Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	small GTPase binding	MICAL1 SIKE1 RABGAP1 TRIP11 GGA3 EVI5 AP1G1 ROCK1 EVI5L RAB11FIP3	6.29e-05	321	134	10	GO:0031267
GeneOntologyMolecularFunction	GTPase binding	MICAL1 SIKE1 RABGAP1 TRIP11 GGA3 EVI5 AP1G1 ROCK1 EVI5L RAB11FIP3	1.61e-04	360	134	10	GO:0051020
GeneOntologyMolecularFunction	kinase activity	GAK NEK7 DGKD IP6K1 PFKFB2 PFKFB3 ACVR1B TRRAP MET KSR1 LIMK1 NRK ROCK1 MAP3K13 ATM	1.92e-04	764	134	15	GO:0016301
GeneOntologyMolecularFunction	6-phosphofructo-2-kinase activity	PFKFB2 PFKFB3	2.66e-04	4	134	2	GO:0003873
GeneOntologyMolecularFunction	phosphotransferase activity, alcohol group as acceptor	GAK NEK7 DGKD IP6K1 PFKFB2 PFKFB3 ACVR1B MET KSR1 LIMK1 NRK ROCK1 MAP3K13 ATM	2.99e-04	709	134	14	GO:0016773
GeneOntologyMolecularFunction	cytoskeletal protein binding	VAPA MICAL1 KIF23 PACSIN1 NCKIPSD RABGAP1 RAB3C DST AP1G1 MYH14 FRG1 TLN1 SYNE2 CEP70 ROCK1 TLN2 JAKMIP1 UTRN	4.02e-04	1099	134	18	GO:0008092
GeneOntologyMolecularFunction	testosterone 6-beta-hydroxylase activity	CYP3A7 CYP3A4	4.41e-04	5	134	2	GO:0050649
GeneOntologyMolecularFunction	pheromone binding	OBP2B OBP2A	4.41e-04	5	134	2	GO:0005550
GeneOntologyMolecularFunction	fructose-2,6-bisphosphate 2-phosphatase activity	PFKFB2 PFKFB3	4.41e-04	5	134	2	GO:0004331
GeneOntologyMolecularFunction	phosphofructokinase activity	PFKFB2 PFKFB3	9.18e-04	7	134	2	GO:0008443
GeneOntologyBiologicalProcess	regulation of plasma membrane bounded cell projection organization	GAK LZTS3 PACSIN1 NCKIPSD ATP8B1 RABGAP1 EVI5 MET NLGN3 LIMK1 SYNE2 VPS35 RTCA MAP3K13 RAB21 PLXNB1 EVI5L RAB11FIP3	6.13e-06	846	130	18	GO:0120035
GeneOntologyBiologicalProcess	regulation of cell projection organization	GAK LZTS3 PACSIN1 NCKIPSD ATP8B1 RABGAP1 EVI5 MET NLGN3 LIMK1 SYNE2 VPS35 RTCA MAP3K13 RAB21 PLXNB1 EVI5L RAB11FIP3	8.04e-06	863	130	18	GO:0031344
Domain	DUF1220	NBPF11 NBPF1 NBPF15 NBPF9	3.01e-07	9	133	4	SM01148
Domain	DUF1220	NBPF11 NBPF1 NBPF15 NBPF9	7.80e-07	11	133	4	PF06758
Domain	NBPF_dom	NBPF11 NBPF1 NBPF15 NBPF9	7.80e-07	11	133	4	IPR010630
Domain	NBPF	NBPF11 NBPF1 NBPF15 NBPF9	7.80e-07	11	133	4	PS51316
Domain	-	TLN1 TLN2	5.03e-05	2	133	2	1.20.1420.10
Domain	VBS	TLN1 TLN2	5.03e-05	2	133	2	PF08913
Domain	Vinculin-bd_dom	TLN1 TLN2	5.03e-05	2	133	2	IPR015009
Domain	Talin_cent	TLN1 TLN2	5.03e-05	2	133	2	IPR015224
Domain	Talin_middle	TLN1 TLN2	5.03e-05	2	133	2	PF09141
Domain	SIKE	SIKE1 FGFR1OP2	5.03e-05	2	133	2	IPR008555
Domain	DUF837	SIKE1 FGFR1OP2	5.03e-05	2	133	2	PF05769
Domain	Coatomer/clathrin_app_Ig-like	COPG1 GGA3 AP1G1	7.41e-05	12	133	3	IPR013041
Domain	CH	MICAL1 DST SYNE2 UTRN VAV1	9.96e-05	65	133	5	SM00033
Domain	CH	MICAL1 DST SYNE2 UTRN VAV1	1.42e-04	70	133	5	PF00307
Domain	Talin-1	TLN1 TLN2	1.50e-04	3	133	2	IPR015710
Domain	von_Ebner_gland	OBP2B OBP2A	1.50e-04	3	133	2	IPR002450
Domain	-	MICAL1 DST SYNE2 UTRN VAV1	1.52e-04	71	133	5	1.10.418.10
Domain	CH	MICAL1 DST SYNE2 UTRN VAV1	1.73e-04	73	133	5	PS50021
Domain	CH-domain	MICAL1 DST SYNE2 UTRN VAV1	1.97e-04	75	133	5	IPR001715
Domain	ILWEQ_dom	TLN1 TLN2	2.99e-04	4	133	2	IPR002558
Domain	ILWEQ	TLN1 TLN2	2.99e-04	4	133	2	SM00307
Domain	FERM_f0	TLN1 TLN2	2.99e-04	4	133	2	PF16511
Domain	6Phosfructo_kin	PFKFB2 PFKFB3	2.99e-04	4	133	2	IPR013079
Domain	ILWEQ	TLN1 TLN2	2.99e-04	4	133	2	PD011820
Domain	-	TLN1 TLN2	2.99e-04	4	133	2	1.20.1410.10
Domain	I_LWEQ	TLN1 TLN2	2.99e-04	4	133	2	PF01608
Domain	I_LWEQ	TLN1 TLN2	2.99e-04	4	133	2	PS50945
Domain	FERM_f0	TLN1 TLN2	2.99e-04	4	133	2	IPR032425
Domain	6Pfruct_kin	PFKFB2 PFKFB3	2.99e-04	4	133	2	IPR003094
Domain	6PF2K	PFKFB2 PFKFB3	2.99e-04	4	133	2	PF01591
Domain	GAE	GGA3 AP1G1	4.96e-04	5	133	2	PS50180
Domain	Cyt_P450_E_grp-II	CYP3A7 CYP3A4	4.96e-04	5	133	2	IPR002402
Domain	Kinase-like_dom	GAK NEK7 ACVR1B TRRAP MET KSR1 LIMK1 DST NRK ROCK1 MAP3K13 ATM	5.01e-04	542	133	12	IPR011009
Domain	Spectrin	DST SYNE2 UTRN	5.63e-04	23	133	3	PF00435
Domain	ACTININ_2	DST SYNE2 UTRN	5.63e-04	23	133	3	PS00020
Domain	ACTININ_1	DST SYNE2 UTRN	5.63e-04	23	133	3	PS00019
Domain	Actinin_actin-bd_CS	DST SYNE2 UTRN	5.63e-04	23	133	3	IPR001589
Domain	Cyt_P450_E_CYP3A	CYP3A7 CYP3A4	7.41e-04	6	133	2	IPR008072
Domain	-	GGA3 AP1G1	7.41e-04	6	133	2	2.60.40.1230
Domain	Clathrin_g-adaptin_app	GGA3 AP1G1	7.41e-04	6	133	2	IPR008153
Domain	FAT	TRRAP ATM	7.41e-04	6	133	2	PS51189
Domain	FATC	TRRAP ATM	7.41e-04	6	133	2	PS51190
Domain	FAT	TRRAP ATM	7.41e-04	6	133	2	PF02259
Domain	PIK-rel_kinase_FAT	TRRAP ATM	7.41e-04	6	133	2	IPR003151
Domain	FATC_dom	TRRAP ATM	7.41e-04	6	133	2	IPR003152
Domain	PIK_FAT	TRRAP ATM	7.41e-04	6	133	2	IPR014009
Domain	FATC	TRRAP ATM	7.41e-04	6	133	2	SM01343
Domain	Vinculin/catenin	TLN1 TLN2	1.03e-03	7	133	2	IPR006077
Domain	ZF_DAG_PE_1	DGKD KSR1 ROCK1 VAV1	1.12e-03	64	133	4	PS00479
Domain	ZF_DAG_PE_2	DGKD KSR1 ROCK1 VAV1	1.12e-03	64	133	4	PS50081
Domain	Spectrin_repeat	DST SYNE2 UTRN	1.13e-03	29	133	3	IPR002017
Domain	C1	DGKD KSR1 ROCK1 VAV1	1.19e-03	65	133	4	SM00109
Domain	PE/DAG-bd	DGKD KSR1 ROCK1 VAV1	1.26e-03	66	133	4	IPR002219
Domain	SPEC	DST SYNE2 UTRN	1.51e-03	32	133	3	SM00150
Domain	Spectrin/alpha-actinin	DST SYNE2 UTRN	1.51e-03	32	133	3	IPR018159
Domain	Alpha_adaptinC2	GGA3 AP1G1	1.75e-03	9	133	2	PF02883
Domain	PG/BPGM_mutase_AS	PFKFB2 PFKFB3	1.75e-03	9	133	2	IPR001345
Domain	Clathrin_a/b/g-adaptin_app_Ig	GGA3 AP1G1	1.75e-03	9	133	2	IPR008152
Domain	Alpha_adaptinC2	GGA3 AP1G1	1.75e-03	9	133	2	SM00809
Domain	Lipocln_cytosolic_FA-bd_dom	OBP2B OBP2A FABP4	1.80e-03	34	133	3	IPR000566
Domain	Lipocalin	OBP2B OBP2A FABP4	1.80e-03	34	133	3	PF00061
Domain	-	OBP2B OBP2A FABP4	1.96e-03	35	133	3	2.40.128.20
Domain	PGAM	PFKFB2 PFKFB3	2.18e-03	10	133	2	SM00855
Domain	PG_MUTASE	PFKFB2 PFKFB3	2.18e-03	10	133	2	PS00175
Domain	Calycin-like	OBP2B OBP2A FABP4	2.30e-03	37	133	3	IPR011038
Domain	Calycin	OBP2B OBP2A FABP4	2.30e-03	37	133	3	IPR012674
Domain	Ser-Thr/Tyr_kinase_cat_dom	NEK7 MET KSR1 LIMK1 MAP3K13	3.09e-03	138	133	5	IPR001245
Domain	His_Pase_superF_clade-1	PFKFB2 PFKFB3	3.17e-03	12	133	2	IPR013078
Domain	His_Phos_1	PFKFB2 PFKFB3	3.17e-03	12	133	2	PF00300
Domain	Ser/Thr_kinase_AS	GAK NEK7 ACVR1B KSR1 LIMK1 NRK ROCK1 MAP3K13	4.08e-03	357	133	8	IPR008271
Domain	P_typ_ATPase_c	ATP8B4 ATP8B1	4.33e-03	14	133	2	IPR032630
Domain	P-type_ATPase_N	ATP8B4 ATP8B1	4.33e-03	14	133	2	IPR032631
Domain	P-type_ATPase_IV	ATP8B4 ATP8B1	4.33e-03	14	133	2	IPR006539
Domain	IRS	TLN1 TLN2	4.33e-03	14	133	2	PF02174
Domain	IRS_PTB	TLN1 TLN2	4.33e-03	14	133	2	IPR002404
Domain	PhoLip_ATPase_C	ATP8B4 ATP8B1	4.33e-03	14	133	2	PF16212
Domain	PhoLip_ATPase_N	ATP8B4 ATP8B1	4.33e-03	14	133	2	PF16209
Domain	PROTEIN_KINASE_ST	GAK NEK7 ACVR1B KSR1 LIMK1 NRK ROCK1 MAP3K13	4.43e-03	362	133	8	PS00108
Domain	Clathrin/coatomer_adapt-like_N	COPG1 AP1G1	4.97e-03	15	133	2	IPR002553
Domain	Adaptin_N	COPG1 AP1G1	4.97e-03	15	133	2	PF01602
Domain	TBC	RABGAP1 EVI5 EVI5L	5.12e-03	49	133	3	SM00164
Domain	-	TRRAP ATM	5.66e-03	16	133	2	1.10.1070.11
Domain	PI3Kc	TRRAP ATM	5.66e-03	16	133	2	SM00146
Domain	RabGAP-TBC	RABGAP1 EVI5 EVI5L	6.38e-03	53	133	3	PF00566
Domain	LIPOCALIN	OBP2B OBP2A	6.38e-03	17	133	2	PS00213
Domain	Rab-GTPase-TBC_dom	RABGAP1 EVI5 EVI5L	7.07e-03	55	133	3	IPR000195
Domain	TBC_RABGAP	RABGAP1 EVI5 EVI5L	7.07e-03	55	133	3	PS50086
