Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	low voltage-gated calcium channel activity	CACNA1H CACNA1G	4.28e-05	3	76	2	GO:0008332
GeneOntologyMolecularFunction	metal ion transmembrane transporter activity	SLC11A2 SLC10A5 CACNA1H SLC10A3 CACNA1G TMCO3 SLC30A10 SLC39A8 CACNA2D3	6.67e-05	465	76	9	GO:0046873
GeneOntologyMolecularFunction	solute:monoatomic cation symporter activity	SLC11A2 SLC2A9 SLC10A5 SLC10A3 SLC39A8	9.11e-05	119	76	5	GO:0015294
GeneOntologyMolecularFunction	inorganic cation transmembrane transporter activity	SLC11A2 SLC2A9 SLC10A5 CACNA1H SLC10A3 CACNA1G TMCO3 SLC30A10 SLC39A8 CACNA2D3	1.28e-04	627	76	10	GO:0022890
GeneOntologyMolecularFunction	secondary active transmembrane transporter activity	SLC11A2 SLC2A9 SLC10A5 SLC10A3 TMCO3 SLC30A10 SLC39A8	1.34e-04	296	76	7	GO:0015291
GeneOntologyMolecularFunction	active monoatomic ion transmembrane transporter activity	SLC11A2 SLC2A9 SLC10A5 SLC10A3 TMCO3 SLC30A10 SLC39A8	1.48e-04	301	76	7	GO:0022853
GeneOntologyMolecularFunction	monoatomic cation transmembrane transporter activity	SLC11A2 SLC2A9 SLC10A5 CACNA1H SLC10A3 CACNA1G TMCO3 SLC30A10 SLC39A8 CACNA2D3	2.04e-04	664	76	10	GO:0008324
GeneOntologyMolecularFunction	bile acid:sodium symporter activity	SLC10A5 SLC10A3	2.12e-04	6	76	2	GO:0008508
GeneOntologyMolecularFunction	symporter activity	SLC11A2 SLC2A9 SLC10A5 SLC10A3 SLC39A8	2.69e-04	150	76	5	GO:0015293
GeneOntologyMolecularFunction	inorganic molecular entity transmembrane transporter activity	SLC11A2 SLC2A9 SLC10A5 CACNA1H SLC10A3 CACNA1G TMCO3 SLC30A10 SLC39A8 CACNA2D3	5.81e-04	758	76	10	GO:0015318
GeneOntologyMolecularFunction	transition metal ion transmembrane transporter activity	SLC11A2 SLC30A10 SLC39A8	6.27e-04	44	76	3	GO:0046915
GeneOntologyMolecularFunction	manganese ion transmembrane transporter activity	SLC11A2 SLC30A10	6.31e-04	10	76	2	GO:0005384
GeneOntologyMolecularFunction	voltage-gated calcium channel activity	CACNA1H CACNA1G CACNA2D3	7.15e-04	46	76	3	GO:0005245
GeneOntologyMolecularFunction	monoatomic ion transmembrane transporter activity	SLC11A2 SLC2A9 SLC10A5 CACNA1H SLC10A3 CACNA1G TMCO3 SLC30A10 SLC39A8 CACNA2D3	8.22e-04	793	76	10	GO:0015075
GeneOntologyMolecularFunction	clathrin heavy chain binding	SNAP91 PICALM	9.21e-04	12	76	2	GO:0032050
GeneOntologyMolecularFunction	high voltage-gated calcium channel activity	CACNA1H CACNA1G	1.26e-03	14	76	2	GO:0008331
GeneOntologyMolecularFunction	monocarboxylate:sodium symporter activity	SLC10A5 SLC10A3	1.45e-03	15	76	2	GO:0140161
GeneOntologyMolecularFunction	1-phosphatidylinositol binding	SNAP91 PICALM	1.87e-03	17	76	2	GO:0005545
GeneOntologyMolecularFunction	active transmembrane transporter activity	SLC11A2 SLC2A9 SLC10A5 SLC10A3 TMCO3 SLC30A10 SLC39A8	2.25e-03	477	76	7	GO:0022804
GeneOntologyMolecularFunction	secondary active monocarboxylate transmembrane transporter activity	SLC10A5 SLC10A3	2.34e-03	19	76	2	GO:0015355
GeneOntologyMolecularFunction	calcium ion transmembrane transporter activity	CACNA1H CACNA1G SLC30A10 CACNA2D3	2.64e-03	151	76	4	GO:0015085
GeneOntologyMolecularFunction	zinc ion transmembrane transporter activity	SLC30A10 SLC39A8	3.74e-03	24	76	2	GO:0005385
GeneOntologyMolecularFunction	solute:proton symporter activity	SLC11A2 SLC2A9	4.05e-03	25	76	2	GO:0015295
GeneOntologyMolecularFunction	sodium ion transmembrane transporter activity	SLC10A5 CACNA1H SLC10A3 CACNA1G	4.13e-03	171	76	4	GO:0015081
GeneOntologyMolecularFunction	voltage-gated sodium channel activity	CACNA1H CACNA1G	4.38e-03	26	76	2	GO:0005248
GeneOntologyMolecularFunction	transmembrane transporter activity	SLC11A2 SLC2A9 TOMM40L SLC10A5 CACNA1H SLC10A3 CACNA1G TMCO3 SLC30A10 SLC39A8 CACNA2D3	4.89e-03	1180	76	11	GO:0022857
