Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyBiologicalProcessrenal water homeostasis

ATP6V1B1 AQP7P3 AKAP11 NFAT5

1.08e-05261114GO:0003091
GeneOntologyBiologicalProcessrenal system process

ATP6V1B1 SCN11A AQP7P3 OIT3 AKAP11 NFAT5 TRPV5

1.62e-051491117GO:0003014
GeneOntologyBiologicalProcessmulticellular organismal-level water homeostasis

ATP6V1B1 AQP7P3 AKAP11 NFAT5

3.66e-05351114GO:0050891
GeneOntologyBiologicalProcessregulation of transcription initiation by RNA polymerase II

HNF1B CTNNBIP1 ZNF451 TAF2 ZNHIT1

7.63e-05811115GO:0060260
DomainLRRC37AB_C

LRRC37A3 LRRC37A2 LRRC37A

8.14e-0741113IPR029423
DomainLRRC37AB_C

LRRC37A3 LRRC37A2 LRRC37A

8.14e-0741113PF14914
DomainLRRC37_N

LRRC37A3 LRRC37A2 LRRC37A

8.14e-0741113IPR032754
DomainLRRC37

LRRC37A3 LRRC37A2 LRRC37A

8.14e-0741113PF15779
DomainLRRC37A/B-like

LRRC37A3 LRRC37A2 LRRC37A

8.14e-0741113IPR015753
DomainLRR_8

LRRC8E PODNL1 LRRC37A3 MFHAS1 LRRC37A2 LRRC10 LRRC37A PODN LRRN2

8.32e-071711119PF13855
DomainLRR_TYP

LRRC8E PODNL1 LRRC37A3 MFHAS1 LRRC37A2 LRRC10 LRRC37A PODN LRRN2

1.11e-061771119SM00369
DomainLeu-rich_rpt_typical-subtyp

LRRC8E PODNL1 LRRC37A3 MFHAS1 LRRC37A2 LRRC10 LRRC37A PODN LRRN2

1.11e-061771119IPR003591
DomainLRR

LRRC8E PODNL1 LRRC37A3 MFHAS1 LRRC37A2 LRRC10 LRRC37A PODN LRRN2

3.17e-062011119PS51450
DomainLRR_1

LRRC8E PODNL1 LRRC37A3 MFHAS1 LRRC37A2 LRRC10 LRRC37A PODN LRRN2

6.38e-062191119PF00560
DomainARM-type_fold

MON2 IPO5 UBR4 NBEA PPP4R4 ITPR2 PIK3CA TAF2 STAG3 XPOT

3.46e-0533911110IPR016024
DomainLeu-rich_rpt

LRRC8E PODNL1 LRRC37A3 MFHAS1 LRRC37A2 LRRC10 LRRC37A PODN LRRN2

3.47e-052711119IPR001611
DomainTRPV5/TRPV6

TRPV6 TRPV5

3.50e-0521112IPR008344
Domain-

LRRC8E PODNL1 LRRC37A3 MFHAS1 LRRC37A2 LRRC10 LRRC37A PODN LRRN2

1.27e-0432111193.80.10.10
DomainL_dom-like

LRRC8E PODNL1 LRRC37A3 MFHAS1 LRRC37A2 LRRC10 LRRC37A PODN LRRN2

1.50e-043281119IPR032675
Domainp53-like_TF_DNA-bd

TBX4 RUNX2 MGA NFAT5

2.76e-04531114IPR008967
DomainCA

PCDHA1 FREM2 PCDH19 DCHS1 PCDHGA8

6.18e-041151115SM00112
DomainCadherin

PCDHA1 FREM2 PCDH19 DCHS1 PCDHGA8

6.95e-041181115IPR002126
DomainBROMODOMAIN_1

BAZ2B TRIM66 TAF1L

1.37e-03371113PS00633
DomainBromodomain

BAZ2B TRIM66 TAF1L

1.48e-03381113PF00439
DomainBROMODOMAIN_2

BAZ2B TRIM66 TAF1L

1.85e-03411113PS50014
DomainTRP_channel

TRPV6 TRPV5

1.86e-03111112IPR004729
DomainBromodomain

BAZ2B TRIM66 TAF1L

1.98e-03421113IPR001487
DomainBROMO

BAZ2B TRIM66 TAF1L

1.98e-03421113SM00297
Domain-

BAZ2B TRIM66 TAF1L

1.98e-034211131.20.920.10
DomainBbox_C

TRIM66 TRIM37

3.49e-03151112IPR003649
DomainBBC

TRIM66 TRIM37

3.49e-03151112SM00502
