Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	mRNA cleavage factor complex	SCAF8 SYMPK	4.83e-04	31	22	2	GO:0005849
MousePheno	abnormal hepatic diverticulum morphology	BMP4 NCOA6	3.00e-05	8	15	2	MP:0012234
MousePheno	abnormal liver bud morphology	BMP4 NCOA6	3.00e-05	8	15	2	MP:0012235
MousePheno	abnormal lateral plate mesoderm morphology	BMP4 CLUAP1	5.88e-05	11	15	2	MP:0010117
MousePheno	embryonic lethality during organogenesis, incomplete penetrance	DYRK1A BMP4 NCOA6 CLUAP1	1.53e-04	268	15	4	MP:0011108
Domain	Ubiquilin-1/2	UBQLN2 UBQLN1	1.20e-06	2	21	2	IPR028430
Domain	ARM-type_fold	IPO5 USP34 UBQLN2 XPO1 UBQLN1 SYMPK	1.47e-06	339	21	6	IPR016024
Domain	Ubiquilin	UBQLN2 UBQLN1	1.80e-05	6	21	2	IPR015496
Domain	HEAT	IPO5 XPO1 SYMPK	3.63e-05	58	21	3	IPR000357
Domain	STI1_HS-bd	UBQLN2 UBQLN1	5.39e-05	10	21	2	IPR006636
Domain	STI1	UBQLN2 UBQLN1	5.39e-05	10	21	2	SM00727
Domain	IMPORTIN_B_NT	IPO5 XPO1	1.09e-04	14	21	2	PS50166
Domain	Importin-beta_N	IPO5 XPO1	1.62e-04	17	21	2	IPR001494
Domain	6-PGluconate_DH_C-like	UBQLN2 UBQLN1	2.04e-04	19	21	2	IPR008927
Domain	UBA	UBQLN2 UBQLN1	5.14e-04	30	21	2	SM00165
Domain	UBA	UBQLN2 UBQLN1	7.41e-04	36	21	2	PF00627
Domain	UBIQUITIN_1	UBQLN2 UBQLN1	7.83e-04	37	21	2	PS00299
Domain	UBQ	UBQLN2 UBQLN1	1.06e-03	43	21	2	SM00213
Domain	UBA	UBQLN2 UBQLN1	1.11e-03	44	21	2	IPR015940
Domain	ubiquitin	UBQLN2 UBQLN1	1.26e-03	47	21	2	PF00240
Domain	UBA	UBQLN2 UBQLN1	1.26e-03	47	21	2	PS50030
Domain	HEAT	IPO5 SYMPK	1.32e-03	48	21	2	PF02985
Domain	UBIQUITIN_2	UBQLN2 UBQLN1	1.66e-03	54	21	2	PS50053
Domain	-	IPO5 XPO1 SYMPK	1.88e-03	222	21	3	1.25.10.10
Domain	Ubiquitin_dom	UBQLN2 UBQLN1	1.92e-03	58	21	2	IPR000626
Domain	UBA-like	UBQLN2 UBQLN1	2.33e-03	64	21	2	IPR009060
Domain	HEAT_REPEAT	IPO5 XPO1	2.78e-03	70	21	2	PS50077
Domain	ARM-like	IPO5 XPO1 SYMPK	3.28e-03	270	21	3	IPR011989
Domain	Ubiquitin-rel_dom	UBQLN2 UBQLN1	1.79e-02	184	21	2	IPR029071
Pubmed	A new Drosophila model of Ubiquilin knockdown shows the effect of impaired proteostasis on locomotive and learning abilities.	UBQLN2 UBQLN1	3.82e-07	2	22	2	29247619
Pubmed	Towards a molecular understanding of the overlapping and distinct roles of UBQLN1 and UBQLN2 in lung cancer progression and metastasis.	UBQLN2 UBQLN1	3.82e-07	2	22	2	35063704
Pubmed	Ubiquilin functions in autophagy and is degraded by chaperone-mediated autophagy.	UBQLN2 UBQLN1	1.15e-06	3	22	2	20529957
Pubmed	NMDAR signaling facilitates the IPO5-mediated nuclear import of CPEB3.	IPO5 XPO1	1.15e-06	3	22	2	22730302
Pubmed	Ubiquitin receptor proteins hHR23a and hPLIC2 interact.	UBQLN2 UBQLN1	1.15e-06	3	22	2	17098253
