslink processing.	ERCC6 DCLRE1A	2.11e-06	2	51	2	25505141
Pubmed	The K898E germline variant in the PP1-binding motif of BRCA1 causes defects in DNA Repair.	BRCA1 PPP1CA	2.11e-06	2	51	2	25056273
Pubmed	notch2, notch4 gene polymorphisms in psoriasis vulgaris.	NOTCH2 NOTCH4	2.11e-06	2	51	2	23587900
Pubmed	Inflammation dysregulates Notch signaling in endothelial cells: implication of Notch2 and Notch4 to endothelial dysfunction.	NOTCH2 NOTCH4	2.11e-06	2	51	2	20643108
Pubmed	WWP2 ubiquitylates RNA polymerase II for DNA-PK-dependent transcription arrest and repair at DNA breaks.	ASNSD1 PPAN AIMP2 HADHA GNL3 LACTB PPP1CA HNRNPR	2.98e-06	615	51	8	31048545
Pubmed	Cockayne syndrome group B protein regulates fork restart, fork progression and MRE11-dependent fork degradation in BRCA1/2-deficient cells.	ERCC6 BRCA1	6.32e-06	3	51	2	34871413
Pubmed	LACTB suppresses melanoma progression by attenuating PP1A and YAP interaction.	LACTB PPP1CA	6.32e-06	3	51	2	33675985
Pubmed	Differential expression of Notch genes in human osteoblastic cells.	NOTCH2 NOTCH4	6.32e-06	3	51	2	11836628
Pubmed	Differential Regulation of NOTCH2 and NOTCH3 Contribute to Their Unique Functions in Vascular Smooth Muscle Cells.	MYOCD NOTCH2	6.32e-06	3	51	2	25957400
Pubmed	Integrity of intracellular domain of Notch ligand is indispensable for cleavage required for release of the Notch2 intracellular domain.	NOTCH2 NOTCH4	6.32e-06	3	51	2	11823422
Pubmed	Notch signaling: cell fate control and signal integration in development.	NOTCH2 NOTCH4	6.32e-06	3	51	2	10221902
Pubmed	Regulation of BRCA1 phosphorylation by interaction with protein phosphatase 1alpha.	BRCA1 PPP1CA	6.32e-06	3	51	2	12438214
Pubmed	BRCA1 contributes to transcription-coupled repair of DNA damage through polyubiquitination and degradation of Cockayne syndrome B protein.	ERCC6 BRCA1	6.32e-06	3	51	2	21756275
Pubmed	Host E3 ligase HUWE1 attenuates the proapoptotic activity of the MERS-CoV accessory protein ORF3 by promoting its ubiquitin-dependent degradation.	VAPB PTBP3 RAE1 HADHA CDC73 ACBD3 HNRNPR	1.25e-05	534	51	7	35032548
Pubmed	Prognostic roles of mRNA expression of notch receptors in non-small cell lung cancer.	NOTCH2 NOTCH4	1.26e-05	4	51	2	28061457
Pubmed	The 4 Notch receptors play distinct and antagonistic roles in the proliferation and hepatocytic differentiation of liver progenitors.	NOTCH2 NOTCH4	1.26e-05	4	51	2	24145721
Pubmed	A switch in Notch gene expression parallels stem cell to endothelial transition in infantile hemangioma.	NOTCH2 NOTCH4	1.26e-05	4	51	2	20069356
Pubmed	Expression and clinical significance of Notch receptors in human renal cell carcinoma.	NOTCH2 NOTCH4	1.26e-05	4	51	2	19404845
Pubmed	Notch signaling pathway regulates the growth and the expression of inflammatory cytokines in mouse basophils.	NOTCH2 NOTCH4	1.26e-05	4	51	2	28669409
Pubmed	Evolutionary analysis of vertebrate Notch genes.	NOTCH2 NOTCH4	1.26e-05	4	51	2	11466531
Pubmed	Abnormal expression pattern of Notch receptors, ligands, and downstream effectors in the dorsolateral prefrontal cortex and amygdala of suicidal victims.	NOTCH2 NOTCH4	1.26e-05	4	51	2	24151014
