Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	alpha-tocopherol omega-hydroxylase activity	CYP4F2 CYP4F3 CYP4F12 CYP4F11	1.13e-09	5	79	4	GO:0052871
GeneOntologyMolecularFunction	leukotriene-B4 20-monooxygenase activity	CYP4F2 CYP4F3 CYP4F12 CYP4F11	7.87e-09	7	79	4	GO:0050051
GeneOntologyMolecularFunction	alkane 1-monooxygenase activity	CYP4F2 CYP4F3 CYP4F12 CYP4F11	7.87e-09	7	79	4	GO:0018685
GeneOntologyMolecularFunction	arachidonate omega-hydroxylase activity	CYP4F2 CYP4F3 CYP4F12 CYP4F11	4.68e-08	10	79	4	GO:0052869
GeneOntologyMolecularFunction	fatty acid omega-hydroxylase activity	CYP4F2 CYP4F3 CYP4F12 CYP4F11	4.68e-08	10	79	4	GO:0120250
GeneOntologyMolecularFunction	long-chain fatty acid omega-hydroxylase activity	CYP4F2 CYP4F3 CYP4F12 CYP4F11	4.68e-08	10	79	4	GO:0102033
GeneOntologyMolecularFunction	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen	CYP4F2 CYP4F3 CYP4F12 CYP4F11	1.58e-07	13	79	4	GO:0016713
GeneOntologyMolecularFunction	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	FMO2 CYP4F2 CYP4F3 CYP4F12 CYP4F11	5.03e-07	40	79	5	GO:0016709
GeneOntologyMolecularFunction	arachidonate epoxygenase activity	CYP4F2 CYP4F3 CYP4F12 CYP4F11	2.27e-06	24	79	4	GO:0008392
GeneOntologyMolecularFunction	arachidonate monooxygenase activity	CYP4F2 CYP4F3 CYP4F12 CYP4F11	3.72e-06	27	79	4	GO:0008391
GeneOntologyMolecularFunction	aromatase activity	CYP4F2 CYP4F3 CYP4F12 CYP4F11	1.08e-05	35	79	4	GO:0070330
GeneOntologyMolecularFunction	20-hydroxy-leukotriene B4 omega oxidase activity	CYP4F2 CYP4F3	1.55e-05	2	79	2	GO:0097258
GeneOntologyMolecularFunction	20-aldehyde-leukotriene B4 20-monooxygenase activity	CYP4F2 CYP4F3	1.55e-05	2	79	2	GO:0097259
GeneOntologyMolecularFunction	arachidonate binding	CYP4F2 CYP4F12 CYP4F11	2.62e-05	15	79	3	GO:0050544
GeneOntologyMolecularFunction	icosanoid binding	CYP4F2 CYP4F12 CYP4F11	3.22e-05	16	79	3	GO:0050542
GeneOntologyMolecularFunction	icosatetraenoic acid binding	CYP4F2 CYP4F12 CYP4F11	3.22e-05	16	79	3	GO:0050543
GeneOntologyMolecularFunction	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	CYP4F2 CYP4F3 CYP4F12 CYP4F11	4.20e-05	49	79	4	GO:0016712
GeneOntologyMolecularFunction	monooxygenase activity	FMO2 CYP4F2 CYP4F3 CYP4F12 CYP4F11	9.32e-05	115	79	5	GO:0004497
GeneOntologyMolecularFunction	long-chain fatty acid binding	CYP4F2 CYP4F12 CYP4F11	1.82e-04	28	79	3	GO:0036041
GeneOntologyMolecularFunction	monocarboxylic acid binding	UGT1A4 CYP4F2 CYP4F12 CYP4F11	8.60e-04	107	79	4	GO:0033293
GeneOntologyMolecularFunction	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	FMO2 CYP4F2 CYP4F3 CYP4F12 CYP4F11	1.04e-03	194	79	5	GO:0016705
GeneOntologyMolecularFunction	calcium-dependent phospholipid binding	SYT12 SYT1 SYT2	1.73e-03	60	79	3	GO:0005544
GeneOntologyMolecularFunction	clathrin binding	SYT12 SYT1 SYT2	2.00e-03	63	79	3	GO:0030276
GeneOntologyMolecularFunction	fatty acid binding	CYP4F2 CYP4F12 CYP4F11	2.59e-03	69	79	3	GO:0005504
GeneOntologyMolecularFunction	calcium ion binding	PITPNM2 EYS CDH20 SYT12 ITLN1 TRPM2 SYT1 SYT2 CRB2	2.76e-03	749	79	9	GO:0005509
GeneOntologyMolecularFunction	phosphatidylserine binding	SYT12 SYT1 SYT2	3.04e-03	73	79	3	GO:0001786
GeneOntologyMolecularFunction	protein serine kinase activity	PIK3R4 SMG1 STK36 HIPK4 MAPK7 MAP3K6	3.16e-03	363	79	6	GO:0106310
GeneOntologyMolecularFunction	heme binding	CYP4F2 CYP4F3 CYP4F12 CYP4F11	3.26e-03	154	79	4	GO:0020037
GeneOntologyMolecularFunction	tetrapyrrole binding	CYP4F2 CYP4F3 CYP4F12 CYP4F11	4.09e-03	164	79	4	GO:0046906
GeneOntologyMolecularFunction	iron ion binding	CYP4F2 CYP4F3 CYP4F12 CYP4F11	4.27e-03	166	79	4	GO:0005506
GeneOntologyBiologicalProcess	leukotriene B4 catabolic process	CYP4F2 CYP4F3 CYP4F12 CYP4F11	3.13e-09	6	80	4	GO:0036101
GeneOntologyBiologicalProcess	leukotriene B4 metabolic process	CYP4F2 CYP4F3 CYP4F12 CYP4F11	7.28e-09	7	80	4	GO:0036102
GeneOntologyBiologicalProcess	leukotriene catabolic process	CYP4F2 CYP4F3 CYP4F12 CYP4F11	1.45e-08	8	80	4	GO:0036100
GeneOntologyBiologicalProcess	menaquinone catabolic process	CYP4F2 CYP4F12 CYP4F11	5.62e-08	3	80	3	GO:0042361
GeneOntologyBiologicalProcess	icosanoid catabolic process	CYP4F2 CYP4F3 CYP4F12 CYP4F11	6.78e-08	11	80	4	GO:1901523
GeneOntologyBiologicalProcess	long-chain fatty acid catabolic process	CYP4F2 CYP4F3 CYP4F12 CYP4F11	1.01e-07	12	80	4	GO:0042758
GeneOntologyBiologicalProcess	menaquinone metabolic process	CYP4F2 CYP4F12 CYP4F11	2.24e-07	4	80	3	GO:0009233
GeneOntologyBiologicalProcess	phylloquinone metabolic process	CYP4F2 CYP4F12 CYP4F11	2.24e-07	4	80	3	GO:0042374
GeneOntologyBiologicalProcess	phylloquinone catabolic process	CYP4F2 CYP4F12 CYP4F11	2.24e-07	4	80	3	GO:0042376
GeneOntologyBiologicalProcess	vitamin K catabolic process	CYP4F2 CYP4F12 CYP4F11	2.24e-07	4	80	3	GO:0042377
GeneOntologyBiologicalProcess	prostaglandin catabolic process	CYP4F2 CYP4F12 CYP4F11	1.11e-06	6	80	3	GO:1905344
GeneOntologyBiologicalProcess	prostanoid catabolic process	CYP4F2 CYP4F12 CYP4F11	1.11e-06	6	80	3	GO:0062232
GeneOntologyBiologicalProcess	fatty acid derivative catabolic process	CYP4F2 CYP4F3 CYP4F12 CYP4F11	1.46e-06	22	80	4	GO:1901569
GeneOntologyBiologicalProcess	vitamin K metabolic process	CYP4F2 CYP4F12 CYP4F11	9.07e-06	11	80	3	GO:0042373
GeneOntologyBiologicalProcess	organic hydroxy compound catabolic process	CYP4F2 CYP4F3 CYP4F12 ALDH2 CYP4F11	9.45e-06	73	80	5	GO:1901616
GeneOntologyBiologicalProcess	fat-soluble vitamin catabolic process	CYP4F2 CYP4F12 CYP4F11	1.21e-05	12	80	3	GO:0042363
GeneOntologyBiologicalProcess	leukotriene metabolic process	CYP4F2 CYP4F3 CYP4F12 CYP4F11	1.90e-05	41	80	4	GO:0006691
GeneOntologyBiologicalProcess	omega-hydroxylase P450 pathway	CYP4F2 CYP4F12 CYP4F11	1.98e-05	14	80	3	GO:0097267
GeneOntologyBiologicalProcess	vitamin catabolic process	CYP4F2 CYP4F12 CYP4F11	4.40e-05	18	80	3	GO:0009111
GeneOntologyBiologicalProcess	fat-soluble vitamin metabolic process	UGT1A4 CYP4F2 CYP4F12 CYP4F11	4.56e-05	51	80	4	GO:0006775