GeneOntologyMolecularFunction	glutathione peroxidase activity	GSTT2 GSTT2B	5.07e-03	28	76	2	GO:0004602
GeneOntologyMolecularFunction	glutathione transferase activity	GSTT2 GSTT2B	5.43e-03	29	76	2	GO:0004364
GeneOntologyBiologicalProcess	manganese ion transmembrane transport	SLC11A2 SLC30A10 SLC39A8	1.07e-05	12	77	3	GO:0071421
GeneOntologyBiologicalProcess	manganese ion transport	SLC11A2 SLC30A10 SLC39A8	1.77e-05	14	77	3	GO:0006828
GeneOntologyBiologicalProcess	intracellular manganese ion homeostasis	SLC30A10 SLC39A8	4.12e-05	3	77	2	GO:0030026
GeneOntologyBiologicalProcess	manganese ion homeostasis	SLC30A10 SLC39A8	8.21e-05	4	77	2	GO:0055071
GeneOntologyBiologicalProcess	regulation of terminal button organization	SNAP91 PICALM	8.21e-05	4	77	2	GO:2000331
GeneOntologyBiologicalProcess	cadmium ion transport	SLC11A2 SLC39A8	2.04e-04	6	77	2	GO:0015691
GeneOntologyBiologicalProcess	cadmium ion transmembrane transport	SLC11A2 SLC39A8	2.04e-04	6	77	2	GO:0070574
Domain	ARM-like	ARID1B MROH1 HGH1 TOGARAM1 BTAF1 UNC45A CUL7 TNPO3 XPO7	1.48e-06	270	76	9	IPR011989
Domain	-	ARID1B MROH1 HGH1 TOGARAM1 BTAF1 UNC45A CUL7 TNPO3	3.31e-06	222	76	8	1.25.10.10
Domain	Clathrin_AP_2	SNAP91 PICALM	1.63e-05	2	76	2	IPR014712
Domain	-	SNAP91 PICALM	1.63e-05	2	76	2	1.20.58.150
Domain	Cul7	CUL7 HERC2	4.89e-05	3	76	2	PF11515
Domain	VDCC_T_a1	CACNA1H CACNA1G	4.89e-05	3	76	2	IPR005445
Domain	CPH_domain	CUL7 HERC2	4.89e-05	3	76	2	IPR021097
Domain	ARM-type_fold	MROH1 HGH1 TOGARAM1 BTAF1 UNC45A CUL7 TNPO3 XPO7	6.99e-05	339	76	8	IPR016024
Domain	ANTH_dom	SNAP91 PICALM	9.75e-05	4	76	2	IPR011417
Domain	ANTH	SNAP91 PICALM	9.75e-05	4	76	2	PF07651
Domain	BilAc:Na_symport/Acr3	SLC10A5 SLC10A3	3.39e-04	7	76	2	IPR002657
Domain	APC_su10/DOC_dom	CUL7 HERC2	3.39e-04	7	76	2	IPR004939
Domain	SBF	SLC10A5 SLC10A3	3.39e-04	7	76	2	PF01758
Domain	DOC	CUL7 HERC2	3.39e-04	7	76	2	PS51284
Domain	APC10	CUL7 HERC2	3.39e-04	7	76	2	SM01337
Domain	ANAPC10	CUL7 HERC2	3.39e-04	7	76	2	PF03256
Domain	ENTH	SNAP91 PICALM	5.77e-04	9	76	2	PS50942
Domain	ENTH	SNAP91 PICALM	5.77e-04	9	76	2	SM00273
Domain	ENTH	SNAP91 PICALM	7.20e-04	10	76	2	IPR013809
Domain	VDCCAlpha1	CACNA1H CACNA1G	7.20e-04	10	76	2	IPR002077
Domain	Leu-rich_rpt_typical-subtyp	PPP1R7 MFHAS1 LGR6 LRRC28 LRIT1	7.75e-04	177	76	5	IPR003591
Domain	LRR_TYP	PPP1R7 MFHAS1 LGR6 LRRC28 LRIT1	7.75e-04	177	76	5	SM00369
Domain	HEAT	MROH1 TOGARAM1 BTAF1	1.70e-03	58	76	3	IPR000357
Domain	LRR_1	PPP1R7 MFHAS1 LGR6 LRRC28 LRIT1	1.99e-03	219	76	5	PF00560
Domain	Rib_L2_dom2	CUL7 HERC2	2.40e-03	18	76	2	IPR014722
Domain	-	CUL7 HERC2	2.40e-03	18	76	2	2.30.30.30
Domain	HEAT_REPEAT	MROH1 TOGARAM1 BTAF1	2.91e-03	70	76	3	PS50077
Domain	-	EPHB4 CUL7 HERC2	3.28e-03	73	76	3	2.60.120.260
Domain	GST_N	GSTT2 GSTT2B	3.58e-03	22	76	2	PF02798
Domain	GST_NTER	GSTT2 GSTT2B	3.58e-03	22	76	2	PS50404
Domain	Actinin_actin-bd_CS	SYNE2 MACF1	3.91e-03	23	76	2	IPR001589
Domain	Spectrin	SYNE2 MACF1	3.91e-03	23	76	2	PF00435
Domain	ACTININ_2	SYNE2 MACF1	3.91e-03	23	76	2	PS00020
Domain	ACTININ_1	SYNE2 MACF1	3.91e-03	23	76	2	PS00019
Domain	Leu-rich_rpt	PPP1R7 MFHAS1 LGR6 LRRC28 LRIT1	4.95e-03	271	76	5	IPR001611
Domain	GST_C	GSTT2 GSTT2B	4.99e-03	26	76	2	IPR004046
Domain	-	SNAP91 PICALM	4.99e-03	26	76	2	1.25.40.90
Domain	GST_C	GSTT2 GSTT2B	4.99e-03	26	76	2	PF00043
Domain	LRR_8	MFHAS1 LGR6 LRRC28 LRIT1	5.22e-03	171	76	4	PF13855
Domain	Glutathione_S-Trfase_N	GSTT2 GSTT2B	5.37e-03	27	76	2	IPR004045
Domain	ENTH_VHS	SNAP91 PICALM	6.18e-03	29	76	2	IPR008942
Domain	Spectrin_repeat	SYNE2 MACF1	6.18e-03	29	76	2	IPR002017
Domain	-	FADD NLRP2B CARD14	6.46e-03	93	76	3	1.10.533.10