Pubmed	Characterization and developmental expression of the amphioxus homolog of Notch (AmphiNotch): evolutionary conservation of multiple expression domains in amphioxus and vertebrates.	NOTCH2 NOTCH4	1.26e-05	4	51	2	11401408
Pubmed	Notch as a mediator of cell fate determination in hematopoiesis: evidence and speculation.	NOTCH2 NOTCH4	1.26e-05	4	51	2	10194420
Pubmed	Functional conservation of mouse Notch receptor family members.	NOTCH2 NOTCH4	1.26e-05	4	51	2	8898100
Pubmed	Conservation of the biochemical mechanisms of signal transduction among mammalian Notch family members.	NOTCH2 NOTCH4	1.26e-05	4	51	2	11459941
Pubmed	Mutational analysis of NOTCH1, 2, 3 and 4 genes in common solid cancers and acute leukemias.	NOTCH2 NOTCH4	1.26e-05	4	51	2	18184405
Pubmed	Notch signaling in the mammalian central nervous system: insights from mouse mutants.	NOTCH2 NOTCH4	1.26e-05	4	51	2	15917835
Pubmed	Notch pathway activity identifies cells with cancer stem cell-like properties and correlates with worse survival in lung adenocarcinoma.	NOTCH2 NOTCH4	1.26e-05	4	51	2	23444212
Pubmed	Deregulated expression of Notch receptors in human hepatocellular carcinoma.	NOTCH2 NOTCH4	1.26e-05	4	51	2	17920003
Pubmed	The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.	PPAN ERCC6 AIMP2 CDC73 MCM10 GNL3 NOL8 HNRNPR	1.38e-05	759	51	8	35915203
Pubmed	Ubiquitin-Independent Disassembly by a p97 AAA-ATPase Complex Drives PP1 Holoenzyme Formation.	ASNSD1 BRCA1 RAE1 CDC73 GNL3 PPP1CA	1.46e-05	361	51	6	30344098
Pubmed	Expression patterns of Notch receptors and their ligands Jagged and Delta in human placenta.	NOTCH2 NOTCH4	2.10e-05	5	51	2	21726900
Pubmed	Notch and MAML-1 complexation do not detectably alter the DNA binding specificity of the transcription factor CSL.	NOTCH2 NOTCH4	2.10e-05	5	51	2	21124806
Pubmed	Model of OSBP-Mediated Cholesterol Supply to Aichi Virus RNA Replication Sites Involving Protein-Protein Interactions among Viral Proteins, ACBD3, OSBP, VAP-A/B, and SAC1.	VAPB ACBD3	2.10e-05	5	51	2	29367253
Pubmed	Intraovarian regulation of gonadotropin-dependent folliculogenesis depends on notch receptor signaling pathways not involving Delta-like ligand 4 (Dll4).	NOTCH2 NOTCH4	2.10e-05	5	51	2	23675950
Pubmed	MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors.	NOTCH2 NOTCH4	2.10e-05	5	51	2	11101851
Pubmed	CD8- DCs induce IL-12-independent Th1 differentiation through Delta 4 Notch-like ligand in response to bacterial LPS.	IL12B NOTCH4	2.10e-05	5	51	2	17576775
Pubmed	Functional redundancy of the Notch gene family during mouse embryogenesis: analysis of Notch gene expression in Notch3-deficient mice.	NOTCH2 NOTCH4	2.10e-05	5	51	2	15882997
Pubmed	Association of Notch pathway down-regulation with Triple Negative/Basal-like breast carcinomas and high tumor-infiltrating FOXP3+ Tregs.	NOTCH2 NOTCH4	2.10e-05	5	51	2	27118257
Pubmed	The interaction of PP1 with BRCA1 and analysis of their expression in breast tumors.	BRCA1 PPP1CA	2.10e-05	5	51	2	17511879