GeneOntologyBiologicalProcess	ketone catabolic process	CYP4F2 CYP4F12 CYP4F11	7.11e-05	21	80	3	GO:0042182
GeneOntologyBiologicalProcess	arachidonate metabolic process	CYP4F2 CYP4F3 CYP4F12 CYP4F11	1.41e-04	68	80	4	GO:0019369
GeneOntologyBiologicalProcess	catechol-containing compound biosynthetic process	KL ALDH2 HDC	1.91e-04	29	80	3	GO:0009713
GeneOntologyBiologicalProcess	catecholamine biosynthetic process	KL ALDH2 HDC	1.91e-04	29	80	3	GO:0042423
GeneOntologyBiologicalProcess	vitamin E metabolic process	CYP4F2 CYP4F12	2.21e-04	6	80	2	GO:0042360
GeneOntologyBiologicalProcess	fatty acid derivative metabolic process	CYP4F2 CYP4F3 CYP4F12 CYP4F11	2.92e-04	82	80	4	GO:1901568
GeneOntologyBiologicalProcess	biogenic amine biosynthetic process	KL ALDH2 HDC	8.06e-04	47	80	3	GO:0042401
GeneOntologyBiologicalProcess	organic hydroxy compound metabolic process	UGT1A4 ABHD4 KL CYP4F2 CYP4F3 CYP4F12 ALDH2 CYP4F11 HDC	8.30e-04	641	80	9	GO:1901615
GeneOntologyBiologicalProcess	amine biosynthetic process	KL ALDH2 HDC	8.57e-04	48	80	3	GO:0009309
Domain	LAM_G_DOMAIN	COL5A1 EYS NRXN3 LAMA5 CRB2	5.36e-07	38	79	5	PS50025
Domain	Laminin_G_2	COL5A1 EYS NRXN3 LAMA5 CRB2	6.98e-07	40	79	5	PF02210
Domain	LamG	COL5A1 EYS NRXN3 LAMA5 CRB2	1.14e-06	44	79	5	SM00282
Domain	Laminin_G	COL5A1 EYS NRXN3 LAMA5 CRB2	4.58e-06	58	79	5	IPR001791
Domain	Synaptotagmin1	SYT1 SYT2	1.77e-05	2	79	2	IPR015428
Domain	Cyt_P450_E_grp-I	CYP4F2 CYP4F3 CYP4F12 CYP4F11	3.87e-05	45	79	4	IPR002401
Domain	ConA-like_dom	COL5A1 EYS RNF123 NRXN3 LAMA5 SPSB3 CRB2	3.92e-05	219	79	7	IPR013320
Domain	-	COL5A1 EYS NRXN3 LAMA5 CRB2	5.13e-05	95	79	5	2.60.120.200
Domain	Cyt_P450_CS	CYP4F2 CYP4F3 CYP4F12 CYP4F11	7.42e-05	53	79	4	IPR017972
Domain	Synaptotagmin	SYT12 SYT1 SYT2	7.88e-05	20	79	3	IPR001565
Domain	CYTOCHROME_P450	CYP4F2 CYP4F3 CYP4F12 CYP4F11	9.88e-05	57	79	4	PS00086
Domain	-	CYP4F2 CYP4F3 CYP4F12 CYP4F11	1.06e-04	58	79	4	1.10.630.10
Domain	p450	CYP4F2 CYP4F3 CYP4F12 CYP4F11	1.06e-04	58	79	4	PF00067
Domain	Cyt_P450	CYP4F2 CYP4F3 CYP4F12 CYP4F11	1.21e-04	60	79	4	IPR001128
Domain	EGF-like_dom	EYS NRXN3 TENM3 LAMA5 CRB2 OTOG	6.52e-04	249	79	6	IPR000742
Domain	Kelch	KLHL34 KLHDC8B KLHL17	1.90e-03	58	79	3	SM00612
Domain	EGF_3	EYS NRXN3 TENM3 CRB2 OTOG	3.20e-03	235	79	5	PS50026
Domain	EGF	EYS NRXN3 TENM3 LAMA5 CRB2	3.20e-03	235	79	5	SM00181
Domain	Kelch_1	KLHL34 KLHDC8B KLHL17	3.25e-03	70	79	3	PF01344
Domain	Kelch_1	KLHL34 KLHDC8B KLHL17	3.25e-03	70	79	3	IPR006652
Domain	EGF_1	EYS NRXN3 TENM3 LAMA5 CRB2	4.52e-03	255	79	5	PS00022
Pathway	REACTOME_EICOSANOIDS	CYP4F2 CYP4F3 CYP4F12 CYP4F11	8.62e-08	12	53	4	M27129
Pathway	REACTOME_EICOSANOIDS	CYP4F2 CYP4F3 CYP4F12 CYP4F11	8.62e-08	12	53	4	MM14845
Pathway	WP_EICOSANOID_METABOLISM_VIA_CYTOCHROME_P450_MONOOXYGENASES	CYP4F2 CYP4F3 CYP4F12 CYP4F11	1.73e-07	14	53	4	MM15842
Pathway	REACTOME_FATTY_ACIDS	CYP4F2 CYP4F3 CYP4F12 CYP4F11	2.36e-07	15	53	4	M27126
Pathway	REACTOME_MISCELLANEOUS_SUBSTRATES	CYP4F2 CYP4F3 CYP4F12 CYP4F11	5.24e-07	18	53	4	MM14843
Pathway	REACTOME_FATTY_ACIDS	CYP4F2 CYP4F3 CYP4F12 CYP4F11	5.24e-07	18	53	4	MM14841
Pathway	REACTOME_SYNTHESIS_OF_LEUKOTRIENES_LT_AND_EOXINS_EX	CYP4F2 CYP4F3 CYP4F12 CYP4F11	2.12e-06	25	53	4	MM14858
Pathway	REACTOME_PHASE_I_FUNCTIONALIZATION_OF_COMPOUNDS	FMO2 CYP4F2 CYP4F3 CYP4F12 ALDH2 CYP4F11	2.42e-06	104	53	6	M738
Pathway	REACTOME_PHASE_I_FUNCTIONALIZATION_OF_COMPOUNDS	FMO2 CYP4F2 CYP4F3 CYP4F12 ALDH2 CYP4F11	2.56e-06	105	53	6	MM14842
Pathway	WP_EICOSANOID_METABOLISM_VIA_CYCLOOXYGENASES_COX	CYP4F2 CYP4F3 CYP4F12 CYP4F11	6.72e-06	33	53	4	MM15918
Pathway	WP_EICOSANOID_METABOLISM_VIA_LIPOXYGENASES_LOX	CYP4F2 CYP4F3 CYP4F12 CYP4F11	6.72e-06	33	53	4	MM15963
Pathway	REACTOME_SYNTHESIS_OF_16_20_HYDROXYEICOSATETRAENOIC_ACIDS_HETE	CYP4F2 CYP4F12 CYP4F11	8.11e-06	11	53	3	MM14863
Pathway	REACTOME_MISCELLANEOUS_SUBSTRATES	CYP4F2 CYP4F3 CYP4F11	1.08e-05	12	53	3	M27128
Pathway	REACTOME_BIOLOGICAL_OXIDATIONS	UGT1A4 FMO2 CYP4F2 CYP4F3 CYP4F12 ALDH2 CYP4F11	1.67e-05	219	53	7	MM14838
Pathway	REACTOME_BIOLOGICAL_OXIDATIONS	UGT1A4 FMO2 CYP4F2 CYP4F3 CYP4F12 ALDH2 CYP4F11	1.72e-05	220	53	7	M10320
Pathway	WP_TRYPTOPHAN_METABOLISM	CYP4F2 CYP4F12 ALDH2 CYP4F11	3.07e-05	48	53	4	MM15902
Pathway	REACTOME_NEUREXINS_AND_NEUROLIGINS	NRXN3 SYT12 SYT1 SYT2	5.66e-05	56	53	4	M27616
Pathway	WP_METAPATHWAY_BIOTRANSFORMATION_PHASE_I_AND_II	UGT1A4 FMO2 CYP4F2 CYP4F3 CYP4F12 CYP4F11	6.10e-05	183	53	6	M39588
Pathway	REACTOME_SYNTHESIS_OF_LEUKOTRIENES_LT_AND_EOXINS_EX	CYP4F2 CYP4F3 CYP4F11	6.36e-05	21	53	3	M27137
Pathway	REACTOME_ARACHIDONIC_ACID_METABOLISM	CYP4F2 CYP4F3 CYP4F12 CYP4F11	7.93e-05	61	53	4	MM14861
Pathway	WP_OXIDATION_BY_CYTOCHROME_P450	CYP4F2 CYP4F3 CYP4F12 CYP4F11	8.45e-05	62	53	4	M39653
Pathway	REACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE	CYP4F2 CYP4F3 CYP4F12 CYP4F11	9.57e-05	64	53	4	M5650
Pathway	REACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE	CYP4F2 CYP4F3 CYP4F12 CYP4F11	1.08e-04	66	53	4	MM14839
Pathway	WP_HIPPOCAMPAL_SYNAPTOGENESIS_AND_NEUROGENESIS	NRXN3 SYT12 SYT2	1.38e-04	27	53	3	M45550
Pathway	REACTOME_PROTEIN_PROTEIN_INTERACTIONS_AT_SYNAPSES	NRXN3 SYT12 SYT1 SYT2	3.15e-04	87	53	4	M27617
Pathway	WP_EICOSANOID_METABOLISM_VIA_CYTOCHROME_P450_MONOOXYGENASES_PATHWAY	CYP4F2 CYP4F12	4.91e-04	9	53	2	M39819
Pathway	REACTOME_NEUROTOXICITY_OF_CLOSTRIDIUM_TOXINS	SYT1 SYT2	6.12e-04	10	53	2	M27018
Pathway	REACTOME_ARACHIDONIC_ACID_METABOLISM	CYP4F2 CYP4F3 CYP4F11	1.41e-03	59	53	3	M27140
Pathway	WP_ANGIOPOIETINLIKE_PROTEIN_8_REGULATORY_PATHWAY	PIK3R4 NR1H3 MAPK7 MAP3K6	1.51e-03	132	53	4	M39338
Pubmed	Omega oxidation of 3-hydroxy fatty acids by the human CYP4F gene subfamily enzyme CYP4F11.	CYP4F2 CYP4F3 CYP4F12 CYP4F11	2.59e-11	4	80	4	18065749
Pubmed	The cytochrome P450 4 (CYP4) family.	CYP4F2 CYP4F3 CYP4F12 CYP4F11	3.88e-10	6	80	4	9068972
Pubmed	Disruption of mouse cytochrome p450 4f14 (Cyp4f14 gene) causes severe perturbations in vitamin E metabolism.	CYP4F2 CYP4F12 CYP4F11	4.68e-08	4	80	3	22665481