Pubmed	Nuclear export of ubiquitinated proteins via the UBIN-POST system.	UBQLN2 XPO1 UBQLN1	1.83e-06	38	22	3	29666234
Pubmed	PLIC proteins or ubiquilins regulate autophagy-dependent cell survival during nutrient starvation.	UBQLN2 UBQLN1	2.29e-06	4	22	2	19148225
Pubmed	UBQLN2 undergoes a reversible temperature-induced conformational switch that regulates binding with HSPA1B: ALS/FTD mutations cripple the switch but do not destroy HSPA1B binding.	UBQLN2 UBQLN1	2.29e-06	4	22	2	36423739
Pubmed	E6AP AZUL interaction with UBQLN1/2 in cells, condensates, and an AlphaFold-NMR integrated structure.	UBQLN2 UBQLN1	2.29e-06	4	22	2	36827983
Pubmed	Dimerization of ubiquilin is dependent upon the central region of the protein: evidence that the monomer, but not the dimer, is involved in binding presenilins.	UBQLN2 UBQLN1	2.29e-06	4	22	2	16813565
Pubmed	Herp enhances ER-associated protein degradation by recruiting ubiquilins.	UBQLN2 UBQLN1	2.29e-06	4	22	2	18307982
Pubmed	Ubiquilin regulates presenilin endoproteolysis and modulates gamma-secretase components, Pen-2 and nicastrin.	UBQLN2 UBQLN1	3.82e-06	5	22	2	15975090
Pubmed	Ubiquitin-related proteins regulate interaction of vimentin intermediate filaments with the plasma membrane.	UBQLN2 UBQLN1	3.82e-06	5	22	2	10549293
Pubmed	Structural studies of the interaction between ubiquitin family proteins and proteasome subunit S5a.	UBQLN2 UBQLN1	3.82e-06	5	22	2	11827521
Pubmed	RTL8 promotes nuclear localization of UBQLN2 to subnuclear compartments associated with protein quality control.	UBQLN2 UBQLN1	5.72e-06	6	22	2	35247097
Pubmed	The hPLIC proteins may provide a link between the ubiquitination machinery and the proteasome.	UBQLN2 UBQLN1	8.01e-06	7	22	2	10983987
Pubmed	Unbiased screen reveals ubiquilin-1 and -2 highly associated with huntingtin inclusions.	UBQLN2 UBQLN1	8.01e-06	7	22	2	23774650
Pubmed	Ubiquilins Chaperone and Triage Mitochondrial Membrane Proteins for Degradation.	UBQLN2 UBQLN1	8.01e-06	7	22	2	27345149
Pubmed	Cross-species divergence of the major recognition pathways of ubiquitylated substrates for ubiquitin/26S proteasome-mediated proteolysis.	UBQLN2 UBQLN1	8.01e-06	7	22	2	20059542
Pubmed	The ubiquitin-like protein PLIC-2 is a negative regulator of G protein-coupled receptor endocytosis.	UBQLN2 UBQLN1	8.01e-06	7	22	2	18199683
Pubmed	Structure of hRpn10 Bound to UBQLN2 UBL Illustrates Basis for Complementarity between Shuttle Factors and Substrates at the Proteasome.	UBQLN2 UBQLN1	8.01e-06	7	22	2	30664872
Pubmed	Highly homologous HERC proteins localize to endosomes and exhibit specific interactions with hPLIC and Nm23B.	UBQLN2 UBQLN1	8.01e-06	7	22	2	18535780