Domain	Galactose-bd-like	EPHB4 CUL7 HERC2	6.66e-03	94	76	3	IPR008979
Domain	SNF2_N	BTAF1 CHD7	7.49e-03	32	76	2	IPR000330
Domain	Spectrin/alpha-actinin	SYNE2 MACF1	7.49e-03	32	76	2	IPR018159
Domain	SNF2_N	BTAF1 CHD7	7.49e-03	32	76	2	PF00176
Domain	SPEC	SYNE2 MACF1	7.49e-03	32	76	2	SM00150
Domain	DEATH-like_dom	FADD NLRP2B CARD14	7.68e-03	99	76	3	IPR011029
Pathway	REACTOME_METAL_ION_SLC_TRANSPORTERS	SLC11A2 SLC30A10 SLC39A8	5.47e-05	20	53	3	MM15077
Pathway	REACTOME_METAL_ION_SLC_TRANSPORTERS	SLC11A2 SLC30A10 SLC39A8	9.61e-05	24	53	3	M18795
Pathway	KEGG_MEDICUS_REFERENCE_CA2_ENTRY_VOLTAGE_GATED_CA2_CHANNEL	CACNA1H CACNA1G CACNA2D3	1.09e-04	25	53	3	M47948
Pathway	KEGG_MEDICUS_REFERENCE_FE_TF_TRANSPORT	SLC11A2 SLC39A8	2.88e-04	7	53	2	M47925
Pubmed	Genome-wide and Mendelian randomisation studies of liver MRI yield insights into the pathogenesis of steatohepatitis.	SLC30A10 SLC39A8	4.84e-06	2	77	2	32247823
Pubmed	Identification and characterization of GSTT3, a third murine Theta class glutathione transferase.	GSTT2 GSTT2B	4.84e-06	2	77	2	12038961
Pubmed	Chronic deficit in nitric oxide elicits oxidative stress and augments T-type calcium-channel contribution to vascular tone of rodent arteries and arterioles.	CACNA1H CACNA1G	4.84e-06	2	77	2	23436820
Pubmed	Cav3.2 subunit underlies the functional T-type Ca2+ channel in murine hearts during the embryonic period.	CACNA1H CACNA1G	4.84e-06	2	77	2	14988077
Pubmed	Different distribution of Cav3.2 and Cav3.1 transcripts encoding T-type Ca(2+) channels in the embryonic heart of mice.	CACNA1H CACNA1G	4.84e-06	2	77	2	21079360
Pubmed	Linkage disequilibrium between two high-frequency deletion polymorphisms: implications for association studies involving the glutathione-S transferase (GST) genes.	GSTT2 GSTT2B	4.84e-06	2	77	2	19424424
Pubmed	Diffusional spread and confinement of newly exocytosed synaptic vesicle proteins.	SNAP91 PICALM	4.84e-06	2	77	2	26399746
Pubmed	Polymorphisms in manganese transporters show developmental stage and sex specific associations with manganese concentrations in primary teeth.	SLC30A10 SLC39A8	4.84e-06	2	77	2	28917719
Pubmed	Role of T-type calcium channel subunits in post-myocardial infarction remodelling probed with genetically engineered mice.	CACNA1H CACNA1G	4.84e-06	2	77	2	21622683
Pubmed	Gene structure, expression and chromosomal localization of murine theta class glutathione transferase mGSTT1-1.	GSTT2 GSTT2B	4.84e-06	2	77	2	9854036
Pubmed	Deficiency of T-type Ca2+ channels Cav3.1 and Cav3.2 has no effect on angiotensin II-induced hypertension but differential effect on plasma aldosterone in mice.	CACNA1H CACNA1G	4.84e-06	2	77	2	31042060
Pubmed	Turning CALM into excitement: AP180 and CALM in endocytosis and disease.	SNAP91 PICALM	4.84e-06	2	77	2	22639918
Pubmed	The Ca(v)3.1 T-type calcium channel is required for neointimal formation in response to vascular injury in mice.	CACNA1H CACNA1G	4.84e-06	2	77	2	22886848
Pubmed	Mammalian class theta GST and differential susceptibility to carcinogens: a review.	GSTT2 GSTT2B	4.84e-06	2	77	2	11018744
Pubmed	Characterization of a cDNA and gene encoding the mouse theta class glutathione transferase mGSTT2 and its localization to chromosome 10B5-C1.	GSTT2 GSTT2B	4.84e-06	2	77	2	8617493
Pubmed	A Novel Sequence in AP180 and CALM Promotes Efficient Clathrin Binding and Assembly.	SNAP91 PICALM	4.84e-06	2	77	2	27574975
Pubmed	Ca(v)3.2 T-type Ca2+ channel-dependent activation of ERK in paraventricular thalamus modulates acid-induced chronic muscle pain.	CACNA1H CACNA1G	4.84e-06	2	77	2	20685979
Pubmed	Deletion of T-type calcium channels Cav3.1 or Cav3.2 attenuates endothelial dysfunction in aging mice.	CACNA1H CACNA1G	4.84e-06	2	77	2	29082441