Pubmed	HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.	ASNSD1 VAPB PTBP3 AIMP2 RAE1 RBMS1 HADHA CLIP1 GNL3 LACTB	2.56e-05	1371	51	10	36244648
Pubmed	SARS-CoV-2 N Protein Antagonizes Stress Granule Assembly and IFN Production by Interacting with G3BPs to Facilitate Viral Replication.	PPAN HADHA CDC73 GNL3 HNRNPR	3.00e-05	245	51	5	35652658
Pubmed	RBP-L, a transcription factor related to RBP-Jkappa.	NOTCH2 NOTCH4	3.15e-05	6	51	2	9111338
Pubmed	Notch signaling is a critical regulator of allogeneic CD4+ T-cell responses mediating graft-versus-host disease.	NOTCH2 NOTCH4	3.15e-05	6	51	2	20870902
Pubmed	Characterization of Notch receptor expression in the developing mammalian heart and liver.	NOTCH2 NOTCH4	3.15e-05	6	51	2	12244553
Pubmed	Hairy-related transcription factors inhibit Notch-induced smooth muscle alpha-actin expression by interfering with Notch intracellular domain/CBF-1 complex interaction with the CBF-1-binding site.	NOTCH2 NOTCH4	3.15e-05	6	51	2	18239137
Pubmed	Notch4 Negatively Regulates the Inflammatory Response to Mycobacterium tuberculosis Infection by Inhibiting TAK1 Activation.	NOTCH2 NOTCH4	3.15e-05	6	51	2	29228365
Pubmed	Epidermal growth factor-like domain 7 (EGFL7) modulates Notch signalling and affects neural stem cell renewal.	NOTCH2 NOTCH4	3.15e-05	6	51	2	19503073
Pubmed	Interaction with factor inhibiting HIF-1 defines an additional mode of cross-coupling between the Notch and hypoxia signaling pathways.	NOTCH2 NOTCH4	3.15e-05	6	51	2	18299578
Pubmed	Cloning and functional characterization of the murine mastermind-like 1 (Maml1) gene.	NOTCH2 NOTCH4	3.15e-05	6	51	2	15019995
Pubmed	Notch controls the magnitude of T helper cell responses by promoting cellular longevity.	NOTCH2 NOTCH4	3.15e-05	6	51	2	22615412
Pubmed	Notch lineages and activity in intestinal stem cells determined by a new set of knock-in mice.	NOTCH2 NOTCH4	3.15e-05	6	51	2	21991352
Pubmed	A protein interaction landscape of breast cancer.	BRCA1 RAE1 HADHA CDC73 MCM10 PPP1CA HNRNPR	3.74e-05	634	51	7	34591612
Pubmed	Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS.	VAPB RAE1 HADHA ZNF568 GNL3 PPP1CA	3.98e-05	432	51	6	23455922
Pubmed	Human ligands of the Notch receptor.	NOTCH2 NOTCH4	4.41e-05	7	51	2	10079256
Pubmed	Loss of Notch2 and Notch3 in vascular smooth muscle causes patent ductus arteriosus.	MYOCD NOTCH2	4.41e-05	7	51	2	26453897
Pubmed	Functional interactions between Fat family cadherins in tissue morphogenesis and planar polarity.	FAT4 FAT3	4.41e-05	7	51	2	22510986
Pubmed	The distribution of Notch receptors and their ligands during articular cartilage development.	NOTCH2 NOTCH4	4.41e-05	7	51	2	12846471
Pubmed	Murine notch homologs (N1-4) undergo presenilin-dependent proteolysis.	NOTCH2 NOTCH4	4.41e-05	7	51	2	11518718
Pubmed	Expression of mouse dchs1, fjx1, and fat-j suggests conservation of the planar cell polarity pathway identified in Drosophila.	FAT4 FAT3	4.41e-05	7	51	2	16059920