Pubmed	Expression and catalytic activity of mouse leukotriene B4 omega-hydroxylase, CYP4F14.	CYP4F2 CYP4F12 CYP4F11	4.68e-08	4	80	3	11185557
Pubmed	Disruption of P450-mediated vitamin E hydroxylase activities alters vitamin E status in tocopherol supplemented mice and reveals extra-hepatic vitamin E metabolism.	CYP4F2 CYP4F12 CYP4F11	1.17e-07	5	80	3	22969154
Pubmed	Cytochrome P4504f, a potential therapeutic target limiting neuroinflammation.	CYP4F2 CYP4F12 CYP4F11	1.17e-07	5	80	3	21466787
Pubmed	Role of ω-hydroxylase in adenosine-mediated aortic response through MAP kinase using A2A-receptor knockout mice.	CYP4F2 CYP4F12 CYP4F11	4.07e-07	7	80	3	22160543
Pubmed	Distinct developmental expression of synaptotagmin I and IX in the mouse brain.	SYT12 SYT1 SYT2	9.75e-07	9	80	3	16407767
Pubmed	Cytochrome P450-dependent catabolism of vitamin K: ω-hydroxylation catalyzed by human CYP4F2 and CYP4F11.	CYP4F2 CYP4F11	5.23e-06	2	80	2	24138531
Pubmed	Expression of CYP4F2 in human liver and kidney: assessment using targeted peptide antibodies.	CYP4F2 CYP4F12	5.23e-06	2	80	2	18662666
Pubmed	Expression and physiological function of CYP4F subfamily in human eosinophils.	CYP4F3 CYP4F12	5.23e-06	2	80	2	17980168
Pubmed	Cloning and expression of a novel form of leukotriene B4 omega-hydroxylase from human liver.	CYP4F2 CYP4F3	5.23e-06	2	80	2	8026587
Pubmed	Synaptotagmins I and II mediate entry of botulinum neurotoxin B into cells.	SYT1 SYT2	5.23e-06	2	80	2	14504267
Pubmed	Expression of TMEM207 in Colorectal Cancer: Relation between TMEM207 and Intelectin-1.	ITLN1 TMEM207	5.23e-06	2	80	2	26819645
Pubmed	The N-terminal half of the heavy chain of botulinum type A neurotoxin forms channels in planar phospholipid bilayers.	SYT1 SYT2	5.23e-06	2	80	2	2446925
Pubmed	Synaptotagmins 1 and 2 as mediators of rapid exocytosis at nerve terminals: the dyad hypothesis.	SYT1 SYT2	5.23e-06	2	80	2	23648184
Pubmed	Inositol-1,3,4,5-tetrakisphosphate binding to C2B domain of IP4BP/synaptotagmin II.	SYT1 SYT2	5.23e-06	2	80	2	7961887
Pubmed	Synaptotagmins I and II act as nerve cell receptors for botulinum neurotoxin G.	SYT1 SYT2	5.23e-06	2	80	2	15123599
Pubmed	Expression and characterization of human cytochrome P450 4F11: Putative role in the metabolism of therapeutic drugs and eicosanoids.	CYP4F3 CYP4F11	5.23e-06	2	80	2	15364545
Pubmed	Synaptotagmin I and II are present in distinct subsets of central synapses.	SYT1 SYT2	5.23e-06	2	80	2	17492637
Pubmed	Synaptotagmin2 (Syt2) Drives Fast Release Redundantly with Syt1 at the Output Synapses of Parvalbumin-Expressing Inhibitory Neurons.	SYT1 SYT2	5.23e-06	2	80	2	28363983
Pubmed	Human SCAMP5, a novel secretory carrier membrane protein, facilitates calcium-triggered cytokine secretion by interaction with SNARE machinery.	SYT1 SYT2	1.57e-05	3	80	2	19234194
Pubmed	Human CYP4F3s are the main catalysts in the oxidation of fatty acid epoxides.	CYP4F2 CYP4F3	1.57e-05	3	80	2	15145985
Pubmed	Synaptotagmin interaction with the syntaxin/SNAP-25 dimer is mediated by an evolutionarily conserved motif and is sensitive to inositol hexakisphosphate.	SYT1 SYT2	1.57e-05	3	80	2	14709554
Pubmed	Mechanism of botulinum neurotoxin B and G entry into hippocampal neurons.	SYT1 SYT2	1.57e-05	3	80	2	18158333
Pubmed	Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants.	CYP4F2 CYP4F3 CYP4F12 CYP4F11	2.12e-05	70	80	4	15128046
Pubmed	Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition.	NR2C2 HIPK4 NR1H3 KLHL34 MAPK7 MAP3K6 SPSB3	2.46e-05	372	80	7	22939624
Pubmed	Different effects on fast exocytosis induced by synaptotagmin 1 and 2 isoforms and abundance but not by phosphorylation.	SYT1 SYT2	3.13e-05	4	80	2	16407561
Pubmed	Zea mays annexins modulate cytosolic free Ca2+ and generate a Ca2+-permeable conductance.	SYT1 SYT2	3.13e-05	4	80	2	19234085
Pubmed	Identification of curcumin-inhibited extracellular matrix receptors in non-small cell lung cancer A549 cells by RNA sequencing.	COL5A1 LAMA5	3.13e-05	4	80	2	28618934
Pubmed	Control of exocytosis by synaptotagmins and otoferlin in auditory hair cells.	SYT1 SYT2	3.13e-05	4	80	2	20926654
Pubmed	A Synaptotagmin Isoform Switch during the Development of an Identified CNS Synapse.	SYT1 SYT2	3.13e-05	4	80	2	27210552
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	VWA5B2 ZXDC PITPNM2 STK36 NUP85 LAMA5 CHD8 TANC1 PLEC MAPKBP1 KLHL17	4.48e-05	1105	80	11	35748872
Pubmed	NSD3-Short Is an Adaptor Protein that Couples BRD4 to the CHD8 Chromatin Remodeler.	BPTF CHD8	5.20e-05	5	80	2	26626481
Pubmed	A third synaptotagmin gene, Syt3, in the mouse.	SYT1 SYT2	5.20e-05	5	80	2	8058779
Pubmed	Cytochromes P450 from family 4 are the main omega hydroxylating enzymes in humans: CYP4F3B is the prominent player in PUFA metabolism.	CYP4F2 CYP4F3	5.20e-05	5	80	2	18577768
Pubmed	Synaptotagmin-2, and -1, linked to neurotransmission impairment and vulnerability in Spinal Muscular Atrophy.	SYT1 SYT2	5.20e-05	5	80	2	28173138
Pubmed	Association of polymorphisms in nicotinic acetylcholine receptor alpha 4 subunit gene (CHRNA4), mu-opioid receptor gene (OPRM1), and ethanol-metabolizing enzyme genes with alcoholism in Korean patients.	ALDH2 CHRNA4	7.79e-05	6	80	2	15902904
Pubmed	Phospholipid composition dependence of Ca2+-dependent phospholipid binding to the C2A domain of synaptotagmin IV.	SYT1 SYT2	7.79e-05	6	80	2	8626542
Pubmed	Control of plasma membrane lipid homeostasis by the extended synaptotagmins.	SYT1 SYT2	7.79e-05	6	80	2	27065097
Pubmed	PRRT2 Is a Key Component of the Ca(2+)-Dependent Neurotransmitter Release Machinery.	SYT1 SYT2	1.09e-04	7	80	2	27052163
Pubmed	Synaptotagmin genes on mouse chromosomes 1, 7, and 10 and human chromosome 19.	SYT1 SYT2	1.09e-04	7	80	2	7749232
Pubmed	Galectin-1 stimulates motility of human umbilical cord blood-derived mesenchymal stem cells by downregulation of smad2/3-dependent collagen 3/5 and upregulation of NF-κB-dependent fibronectin/laminin 5 expression.	COL5A1 LAMA5	1.45e-04	8	80	2	24503541