Pubmed	[Decreased mRNA expressions of T-type channel alpha1H and alpha1G in the sperm of varicocele patients and their implication].	CACNA1H CACNA1G	4.84e-06	2	77	2	22574369
Pubmed	Characterization of a human class-Theta glutathione S-transferase with activity towards 1-menaphthyl sulphate.	GSTT2 GSTT2B	4.84e-06	2	77	2	1417752
Pubmed	Blockade of T-type Ca(2+) channels inhibits human ovarian cancer cell proliferation.	CACNA1H CACNA1G	4.84e-06	2	77	2	21438841
Pubmed	T-type voltage-activated calcium channel Cav3.1, but not Cav3.2, is involved in the inhibition of proliferation and apoptosis in MCF-7 human breast cancer cells.	CACNA1H CACNA1G	4.84e-06	2	77	2	22469755
Pubmed	β-Adrenergic stimulation increases Cav3.1 activity in cardiac myocytes through protein kinase A.	CACNA1H CACNA1G	4.84e-06	2	77	2	22808078
Pubmed	Molecular cloning of a cDNA and chromosomal localization of a human theta-class glutathione S-transferase gene (GSTT2) to chromosome 22.	GSTT2 GSTT2B	4.84e-06	2	77	2	7789971
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	ZC3H14 TSR1 SYNE2 MACF1 CHD7 CUL7 HERC2 NUP205 XPO7	1.42e-05	653	77	9	22586326
Pubmed	5,6-EET potently inhibits T-type calcium channels: implication in the regulation of the vascular tone.	CACNA1H CACNA1G	1.45e-05	3	77	2	24327205
Pubmed	Ethanol inhibition of a T-type Ca²+ channel through activity of protein kinase C.	CACNA1H CACNA1G	1.45e-05	3	77	2	23488970
Pubmed	Differential effect of T-type voltage-gated Ca2+ channel disruption on renal plasma flow and glomerular filtration rate in vivo.	CACNA1H CACNA1G	1.45e-05	3	77	2	24966091
Pubmed	T-type channels: release a brake, engage a gear.	CACNA1H CACNA1G	1.45e-05	3	77	2	26488564
Pubmed	Roles of ZIP8, ZIP14, and DMT1 in transport of cadmium and manganese in mouse kidney proximal tubule cells.	SLC11A2 SLC39A8	1.45e-05	3	77	2	22534978
Pubmed	T-type, but not L-type, voltage-gated calcium channels are dispensable for lymphatic pacemaking and spontaneous contractions.	CACNA1H CACNA1G	1.45e-05	3	77	2	31919478
Pubmed	Eps15 Homology Domain-containing Protein 3 Regulates Cardiac T-type Ca2+ Channel Targeting and Function in the Atria.	CACNA1H CACNA1G	1.45e-05	3	77	2	25825486
Pubmed	Differential interactions of Na+ channel toxins with T-type Ca2+ channels.	CACNA1H CACNA1G	1.45e-05	3	77	2	18591418
Pubmed	The clathrin assembly protein AP180 regulates the generation of amyloid-beta peptide.	SNAP91 PICALM	1.45e-05	3	77	2	19450545
Pubmed	Identification of the t-type calcium channel (Ca(v)3.1d) in developing mouse heart.	CACNA1H CACNA1G	1.45e-05	3	77	2	11230107
Pubmed	Alpha(1H) mRNA in single skeletal muscle fibres accounts for T-type calcium current transient expression during fetal development in mice.	CACNA1H CACNA1G	1.45e-05	3	77	2	11897840
Pubmed	Prognostic relevance of a T-type calcium channels gene signature in solid tumours: A correlation ready for clinical validation.	CACNA1H CACNA1G	1.45e-05	3	77	2	28846697
Pubmed	Caveolin-3 regulates protein kinase A modulation of the Ca(V)3.2 (alpha1H) T-type Ca2+ channels.	CACNA1H CACNA1G	1.45e-05	3	77	2	21084288
Pubmed	Homeostatic plasticity and burst activity are mediated by hyperpolarization-activated cation currents and T-type calcium channels in neuronal cultures.	CACNA1H CACNA1G	1.45e-05	3	77	2	33547341
Pubmed	Electric field stimulation unmasks a subtle role for T-type calcium channels in regulating lymphatic contraction.	CACNA1H CACNA1G	1.45e-05	3	77	2	37739992
Pubmed	Glutathione S-transferases promote proinflammatory astrocyte-microglia communication during brain inflammation.	GSTT2 GSTT2B	1.45e-05	3	77	2	30783009