Pubmed	Cranial neural crest ablation of Jagged1 recapitulates the craniofacial phenotype of Alagille syndrome patients.	NOTCH2 NOTCH4	5.87e-05	8	51	2	22156581
Pubmed	CSB interacts with BRCA1 in late S/G2 to promote MRN- and CtIP-mediated DNA end resection.	ERCC6 BRCA1	5.87e-05	8	51	2	31501894
Pubmed	Notch1 and Jagged1 expression by the developing pulmonary vasculature.	NOTCH2 NOTCH4	5.87e-05	8	51	2	12242716
Pubmed	Distinct expression patterns of notch family receptors and ligands during development of the mammalian inner ear.	NOTCH2 NOTCH4	5.87e-05	8	51	2	9858718
Pubmed	Nuclear Functions of Nucleolin through Global Proteomics and Interactomic Approaches.	PPAN CDC73 GNL3 HNRNPR	6.22e-05	145	51	4	27049334
Pubmed	Common genetic variants in candidate genes and risk of familial lymphoid malignancies.	IL12B CASP8AP2 ERCC6 BRCA1	6.22e-05	145	51	4	19573080
Pubmed	Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.	PTBP3 PPAN AIMP2 RAE1 HADHA ACBD3 GNL3 PPP1CA HNRNPR	7.45e-05	1247	51	9	27684187
Pubmed	Dynamic expression patterns of the pudgy/spondylocostal dysostosis gene Dll3 in the developing nervous system.	NOTCH2 NOTCH4	7.54e-05	9	51	2	11118901
Pubmed	Notch1 signals through Jagged2 to regulate apoptosis in the apical ectodermal ridge of the developing limb bud.	NOTCH2 NOTCH4	7.54e-05	9	51	2	16245338
Pubmed	Identification of a family of mastermind-like transcriptional coactivators for mammalian notch receptors.	NOTCH2 NOTCH4	7.54e-05	9	51	2	12370315
Pubmed	Poly(ADP-ribosyl)ation of BRD7 by PARP1 confers resistance to DNA-damaging chemotherapeutic agents.	PTBP3 PPAN HADHA CDC73 GNL3 HNRNPR	7.63e-05	486	51	6	30940648
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	PPAN ERCC6 AIMP2 HADHA GNL3 LACTB PPP1CA NOL8 HNRNPR	7.92e-05	1257	51	9	36526897
Pubmed	Prohibitin 1 regulates tumor cell apoptosis via the interaction with X-linked inhibitor of apoptosis protein.	VAPB AIMP2 RBMS1 HADHA GNL3 LACTB HNRNPR	8.67e-05	725	51	7	27025967
Pubmed	Multiple myeloma-associated chromosomal translocation activates orphan snoRNA ACA11 to suppress oxidative stress.	HADHA GNL3 ELOVL7 HNRNPR	8.89e-05	159	51	4	22751105
Pubmed	Spatiotemporal expression of Notch receptors and ligands in developing mouse placenta.	NOTCH2 NOTCH4	9.42e-05	10	51	2	23665443
Pubmed	Notch4 signaling limits regulatory T-cell-mediated tissue repair and promotes severe lung inflammation in viral infections.	NOTCH2 NOTCH4	9.42e-05	10	51	2	33915108
Pubmed	TNRC6 proteins modulate hepatitis C virus replication by spatially regulating the binding of miR-122/Ago2 complexes to viral RNA.	PTBP3 RBMS1 HADHA GNL3 LRRC17	1.02e-04	317	51	5	30997501
Pubmed	The E3 ubiquitin ligase and RNA-binding protein ZNF598 orchestrates ribosome quality control of premature polyadenylated mRNAs.	VAPB AIMP2 CDC73 CLIP1 NOTCH2	1.06e-04	320	51	5	28685749
Pubmed	BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.	PTBP3 PPAN AIMP2 RAE1 HADHA GNL3 NOTCH2 PPP1CA HNRNPR	1.14e-04	1318	51	9	30463901
Pubmed	Jag2-Notch1 signaling regulates oral epithelial differentiation and palate development.	NOTCH2 NOTCH4	1.15e-04	11	51	2	16607638