Pathway	REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING	MET LIMK1 MYH14 ROCK1 PLXNB1	7.19e-07	24	103	5	M2243
Pathway	REACTOME_SEMAPHORIN_INTERACTIONS	MET LIMK1 MYH14 TLN1 ROCK1 PLXNB1	6.99e-06	64	103	6	M7923
Pathway	REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE	LIMK1 MYH14 ROCK1 PLXNB1	1.19e-05	20	103	4	M18415
Pathway	REACTOME_SEMAPHORIN_INTERACTIONS	MET LIMK1 TLN1 ROCK1 PLXNB1	3.40e-05	51	103	5	MM14967
Pathway	REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING	MET ROCK1 PLXNB1	1.62e-04	15	103	3	MM15037
Pubmed	A novel gene family NBPF: intricate structure generated by gene duplications during primate evolution.	NBPF12 NBPF11 NBPF1 NBPF19 NBPF15 NBPF9 NBPF10	1.90e-12	21	143	7	16079250
Pubmed	New interaction partners for Nek4.1 and Nek4.2 isoforms: from the DNA damage response to RNA splicing.	NBPF12 DGKD PFKFB2 PFKFB3 HNRNPUL1 NBPF11 NBPF1 NBPF15 IGF2BP1 DST NBPF9 SETBP1 NBPF10 HERC2 HSPA6	3.77e-09	513	143	15	25798074
Pubmed	A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.	VAPA GPD2 CUL2 GAK KIF23 COPG1 MCM2 UFL1 COPS3 PFKFB3 HNRNPUL1 ITPR3 EVI5 EEF1G IGF2BP1 DST PRRC2C TLN1 SYNE2 VPS35 ATM HSPA6 CNOT3 EVI5L	5.24e-09	1440	143	24	30833792
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	KIF23 COPG1 NEK7 MCM2 DGKD SMARCAD1 COPS3 HNRNPUL1 MCM10 TRRAP LUZP1 EEF1G METTL13 DST AP1G1 MYH14 TLN1 VPS35 RTCA CCT6B HERC2 UTRN HSPA6	7.90e-09	1353	143	23	29467282
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	GPD2 MICAL1 GAK LZTS3 PACSIN1 DOCK8 NCKIPSD COPS3 IDH3A TRIP11 LUZP1 NLGN3 EEF1G DST AP1G1 MYH14 PRRC2C TLN1 VPS35 FGA TLN2 UTRN DNAH11	2.22e-08	1431	143	23	37142655
Pubmed	Evolutionary history and genome organization of DUF1220 protein domains.	NBPF12 NBPF1 NBPF15 NBPF9	5.64e-08	10	143	4	22973535
Pubmed	Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.	VAPA CUL2 GAK KIF23 COPG1 MCM2 UFL1 SMARCAD1 HNRNPUL1 TRRAP LUZP1 MET EEF1G METTL13 DST PRRC2C SYNE2 CDYL RAB21 HSPA6 CNOT3	8.63e-08	1297	143	21	33545068
Pubmed	Comparative proximity biotinylation implicates the small GTPase RAB18 in sterol mobilization and biosynthesis.	VAPA GAK COPG1 UFL1 RABGAP1 TRIP11 LUZP1 ITPR3 DST ODR4 PRRC2C TLN1 SYNE2 PDCL	1.06e-07	568	143	14	37774976
Pubmed	Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity.	VAPA GAK ERCC5 LEO1 NEK7 ACVR1B TRRAP LUZP1 MET KSR1 LIMK1 DST NRK TLN1 MAP3K13 UTRN PCDH18	2.28e-07	910	143	17	36736316
Pubmed	SENP3 regulates the global protein turnover and the Sp1 level via antagonizing SUMO2/3-targeted ubiquitination and degradation.	COPG1 UFL1 HNRNPUL1 TRRAP AP1G1 VPS35	2.68e-07	64	143	6	26511642
Pubmed	Network organization of the huntingtin proteomic interactome in mammalian brain.	VAPA GPD2 CUL2 DOCK8 NCKIPSD TRRAP RAB3C EEF1G DST AP1G1 SETBP1 VPS35 CCT6B ROCK1	3.11e-07	621	143	14	22794259
Pubmed	N-Terminomics for the Identification of In Vitro Substrates and Cleavage Site Specificity of the SARS-CoV-2 Main Protease.	GAK TRIP11 LUZP1 ITPR3 MET EEF1G DST PRRC2C TLN1 UTRN CAVIN2	3.21e-07	360	143	11	33111431
Pubmed	Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.	SIKE1 FGFR1OP2 MTMR12 DOCK8 IFFO1 NCKIPSD CCDC85C PFKFB2 LUZP1 KSR1 DST UTRN	3.57e-07	446	143	12	24255178
Pubmed	Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.	VAPA GPD2 ERCC5 LEO1 COPG1 MAT2B MCM2 UFL1 SMARCAD1 HNRNPUL1 NOSIP EEF1G IGF2BP1 AP1G1 PRRC2C FRG1 TLN1 SYNE2 VPS35 HSPA6 SPINK5	3.63e-07	1415	143	21	28515276
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	VAPA GPD2 KIF23 ATP8B4 COPG1 MAT2B MCM2 UFL1 SMARCAD1 COPS3 IDH3A HNRNPUL1 EEF1G IGF2BP1 METTL13 AP1G1 MYH14 TLN1 VPS35 TLN2 ATM	4.07e-07	1425	143	21	30948266
Pubmed	SNX27-driven membrane localisation of OTULIN antagonises linear ubiquitination and NF-κB signalling activation.	GPD2 MTMR12 ERCC5 PFKFB2 PFKFB3 EVI5 ODR4 VPS35 ROCK1 HSPA6 CNOT3	5.19e-07	378	143	11	34315543
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	MTMR12 KIF23 NCKIPSD CCDC85C PFKFB2 HNRNPUL1 TRIP11 LUZP1 KSR1 LIMK1 DST PRRC2C SYNE2 PDCL RAB21 UTRN	5.68e-07	861	143	16	36931259
Pubmed	Defining the human deubiquitinating enzyme interaction landscape.	VAPA CUL2 FGFR1OP2 COPG1 MCM2 COPS3 IDH3A TRRAP FABP4 UCHL3 FRG1 VPS35 RTCA CHMP3 HERC2 SCLT1 UTRN	9.00e-07	1005	143	17	19615732
Pubmed	Scanning the human proteome for calmodulin-binding proteins.	CDC37L1 ARMC1 DST SYNE2 HERC2 SCLT1	2.32e-06	92	143	6	15840729
Pubmed	Two-Dimensional Fractionation Method for Proteome-Wide Cross-Linking Mass Spectrometry Analysis.	VAPA LEO1 MCM2 RABGAP1 CCDC144CP IDH3A EEF1G IGF2BP1 MYH14 PRRC2C TLN1 ROCK1 TLN2 UTRN HSPA6	2.36e-06	847	143	15	35235311
Pubmed	The deubiquitinase TRABID stabilizes the K29/K48-specific E3 ubiquitin ligase HECTD1.	SIKE1 FGFR1OP2 CCDC85C TRRAP TRIP11 URGCP DST HERC2	2.93e-06	212	143	8	33853758
Pubmed	Acetylation of ELF5 suppresses breast cancer progression by promoting its degradation and targeting CCND1.	LEO1 COPG1 CMC1 MCM2 UFL1 IDH3A NOSIP EEF1G AP1G1 FRG1 TLN1 VPS35 ROCK1	3.29e-06	653	143	13	33742100
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	KIF23 COPG1 HNRNPUL1 TRRAP ITPR3 DST MYH14 PRRC2C TLN1 SYNE2 ATM HERC2 UTRN	3.29e-06	653	143	13	22586326
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	CDO1 KIF23 ERCC5 LEO1 RBBP8 MCM2 UFL1 SMARCAD1 HNRNPUL1 TRRAP URGCP TLN2 ATM CNOT3	4.10e-06	774	143	14	15302935
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	GPD2 MCM2 UFL1 IDH3A HNRNPUL1 TRRAP ITPR3 EEF1G IGF2BP1 DST MYH14 TLN1 SYNE2 HERC2 RAB21 UTRN	5.28e-06	1024	143	16	24711643
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	FGFR1OP2 LEO1 SMARCAD1 HNRNPUL1 TRIP11 LIMK1 ACAD8 DST MYH14 CEP70 CHMP3 TLN2 NR1H2 JAKMIP1 ATM HERC2 UTRN CNOT3	5.95e-06	1285	143	18	35914814
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	GAK LEO1 RBBP8 SMARCAD1 RABGAP1 TRIP11 LUZP1 NOSIP PRRC2C ROCK1 POTEJ CNOT3	6.22e-06	588	143	12	38580884
Pubmed	Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes?	NBPF12 NBPF11 NBPF1 NBPF9 SYNE2 NBPF10 FGA	7.05e-06	170	143	7	23314748
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	VAPA ERCC5 CCDC185 LEO1 RBBP8 RAB3C LUZP1 DST MYH14 PRRC2C SYNE2 VPS35 JAKMIP1 ATM POTEJ RAB21 TUBD1 HSPA6 CAVIN2	7.67e-06	1442	143	19	35575683
Pubmed	A comprehensive SARS-CoV-2-human protein-protein interactome reveals COVID-19 pathobiology and potential host therapeutic targets.	GPD2 MAT2B UFL1 PFKFB3 ITPR3 MET MYH14 ODR4 FGA JAKMIP1 CAVIN2	8.07e-06	503	143	11	36217030
Pubmed	SARS-CoV-2 uses Spike glycoprotein to control the host's anaerobic metabolism by inhibiting LDHB.	VAPA COPG1 MCM2 IDH3A HNRNPUL1 IGF2BP1 MYH14 PRRC2C TLN1 VPS35 FGA RAB21	8.55e-06	607	143	12	39147351
Pubmed	Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage.	VAPA COPG1 MAT2B MCM2 HNRNPUL1 NOSIP EEF1G DST MYH14 TLN1 CCT6B RAB21 UTRN HSPA6	1.09e-05	844	143	14	25963833
Pubmed	Proteome-wide identification of HSP70/HSC70 chaperone clients in human cells.	VAPA GPD2 CUL2 KIF23 COPG1 COPS3 RABGAP1 PFKFB3 IDH3A HNRNPUL1 NOSIP EEF1G AP1G1 TLN1 SYNE2 RTCA ROCK1 UTRN	1.37e-05	1367	143	18	32687490
Pubmed	Digging Deeper into CYP3A Testosterone Metabolism: Kinetic, Regioselectivity, and Stereoselectivity Differences between CYP3A4/5 and CYP3A7.	CYP3A7 CYP3A4	1.68e-05	2	143	2	28986474