DomainCadherin_CS

PCDHA1 PCDH19 DCHS1 PCDHGA8

4.07e-031091114IPR020894
DomainTF_T-box

TBX4 MGA

4.49e-03171112IPR001699
DomainImportin-beta_N

IPO5 XPOT

4.49e-03171112IPR001494
DomainTBOX

TBX4 MGA

4.49e-03171112SM00425
DomainTF_T-box_CS

TBX4 MGA

4.49e-03171112IPR018186
Domain-

TBX4 MGA

4.49e-031711122.60.40.820
DomainTBOX_3

TBX4 MGA

4.49e-03171112PS50252
DomainT-box

TBX4 MGA

4.49e-03171112PF00907
DomainTBOX_1

TBX4 MGA

4.49e-03171112PS01283
DomainTBOX_2

TBX4 MGA

4.49e-03171112PS01264
DomainCADHERIN_1

PCDHA1 PCDH19 DCHS1 PCDHGA8

4.63e-031131114PS00232
DomainCadherin

PCDHA1 PCDH19 DCHS1 PCDHGA8

4.63e-031131114PF00028
DomainIon_trans_dom

SCN11A ITPR2 TRPV6 TRPV5

4.78e-031141114IPR005821
DomainIon_trans

SCN11A ITPR2 TRPV6 TRPV5

4.78e-031141114PF00520
DomainCADHERIN_2

PCDHA1 PCDH19 DCHS1 PCDHGA8

4.78e-031141114PS50268
Domain-

PCDHA1 PCDH19 DCHS1 PCDHGA8

4.78e-0311411142.60.40.60
DomainCadherin-like

PCDHA1 PCDH19 DCHS1 PCDHGA8

5.08e-031161114IPR015919
DomainARM-like

MON2 IPO5 NBEA PPP4R4 STAG3 XPOT

5.52e-032701116IPR011989
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

ARHGAP32 BAZ2B GNPTAB CC2D1B ALPK1 USP20 PPP4R4 FAN1 TRIM66 TSC22D1 LARP4B NPHP3 CNTNAP4 CGNL1 MGA

1.13e-104931161515368895
Pubmed

Primate segmental duplication creates novel promoters for the LRRC37 gene family within the 17q21.31 inversion polymorphism region.

LRRC37A3 LRRC37A2 LRRC37A

1.44e-074116322419166
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

ARHGAP32 KDM5A BCAS3 ATG13 ALPK1 PPP4R4 C6orf132 NHSL1 MAP7D1 CLMN COBL AKAP11 CGNL1 PLK4 CNOT4

1.93e-078611161536931259
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

MON2 LRRC8E MFHAS1 BCAS3 BICRA UBR4 TEP1 PLXNB2 C6orf132 ITPR2 NHSL1 PLA2G4B RALGPS1 LRP5 COBL

4.25e-0611051161535748872
Pubmed

Evolutionary dynamism of the primate LRRC37 gene family.

LRRC37A3 LRRC37A2 LRRC37A

4.26e-0610116323064749
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

IPO5 KDM5A GNPTAB UBR4 CHD9 NBEA FAN1 TRIM66 ZNF451 SERGEF YLPM1 RNF216 LRRN2 ZNHIT1 TRIM37 XPOT

5.92e-0612851161635914814
Pubmed

Alteration of calcium homeostasis in primary preeclamptic syncytiotrophoblasts: effect on calcium exchange in placenta.

TRPV6 TRPV5

1.10e-052116220178461
Pubmed

The TRPV5/6 calcium channels contain multiple calmodulin binding sites with differential binding properties.

TRPV6 TRPV5

1.10e-052116222354706
Pubmed

Diverse calcium channel types are present in the human placental syncytiotrophoblast basal membrane.

TRPV6 TRPV5

1.10e-052116216564089
Pubmed

Endogenous expression of TRPV5 and TRPV6 calcium channels in human leukemia K562 cells.