Pubmed	Stonin 2: an adaptor-like protein that interacts with components of the endocytic machinery.	SYT1 SYT2	1.45e-04	8	80	2	11381094
Pubmed	Molecular determinants of crosstalk between nuclear receptors and toll-like receptors.	SYT1 NR1H3	1.45e-04	8	80	2	16143103
Pubmed	WNK1 phosphorylates synaptotagmin 2 and modulates its membrane binding.	SYT1 SYT2	1.45e-04	8	80	2	15350218
Pubmed	Comparative expression profiling of 40 mouse cytochrome P450 genes in embryonic and adult tissues.	CYP4F2 CYP4F12 CYP4F11	1.45e-04	44	80	3	12745259
Pubmed	TAF4, a subunit of transcription factor II D, directs promoter occupancy of nuclear receptor HNF4A during post-natal hepatocyte differentiation.	CYP4F2 CYP4F12 CYP4F11	1.66e-04	46	80	3	25209997
Pubmed	Tuning of Glutamate, But Not GABA, Release by an Intrasynaptic Vesicle APP Domain Whose Function Can Be Modulated by β- or α-Secretase Cleavage.	SYT12 SYT1 SYT2	1.77e-04	47	80	3	31235642
Pubmed	Plakin proteins are coordinately cleaved during apoptosis but preferentially through the action of different caspases.	CASP9 PLEC	1.86e-04	9	80	2	15500642
Pubmed	Mirror image motifs mediate the interaction of the COOH terminus of multiple synaptotagmins with the neurexins and calmodulin.	SYT1 SYT2	1.86e-04	9	80	2	8901523
Pubmed	Transcriptome analysis of mouse stem cells and early embryos.	ABHD4 BPTF LAMA5 PLEC PJA1 KLHL17	1.95e-04	363	80	6	14691545
Pubmed	Molecular mechanisms and regulation of insulin exocytosis as a paradigm of endocrine secretion.	SYT1 SYT2	2.32e-04	10	80	2	9914469
Pubmed	The secretory granule-associated protein CAPS2 regulates neurotrophin release and cell survival.	SYT1 SYT2	2.32e-04	10	80	2	14715936
Pubmed	SYNCRIP, a cytoplasmic counterpart of heterogeneous nuclear ribonucleoprotein R, interacts with ubiquitous synaptotagmin isoforms.	SYT1 SYT2	2.84e-04	11	80	2	10734137
Pubmed	Genome-wide association scan of the time to onset of attention deficit hyperactivity disorder.	SYT1 CHRNA4	4.01e-04	13	80	2	18937294
Pubmed	Cell cycle and adhesion defects in mice carrying a targeted deletion of the integrin beta4 cytoplasmic domain.	LAMA5 PLEC	4.01e-04	13	80	2	9670011
Pubmed	Genomic analysis of synaptotagmin genes.	SYT12 SYT2	4.01e-04	13	80	2	11543631
Pubmed	Loss of all 3 Extended Synaptotagmins does not affect normal mouse development, viability or fertility.	SYT1 SYT2	4.67e-04	14	80	2	27399837
Pubmed	Multiple variable first exons: a mechanism for cell- and tissue-specific gene regulation.	UGT1A4 PLEC	4.67e-04	14	80	2	14672974
Pubmed	SYT14L, especially its C2 domain, is involved in regulating melanocyte differentiation.	SYT1 SYT2	5.38e-04	15	80	2	23999003
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	PITPNM2 ANKRD44 COL5A1 BPTF B3GALNT2 LRRC27 TRPM2 TANC1 SYT2 CYP4F11 ZNF44	5.93e-04	1489	80	11	28611215
Pubmed	Role of topoisomerase IIbeta in the expression of developmentally regulated genes.	TENM3 SYT1	6.14e-04	16	80	2	16923961
Pubmed	Chromatin boundaries require functional collaboration between the hSET1 and NURF complexes.	BPTF CHD8	6.95e-04	17	80	2	21653943
Pubmed	Defective transcription initiation causes postnatal growth failure in a mouse model of nucleotide excision repair (NER) progeria.	CYP4F2 CYP4F12 CYP4F11	7.30e-04	76	80	3	22323595
Pubmed	USF1 recruits histone modification complexes and is critical for maintenance of a chromatin barrier.	BPTF CHD8	7.81e-04	18	80	2	17846119
Pubmed	USP10 deubiquitinates Tau, mediating its aggregation.	NR2C2 LAMA5	7.81e-04	18	80	2	35987808
Pubmed	Defective neuromuscular synaptogenesis in agrin-deficient mutant mice.	SYT1 SYT2	7.81e-04	18	80	2	8653788
Pubmed	A genome-wide assessment of variability in human serum metabolism.	UGT1A4 CYP4F2	8.71e-04	19	80	2	23281178
Pubmed	Genetic mapping of five mouse genes encoding synaptotagmins.	SYT1 SYT2	8.71e-04	19	80	2	8747928
Pubmed	A year of COVID-19 GWAS results from the GRASP portal reveals potential genetic risk factors.	TENM3 SYT1	9.66e-04	20	80	2	35224516
Pubmed	Age of onset of amyotrophic lateral sclerosis is modulated by a locus on 1p34.1.	STK36 NRXN3	1.07e-03	21	80	2	22959728
Pubmed	Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q.	SMG1 SCO2 DNAH3	1.27e-03	92	80	3	10493829
Pubmed	Common genetic variants associated with cognitive performance identified using the proxy-phenotype method.	PITPNM2 RNF123 MAPKBP1	1.35e-03	94	80	3	25201988
Pubmed	Cytoplasmic Metadherin (MTDH) provides survival advantage under conditions of stress by acting as RNA-binding protein.	ZXDC RNF123 LAMA5 PLEC	1.53e-03	214	80	4	22199357
Pubmed	Rescue of neuropsychiatric phenotypes in a mouse model of 16p11.2 duplication syndrome by genetic correction of an epilepsy network hub.	NRXN3 SYT12 SYT1 SYT2	1.56e-03	215	80	4	36808153
Pubmed	Congenital Myasthenic Syndromes Overview	SYT2 PLEC	1.64e-03	26	80	2	20301347
Pubmed	Redundant functions of RIM1alpha and RIM2alpha in Ca(2+)-triggered neurotransmitter release.	SYT1 SYT2	1.64e-03	26	80	2	17124501
Pubmed	LuTHy: a double-readout bioluminescence-based two-hybrid technology for quantitative mapping of protein-protein interactions in mammalian cells.	NRXN3 SYT12 SYT1 CASP9	1.66e-03	219	80	4	29997244
Pubmed	Placentation defects are highly prevalent in embryonic lethal mouse mutants.	SMG1 SYT1 CRB2	1.76e-03	103	80	3	29539633
Pubmed	Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.	NRXN3 LAMA5 MAPKBP1	1.86e-03	105	80	3	9628581
Pubmed	Differential expression of paralog RNA binding proteins establishes a dynamic splicing program required for normal cerebral cortex development.	NRXN3 CHD8	1.90e-03	28	80	2	38324473
Pubmed	Basement membrane assembly of the integrin α8β1 ligand nephronectin requires Fraser syndrome-associated proteins.	COL5A1 LAMA5	2.04e-03	29	80	2	22613833
Pubmed	Feedback regulation of p38 activity via ATF2 is essential for survival of embryonic liver cells.	CASP9 MAP3K6	2.18e-03	30	80	2	17699753
Interaction	DNAH3 interactions	DNAH3 RNF123 PLEC	1.15e-05	12	77	3	int:DNAH3