Pubmed	Splice isoforms of ubiquitous 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase in human brain.	PFKFB2 PFKFB3	1.68e-05	2	143	2	11245921
Pubmed	Dynamics of Cytosine Methylation in the Proximal Promoters of CYP3A4 and CYP3A7 in Pediatric and Prenatal Livers.	CYP3A7 CYP3A4	1.68e-05	2	143	2	26772622
Pubmed	A novel human odorant-binding protein gene family resulting from genomic duplicons at 9q34: differential expression in the oral and genital spheres.	OBP2B OBP2A	1.68e-05	2	143	2	10607840
Pubmed	Expression of CYP3A4 and CYP3A7 in Human Foetal Tissues and its Correlation with Nuclear Receptors.	CYP3A7 CYP3A4	1.68e-05	2	143	2	25689036
Pubmed	Immunohistochemical markers of CYP3A4 and CYP3A7: a new tool towards personalized pharmacotherapy of hepatocellular carcinoma.	CYP3A7 CYP3A4	1.68e-05	2	143	2	27349315
Pubmed	ROCK1 via LIM kinase regulates growth, maturation and actin based functions in mast cells.	LIMK1 ROCK1	1.68e-05	2	143	2	26943578
Pubmed	CtIP protein dimerization is critical for its recruitment to chromosomal DNA double-stranded breaks.	RBBP8 ATM	1.68e-05	2	143	2	22544744
Pubmed	Constitutional translocation t(1;17)(p36.31-p36.13;q11.2-q12.1) in a neuroblastoma patient. Establishment of somatic cell hybrids and identification of PND/A12M2 on chromosome 1 and NF1/SCYA7 on chromosome 17 as breakpoint flanking single copy markers.	NBPF11 NBPF1	1.68e-05	2	143	2	7700633
Pubmed	Overexpression of kinase suppressor of Ras upregulates the high-molecular-weight tropomyosin isoforms in ras-transformed NIH 3T3 fibroblasts.	KSR1 ROCK1	1.68e-05	2	143	2	12588996
Pubmed	Co-expression of plexin-B1 and Met in human breast and ovary tumours enhances the risk of progression.	MET PLXNB1	1.68e-05	2	143	2	19940359
Pubmed	Both Talin-1 and Talin-2 correlate with malignancy potential of the human hepatocellular carcinoma MHCC-97 L cell.	TLN1 TLN2	1.68e-05	2	143	2	26822056
Pubmed	Extracellular rigidity sensing by talin isoform-specific mechanical linkages.	TLN1 TLN2	1.68e-05	2	143	2	26523364
Pubmed	Evidence of an odorant-binding protein in the human olfactory mucus: location, structural characterization, and odorant-binding properties.	OBP2B OBP2A	1.68e-05	2	143	2	12044155
Pubmed	Expression of Pfkfb isoenzymes during in vitro differentiation of mouse embryonic stem cells into insulin-producing cells.	PFKFB2 PFKFB3	1.68e-05	2	143	2	38813509
Pubmed	Differential regulation of CYP3A4 and CYP3A7 by dimethylsulfoxide in primary human hepatocytes.	CYP3A7 CYP3A4	1.68e-05	2	143	2	15379787
Pubmed	Overexpression of ubiquitous 6-phosphofructo-2-kinase in the liver of transgenic mice results in weight gain.	PFKFB2 PFKFB3	1.68e-05	2	143	2	17991424
Pubmed	ROCK I Has More Accurate Prognostic Value than MET in Predicting Patient Survival in Colorectal Cancer.	MET ROCK1	1.68e-05	2	143	2	26026086
Pubmed	ROCK1 and LIM kinase modulate retrovirus particle release and cell-cell transmission events.	LIMK1 ROCK1	1.68e-05	2	143	2	24696479
Pubmed	Role of Chromatin Structural Changes in Regulating Human CYP3A Ontogeny.	CYP3A7 CYP3A4	1.68e-05	2	143	2	26921389
Pubmed	Molecular mechanisms of polymorphic CYP3A7 expression in adult human liver and intestine.	CYP3A7 CYP3A4	1.68e-05	2	143	2	11940601
Pubmed	Plexin B1 suppresses c-Met in melanoma: a role for plexin B1 as a tumor-suppressor protein through regulation of c-Met.	MET PLXNB1	1.68e-05	2	143	2	20164843
Pubmed	New isoform-specific monoclonal antibodies reveal different sub-cellular localisations for talin1 and talin2.	TLN1 TLN2	1.68e-05	2	143	2	22306379
Pubmed	The Evi5 family in cellular physiology and pathology.	EVI5 EVI5L	1.68e-05	2	143	2	23669355
Pubmed	MCM10 overexpression implicates adverse prognosis in urothelial carcinoma.	MCM2 MCM10	1.68e-05	2	143	2	27780919
Pubmed	Xenopus Mcm10 binds to origins of DNA replication after Mcm2-7 and stimulates origin binding of Cdc45.	MCM2 MCM10	1.68e-05	2	143	2	11864598
Pubmed	Developmental regulation of CYP3A4 and CYP3A7 in Chinese Han population.	CYP3A7 CYP3A4	1.68e-05	2	143	2	27727071
Pubmed	Expression and cyclic variability of CYP3A4 and CYP3A7 isoforms in human endometrium and cervix during the menstrual cycle.	CYP3A7 CYP3A4	1.68e-05	2	143	2	12485945
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	KIF23 COPG1 ACVR1B HNRNPUL1 MCM10 TRIP11 RAB3C MET EEF1G IGF2BP1 DST SCLT1 RAB21	2.09e-05	777	143	13	35844135
Pubmed	Large-scale mapping of human protein-protein interactions by mass spectrometry.	CUL2 CDO1 KIF23 COPG1 NEK7 UFL1 COPS3 PFKFB3 HNRNPUL1 TRRAP FABP4 MET IGF2BP1 METTL13 VPS35 RTCA HERC2	2.26e-05	1284	143	17	17353931
Pubmed	A novel tandem affinity purification strategy for the efficient isolation and characterisation of native protein complexes.	KIF23 PFKFB2 TRIP11 KSR1 LIMK1	3.09e-05	87	143	5	17979178
Pubmed	Functional proteomics mapping of a human signaling pathway.	DOCK8 HNRNPUL1 GGA3 EEF1G DST AP1G1 VPS35 CHMP3 ROCK1 HERC2 UTRN	3.56e-05	591	143	11	15231748
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	PACSIN1 METTL13 DST TLN1 SETBP1 SYNE2 TLN2	4.29e-05	225	143	7	12168954
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	KIF23 LZTS3 TRIP11 RAB3C LUZP1 NOSIP NLGN3 DST PRRC2C SYNE2 ROCK1 TLN2 JAKMIP1 HERC2	4.63e-05	963	143	14	28671696
Pubmed	Nuclear actin interactome analysis links actin to KAT14 histone acetyl transferase and mRNA splicing.	LEO1 TRRAP LUZP1 EEF1G IGF2BP1 DST TLN1 CCT6B POTEJ UTRN	4.95e-05	506	143	10	30890647
Pubmed	Type I gamma phosphatidylinositol phosphate kinase targets and regulates focal adhesions.	TLN1 TLN2	5.02e-05	3	143	2	12422220
Pubmed	Hypoxic regulation of the 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase gene family (PFKFB-1-4) expression in vivo.	PFKFB2 PFKFB3	5.02e-05	3	143	2	14623077
Pubmed	Possible pheromone-carrier function of two lipocalin proteins in the vomeronasal organ.	OBP2B OBP2A	5.02e-05	3	143	2	7813422
Pubmed	UFL1 promotes histone H4 ufmylation and ATM activation.	UFL1 ATM	5.02e-05	3	143	2	30886146
Pubmed	The P450 oxidoreductase genotype is associated with CYP3A activity in vivo as measured by the midazolam phenotyping test.	CYP3A7 CYP3A4	5.02e-05	3	143	2	19801957
Pubmed	Cytochrome P450 3A gene variation, steroid hormone serum levels and prostate cancer--The Rotterdam Study.	CYP3A7 CYP3A4	5.02e-05	3	143	2	20621111
Pubmed	Functional link of BRCA1 and ataxia telangiectasia gene product in DNA damage response.	RBBP8 ATM	5.02e-05	3	143	2	10910365
Pubmed	ROCK1 but not LIMK1 or PAK2 is a key regulator of apoptotic membrane blebbing and cell disassembly.	LIMK1 ROCK1	5.02e-05	3	143	2	31043701
Pubmed	Adipose-derived lipocalin 14 alleviates hyperglycaemia by suppressing both adipocyte glycerol efflux and hepatic gluconeogenesis in mice.	OBP2B OBP2A	5.02e-05	3	143	2	26592241
Pubmed	Sema4D induces angiogenesis through Met recruitment by Plexin B1.	MET PLXNB1	5.02e-05	3	143	2	15632204
Pubmed	Glucose deprivation inhibits multiple key gene expression events and effector functions in CD8+ T cells.	TLN1 TLN2	5.02e-05	3	143	2	18792400
Pubmed	Arginylation-dependent regulation of a proteolytic product of talin is essential for cell-cell adhesion.	TLN1 TLN2	5.02e-05	3	143	2	22665520
Pubmed	Adipocyte fatty acid-binding protein (aP2), a newly identified LXR target gene, is induced by LXR agonists in human THP-1 cells.	FABP4 NR1H2	5.02e-05	3	143	2	17396233