Pubmed	Calmodulin regulates Cav3 T-type channels at their gating brake.	CACNA1H CACNA1G	1.45e-05	3	77	2	28972185
Pubmed	Manganese transport in mammals by zinc transporter family proteins, ZNT and ZIP.	SLC30A10 SLC39A8	1.45e-05	3	77	2	34924116
Pubmed	The distribution of theta-class glutathione S-transferases in the liver and lung of mouse, rat and human.	GSTT2 GSTT2B	1.45e-05	3	77	2	8761485
Pubmed	The Functions of ZIP8, ZIP14, and ZnT10 in the Regulation of Systemic Manganese Homeostasis.	SLC30A10 SLC39A8	1.45e-05	3	77	2	32392784
Pubmed	Specific contribution of human T-type calcium channel isotypes (alpha(1G), alpha(1H) and alpha(1I)) to neuronal excitability.	CACNA1H CACNA1G	1.45e-05	3	77	2	11927664
Pubmed	ZnT-1 enhances the activity and surface expression of T-type calcium channels through activation of Ras-ERK signaling.	CACNA1H CACNA1G	1.45e-05	3	77	2	22572848
Pubmed	Selective endocytosis of Ca2+-permeable AMPARs by the Alzheimer's disease risk factor CALM bidirectionally controls synaptic plasticity.	SNAP91 PICALM	1.45e-05	3	77	2	35613266
Pubmed	Adult loss of Cacna1a in mice recapitulates childhood absence epilepsy by distinct thalamic bursting mechanisms.	CACNA1H CACNA1G	2.89e-05	4	77	2	31800012
Pubmed	Functional importance of L- and P/Q-type voltage-gated calcium channels in human renal vasculature.	CACNA1H CACNA1G	2.89e-05	4	77	2	21788606
Pubmed	Pharmacogenetics of antiepileptic drug efficacy in childhood absence epilepsy.	CACNA1H CACNA1G	2.89e-05	4	77	2	28165634
Pubmed	Identification, characterization, and crystal structure of the Omega class glutathione transferases.	GSTT2 GSTT2B	2.89e-05	4	77	2	10783391
Pubmed	T-type Ca2+ channels elicit pro-proliferative and anti-apoptotic responses through impaired PP2A/Akt1 signaling in PASMCs from patients with pulmonary arterial hypertension.	CACNA1H CACNA1G	2.89e-05	4	77	2	28655554
Pubmed	LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.	EPHB4 TRAFD1 HGH1 BTAF1 UNC45A BAG6 TNPO3 RETREG3 NUP205 XPO7	4.31e-05	942	77	10	31073040
Pubmed	Developmental expression patterns of alpha1H T-type Ca2+ channels during spermatogenesis and organogenesis in mice.	CACNA1H CACNA1G	4.82e-05	5	77	2	12060068
Pubmed	Clathrin assembly lymphoid myeloid leukemia (CALM) protein: localization in endocytic-coated pits, interactions with clathrin, and the impact of overexpression on clathrin-mediated traffic.	SNAP91 PICALM	4.82e-05	5	77	2	10436022
Pubmed	Structure and organization of the human theta-class glutathione S-transferase and D-dopachrome tautomerase gene complex.	GSTT2 GSTT2B	4.82e-05	5	77	2	9729470
Pubmed	T-type calcium channels functionally interact with spectrin (α/β) and ankyrin B.	CACNA1H CACNA1G	4.82e-05	5	77	2	29720258
Pubmed	Role of the clathrin adaptor PICALM in normal hematopoiesis and polycythemia vera pathophysiology.	SNAP91 PICALM	4.82e-05	5	77	2	25552701
Pubmed	The solute carrier family SLC10: more than a family of bile acid transporters regarding function and phylogenetic relationships.	SLC10A5 SLC10A3	7.22e-05	6	77	2	16541252
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	ZC3H14 SYNE2 CIZ1 MACF1 BTAF1 CUL7 HERC2 BAG6 NUP205 XPO7	8.62e-05	1024	77	10	24711643
Pubmed	Enhanced expression of L-type Cav1.3 calcium channels in murine embryonic hearts from Cav1.2-deficient mice.	CACNA1H CACNA1G	1.01e-04	7	77	2	12900400
Pubmed	SARS-CoV-2 Nsp6 damages Drosophila heart and mouse cardiomyocytes through MGA/MAX complex-mediated increased glycolysis.	TRAFD1 BTAF1 UNC45A HERC2 BAG6 TNPO3 RETREG3 XPO7	1.04e-04	657	77	8	36180527
Pubmed	Evolutionary insights into T-type Ca2+ channel structure, function, and ion selectivity from the Trichoplax adhaerens homologue.	CACNA1H CACNA1G	1.34e-04	8	77	2	28330839