Interaction	CDH20 interactions	RNF123 CDH20	1.44e-05	2	77	2	int:CDH20
Cytoband	20q13.2-q13.3	LAMA5 CHRNA4	2.99e-05	5	80	2	20q13.2-q13.3
Cytoband	Ensembl 112 genes in cytogenetic band chr19p13	CYP4F2 CYP4F3 CYP4F12 PCSK4 CYP4F11 ZNF441 ZNF44 ZNF563	7.68e-05	797	80	8	chr19p13
Cytoband	Xp22.12	BCLAF3 KLHL34	8.34e-05	8	80	2	Xp22.12
Cytoband	19p13.2	CYP4F3 ZNF441 ZNF44 ZNF563	7.09e-04	229	80	4	19p13.2
Cytoband	3p21.31	C3orf62 PRSS45P KLHDC8B	7.29e-04	100	80	3	3p21.31
Cytoband	16p12.3	SMG1 DNAH3	1.62e-03	34	80	2	16p12.3
Cytoband	Ensembl 112 genes in cytogenetic band chr3p21	RNF123 C3orf62 PRSS45P KLHDC8B	2.31e-03	316	80	4	chr3p21
Cytoband	19p13.1	CYP4F12 CYP4F11	3.21e-03	48	80	2	19p13.1
Cytoband	10q26.3	LRRC27 CFAP46	3.62e-03	51	80	2	10q26.3
GeneFamily	Cytochrome P450 family 4	CYP4F2 CYP4F3 CYP4F12 CYP4F11	3.62e-06	36	53	4	1003
GeneFamily	Synaptotagmins	SYT12 SYT1 SYT2	1.57e-05	17	53	3	765
ToppCell	3'-Adult-SmallIntestine-Epithelial-epithelial_progenitor_cell\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MED18 ATG9B KL CCNP SSUH2	1.31e-05	168	80	5	4e2e4c88ada772e9ba6e72c9ae3a05c063e93318
ToppCell	3'-Adult-SmallIntestine-Epithelial-epithelial_progenitor_cell-TA\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MED18 ATG9B KL CCNP SSUH2	1.31e-05	168	80	5	ee4dab089adef2f47a9d39d91934523331a8b81c
ToppCell	PND07-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP2-CAP2_prolif\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	VWA5B2 PITPNM2 SYT1 TANC1 SSUH2	1.35e-05	169	80	5	8a6d05b5d60b2b2e43a8ff7521feb79cd6dbd940
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.0.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DNAH3 DZIP1L PCSK4 CFAP46 SSUH2	1.35e-05	169	80	5	14aadc2d1bf66eb47dac33b4d61ddb3c942caa4f
ToppCell	PND28-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC-VEC_mature\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	KL KCNT2 C3orf62 LRRC27 SLC43A3	1.47e-05	172	80	5	fc092a0631555d79e00ef9890cbd806e15bca2d4
ToppCell	PND28-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	KL KCNT2 C3orf62 LRRC27 SLC43A3	1.47e-05	172	80	5	745725bd10c82017d678463b8fef0d2dcf09a8fd
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Multiciliated_(nasal)-Multiciliated_(nasal)_L.0.3.1.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	STK36 DNAH3 ATG9B DZIP1L CFAP46	1.73e-05	178	80	5	3b12db04006db6e94fc45649a4b3a63b92f21a61
ToppCell	-Myositis-ILD_01\|World / lung cells shred on cell class, cell subclass, sample id	COL5A1 TENM3 ITLN1 CRB2 HDC	1.88e-05	181	80	5	ef579e958f334da0f9415aa7e3d5c02c807954a6
ToppCell	368C-Epithelial_cells-Epithelial-G_(Club-Clara_cells)-\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	FMO2 NUP85 B3GALNT2 LAMA5 MAPKBP1	2.14e-05	186	80	5	77bebf576eb9b96ecb4fefb8a82a31aaaa917fc0
ToppCell	368C-Epithelial_cells-Epithelial-G_(Club-Clara_cells)\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	FMO2 NUP85 B3GALNT2 LAMA5 MAPKBP1	2.14e-05	186	80	5	13bc41c60fd628af31899a5e8b480e06cc4781be
ToppCell	PCW_07-8.5-Mesenchymal-Mesenchymal_fibroblastic-mes_mesothelial_(19)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	NRXN3 CDH20 ITLN1 LAMA5 CRB2	2.20e-05	187	80	5	8e8f1f2a78ac5f13a414fd448af7d7ff1ea86f0f
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_1\|Adult / Lineage, Cell type, age group and donor	FMO2 KCNT2 LAMA5 SYT1 TANC1	2.20e-05	187	80	5	77f78aec946bc6bd85c29aee9ca978ce49f853a3
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	NRXN3 KCNT2 TENM3 SYT1 TANC1	2.62e-05	194	80	5	90efdbd7f1c85fd7fd622b10340250b1d8fc1197
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	NRXN3 KCNT2 TENM3 SYT1 TANC1	2.62e-05	194	80	5	df82cce5ebeb73740b02cf816c6df82253cfd566
ToppCell	Bronchial-NucSeq-Stromal-Mesofibroblastic\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	TENM3 ITLN1 MAPK7 CYP4F11 KLHL17	2.75e-05	196	80	5	96e5c6d155273e82ebafa180df8bb589c3e3e54e
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	NRXN3 KCNT2 TENM3 SYT1 TANC1	2.75e-05	196	80	5	2b36b9a40fe415917afccff99ad9c3474e087d0d
ToppCell	Bronchial-NucSeq-Stromal-Mesofibroblastic-Mesothelia\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	TENM3 ITLN1 MAPK7 CYP4F11 KLHL17	2.75e-05	196	80	5	ce13af36fc2932e8125013041742593ff3d07e86
ToppCell	COVID-19-COVID-19_Mild-Myeloid-immature_Neutrophil\|COVID-19_Mild / Disease, condition lineage and cell class	SCO2 DNAH3 SLC26A8 CYP4F3 TANC1	2.96e-05	199	80	5	e222b90caf45904d8f763574e7b6aac13333df92
ToppCell	Neuronal-Inhibitory-iB-iB_4(SST)-ADGRG6-\|Neuronal / cells hierarchy compared to all cells using T-Statistic	ANKRD44 EYS NRXN3 TENM3 TANC1	3.03e-05	200	80	5	a9cdddc4e985dae59521e557479c24fcc2ac727d
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Neuron-Neuron\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	VWA5B2 SLC26A8 NRXN3 HTR1E SYT1	3.03e-05	200	80	5	2f481e2fd248c02a5aa2e0248c16808df142fed2
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Neuron-Neuron-F\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	VWA5B2 SLC26A8 NRXN3 HTR1E SYT1	3.03e-05	200	80	5	bd4b9f6b37f4a3c960c4149cf0cfd2caf3327d2d
ToppCell	Neuronal-Inhibitory-iB-iB_4(SST)-ADGRG6--L3-5\|Neuronal / cells hierarchy compared to all cells using T-Statistic	ANKRD44 EYS NRXN3 TENM3 TANC1	3.03e-05	200	80	5	33b9199e0dfc267e2cea20b82d1c167f8adcc635
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Neuron\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	VWA5B2 SLC26A8 NRXN3 HTR1E SYT1	3.03e-05	200	80	5	dc674124475edf83908b51a4e1454bc2dc4f06fa
ToppCell	Neuronal-Inhibitory-iB-iB_4(SST)-ADGRG6\|Neuronal / cells hierarchy compared to all cells using T-Statistic	ANKRD44 EYS NRXN3 TENM3 TANC1	3.03e-05	200	80	5	9719fabddc34051949468a7520289e3c750de4f8
ToppCell	Neuronal-Inhibitory-iB\|Neuronal / cells hierarchy compared to all cells using T-Statistic	ANKRD44 EYS NRXN3 TENM3 TANC1	3.03e-05	200	80	5	45ddc5ef2caa87ada88327b63ba9b150a6bb3aa5