Pubmed	An essential role for talin during alpha(M)beta(2)-mediated phagocytosis.	TLN1 TLN2	5.02e-05	3	143	2	17202407
Pubmed	The semaphorin 4D receptor controls invasive growth by coupling with Met.	MET PLXNB1	5.02e-05	3	143	2	12198496
Pubmed	Cytochrome P450 3As gene expression and testosterone 6 beta-hydroxylase activity in human fetal membranes and placenta at full term.	CYP3A7 CYP3A4	5.02e-05	3	143	2	20118548
Pubmed	ATM-dependent MiR-335 targets CtIP and modulates the DNA damage response.	RBBP8 ATM	5.02e-05	3	143	2	23696749
Pubmed	Effect of DNA damage on a BRCA1 complex.	RBBP8 ATM	5.02e-05	3	143	2	11689934
Pubmed	Increased expression and phosphorylation of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase isoforms in urinary exosomes in pre-eclampsia.	PFKFB2 PFKFB3	5.02e-05	3	143	2	30819197
Pubmed	ATM and MET kinases are synthetic lethal with nongenotoxic activation of p53.	MET ATM	5.02e-05	3	143	2	22660439
Pubmed	Prognostic significance of minichromosome maintenance mRNA expression in human lung adenocarcinoma.	MCM2 MCM10	5.02e-05	3	143	2	31545501
Pubmed	Regulation of the actin cytoskeleton by Rho kinase controls antigen presentation by CD1d.	LIMK1 ROCK1	5.02e-05	3	143	2	22798677
Pubmed	The interaction of CtIP and Nbs1 connects CDK and ATM to regulate HR-mediated double-strand break repair.	RBBP8 ATM	5.02e-05	3	143	2	23468639
Pubmed	Mechanotransduction in talin through the interaction of the R8 domain with DLC1.	TLN1 TLN2	5.02e-05	3	143	2	30028837
Pubmed	USP52 regulates DNA end resection and chemosensitivity through removing inhibitory ubiquitination from CtIP.	RBBP8 ATM	5.02e-05	3	143	2	33097710
Pubmed	Metabolic pathways of inhaled glucocorticoids by the CYP3A enzymes.	CYP3A7 CYP3A4	5.02e-05	3	143	2	23143891
Pubmed	Development of template systems for ligand interactions of CYP3A5 and CYP3A7 and their distinctions from CYP3A4 template.	CYP3A7 CYP3A4	5.02e-05	3	143	2	33866277
Pubmed	GGA3 functions as a switch to promote Met receptor recycling, essential for sustained ERK and cell migration.	GGA3 MET	5.02e-05	3	143	2	21664574
Pubmed	Vinculin and talin: focus on the myocardium.	TLN1 TLN2	5.02e-05	3	143	2	19952892
Pubmed	Contribution of three CYP3A isoforms to metabolism of R- and S-warfarin.	CYP3A7 CYP3A4	5.02e-05	3	143	2	20615193
Pubmed	Effects of hypoxia-inducible factor-1α chemical stabilizer, CoCl(2) and hypoxia on gene expression of CYP3As in human fetal liver cells.	CYP3A7 CYP3A4	5.02e-05	3	143	2	22277676
Pubmed	Talin depletion reveals independence of initial cell spreading from integrin activation and traction.	TLN1 TLN2	5.02e-05	3	143	2	19160486
GeneFamily	Neuroblastoma breakpoint family	NBPF12 NBPF11 NBPF1 NBPF19 NBPF15 NBPF9 NBPF10	1.27e-11	23	89	7	662
GeneFamily	6-phosphofructo-2-kinases/fructose-2,6-biphosphatases	PFKFB2 PFKFB3	1.43e-04	4	89	2	1077
GeneFamily	Cytochrome P450 family 3	CYP3A7 CYP3A4	6.58e-04	8	89	2	1002
GeneFamily	ATPase phospholipid transporting	ATP8B4 ATP8B1	2.41e-03	15	89	2	1210
GeneFamily	Zinc fingers ZZ-type\|Lysine acetyltransferases	HERC2 UTRN	3.48e-03	18	89	2	91
GeneFamily	Lipocalins	OBP2B OBP2A	3.88e-03	19	89	2	631
GeneFamily	Protein phosphatase catalytic subunits\|STRIPAK complex	SIKE1 FGFR1OP2	4.30e-03	20	89	2	1371
Coexpression	GSE16451_CTRL_VS_WEST_EQUINE_ENC_VIRUS_IMMATURE_NEURON_CELL_LINE_UP	GPD2 ATP8B4 CMC1 HDDC2 ACVR1B EEF1G METTL13 UCHL3 LEF1	1.62e-06	200	143	9	M7427
Coexpression	GRYDER_PAX3FOXO1_ENHANCERS_IN_TADS	VAPA ATP8B4 RBBP8 MCM2 COPS3 IDH3A ARMC1 NOSIP MET SLC7A1 METTL13 ACAD8 MYH14 FRG1 SETBP1 CDYL HERC2 TRIM44 SLC16A10	2.59e-06	1009	143	19	M157
Coexpression	PUJANA_BRCA2_PCC_NETWORK	KIF23 RBBP8 MCM2 COPS3 HNRNPUL1 TRRAP SLC7A1 FRG1 RTCA LEF1 CNOT3 VAV1	4.07e-06	426	143	12	M9516
Coexpression	DACOSTA_UV_RESPONSE_VIA_ERCC3_DN	CUL2 KIF23 NEK7 ATP8B1 RABGAP1 TRRAP SNX13 EVI5 SLC7A1 DST PRRC2C SYNE2 ROCK1 CDYL RAB21 TRIM44	1.86e-05	856	143	16	M4500
Coexpression	GSE40274_CTRL_VS_FOXP3_AND_SATB1_TRANSDUCED_ACTIVATED_CD4_TCELL_DN	MICAL1 PACSIN1 DGKD ATP8B1 ACVR1B FAM162B TLN1	3.25e-05	163	143	7	M9115
Coexpression	PUJANA_XPRSS_INT_NETWORK	RBBP8 MCM2 COPS3 SLC7A1 FRG1 ATM CNOT3	3.95e-05	168	143	7	M18811
Coexpression	PUJANA_BRCA_CENTERED_NETWORK	RBBP8 MCM2 COPS3 SLC7A1 ATM CNOT3	4.74e-05	118	143	6	M15305
Coexpression	MURARO_PANCREAS_BETA_CELL	RBBP8 DGKD PFKFB2 ACVR1B SCGN TRIP11 CDC37L1 ITPR3 SLC7A1 DST MYH14 SETBP1 SYNE2 VPS35 ROCK1 UTRN	6.16e-05	946	143	16	M39169
Coexpression	GSE38696_LIGHT_ZONE_VS_DARK_ZONE_BCELL_UP	ATP8B4 ERCC5 DGKD ATM HERC2 UTRN VAV1	7.02e-05	184	143	7	M9005
Coexpression	CUI_DEVELOPING_HEART_CORONARY_VASCULAR_ENDOTHELIAL_CELL	FABP4 DST UTRN CAVIN2	7.35e-05	41	143	4	M39320
Coexpression	GSE360_L_MAJOR_VS_B_MALAYI_HIGH_DOSE_DC_DN	DGKD IP6K1 UFL1 RABGAP1 TRRAP RTCA ROCK1	1.08e-04	197	143	7	M5210
Coexpression	GSE17721_POLYIC_VS_GARDIQUIMOD_24H_BMDC_DN	MCM2 SMARCAD1 ARMC1 MET LIMK1 EEF1G PDCL	1.14e-04	199	143	7	M4036
Coexpression	GSE7852_TREG_VS_TCONV_THYMUS_DN	SIKE1 PFKFB2 ACVR1B CDC37L1 NRK FGA CNOT3	1.14e-04	199	143	7	M5732
Coexpression	GSE17721_CTRL_VS_CPG_1H_BMDC_UP	VAPA NCKIPSD MCM2 HNRNPUL1 LIMK1 AP1G1 TLN1	1.18e-04	200	143	7	M3756
Coexpression	GSE360_DC_VS_MAC_L_DONOVANI_UP	GAK RBBP8 SLC7A1 AP1G1 TLN2 LEF1 DNASE1L3	1.18e-04	200	143	7	M5174
Coexpression	GSE40068_CXCR5POS_BCL6POS_TFH_VS_CXCR5NEG_BCL6NEG_CD4_TCELL_DN	GPD2 BEND5 PACSIN1 DGKD ACVR1B LEF1 SLC16A10	1.18e-04	200	143	7	M9262
Coexpression	GSE12845_IGD_POS_BLOOD_VS_PRE_GC_TONSIL_BCELL_DN	KIF23 RBBP8 MCM10 ITPR3 ODR4 PRRC2C ROCK1	1.18e-04	200	143	7	M3188
Coexpression	LI_ADIPOGENESIS_BY_ACTIVATED_PPARG	GPD2 FABP4 NR1H2	1.22e-04	18	143	3	M1645
Coexpression	LI_ADIPOGENESIS_BY_ACTIVATED_PPARG	GPD2 FABP4 NR1H2	1.45e-04	19	143	3	MM1202
CoexpressionAtlas	DevelopingLowerUrinaryTract_e15.5_Urothelium_emap-28091_top-relative-expression-ranked_1000	VAPA CDO1 DOCK8 RBBP8 ZBTB8B CLEC1A DGKD ATP8B1 RABGAP1 FABP4 MET DST VPS35 JAKMIP1 HERC2 UTRN PLXNB1	1.37e-05	784	138	17	gudmap_developingLowerUrinaryTract_e15.5_urothelium_1000
ToppCell	PND10-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ATP8B1 RABGAP1 LUZP1 ITPR3 DST DHH UTRN CAVIN2	1.43e-07	183	143	8	3427f3cbe6ea81709750e7dd3ff378f03ae65eab
ToppCell	ILEUM-inflamed-(3)_MNP-(3)_moDC\|(3)_MNP / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	ATP8B4 MCM2 HNRNPUL1 DST ROCK1 ATM UTRN DNASE1L3	1.69e-07	187	143	8	0099def970fbc828756fbf853eca2ce77b8cd342
ToppCell	PND03-Endothelial-Endothelial_blood-vessel-Macrovascular_EC\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ATP8B1 LUZP1 FABP4 DST DHH KCNH1 UTRN CAVIN2	2.15e-07	193	143	8	58c590dd6f21bc7ae58ae1729dd574c0f1069592
ToppCell	PND14-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ATP8B1 RABGAP1 DST DHH SYNE2 UTRN CAVIN2	1.12e-06	166	143	7	7a45785a40b7425f97be67bab1c5ceb69b2bd85a
ToppCell	PND14-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_mature\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ATP8B1 RABGAP1 DST DHH SYNE2 UTRN CAVIN2	1.12e-06	166	143	7	bbd382812f8a84a5d99888de2d7cca3a8b5e4695
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW23-Mesenchymal-Unfolded_protein_responsible_cell\|GW23 / Sample Type, Dataset, Time_group, and Cell type.	ERCC5 COPG1 MET IGF2BP1 MYH14 NBPF9	1.29e-06	107	143	6	7fee0193ee02e9cc62f506660ea7ec23fb4d0c84
