Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionbeta-1,3-galactosyltransferase activity

C1GALT1 B3GNT5

1.83e-0415272GO:0048531
GeneOntologyMolecularFunctiongalactosyltransferase activity

C1GALT1 B3GNT5

1.02e-0335272GO:0008378
GeneOntologyMolecularFunctionDNA endonuclease activity

APEX1 DNASE2

1.61e-0344272GO:0004520
GeneOntologyMolecularFunctionDNA nuclease activity

APEX1 DNASE2

3.69e-0367272GO:0004536
GeneOntologyMolecularFunctioncatalytic activity, acting on DNA

APEX1 DNASE2 POLE2

5.18e-03262273GO:0140097
DomainFatty_acid_hydroxylase

MSMO1 SC5D

3.01e-056272IPR006694
DomainFA_hydroxylase

MSMO1 SC5D

3.01e-056272PF04116
PathwayKEGG_MEDICUS_REFERENCE_CHOLESTEROL_BIOSYNTHESIS

MSMO1 SC5D

1.33e-0413192M47945
PathwayWP_CHOLESTEROL_BIOSYNTHESIS

MSMO1 SC5D

1.79e-0415192MM15921
PathwayWP_CHOLESTEROL_BIOSYNTHESIS_PATHWAY

MSMO1 SC5D

1.79e-0415192M39608
PathwayKEGG_STEROID_BIOSYNTHESIS

MSMO1 SC5D

2.31e-0417192M5872
PathwayWP_CHOLESTEROL_SYNTHESIS_DISORDERS

MSMO1 SC5D

2.60e-0418192M45528
PathwayREACTOME_PCNA_DEPENDENT_LONG_PATCH_BASE_EXCISION_REPAIR

APEX1 POLE2

3.56e-0421192M27505
PathwayREACTOME_PCNA_DEPENDENT_LONG_PATCH_BASE_EXCISION_REPAIR

APEX1 POLE2

3.56e-0421192MM15230
PathwayWP_SYNTHESIS_OF_CERAMIDES_AND_1DEOXYCERAMIDES

CERS6 B3GNT5

3.91e-0422192M45544
PathwayREACTOME_RESOLUTION_OF_AP_SITES_VIA_THE_MULTIPLE_NUCLEOTIDE_PATCH_REPLACEMENT_PATHWAY

APEX1 POLE2

5.07e-0425192M541
PathwayREACTOME_RESOLUTION_OF_AP_SITES_VIA_THE_MULTIPLE_NUCLEOTIDE_PATCH_REPLACEMENT_PATHWAY

APEX1 POLE2

5.49e-0426192MM14481
PathwayREACTOME_CHOLESTEROL_BIOSYNTHESIS

MSMO1 SC5D

5.92e-0427192MM14735
PathwayREACTOME_CHOLESTEROL_BIOSYNTHESIS

MSMO1 SC5D

5.92e-0427192M16227
PathwayWP_BASE_EXCISION_REPAIR

APEX1 POLE2

7.82e-0431192M39861
PathwayKEGG_BASE_EXCISION_REPAIR

APEX1 POLE2

9.97e-0435192M5500
PathwayWP_ENTEROCYTE_CHOLESTEROL_METABOLISM

MSMO1 SC5D

1.06e-0336192M48067
PathwayREACTOME_METABOLISM_OF_LIPIDS

PLA2R1 CERS6 B3GNT5 MSMO1 SC5D

1.13e-03620195MM15193
PathwayREACTOME_RESOLUTION_OF_ABASIC_SITES_AP_SITES

APEX1 POLE2

1.18e-0338192M27701
PathwayREACTOME_RESOLUTION_OF_ABASIC_SITES_AP_SITES

APEX1 POLE2

1.24e-0339192MM17222
PathwayWP_CHOLESTEROL_METABOLISM_WITH_BLOCH_AND_KANDUTSCHRUSSELL_PATHWAYS

MSMO1 SC5D

1.79e-0347192M39853
PathwayWP_CHOLESTEROL_METABOLISM_WITH_BLOCH_AND_KANDUTSCHRUSSELL_PATHWAYS

MSMO1 SC5D

2.19e-0352192MM15920
PathwayREACTOME_METABOLISM_OF_LIPIDS

PLA2R1 CERS6 B3GNT5 MSMO1 SC5D

2.73e-03757195M27451
PathwayREACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS

C1GALT1 B3GNT5

2.91e-0360192MM15636
PathwayREACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS

C1GALT1 B3GNT5

3.10e-0362192M546
PathwayREACTOME_BASE_EXCISION_REPAIR

APEX1 POLE2

3.61e-0367192MM15429
PathwayWP_CHOLESTEROL_METABOLISM

MSMO1 SC5D

4.16e-0372192M46457
Pubmed

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.