Pubmed	Neuroepithelial progenitors generate and propagate non-neuronal action potentials across the spinal cord.	CACNA1H CACNA1G	1.34e-04	8	77	2	34478646
Pubmed	Intracellular calcium plays an essential role in cardiac development.	CACNA1H CACNA1G	1.34e-04	8	77	2	12761855
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	SYNE2 MACF1 TOGARAM1 CACNA1G CHD7	1.47e-04	225	77	5	12168954
Pubmed	A genome-wide association study of serum uric acid in African Americans.	ARID1B SLC2A9	1.72e-04	9	77	2	21294900
Pubmed	Loss of the proteostasis factor AIRAPL causes myeloid transformation by deregulating IGF-1 signaling.	HERC2 BAG6	1.72e-04	9	77	2	26692333
Pubmed	International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels.	CACNA1H CACNA1G	1.72e-04	9	77	2	16382099
Pubmed	Expanding the Interactome of TES by Exploiting TES Modules with Different Subcellular Localizations.	TRAFD1 HGH1 MACF1 UNC45A BAG6	1.79e-04	235	77	5	28378594
Pubmed	Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism.	EPHB4 ZC3H14 ASL UGP2 CIZ1 ARMCX6 SLC10A3 PICALM DNAH14	2.05e-04	925	77	9	28986522
Pubmed	Cav3.2 T-type calcium channel is required for the NFAT-dependent Sox9 expression in tracheal cartilage.	CACNA1H CACNA1G	2.15e-04	10	77	2	24778262
Pubmed	The Eutherian Armcx genes regulate mitochondrial trafficking in neurons and interact with Miro and Trak2.	ARMCX6 TRAK2	2.63e-04	11	77	2	22569362
Pubmed	Fine genetic and comparative mapping of the deafness mutation Ames waltzer on mouse chromosome 10.	GSTT2 GSTT2B	2.63e-04	11	77	2	9653653
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	MROH1 MACF1 CACNA1H TRAK2 FAIM2 XPO7	2.91e-04	407	77	6	12693553
Pubmed	Arid1a regulates bladder urothelium formation and maintenance.	ARID1B KRT20	3.15e-04	12	77	2	35283102
Pubmed	BRCA1 is a component of the RNA polymerase II holoenzyme.	GTF2H4 BTAF1	3.15e-04	12	77	2	9159119
Pubmed	A high-throughput approach for measuring temporal changes in the interactome.	PPP1R7 HGH1 TSR1 ASL UGP2 MACF1 UNC45A BAG6 TNPO3 NUP205 XPO7	3.50e-04	1455	77	11	22863883
Pubmed	The intracellular domain of teneurin-1 induces the activity of microphthalmia-associated transcription factor (MITF) by binding to transcriptional repressor HINT1.	MACF1 PICALM	3.71e-04	13	77	2	25648896
Pubmed	Loss of the placental iron exporter ferroportin 1 causes embryonic demise in late-gestation mouse pregnancy.	SLC11A2 SLC39A8	4.33e-04	14	77	2	36398730
Pubmed	Interactome analysis reveals that lncRNA HULC promotes aerobic glycolysis through LDHA and PKM2.	TSR1 BAG6 CARD14 RETREG3	4.60e-04	161	77	4	32572027
Pubmed	A protein interaction landscape of breast cancer.	ARID1B FADD MACF1 CUL7 PICALM TNPO3 XPO7	5.16e-04	634	77	7	34591612
Pubmed	Large-scale mapping of human protein-protein interactions by mass spectrometry.	PPP1R7 TSR1 UGP2 CDK11B UNC45A HERC2 BAG6 TNPO3 NUP205 XPO7	5.27e-04	1284	77	10	17353931
Pubmed	Calcium handling precedes cardiac differentiation to initiate the first heartbeat.	CACNA1H CACNA1G	6.44e-04	17	77	2	27725084
Pubmed	A Cas9 Ribonucleoprotein Platform for Functional Genetic Studies of HIV-Host Interactions in Primary Human T Cells.	UNC45A TNPO3	6.44e-04	17	77	2	27783955
Pubmed	Defective transcription initiation causes postnatal growth failure in a mouse model of nucleotide excision repair (NER) progeria.	GSTT2 GTF2H4 GSTT2B	6.53e-04	76	77	3	22323595
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	CCDC142 EPHB4 MROH1 MFHAS1 CACNA1H SLC10A3 BTAF1 HERC2 TNPO3	7.43e-04	1105	77	9	35748872
Pubmed	Protein interactome mining defines melatonin MT1 receptors as integral component of presynaptic protein complexes of neurons.	SYNE2 ASAP3 MACF1 CUL7 BAG6	7.56e-04	322	77	5	26514267