Pubmed	Coexpression of Cux-1 and Notch signaling pathway components during kidney development.	NOTCH2 NOTCH4	1.15e-04	11	51	2	15499562
Pubmed	Damage-induced ubiquitylation of human RNA polymerase II by the ubiquitin ligase Nedd4, but not Cockayne syndrome proteins or BRCA1.	ERCC6 BRCA1	1.15e-04	11	51	2	17996703
Pubmed	Localisation of members of the notch system and the differentiation of vibrissa hair follicles: receptors, ligands, and fringe modulators.	NOTCH2 NOTCH4	1.15e-04	11	51	2	10878608
Pubmed	A family of mammalian Fringe genes implicated in boundary determination and the Notch pathway.	NOTCH2 NOTCH4	1.15e-04	11	51	2	9187150
Pubmed	Notch-associated gene expression in embryonic and adult taste papillae and taste buds suggests a role in taste cell lineage decisions.	NOTCH2 NOTCH4	1.15e-04	11	51	2	12866128
Pubmed	Cell cycle-dependent phosphorylation regulates RECQL4 pathway choice and ubiquitination in DNA double-strand break repair.	VAPB AIMP2 HADHA MCM10 ACBD3 GNL3 LACTB PPP1CA HNRNPR	1.25e-04	1335	51	9	29229926
Pubmed	Tagging genes with cassette-exchange sites.	VAPB CDC73 MCM10 PRDM5 GNL3	1.31e-04	335	51	5	15741177
Pubmed	Mindbomb 1, an E3 ubiquitin ligase, forms a complex with RYK to activate Wnt/β-catenin signaling.	FAT4 FAT3 ADGRA3	1.33e-04	67	51	3	21875946
Pubmed	TRIM27 cooperates with STK38L to inhibit ULK1-mediated autophagy and promote tumorigenesis.	CCPG1 HADHA PPP1CA	1.33e-04	67	51	3	35670107
Pubmed	Basic helix-loop-helix transcription factors regulate the neuroendocrine differentiation of fetal mouse pulmonary epithelium.	NOTCH2 NOTCH4	1.38e-04	12	51	2	10952889
Pubmed	Developmental expression of the Notch signaling pathway genes during mouse preimplantation development.	NOTCH2 NOTCH4	1.38e-04	12	51	2	15465494
Pubmed	A regulatory T cell Notch4-GDF15 axis licenses tissue inflammation in asthma.	NOTCH2 NOTCH4	1.63e-04	13	51	2	32929274
Pubmed	Vascular expression of Notch pathway receptors and ligands is restricted to arterial vessels.	NOTCH2 NOTCH4	1.63e-04	13	51	2	11578869
Pubmed	Inhibition of notch1-dependent cardiomyogenesis leads to a dilated myopathy in the neonatal heart.	NOTCH2 NOTCH4	1.63e-04	13	51	2	20558824
Pubmed	MKRN2 Physically Interacts with GLE1 to Regulate mRNA Export and Zebrafish Retinal Development.	MAGI2 SEMA4B ERCC6 RAE1 NOTCH2	1.79e-04	358	51	5	32460013
Pubmed	Cell-fate transition and determination analysis of mouse male germ cells throughout development.	NOTCH2 NOTCH4	1.90e-04	14	51	2	34824237
Interaction	MKRN2 interactions	MAGI2 PTBP3 SEMA4B ERCC6 BRCA1 RAE1 RBMS1 NOTCH2 HNRNPR	3.23e-07	385	49	9	int:MKRN2
Interaction	DCLRE1A interactions	ERCC6 BRCA1 DCLRE1A	1.50e-05	20	49	3	int:DCLRE1A
Interaction	DTX4 interactions	FAT4 FAT3 NOTCH2	2.01e-05	22	49	3	int:DTX4
Interaction	ZBTB48 interactions	BRCA1 SPANXN2 MYOCD PRDM5 NOTCH2	4.01e-05	158	49	5	int:ZBTB48
Interaction	XCL1 interactions	FAT4 FAT3 CXCL11	4.24e-05	28	49	3	int:XCL1
Interaction	ZBBX interactions	FAT4 FAT3 ZBBX	5.79e-05	31	49	3	int:ZBBX
Interaction	MIR29A interactions	PTBP3 AIMP2 RBMS1 HNRNPR	5.92e-05	87	49	4	int:MIR29A
