Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	arachidonate 12(S)-lipoxygenase activity	ALOX12 ALOX5 ALOX15	1.31e-07	4	65	3	GO:0004052
GeneOntologyMolecularFunction	hepoxilin-epoxide hydrolase activity	ALOX12 ALOX15	1.04e-05	2	65	2	GO:0047977
GeneOntologyMolecularFunction	glucan 1,4-alpha-glucosidase activity	MGAM MGAM2	1.04e-05	2	65	2	GO:0004339
GeneOntologyMolecularFunction	linoleate 13S-lipoxygenase activity	ALOX12 ALOX15	3.12e-05	3	65	2	GO:0016165
GeneOntologyMolecularFunction	arachidonate 15-lipoxygenase activity	ALOX12 ALOX15	3.12e-05	3	65	2	GO:0050473
GeneOntologyMolecularFunction	carbohydrate binding	MGAM PLOD3 GYS1 PKD1 SIGLEC10 FUCA1 MGAM2	6.54e-05	310	65	7	GO:0030246
GeneOntologyMolecularFunction	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	ALOX12 ALOX5 ALOX15	7.19e-05	25	65	3	GO:0016702
GeneOntologyMolecularFunction	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen	ALOX12 ALOX5 ALOX15	8.11e-05	26	65	3	GO:0016701
GeneOntologyMolecularFunction	alpha-1,4-glucosidase activity	MGAM MGAM2	1.04e-04	5	65	2	GO:0004558
GeneOntologyMolecularFunction	iron ion binding	PLOD3 SCD ALOX12 ALOX5 ALOX15	2.06e-04	166	65	5	GO:0005506
GeneOntologyMolecularFunction	alpha-glucosidase activity	MGAM MGAM2	2.17e-04	7	65	2	GO:0090599
GeneOntologyMolecularFunction	dioxygenase activity	PLOD3 ALOX12 ALOX5 ALOX15	2.94e-04	98	65	4	GO:0051213
GeneOntologyMolecularFunction	epoxide hydrolase activity	ALOX12 ALOX15	5.63e-04	11	65	2	GO:0004301
GeneOntologyMolecularFunction	hydrolase activity, acting on ether bonds	ALOX12 ALOX15	7.95e-04	13	65	2	GO:0016801
GeneOntologyMolecularFunction	ether hydrolase activity	ALOX12 ALOX15	7.95e-04	13	65	2	GO:0016803
GeneOntologyMolecularFunction	glucosidase activity	MGAM MGAM2	1.07e-03	15	65	2	GO:0015926
GeneOntologyMolecularFunction	hydrolase activity, acting on glycosyl bonds	MGAM SMPDL3B FUCA1 MGAM2	1.25e-03	144	65	4	GO:0016798
GeneOntologyMolecularFunction	mechanosensitive monoatomic ion channel activity	TMC2 TMC3	1.54e-03	18	65	2	GO:0008381
GeneOntologyMolecularFunction	glucosyltransferase activity	PLOD3 GYS1	2.31e-03	22	65	2	GO:0046527
GeneOntologyMolecularFunction	oxidoreductase activity	PLOD3 DNAJC10 SCD ALOX12 ALOX5 SDHB ALOX15 STAB1	3.31e-03	766	65	8	GO:0016491
GeneOntologyBiologicalProcess	lipoxin biosynthetic process	ALOX12 ALOX5 ALOX15	1.31e-07	4	67	3	GO:2001301
GeneOntologyBiologicalProcess	lipoxin metabolic process	ALOX12 ALOX5 ALOX15	3.26e-07	5	67	3	GO:2001300
GeneOntologyBiologicalProcess	lipoxygenase pathway	ALOX12 ALOX5 ALOX15	5.31e-06	11	67	3	GO:0019372
GeneOntologyBiologicalProcess	leukotriene A4 metabolic process	ALOX12 ALOX5	1.04e-05	2	67	2	GO:1901751
GeneOntologyBiologicalProcess	lipoxin A4 biosynthetic process	ALOX12 ALOX15	3.11e-05	3	67	2	GO:2001303
GeneOntologyBiologicalProcess	detection of mechanical stimulus involved in sensory perception of sound	TMC2 STRC STRCP1	5.54e-05	23	67	3	GO:0050910
GeneOntologyBiologicalProcess	lipoxin A4 metabolic process	ALOX12 ALOX15	6.21e-05	4	67	2	GO:2001302
GeneOntologyBiologicalProcess	epoxide metabolic process	ALOX12 ALOX5	1.03e-04	5	67	2	GO:0097176
GeneOntologyBiologicalProcess	detection of mechanical stimulus	TMC2 PKD1 STRC STRCP1	1.04e-04	75	67	4	GO:0050982
GeneOntologyBiologicalProcess	long-chain fatty acid biosynthetic process	ALOX12 ALOX5 ALOX15	1.13e-04	29	67	3	GO:0042759
GeneOntologyBiologicalProcess	hepoxilin metabolic process	ALOX12 ALOX15	2.87e-04	8	67	2	GO:0051121
GeneOntologyBiologicalProcess	hepoxilin biosynthetic process	ALOX12 ALOX15	2.87e-04	8	67	2	GO:0051122
GeneOntologyBiologicalProcess	response to amphetamine	OXTR RGS9 RGS7	2.97e-04	40	67	3	GO:0001975
GeneOntologyBiologicalProcess	negative regulation of phosphorylation	HGF SLC8A1 PTPRB DNAJC10 PPP1R15B ANKLE2 DMTN	3.18e-04	401	67	7	GO:0042326
GeneOntologyBiologicalProcess	response to endoplasmic reticulum stress	DNAJC10 PIK3R2 PPP1R15B ERMP1 ALOX5 ALOX15	3.91e-04	295	67	6	GO:0034976
GeneOntologyCellularComponent	stereocilium tip	TMC2 STRC STRCP1	4.85e-05	22	68	3	GO:0032426
MousePheno	abnormal cochlear hair cell physiology	NPTN TMC2 STRC STRCP1	2.33e-05	40	59	4	MP:0004432
MousePheno	absent Z line	SLC8A1 DMPK	5.24e-05	3	59	2	MP:0004092
MousePheno	abnormal hair cell physiology	NPTN TMC2 STRC STRCP1	5.26e-05	49	59	4	MP:0003879
Domain	LH2	PKD1 ALOX12 ALOX5 ALOX15	4.46e-07	18	67	4	SM00308
Domain	PLAT	PKD1 ALOX12 ALOX5 ALOX15	8.64e-07	21	67	4	PS50095
Domain	-	PKD1 ALOX12 ALOX5 ALOX15	8.64e-07	21	67	4	2.60.60.20
Domain	PLAT	PKD1 ALOX12 ALOX5 ALOX15	8.64e-07	21	67	4	PF01477
Domain	PLAT/LH2_dom	PKD1 ALOX12 ALOX5 ALOX15	8.64e-07	21	67	4	IPR001024
Domain	LipOase_mml	ALOX12 ALOX5 ALOX15	8.76e-07	6	67	3	IPR001885
Domain	LIPOXYGENASE_1	ALOX12 ALOX5 ALOX15	8.76e-07	6	67	3	PS00711
Domain	LipOase_C	ALOX12 ALOX5 ALOX15	8.76e-07	6	67	3	IPR013819
Domain	Lipoxygenase	ALOX12 ALOX5 ALOX15	8.76e-07	6	67	3	PF00305
Domain	LIPOXYGENASE_3	ALOX12 ALOX5 ALOX15	8.76e-07	6	67	3	PS51393
Domain	LIPOXYGENASE_2	ALOX12 ALOX5 ALOX15	8.76e-07	6	67	3	PS00081
Domain	LipOase	ALOX12 ALOX5 ALOX15	8.76e-07	6	67	3	IPR000907
Domain	LipOase_Fe_BS	ALOX12 ALOX5 ALOX15	8.76e-07	6	67	3	IPR020833
Domain	LipOase_CS	ALOX12 ALOX5 ALOX15	8.76e-07	6	67	3	IPR020834
Domain	-	MGAM TMEM190 MGAM2	7.13e-06	11	67	3	4.10.110.10
Domain	P_trefoil_dom	MGAM TMEM190 MGAM2	9.49e-06	12	67	3	IPR000519
Domain	GGL	RGS6 RGS9 RGS7	2.39e-05	16	67	3	SM00224
Domain	G-gamma	RGS6 RGS9 RGS7	2.39e-05	16	67	3	PF00631
Domain	-	RGS6 RGS9 RGS7	2.39e-05	16	67	3	4.10.260.10
Domain	Gprotein-gamma	RGS6 RGS9 RGS7	2.39e-05	16	67	3	IPR001770
Domain	G_PROTEIN_GAMMA	RGS6 RGS9 RGS7	2.39e-05	16	67	3	PS50058
Domain	G-protein_gamma-like_dom	RGS6 RGS9 RGS7	2.39e-05	16	67	3	IPR015898
Domain	-	RGS6 RGS9 RGS7	6.47e-05	22	67	3	1.10.196.10
Domain	DEP	RGS6 RGS9 RGS7	6.47e-05	22	67	3	PF00610
Domain	DEP	RGS6 RGS9 RGS7	6.47e-05	22	67	3	PS50186
Domain	RGS_subdom1	RGS6 RGS9 RGS7	6.47e-05	22	67	3	IPR024066
Domain	DEP	RGS6 RGS9 RGS7	6.47e-05	22	67	3	SM00049
Domain	DEP_dom	RGS6 RGS9 RGS7	7.42e-05	23	67	3	IPR000591
Domain	NtCtMGAM_N	MGAM MGAM2	7.57e-05	4	67	2	PF16863
Domain	Gal_mutarotase_N	MGAM MGAM2	7.57e-05	4	67	2	IPR031727
Domain	Glyco_hydro_31_AS	MGAM MGAM2	1.88e-04	6	67	2	IPR030458
Domain	Glyco_hydro_31	MGAM MGAM2	2.63e-04	7	67	2	IPR000322
Domain	Glyco_hydro_31	MGAM MGAM2	2.63e-04	7	67	2	PF01055
Domain	GLYCOSYL_HYDROL_F31_1	MGAM MGAM2	2.63e-04	7	67	2	PS00129
Domain	RGS	RGS6 RGS9 RGS7	2.66e-04	35	67	3	PF00615
Domain	RGS	RGS6 RGS9 RGS7	2.66e-04	35	67	3	SM00315
Domain	RGS	RGS6 RGS9 RGS7	2.89e-04	36	67	3	PS50132
Domain	Trefoil	MGAM MGAM2	3.50e-04	8	67	2	PF00088
Domain	TMC	TMC2 TMC3	3.50e-04	8	67	2	PF07810
Domain	TMC	TMC2 TMC3	3.50e-04	8	67	2	IPR012496
Domain	RGS	RGS6 RGS9 RGS7	3.68e-04	39	67	3	IPR016137
Domain	P_TREFOIL_2	MGAM MGAM2	4.49e-04	9	67	2	PS51448
Domain	PD	MGAM MGAM2	4.49e-04	9	67	2	SM00018
Domain	CUB	CSMD2 SEZ6L2 DCBLD2	7.22e-04	49	67	3	PF00431
Domain	CUB	CSMD2 SEZ6L2 DCBLD2	7.67e-04	50	67	3	SM00042
Domain	TIL	FCGBP MUC5AC	8.18e-04	12	67	2	PF01826
Domain	C8	FCGBP MUC5AC	8.18e-04	12	67	2	PF08742
Domain	-	CSMD2 SEZ6L2 DCBLD2	8.60e-04	52	67	3	2.60.120.290
Domain	Sushi	C4BPA CSMD2 SEZ6L2	8.60e-04	52	67	3	PF00084
Domain	CUB	CSMD2 SEZ6L2 DCBLD2	9.09e-04	53	67	3	PS01180
Domain	Glycoside_hydrolase_SF	MGAM FUCA1 MGAM2	9.09e-04	53	67	3	IPR017853
Domain	CCP	C4BPA CSMD2 SEZ6L2	9.60e-04	54	67	3	SM00032
Domain	Unchr_dom_Cys-rich	FCGBP MUC5AC	9.64e-04	13	67	2	IPR014853
Domain	C8	FCGBP MUC5AC	9.64e-04	13	67	2	SM00832