SLC6A8 APEX1 MYOF PLA2R1 C1GALT1 CERS6 MSMO1 SC5D DNASE2 CLPTM1

1.15e-081201271035696571
Pubmed

Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia.

APEX1 SC5D CLPTM1 PITX2

1.19e-0433127420634891
Pubmed

Systematic protein-protein interaction mapping for clinically relevant human GPCRs.

SLC6A8 CERS6 MRAP2 MSMO1 CLPTM1

1.78e-0469727528298427
Pubmed

Large-scale identification of human genes implicated in epidermal barrier function.

LIPK A2ML1

2.49e-043027217562024
Pubmed

A compendium of expression patterns of cholesterol biosynthetic enzymes in the mouse embryo.

MSMO1 SC5D

3.80e-043727226108225
Pubmed

Proteomic and yeast 2-hybrid screens to identify PTEN binding partners.

APEX1 MYOF CASD1

7.06e-0422627337839992
Pubmed

Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors.

PLA2R1 C1GALT1 MSMO1 SC5D DNASE2 CLPTM1

7.26e-04145127630550785
CytobandEnsembl 112 genes in cytogenetic band chr14q21

MDGA2 PRPF39 POLE2

2.58e-0597273chr14q21
CytobandEnsembl 112 genes in cytogenetic band chr4q32

RBM46 MSMO1

2.28e-03120272chr4q32
CytobandEnsembl 112 genes in cytogenetic band chr2q24

PLA2R1 CERS6

2.55e-03127272chr2q24
CytobandEnsembl 112 genes in cytogenetic band chr10q23

MYOF LIPK

5.87e-03195272chr10q23
GeneFamilyFatty acid hydroxylase domain containing

MSMO1 SC5D

1.57e-056192552
GeneFamilyBeta 3-glycosyltransferases

C1GALT1 B3GNT5

2.85e-0424192426
CoexpressionFARMER_BREAST_CANCER_APOCRINE_VS_BASAL

CERS6 CASD1 TAF5 MSMO1 SC5D

1.94e-05329275M2631
CoexpressionGSE18804_SPLEEN_MACROPHAGE_VS_BRAIN_TUMORAL_MACROPHAGE_UP

APEX1 MYOF C1GALT1 TAF5

4.65e-05196274M10014
CoexpressionGSE360_DC_VS_MAC_B_MALAYI_HIGH_DOSE_DN

AMPD3 MSMO1 LILRB5 DNASE2

5.03e-05200274M5186
CoexpressionGSE10239_MEMORY_VS_DAY4.5_EFF_CD8_TCELL_DN

C1GALT1 CASD1 TAF5 SC5D

5.03e-05200274M3074
ToppCellSmart-start-Cell-Wel_seq-Neoplastic-Stem-like-OPC-like-OPC-like-F|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

RBM46 LIPK TEKT5 CSN1S1

5.33e-06193274315840bc48899f3a36d57b19197509de19716e3d
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22-Myeloid-Monocytic-Nonclassical_Monocyte-Mono_c4-CD14-CD16|Severe-critical_progression_d12-22 / Compartment, severity and other cell annotations on 10x 3' data (130k)

MYOF AMPD3 A2ML1

9.82e-05149273c773c2b9685ec44a35246180a93456c8765353f5
ToppCellDendritic_Cells-Donor_03|World / lung cells shred on cell class, cell subclass, sample id

APEX1 CERS6 LILRB5

1.08e-0415427365013f696da623d37f1e3447a294dfb3c31ae93b
ToppCellfacs-Lung-Endomucin-24m-Lymphocytic|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

B3GNT5 OAZ3 PITX2

1.15e-0415727314c4c61790eba6a388679e6d5011424d56cf3b5a
ToppCellfacs-Lung-Endomucin-24m-Lymphocytic-B_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

B3GNT5 OAZ3 PITX2

1.28e-041632732a561aa4518cf52d8470eff083b84f942a2b2b5d
ToppCell343B-Myeloid-Dendritic-cDC_proliferating_2|Dendritic / Donor, Lineage, Cell class and subclass (all cells)

OAZ3 LILRB5 POLE2

1.30e-04164273d7053de88ef8e42cac6726a40e72f212659ee034
ToppCelldroplet-Liver-nan-3m-Myeloid-Kupffer_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYOF AMPD3 CERS6

1.50e-04172273f814b6134ad608015765399d54cc1e5e1873ed34
ToppCellTCGA-Lung-Primary_Tumor-Lung_Carcinoma-Lung_Squamous_Cell_Carcinoma-3|TCGA-Lung / Sample_Type by Project: Shred V9