Pubmed	TRIM33 drives prostate tumor growth by stabilizing androgen receptor from Skp2-mediated degradation.	USP34 ZFHX3 XPO1 SYMPK	1.04e-05	220	22	4	35785414
Pubmed	Transportin 1 is a major nuclear import receptor of the nitric oxide synthase interacting protein.	IPO5 XPO1	1.07e-05	8	22	2	36690276
Pubmed	Ubiquilin4 is an adaptor protein that recruits Ubiquilin1 to the autophagy machinery.	UBQLN2 UBQLN1	1.07e-05	8	22	2	23459205
Pubmed	Changing expression and subcellular distribution of karyopherins during murine oogenesis.	IPO5 XPO1	1.37e-05	9	22	2	26399853
Pubmed	Exportin 4: a mediator of a novel nuclear export pathway in higher eukaryotes.	IPO5 XPO1	1.71e-05	10	22	2	10944119
Pubmed	PAQR9 Modulates BAG6-mediated protein quality control of mislocalized membrane proteins.	UBQLN2 UBQLN1	2.51e-05	12	22	2	31904842
Pubmed	UBQLN2 Mediates Autophagy-Independent Protein Aggregate Clearance by the Proteasome.	UBQLN2 UBQLN1	2.97e-05	13	22	2	27477512
Pubmed	Huntingtin: an iron-regulated protein essential for normal nuclear and perinuclear organelles.	XPO1 SYMPK	3.99e-05	15	22	2	11092755
Pubmed	A systematic survey of carbonic anhydrase mRNA expression during mammalian inner ear development.	BMP4 CA5A	8.76e-05	22	22	2	23233153
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	FBXO38 SCAF8 NCOA6 XPO1 SYMPK	1.04e-04	774	22	5	15302935
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	DYRK1A IPO5 USP34 TMEM59 UBQLN2 UBQLN1	1.13e-04	1285	22	6	35914814
Pubmed	Characterization of carbonic anhydrase IX interactome reveals proteins assisting its nuclear localization in hypoxic cells.	IPO5 XPO1	1.23e-04	26	22	2	23181366
Pubmed	Comparative Application of BioID and TurboID for Protein-Proximity Biotinylation.	USP34 BCL9L SCAF8 NCOA6	1.78e-04	457	22	4	32344865
Pubmed	Regulated endoplasmic reticulum-associated degradation of a polytopic protein: p97 recruits proteasomes to Insig-1 before extraction from membranes.	UBQLN2 UBQLN1	1.87e-04	32	22	2	19815544
Pubmed	An inducible CRISPR/Cas9 screen identifies DTX2 as a transcriptional regulator of human telomerase.	USP34 BCL9L SCAF8	1.95e-04	180	22	3	35198878
Pubmed	Wnt signalling regulates paxillin ubiquitination essential for mesodermal cell motility.	UBQLN2 UBQLN1	1.99e-04	33	22	2	17558393
Pubmed	Genome-wide association scan of dental caries in the permanent dentition.	BMP4 PLPPR5	1.99e-04	33	22	2	23259602
Pubmed	The CARM1-p300-c-Myc-Max (CPCM) transcriptional complex regulates the expression of CUL4A/4B and affects the stability of CRL4 E3 ligases in colorectal cancer.	USP34 XPO1	1.99e-04	33	22	2	32140074