Domain	SUSHI	C4BPA CSMD2 SEZ6L2	1.07e-03	56	67	3	PS50923
Domain	-	RGS6 IRF3 RECQL RGS9 RGS7	1.11e-03	218	67	5	1.10.10.10
Domain	TIL_dom	FCGBP MUC5AC	1.12e-03	14	67	2	IPR002919
Domain	Sushi_SCR_CCP_dom	C4BPA CSMD2 SEZ6L2	1.12e-03	57	67	3	IPR000436
Domain	CUB_dom	CSMD2 SEZ6L2 DCBLD2	1.12e-03	57	67	3	IPR000859
Domain	VWD	FCGBP MUC5AC	1.47e-03	16	67	2	SM00216
Domain	VWF_type-D	FCGBP MUC5AC	1.47e-03	16	67	2	IPR001846
Domain	VWFD	FCGBP MUC5AC	1.47e-03	16	67	2	PS51233
Domain	VWD	FCGBP MUC5AC	1.47e-03	16	67	2	PF00094
Domain	Gal_mutarotase_SF_dom	MGAM MGAM2	1.67e-03	17	67	2	IPR011013
Domain	WHTH_DNA-bd_dom	RGS6 IRF3 RECQL RGS9 RGS7	1.76e-03	242	67	5	IPR011991
Domain	VWC_out	FCGBP MUC5AC	2.08e-03	19	67	2	SM00215
Domain	ADAM_spacer1	THSD4 ADAMTS20	3.06e-03	23	67	2	IPR010294
Domain	ADAM_spacer1	THSD4 ADAMTS20	3.06e-03	23	67	2	PF05986
Pathway	WP_METABOLISM_OF_ALPHALINOLENIC_ACID	ALOX12 ALOX5 ALOX15	9.96e-07	6	53	3	M39844
Pathway	REACTOME_BIOSYNTHESIS_OF_SPECIALIZED_PRORESOLVING_MEDIATORS_SPMS	ALOX12 ALOX5 ALOX15	4.66e-05	19	53	3	M27889
Pathway	WP_EICOSANOID_SYNTHESIS	ALOX12 ALOX5 ALOX15	7.35e-05	22	53	3	MM15961
Pathway	REACTOME_BIOSYNTHESIS_OF_SPECIALIZED_PRORESOLVING_MEDIATORS_SPMS	ALOX12 ALOX5 ALOX15	7.35e-05	22	53	3	MM15614
Pathway	WP_EICOSANOID_SYNTHESIS	ALOX12 ALOX5 ALOX15	8.43e-05	23	53	3	M39382
Pathway	WP_OXYLIPINS_PATHWAYS	ALOX12 ALOX5 ALOX15	9.61e-05	24	53	3	MM17249
Pathway	REACTOME_SYNTHESIS_OF_LIPOXINS_LX	ALOX12 ALOX5	1.38e-04	5	53	2	MM14859
Pathway	REACTOME_BIOSYNTHESIS_OF_E_SERIES_18_S_RESOLVINS	ALOX5 ALOX15	1.38e-04	5	53	2	MM15617
Pathway	WP_EICOSANOID_METABOLISM_VIA_LIPOOXYGENASES_LOX	ALOX12 ALOX5 ALOX15	1.71e-04	29	53	3	M39858
Pathway	REACTOME_SYNTHESIS_OF_LIPOXINS_LX	ALOX12 ALOX5	2.06e-04	6	53	2	M27138
Pathway	REACTOME_BIOSYNTHESIS_OF_EPA_DERIVED_SPMS	ALOX5 ALOX15	2.06e-04	6	53	2	M27890
Pathway	REACTOME_BIOSYNTHESIS_OF_EPA_DERIVED_SPMS	ALOX5 ALOX15	2.06e-04	6	53	2	MM15615
Pathway	WP_PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM_IN_SENESCENCE_WP5122	ALOX12 ALOX5 ALOX15	2.09e-04	31	53	3	M42531
Pathway	WP_EICOSANOID_METABOLISM_VIA_LIPOXYGENASES_LOX	ALOX12 ALOX5 ALOX15	2.53e-04	33	53	3	MM15963
Pathway	WP_MYOMETRIAL_RELAXATION_AND_CONTRACTION_PATHWAYS	SLC8A1 RGS6 OXTR RGS9 RGS7	2.74e-04	154	53	5	MM15974
Pathway	WP_PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM_IN_SENESCENCE_WP5321	ALOX12 ALOX5 ALOX15	2.77e-04	34	53	3	M48061
Pathway	REACTOME_SYNTHESIS_OF_12_EICOSATETRAENOIC_ACID_DERIVATIVES	ALOX12 ALOX15	2.88e-04	7	53	2	M27139
Pathway	REACTOME_SYNTHESIS_OF_12_EICOSATETRAENOIC_ACID_DERIVATIVES	ALOX12 ALOX15	2.88e-04	7	53	2	MM14860
Pathway	WP_MYOMETRIAL_RELAXATION_AND_CONTRACTION_PATHWAYS	SLC8A1 RGS6 OXTR RGS9 RGS7	2.91e-04	156	53	5	M39475
Pathway	REACTOME_COOPERATION_OF_PDCL_PHLP1_AND_TRIC_CCT_IN_G_PROTEIN_BETA_FOLDING	RGS6 RGS9 RGS7	3.86e-04	38	53	3	M27656
Pathway	REACTOME_CHAPERONIN_MEDIATED_PROTEIN_FOLDING	RGS6 RGS9 RGS7	4.17e-04	39	53	3	MM15003
Pathway	KEGG_MEDICUS_REFERENCE_GLYCOGEN_DEGRADATION_AMYLASE_	MGAM MGAM2	4.91e-04	9	53	2	M47622
Pathway	WP_OMEGA6FATTY_ACIDS_IN_SENESCENCE	ALOX12 ALOX5 ALOX15	1.27e-03	57	53	3	M48332
Pathway	KEGG_ARACHIDONIC_ACID_METABOLISM	ALOX12 ALOX5 ALOX15	1.34e-03	58	53	3	M5410
Pathway	REACTOME_ARACHIDONIC_ACID_METABOLISM	ALOX12 ALOX5 ALOX15	1.41e-03	59	53	3	M27140
Pathway	REACTOME_ARACHIDONIC_ACID_METABOLISM	ALOX12 ALOX5 ALOX15	1.55e-03	61	53	3	MM14861
Pathway	WP_PATHWAYS_OF_NUCLEIC_ACID_METABOLISM_AND_INNATE_IMMUNE_SENSING	OAS1 IRF3	1.61e-03	16	53	2	M39846
Pubmed	Human 5-, 12- and 15-lipoxygenase-1 coexist in kidney but show opposite trends and their balance changes in cancer.	ALOX12 ALOX5 ALOX15	7.15e-09	3	68	3	22825379
Pubmed	5-Lipoxygenase, but not 12/15-lipoxygenase, contributes to degeneration of retinal capillaries in a mouse model of diabetic retinopathy.	ALOX12 ALOX5 ALOX15	7.15e-09	3	68	3	18346986
Pubmed	Experimental allergic encephalomyelitis is exacerbated in mice deficient for 12/15-lipoxygenase or 5-lipoxygenase.	ALOX12 ALOX5 ALOX15	7.15e-09	3	68	3	15328042
Pubmed	5 S,15 S-Dihydroperoxyeicosatetraenoic Acid (5,15-diHpETE) as a Lipoxin Intermediate: Reactivity and Kinetics with Human Leukocyte 5-Lipoxygenase, Platelet 12-Lipoxygenase, and Reticulocyte 15-Lipoxygenase-1.	ALOX12 ALOX5 ALOX15	7.15e-09	3	68	3	30407793
Pubmed	The molecular biology of mammalian lipoxygenases and the quest for eicosanoid functions using lipoxygenase-deficient mice.	ALOX12 ALOX5 ALOX15	7.15e-09	3	68	3	8944751
Pubmed	Differential contribution of lipoxygenase isozymes to nigrostriatal vulnerability.	ALOX12 ALOX5 ALOX15	7.15e-09	3	68	3	23079635
Pubmed	Functional characterization of genetic enzyme variations in human lipoxygenases.	ALOX12 ALOX5 ALOX15	2.86e-08	4	68	3	24282679
Pubmed	Identification of 12/15-lipoxygenase as a regulator of axon degeneration through high-content screening.	ALOX12 ALOX5 ALOX15	2.86e-08	4	68	3	25698732
Pubmed	Dual 12/15- and 5-lipoxygenase deficiency in macrophages alters arachidonic acid metabolism and attenuates peritonitis and atherosclerosis in ApoE knock-out mice.	ALOX12 ALOX5 ALOX15	2.86e-08	4	68	3	19509298
Pubmed	Human lipoxygenase pathway gene variation and association with markers of subclinical atherosclerosis in the diabetes heart study.	ALOX12 ALOX5 ALOX15	2.86e-08	4	68	3	20592751
Pubmed	Levels of expression of lipoxygenases and cyclooxygenase-2 in human breast cancer.	ALOX12 ALOX5 ALOX15	2.86e-08	4	68	3	12907138
Pubmed	Neonatal imprinting of alveolar macrophages via neutrophil-derived 12-HETE.	ALOX12 ALOX5 ALOX15	7.13e-08	5	68	3	36599368
Pubmed	mRNA levels of enzymes and receptors implicated in arachidonic acid metabolism in gliomas.	ALOX12 ALOX5 ALOX15	1.42e-07	6	68	3	20382140
Pubmed	Lack of effect of common single nucleotide polymorphisms in leukotriene pathway genes on platelet reactivity in patients with diabetes.	ALOX12 ALOX5 ALOX15	1.42e-07	6	68	3	23828562
Pubmed	Expression of inactive glutathione peroxidase 4 leads to embryonic lethality, and inactivation of the Alox15 gene does not rescue such knock-in mice.	ALOX12 ALOX5 ALOX15	1.42e-07	6	68	3	25313597
Pubmed	Palmitoylation regulates plasma membrane-nuclear shuttling of R7BP, a novel membrane anchor for the RGS7 family.	RGS6 RGS9 RGS7	1.42e-07	6	68	3	15897264
Pubmed	Class A scavenger receptor-mediated macrophage adhesion requires coupling of calcium-independent phospholipase A(2) and 12/15-lipoxygenase to Rac and Cdc42 activation.	ALOX12 ALOX5 ALOX15	2.49e-07	7	68	3	17873277
Pubmed	Murine 12/15-lipoxygenase regulates ATP-binding cassette transporter G1 protein degradation through p38- and JNK2-dependent pathways.	PLOD3 ALOX12 ALOX15	3.98e-07	8	68	3	19713213
Pubmed	Emerging role of 12/15-Lipoxygenase (ALOX15) in human pathologies.	ALOX12 ALOX15	3.77e-06	2	68	2	30472260
Pubmed	Glutathione disulfide induces neural cell death via a 12-lipoxygenase pathway.	ALOX12 ALOX15	3.77e-06	2	68	2	19373248
Pubmed	Relationship between lipoxygenase and human testicular cancer.	ALOX12 ALOX5	3.77e-06	2	68	2	14767568
Pubmed	Platelet-type 12-lipoxygenase deletion provokes a compensatory 12/15-lipoxygenase increase that exacerbates oxidative stress in mouse islet β cells.	ALOX12 ALOX15	3.77e-06	2	68	2	30792307
Pubmed	Reduced dietary omega-6 to omega-3 fatty acid ratio and 12/15-lipoxygenase deficiency are protective against chronic high fat diet-induced steatohepatitis.	ALOX12 ALOX15	3.77e-06	2	68	2	25251155