Interaction	MIR92A2 interactions	PTBP3 AIMP2 RBMS1 HNRNPR	6.76e-05	90	49	4	int:MIR92A2
Interaction	MIR205 interactions	PTBP3 AIMP2 RBMS1 HNRNPR	7.68e-05	93	49	4	int:MIR205
Interaction	RABEP1 interactions	ZNF438 AIMP2 CDC73 CLIP1 PPP1CA	8.27e-05	184	49	5	int:RABEP1
Interaction	MIR7-1 interactions	PTBP3 AIMP2 RBMS1 HNRNPR	1.14e-04	103	49	4	int:MIR7-1
Interaction	SPATA4 interactions	BRCA1 FAT3	1.21e-04	7	49	2	int:SPATA4
Interaction	MAP4 interactions	AIMP2 BRCA1 RAE1 MCM10 PPP1CA HNRNPR	1.29e-04	324	49	6	int:MAP4
Interaction	LGALS1 interactions	FAT4 RAE1 FAT3 HADHA NOTCH2 ADGRA3	1.47e-04	332	49	6	int:LGALS1
Interaction	DDX23 interactions	ERCC6 BRCA1 CDC73 ACBD3 GNL3 NOL8 HNRNPR	1.50e-04	480	49	7	int:DDX23
GeneFamily	Cadherin related	FAT4 FAT3	3.81e-04	17	31	2	24
GeneFamily	RNA binding motif containing	PTBP3 RBMS1 NOL8 HNRNPR	4.59e-04	213	31	4	725
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF438 ZNF605 ZNF41 PRDM5 ZNF568 ZNF248	1.21e-03	718	31	6	28
Coexpression	GEORGES_CELL_CYCLE_MIR192_TARGETS	BRCA1 CDC73 MCM10 PPP1CA	6.02e-06	62	50	4	M11038
Coexpression	SCHAEFFER_PROSTATE_DEVELOPMENT_6HR_DN	FAT4 ARHGAP29 MYOCD LACTB RFWD3 PPP1CA NOL8	2.81e-05	467	50	7	M1347
Coexpression	SCHAEFFER_PROSTATE_DEVELOPMENT_6HR_DN	FAT4 ARHGAP29 MYOCD LACTB RFWD3 PPP1CA NOL8	3.52e-05	484	50	7	MM999
Coexpression	GSE24634_TEFF_VS_TCONV_DAY10_IN_CULTURE_UP	PTBP3 BRCA1 DCLRE1A CDC73 MCM10	3.94e-05	200	50	5	M4626
CoexpressionAtlas	dev gonad_e12.5_F_VasAssMesen_MafB_top-relative-expression-ranked_1000	MAGI2 FAT4 RBMS1 FAT3 ARHGAP29 ZC3H12B HADHA NOTCH2 ADGRA3 LRRC17	9.78e-06	783	49	10	gudmap_dev gonad_e12.5_F_VasAssMesen_MafB_1000
CoexpressionAtlas	FacebaseRNAseq_e10.5_Neural Epithelium Overlying Central Eminence_top-relative-expression-ranked_1000_k-means-cluster#4	CASP8AP2 ZNF605 ERCC6 BRCA1 FAT3 CLIP1	6.12e-05	298	49	6	Facebase_RNAseq_e10.5_Neural Epithelium Overlying Central Eminence_1000_K4
ToppCell	wk_15-18-Mesenchymal-Myofibro_&_SMC-Myofibro_3\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	FAT4 PPAN FAT3 ZC3H12B MCM10 ADGRA3	3.79e-08	164	52	6	583dda853cee9491dbdcb228c23d8deadc20eb08
ToppCell	PCW_05-06-Mesenchymal-Mesenchymal_myocytic-mes_proliferating_SM_(20)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	BRCA1 FAT3 MYOCD MCM10 RFWD3	2.82e-06	190	52	5	e83fa8b711aa79a1767818474f1c193b674b1c31
ToppCell	Hematolymphoid-Endothelial-NOSTRIN\|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic	MAGI2 ARHGAP29 ZC3H12B NOTCH4 ELOVL7	3.62e-06	200	52	5	032df80aa5c40991e1c1e80f9d8da106e6aeaee2
ToppCell	Hematolymphoid-Endothelial-NOSTRIN--\|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic	MAGI2 ARHGAP29 ZC3H12B NOTCH4 ELOVL7	3.62e-06	200	52	5	7fa54370221ed61bac0e09e6bcf1f3dff202a846
ToppCell	Hematolymphoid-Endothelial-NOSTRIN---\|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic	MAGI2 ARHGAP29 ZC3H12B NOTCH4 ELOVL7	3.62e-06	200	52	5	68fce28690246895fd33354b30960ebcc31aa4cc