SLC6A8 PLA2R1 MRAP2

1.83e-04184273ea4ccebe2d54279fcc517e4f0bfa652b91a808bb
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Macula_Densa_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MYOF CASD1 MRAP2

1.98e-04189273e059be2965cca70ff5576df055d0af1775b76e00
ToppCellFetal_29-31_weeks-Immune-interstitial_macrophage_(C1Q_positive)-D062|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

AMPD3 B3GNT5 LILRB5

2.04e-0419127324d75b7e1d6fb9d24aa7844f584ee888a449841f
ToppCellFetal_29-31_weeks-Immune-interstitial_macrophage_(C1Q_positive)|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

AMPD3 B3GNT5 LILRB5

2.17e-04195273312d9625655b38f1a7c2bf8f8bb7b667ebdf9617
ToppCell5'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.6.2.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

B3GNT5 LILRB5 DNASE2

2.20e-041962735fe6534af65d43eeacd4b031310242b4f706008b
ToppCell368C-Fibroblasts-Fibroblast-I|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

APEX1 MSMO1 SC5D

2.24e-04197273a3d5225b2b0dd5199f3c3f86713a05d48f1be8f4
ToppCell368C-Fibroblasts-Fibroblast-I-|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

APEX1 MSMO1 SC5D

2.24e-04197273d7a10eca2d810ab87dea570676f0b7041f99f017
ToppCell(6)_Macrophage|World / shred on Cell_type and subtype

MYOF B3GNT5 LILRB5

2.24e-04197273010b275d4da4a896175ad7fbaa96d1dc11a0b744
ToppCelldistal-Epithelial-Basal-1|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

SLC6A8 A2ML1 PITX2

2.24e-0419727375b4292ce2ad7f9c8b6a4781e1cb71f5b18b74e3
ToppCellAT2_cells-Donor_03|World / lung cells shred on cell class, cell subclass, sample id

CASD1 MSMO1 SC5D

2.27e-04198273893036558a9ad86b57f9e735df35812e9d18739e
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW23-Neuronal-Neurons|GW23 / Sample Type, Dataset, Time_group, and Cell type.

APEX1 MSMO1 SC5D

2.27e-0419827390ebefc9ba8dc2a81471e5693384f5ce56f06298
ToppCell3'_v3-Lung-Myeloid_Mac|Lung / Manually curated celltypes from each tissue

MYOF B3GNT5 DNASE2

2.31e-041992731677aaee5b7f5f262e27df5d9f1bdf6e21e3d804
ToppCellNeuronal-Excitatory-eE(FEZF2_SLC17A7)|Neuronal / cells hierarchy compared to all cells using T-Statistic

MYOF MDGA2 MRAP2

2.34e-04200273501cd2b4e55444fc5fdd93ebbcfc0616442b110b
ToppCellSigmoid-(6)_Macrophage|Sigmoid / shred on region, Cell_type, and subtype

MYOF B3GNT5 LILRB5

2.34e-042002739e10cca4429de2c4c8c3c6cf2c9e28637a095be9
ToppCellmLN-(6)_Macrophage-(61)_LYVE1_Macrophage|mLN / shred on region, Cell_type, and subtype

MYOF B3GNT5 LILRB5

2.34e-04200273a20f5ec61d492d8a2adf695ec304b5d57296aa8f
ToppCellmLN-Macrophage-LYVE1_Macrophage|mLN / Region, Cell class and subclass

MYOF B3GNT5 LILRB5

2.34e-0420027389cf739a3c2f5d30e547404f2f2ec6500cd1d65d
ToppCellmLN-(6)_Macrophage|mLN / shred on region, Cell_type, and subtype

MYOF B3GNT5 LILRB5

2.34e-042002736dcba82a7d322102bae205543086e84c7655b3e0
ToppCellSigmoid-Macrophage|Sigmoid / Region, Cell class and subclass

MYOF B3GNT5 LILRB5

2.34e-04200273b07ac0ff3b8530e99094678fed80f35949cafac8
ToppCellmLN-Macrophage|mLN / Region, Cell class and subclass

MYOF B3GNT5 LILRB5

2.34e-0420027368d709afd226241e002dae6d6820bccd1cfd87a1
ToppCell(61)_LYVE1_Macrophage|World / shred on Cell_type and subtype

MYOF B3GNT5 LILRB5

2.55e-04206273711e961a9a03bfd2f0958bd14f25f7f207a2f2b5
Drug4-ketomyxol

SLC6A8 SC5D

4.06e-063272CID016061238
Drugmyxol

SLC6A8 SC5D

1.35e-055272CID016061290
DrugAC1L3M3D

SLC6A8 APEX1 SC5D

2.04e-0545273CID000091445
Drugputrescine

APEX1 OAZ3 CSN1S1 POLE2

3.05e-05153274CID000001045
Drugfluphenazine dihydrochloride; Up 200; 10uM; MCF7; HT_HG-U133A_EA