Pubmed	Downregulation of HERC5 E3 ligase attenuates the ubiquitination of CtBP1 to inhibit apoptosis in colorectal cancer cells.	USP34 XPO1	2.51e-04	37	22	2	34147029
Pubmed	LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.	TMEM59 UBQLN2 XPO1 UBQLN1 SYMPK	2.59e-04	942	22	5	31073040
Pubmed	DDI2 protease controls embryonic development and inflammation via TCF11/NRF1.	UBQLN2 UBQLN1	2.94e-04	40	22	2	39328932
Pubmed	Phase-separated nuclear bodies of nucleoporin fusions promote condensation of MLL1/CRM1 and rearrangement of 3D genome structure.	IPO5 XPO1	2.94e-04	40	22	2	37516964
Pubmed	Quality Control of ER Membrane Proteins by the RNF185/Membralin Ubiquitin Ligase Complex.	IPO5 XPO1	3.24e-04	42	22	2	32738194
Pubmed	Quantitative Proteomics of the SMAD (Suppressor of Mothers against Decapentaplegic) Transcription Factor Family Identifies Importin 5 as a Bone Morphogenic Protein Receptor SMAD-specific Importin.	IPO5 NCOA6	4.23e-04	48	22	2	27703004
Pubmed	Crosstalk between Lys63- and Lys11-polyubiquitin signaling at DNA damage sites is driven by Cezanne.	UBQLN2 UBQLN1	4.59e-04	50	22	2	31699778
Pubmed	Functional proteomics mapping of a human signaling pathway.	BMP4 NCOA6 UBQLN2 UBQLN1	4.73e-04	591	22	4	15231748
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	DYRK1A USP34 BMP4 NCOA6 SYMPK	5.38e-04	1105	22	5	35748872
Pubmed	The p97/VCP segregase is essential for arsenic-induced degradation of PML and PML-RARA.	IPO5 USP34 SYMPK	5.85e-04	262	22	3	36880596
Pubmed	Subtypes of medulloblastoma have distinct developmental origins.	BMP4 ZFHX3	5.97e-04	57	22	2	21150899
Interaction	PLAAT2 interactions	SCAF8 UBQLN2 UBQLN1	2.38e-07	13	20	3	int:PLAAT2
Interaction	NUP35 interactions	DYRK1A USP34 BCL9L SCAF8 NCOA6 XPO1	2.53e-06	424	20	6	int:NUP35
Interaction	SMIM2 interactions	UBQLN2 UBQLN1	2.81e-06	3	20	2	int:SMIM2
Interaction	DEFB115 interactions	UBQLN2 UBQLN1	2.81e-06	3	20	2	int:DEFB115
Interaction	CSTF2T interactions	UBQLN2 XPO1 UBQLN1 SYMPK	3.16e-06	105	20	4	int:CSTF2T
Interaction	GUCA2B interactions	UBQLN2 UBQLN1	9.34e-06	5	20	2	int:GUCA2B
Interaction	RTL8C interactions	CLUAP1 UBQLN2 UBQLN1	1.32e-05	47	20	3	int:RTL8C
Interaction	C1QTNF4 interactions	UBQLN2 UBQLN1	1.40e-05	6	20	2	int:C1QTNF4
Interaction	USP34 interactions	DYRK1A USP34 UBQLN2 UBQLN1	1.56e-05	157	20	4	int:USP34
Interaction	CSTF2 interactions	UBQLN2 XPO1 UBQLN1 SYMPK	1.90e-05	165	20	4	int:CSTF2
Interaction	SMIM19 interactions	UBQLN2 UBQLN1	1.96e-05	7	20	2	int:SMIM19
Interaction	GPR162 interactions	UBQLN2 UBQLN1	2.61e-05	8	20	2	int:GPR162
Interaction	WFDC12 interactions	UBQLN2 UBQLN1	2.61e-05	8	20	2	int:WFDC12
Interaction	C1QTNF2 interactions	UBQLN2 UBQLN1 SELENOO	3.05e-05	62	20	3	int:C1QTNF2