Pubmed	Comparative analysis of apoptosis and inflammation genes of mice and humans.	FADD CUL7 BAG6	7.58e-04	80	77	3	12819136
Pubmed	A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.	PPP1R7 ARID1B CTTNBP2 SYNE2 UGP2 MACF1	8.32e-04	497	77	6	23414517
Pubmed	The protein interaction landscape of the human CMGC kinase group.	GTF2H4 TRAFD1 CACNA1H CUL7 HERC2 BAG6 TNPO3	8.85e-04	695	77	7	23602568
Pubmed	Analysis of interaction partners for eukaryotic translation elongation factor 1A M-domain by functional proteomics.	MACF1 UNC45A	8.96e-04	20	77	2	21689717
Pubmed	Cytosolic quality control of mislocalized proteins requires RNF126 recruitment to Bag6.	TRAFD1 BAG6	1.09e-03	22	77	2	24981174
Pubmed	Scanning the human proteome for calmodulin-binding proteins.	CCDC14 SYNE2 HERC2	1.14e-03	92	77	3	15840729
Pubmed	A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.	TRAFD1 SYNE2 VPS35L BTAF1 UNC45A BAG6 PICALM TNPO3 RETREG3 NUP205	1.26e-03	1440	77	10	30833792
Pubmed	The deubiquitinase TRABID stabilizes the K29/K48-specific E3 ubiquitin ligase HECTD1.	CTTNBP2 CUL7 HERC2 BAG6	1.28e-03	212	77	4	33853758
Pubmed	A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways.	PPP1R7 HGH1 SYNE2 UNC45A BAG6	1.29e-03	363	77	5	25036637
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	PPP1R7 CTTNBP2 SNAP91 SYNE2 MACF1 CHD7 HERC2 PICALM	1.31e-03	963	77	8	28671696
Pubmed	The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.	ARID1B ZNF773 GTF2H4 VPS35L BAG6 TNPO3 RETREG3 NUP205 XPO7	1.35e-03	1203	77	9	29180619
GeneFamily	Calcium voltage-gated channel subunits	CACNA1H CACNA1G CACNA2D3	5.25e-05	26	51	3	253
GeneFamily	Solute carriers	SLC11A2 SLC2A9 SLC10A5 SLC10A3 SLC30A10 SLC39A8	8.22e-04	395	51	6	752
GeneFamily	Glutathione S-transferases	GSTT2 GSTT2B	2.25e-03	25	51	2	567
Coexpression	HALLMARK_HEME_METABOLISM	SLC11A2 MFHAS1 SLC10A3 TRAK2 SLC30A10 PICALM XPO7	1.90e-06	200	76	7	M5945
Coexpression	CHYLA_CBFA2T3_TARGETS_DN	GTF2H4 SLC11A2 MFHAS1 GPSM2 TRAK2 SLC30A10 SLC39A8	7.42e-06	246	76	7	M2206
Coexpression	CHYLA_CBFA2T3_TARGETS_DN	GTF2H4 SLC11A2 MFHAS1 GPSM2 TRAK2 SLC30A10 SLC39A8	1.15e-05	263	76	7	MM1295
Coexpression	GSE3982_EOSINOPHIL_VS_TH2_DN	HGH1 MFHAS1 CIZ1 GPSM2 NUP205 XPO7	2.43e-05	198	76	6	M5425
Coexpression	NAKAYA_PLASMACYTOID_DENDRITIC_CELL_FLUMIST_AGE_18_50YO_7DY_UP	ZC3H14 LMF1 SLC11A2 GRHPR TSR1 SYNE2 CARF CIZ1 GATB MACF1 BTAF1 BAG6 SMIM7	4.30e-05	1215	76	13	M41122
Disease	Charcot-Marie-Tooth disease (biomarker_via_orthology)	GSTT2 GSTT2B	6.20e-06	2	74	2	DOID:10595 (biomarker_via_orthology)
Disease	cholesteryl esters:total lipids ratio, intermediate density lipoprotein measurement	LMF1 TOMM40L SYNE2 MACF1 SLC39A8	6.25e-06	103	74	5	EFO_0008595, EFO_0020944
Disease	phospholipids:total lipids ratio, intermediate density lipoprotein measurement	LMF1 TOMM40L MACF1 SLC39A8	2.48e-05	67	74	4	EFO_0008595, EFO_0020946
Disease	cholesterol:total lipids ratio, intermediate density lipoprotein measurement	LMF1 SYNE2 MACF1 SLC39A8	2.48e-04	121	74	4	EFO_0008595, EFO_0020943
Disease	white matter integrity	CTTNBP2 CARF BAG6 SLC39A8	3.26e-04	130	74	4	EFO_0004641
Disease	body mass index, osteoarthritis	CARF CACNA1H SLC39A8	3.43e-04	54	74	3	EFO_0004340, MONDO_0005178
Disease	3-formylindole measurement	GSTT2 GSTT2B	4.75e-04	13	74	2	EFO_0801025
Disease	Manganese Poisoning	SLC30A10 SLC39A8	5.54e-04	14	74	2	C0677050
Disease	triglycerides:total lipids ratio, low density lipoprotein cholesterol measurement	MFHAS1 SYNE2 MACF1 SLC39A8	5.60e-04	150	74	4	EFO_0004611, EFO_0020947
Disease	low density lipoprotein cholesterol measurement, phospholipids:total lipids ratio	LMF1 TOMM40L MFHAS1 ASAP3	6.03e-04	153	74	4	EFO_0004611, EFO_0020946