Pubmed	A role for the mouse 12/15-lipoxygenase pathway in promoting epithelial wound healing and host defense.	ALOX12 ALOX15	3.77e-06	2	68	2	15708862
Pubmed	Proteomic and lipidomic profiling of demyelinating lesions identifies fatty acids as modulators in lesion recovery.	ALOX5 ALOX15	3.77e-06	2	68	2	34706241
Pubmed	Role of Src tyrosine kinase in the atherogenic effects of the 12/15-lipoxygenase pathway in vascular smooth muscle cells.	ALOX12 ALOX15	3.77e-06	2	68	2	19095999
Pubmed	The Investigation of Lipoxygenases as Therapeutic Targets in Malignant Pleural Mesothelioma.	ALOX12 ALOX5	3.77e-06	2	68	2	30941737
Pubmed	Differential expression and localization of 12/15 lipoxygenases in adipose tissue in human obese subjects.	ALOX12 ALOX15	3.77e-06	2	68	2	21094135
Pubmed	Different roles of 12/15-lipoxygenase in diabetic large and small fiber peripheral and autonomic neuropathies.	ALOX12 ALOX5	3.77e-06	2	68	2	20724598
Pubmed	Interaction between RGS7 and polycystin.	PKD1 RGS7	3.77e-06	2	68	2	10339594
Pubmed	Enhancement role of host 12/15-lipoxygenase in melanoma progression.	ALOX12 ALOX15	3.77e-06	2	68	2	23664097
Pubmed	Association with the Plasma Membrane Is Sufficient for Potentiating Catalytic Activity of Regulators of G Protein Signaling (RGS) Proteins of the R7 Subfamily.	RGS9 RGS7	3.77e-06	2	68	2	26811338
Pubmed	Lipoxygenase metabolites are mediators of PTH-dependent human osteoblast growth.	ALOX12 ALOX15	3.77e-06	2	68	2	18187376
Pubmed	EGF stimulates lipoxin A4 synthesis and modulates repair in corneal epithelial cells through ERK and p38 activation.	ALOX12 ALOX15	3.77e-06	2	68	2	21220563
Pubmed	12/15-lipoxygenase expressed in non-epithelial cells causes airway epithelial injury in asthma.	ALOX12 ALOX15	3.77e-06	2	68	2	23528921
Pubmed	RGS9, a GTPase accelerator for phototransduction.	RGS9 RGS7	3.77e-06	2	68	2	9459445
Pubmed	Polymorphisms in the human ALOX12 and ALOX15 genes are associated with peak bone mineral density in Chinese nuclear families.	ALOX12 ALOX15	3.77e-06	2	68	2	22089472
Pubmed	Mutations in a new gene encoding a protein of the hair bundle cause non-syndromic deafness at the DFNB16 locus.	STRC STRCP1	3.77e-06	2	68	2	11687802
Pubmed	Alox12/15 Deficiency Exacerbates, While Lipoxin A4 Ameliorates Hepatic Inflammation in Murine Alcoholic Hepatitis.	ALOX12 ALOX15	3.77e-06	2	68	2	32760397
Pubmed	Arachidonate 12/15-lipoxygenase-induced inflammation and oxidative stress are involved in the development of diabetic cardiomyopathy.	ALOX12 ALOX15	3.77e-06	2	68	2	25187369
Pubmed	12/15-Lipoxygenase signaling in the endoplasmic reticulum stress response.	ALOX12 ALOX15	3.77e-06	2	68	2	22215650
Pubmed	12/15-lipoxygenase is required for the early onset of high fat diet-induced adipose tissue inflammation and insulin resistance in mice.	ALOX12 ALOX15	3.77e-06	2	68	2	19787041
Pubmed	Isotope sensitive branching and kinetic isotope effects in the reaction of deuterated arachidonic acids with human 12- and 15-lipoxygenases.	ALOX12 ALOX15	3.77e-06	2	68	2	18547056
Pubmed	12-Lipoxygenase-knockout mice are resistant to inflammatory effects of obesity induced by Western diet.	ALOX12 ALOX15	3.77e-06	2	68	2	18780776
Pubmed	Mechanistic investigations of human reticulocyte 15- and platelet 12-lipoxygenases with arachidonic acid.	ALOX12 ALOX15	3.77e-06	2	68	2	19469483
Pubmed	The evolutionary hypothesis of reaction specificity of mammalian ALOX15 orthologs.	ALOX12 ALOX15	3.77e-06	2	68	2	30237084
Pubmed	12/15-lipoxygenase is increased in Alzheimer's disease: possible involvement in brain oxidative stress.	ALOX12 ALOX15	3.77e-06	2	68	2	15111312
Pubmed	Polymorphisms in ALOX12, but not ALOX15, are significantly associated with BMD in postmenopausal women.	ALOX12 ALOX15	3.77e-06	2	68	2	17520163
Pubmed	Human ALOX12, but not ALOX15, is associated with BMD in white men and women.	ALOX12 ALOX15	3.77e-06	2	68	2	16598376
Pubmed	Molecular basis for the reduced catalytic activity of the naturally occurring T560M mutant of human 12/15-lipoxygenase that has been implicated in coronary artery disease.	ALOX5 ALOX15	3.77e-06	2	68	2	21558275
Pubmed	Expression of 12/15-lipoxygenase attenuates intracellular lipid deposition during in vitro foam cell formation.	ALOX12 ALOX15	3.77e-06	2	68	2	15681297
Pubmed	Common polymorphisms in 5-lipoxygenase and 12-lipoxygenase genes and the risk of incident, sporadic colorectal adenoma.	ALOX12 ALOX5	3.77e-06	2	68	2	17236225
Pubmed	Amelioration of the Alzheimer's disease phenotype by absence of 12/15-lipoxygenase.	ALOX12 ALOX15	3.77e-06	2	68	2	20570249
Pubmed	Biosynthesis of the Maresin Intermediate, 13S,14S-Epoxy-DHA, by Human 15-Lipoxygenase and 12-Lipoxygenase and Its Regulation through Negative Allosteric Modulators.	ALOX12 ALOX15	3.77e-06	2	68	2	32324389
Pubmed	Expression of lipoxygenase in human prostate cancer and growth reduction by its inhibitors.	ALOX12 ALOX5	3.77e-06	2	68	2	15010818
Pubmed	Reactive oxygen species and 12/15-lipoxygenase contribute to the antiproliferative capacity of alternatively activated myeloid cells elicited during helminth infection.	ALOX12 ALOX15	3.77e-06	2	68	2	15879104
Pubmed	Expression of 5-lipoxygenase and 15-lipoxygenase in rheumatoid arthritis synovium and effects of intraarticular glucocorticoids.	ALOX5 ALOX15	3.77e-06	2	68	2	19497113
Pubmed	Dual-vector gene therapy restores cochlear amplification and auditory sensitivity in a mouse model of DFNB16 hearing loss.	STRC STRCP1	3.77e-06	2	68	2	34910522
Pubmed	Expression of lipoxygenase in human bladder carcinoma and growth inhibition by its inhibitors.	ALOX12 ALOX5	3.77e-06	2	68	2	14532840
Pubmed	Networks of enzymatically oxidized membrane lipids support calcium-dependent coagulation factor binding to maintain hemostasis.	ALOX12 ALOX15	3.77e-06	2	68	2	29184033
Pubmed	Resistance to type 1 diabetes induction in 12-lipoxygenase knockout mice.	ALOX12 ALOX15	3.77e-06	2	68	2	10330425
Pubmed	Conversion of human 5-lipoxygenase to a 15-lipoxygenase by a point mutation to mimic phosphorylation at Serine-663.	ALOX5 ALOX15	3.77e-06	2	68	2	22516296
Pubmed	Reciprocal regulation of 12- and 15-lipoxygenases by UV-irradiation in human keratinocytes.	ALOX12 ALOX15	3.77e-06	2	68	2	18755188
Pubmed	12-Lipoxygenase isoenzymes in mouse skin tumor development.	ALOX12 ALOX15	3.77e-06	2	68	2	7576099
Pubmed	The 12/15-lipoxygenase as an emerging therapeutic target for Alzheimer's disease.	ALOX12 ALOX15	3.77e-06	2	68	2	25708815
Pubmed	Lipoxygenase-catalyzed transformation of epoxy fatty acids to hydroxy-endoperoxides: a potential P450 and lipoxygenase interaction.	ALOX12 ALOX15	3.77e-06	2	68	2	25293588
Pubmed	Kinetic investigations of the rate-limiting step in human 12- and 15-lipoxygenase.	ALOX12 ALOX15	3.77e-06	2	68	2	12731864
Pubmed	Macromolecular composition dictates receptor and G protein selectivity of regulator of G protein signaling (RGS) 7 and 9-2 protein complexes in living cells.	RGS9 RGS7	3.77e-06	2	68	2	23857581
Pubmed	The 12/15-lipoxygenase pathway counteracts fibroblast activation and experimental fibrosis.	ALOX12 ALOX15	3.77e-06	2	68	2	22267335
Pubmed	Lack of association of ALOX12 and ALOX15 polymorphisms with aspirin-exacerbated respiratory disease in Korean patients.	ALOX12 ALOX15	3.77e-06	2	68	2	19663136
Pubmed	12/15-lipoxygenase counteracts inflammation and tissue damage in arthritis.	ALOX12 ALOX15	3.77e-06	2	68	2	19675173
Pubmed	Overexpression of 12/15-lipoxygenase increases anxiety behavior in female mice.	ALOX12 ALOX15	3.77e-06	2	68	2	24300237