ToppCell	droplet-Marrow-nan-3m\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DOCK8 HNRNPUL1 TRIP11 PRRC2C TLN1 LEF1 UTRN	2.23e-06	184	143	7	1154a5ad7b8512272b7476f949ddac350910bfb7
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Epithelial-neuro-epithelial-EECs\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	IFFO1 SCGN RAB3C GGA3 MET GALNT8 PLXNB1	2.31e-06	185	143	7	d42f6722a6771752cd744146a09e2ead9b7252bc
ToppCell	PND10-Endothelial-Endothelial_blood-vessel-Macrovascular_EC\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ATP8B1 LUZP1 FABP4 DST DHH UTRN CAVIN2	2.86e-06	191	143	7	b270c3dd5952f56b9bdceabe13e298fe6757563b
ToppCell	PND03-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_mature\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ATP8B1 RABGAP1 ITPR3 DST DHH UTRN CAVIN2	2.96e-06	192	143	7	285a9d332a1e07b94f222d4b518dd56928b9e075
ToppCell	severe-pDC\|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	PACSIN1 PFKFB2 IDH3A KCNH1 SETBP1 CDYL DNASE1L3	3.63e-06	198	143	7	22da4a29b9ff8b94d98bc69b4632a2a58d5dd9e6
ToppCell	mild\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	DOCK8 PRRC2C SYNE2 ROCK1 ATM UTRN TRIM44	3.87e-06	200	143	7	12f1685ce8f218433068e090c9d839cd5a1910bf
ToppCell	(08)_Brush+PNEC-(2)_GFP_FOXI1\|(08)_Brush+PNEC / shred by cell type by condition	TRIP11 LUZP1 PRRC2C SYNE2 ROCK1 CAVIN2	5.65e-06	138	143	6	817e3f639604ea95adae01e8685ffaa2e0aff7a8
ToppCell	PND03-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC-VEC_prolif\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MCM2 FABP4 SLC7A1 DHH KCNH1 CAVIN2	1.36e-05	161	143	6	f4f5d6eaa32169de699c8ff8e8ae35179c8e25c0
ToppCell	Control-B_intermediate-1\|Control / disease group and sub_cluster of B and Plasma cells(res = 0.5)	NBPF12 ERCC5 NBPF11 NBPF1 NBPF15 NBPF10	1.68e-05	167	143	6	948504367ecf58144d9dd74d2ec531358fc4b309
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_2-Exc_L3-4_RORB_SEMA6D\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CCDC168 FAM162B NBPF19 MET KCNH1 UTRN	2.05e-05	173	143	6	9a2d42f8d9cb834856522661d524abb91c4637c5
ToppCell	metastatic_Brain-Endothelial_cells-Stalk-like_ECs\|Endothelial_cells / Location, Cell class and cell subclass	CDO1 NEK7 URGCP GGA3 NBPF19 NBPF15	2.18e-05	175	143	6	f6a6db992e803d36c866a91706b02f67e0fd3e09
ToppCell	droplet-Limb_Muscle-MUSCLE-30m-Endothelial\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PFKFB3 LUZP1 FABP4 SYNE2 UTRN CAVIN2	2.33e-05	177	143	6	ca5a30b3e7bcfdd8de01ceaf7449735b5cd503af
ToppCell	droplet-Limb_Muscle-MUSCLE-30m-Endothelial-nan\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PFKFB3 LUZP1 FABP4 SYNE2 UTRN CAVIN2	2.33e-05	177	143	6	f471f7747d6e8db7546899019af9508f48a14f89
ToppCell	droplet-Limb_Muscle-MUSCLE-30m-Endothelial-endothelial_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PFKFB3 LUZP1 FABP4 SYNE2 UTRN CAVIN2	2.33e-05	177	143	6	cd0684b876c2a7d5fe7e2773e8e25bb61ecbc795
ToppCell	droplet-Limb_Muscle-MUSCLE-30m\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TRIP11 LUZP1 PRRC2C SYNE2 UTRN CAVIN2	2.40e-05	178	143	6	01dafd19de04eff459253eaa9a35debf8f3deedf
ToppCell	facs-Diaphragm-Limb_Muscle-18m\|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KIF23 ATP8B4 MCM2 MCM10 DNASE1L3 VAV1	2.40e-05	178	143	6	40bd605b801d9ae76cffc8f62836092fc2b06812
ToppCell	COVID-19_Convalescent-PLT_1\|World / Disease Group and Platelet Clusters	GPD2 MAT2B NBPF11 EEF1G NBPF9 CDYL	2.48e-05	179	143	6	d0f2764c6fc5d61fd69e9231b3603a80ac373f65
ToppCell	PND10-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_mature\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ATP8B1 RABGAP1 LUZP1 DST UTRN CAVIN2	2.64e-05	181	143	6	4d7793026373cbcf04b15c77f95f1025d07d4c00
ToppCell	wk_15-18-Epithelial-Distal_epithelial_progenitor-epi-tip_intermediate\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	PFKFB2 SLC7A1 CCDC144A EVI5L SLC16A10 RAB11FIP3	2.98e-05	185	143	6	636505a3d96f75d951ab42bcf8af6ae07abc732d
ToppCell	droplet-Heart-nan-3m-Endothelial\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HNRNPUL1 PRRC2C NRK SYNE2 UTRN CAVIN2	3.08e-05	186	143	6	0ae5fbe9f210cb25092394267e1d3d6ed05627b8
ToppCell	COVID-19_Severe-pDC-\|COVID-19_Severe / Disease condition and Cell class	PACSIN1 PFKFB2 IDH3A SETBP1 DNASE1L3 LRRC36	3.27e-05	188	143	6	9fd1116e31a05554850b8ed3c005ea660dfbd51c
ToppCell	droplet-Kidney-nan-3m-Endothelial-kidney_cortex_artery_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OBP2B CLEC1A DHH LEF1 CAVIN2 SPINK5	3.27e-05	188	143	6	67c04f446fa4528b13a381622e88eb1f314cc6d5
ToppCell	droplet-Kidney-nan-3m-Endothelial-Pecam____Kidney_cortex_artery_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OBP2B CLEC1A DHH LEF1 CAVIN2 SPINK5	3.27e-05	188	143	6	03a7f6538cfddc230c0eab10c3613929addd7e33
ToppCell	COVID-19_Severe-pDC\|COVID-19_Severe / Disease condition and Cell class	PACSIN1 PFKFB2 IDH3A SETBP1 DNASE1L3 LRRC36	3.27e-05	188	143	6	475008f45673b42b75ef231c2df91f8b9adc9201
ToppCell	PND03-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	RABGAP1 ITPR3 DST DHH UTRN CAVIN2	3.46e-05	190	143	6	d87b9e9ca863270a9c7f61674271a6440c97d1f4
ToppCell	droplet-Large_Intestine-COLON_PROXIMAL\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FGFR1OP2 SMARCAD1 HNRNPUL1 TRIP11 PRRC2C SYNE2	3.57e-05	191	143	6	60c986d2dcbc19d9338c03da6cb5e1d92fd48f8e
ToppCell	(011)_pDC\|World / immune cells in Peripheral Blood (logTPM normalization)	PACSIN1 PFKFB2 IDH3A SETBP1 DNASE1L3 LRRC36	3.57e-05	191	143	6	d82ac4f6d9863734e09bf3cb71c1354a49b66b4f
ToppCell	facs-Pancreas-Endocrine-3m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ATP8B1 PFKFB2 SCGN DST JAKMIP1 SLC16A10	3.57e-05	191	143	6	f76f3f5c7902a3659d8cbe470f96ce57c8a6744d
ToppCell	PND07-Endothelial-Endothelial_blood-vessel-Macrovascular_EC\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ATP8B1 FABP4 DHH KCNH1 UTRN CAVIN2	3.57e-05	191	143	6	27f23c2254b610abac1a88d0fecff305addde9da
ToppCell	P07-Endothelial-large_vessel_endothelial_cell\|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	ATP8B1 FABP4 DST DHH UTRN CAVIN2	3.57e-05	191	143	6	d162917816dd2e4767c97447c1cddae9397713ab
ToppCell	droplet-Large_Intestine-COLON_PROXIMAL-30m\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FGFR1OP2 SMARCAD1 HNRNPUL1 TRIP11 PRRC2C SYNE2	3.57e-05	191	143	6	973117730d6ba5f127e7a0bfabfd0ff2ca7ac131
ToppCell	10x3'2.3-week_14-16-Myeloid_DC-DC-pDC\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	PACSIN1 PFKFB2 IDH3A SETBP1 DNASE1L3 LRRC36	3.78e-05	193	143	6	2c35aadc397e7e365c3daf8017ae1d3bd045f305
ToppCell	Control-Myeloid-ncMonocyte\|Myeloid / Disease state, Lineage and Cell class	PFKFB3 LINC00173 SETBP1 SCLT1 UTRN VAV1	3.78e-05	193	143	6	3479c01aaae7afd7e02d00e0cb21951c0106a0fd
ToppCell	VE-pDC-\|VE / Condition, Cell_class and T cell subcluster	PACSIN1 PFKFB2 IDH3A SETBP1 DNASE1L3 LRRC36	3.78e-05	193	143	6	583724de588fcde3aeda056138c522dc0225a387
ToppCell	VE-pDC\|VE / Condition, Cell_class and T cell subcluster	PACSIN1 PFKFB2 IDH3A SETBP1 DNASE1L3 LRRC36	3.78e-05	193	143	6	bb759dc9ef0ec41d655002f59021d62d62d44289