Disease	liver fat measurement, liver disease biomarker	SLC30A10 SLC39A8	7.28e-04	16	74	2	EFO_0006845, EFO_0010821
Disease	Dystonia, Limb	CIZ1 SLC30A10	8.24e-04	17	74	2	C0751093
Disease	Dystonia, Diurnal	CIZ1 SLC30A10	8.24e-04	17	74	2	C0393610
Disease	Alzheimer disease, psychotic symptoms	SLC2A9 PICALM	8.24e-04	17	74	2	EFO_0005940, MONDO_0004975
Disease	very low density lipoprotein cholesterol measurement, phospholipids:total lipids ratio	TOMM40L MFHAS1 SYNE2 MACF1 SLC39A8	8.33e-04	291	74	5	EFO_0008317, EFO_0020946
Disease	Dystonia, Paroxysmal	CIZ1 SLC30A10	9.25e-04	18	74	2	C0393588
Disease	low density lipoprotein cholesterol measurement, free cholesterol:total lipids ratio	MFHAS1 SYNE2 MACF1 SLC39A8	1.63e-03	200	74	4	EFO_0004611, EFO_0020945
Disease	very low density lipoprotein cholesterol measurement, cholesterol:total lipids ratio	MFHAS1 SYNE2 MACF1 SLC39A8	2.38e-03	222	74	4	EFO_0008317, EFO_0020943

Protein segments in the cluster

Peptide	Gene	Start	Entry
LLLALNMGNTSFNEV	ASAP3	491	Q8TDY4
SMADLQFSQLLGNLL	BAG6	601	P46379
LDLAGNNLTAFLAEM	ACTL9	221	Q8TC94
NNLTAFLAEMLLQAG	ACTL9	226	Q8TC94
LILQALGTSQANMAE	GATB	241	O75879
TLLMLSIFQQLDGAL	CCDC142	631	Q17RM4
SMALLSNLAQGDALA	ARID1B	2201	Q8NFD5
NELTNGVINAAFMLL	SNAP91	186	O60641
LLSDQGFDLMNKFLT	CDK11B	691	P21127
NLELFSLQSLNMSLQ	CCDC14	521	Q49A88
LQNLQSLQLAGLMGF	CHD7	2761	Q9P2D1
NSFLQQAGLNLLISM	ARMCX6	211	Q7L4S7
LALLDLNASGTMSIQ	CAPN14	566	A8MX76
NGSLDAVNLALLMAL	NUP205	261	Q92621
NNTNVADFILMGLTL	OR8H2	6	Q8N162
LNLSDLQMVLGLSYS	GPSM2	366	P81274
TLFLALDTQLLMGNR	FAIM2	266	Q9BWQ8
LAFQDQGACMALLSL	EPHB4	176	P54760
SLESLMLDNNGLQAL	MFHAS1	251	Q9Y4C4
TLAQAANFLNMLLQA	GPR179	101	Q6PRD1
ALNNLPALQAMTLAL	LGR6	181	Q9HBX8
SMLTLQHGANNLDLL	HERC2	1791	O95714
NLDLLLNSGMLALTQ	HERC2	1801	O95714
LRAELNFGAITLNSM	ASL	216	P04424
DTIGSAVMNNNSLLL	CARF	596	Q8N187
VGVQNSLLALAMLQL	SLC10A3	421	P09131
SLLAFSGLSADMLNQ	CUL7	1486	Q14999
ALLFSGQFMDALQAL	MACF1	2786	O94854
TGMNDFLNVLQSLQL	SLC11A2	436	P49281
NSNVANDLMLLDSLL	MROH1	1351	Q8NDA8
FLAGQQVTLADLMAL	GSTT2B	156	P0CG30
ANLQSLLSSLEAQLM	KRT20	326	P35900
NLTFLDLSSNQLMRL	LRIT1	156	Q9P2V4
DTFTLELLMISNNGL	OR4D9	191	Q8NGE8
LSQVTMLAFQGDALL	CARD14	566	Q9BXL6
LQSMGTDQLLDLFTL	BTAF1	1786	O14981
NLGQALMSLFVLASK	CACNA1G	1471	O43497
GMLDIALNEAFNILS	CACNA2D3	336	Q8IZS8
QAAAQGNVTLLSMLL	CTTNBP2	716	Q8WZ74
LIFSDGLQSESNIML	COL6A5	1306	A8TX70
FLAGQQVTLADLMAL	GSTT2	156	P0CG29
TRNTMSLLAANNLLA	GRHPR	301	Q9UBQ7
SGLDLFSMLLEQNDL	FADD	41	Q13158
LMNTAVTLLLELFNG	DNAH14	441	Q0VDD8
LENNARLLMLSGNNI	FBXO47	321	Q5MNV8
LLANNGFAISAALLM	SLC2A9	141	Q9NRM0
NFDNLGQALMSLFVL	CACNA1H	1486	O95180
NLSNLHQLQMLELGS	PPP1R7	181	Q15435
MQLNNNVTEFILLGL	OR4C16	1	Q8NGL9
ALLAGQAALLQALME	HGH1	56	Q9BTY7
ALAANLMNSGVRLNA	HPGD	166	P15428
SDSAMLQAQQLLLGL	CARS2	356	Q9HA77
ESANLDFMLALSLQN	TRAFD1	236	O14545
GLSMLIDSQNNQYIL	TMCO3	241	Q6UWJ1
LANISMSGNNLAEIL	SYNE2	5411	Q8WXH0
SLNELSMAGNRLAFL	LRRC28	181	Q86X40
MVSSAQLDFNLQALL	NLRP2B	1	P0DMW2
LLFGTLLMNAGAVLN	SMIM7	6	Q9BQ49
ESGMLNSFLALAVIQ	SLC10A5	371	Q5PT55
SASLLNGSMLQRALL	CIZ1	76	Q9ULV3
VSQDLAQLLSQAGLM	GTF2H4	171	Q92759
NLASLVSQGMIQLAL	RETREG3	396	Q86VR2
NELTNGVINAAFMLL	PICALM	186	Q13492
AQMQSEALSLLSNLA	PEX11G	176	Q96HA9
FSLSQGLLQLEMLQE	TRAK2	201	O60296
LGNSIALLSDSFNML	SLC30A10	31	Q6XR72
LLLVMSNLYSLNAGS	UGP2	401	Q16851
VHLNELGNTQNFMLL	TSR1	111	Q2NL82
LGNNALLLNSVMSAF	VPS35L	421	Q7Z3J2
LGVLDSNFMANNKLL	TNPO3	211	Q9Y5L0
RNVMLENFTLLASLG	ZNF773	41	Q6PK81
MDSSGSLNAQVLLLL	TOMM40L	101	Q969M1
NLNDESQHGLLMQLL	XPO7	206	Q9UIA9
LNAGMSTRQALLFNF	SLC39A8	356	Q9C0K1
LSKALFAQMGQNLLN	TOGARAM1	1681	Q9Y4F4
ELALAGINMLLNNGF	TTC39C	31	Q8N584
QMTEDLSLFLGNNTI	ZC3H14	46	Q6PJT7
SGLQNFEALMALTNL	UNC45A	746	Q9H3U1
DMNSNLDLLALLGLG	LMF1	121	Q96S06