Interaction	DESI1 interactions	UBQLN2 XPO1 UBQLN1	3.51e-05	65	20	3	int:DESI1
Interaction	UBL7 interactions	USP34 UBQLN2 UBQLN1	3.84e-05	67	20	3	int:UBL7
Interaction	ZC3H12C interactions	UBQLN2 XPO1	4.19e-05	10	20	2	int:ZC3H12C
Interaction	SEZ6L interactions	UBQLN2 UBQLN1	5.12e-05	11	20	2	int:SEZ6L
Interaction	RTL8A interactions	UBQLN2 UBQLN1	5.12e-05	11	20	2	int:RTL8A
Interaction	PAQR9 interactions	UBQLN2 UBQLN1	5.12e-05	11	20	2	int:PAQR9
Interaction	PLAAT3 interactions	UBQLN2 UBQLN1	5.12e-05	11	20	2	int:PLAAT3
Interaction	YAP1 interactions	IPO5 BCL9L NCOA6 UBQLN2 XPO1 UBQLN1 SYMPK	5.69e-05	1095	20	7	int:YAP1
Interaction	EPS15 interactions	DYRK1A UBQLN2 XPO1 UBQLN1	5.84e-05	220	20	4	int:EPS15
Interaction	ZG16 interactions	UBQLN2 UBQLN1	6.14e-05	12	20	2	int:ZG16
Interaction	RTL8B interactions	UBQLN2 UBQLN1	7.25e-05	13	20	2	int:RTL8B
Interaction	SOD3 interactions	UBQLN2 UBQLN1	7.25e-05	13	20	2	int:SOD3
Interaction	CLU interactions	DYRK1A BMP4 CLUAP1 XPO1	8.86e-05	245	20	4	int:CLU
Interaction	SNAP29 interactions	CLUAP1 UBQLN2 XPO1 UBQLN1	9.00e-05	246	20	4	int:SNAP29
Interaction	NUP58 interactions	UBQLN2 XPO1 UBQLN1	9.92e-05	92	20	3	int:NUP58
Interaction	CEP55 interactions	DYRK1A CLUAP1 UBQLN2 XPO1	1.05e-04	256	20	4	int:CEP55
Interaction	GUCA2A interactions	UBQLN2 UBQLN1	1.11e-04	16	20	2	int:GUCA2A
Interaction	DYNLL2 interactions	DYRK1A FBXO38 NCOA6 UBQLN1	1.16e-04	263	20	4	int:DYNLL2
Interaction	UBXN7 interactions	FBXO38 USP34 UBQLN2 UBQLN1	1.23e-04	267	20	4	int:UBXN7
Interaction	IL20 interactions	BMP4 TMEM59	1.26e-04	17	20	2	int:IL20
Interaction	COL9A2 interactions	UBQLN2 UBQLN1	1.26e-04	17	20	2	int:COL9A2
Interaction	NPY interactions	UBQLN2 UBQLN1	1.42e-04	18	20	2	int:NPY
Interaction	SERPINI2 interactions	UBQLN2 UBQLN1	1.42e-04	18	20	2	int:SERPINI2
Interaction	PRAP1 interactions	UBQLN2 UBQLN1	1.42e-04	18	20	2	int:PRAP1
Interaction	FAM53B interactions	DYRK1A XPO1	1.42e-04	18	20	2	int:FAM53B
Interaction	SHROOM1 interactions	DYRK1A XPO1	1.42e-04	18	20	2	int:SHROOM1
Interaction	NBL1 interactions	UBQLN2 UBQLN1	1.42e-04	18	20	2	int:NBL1
Interaction	CDIP1 interactions	UBQLN2 UBQLN1	1.42e-04	18	20	2	int:CDIP1
Interaction	CSN3 interactions	UBQLN2 UBQLN1	1.58e-04	19	20	2	int:CSN3
Interaction	SRGN interactions	UBQLN2 UBQLN1	1.76e-04	20	20	2	int:SRGN
Interaction	SUGT1 interactions	IPO5 FBXO38 CLUAP1 SYMPK	1.76e-04	293	20	4	int:SUGT1
Interaction	CTAG1B interactions	USP34 UBQLN2 UBQLN1	1.83e-04	113	20	3	int:CTAG1B
Interaction	PIK3IP1 interactions	UBQLN2 UBQLN1	1.94e-04	21	20	2	int:PIK3IP1
Interaction	KHNYN interactions	UBQLN2 XPO1	1.94e-04	21	20	2	int:KHNYN