Pubmed	Endogenous LXA4 circuits are determinants of pathological angiogenesis in response to chronic injury.	ALOX5 ALOX15	3.77e-06	2	68	2	20008149
Pubmed	Integrative predictive model of coronary artery calcification in atherosclerosis.	RGS9 MME DMPK ALOX12 ALOX5 ALOX15	5.94e-06	229	68	6	19948975
Pubmed	A novel regulator of G-protein signaling bearing GAP activity for Galphai and Galphaq in megakaryocytes.	RGS6 RGS9 RGS7	6.77e-06	19	68	3	11342430
Pubmed	Macrophage 12/15 lipoxygenase expression increases plasma and hepatic lipid levels and exacerbates atherosclerosis.	ALOX12 ALOX15	1.13e-05	3	68	2	22279185
Pubmed	Cochlear outer hair cell horizontal top connectors mediate mature stereocilia bundle mechanics.	STRC STRCP1	1.13e-05	3	68	2	30801007
Pubmed	Host genetic risk factors for West Nile virus infection and disease progression.	OAS1 IRF3	1.13e-05	3	68	2	21935451
Pubmed	Restoring multidrug resistance-associated protein 3 attenuates cell proliferation in the polycystic kidney.	ABCC3 PKD1	1.13e-05	3	68	2	25143454
Pubmed	Improved survival and reduced vascular permeability by eliminating or blocking 12/15-lipoxygenase in mouse models of acute lung injury (ALI).	ALOX12 ALOX15	1.13e-05	3	68	2	19752233
Pubmed	RGS7/Gβ5/R7BP complex regulates synaptic plasticity and memory by modulating hippocampal GABABR-GIRK signaling.	RGS6 RGS7	1.13e-05	3	68	2	24755289
Pubmed	Human pancreatic mucinous cystadenoma is characterized by distinct mucin, cytokeratin and CD10 expression compared with intraductal papillary-mucinous adenoma.	MME MUC5AC	1.13e-05	3	68	2	16722930
Pubmed	Smooth muscle-specific expression of calcium-independent phospholipase A2β (iPLA2β) participates in the initiation and early progression of vascular inflammation and neointima formation.	ALOX12 ALOX15	1.13e-05	3	68	2	22637477
Pubmed	Transcriptional regulation of β-secretase-1 by 12/15-lipoxygenase results in enhanced amyloidogenesis and cognitive impairments.	ALOX12 ALOX15	1.13e-05	3	68	2	22275252
Pubmed	Role of 12/15-lipoxygenase in the expression of MCP-1 in mouse macrophages.	ALOX12 ALOX15	1.13e-05	3	68	2	18296557
Pubmed	Relationship between 12/15-lipoxygenase and COX-2 in mesangial cells: potential role in diabetic nephropathy.	ALOX12 ALOX15	1.13e-05	3	68	2	16514433
Pubmed	Following experimental stroke, the recovering brain is vulnerable to lipoxygenase-dependent semaphorin signaling.	ALOX12 ALOX15	1.13e-05	3	68	2	23070608
Pubmed	Phospholipid membranes drive abdominal aortic aneurysm development through stimulating coagulation factor activity.	ALOX12 ALOX15	1.13e-05	3	68	2	30944221
Pubmed	Insulin-like growth factor I reduces lipid oxidation and foam cell formation via downregulation of 12/15-lipoxygenase.	ALOX12 ALOX15	1.13e-05	3	68	2	25549319
Pubmed	Hyperoxidation of ether-linked phospholipids accelerates neutrophil extracellular trap formation.	ALOX5 ALOX15	1.13e-05	3	68	2	29167447
Pubmed	12/15-lipoxygenase-dependent myeloid production of interleukin-12 is essential for resistance to chronic toxoplasmosis.	ALOX12 ALOX15	1.13e-05	3	68	2	19822654
Pubmed	Regulators of G protein signaling 6 and 7. Purification of complexes with gbeta5 and assessment of their effects on g protein-mediated signaling pathways.	RGS6 RGS7	1.13e-05	3	68	2	10521509
Pubmed	Oxidative metabolism of a fatty acid amide hydrolase-regulated lipid, arachidonoyltaurine.	ALOX12 ALOX15	1.13e-05	3	68	2	18311922
Pubmed	Conductance and block of hair-cell mechanotransducer channels in transmembrane channel-like protein mutants.	TMC2 TMC3	1.13e-05	3	68	2	24981230
Pubmed	Effects of silencing leukocyte-type 12/15-lipoxygenase using short interfering RNAs.	ALOX12 ALOX15	1.13e-05	3	68	2	15576842
Pubmed	Stereocilin-deficient mice reveal the origin of cochlear waveform distortions.	STRC STRCP1	2.25e-05	4	68	2	18849963
Pubmed	cDNA cloning of a 8-lipoxygenase and a novel epidermis-type lipoxygenase from phorbol ester-treated mouse skin.	ALOX12 ALOX15	2.25e-05	4	68	2	9518531
Pubmed	Characterization of human 12-lipoxygenase genes.	ALOX12 ALOX15	2.25e-05	4	68	2	1570320
Pubmed	R7BP augments the function of RGS7*Gbeta5 complexes by a plasma membrane-targeting mechanism.	RGS9 RGS7	2.25e-05	4	68	2	16867977
Pubmed	Selective interleukin-12 synthesis defect in 12/15-lipoxygenase-deficient macrophages associated with reduced atherosclerosis in a mouse model of familial hypercholesterolemia.	ALOX12 ALOX15	2.25e-05	4	68	2	12122008
Interaction	RGS7BP interactions	RGS6 RGS9 RGS7	1.94e-06	8	67	3	int:RGS7BP
Cytoband	19q13.3	GYS1 SIGLEC10 DMPK	2.42e-04	82	67	3	19q13.3
Cytoband	15q15.3	STRC STRCP1	6.16e-04	25	67	2	15q15.3
Cytoband	Ensembl 112 genes in cytogenetic band chr1p35	SMPDL3B SERINC2 CSMD2	1.08e-03	137	67	3	chr1p35
Cytoband	Ensembl 112 genes in cytogenetic band chr19q13	FCGBP TMEM190 GYS1 SIGLEC10 IRF3 LMTK3 DMPK	1.75e-03	1192	67	7	chr19q13
GeneFamily	Arachidonate lipoxygenases	ALOX12 ALOX5 ALOX15	3.07e-07	6	46	3	407
GeneFamily	Regulators of G-protein signaling	RGS6 RGS9 RGS7	1.99e-05	21	46	3	720
GeneFamily	Transmembrane channel likes	TMC2 TMC3	1.76e-04	8	46	2	1135
GeneFamily	Hyalectan proteoglycans\|V-set domain containing\|Sushi domain containing\|C-type lectin domain containing	C4BPA CSMD2 SEZ6L2	4.10e-04	57	46	3	1179
ToppCell	Control-Epithelial_cells-Airway_mucous\|Control / group, cell type (main and fine annotations)	ABCC3 FCGBP RGS6 SERINC2 MUC5AC MGAM2 MYBPC1	1.29e-08	183	68	7	15d24a4fb1ffe6cbafbd54fcd7dde9ddcfbe03b2
ToppCell	Parenchymal-NucSeq-Immune_Myeloid-Macrophage_other-Macro_AW_CX3CR1\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	MGAM CELA3B SLC8A1 FCGBP ALOX5 FAM111B STAB1	2.22e-08	198	68	7	732a43061d75bc5e1cf23f5056b72cd10c926668
ToppCell	COVID-19-Heart-CM_+_Macrophage\|Heart / Disease (COVID-19 only), tissue and cell type	THSD4 ABCC3 MGAM SLC8A1 FCGBP STAB1	2.40e-07	170	68	6	4232fe937909f93d3736988c707b8f95ce993398
ToppCell	3'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.2.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MGAM FCGBP TMEM190 MUC5AC ALOX15 DNAH11	4.61e-07	190	68	6	2fdc024d3d673a0134b74b4c5a63afe924995730
ToppCell	Bronchial-10x5prime-Immune_Myeloid-Macrophage_other-Macro_AW_CX3CR1\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	SLC8A1 FCGBP SIGLEC10 ALOX5 FAM111B STAB1	5.54e-07	196	68	6	b15812354128c12a588d79ef449d787e74835f3b
ToppCell	367C-Myeloid-Macrophage-FABP4+_Macrophage_2\|367C / Donor, Lineage, Cell class and subclass (all cells)	ABCC3 NPTN SCD MME ALOX5	4.11e-06	156	68	5	1a0e081284a99c1b345990775015b8a2fa469496
ToppCell	3'-Adult-SmallIntestine-Epithelial-epithelial_progenitor_cell\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MGAM OXTR MME LMTK3 MGAM2	5.89e-06	168	68	5	4e2e4c88ada772e9ba6e72c9ae3a05c063e93318
ToppCell	3'-Adult-SmallIntestine-Epithelial-epithelial_progenitor_cell-TA\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MGAM OXTR MME LMTK3 MGAM2	5.89e-06	168	68	5	ee4dab089adef2f47a9d39d91934523331a8b81c
ToppCell	nucseq-Epithelial-Epithelial_Glandular\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	FCGBP RGS6 MUC5AC MGAM2 MYBPC1	8.02e-06	179	68	5	859cd8ee414ad6207c046ada2e655e49322dd01c
ToppCell	nucseq-Epithelial-Epithelial_Glandular-Goblet\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	FCGBP RGS6 MUC5AC MGAM2 MYBPC1	8.24e-06	180	68	5	3dc80bc636bf0e6ffc9762853132a9fe59fd1f66