TRPV6 TRPV5

1.10e-052116219295174
Pubmed

Human TRPV5 and TRPV6: key players in cadmium and zinc toxicity.

TRPV6 TRPV5

1.10e-052116223968883
Pubmed

Functional relevance of the BMD-associated polymorphism rs312009: novel involvement of RUNX2 in LRP5 transcriptional regulation.

RUNX2 LRP5

1.10e-052116221542013
Pubmed

Expression of calcium channels along the differentiation of cultured trophoblast cells from human term placenta.

TRPV6 TRPV5

1.10e-052116212390878
Pubmed

Homo- and heterotetrameric architecture of the epithelial Ca2+ channels TRPV5 and TRPV6.

TRPV6 TRPV5

1.10e-052116212574114
Pubmed

Structural conservation of the genes encoding CaT1, CaT2, and related cation channels.

TRPV6 TRPV5

1.10e-052116211549322
Pubmed

[TRPV5 and TRPV6 calcium channels in human T cells].

TRPV6 TRPV5

1.10e-052116219140341
Pubmed

TRPV5 and TRPV6 are expressed in placenta and bone tissues during pregnancy in mice.

TRPV6 TRPV5

1.10e-052116230916584
Pubmed

Mouse mutants in schizophrenia risk genes GRIN2A and AKAP11 show EEG abnormalities in common with schizophrenia patients.

GRIN2A AKAP11

1.10e-052116236914641
Pubmed

The calcium-sensing receptor promotes urinary acidification to prevent nephrolithiasis.

ATP6V1B1 TRPV5

1.10e-052116219470676
Pubmed

Interaction of the epithelial Ca2+ channels TRPV5 and TRPV6 with the intestine- and kidney-enriched PDZ protein NHERF4.

TRPV6 TRPV5

1.10e-052116216565876
Pubmed

Age-dependent alterations in Ca2+ homeostasis: role of TRPV5 and TRPV6.

TRPV6 TRPV5

1.10e-052116216705151
Pubmed

Expression of transient receptor potential vanilloid channels TRPV5 and TRPV6 in retinal pigment epithelium.

TRPV6 TRPV5

1.10e-052116220405023
Pubmed

TRIM37 controls cancer-specific vulnerability to PLK4 inhibition.

PLK4 TRIM37

1.10e-052116232908304
Pubmed

A single amino acid mutation results in a rapid inactivation of epithelial calcium channels.

TRPV6 TRPV5

1.10e-052116211846401
Pubmed

First evidence of TRPV5 and TRPV6 channels in human parathyroid glands: possible involvement in neoplastic transformation.

TRPV6 TRPV5

1.10e-052116225164318
Pubmed

Expression and prognostic roles of TRPV5 and TRPV6 in non-small cell lung cancer after curative resection.

TRPV6 TRPV5

1.10e-052116224761864
Pubmed

Reduced Immunohistochemical Expression of Hnf1β and FoxA2 in Liver Tissue Can Discriminate Between Biliary Atresia and Other Causes of Neonatal Cholestasis.

HNF1B FOXA2

1.10e-052116229406331
Pubmed

Regulation of the mouse epithelial Ca2(+) channel TRPV6 by the Ca(2+)-sensor calmodulin.

TRPV6 TRPV5

1.10e-052116215123711
Pubmed

Fast and slow inactivation kinetics of the Ca2+ channels ECaC1 and ECaC2 (TRPV5 and TRPV6). Role of the intracellular loop located between transmembrane segments 2 and 3.

TRPV6 TRPV5

1.10e-052116212077127
Pubmed

Single-channel activities of the human epithelial Ca2+ transport proteins CaT1 and CaT2.

TRPV6 TRPV5

1.10e-052116211719848
Pubmed

Concerted action of associated proteins in the regulation of TRPV5 and TRPV6.

TRPV6 TRPV5

1.10e-052116217233615
Pubmed

[The functional characteristics oF TRPV5 and TRPV6 channels in normal and transformed human blood lymphocytes].

TRPV6 TRPV5

1.10e-052116224592736
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: I. The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

UBR4 CHD9 NBEA PLXNB2 TRIM37

1.12e-0587116512465718
Pubmed

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.