Interaction	CORT interactions	BMP4 TMEM59	1.94e-04	21	20	2	int:CORT
Interaction	SMR3B interactions	UBQLN2 UBQLN1	2.14e-04	22	20	2	int:SMR3B
Interaction	CCL7 interactions	UBQLN2 UBQLN1	2.14e-04	22	20	2	int:CCL7
Interaction	AGFG2 interactions	UBQLN2 XPO1	2.14e-04	22	20	2	int:AGFG2
Interaction	GLCCI1 interactions	DYRK1A XPO1	2.34e-04	23	20	2	int:GLCCI1
Interaction	DEFA6 interactions	UBQLN2 UBQLN1	2.34e-04	23	20	2	int:DEFA6
Interaction	UBE2V1 interactions	USP34 UBQLN2 UBQLN1	2.40e-04	124	20	3	int:UBE2V1
Interaction	GHRL interactions	UBQLN2 UBQLN1	2.55e-04	24	20	2	int:GHRL
Interaction	PAX9 interactions	BCL9L NCOA6 ZFHX3	2.76e-04	130	20	3	int:PAX9
Interaction	DMKN interactions	UBQLN2 UBQLN1	2.77e-04	25	20	2	int:DMKN
Interaction	ETNK1 interactions	UBQLN2 UBQLN1	2.77e-04	25	20	2	int:ETNK1
Interaction	RNF4 interactions	DYRK1A IPO5 USP34 UBQLN2 XPO1 UBQLN1 SYMPK	2.81e-04	1412	20	7	int:RNF4
Interaction	AR interactions	USP34 BCL9L NCOA6 ZFHX3 XPO1 SYMPK	2.99e-04	992	20	6	int:AR
Interaction	SCG5 interactions	UBQLN2 UBQLN1	3.00e-04	26	20	2	int:SCG5
Interaction	PPIC interactions	UBQLN2 UBQLN1	3.00e-04	26	20	2	int:PPIC
Interaction	ZMYM3 interactions	IPO5 UBQLN2 UBQLN1	3.22e-04	137	20	3	int:ZMYM3
Interaction	SLC29A2 interactions	UBQLN2 UBQLN1	3.24e-04	27	20	2	int:SLC29A2
Interaction	IFNE interactions	BMP4 TMEM59	3.24e-04	27	20	2	int:IFNE
Interaction	APOC4 interactions	UBQLN2 UBQLN1	3.24e-04	27	20	2	int:APOC4
Interaction	EPS15L1 interactions	UBQLN2 XPO1 UBQLN1	3.29e-04	138	20	3	int:EPS15L1
Interaction	ARPIN interactions	UBQLN2 XPO1	3.48e-04	28	20	2	int:ARPIN
Interaction	LAMB1 interactions	DYRK1A XPO1 UBQLN1	3.58e-04	142	20	3	int:LAMB1
Interaction	OR4N2 interactions	UBQLN2 UBQLN1	3.74e-04	29	20	2	int:OR4N2
Interaction	GAL interactions	UBQLN2 UBQLN1	3.74e-04	29	20	2	int:GAL
Interaction	PSORS1C2 interactions	UBQLN2 UBQLN1	3.74e-04	29	20	2	int:PSORS1C2
Interaction	TOLLIP interactions	DYRK1A TMEM59 UBQLN2 XPO1	3.79e-04	358	20	4	int:TOLLIP
Interaction	POM121 interactions	DYRK1A IPO5 UBQLN2	3.96e-04	147	20	3	int:POM121
Interaction	STAM2 interactions	UBQLN2 XPO1 UBQLN1	3.96e-04	147	20	3	int:STAM2
Interaction	ERP27 interactions	UBQLN2 UBQLN1	4.00e-04	30	20	2	int:ERP27
Interaction	LPIN1 interactions	DYRK1A XPO1	4.28e-04	31	20	2	int:LPIN1
Interaction	MACIR interactions	IPO5 XPO1	4.28e-04	31	20	2	int:MACIR
Interaction	KNDC1 interactions	DYRK1A XPO1	4.56e-04	32	20	2	int:KNDC1
Interaction	GABARAPL1 interactions	IPO5 XPO1 SELENOO	4.80e-04	157	20	3	int:GABARAPL1
Interaction	MICOS10-NBL1 interactions	UBQLN2 UBQLN1	4.85e-04	33	20	2	int:MICOS10-NBL1
Interaction	PCDHGA9 interactions	ZFHX3 UBQLN2	4.85e-04	33	20	2	int:PCDHGA9