ToppCell	nucseq-Epithelial-Epithelial_Glandular-Goblet-Goblet\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	FCGBP RGS6 MUC5AC MGAM2 MYBPC1	8.24e-06	180	68	5	668a2d8e1d5a390309d5eb62c836f5903144bea9
ToppCell	P03-Endothelial-lymphatic_endothelial_cell-endothelial_cell_of_lymphatic_vessel\|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	OXTR SMPDL3B ASTN1 DMTN STAB1	8.93e-06	183	68	5	89727b4f65949ed2dce9d2e0228c79fe4280230c
ToppCell	P03-Endothelial-lymphatic_endothelial_cell\|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	OXTR SMPDL3B ASTN1 DMTN STAB1	8.93e-06	183	68	5	113e6d8d4bb271be984af06cd6c22b180425dcfc
ToppCell	facs-Liver-Non-hepatocytes-24m-Endothelial-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	THSD4 PTPRB TMEM190 RGS9 ALOX15	8.93e-06	183	68	5	ebe369dc80c4fbf8f4dbe947147f8c47507ffb60
ToppCell	Control-Epithelial_cells-Airway_goblet\|Control / group, cell type (main and fine annotations)	FCGBP RGS6 MUC5AC MGAM2 MYBPC1	9.17e-06	184	68	5	d92a71441e4e19f8c301999d8186f8e48e3cd162
ToppCell	Multiple_Sclerosis-Other-Platelet\|Multiple_Sclerosis / Disease, Lineage and Cell Type	ABCC3 RGS6 OXTR ALOX12 DMTN	9.41e-06	185	68	5	2e480dde7ecb2f88ff005f86ef732a1cf0209d45
ToppCell	368C-Myeloid-Macrophage-FABP4+_Macrophage_3\|368C / Donor, Lineage, Cell class and subclass (all cells)	SCD OAS1 SERINC2 MME ALOX5	9.66e-06	186	68	5	ddfadd43efeac3b3e6b7062590cc2b8f2f2db2ab
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_3\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	THSD4 SLC8A1 RGS6 SERINC2 CSMD2	9.66e-06	186	68	5	4780af76237d7af2abbe2d8d5530cdf53e3ed0b7
ToppCell	LPS-IL1RA+antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_3\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	THSD4 SLC8A1 RGS6 SERINC2 CSMD2	9.66e-06	186	68	5	a95744b8649096bd7cfc3591a02841fa411085b3
ToppCell	Healthy/Control-Platelet\|World / Disease group and Cell class	ABCC3 RGS6 OXTR ALOX12 DMTN	1.02e-05	188	68	5	552077e4597d0956f4d8c40c9de8f109e87cb857
ToppCell	368C-Epithelial_cells-Epithelial-E_(AT2)\|368C / Donor, Lineage, Cell class and subclass (all cells)	SMPDL3B SCD C4BPA B4GALNT3 SEZ6L2	1.04e-05	189	68	5	6f2322d017b74a1757c81d6e06f50ead8c3dd0cc
ToppCell	mild_COVID-19-Platelet\|World / disease group, cell group and cell class (v2)	ABCC3 RGS6 OXTR ALOX12 DMTN	1.04e-05	189	68	5	038ec3c266b89416bb5b774ba522d916394961da
ToppCell	Healthy/Control-Platelet\|Healthy/Control / Disease group and Cell class	ABCC3 RGS6 OXTR ALOX12 DMTN	1.04e-05	189	68	5	3de7f8d8b8451ed9a146cce499552e9a060e9099
ToppCell	368C-Epithelial_cells-Epithelial-E_(AT2)-\|368C / Donor, Lineage, Cell class and subclass (all cells)	SMPDL3B SCD C4BPA B4GALNT3 SEZ6L2	1.04e-05	189	68	5	926b5fa3064b501a57ba78583e8af33532add455
ToppCell	PBMC-Mild-Hematopoietic-Platelet-Platelet-plt_1\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	ABCC3 RGS6 OXTR ALOX12 DMTN	1.07e-05	190	68	5	b719061be370ffc293854f1f6e526bf33cd2f442
ToppCell	COVID-19_Moderate-Platelet\|World / disease group, cell group and cell class	ABCC3 RGS6 OXTR ALOX12 DMTN	1.07e-05	190	68	5	6e4f4af5ba185bb022753881a26a269a544bb59b
ToppCell	368C-Epithelial_cells\|368C / Donor, Lineage, Cell class and subclass (all cells)	SMPDL3B SCD C4BPA B4GALNT3 SEZ6L2	1.07e-05	190	68	5	459811e88d3001816c2d89034e0921c24918c17f
ToppCell	PBMC-Mild-Hematopoietic-Platelet-Platelet-plt_1\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	ABCC3 RGS6 OXTR ALOX12 DMTN	1.07e-05	190	68	5	427038bae9c7b3a9441c8d59ace69da74e9d37bf
ToppCell	PBMC-Severe-Hematopoietic-Platelet-Platelet-plt_1\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	ABCC3 RGS6 OXTR ALOX12 DMTN	1.10e-05	191	68	5	7da172553ed6df4a0c34ecd55665a9598b5071a5
ToppCell	PBMC-Severe-Hematopoietic-Platelet-Platelet-plt_1\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	ABCC3 RGS6 OXTR ALOX12 DMTN	1.10e-05	191	68	5	1a1bf85bc77bf093a0ac2cb9eabaeac820a7b93e
ToppCell	mild_COVID-19-Platelet\|mild_COVID-19 / disease group, cell group and cell class (v2)	ABCC3 RGS6 OXTR ALOX12 DMTN	1.10e-05	191	68	5	968e2d48969884dd21b8a87f199af94a7410b0dd
ToppCell	Adult-Immune-alveolar_macrophage_(MARCO_positive)-D122\|Adult / Lineage, Cell type, age group and donor	ABCC3 SLC8A1 SIGLEC10 MME ALOX5	1.15e-05	193	68	5	cc1b6d3bf56e4a88f6fe23dd036a83cf5538c958
ToppCell	343B-Epithelial_cells-Epithelial-G_(Club-Clara_cells)-\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	ABCC3 FCGBP OAS1 MME MUC5AC	1.15e-05	193	68	5	8ede7038a222c7e7ecaf7e86520823cf606cbee7
ToppCell	343B-Epithelial_cells-Epithelial-G_(Club-Clara_cells)\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	ABCC3 FCGBP OAS1 MME MUC5AC	1.15e-05	193	68	5	0e7d7adfaa7191e34038fcda6677561ae13934eb
ToppCell	367C-Myeloid-Macrophage-FABP4+_Macrophage\|367C / Donor, Lineage, Cell class and subclass (all cells)	ABCC3 SCD SERINC2 MME ALOX5	1.18e-05	194	68	5	40c91ed945bd5990a0dbf2090d37a660b19aaab2
ToppCell	Bronchial-NucSeq-Immune_Myeloid-Macrophage_other-Macro_AW_CX3CR1\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	MGAM FCGBP SIGLEC10 ALOX5 STAB1	1.27e-05	197	68	5	0a404b4494a2246d5a92299235056f0fda4d2b48
ToppCell	5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	FCGBP OAS1 SERINC2 LMTK3 MUC5AC	1.27e-05	197	68	5	adb4e27d73ae2e6a39d212c0ead3ac0ad62d9131
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Myeloid-Macrophage-macrophage,_alveolar-Macro_c1-C1QC\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	SLC8A1 SCD FUCA1 ALOX5 STAB1	1.31e-05	198	68	5	579a22199643440b98e381147779ced630d4ed66
ToppCell	Bronchial_Brush-Immune-Luminal_Macrophages\|Immune / Tissue, Lineage and Cell class of Lung Cells from 10X	ABCC3 SCD OAS1 MME ALOX5	1.31e-05	198	68	5	77f41f0e0895b7c732bab1fd2e047f2ed31cbd9d
ToppCell	10x_5'_v1-Non-neoplastic-Myeloid\|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	SLC8A1 FCGBP SIGLEC10 ALOX5 STAB1	1.31e-05	198	68	5	e1a0c809302a3b304775bd708201ad412a98d711
ToppCell	Control-Epithelial_cells-Cycling_epithelial\|Control / group, cell type (main and fine annotations)	FCGBP RGS6 MUC5AC MGAM2 MYBPC1	1.31e-05	198	68	5	b43290d2f8ca45b4a21cb6dbdf1b4384897672e0
ToppCell	Tracheal-10x3prime_v2-Immune_Myeloid-Macrophage_other-Macro_AW_CX3CR1\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	SLC8A1 FCGBP SIGLEC10 ALOX5 STAB1	1.34e-05	199	68	5	514dbf128b6832b1cbd65be023d4fe02400e8dec
ToppCell	10x_5'_v1-Non-neoplastic-Myeloid-TAM-BDM-TAM-BDM_anti-infl\|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	SLC8A1 FCGBP SIGLEC10 ALOX5 STAB1	1.34e-05	199	68	5	de9c1c801eb34faf01760df07d5ff6bbd561e152
ToppCell	Tracheal-NucSeq-Immune_Myeloid-Macrophage_alveolar\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ABCC3 SLC8A1 MME ALOX5 STAB1	1.34e-05	199	68	5	98c0d57c247d39bc771d81f4387f8dd01222628e
ToppCell	10x_5'_v1-Non-neoplastic-Myeloid-TAM-BDM\|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	SLC8A1 FCGBP SIGLEC10 ALOX5 STAB1	1.34e-05	199	68	5	0d447ca1a77120aac068857ff0ddc2ed6942ed3e
ToppCell	Tracheal-NucSeq-Immune_Myeloid-Macrophage_alveolar-Macro_alveolar\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ABCC3 SLC8A1 MME ALOX5 STAB1	1.34e-05	199	68	5	b818d46a39c8782188d82dc8931b8eec9d549dd1
ToppCell	10x_5'_v1-Non-neoplastic-Myeloid-TAM-BDM-TAM-BDM_anti-infl-Z\|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	SLC8A1 FCGBP SIGLEC10 ALOX5 STAB1	1.34e-05	199	68	5	45e2f44a0ed39cb9ba061a03874c1fe746856c2d