ToppCell	TCGA-Testes-Primary_Tumor-Testicular_Germ_Cell_Tumor-Non-Seminoma-_Embryonal_Carcinoma-1\|TCGA-Testes / Sample_Type by Project: Shred V9	PITPNM2 ATG9B CCNP KLF17	9.98e-05	134	80	4	d80c9168acbd316761330d29e994e7f9a30ad945
ToppCell	TCGA-Testes-Primary_Tumor-Testicular_Germ_Cell_Tumor-Non-Seminoma-_Embryonal_Carcinoma\|TCGA-Testes / Sample_Type by Project: Shred V9	PITPNM2 ATG9B CCNP KLF17	1.15e-04	139	80	4	6b58d01ce9d9ac23434333f9faf1bb0eef14ba90
ToppCell	E18.5-samps-Epithelial-Alveolar_epithelial-AT1_-_meso\|E18.5-samps / Age Group, Lineage, Cell class and subclass	STK36 KL LAMA5 PRSS45P	1.25e-04	142	80	4	77fd145c1c500d580f70ac4e54c3fd879ecf0ab3
ToppCell	Frontal_cortex-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	ATG9B LRRC27 SYT2 CFAP46	1.35e-04	145	80	4	8b13b576fd2e6e33ccb146860a91a53cee0cdd4d
ToppCell	TCGA-Brain-Primary_Tumor-Low_Grade_Glioma-Oligodendroglioma-4\|TCGA-Brain / Sample_Type by Project: Shred V9	SLC26A8 NPBWR2 HTR1E HIPK4	1.39e-04	146	80	4	632f52780607c638b5d3dd3fb9251c719f162a35
ToppCell	facs-Large_Intestine-Proximal-3m-Epithelial-Goblet_cell,_top_of_crypt_(Distal)\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL5A1 KCNT2 CHRNA4 SSUH2	1.46e-04	148	80	4	dfd3f2c4b884ea9e23831a242a89ac985b409640
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	KCNT2 TENM3 SYT2 CRB2	1.50e-04	149	80	4	cc6224c6b79f43b97adc1ce48ca4906bff2ad318
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	KCNT2 TENM3 SYT2 CRB2	1.50e-04	149	80	4	24a7538b54b2a5291503c7493fefed4e45e8d710
ToppCell	NS-moderate-d_07-13-Epithelial-FOXN4+\|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	DNAH3 DZIP1L PCSK4 CFAP46	1.84e-04	157	80	4	410c9d74a2085179cfb39853cb6d330fa98c9c1b
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	KCNT2 TENM3 LAMA5 CRB2	1.88e-04	158	80	4	e7db0ee4740e3c7a4d97d7cd7462e2c2ab458a4b
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	KCNT2 TENM3 LAMA5 CRB2	1.88e-04	158	80	4	d39e020c3e77eb9d3de600a171d22f94357061d4
ToppCell	facs-Marrow-T-cells-24m-Lymphocytic-pre_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL5A1 KL NRXN3 SYT2	1.88e-04	158	80	4	f296ca24fdedc33f1d24b79e7660763114ce7fa3
ToppCell	facs-Marrow-T-cells-24m-Lymphocytic-precursor_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL5A1 KL NRXN3 SYT2	1.88e-04	158	80	4	8c7108f2c40d97a317762ba0b8eca76542b2ebaf
ToppCell	COVID-19-kidney-Technical/muscle_(Mes)\|kidney / Disease (COVID-19 only), tissue and cell type	DNAH3 EYS NRXN3 SYT1	1.93e-04	159	80	4	5335cbcdeaf2bbd0268bbfe0e45c8c0d288e640d
ToppCell	Mild-Myeloid-Mast\|Mild / Condition, Lineage, Cell class and cell subclass	PITPNM2 EYS TANC1 HDC	2.22e-04	165	80	4	5fa9552c37890c5cc7e672a47038aebba2413cb4
ToppCell	Mild-Myeloid-Mast-\|Mild / Condition, Lineage, Cell class and cell subclass	PITPNM2 EYS TANC1 HDC	2.22e-04	165	80	4	93d3909a0f5f43d473d5005c842d7d73e25eceed
ToppCell	TCGA-Ovary-Primary_Tumor-Ovarian_Carcinoma-Serous_Cystadenocarcinoma-5\|TCGA-Ovary / Sample_Type by Project: Shred V9	ZXDC STK36 NR2C2 RNF123	2.27e-04	166	80	4	32d2eaf8a5d03881bf74d680825af2d5110b082d
ToppCell	Adult-Mesenchymal-myofibroblast_cell\|Adult / Lineage, Cell type, age group and donor	COL5A1 SERPINE3 KCNT2 BHMT2	2.32e-04	167	80	4	d584a8548a5317bd9686b3be8246ae6ed568796b
ToppCell	3'-GW_trimst-1-SmallIntestine-Epithelial-neuro-epithelial-L_cells_(PYY+)\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	VWA5B2 EYS CYP4F2 CYP4F3	2.38e-04	168	80	4	0f736d58cb0ff042fa3ce58e36bde37b6976f8fc
ToppCell	390C-Epithelial_cells-Epithelial-I_(AT1)\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	BCLAF3 ANKRD44 LAMA5 TANC1	2.43e-04	169	80	4	665b958f4a720ca369a8a0abc7fbe8b6e13c8ce5
ToppCell	390C-Epithelial_cells-Epithelial-I_(AT1)-\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	BCLAF3 ANKRD44 LAMA5 TANC1	2.43e-04	169	80	4	6614c9851537e4c21b1e45ff0cc3bad07ef9d034
ToppCell	3'_v3-bone_marrow-Mast-Mast_cell_lympho\|bone_marrow / Manually curated celltypes from each tissue	COL5A1 LRRC27 PCSK4 HDC	2.49e-04	170	80	4	4dedf482cd4521b3f87d2b5ae80f7a3ea8686a15
ToppCell	5'-GW_trimst-1.5-SmallIntestine-Epithelial-neuro-epithelial-I_cells_(CCK+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	VWA5B2 EYS HTR1E OTOG	2.60e-04	172	80	4	2651dece87c3e3d2d6370f5274ebae357474b825
ToppCell	Globus_pallidus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	VWA5B2 ATG9B SYT2 CFAP46	2.66e-04	173	80	4	7e3897868dd3f6e4974f593c60649a543ffc8693
ToppCell	10x5'-Liver-Lymphocytic_T_CD8-Tnaive/CM_CD8\|Liver / Manually curated celltypes from each tissue	ATG9B EYS KL CYP4F12	2.72e-04	174	80	4	03918ca51ae3b4c9c1a74769b08ea23f518286ba
ToppCell	5'-GW_trimst-1.5-SmallIntestine-Epithelial-neuro-epithelial-K_cells_(GIP+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	VWA5B2 KL CYP4F3 CYP4F12	2.72e-04	174	80	4	3503c7dec498597f76a86dbd5e4bb2311e743bde
ToppCell	facs-Heart-LV-24m-Mesenchymal-valve_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C3orf62 DZIP1L NR1H3 PRSS45P	2.72e-04	174	80	4	a0a059bb2a64d7011e206db2ebcdf3eb655a925a
ToppCell	Basal_cells-Cryobiopsy_01\|World / lung cells shred on cell class, cell subclass, sample id	COL5A1 FMO2 CYP4F12 KLHL17	2.72e-04	174	80	4	a0060be3940043015dcc49a5157de5541aed24a1
ToppCell	facs-Heart-LV-24m-Mesenchymal-valve_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C3orf62 DZIP1L NR1H3 PRSS45P	2.72e-04	174	80	4	7cd6f9103133f8d7b90f9ff4b3b0b078cf554542
ToppCell	PND03-Epithelial-Epithelial_Airway-Neurosecretory-PNEC-PNEC_mature\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	KL SYT1 SYT2 PCSK4	2.78e-04	175	80	4	8362a46f5804333baa84cd56d450bc147f372a7e
ToppCell	PND03-Epithelial-Epithelial_Airway-Neurosecretory-PNEC\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	KL SYT1 SYT2 PCSK4	2.78e-04	175	80	4	8b4c62e608f0ec84e563bbf0ebffe3ed44085298
ToppCell	CV-Severe-7\|CV / Virus stimulation, Condition and Cluster	ANKRD44 SMG1 CDH20 SLC43A3	2.84e-04	176	80	4	3de0c7d77210049e5616db21eed1490a17a5ec2d