Interaction	GLUL interactions	DYRK1A USP34 UBQLN2	5.07e-04	160	20	3	int:GLUL
Interaction	MAP3K1 interactions	DYRK1A XPO1 UBQLN1	5.16e-04	161	20	3	int:MAP3K1
Interaction	PELO interactions	CLUAP1 UBQLN2 XPO1	5.16e-04	161	20	3	int:PELO
Interaction	UBAP1 interactions	UBQLN2 XPO1	5.46e-04	35	20	2	int:UBAP1
Interaction	MIEF2 interactions	UBQLN2 UBQLN1	5.46e-04	35	20	2	int:MIEF2
Interaction	CTAG2 interactions	UBQLN1 SELENOO	5.46e-04	35	20	2	int:CTAG2
Interaction	PPP6R1 interactions	DYRK1A UBQLN2 XPO1	5.64e-04	166	20	3	int:PPP6R1
Interaction	VPS37A interactions	UBQLN2 XPO1	5.78e-04	36	20	2	int:VPS37A
Interaction	ITGB3 interactions	IPO5 UBQLN2 XPO1	6.05e-04	170	20	3	int:ITGB3
Interaction	EDDM3A interactions	BMP4 TMEM59	6.10e-04	37	20	2	int:EDDM3A
Interaction	SLPI interactions	UBQLN2 UBQLN1	6.10e-04	37	20	2	int:SLPI
Interaction	EGR2 interactions	BCL9L NCOA6 ZFHX3	6.15e-04	171	20	3	int:EGR2
Interaction	GOLGA2 interactions	DYRK1A SCAF8 NCOA6 ZFHX3 XPO1	6.17e-04	733	20	5	int:GOLGA2
Interaction	HSPB8 interactions	DYRK1A USP34 XPO1	6.26e-04	172	20	3	int:HSPB8
Interaction	COL10A1 interactions	UBQLN2 UBQLN1	6.44e-04	38	20	2	int:COL10A1
Interaction	CD99L2 interactions	UBQLN2 UBQLN1	6.78e-04	39	20	2	int:CD99L2
Interaction	OCIAD1 interactions	IPO5 USP34 XPO1 SYMPK	6.85e-04	419	20	4	int:OCIAD1
Cytoband	2p15	USP34 C2orf74 XPO1	4.26e-07	31	22	3	2p15
Cytoband	Ensembl 112 genes in cytogenetic band chr2p15	USP34 C2orf74 XPO1	1.25e-06	44	22	3	chr2p15
GeneFamily	Ubiquilin family	UBQLN2 UBQLN1	6.42e-06	5	15	2	783
Coexpression	SHEN_SMARCA2_TARGETS_UP	SCAF8 NCOA6 TMEM59 UBQLN2 XPO1	2.40e-05	429	22	5	M29
Computational	Neighborhood of DEAF1	UBQLN2 UBQLN1	5.84e-04	28	14	2	GCM_DEAF1
Computational	Neighborhood of CSNK1D	UBQLN2 UBQLN1	7.64e-04	32	14	2	GCM_CSNK1D
Drug	NN-B	DYRK1A BMP4	5.34e-06	4	22	2	CID005278689
Drug	Trichostatin A, Streptomyces sp.; Down 200; 0.1uM; MCF7; HT_HG-U133A_EA	DYRK1A SCAF8 NCOA6 ZFHX3	1.98e-05	170	22	4	1050_DN
Drug	Trichostatin A, Streptomyces sp.; Down 200; 1uM; MCF7; HT_HG-U133A_EA	DYRK1A SCAF8 NCOA6 ZFHX3	2.07e-05	172	22	4	1072_DN
Drug	SAHA; Down 200; 10uM; MCF7; HT_HG-U133A_EA	DYRK1A SCAF8 NCOA6 ZFHX3	2.21e-05	175	22	4	1058_DN
Drug	Trichostatin A, Streptomyces sp.; Down 200; 0.1uM; MCF7; HT_HG-U133A_EA	DYRK1A SCAF8 NCOA6 ZFHX3	2.37e-05	178	22	4	1112_DN
Drug	chlorpromazine hydrochloride; Down 200; 1uM; MCF7; HT_HG-U133A	IPO5 FBXO38 USP34 ZFHX3	3.66e-05	199	22	4	6936_DN
Disease	amyotrophic lateral sclerosis type 15 (implicated_via_orthology)	UBQLN2 UBQLN1	1.45e-06	3	21	2	DOID:0060206 (implicated_via_orthology)
Disease	sex interaction measurement, Crohn's disease	USP34 C2orf74 XPO1	2.38e-06	37	21	3	EFO_0000384, EFO_0008343