ToppCell	Parenchymal-10x3prime_v2-Immune_Myeloid-Macrophage_other-Macrophage_intermediate\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	PPP1R15B SIGLEC10 NCR3LG1 ALOX5 STAB1	1.34e-05	199	68	5	ccd473accf2205c120c0d32031619e421558a861
ToppCell	COVID-19-COVID-19_Mild-Others\|COVID-19_Mild / Disease, condition lineage and cell class	ABCC3 RGS6 OXTR ALOX12 DMTN	1.37e-05	200	68	5	ecf94be4bb961ec343471547f2ea327bc6f709f4
ToppCell	MS-Multiple_Sclerosis-Others-Platelet\|Multiple_Sclerosis / Disease, condition lineage and cell class	ABCC3 RGS6 OXTR ALOX12 DMTN	1.37e-05	200	68	5	263d956136747c209951b4358f2e1672a21d8eef
ToppCell	COVID-19-COVID-19_Mild-Others-Platelet\|COVID-19_Mild / Disease, condition lineage and cell class	ABCC3 RGS6 OXTR ALOX12 DMTN	1.37e-05	200	68	5	bf5e7a36d6ed44a30f906702b40ace3ecd423398
ToppCell	Tracheal-10x5prime-Immune_Myeloid-Macrophage_other-Macro_AW_CX3CR1\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	SLC8A1 FCGBP SIGLEC10 ALOX5 STAB1	1.37e-05	200	68	5	27f498bcd706d0751091662996795b5270e46f14
ToppCell	(51)_cDC1\|World / shred on Cell_type and subtype	SLC8A1 SIGLEC10 FUCA1 ALOX15 MGAM2	1.51e-05	204	68	5	a8cf4180c406674b7541917d1fc6127686ba5f8a
ToppCell	PBMC-Control-Myeloid-Neutrophil-Neutrophil-Neu_1\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	MGAM PTPRB MME TMC3	6.62e-05	142	68	4	191a13bba143ecdfc2bfd797c3ac191481388298
ToppCell	PBMC-Control-Myeloid-Neutrophil-Neutrophil-Neu_1\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	MGAM PTPRB MME TMC3	6.80e-05	143	68	4	b405dba9a83a99cc7b53ce71772bc52a0bbb0d4e
ToppCell	Hippocampus-Neuronal-Excitatory-eN1(Slc17a7)-eN1_2\|Hippocampus / BrainAtlas - Mouse McCarroll V32	HGF SLC8A1 KCNG1 CSMD2	7.57e-05	147	68	4	8f725ff8fb4ced5db2643e80669d3f7945b820ab
ToppCell	PND10-Immune-Immune_Myeloid-Granulocytic\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	HGF MGAM ALOX5 ALOX15	7.98e-05	149	68	4	c9334f319a0c943268e54b6f0c9446736172c3a9
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SLC8A1 RGS6 SIGLEC10 B4GALNT3	8.84e-05	153	68	4	9b6675ace8a83c8d446b722301d0ec4e6840f3fc
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22-Myeloid-Dendritic-conventional_dendritic_cell\|Severe-critical_progression_d12-22 / Compartment, severity and other cell annotations on 10x 3' data (130k)	TMC2 SIGLEC10 NCR3LG1 DCBLD2	8.84e-05	153	68	4	ee6f4770c6e35d59bdeec5b0ecb10119fa8c3ca5
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22-Myeloid-Dendritic\|Severe-critical_progression_d12-22 / Compartment, severity and other cell annotations on 10x 3' data (130k)	TMC2 SIGLEC10 NCR3LG1 DCBLD2	8.84e-05	153	68	4	a35149a0c8b4ec9ad27cc4b3d34fba3b8714a6a2
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22-Myeloid-Dendritic-conventional_dendritic_cell-DC_c2-CD1C\|Severe-critical_progression_d12-22 / Compartment, severity and other cell annotations on 10x 3' data (130k)	TMC2 SIGLEC10 NCR3LG1 DCBLD2	8.84e-05	153	68	4	90cd6efda83c0b4b80eae2c90e7ff45dfd936dc2
ToppCell	PND07-Immune-Immune_Myeloid-Granulocytic\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	HGF MGAM ALOX5 ALOX15	9.07e-05	154	68	4	f92d83c5f8b532fe5624f1cd352632f543d96ea9
ToppCell	PND07-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC-EPC_mature\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PHKA1 PTPRB RGS9 STAB1	9.53e-05	156	68	4	1928c86deb3bcd01db4ae76919a351066aadb39a
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SLC8A1 RGS6 SIGLEC10 B4GALNT3	9.77e-05	157	68	4	2c5295043611bac7dfa4aef2146681bce4a33a8f
ToppCell	LPS-antiTNF-Endothelial-Mes-Like\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PTPRB DNAJC10 L3MBTL3 FAM111B	1.00e-04	158	68	4	50df52d64d07178975563abd98ce4fddb9f2f7ef
ToppCell	368C-Myeloid-Macrophage-FABP4+_Macrophage_2\|368C / Donor, Lineage, Cell class and subclass (all cells)	SCD OAS1 SERINC2 ALOX5	1.05e-04	160	68	4	ac3f56f8ab8efd11c4b4868a828db05c23ac762f
ToppCell	droplet-Kidney-KIDNEY-30m-Epithelial-Epcam____brush_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MGAM SCD MME SLC23A1	1.10e-04	162	68	4	de0fde4310a56dc96bfc134c44d104993526d9bc
ToppCell	normal_Lung-Epithelial_cells-Undetermined\|normal_Lung / Location, Cell class and cell subclass	SCD C4BPA MME ALOX5	1.16e-04	164	68	4	fa2dae15b38cb8f9642dbf00549beec8ee19e9bb
ToppCell	facs-Marrow-T_cells-18m-Myeloid-basophil\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HGF CELA3B ALOX5 ALOX15	1.21e-04	166	68	4	c22b0f3bf990d94b615a3aacee5de548da2db628
ToppCell	facs-Marrow-T_cells-18m-Myeloid-basophil\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HGF CELA3B ALOX5 ALOX15	1.21e-04	166	68	4	0975fc165bcc7e85f053d9d0244fffe407c23571
ToppCell	5'-GW_trimst-2-SmallIntestine-Epithelial-neuro-epithelial-K_cells_(GIP+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MGAM TMEM190 SEZ6L2 RGS7	1.21e-04	166	68	4	afba41e15478053f11815acf568d29187de75492
ToppCell	droplet-Kidney-nan-18m-Epithelial-Epcam____brush_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABCC3 SCD MME SLC23A1	1.24e-04	167	68	4	ed7e785dcd25777f64e0c2596ada4f5a5ea17121
ToppCell	droplet-Kidney-nan-3m-Epithelial-Epcam____brush_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABCC3 SCD MME SLC23A1	1.24e-04	167	68	4	40d102e01ccbc7262d00fafd59ca5234909009cb
ToppCell	3'-Distal_airway-Epithelial-Epithelial_transtional-secretory-bronchial_goblet_cell-Goblet_(bronchial)-Goblet_(bronchial)_L.0.4.2.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	FCGBP DNAJC10 MUC5AC MYBPC1	1.27e-04	168	68	4	b275e951ff7109e36da22fc17bd4516f9b9432c4
ToppCell	3'-Distal_airway-Epithelial-Epithelial_transtional-secretory-bronchial_goblet_cell\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	FCGBP DNAJC10 MUC5AC MYBPC1	1.27e-04	168	68	4	0757a5af953901a8faed5774ffec4755fc9c0a6e
ToppCell	Sigmoid-Macrophage-Macrophage\|Macrophage / Region, Cell class and subclass	SLC8A1 SIGLEC10 PRPF38B FUCA1	1.27e-04	168	68	4	bb16e135b6ae0d66615420b61edd6f62f2a3233c
ToppCell	3'-Distal_airway-Epithelial-Epithelial_transtional-secretory-bronchial_goblet_cell-Goblet_(bronchial)\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	FCGBP DNAJC10 MUC5AC MYBPC1	1.27e-04	168	68	4	a0dbe2ee697e29b32aa5f8326445e067ff66c154
ToppCell	droplet-Kidney-KIDNEY-1m-Epithelial-Epcam____brush_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KCNG1 SCD MME SLC23A1	1.27e-04	168	68	4	35ce3b2b9c9997d4c101da5949c7271d6a6b8f12
ToppCell	droplet-Large_Intestine-COLON_PROXIMAL-30m-Epithelial-Lgr5+_amplifying_undifferentiated_cell\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PGBD1 B4GALNT3 MED13 DNAH11	1.27e-04	168	68	4	d69452e2cfeb74023b5cf3d09064d7dcad0008ec
ToppCell	390C-Myeloid-Macrophage-M2-like_Macrophage_(MARCO_negative)\|390C / Donor, Lineage, Cell class and subclass (all cells)	ABCC3 SLC8A1 FCGBP STAB1	1.30e-04	169	68	4	2c851b2703c7b8b656026f996f5fc027e4a79b36
ToppCell	droplet-Kidney-nan-18m-Epithelial-brush_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABCC3 SCD MME SLC23A1	1.30e-04	169	68	4	f00741203efa0b948db7223ee8c19bdd0918258a
ToppCell	wk_15-18-Hematologic-Meg-ery-Megakaryocyte\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	ABCC3 RGS6 ALOX12 DMTN	1.30e-04	169	68	4	d571e84e01e3316748d4407ed98881b17484e035
ToppCell	wk_20-22-Hematologic-Meg-ery-Megakaryocyte\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	ABCC3 RGS6 ALOX12 DMTN	1.33e-04	170	68	4	eace4dd09cdbde0fa40a6aa0f3dba1114d0ce475