C1GALT1 CASD1 MSMO1 OAZ3

4.50e-051692741075_UP
DrugTryptophyltyrosine

APEX1 CSN1S1

4.85e-059272CID000088184
DrugPapaverine hydrochloride [61-25-6]; Down 200; 10.6uM; HL60; HG-U133A

SLC6A8 MYOF CERS6 MSMO1

5.88e-051812741755_DN
DrugKetoconazole [65277-42-1]; Down 200; 7.6uM; HL60; HT_HG-U133A

SLC6A8 MYOF AMPD3 DNASE2

5.88e-051812741285_DN
DrugA37536

APEX1 DNASE2

7.40e-0511272CID000130471
DiseaseCataract

SC5D PITX2

4.15e-0437242C0086543
Diseaseserum dimethylarginine measurement

C1GALT1 SC5D

1.20e-0363242EFO_0005418
Diseasechronic obstructive pulmonary disease

AMPD3 C1GALT1 CERS6 TEKT5

2.15e-03688244EFO_0000341
Diseasestatus epilepticus (biomarker_via_orthology)

SLC6A8 APEX1

2.99e-03100242DOID:1824 (biomarker_via_orthology)
Diseaseseasonal gut microbiome measurement

MYOF TEKT5

3.73e-03112242EFO_0007753
DiseaseDrug Use Disorders

PLA2R1 CERS6

3.93e-03115242C0013222
DiseaseDrug Dependence

PLA2R1 CERS6

3.93e-03115242C1510472
DiseaseDrug habituation

PLA2R1 CERS6

3.93e-03115242C0013170
DiseaseSubstance Dependence

PLA2R1 CERS6

3.93e-03115242C0038580
DiseaseSubstance Use Disorders

PLA2R1 CERS6

3.93e-03115242C0038586
DiseaseSubstance-Related Disorders

PLA2R1 CERS6

3.93e-03115242C0236969
DiseaseDrug abuse

PLA2R1 CERS6

3.93e-03115242C0013146
DiseaseOrganic Mental Disorders, Substance-Induced

PLA2R1 CERS6

3.93e-03115242C0029231
DiseasePrescription Drug Abuse

PLA2R1 CERS6

3.93e-03115242C4316881
DiseaseSubstance abuse problem

PLA2R1 CERS6

4.00e-03116242C0740858

Protein segments in the cluster

PeptideGeneStartEntry
FPFWYGHYPYQVAEY

A2ML1

616

A8K2U0
VYWAYDYALRVYPVP

POLE2

461

P56282
LYPNTPYAYTFWTYM

APEX1

256

P27695
VWTSEQNPPYSYYLY

AMPD3

546

Q01432
YCNKNNWAPPEYYLY

RBM46

401

Q8TBY0
TYYFTEYFNIPYDWE

MSMO1

116

Q15800
TRNYLYPIWSPYAYY

OAZ3

21

Q9UMX2
QLAAYPYAVWYYPQI

CSN1S1

141

P47710
YYYYRKNPQVWSNPS

LILRB5

196

O75023
YSAWYQYNYQNPWNY

PRPF39

646

Q86UA1
YAPEFYYDTYNPVWQ

MDGA2

631

Q7Z553
KYYVSYEMYQWPAYP

B3GNT5

236

Q9BYG0
PYQFYYFVPLVTVWF

CASD1

511

Q96PB1
YTYPWVYNYQLEGIF

DNASE2

176

O00115
WYNYPYQPLTTDLHY

CERS6

166

Q6ZMG9
PRTFWYWNYNYYPPV

C1GALT1

281

Q9NS00
YPVWDTQFSPYGYYF

TAF5

586

Q15542
YQPYYLPGYRYLNSW

TEKT5

36

Q96M29
PYDDMYPGYSYNNWA

PITX2

166

Q99697
YYEPLVYNNTYVYPW

SLC6A8

541

P48029
IPFWYQYDVPWLFYQ

PLA2R1

806

Q13018
VSGDYYPIIYFNDYW

CLPTM1

271

O96005
YTWEYEYYEIGPVSF

MRAP2

21

Q96G30
YFFTPYVYPATWPED

SC5D

11

O75845
PYADPYYDYEIERFW

ZC3H18

366

Q86VM9
SQIISYWGYPYEEYD

LIPK

36

Q5VXJ0
RAVFDGNYYYYLPWA

MYOF

621

Q9NZM1