Disease	frontotemporal dementia (implicated_via_orthology)	UBQLN2 UBQLN1	3.17e-05	12	21	2	DOID:9255 (implicated_via_orthology)
Disease	Paroxysmal atrial fibrillation	USP34 ZFHX3 XPO1	1.80e-04	156	21	3	C0235480
Disease	Persistent atrial fibrillation	USP34 ZFHX3 XPO1	1.80e-04	156	21	3	C2585653
Disease	familial atrial fibrillation	USP34 ZFHX3 XPO1	1.80e-04	156	21	3	C3468561
Disease	Atrial Fibrillation	USP34 ZFHX3 XPO1	1.94e-04	160	21	3	C0004238
Disease	amyotrophic lateral sclerosis (implicated_via_orthology)	UBQLN2 UBQLN1	2.07e-04	30	21	2	DOID:332 (implicated_via_orthology)
Disease	Crohn's disease	GAL3ST3 USP34 C2orf74 XPO1	2.41e-04	441	21	4	EFO_0000384
Disease	epithelial cell adhesion molecule measurement	USP34 C2orf74	6.02e-04	51	21	2	EFO_0010574
Disease	cognitive behavioural therapy	PLPPR5 ZFHX3	7.78e-04	58	21	2	EFO_0007820
Disease	colorectal cancer	BCL9L BMP4 UBQLN1 SYMPK	7.89e-04	604	21	4	MONDO_0005575
Disease	atrial fibrillation	USP34 ZFHX3 XPO1	2.22e-03	371	21	3	EFO_0000275
Disease	alpha fetoprotein measurement	DYRK1A USP34	2.29e-03	100	21	2	EFO_0010583
Disease	eosinophil measurement	DYRK1A USP34	2.66e-03	108	21	2	EFO_0803540
Disease	creatinine measurement, glomerular filtration rate	BMP4 NCOA6	3.12e-03	117	21	2	EFO_0004518, EFO_0005208
Disease	myeloid white cell count	DYRK1A USP34 ZFHX3 XPO1	3.93e-03	937	21	4	EFO_0007988
Disease	lung non-small cell carcinoma (is_implicated_in)	ZFHX3 XPO1	4.36e-03	139	21	2	DOID:3908 (is_implicated_in)
Disease	stroke	DYRK1A ZFHX3	4.67e-03	144	21	2	EFO_0000712
Disease	neurodegenerative disease (implicated_via_orthology)	UBQLN2 UBQLN1	4.74e-03	145	21	2	DOID:1289 (implicated_via_orthology)
Disease	creatinine measurement	SCAF8 BMP4 ZFHX3 CLUAP1	4.86e-03	995	21	4	EFO_0004518

Protein segments in the cluster

Peptide	Gene	Start	Entry
MRAPMLQKQQAPRMD	CCDC89	1	Q8N998
MPDIVMLQRRMPQTF	DYRK1A	71	Q13627
MIPGNRMLMVVLLCQ	BMP4	1	P12644
MDNLAQMPMISIPRV	PLPPR5	286	Q32ZL2
LPMIKEHIMQMLQNP	IPO5	356	O00410
ITMAVSRMLNLQLMP	GPRC6A	151	Q5T6X5
MLMMQQDPKSVRLPV	NCOA6	1036	Q14686
LNMDQVLDQILRMPP	FBXO38	981	Q6PIJ6
MMVNNYRPLQPLMNR	CA5A	276	P35218
MPPILQRLQQATKMM	GAL3ST3	1	Q96A11
MNMMIQRLGQDSLTP	BCL9L	501	Q86UU0
ILMQVMNLNVPMRPG	C2orf74	71	A8MZ97
LSIPNQRMPTMPMLD	SCAF8	911	Q9UPN6
PQMDPRQLSMMLMLA	SELENOO	496	Q9BVL4
RRLPKPQTAMEMLMQ	CLUAP1	331	Q96AJ1
LRQEQLMSLMPKMHL	TMEM59	126	Q9BXS4
MMQLKQMLPLNTNIR	XPO1	291	O14980
QSMLSNPDLMRQLIM	UBQLN1	196	Q9UMX0
NPDLMRQLIMANPQM	UBQLN1	201	Q9UMX0
QQLMEQSPLPMLLMR	SYMPK	986	Q92797
ELLMLLPTCPNMLMA	USP34	1396	Q70CQ2
MRQLIMANPQMQQLI	UBQLN2	201	Q9UHD9
IFSPLMMQTMPLQTL	ZFHX3	2096	Q15911
MMQTMPLQTLPAQLP	ZFHX3	2101	Q15911