ToppCell	PND07-Immune-Immune_Myeloid-Granulocytic-Basophil\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	HGF CELA3B ALOX5 ALOX15	1.33e-04	170	68	4	bca78719c17355772ad6c53ee75e459faf1d089f
ToppCell	PND07-Immune-Immune_Myeloid-Granulocytic-Basophil-Basophil_mature\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	HGF CELA3B ALOX5 ALOX15	1.33e-04	170	68	4	40d863554ec98ae43f76511c1112859688846613
ToppCell	droplet-Kidney-nan-21m-Epithelial-brush_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABCC3 SCD MME SLC23A1	1.36e-04	171	68	4	007f148f4611ea1826edfa9f91ced36541ad9f5a
ToppCell	droplet-Kidney-nan-21m-Epithelial-Epcam____brush_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABCC3 SCD MME SLC23A1	1.36e-04	171	68	4	8e7223ba447947cdf4e1c82a52fd90439cf3d8f6
ToppCell	Control-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_3\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	THSD4 RGS6 SERINC2 CSMD2	1.36e-04	171	68	4	4ede831aed364cb5271f49a8b09bb6d0452f9b35
ToppCell	metastatic_Lymph_Node-Myeloid_cells-Microglia/Mac\|metastatic_Lymph_Node / Location, Cell class and cell subclass	FCGBP GYS1 MUC5AC STAB1	1.39e-04	172	68	4	f673a2e697b46e7cfa4186cb3fb2b98e3c83703e
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2-Exc_L5-6_FEZF2_ANKRD20A1\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SMPDL3B B4GALNT3 TMC3 MYBPC1	1.39e-04	172	68	4	ddecdb1a0791296929790f78b49008f51a130f8b
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Epithelial-neuro-epithelial\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CELA3B TMEM190 SEZ6L2 RGS7	1.42e-04	173	68	4	46ed379571385684145b5cb6dd4ae340ac546e64
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SMPDL3B RGS9 B4GALNT3 TMC3	1.42e-04	173	68	4	95c723b09254ae7131fe5ba0841472502e83269b
ToppCell	facs-Marrow-Granulocytes-3m-Myeloid-basophil\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HGF CELA3B ALOX5 ALOX15	1.48e-04	175	68	4	1b35acece23712ab7e3f92d9d68266efd38b3ef5
ToppCell	droplet-Liver-Npc-21m-Lymphocytic\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	THSD4 FCGBP RGS7 ALOX15	1.48e-04	175	68	4	046e841811b22c39f80a9752f3223c1906de6f20
ToppCell	Dendritic_Cells-IPF_02\|World / lung cells shred on cell class, cell subclass, sample id	SLC8A1 FCGBP SIGLEC10 STAB1	1.48e-04	175	68	4	584290a51f9975782a5ac8c6ad67c778d8323f8c
ToppCell	facs-Kidney-nan-18m-Epithelial-epithelial_cell_of_proximal_tubule\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABCC3 SCD MME SLC23A1	1.48e-04	175	68	4	076ad81d6cbeea5512393d192af3ab5aa1f82975
ToppCell	droplet-Heart-HEART-1m-Hematologic-leukocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABCC3 SMPDL3B ALOX5 STAB1	1.48e-04	175	68	4	a2fed97cf8d28f9936fe791e5e8c43d2430330c9
ToppCell	facs-Marrow-Granulocytes-3m-Myeloid-basophil\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HGF CELA3B ALOX5 ALOX15	1.48e-04	175	68	4	a9f88054e2c28d604c65ed785f63021aadb7f4c8
ToppCell	facs-Kidney-nan-18m-Epithelial-epithelial_cell_of_proximal_tubule\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABCC3 SCD MME SLC23A1	1.48e-04	175	68	4	445ccb9744a3a9ff37164c532afbe769d306b6c8
ToppCell	10x5'-lymph-node_spleen-Hematopoietic_Erythro-Mega\|lymph-node_spleen / Manually curated celltypes from each tissue	ABCC3 RGS6 ALOX12 DMTN	1.48e-04	175	68	4	5ca3369ce2c2bb88ba097260195aecd67cec1a3a
Drug	sinensetin	MME ALOX12 ALOX5 ALOX15	1.14e-07	16	66	4	CID000145659
Drug	N-(3-phenoxycinnamyl)acetohydroxamic acid	ALOX12 ALOX5 ALOX15	2.32e-07	5	66	3	ctd:C056614
Drug	artonin E	ALOX12 ALOX5 ALOX15	2.32e-07	5	66	3	CID005481962
Drug	isamoxole	ALOX12 ALOX5 ALOX15	4.62e-07	6	66	3	CID000042118
Drug	1-oleoyl-2-DHA-PC	ALOX12 ALOX5 ALOX15	4.62e-07	6	66	3	CID006438829
Drug	CPHU	ALOX12 ALOX5 ALOX15	4.62e-07	6	66	3	CID000124471
Drug	BW A797C	ALOX12 ALOX5 ALOX15	4.62e-07	6	66	3	CID006439067
Drug	octadecadienoic acid	SCD ALOX12 ALOX5 ALOX15	5.47e-07	23	66	4	CID005312457
Drug	pinolenic acid	SCD ALOX12 ALOX5 ALOX15	7.78e-07	25	66	4	CID005312493
Drug	12-IODE	ALOX12 ALOX5 ALOX15	8.08e-07	7	66	3	CID006450050
Drug	AC1L3WDO	SCD ALOX12 ALOX5 ALOX15	9.17e-07	26	66	4	CID000123344
Drug	sulfapyridine	ALOX12 ALOX5 ALOX15 MYBPC1	1.07e-06	27	66	4	CID000005336
Drug	colneleic acid	ALOX12 ALOX5 ALOX15	1.29e-06	8	66	3	CID006441681
Drug	Cgs 22745	ALOX12 ALOX5 ALOX15	1.29e-06	8	66	3	CID006439321
Drug	TEI-8005	ALOX12 ALOX5 ALOX15	1.29e-06	8	66	3	CID006438655
Drug	htyA	ALOX12 ALOX5 ALOX15	1.29e-06	8	66	3	CID000152267
Drug	CDNQ	ALOX12 ALOX5 ALOX15	1.29e-06	8	66	3	CID000126468
Drug	Perhexiline maleate [6724-53-4]; Up 200; 10.2uM; PC3; HT_HG-U133A	PTPRB RGS6 OAS1 MME MUC5AC ALOX12 ALOX5	1.77e-06	199	66	7	5081_UP
Drug	14,15-leukotriene A4	ALOX12 ALOX5 ALOX15	1.93e-06	9	66	3	CID006439604
Drug	octadeca-9,12-dien-1-ol	ALOX12 ALOX5 ALOX15	1.93e-06	9	66	3	CID000068168
Drug	U-56467	ALOX12 ALOX5 ALOX15	1.93e-06	9	66	3	CID006439532
Drug	8,15-diHPETE	ALOX12 ALOX5 ALOX15	1.93e-06	9	66	3	CID005283181
Drug	T 0757	ALOX12 ALOX5 ALOX15	1.93e-06	9	66	3	CID006439291
Drug	13-hydroxylinoleic acid	ALOX12 ALOX5 ALOX15	1.93e-06	9	66	3	CID006438633
Drug	AC1NSXHC	ALOX12 ALOX5 ALOX15	1.93e-06	9	66	3	CID005371969
Drug	U-66,855	ALOX12 ALOX5 ALOX15	1.93e-06	9	66	3	CID000127235
Drug	ODYA	ALOX12 ALOX5 ALOX15	1.93e-06	9	66	3	CID000001931
Drug	A-78773	ALOX12 ALOX5 ALOX15	1.93e-06	9	66	3	CID000071460
Drug	S 19812	ALOX12 ALOX5 ALOX15	1.93e-06	9	66	3	CID005744460
Drug	AC1L1TSE	ABCC3 MME ALOX12 ALOX5 ALOX15	2.11e-06	72	66	5	CID000060719
Drug	(Z)-7-[(1R,2R,3R)-2-[(1E,3S,5Z)-3-hydroxyocta-1,5-dienyl]-3-methyl-5-oxocyclopentyl]hept-5-enoic acid	SCD ALOX12 ALOX5 ALOX15	2.47e-06	33	66	4	CID009548573
Drug	EP 10045	ALOX12 ALOX5 ALOX15	2.75e-06	10	66	3	CID000127575
Drug	9-HPODE	ALOX12 ALOX5 ALOX15	2.75e-06	10	66	3	CID000001928
Drug	1,4-pentadiene	ALOX12 ALOX5 ALOX15	2.75e-06	10	66	3	CID000011587
Drug	LTE5	ALOX12 ALOX5 ALOX15	3.78e-06	11	66	3	CID006439533
Drug	acetone phenylhydrazone	ALOX12 ALOX5 ALOX15	3.78e-06	11	66	3	CID000066026
Drug	Ity A	ALOX12 ALOX5 ALOX15	3.78e-06	11	66	3	CID000188274
Drug	BW A137C	ALOX12 ALOX5 ALOX15	3.78e-06	11	66	3	CID000129265
Drug	nonenal	ALOX12 ALOX5 ALOX15	5.02e-06	12	66	3	CID003015503
Drug	eicosa-8,11,14-trienoic acid	PLOD3 SCD ALOX12 ALOX5 ALOX15	5.71e-06	88	66	5	CID000003011
Drug	AC1NR1Q2	ALOX12 ALOX5 ALOX15	6.52e-06	13	66	3	CID005283190
Drug	CV-6504	ALOX12 ALOX5 ALOX15	6.52e-06	13	66	3	CID000093543
Drug	AC1L1BGZ	ALOX12 ALOX5 ALOX15	6.52e-06	13	66	3	CID000001435
Drug	9-HETE	ALOX12 ALOX5 ALOX15	6.52e-06	13	66	3	CID000001926
Drug	hypolaetin	ALOX12 ALOX5 ALOX15	6.52e-06	13	66	3	CID005281648
Drug	ICI207968	ALOX12 ALOX5 ALOX15	6.52e-06	13	66	3	CID000129095
Drug	AC1O4E1A	ALOX12 ALOX5 ALOX15	6.52e-06	13	66	3	CID006365736
Drug	stearic acid	MGAM SCD PIGV ALOX12 ALOX5 ALOX15	6.78e-06	159	66	6	CID000005281
Drug	BAY X 1005	MUC5AC ALOX12 ALOX5 ALOX15	7.30e-06	43	66	4	CID000123723
Drug	acetone phenylhydrazone	ALOX12 ALOX5	8.28e-06	2	66	2	ctd:C045543
Drug	AC1L4H9B	DMPK DMTN	8.28e-06	2	66	2	CID000157032
Drug	AC1NR1LB	ALOX12 ALOX5 ALOX15	8.28e-06	14	66	3	CID005283131
Drug	Ro 19-3704	MME ALOX12 ALOX15	8.28e-06	14	66	3	CID000129364
Drug	YS06	MGAM ALOX12 ALOX5	8.28e-06	14	66	3	CID000484586
Drug	oxphaman	ALOX12 ALOX5 ALOX15	8.28e-06	14	66	3	CID005464022
Drug	timegadine	ALOX12 ALOX5 ALOX15	8.28e-06	14	66	3	CID000068902
Drug	5-HEPE	ALOX12 ALOX5 ALOX15	8.28e-06	14	66	3	CID000001766
Drug	17-HdoHE	ALOX12 ALOX5 ALOX15	8.28e-06	14	66	3	CID006439179
Drug	flurbiprofen	GYS1 MME ALOX12 ALOX5 SDHB ALOX15	1.03e-05	171	66	6	CID000003394