ToppCell	droplet-Limb_Muscle-MUSCLE\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PFKFB3 TRIP11 LUZP1 PRRC2C UTRN CAVIN2	3.89e-05	194	143	6	e3d63874111d1e8da3977329426e4dcf68d6de87
ToppCell	Control-Myeloid-ncMonocyte\|Control / Disease state, Lineage and Cell class	PFKFB3 NBPF19 LINC00173 SCLT1 UTRN VAV1	4.01e-05	195	143	6	fcb05948e7480dc53f06f3fc9b9c3fc129874edd
ToppCell	Control-Myeloid-ncMonocyte\|World / Disease state, Lineage and Cell class	PFKFB3 NBPF19 LINC00173 SCLT1 UTRN VAV1	4.01e-05	195	143	6	b4444b67a709e82b8e2ee510924c3152cb88b051
ToppCell	mild-pDC\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	PACSIN1 PFKFB2 IDH3A SETBP1 CDYL DNASE1L3	4.24e-05	197	143	6	0cb00daa6943f7a7fb34a8fdf51188646af65686
ToppCell	PBMC-Convalescent-Lymphocyte-T/NK\|Convalescent / Location, Disease Group, Cell group, Cell class (2021.03.09)	CMC1 NOSIP EEF1G SYNE2 ATM LEF1	4.36e-05	198	143	6	24f6954aff8751885e783d68c631b04dd1980f48
ToppCell	PBMC-Convalescent-Lymphocyte-T/NK\|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	CMC1 NOSIP EEF1G SYNE2 ATM LEF1	4.36e-05	198	143	6	4633e379893a26a746f8e29302cc54bbe04dd23f
ToppCell	severe-pDC\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	PACSIN1 PFKFB2 IDH3A SETBP1 CDYL DNASE1L3	4.36e-05	198	143	6	3c4820a8391088682fb3e47b914f872533bae227
ToppCell	COVID-19_Convalescent-Lymphoid_T/NK\|COVID-19_Convalescent / Disease group, lineage and cell class	CMC1 NOSIP EEF1G SYNE2 ATM LEF1	4.36e-05	198	143	6	457ba9e3f1bb6453af8cc1a6e7436af66296f8f5
ToppCell	(03)_KRT6B+-(2)_GFP_FOXI1\|(03)_KRT6B+ / shred by cell type by condition	TRIP11 DST PRRC2C SYNE2 ROCK1 UTRN	4.48e-05	199	143	6	c425e7975f492ed5cfcca022248adb627e1d27d4
ToppCell	(05)_Secretory-(2)_GFP_FOXI1\|(05)_Secretory / shred by cell type by condition	TRIP11 LUZP1 PRRC2C SYNE2 ROCK1 CAVIN2	4.48e-05	199	143	6	d72d87e1e530ed894c0ad5e7b5b2b1d6b59fa098
ToppCell	367C-Endothelial_cells-Endothelial-A_(Artery)\|367C / Donor, Lineage, Cell class and subclass (all cells)	CLEC1A ATP8B1 RAB3C MET DNASE1L3 CAVIN2	4.48e-05	199	143	6	29ed081bd5204a32068b420f2244f3704891547b
ToppCell	367C-Endothelial_cells-Endothelial-A_(Artery)-\|367C / Donor, Lineage, Cell class and subclass (all cells)	CLEC1A ATP8B1 RAB3C MET DNASE1L3 CAVIN2	4.48e-05	199	143	6	c2d85f80037f209a4a329790f475d9f98f590262
ToppCell	COVID-19-COVID-19_Mild-Lymphocyte-T/NK-dn_T\|COVID-19_Mild / Disease, condition lineage and cell class	PACSIN1 ITPR3 NOSIP SYNE2 JAKMIP1 LEF1	4.48e-05	199	143	6	f307d4887b28cf60a591439e278fd668409cb104
ToppCell	Control-Control-Lymphocyte-T/NK-dn_T\|Control / Disease, condition lineage and cell class	PACSIN1 NOSIP MET SYNE2 JAKMIP1 LEF1	4.61e-05	200	143	6	10882c59b7aaf8bd4b5c00aa4ddbb9f7ac5b2cf5
ToppCell	390C-Endothelial_cells-Endothelial-A_(Artery)-\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	ATP8B1 RAB3C PRRC2C MAP3K13 LEF1 DNASE1L3	4.61e-05	200	143	6	50b8788494b744e0f0ec8c4d67a1c90ae09dca65
ToppCell	390C-Endothelial_cells-Endothelial-A_(Artery)\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	ATP8B1 RAB3C PRRC2C MAP3K13 LEF1 DNASE1L3	4.61e-05	200	143	6	f5f24273bee3259a4a3be99ba53b88defa1286c0
ToppCell	PBMC-Mild-Myeloid-Neutrophil-immature_Neutrophil-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	KIF23 MCM2 MCM10 GALNT8 PLXNB1	9.55e-05	142	143	5	e160f35b3c18e77c4107fe96db5f56227c91785e
ToppCell	Mild/Remission-B_naive-1\|Mild/Remission / disease group and sub_cluster of B and Plasma cells(res = 0.5)	NBPF11 NBPF1 NBPF15 EEF1G NBPF10	9.87e-05	143	143	5	bd3f5fbd4e9e4dc414682db5607494f3ce988deb
ToppCell	Control-B_intermediate-1\|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)	NBPF12 NBPF11 NBPF1 NBPF15 NBPF10	1.02e-04	144	143	5	984470ff6ddce4c743e2db78fa98dae055aaa273
ToppCell	PBMC-Mild-Lymphocyte-T/NK-CD4+_T-Treg-Treg_2\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	CDRT4 NRK SYNE2 LEF1 SLC16A10	1.05e-04	145	143	5	734d85ca7a2e5e040f433cadc5f9be1f25cf2e91
ToppCell	PBMC-Mild-Lymphocyte-T/NK-CD4+_T-Treg-Treg_2\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	CDRT4 NRK SYNE2 LEF1 SLC16A10	1.05e-04	145	143	5	8ba09eb0fd27f25aa90a3ad75d67a9f79f3f4f43
ToppCell	ICU-SEP-Lymphocyte-T_NK-CD8_Naive\|ICU-SEP / Disease, Lineage and Cell Type	CYP3A4 RAB3C NOSIP CEP70 LEF1	1.20e-04	149	143	5	a66f3ebf6214b269b137ddd5f4d8d7fb3ef2d962
ToppCell	3'_v3-lymph-node_spleen-Lymphocytic_B-GC_B_(II)\|lymph-node_spleen / Manually curated celltypes from each tissue	KSR1 IGF2BP1 GZF1 LINC00173 CCDC144A	1.31e-04	152	143	5	4f690aed23338687bdefc47e8a2f3d1fdb2b6447
ToppCell	E15.5-Mesenchymal-developing_mesenchymal_cell-mesenchymal_immature_unknown_1\|E15.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	CCDC85C FABP4 DHH SETBP1 CAVIN2	1.40e-04	154	143	5	e65e4636646164610f33f7bbac0d879a3ea55986
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d14-21-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c09-SLC4A10\|Severe-critical_convalescent_d14-21 / Compartment, severity and other cell annotations on 10x 3' data (130k)	GAK CMC1 SYNE2 TLN2 JAKMIP1	1.40e-04	154	143	5	e94cd11488003347120eacd3ced0a8923ed09ccc
ToppCell	severe_influenza-CD8+_T_naive\|severe_influenza / disease group, cell group and cell class (v2)	BEND5 ZBTB8B CDC37L1 CEP70 LEF1	1.72e-04	161	143	5	82196139cdbbd70a36957a87bc9ac6d02575da3f
ToppCell	normal-na-Lymphocytic_NK-NK_bright-male\|normal / PBMC cell types (v2) per disease, treatment status, and sex	CMC1 PACSIN1 TLN1 ATM UTRN	1.87e-04	164	143	5	b5a91f2cbfad9a2bc38aea576085a37865df955d
ToppCell	LV-13._Vascular_Smooth_Muscle\|World / Chamber and Cluster_Paper	OBP2A DOCK8 RABGAP1 ROCK1 UTRN	1.93e-04	165	143	5	f37fd95adc95d7753cf6e55ae819976513c7ec77
ToppCell	droplet-Lung-nan-18m-Lymphocytic-Zbtb32+_B\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BEND5 DGKD UCHL3 JAKMIP1 DNASE1L3	1.98e-04	166	143	5	3e3e9296e6919a38602e417a6606c046af3bd101
ToppCell	droplet-Lung-18m-Hematologic-lymphocytic-Zbtb32+_B_cell-Zbtb32+_B_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	BEND5 DGKD UCHL3 JAKMIP1 DNASE1L3	2.04e-04	167	143	5	3c3e1c31aacca48099693aea2efdfa22fc0e4af4
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_2-Exc_L3-4_RORB_PRSS12\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	BEND5 CCDC168 FAM162B NBPF19 MET	2.04e-04	167	143	5	cb650f74306fa0d9f4bf49890b73065d193b94dc
ToppCell	droplet-Lung-18m-Hematologic-lymphocytic-Zbtb32+_B_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	BEND5 DGKD UCHL3 JAKMIP1 DNASE1L3	2.04e-04	167	143	5	77a4d7ce44847c76074d4f5340d61b398fe43e6c
ToppCell	systemic_lupus_erythematosus-flare-Lymphocytic_T-CD4-positive,_alpha-beta_T_cell-male\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	NOSIP SYNE2 ATM LEF1 CAVIN2	2.10e-04	168	143	5	5e721268f0baa51d3f640f7f4c41db769ebef210
ToppCell	facs-Lung-24m-Hematologic-lymphocytic-CD8-positive,_alpha-beta_T_cell-CD8-positive,_alpha-beta_T_cell_l5\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	OBP2B PACSIN1 SCGN JAKMIP1 LEF1	2.15e-04	169	143	5	a388e53deac861a185c31e9cceddae7bcb344700
ToppCell	Smart-seq2-tissue-resident_(Smart-seq2)-myeloid-myeloid_dendritic-CD1c-positive_myeloid_dendritic_cell\|tissue-resident_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	CLEC1A PFKFB3 DHH MAP3K13 SLC16A10	2.21e-04	170	143	5	cc66ac6846c58be9493eb270644ee3ce0f86cfea