ToppCell	COVID-19-kidney-PCT-S3-2\|COVID-19 / Disease (COVID-19 only), tissue and cell type	KCNT2 BHMT2 CYP4F3 CHRNA4	2.84e-04	176	80	4	b6497324e3e52f514ce556a3fa0c3011c45dcc7b
ToppCell	facs-Brain_Non-Myeloid-Striatum-24m-Neuronal-neuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NRXN3 HIPK4 TRPM2 SYT1	2.96e-04	178	80	4	a74e5a390cbeaca9de1fdb7b2a0e50783bd202dd
ToppCell	facs-Brain_Non-Myeloid-Striatum-24m-Neuronal-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NRXN3 HIPK4 TRPM2 SYT1	2.96e-04	178	80	4	1bddbc083c36657bd6910f7466126ab325e88176
ToppCell	facs-Brain_Non-Myeloid-Striatum-24m-Neuronal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NRXN3 HIPK4 TRPM2 SYT1	3.03e-04	179	80	4	a3922476f33d2e4137a12dbda21a1703dff79684
ToppCell	390C-Fibroblasts-Fibroblast-G\|390C / Donor, Lineage, Cell class and subclass (all cells)	COL5A1 FMO2 TENM3 BHMT2	3.09e-04	180	80	4	137fc14859c89e1ecd98bee388bb58c04b835847
ToppCell	PCW_05-06-Endothelial-Endothelial_mature-endo_arterial_(9)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	EYS KL ITLN1 SSUH2	3.09e-04	180	80	4	5861b44acfb8fe92c281c8355bf19c059b3dcd64
ToppCell	390C-Fibroblasts-Fibroblast-G-\|390C / Donor, Lineage, Cell class and subclass (all cells)	COL5A1 FMO2 TENM3 BHMT2	3.09e-04	180	80	4	cd6790de050151fedfa2c5ea6ad58b72665414b2
ToppCell	droplet-Liver-nan-3m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SYT12 TANC1 SLC43A3 HDC	3.16e-04	181	80	4	a53f05c4c47465ee62e353716456bd09ab464b23
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	KCNT2 TENM3 SYT2 CRB2	3.16e-04	181	80	4	5f2d3a08577c440c944778d07aa993c6e7873f3d
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	KCNT2 TENM3 SYT2 CRB2	3.16e-04	181	80	4	c7c5f7d4c397b4613c772413a0a679377efffff3
ToppCell	COPD-Epithelial-ATI\|World / Disease state, Lineage and Cell class	FMO2 KCNT2 LAMA5 SYT1	3.22e-04	182	80	4	e95d946a43b1579af199900bb0e3eacbb9d65300
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_1-D122\|Adult / Lineage, Cell type, age group and donor	FMO2 KCNT2 LAMA5 SYT1	3.36e-04	184	80	4	561592edc3083fad41b91811151b442207c65dd9
ToppCell	Fetal_29-31_weeks-Mesenchymal-pericyte_cell-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	NRXN3 CDH20 KCNT2 TANC1	3.43e-04	185	80	4	a7dba7db79275884b2a93d8a16f2e0c739e71370
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	KCNT2 TENM3 SYT2 CRB2	3.43e-04	185	80	4	34fcfd635c828dad9643bbf1c908d79282d6f5d9
ToppCell	droplet-Liver-LIVER_HEP-30m-Endothelial-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PITPNM2 COL5A1 LAMA5 TANC1	3.43e-04	185	80	4	bdd2e6cb20294b39a9d856004bf57ba69cf877e2
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Neuronal-neurons_B-Branch_B3_(IPAN)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	VWA5B2 CCNP SYT1 CHRNA4	3.43e-04	185	80	4	edb114487206e4e8df4c7878285df40f49b7fd64
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	KCNT2 TENM3 SYT2 CRB2	3.43e-04	185	80	4	8816f2909ed11833ff3d0ed96b9cb6d6fe9e1578
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Neuronal-interneuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NRXN3 SYT12 SYT1 SYT2	3.50e-04	186	80	4	d1d01ce46e62944aa9864eda47e8401b5f0d2bdc
ToppCell	wk_15-18-Mesenchymal-Mesothelial-Early_mesothelial\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	SERPINE3 NRXN3 ITLN1 CRB2	3.50e-04	186	80	4	ae4b6ecfc1850c0a01a11b9dd9718880f2a24fe0
ToppCell	facs-Brain_Non-Myeloid-Striatum_-18m-Neuronal-interneuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NRXN3 SYT1 SYT2 SSUH2	3.50e-04	186	80	4	a1ab273b01971d6a892912560d387685dd657179
ToppCell	COPD-Epithelial-ATI\|COPD / Disease state, Lineage and Cell class	FMO2 KCNT2 LAMA5 SYT1	3.50e-04	186	80	4	df0977f6f48a2d4e11b59971f098b01204242f0f
ToppCell	facs-Brain_Non-Myeloid-Striatum_-18m-Neuronal-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NRXN3 SYT1 SYT2 SSUH2	3.57e-04	187	80	4	ef3c85c01bc3da408ae288b6e3096ad888a12e63
ToppCell	facs-Brain_Non-Myeloid-Cerebellum_-18m-Neuronal-interneuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NRXN3 SYT1 SYT2 MBOAT4	3.57e-04	187	80	4	1b2fdbfb1ce3f19795dfc4b1da5a94f4b057ec41
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	KCNT2 TENM3 SYT2 CRB2	3.64e-04	188	80	4	b21e93a70583c30d05c0833cd3d4d4bca44a039e
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	KCNT2 TENM3 SYT2 CRB2	3.64e-04	188	80	4	874404a4fd9aa42873f6c53dc42da22d3b0fdb9e
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	COL5A1 KCNT2 TENM3 TANC1	3.72e-04	189	80	4	71397e993a77d70b2eeede240bdfc7660b558987
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	COL5A1 KCNT2 TENM3 TANC1	3.72e-04	189	80	4	4eea4759520c312bd17a681034d8074e47093d2b
ToppCell	facs-Brain_Non-Myeloid-Striatum_-18m-Neuronal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NRXN3 SYT1 SYT2 SSUH2	3.72e-04	189	80	4	3d838da870623a6a278ddc8e6cedca85d9877e50
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	COL5A1 KCNT2 TENM3 SYT1	3.87e-04	191	80	4	a58c75e9580139fb370b498d95660f10f3a2a27b
ToppCell	PCW_05-06-Mesenchymal-Mesenchymal_fibroblastic-mes_mesothelial_(19)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	NRXN3 ITLN1 LAMA5 CRB2	3.87e-04	191	80	4	4c4eb61e6179d2f8fc524d2f813db9cba84f67a2
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	COL5A1 KCNT2 TENM3 TANC1	3.87e-04	191	80	4	39092a0aff8097617820c59f5fea9ee2bb4f63a2
ToppCell	wk_20-22-Hematologic-Myeloid-APOE+_Mac1\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	ABHD4 NR1H3 SLC43A3 KLHDC8B	3.87e-04	191	80	4	c204ec71b7755b46a18d3a6aa84d0f407145ce9d
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	COL5A1 KCNT2 TENM3 TANC1	3.87e-04	191	80	4	ee5f1b1c59029c46cbb1a00935c03b9317bb9da9
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	COL5A1 KCNT2 TENM3 SYT1	4.02e-04	193	80	4	f1199518c3626fd29bfce65070dd21a660671213
ToppCell	LV-01._Fibroblast_I\|LV / Chamber and Cluster_Paper	ANKRD44 COL5A1 FMO2 KCNT2	4.02e-04	193	80	4	dc17f3b9758936d428cf17f77a1ce6d4c479b165