ToppCell	Hematolymphoid-Endothelial-NOSTRIN-\|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic	MAGI2 ARHGAP29 ZC3H12B NOTCH4 ELOVL7	3.62e-06	200	52	5	376b19ab5a7cd2c85f726d8ba41337d4525863e5
ToppCell	Hematolymphoid-Endothelial-NOSTRIN----L2-6\|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic	MAGI2 ARHGAP29 ZC3H12B NOTCH4 ELOVL7	3.62e-06	200	52	5	878bbbe32e3602723aa14ef32877ab2453b8c6e5
ToppCell	Hematolymphoid-Endothelial\|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic	MAGI2 ARHGAP29 ZC3H12B NOTCH4 ELOVL7	3.62e-06	200	52	5	7136936d05ab344a560cf159684c881063b5430d
ToppCell	PND03-Immune-Immune_Myeloid-Monocytic-Macrophage-iMON-iMON_prolif\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CASP8AP2 CYSLTR1 NOTCH2 RFWD3	3.39e-05	157	52	4	eea53cf8d8a607264e1ee00b7a97c94bcf2ac80d
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Glomerular_Capillary_Endothelial_Cell_prolif\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CASP8AP2 ZNF605 RBMS1 NOTCH4	4.95e-05	173	52	4	f193c63cc536d891c9d23043765e320252bb6e65
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_S-high\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CASP8AP2 BRCA1 MCM10 RFWD3	5.65e-05	179	52	4	88d44b04eb5c079531db663ed98ddb20b60feb9a
ToppCell	3'-GW_trimst-2-SmallIntestine-Endothelial-blood_vessel_EC-cycling_EC\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	BRCA1 ARHGAP29 MCM10 NOTCH4	6.29e-05	184	52	4	fa38d6a8709f520a027ad7e3ff783c84187ec467
ToppCell	normal-na-Lymphocytic-lymphocyte-male\|normal / PBMC cell types (v2) per disease, treatment status, and sex	XYLT1 ERCC6 BRCA1 MCM10	6.29e-05	184	52	4	2c286712428662bc4589dc5ac4011bf7ed403cb5
ToppCell	Control-Stromal_mesenchymal-Lung_smooth_muscle\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	MAGI2 FAT3 MYOCD NOTCH2	6.98e-05	189	52	4	45e588b2a4ad9e3ff74e22d9d627ed3571f3b8b8
ToppCell	Fetal_29-31_weeks-Mesenchymal-matrix_fibroblast_1_cell-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	RBMS1 FAT3 CLIP1 ADGRA3	7.27e-05	191	52	4	08720998aa55131d7377c4c67c4c935865bd7d79
ToppCell	Control-Stromal_mesenchymal\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	MAGI2 FAT3 MYOCD NOTCH2	7.27e-05	191	52	4	14057205ddb9b4bbc582d1358d13cf36d979a61b
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PTBP3 SEMA4B ARHGAP29 CLIP1	7.41e-05	192	52	4	f7e7491426bbd6ed29a465b58bf67acb93dbb90a
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Glomerular_Capillary_Endothelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ZNF438 FAT4 RBMS1 NOTCH4	7.56e-05	193	52	4	456aa8a8f1f9cbba0bd618a5f623909079c0f56b
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_myocytic-mes_proliferating_SM_(20)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	BRCA1 MYOCD MCM10 RFWD3	7.56e-05	193	52	4	bbdfda6665941cfa1965418bb91ef9ff43b1326f
ToppCell	PCW_05-06-Mesenchymal\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	MAGI2 FAT4 NOTCH2 LRRC17	8.03e-05	196	52	4	dca52c57ba35d9395cdbca8b881f12ece721b10f
ToppCell	Fetal_29-31_weeks-Mesenchymal\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	MAGI2 FAT4 FAT3 LRRC17	8.35e-05	198	52	4	21cf4d81386761d09d0f6829c01c198e5524176d