ToppCell	droplet-Liver-LIVER-NPC-1m-Lymphocytic-macrophage/monocyte\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OBP2B PACSIN1 DGKD JAKMIP1 LEF1	2.21e-04	170	143	5	3ad9f950b87ee98f025ab9b4a8ed551e6a9b4764
ToppCell	PBMC-Control-Lymphocyte-B-Plasmablast-Plasmablast-Developping_Plasmablast\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	KIF23 MCM2 MCM10 MET SLC7A1	2.27e-04	171	143	5	13126a3fbee181412c13ffb0c347277b9d8f16f7
ToppCell	COVID_vent-Lymphocytic-Dendritic-pDC\|COVID_vent / Disease condition, Lineage, Cell class and subclass	PACSIN1 PFKFB2 IDH3A DNASE1L3 LRRC36	2.27e-04	171	143	5	779c951d274ecbd1d546ac425d6c8e718623be5a
ToppCell	3'_v3-lymph-node_spleen-Lymphocytic_T_CD4-T_CD4/CD8\|lymph-node_spleen / Manually curated celltypes from each tissue	PRRC2C SYNE2 ATM UTRN CCDC144A	2.27e-04	171	143	5	2e9a20f8980b78325c52065a9c14ab3656267c05
ToppCell	COVID_vent-Lymphocytic-Dendritic\|COVID_vent / Disease condition, Lineage, Cell class and subclass	PACSIN1 PFKFB2 IDH3A DNASE1L3 LRRC36	2.27e-04	171	143	5	debbb071d260639b16269c94d172766908325c58
ToppCell	E15.5-Endothelial-large_vessel_endothelial_cell-endothelial_cell_of_vein\|E15.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	FABP4 DST DHH KCNH1 CAVIN2	2.27e-04	171	143	5	3112d15f2a28cf4a71992db4971d960716dc1264
ToppCell	5'-GW_trimst-2-SmallIntestine-Hematopoietic-Myeloid-pDC\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PACSIN1 CCDC168 IDH3A DNASE1L3 LRRC36	2.34e-04	172	143	5	b84610f1e5889a655652800c2b3270d264bfe1a9
ToppCell	E16.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC-VEC_prolif\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FABP4 MET SLC7A1 CAVIN2 RAB11FIP3	2.34e-04	172	143	5	8a6a2b4c6654bc976e60a02d0e7303a9071ed55f
ToppCell	E16.5-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_mature\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DOCK8 NCKIPSD FABP4 VAV1 SLC16A10	2.40e-04	173	143	5	20f7dfe7d92a3dbec9da9a1f3185aa10cb8f0a3c
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_2-Exc_L3-4_RORB_PRSS12\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CCDC168 FAM162B NBPF19 MET NBPF10	2.40e-04	173	143	5	8ac2e9d39c0f76e674f8bd59d1da246bab4867c8
ToppCell	10x5'-Liver-Lymphocytic_T_CD8-Tnaive/CM_CD8\|Liver / Manually curated celltypes from each tissue	LZTS3 ZBTB8B NOSIP EEF1G LEF1	2.47e-04	174	143	5	03918ca51ae3b4c9c1a74769b08ea23f518286ba
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_2\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CCDC168 FAM162B NBPF19 MET KCNH1	2.47e-04	174	143	5	b3cd22e717d178269e6d5bd5ed7b2d945cd8ea25
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_2-Exc_L3-4_RORB_PRSS12\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CCDC168 FAM162B NBPF19 MET UTRN	2.47e-04	174	143	5	ae363ce736fc8af439f3ad594d7bc2e344db80d4
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical-aged\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CDO1 DOCK8 FAM162B FABP4 PCDH18	2.53e-04	175	143	5	1b4cefae400bf756d09ece32d3f5c0bd4c6ad73f
ToppCell	PBMC-Severe-Lymphocyte-T/NK-NK_cell-NK_CD56bright-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	ATP8B4 CMC1 PACSIN1 DST ATM	2.53e-04	175	143	5	0ed053aa8353c72ff37fee830672704a3ddc7d85
ToppCell	PBMC-Severe-Lymphocyte-T/NK-NK_cell-NK_CD56bright\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	ATP8B4 CMC1 PACSIN1 DST ATM	2.53e-04	175	143	5	0124a3c4696b39cee8b566e94603d1d3d128bfa5
ToppCell	BAL-Control-cDC_11\|Control / Compartment, Disease Groups and Clusters	BEND5 CLEC1A FABP4 EEF1G DNASE1L3	2.53e-04	175	143	5	daf014e15a354956e9149c83fd89d0af0d07eb00
ToppCell	PBMC-Severe-Lymphocyte-T/NK-NK_cell-NK_CD56bright\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	ATP8B4 CMC1 PACSIN1 DST ATM	2.53e-04	175	143	5	e219b61d6bc078d44ea7d06191d3462654d857a1
ToppCell	PBMC-Severe-Lymphocyte-T/NK-NK_cell-NK_CD56bright-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	ATP8B4 CMC1 PACSIN1 DST ATM	2.53e-04	175	143	5	bd16c80418bf71127e6f1e50edf83967c9218b42
ToppCell	normal_Lymph_Node-B_lymphocytes-GrB-secreting_B_cells\|normal_Lymph_Node / Location, Cell class and cell subclass	PACSIN1 PFKFB2 TLN2 DNASE1L3 LRRC36	2.53e-04	175	143	5	29fbdfe1d3bfcb063be2bced0128a33176c5b78f
ToppCell	normal_Lymph_Node-Myeloid_cells-pDCs\|normal_Lymph_Node / Location, Cell class and cell subclass	PACSIN1 PFKFB2 PFKFB3 DST SETBP1	2.60e-04	176	143	5	476794ef75ce5ab732d78cfeb4944e2f841e3e92
ToppCell	B_cells-pDCs\|B_cells / Immune cells in Kidney/Urine in Lupus Nephritis	PACSIN1 PFKFB2 DST DNASE1L3 LRRC36	2.60e-04	176	143	5	ce757de9e09a225f3f96433f103f43619b0e0dda
ToppCell	droplet-Lung-LUNG-1m-Lymphocytic-CD8+_T\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OBP2B PACSIN1 SCGN JAKMIP1 LEF1	2.60e-04	176	143	5	4478b3284201220e902bd2077960dc0d4d4a2c7c
ToppCell	normal_Lymph_Node-B_lymphocytes-GrB-secreting_B_cells\|B_lymphocytes / Location, Cell class and cell subclass	PACSIN1 PFKFB2 TLN2 DNASE1L3 LRRC36	2.60e-04	176	143	5	d6e660df92a3d7dd5732171ee623763faf108476
Drug	Pesticides	NBPF12 CYP3A4 NBPF11 FABP4 NBPF1 NBPF15 NBPF9 NBPF10 NR1H2	4.10e-07	150	141	9	ctd:D010575
Disease	tacrolimus measurement	CYP3A7 CYP3A4	1.26e-04	4	136	2	EFO_0008458
Disease	estrone conjugate measurement	CYP3A7 CYP3A4	1.26e-04	4	136	2	EFO_0007971
Disease	tauro-beta-muricholate measurement	CYP3A7 CYP3A4	2.09e-04	5	136	2	EFO_0800213
Disease	glyco-beta-muricholate measurement	CYP3A7 CYP3A4	2.09e-04	5	136	2	EFO_0800569
Disease	odorant-binding protein 2b measurement	OBP2B OBP2A	2.09e-04	5	136	2	EFO_0801859
Disease	stem Cell Growth Factor-beta measurement	ATP8B4 RAB11FIP3	2.09e-04	5	136	2	EFO_0802090
Disease	dehydroisoandrosterone sulfate DHEA-S measurement	CYP3A7 CYP3A4	3.13e-04	6	136	2	EFO_0021119
Disease	androstenediol (3beta,17beta) monosulfate (1) measurement	CYP3A7 CYP3A4	3.13e-04	6	136	2	EFO_0800294
Disease	X-24574 measurement	CYP3A7 CYP3A4	4.36e-04	7	136	2	EFO_0800897
Disease	Malignant neoplasm of breast	MICAL1 CYP3A4 ATP8B1 FABP4 GGA3 KCNH1 SETBP1 SYNE2 MAP3K13 ATM HERC2 LEF1 DNASE1L3 PLXNB1	4.54e-04	1074	136	14	C0006142
Disease	androstenediol (3beta,17beta) disulfate (1) measurement	CYP3A7 CYP3A4	7.43e-04	9	136	2	EFO_0800278
Disease	nevus count, cutaneous melanoma	DOCK8 SYNE2 ATM HERC2	8.46e-04	91	136	4	EFO_0000389, EFO_0004632
Disease	Neurodevelopmental Disorders	DOCK8 KCNH1 SETBP1 PLXNB1	9.18e-04	93	136	4	C1535926
Disease	4-androsten-3alpha,17alpha-diol monosulfate (3) measurement	CYP3A7 CYP3A4	9.26e-04	10	136	2	EFO_0022090
Disease	5alpha-androstan-3beta,17alpha-diol disulfate measurement	CYP3A7 CYP3A4	9.26e-04	10	136	2	EFO_0800289
Disease	Adenocarcinoma of large intestine	TRRAP MET NRK ATM	1.03e-03	96	136	4	C1319315
Disease	DNA repair protein RAD51 homolog 4 measurement	CYP3A7 CYP3A4	1.13e-03	11	136	2	EFO_0801531
Disease	androstenediol (3beta,17beta) monosulfate (2) measurement	CYP3A7 CYP3A4	1.13e-03	11	136	2	EFO_0800295
Disease	Osteosarcoma	CYP3A4 MET KCNH1	1.34e-03	47	136	3	C0029463
Disease	response to diuretic, high density lipoprotein cholesterol measurement	RABGAP1 TRIP11	1.35e-03	12	136	2	EFO_0004612, GO_0036270
Disease	5alpha-androstan-3beta,17beta-diol monosulfate (2) measurement	CYP3A7 CYP3A4	1.35e-03	12	136	2	EFO_0800291