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L3-5_SST_MAFB\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ANKRD44 EYS TENM3 TANC1	4.02e-04	193	80	4	e74fdc8718fe0933e1f4dd3fe37e2134983b99b6
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L3-5_SST_MAFB\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ANKRD44 EYS TENM3 TANC1	4.02e-04	193	80	4	658c2b30a4d806c5ce78ea4392fe8eb86b8d1e99
ToppCell	PND07-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_mature\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	COL5A1 FMO2 KCNT2 TENM3	4.02e-04	193	80	4	051f61156b0e2e95292b2d8377faf3190b50f264
ToppCell	RV-02._Fibroblast_II\|RV / Chamber and Cluster_Paper	ANKRD44 COL5A1 FMO2 KCNT2	4.10e-04	194	80	4	11c79a8c56ece42713b04b321982e41e239f07a5
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L3-5_SST_MAFB\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ANKRD44 EYS TENM3 TANC1	4.10e-04	194	80	4	83863da11dfbe59b2d0a2c08db40b537c150588c
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_3\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ANKRD44 EYS TENM3 TANC1	4.10e-04	194	80	4	e5990880961d2469759ce4b3b20ae93ace3ebd1f
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L3-5_SST_MAFB\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ANKRD44 EYS TENM3 TANC1	4.10e-04	194	80	4	1bcb3fafd498614f7bac2b1c9b7de56e39110f65
ToppCell	5'-Parenchyma_lung-Mesenchymal-Fibro-meso-mesothelial_cell-Mesothelium-Mesothelium_L.2.6.0.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	HTR1E KCNT2 ITLN1 CRB2	4.10e-04	194	80	4	421344cc4b601d9745fa72d0af3124dab11d1d27
Drug	Betamethasone-d5	PIK3R4 UGT1A4 COL5A1 NR2C2 KL LAMA5 SYT1 CASP9 CYP4F2 CYP4F3 CYP4F12 PLEC PJA1 MAPK7 CYP4F11 CHRNA4 HDC	3.26e-06	1340	80	17	CID000003003
Drug	AC1Q7AUJ	UGT1A4 CYP4F2 CYP4F3 CYP4F12 PLEC CYP4F11	3.57e-06	117	80	6	CID000003303
Drug	diosmetin	UGT1A4 CYP4F2 CYP4F3 CYP4F12 CYP4F11	1.24e-05	85	80	5	CID005281612
Drug	dichloran	CYP4F2 CYP4F3 CYP4F12 CYP4F11	1.30e-05	41	80	4	CID000007430
Drug	3 -hydroxypregn-5-en-20-one	UGT1A4 NR1H3 CYP4F2 CYP4F3 CYP4F12 PLEC CYP4F11	2.07e-05	238	80	7	CID000001027
Disease	congenital myasthenic syndrome (implicated_via_orthology)	SYT1 SYT2 CHRNA4	9.71e-06	16	78	3	DOID:3635 (implicated_via_orthology)
Disease	congenital myasthenic syndrome 7 (implicated_via_orthology)	SYT1 SYT2	4.12e-05	4	78	2	DOID:0110659 (implicated_via_orthology)
Disease	neuromuscular junction disease (implicated_via_orthology)	SYT1 SYT2	6.86e-05	5	78	2	DOID:439 (implicated_via_orthology)
Disease	hexadecenedioate (C16:1-DC) measurement	CYP4F2 CYP4F11	2.45e-04	9	78	2	EFO_0800562
Disease	hypertension (biomarker_via_orthology)	KL CASP9 CYP4F2 CYP4F12 CYP4F11	3.45e-04	227	78	5	DOID:10763 (biomarker_via_orthology)
Disease	heart disease (biomarker_via_orthology)	CASP9 ALDH2	9.14e-04	17	78	2	DOID:114 (biomarker_via_orthology)
Disease	anorectal malformation	TRPM2 KLHL17	1.15e-03	19	78	2	MONDO_0019938
Disease	creatinine measurement	RNF123 CDH20 C3orf62 CCNP LAMA5 SYT1 CASP9 NR1H3 PLEC	1.23e-03	995	78	9	EFO_0004518
Disease	Myasthenic Syndromes, Congenital	SYT2 PLEC	1.83e-03	24	78	2	C0751882
Disease	retinitis pigmentosa (implicated_via_orthology)	EYS CRB2	2.32e-03	27	78	2	DOID:10584 (implicated_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
RTHTMPTWVRRVFLD	CHRNA4	336	P43681
WRDILSHGRFKRRMT	CHD8	1461	Q9HCK8
IFISMPPLFWRSHRR	HTR1E	151	P28566
ARMWHRLALNSPSVS	CFAP46	1181	Q8IYW2
ESFGWARRPMLERIH	ABHD4	261	Q8TB40
DLPSWSFLRSRRMRD	CCNP	291	Q9H8S5
WRESLGHTRLHRMTS	BPTF	966	Q12830
SLPSVWASLRRREMV	CCDC14	36	Q49A88
SRLLFLSMHWARSIP	NR2C2	391	P49116
RRSFSDRLRVTPWPM	NR1H3	226	Q13133
LSHLEMTWTNRRNFP	RADX	221	Q6NSI4
FQPRHDSMDWRRIST	DZIP1L	26	Q8IYY4
FMHWQIPLSRRFRSV	HDC	346	P19113
RSLLERWTRMARPAA	MAPK7	566	Q13164
SPMQHWRNSSLLRYR	ITLN1	156	Q8WWA0
RFHAWTEVPAMREAR	KLHL34	401	Q8N239
REHWRLLSPSMSPIF	EYS	1481	Q5T1H1
RMLTWESHERISPSA	HIPK4	326	Q8NE63
WHRVRLAMERPAATT	CRB2	956	Q5IJ48
IRPHWMFVLDSLLSR	MAP3K6	1096	O95382
PFLTWRDMQHLVVRA	PCSK4	391	Q6UW60
SRIAPRSFWMTLLTD	NUP85	566	Q9BW27
DSSWHFLMVSRDRLR	NRXN3	106	Q9Y4C0
DNMWLTPLHRAVASR	ANKRD44	71	Q8N8A2
DHPLLRRKSMQWARR	KCNT2	1006	Q6UVM3
ILARHRNWPSLSMHV	LAMA5	3356	O15230
RGASPSRHSISEWRM	PITPNM2	316	Q9BZ72
VLATVRSRHMPWRTY	NPBWR2	146	P48146
RARRSMDRAGAPWHL	MED18	71	Q9BUE0
AWESVAPMNIRRSTH	KLHL17	556	Q6TDP4
MARSRSRSPRWKHRS	BCLAF3	1	A2AJT9
LDMHTKPWIRARARR	BHMT2	326	Q9H2M3
IVSNSRRWALMIDPH	DNAH3	3071	Q8TD57
LMTARPLDREEFSWH	CDH20	446	Q9HBT6
RSTWMRHLLQHPTLS	B3GALNT2	71	Q8NCR0
WDALLSRELFRPHMI	CASP9	26	P55211
LMHSSILAPERESWR	C3orf62	121	Q6ZUJ4
GDKWSRHRRMLTPAF	CYP4F11	141	Q9HBI6
GDKWSRHRRMLTPAF	CYP4F12	141	Q9HCS2
MDVHTRWKARSALRP	COL5A1	1	P20908
GDKWSRHRRMLTPAF	CYP4F2	141	P78329
LSLMRFSLAHPLWRP	ATG9B	706	Q674R7
IHSFANEFIRSWPMR	MBOAT4	361	Q96T53
ALPRSLSHWEMSRAQ	MAPKBP1	821	O60336
WDSVFHTRFRSMLRN	FMO2	231	Q99518
SFSLARRRWEALPAM	KLHDC8B	301	Q8IXV7
IALSSHWINPRRMTD	KL	296	Q9UEF7
SWSFFRSDELRRHMR	KLF17	321	Q5JT82
SHVPMWSVRLLTRAD	CRIPAK	211	Q8N1N5
GEKWSRHRRMLTPAF	CYP4F3	141	Q08477
MLLLTRSPTAWHRLS	SCO2	1	O43819
SVAMSSWERRLHRAK	OTOG	91	Q6ZRI0
AELRHWSDMLANPRR	SYT1	386	P21579
RHWSDMLANPRRPIA	SYT2	386	Q8N9I0
HRPRSWREMPIRFAD	TARS3	501	A2RTX5
ATLRRPVSMWHAVRR	SYT12	406	Q8IV01
LFRSLRPRWHDTAMT	LMBR1L	376	Q6UX01
RFLRMWAVEHSLPRN	LRRC27	166	Q9C0I9
RTWSVERRRHPMDSY	SLC26A8	946	Q96RN1
LSLDVSRRDWPLHVM	SMG1	2266	Q96Q15
RDKTRMFCHPSFREW	TANC1	806	Q9C0D5
CSTWHVARTFLLMPR	SLC43A3	196	Q8NBI5
MARRPRNSRAWHFVL	SPSB3	1	Q6PJ21
LWHRFSMVLRLPEEA	STK36	881	Q9NRP7
RSWPSFLEHRVPAMT	SSUH2	61	Q9Y2M2
SPWRRMDASHRGRLL	ALDH2	91	P05091
RIRRLSMHPLYQSWV	PIK3R4	1186	Q99570
FSRALWVPVRDIIMH	PRSS45P	56	Q7RTY3
IWPSLFHMLRRTHTE	ZNF441	206	Q8N8Z8
GWTFTSMSKLLRHRR	ZXDC	366	Q2QGD7
FLDWTRPTSEMLLRR	RNF123	1096	Q5XPI4
HTLYPMVTRWRRNED	TRPM2	1346	O94759
TIHLWTTSLRRARMD	SERPINE3	281	A8MV23
WDRLSAITMPSVARH	TENM3	1886	Q9P273
WMRHHTAAFEERRFP	PLEC	431	Q15149
FFWPSLLRMHERTHT	ZNF563	206	Q8TA94
AATTHRTLELMRWHR	VWA5B2	456	Q8N398
WLRRPRIDSHRRTMA	TMEM207	76	Q6UWW9
RRRTMADPDFWTHSD	PJA1	341	Q8NG27
WPSLLRMHERTHTGE	ZNF44	256	P15621
WLSMREALRELHARG	UGT1A4	41	P22310