Disease	Familial Isolated Hyperparathyroidism	GCM2 CDC73	1.62e-05	4	49	2	C4551961
Disease	hyperparathyroidism (is_implicated_in)	GCM2 CDC73	2.69e-05	5	49	2	DOID:13543 (is_implicated_in)
Disease	MENTAL RETARDATION, AUTOSOMAL DOMINANT 40	BRCA1 HNRNPR	9.65e-05	9	49	2	C4225275
Disease	Fanconi anemia (is_implicated_in)	BRCA1 RFWD3	1.21e-04	10	49	2	DOID:13636 (is_implicated_in)
Disease	Malignant neoplasm of breast	ZNF438 ERCC6 BRCA1 ARHGAP29 CLIP1 NOTCH2 NOTCH4 HNRNPR	3.59e-04	1074	49	8	C0006142
Disease	obesity (implicated_via_orthology)	FAT4 GNL3 NOTCH2 NOTCH4	4.49e-04	215	49	4	DOID:9970 (implicated_via_orthology)
Disease	Squamous cell carcinoma of esophagus	FAT4 FAT3 NOTCH2	5.35e-04	95	49	3	C0279626
Disease	Hepatitis	FAT4 ARHGAP29	6.11e-04	22	49	2	HP_0012115
Disease	West Syndrome	MAGI2 AIMP2	7.28e-04	24	49	2	C0037769
Disease	Fanconi Anemia	BRCA1 RFWD3	7.91e-04	25	49	2	C0015625
Disease	Neoplasm of uncertain or unknown behavior of ovary	ERCC6 BRCA1	1.07e-03	29	49	2	C0496920
Disease	Ovarian Carcinoma	ERCC6 BRCA1	1.14e-03	30	49	2	C0029925
Disease	Epileptic encephalopathy	MAGI2 AIMP2	1.14e-03	30	49	2	C0543888

Protein segments in the cluster

Peptide	Gene	Start	Entry
FVPSDEKKKQGCQRE	CDC73	386	Q6P1J9
EKGNRKKELRQANCP	ADAMTSL4-AS1	66	Q5T5F5
YKQVTKKAKRCQDPD	ADGRA3	851	Q8IWK6
CNQCRGKKAKNPKEE	FAT4	4526	Q6V0I7
NKENQKPIYKSDKCT	CASP8AP2	906	Q9UKL3
KKQGCNKRAARKAPA	ERCC6	286	Q03468
KKPAGEASNSNKKCK	C17orf113	6	A0A1B0GUU1
RCVAIFKDKQNKPTG	RAE1	216	P78406
CKFADGGQKKRQNPN	RBMS1	221	P29558
KGQVRKCPQCNKKAR	RFWD3	321	Q6PCD5
CKNCGKKFPVKQALQ	PRDM5	201	Q9NQX1
KKQGCNKRAARKAPA	ERCC6	286	P0DP91
PCKNKGTCVQKKAES	NOTCH2	1071	Q04721
KPKELSACGQKKQRL	MAGI2	1296	Q86UL8
KCESPQEQKNKKLRQ	LRRC17	191	Q8N6Y2
NEAKCRNSKPGKKKN	LACTB	271	P83111
QPDDKKKNRGFCFLE	HNRNPR	281	O43390
IGCEEKAKKNANKPL	ACBD3	461	Q9H3P7
KAKKKNGEPCTQTVN	MCM10	391	Q7L590
GEENTCGKQKPKENN	NOL8	551	Q76FK4
KEPKNKTFLRCEAKN	IL12B	121	P29460
KQKRNNCSEKKPLPF	MYOCD	551	Q8IZQ8
CSFQILKPADKNKGK	PPP1CA	291	P62136
KFCKNPAFEGVNRKD	ARHGAP29	1046	Q52LW3
KAEFCNKSKQPGLAR	BRCA1	301	P38398
KEFRKNTNSKKCSPG	CCPG1	601	Q9ULG6
RLPKTVKNGTCKNKD	ELOVL7	266	A1L3X0
QAKDKGSPQKCSALK	FAT3	346	Q8TDW7
GNKQKNKCEIPSEEF	ASNSD1	371	Q9NWL6
QVLCKKNKFGAPQKD	HADHA	346	P40939
GLCKTENKAKSGKQN	GNL3	111	Q9BVP2
PNQKRSSQCKRKAEK	DCLRE1A	591	Q6PJP8
DKSCTFKKPQQCDRK	CCDC168	896	Q8NDH2
FKKPQQCDRKEQEKE	CCDC168	901	Q8NDH2
LKENKGQRCLNPKSK	CXCL11	66	O14625
DQEKQSKKKPRLFCD	CLIP1	1366	P30622
KCSFNQKPQDPGDKE	FXYD6P3	61	P58550
CDKARLKQQKKACPN	GCM2	106	O75603
KKQQCSFKGKDPQRD	SEMA4B	116	Q9NPR2
PKQICKDQKDKANCL	NOTCH4	636	Q99466
LKCFGEQNKKQPRQD	AIMP2	166	Q13155
AKPQKDEKNNTKCFE	CYSLTR1	161	Q9Y271
KVTRFCPLEGKANKN	XYLT1	296	Q86Y38
KGCVREKQSNEFGKP	ZNF568	196	Q3ZCX4
LCDQKFPKTKDKSQG	PPAN	431	Q9NQ55
EKRKSPCESNNKKND	SPANXN2	11	Q5MJ10
NGNDSKKFKRDRPPC	PTBP3	41	O95758
NSKSCQPRDGQLKKK	ZC3H12B	56	Q5HYM0
RECDKSNKVFPQKPQ	ZNF41	341	P51814
KLGNPTDRNVCFKVK	VAPB	31	O95292
NKCRDGKERVKNDPQ	ZNF438	406	Q7Z4V0
PKNNCERKKIDELNK	ZNF605	111	Q86T29
SKKNCSRKKPDEFNV	ZNF248	156	Q8NDW4
KPKINGKVCGQCENK	ZBBX	126	A8MT70