Disease	androstenediol (3alpha, 17alpha) monosulfate (3) measurement	CYP3A7 CYP3A4	1.59e-03	13	136	2	EFO_0800293
Disease	5alpha-pregnan-3beta,20beta-diol monosulfate (1) measurement	CYP3A7 CYP3A4	1.59e-03	13	136	2	EFO_0800284
Disease	X-21470 measurement	CYP3A7 CYP3A4	1.85e-03	14	136	2	EFO_0800817
Disease	5alpha-androstan-3alpha,17alpha-diol monosulfate measurement	CYP3A7 CYP3A4	1.85e-03	14	136	2	EFO_0800283
Disease	16a-hydroxy DHEA 3-sulfate measurement	CYP3A7 CYP3A4	2.13e-03	15	136	2	EFO_0800301
Disease	X-21410 measurement	CYP3A7 CYP3A4	2.43e-03	16	136	2	EFO_0800813
Disease	andro steroid monosulfate C19H28O6S (1) measurement	CYP3A7 CYP3A4	2.43e-03	16	136	2	EFO_0800305
Disease	Liver carcinoma	KIF23 MCM2 MCM10 MET IGF2BP1 NR1H2 ATM DNASE1L3	2.49e-03	507	136	8	C2239176
Disease	Squamous cell carcinoma	ERCC5 DOCK8 MET ATM	2.64e-03	124	136	4	C0007137
Disease	Benign neoplasm of stomach	MET ATM	2.74e-03	17	136	2	C0153943
Disease	Neoplasm of uncertain or unknown behavior of stomach	MET ATM	2.74e-03	17	136	2	C0496905
Disease	Carcinoma in situ of stomach	MET ATM	2.74e-03	17	136	2	C0154060
Disease	Post-Traumatic Osteoporosis	GPD2 TLN1 FGA	2.84e-03	61	136	3	C0751406
Disease	Osteoporosis, Senile	GPD2 TLN1 FGA	2.84e-03	61	136	3	C0029459
Disease	Osteoporosis, Age-Related	GPD2 TLN1 FGA	2.84e-03	61	136	3	C0001787
Disease	4-ethylphenylsulfate measurement	ATP8B4 LEF1	3.07e-03	18	136	2	EFO_0021148
Disease	5alpha-androstan-3alpha,17beta-diol monosulfate (1) measurement	CYP3A7 CYP3A4	3.07e-03	18	136	2	EFO_0800288
Disease	Osteoporosis	GPD2 TLN1 FGA	3.11e-03	63	136	3	C0029456
Disease	metabolonic lactone sulfate measurement	CYP3A7 CYP3A4	3.43e-03	19	136	2	EFO_0800659
Disease	etiocholanolone glucuronide measurement	CYP3A7 CYP3A4	3.43e-03	19	136	2	EFO_0800362
Disease	squamous cell carcinoma	CDYL HERC2 DNAH11	3.70e-03	67	136	3	EFO_0000707
Disease	androsterone glucuronide measurement	CYP3A7 CYP3A4	3.79e-03	20	136	2	EFO_0800317
Disease	Stomach Carcinoma	MET ATM	4.18e-03	21	136	2	C0699791
Disease	X-24947 measurement	CYP3A7 CYP3A4	4.59e-03	22	136	2	EFO_0800910
Disease	5alpha-androstan-3beta,17beta-diol disulfate measurement	CYP3A7 CYP3A4	4.59e-03	22	136	2	EFO_0021115
Disease	e-selectin measurement	OBP2B EVI5	4.59e-03	22	136	2	EFO_0004575

Protein segments in the cluster

Peptide	Gene	Start	Entry
ETRKLMEECKRLQGE	VAPA	171	Q9P0L0
IMDINKSCKNEERRE	BEND5	401	Q7L4P6
QARKVLMDCQAKAEE	CCDC185	431	Q8N715
ECKSKEEVMAVRLRE	EVI5L	636	Q96CN4
EEAMKIRKQCALVAL	PFKFB2	96	O60825
QKDVCIVLAKEMIRS	CHMP3	56	Q9Y3E7
KIMREKAKERCSEQV	CMC1	21	Q7Z7K0
LKCIELDERLKAMDQ	COPS3	381	Q9UNS2
RCAVTEEHMRKKQQE	RBBP8	91	Q99708
QEERKDAVALCSMAK	ACAD8	341	Q9UKU7
EEMRKVVCDQKLRPN	ACVR1B	441	P36896
VQRMLEVAEKLKCLD	GZF1	106	Q9H116
LAECRANREKMKGEL	ARMC1	66	Q9NVT9
IDKKDCDLFQRRMLE	DNAH11	2751	Q96DT5
LVLKEMADLEKRCER	COMMD5	206	Q9GZQ3
MFCSEKKLREVERIV	ATP8B4	1	Q8TF62
ERMDQCEKEKAGRKI	CCDC144CP	921	Q8IYA2
RHKMDKEINNRTCEV	ATP8B1	166	O43520
MADKRKLQGEIDRCL	CNOT3	1	O75175
LCKRMIETAQVDERA	RAB21	176	Q9UL25
KENREKRMIKRACEQ	RBM43	301	Q6ZSC3
KQTFERLVDIICDKM	RAB3C	181	Q96E17
EETRRQKELLCKMER	RAB11FIP3	521	O75154
LDMARVCSKREKRVA	ITPR3	1446	Q14573
IMVLFATRCNREKKD	PCDH18	716	Q9HCL0
KEMRANVVAECTLKE	LEF1	311	Q9UJU2
KERISDMCKENRESL	MCM2	216	P49736
VTLECVEKLIRKDMV	NOSIP	246	Q9Y314
AEEREMIQKECAAIR	AP1G1	21	O43747
KSKTRELECMRALEE	CDRT4	46	Q8N9R6
QLKEMCRRELDKAES	RABGAP1	911	Q9Y3P9
RDPECQRTEMIKKEE	LEO1	526	Q8WVC0
SVRKMDDKDAAAICQ	GPD2	296	P43304
MRQREELEDKVAACQ	LZTS3	411	O60299
DVATVCRQLAEKRML	MAT2B	226	Q9NZL9
IRRCLKKAIEITECM	MTMR12	366	Q9C0I1
KTERARDMKCLVEKL	HERC2	2086	O95714
TMCKAKLEREAERKN	SPINK5	741	Q9NQ38
VAKLRDEIMALRNEC	DST	466	Q03001
CCRAEQEIMKKVREA	IGF2BP1	336	Q9NZI8
VIAKIQEICERKMAR	AQP7P3	21	A6NL99
DLSEKEKAIVREMCN	CCDC85C	376	A6NKD9
MRLERVCKKDVEING	CYP3A4	371	P08684
EEECSRQMQTEKKRL	MYH14	951	Q7Z406
VRDRCKKEFTDLMTE	PLXNB1	1536	O43157
LEMNEAKVKETLRRC	KSR1	136	Q8IVT5
MKAFCRRELELKEAA	LRRC36	581	Q1X8D7
KRDILNTVADRCEML	ODR4	306	Q5SWX8
MDAKARADCIKEIDL	NEK7	71	Q8TDX7
CKNKEEVMAVRLREA	EVI5	641	O60447
DNEEAMKVRKQCALA	PFKFB3	91	Q16875
KDMRADICVHLNRKV	KCNH1	561	O95259
MELKTKARELREECR	L1RE1	91	Q9UN81
EERMATEKRQLECQR	MYCLP1	331	P12525
RAKEEEMKRFCKAQT	MICAL1	916	Q8TDZ2
KERMGEQEKTQEERC	GOLGA6L7	531	A0A1B0GV03
ELMKELFDQCENKRR	GGA3	246	Q9NZ52
CERDIRRLMDEIKGK	JAKMIP1	201	Q96N16
MEEKMRNIREVKCRV	MCM10	766	Q7L590
EDRCIQKKILMRKTE	OBP2A	71	Q9NY56
EECKDLIKFMLRNER	NBPF1	61	Q3BBV0
DLMNCVQERAKIEKA	PACSIN1	41	Q9BY11
VDMDICRRIDITAKL	IFFO1	326	Q0D2I5
LSDKECAVRRVKTQM	MAP3K13	906	O43283
MRKAIEIDEQQGCKE	FGFR1OP2	186	Q9NVK5
VDMVDCLRQKSAKEL	NLGN3	346	Q9NZ94
EDRCIQKKILMRKTE	OBP2B	71	Q9NPH6
LEKEARRQLVDEVMC	CFAP53	381	Q96M91
EMIKIRSCAERETKK	FRG1	176	Q14331
EEKNRAIIQEVCFMK	GAK	76	O14976
RVKEVEEMCKRSLES	ATM	2151	Q13315
REVAESCKDIKFNEM	IDH3A	216	P50213
AMDVIVKVIKRCDII	DNASE1L3	41	Q13609
IMRCGEAVEKNKRLI	DOCK8	2021	Q8NF50
EIVKCENATVMDKAR	CARD17	41	Q5XLA6
QMEVCRLKKEEEDRI	CEP70	176	Q8NHQ1
VVLEESKALVRCNMK	CDYL	546	Q9Y232
ERCKERVNALAIAVM	DHH	101	O43323
EMVKKSERVLRENQC	CDO1	116	Q16878
VINRDTKRCLEMKKD	GALNT8	591	Q9NY28
MEKVLGRLKDEEIRC	CUL2	236	Q13617
EIKRAEDLCRLMKEK	LUZP1	81	Q86V48
MKRLEVDIDIKIRSC	FGA	166	P02671
CRKLILCADNRKEME	DGKD	121	Q16760
ASAEKAARQMRKCEQ	IP6K1	236	Q92551
MAMVIKDDRLNKDRC	HDDC2	56	Q7Z4H3
VLLKRCVMDDDNEVR	COPG1	511	Q9Y678
RAVLGEVKLCEKMAQ	EEF1G	201	P26641
KRKREDDKLVVECVM	FABP4	106	P15090
EEDRRKMQDKCREVL	HSPA6	566	P17066
RENIVDVKDVMGLKC	CCDC168	3796	Q8NDH2
EEQDIVMKKQVIRRC	CCDC168	5826	Q8NDH2
MRLERVCKKDVEING	CYP3A7	371	P24462
ERMDQCEKEKAGRKI	CCDC144A	1111	A2RUR9
EVVIKQMKECNATRR	METTL13	81	Q8N6R0
RAVKERMDRQCAQVK	CAVIN2	126	O95810
LQFKMDACSTEERKR	SCGN	186	O76038
RQKEEALVQREKMCL	CDC37L1	111	Q7L3B6
EMIDTARNKARVKAC	FAM162B	96	Q5T6X4
QREEQCREMERLIKK	PDCL	76	Q13371
RVCFEMKINEEISVK	HNRNPUL1	256	Q9BUJ2
EKECERRVAAKQLEM	KIF23	626	Q02241
SKRRQEEMLKTEEAC	NRK	1291	Q7Z2Y5
AARNCMLDEKFTVKV	MET	1206	P08581
KCLEEMKREARTIKI	SNX13	76	Q9Y5W8
EQRMLDCKRVLDGVK	UTRN	1441	P46939
EIEMEAERVAKRKCP	TRIM44	166	Q96DX7
MKKRVEDAFILICNV	CCT6B	221	Q92526
ERDVVIRLMNKCEDI	SMARCAD1	451	Q9H4L7
KMESICQARAKELED	SYNE2	1926	Q8WXH0
EECKDLIKFMLRNER	NBPF9	61	P0DPF3
EECKDLIKFMLRNER	NBPF10	61	Q6P3W6
EECKDLIKFMLRNER	NBPF11	61	Q86T75
EECKDLIKFMLRNER	NBPF12	61	Q5TAG4
EECKDLIKFMLRNER	NBPF15	61	Q8N660
EECKDLIKFMLRNER	NBPF19	61	A0A087WUL8
LRKCKEAGMREQCVL	NR1H2	146	P55055
NRAVTCMLRKEKEAA	ERCC5	1016	P28715
CMLRKEKEAAASEIE	ERCC5	1021	P28715
RRMEEQRKAACAEKL	PRRC2C	471	Q9Y520
MAEREIVRDIKEKLC	POTEJ	866	P0CG39
VMRKAVQVDDDQFCK	SIKE1	151	Q9BRV8
KMCKRNEFESVLALV	NCKIPSD	431	Q9NZQ3
ELKRCVCERRAGMVK	CLEC1A	251	Q8NC01
CEECQKAKDRMERIT	URGCP	466	Q8TCY9
EESIMNIIRKEVEKC	TUBD1	116	Q9UJT1
MVLRRAAQEKDKGVC	LINC00173	41	Q6ZV60
LRLRKDCESVNEGKM	ZNF99	111	A8MXY4
LLEDAIEVCKKFMER	UCHL3	201	P15374
QQMLRRKVVDCSREE	SLC7A1	11	P30825
CVMRVDEKTKEVIQE	TLN1	336	Q9Y490
RKDILKDLVEMCRGV	VPS35	126	Q96QK1
MIEVVCNDRLGKKVR	UBL5	1	Q9BZL1
DAMRDLAQCVNEVKR	VAV1	361	P15498
VAKDMAAAAVRCIRK	RTCA	206	O00442
MECAEKQGQIERVIK	SCLT1	406	Q96NL6
QEACMRKEKSVAVLE	TRIM72	141	Q6ZMU5
CRKDVEMEPVQQAEK	ROCK1	1206	Q13464
KMENEKLVLACEDVR	TRIP11	676	Q15643
VACKVKADQDSEAMR	TLN2	2441	Q9Y4G6
AAEECRVQKLIKEMD	TRIM64C	131	A6NLI5
RREIEAIQCEVRKMC	SETBP1	1401	Q9Y6X0
RVANCQTVRMKEEKE	TRRAP	616	Q9Y4A5
AEACDIMVKRGDKKR	UFL1	646	O94874
SLDICRKMEKEAAVA	ZBTB8B	121	Q8NAP8
RFQDEKNKEVVLMCI	SLC16A10	321	Q8TF71
ETQRTFLKEVKVMRC	LIMK1	376	P53667