Drug	8R-HpETE	ALOX12 ALOX5 ALOX15	1.03e-05	15	66	3	CID005283170
Drug	Hex-3-enyl acetate	ALOX12 ALOX5 ALOX15	1.03e-05	15	66	3	CID000015574
Drug	8(S),15(S)-diHETE	ALOX12 ALOX5 ALOX15	1.03e-05	15	66	3	CID000001897
Drug	13-HpOTrE	ALOX12 ALOX5 ALOX15	1.03e-05	15	66	3	CID005282866
Drug	AC1NR1M2	ALOX12 ALOX5 ALOX15	1.27e-05	16	66	3	CID005283140
Drug	12R-HETrE	ALOX12 ALOX5 ALOX15	1.27e-05	16	66	3	CID005283149
Drug	peroxylinolenic acid	ALOX12 ALOX5 ALOX15	1.27e-05	16	66	3	CID006439905
Drug	hex-3-enal	ALOX12 ALOX5 ALOX15	1.27e-05	16	66	3	CID000023234
Drug	butylethanolamine	PHKA1 MGAM GYS1	1.27e-05	16	66	3	CID000249006
Drug	A63162	ALOX12 ALOX5 ALOX15	1.27e-05	16	66	3	CID000121876
Drug	5,15-diHETE	ALOX12 ALOX5 ALOX15	1.54e-05	17	66	3	CID005283158
Drug	cirsiliol	ALOX12 ALOX5 ALOX15	1.54e-05	17	66	3	CID000160237
Drug	2 CS	ALOX12 ALOX5 ALOX15	1.54e-05	17	66	3	CID000060923
Drug	7,7-dimethyleicosadienoic acid	ALOX12 ALOX5 ALOX15	1.54e-05	17	66	3	CID000001877
Drug	FPL 57231	ALOX12 ALOX5 ALOX15	1.84e-05	18	66	3	CID000122212
Drug	diphenyl disulfide	ALOX12 ALOX5 ALOX15	1.84e-05	18	66	3	CID000013436
Drug	3-nonenal	ALOX12 ALOX5 ALOX15	1.84e-05	18	66	3	CID005283336
Drug	BW540C	ALOX12 ALOX5 ALOX15	1.84e-05	18	66	3	CID000134372
Drug	AC1O5PL5	ALOX12 ALOX5 ALOX15	1.84e-05	18	66	3	CID006438380
Drug	AC1L1X0Y	SCD C4BPA ALOX12 ALOX5 ALOX15	2.29e-05	117	66	5	CID000062388
Drug	NSC186061	DMPK ALOX12 ALOX5 ALOX15 DMTN	2.38e-05	118	66	5	CID000004163
Drug	dithiol	ALOX12 ALOX5	2.48e-05	3	66	2	ctd:C004848
Drug	Acetyl benzyl disulfide	MGAM DMPK	2.48e-05	3	66	2	CID000193413
Drug	1,3-dimethylthymine	DMPK DMTN	2.48e-05	3	66	2	CID000078112
Drug	4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine	ALOX12 ALOX5	2.48e-05	3	66	2	ctd:D015772
Drug	4-(3-chlorophenyl)thiosemicarbazide	MGAM DMPK	2.48e-05	3	66	2	CID000707050
Drug	13(R)-hydroxy-octadeca-(9Z,11E,15Z)-trienoic acid	ALOX12 ALOX15	2.48e-05	3	66	2	CID000643726
Drug	N2 76	MGAM DMPK	2.48e-05	3	66	2	CID000192216
Drug	L-651,392	ALOX12 ALOX5 ALOX15	2.56e-05	20	66	3	CID000122182
Drug	TMK777	ALOX12 ALOX5 ALOX15	2.56e-05	20	66	3	CID006438911
Drug	AC1L2P35	ALOX12 ALOX5 ALOX15	2.56e-05	20	66	3	CID000125736
Drug	AC1O5S1P	ALOX12 ALOX5 ALOX15	2.98e-05	21	66	3	CID006439617
Drug	AC1NRAUB	ALOX12 ALOX5 ALOX15	2.98e-05	21	66	3	CID005288098
Drug	20-carboxyleukotriene B4	ALOX12 ALOX5 ALOX15	2.98e-05	21	66	3	CID000001588
Drug	AC1L1FO2	ALOX12 ALOX5 ALOX15	2.98e-05	21	66	3	CID000003321
Drug	BM 13.177	ALOX12 ALOX5 ALOX15	3.44e-05	22	66	3	CID000051550
Drug	5,8,11-eicosatrienoic acid	ALOX12 ALOX5 ALOX15	3.44e-05	22	66	3	CID000004028
Drug	CGS 8515	ALOX12 ALOX5 ALOX15	3.44e-05	22	66	3	CID000163944
Drug	diethylcarbamazine	ALOX12 ALOX5 ALOX15	3.44e-05	22	66	3	CID000003052
Drug	L-656,224	ALOX12 ALOX5 ALOX15	3.95e-05	23	66	3	CID000128132
Drug	AC1NSYHD	ALOX12 ALOX5 ALOX15	3.95e-05	23	66	3	CID005319705
Disease	autosomal recessive nonsyndromic deafness 16 (implicated_via_orthology)	STRC STRCP1	5.08e-06	2	67	2	DOID:0110471 (implicated_via_orthology)
Disease	COVID-19 symptoms measurement	DPP9 OAS1 MUC5AC	6.95e-05	35	67	3	EFO_0600019
Disease	pancreatic cancer (is_marker_for)	HGF ABCC3 MUC5AC ALOX5	8.40e-05	101	67	4	DOID:1793 (is_marker_for)
Disease	congestive heart failure (biomarker_via_orthology)	SLC8A1 MME ALOX12 ALOX15	1.05e-04	107	67	4	DOID:6000 (biomarker_via_orthology)
Disease	biliary tract benign neoplasm (is_marker_for)	HGF MUC5AC	1.06e-04	7	67	2	DOID:0050625 (is_marker_for)
Disease	transverse temporal cortex volume measurement	HGF RGS6	2.26e-04	10	67	2	EFO_0010336
Disease	cholangiocarcinoma (is_marker_for)	HGF MUC5AC ALOX5	4.22e-04	64	67	3	DOID:4947 (is_marker_for)
Disease	gastric ulcer (implicated_via_orthology)	OXTR MUC5AC	4.54e-04	14	67	2	DOID:10808 (implicated_via_orthology)
Disease	response to methotrexate, aspartate aminotransferase measurement	THSD4 TMC2	4.54e-04	14	67	2	EFO_0004736, GO_0031427
Disease	Diabetic Asymmetric Polyneuropathy	HGF MME	4.54e-04	14	67	2	C0393835
Disease	Diabetic Neuralgia	HGF MME	4.54e-04	14	67	2	C0751074
Disease	Diabetic Neuropathies	HGF MME	4.54e-04	14	67	2	C0011882
Disease	Asymmetric Diabetic Proximal Motor Neuropathy	HGF MME	4.54e-04	14	67	2	C0271674
Disease	Symmetric Diabetic Proximal Motor Neuropathy	HGF MME	4.54e-04	14	67	2	C0271673
Disease	Diabetic Mononeuropathy	HGF MME	4.54e-04	14	67	2	C0271678
Disease	Diabetic Autonomic Neuropathy	HGF MME	4.54e-04	14	67	2	C0271686
Disease	Diabetic Amyotrophy	HGF MME	4.54e-04	14	67	2	C0271685
Disease	Diabetic Polyneuropathies	HGF MME	4.54e-04	14	67	2	C0271680
Disease	COVID-19, osteoarthritis	DPP9 OAS1	9.40e-04	20	67	2	MONDO_0005178, MONDO_0100096
Disease	serum gamma-glutamyl transferase measurement	THSD4 NPTN PKD1 OAS1 L3MBTL3 MED13 DMTN STAB1	1.07e-03	914	67	8	EFO_0004532
Disease	hepatocellular carcinoma (biomarker_via_orthology)	ABCC3 PIK3R2 MME	1.93e-03	108	67	3	DOID:684 (biomarker_via_orthology)
Disease	1,5 anhydroglucitol measurement	MGAM MGAM2	1.98e-03	29	67	2	EFO_0008009
Disease	respiratory failure, COVID-19	DPP9 OAS1	1.98e-03	29	67	2	EFO_0009686, MONDO_0100096

Protein segments in the cluster

Peptide	Gene	Start	Entry
SGNRTWYPEVPKCEW	C4BPA	526	P04003
PWVEYWEFLGCFVDL	ANKLE2	576	Q86XL3
PGWPGFYKDALSCAW	CSMD2	766	Q7Z408
HCGATPQWPEGYWEV	B4GALNT3	911	Q6L9W6
PQDLGWNPYVASWID	DNAH11	2321	Q96DT5
WWPTPADVSEDYEAD	CCDC142	56	Q17RM4
FPDWTFPSAWVCTYD	ERMP1	886	Q7Z2K6
CIRNEWGTNQGPWPY	ASTN1	506	O14525
DMFTWDPYGPWEGCT	ADAMTS20	846	P59510
PYFWPSNCWEPENTD	RGS6	116	P49758
PYFWPTQQWPAEDTD	RGS9	106	O75916
PFGSYSEEDIWWALE	ABCC3	1386	O15438
GWNNCYDYWIDADSP	L3MBTL3	511	Q96JM7
ESFCWPEWGLAEQYP	PLOD3	141	O60568
WKGPPDWTDYNDFEL	PTPRB	1281	P23467
WEFWVPSTPVGAYFC	MAFIP	26	Q8WZ33
VPRCFFPWNWGYEAS	MGAM2	81	Q2M2H8
CEWPLFWTYFILDGV	PHKA1	326	P46020
WPSYQLQDGEAWPPE	NCR3LG1	326	Q68D85
AGPWGDYLCDSPWAL	SMPDL3B	56	Q92485
TVFPDYTNPNCAVWW	MGAM	496	O43451
ADYWYDILQSCWRPP	LMTK3	381	Q96Q04
GEWECPDTYWNSTNF	FUCA1	231	P04066
LPDIYGWPVATENWE	MME	161	P08473
GQLDWYSWVPNAPCT	ALOX15	546	P16050
PEFTSIPACYWWAVI	KCNG1	406	Q9UIX4
CAWTKWFDVDFPSPG	MUC5AC	4631	P98088
WCYTGNPLIPWDYCP	HGF	451	P14210
GQLDWYAWVPNAPCT	ALOX12	546	P18054
WLNYPCFKNWDGSPV	OAS1	326	P00973
DCWAVFIQPWGPKAY	OXTR	186	P30559
GPECDWWALGVFAYE	DMPK	256	Q09013
SPPSLQDAEWYWGDI	PIK3R2	321	O00459
IQEEFDRFTGYWWCP	DPP9	246	Q86TI2
LPNYEATCWLWGDPH	FCGBP	1666	Q9Y6R7
CLPNYEATCWLWGDP	FCGBP	2866	Q9Y6R7
NGEDAVPYSWPWQVS	CELA3B	31	P08861
PGYTAFWQIWCALFP	GPR161	186	Q8N6U8
PGPPWAAFATDEYQW	DCBLD2	336	Q96PD2
WVIDFYAPWCGPCQN	DNAJC10	691	Q8IXB1
EFCPTPDNWFSIEPW	FAM111B	521	Q6SJ93
GELWDTCNIGVPWYD	GYS1	131	P13807
YWPCPPSLAVVETEW	DMTN	191	Q08495
DEAWLVACAWPPFPY	PKD1	1396	P98161
RYALWFCVGESWPQD	IRF3	341	Q14653
QTPYFWPSNCWEPEN	RGS7	111	P49802
WPSNCWEPENTDYAV	RGS7	116	P49802
WCWDLESKFPEYGEF	TMC3	541	Q7Z5M5
FGQYDWCSWIPNAPP	ALOX5	556	P09917
PDWPQSYSPGQDCVW	SEZ6L2	541	Q6UXD5
PLPDWFWSACPQAQY	MED13	2076	Q9UHV7
WCGTTTQGYLVWFEP	PGBD1	571	Q96JS3
DWLEEGIHWQYSPPD	PPP1R15B	141	Q5SWA1
PDIFWGCFLENETLW	STRC	466	Q7RTU9
YDSSPAAWNKEDFPW	RECQL	61	P46063
NEPPWCFWDVPLIYS	PIGV	291	Q9NUD9
GFFYPWSCEGDIWDR	TMEM190	26	Q8WZ59
RWKCPPEEEIYGNWS	SLC23A1	126	Q9UHI7
RYTQPPTDLWDWFES	PRPF38B	166	Q5VTL8
YCDVVGSPTPEIQWW	NPTN	51	Q9Y639
EACWRFYPKFWTSPP	STAB1	1906	Q9NY15
CFILPTLVPWYFWGE	SCD	226	O00767
PDIFWGCFLENETLW	STRCP1	466	A6NGW2
WCWDLEAGFPSYAEF	TMC2	616	Q8TDI7
CNIFPCPAFWDIGEW	THSD4	671	Q6ZMP0
CPSYWWNGDKYLGPA	SDHB	196	P21912
FNWAFEECPPPSFSW	SIGLEC10	166	Q96LC7
PEGYETQWWDAPSIV	SERINC2	311	Q96SA4
FVPPTEYWNGWACFI	SLC8A1	791	P32418
VGDDWCIMNWEPPAY	MYBPC1	631	Q00872