MON2 KDM5A BICRA HNRNPM CHD9 TEP1 BOD1L2 TRIM66 LARP4B MAP7D1 PRPF3 PCDH19 TAF2 MGA

2.19e-0511161161431753913
Pubmed

Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

CHD9 PLXNB2 TRIM66 RALGPS1 PCDHGA8

2.67e-0510411659205841
Pubmed

A molecular determinant of phosphoinositide affinity in mammalian TRPV channels.

TRPV6 TRPV5

3.30e-053116227291418
Pubmed

The deubiquitinating enzyme USP20 stabilizes ULK1 and promotes autophagy initiation.

ATG13 USP20

3.30e-053116229487085
Pubmed

Calbindin-D28K dynamically controls TRPV5-mediated Ca2+ transport.

TRPV6 TRPV5

3.30e-053116216763551
Pubmed

Direct interaction with Rab11a targets the epithelial Ca2+ channels TRPV5 and TRPV6 to the plasma membrane.

TRPV6 TRPV5

3.30e-053116216354700
Pubmed

Clinicopathologic Significance of HNF-1β, AIRD1A, and PIK3CA Expression in Ovarian Clear Cell Carcinoma: A Tissue Microarray Study of 130 Cases.

HNF1B PIK3CA

3.30e-053116226945423
Pubmed

Lack of pendrin HCO3- transport elevates vestibular endolymphatic [Ca2+] by inhibition of acid-sensitive TRPV5 and TRPV6 channels.

TRPV6 TRPV5

3.30e-053116217200157
Pubmed

Age-dependent changes in the expression of klotho protein, TRPV5 and TRPV6 in mouse inner ear.

TRPV6 TRPV5

3.30e-053116219922080
Pubmed

Identification of BSPRY as a novel auxiliary protein inhibiting TRPV5 activity.

TRPV6 TRPV5

3.30e-053116216380433
Pubmed

Knockdown of CEACAM19 suppresses human gastric cancer through inhibition of PI3K/Akt and NF-κB.

CEACAM19 PIK3CA

3.30e-053116230217308
Pubmed

Inferring nonneutral evolution from human-chimp-mouse orthologous gene trios.

TACO1 RUNX2 TEP1

3.37e-0519116314671302
Pubmed

The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells.

IPO5 BAZ2B UBR4 CHD9 TUT1 AKAP11 TAF2

4.70e-05282116723667531
Pubmed

Functional expression of the epithelial Ca(2+) channels (TRPV5 and TRPV6) requires association of the S100A10-annexin 2 complex.

TRPV6 TRPV5

6.59e-054116212660155
Pubmed

Genetic variation within adrenergic pathways determines in vivo effects of presynaptic stimulation in humans.

ATP6V1B1 CHGB

6.59e-054116218180394
Pubmed

The role of Lrp5/6 in cardiac valve disease: experimental hypercholesterolemia in the ApoE-/- /Lrp5-/- mice.

RUNX2 LRP5

6.59e-054116221678468
Pubmed

The mouse homeobox gene Not is required for caudal notochord development and affected by the truncate mutation.

FOXA2 COBL

6.59e-054116215231714
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

MON2 ATG13 IGDCC4 MAP7D1 ZNF451 PCDH19 COBL NFAT5

6.94e-05407116812693553
Pubmed

Human transcription factor protein interaction networks.

ARHGAP32 HNF1B KDM5A BICRA UBR4 LARP4B MAP7D1 ZNF451 YLPM1 TAF2 ZNHIT1 MGA TAF1L CCDC86 XPOT

8.37e-0514291161535140242
Pubmed

Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.

ARHGAP32 BICRA UBR4 HNRNPM C6orf132 LARP4B YLPM1 MGA

1.02e-04430116835044719
Pubmed

Calcium transport genes are differently regulated in maternal and fetal placenta in the knockout mice of calbindin-D(9k) and -D(28k).

TRPV6 TRPV5

1.10e-045116222407925
Pubmed

Role and regulation of TRP channels in neutrophil granulocytes.

TRPV6 TRPV5

1.10e-045116212765698
Pubmed

Screen identifies bromodomain protein ZMYND8 in chromatin recognition of transcription-associated DNA damage that promotes homologous recombination.

KDM5A BAZ2B HNRNPM TRIM66

1.19e-0475116425593309
Pubmed

Essential roles for the splicing regulator nSR100/SRRM4 during nervous system development.

MON2 NBEA TAF1L

1.52e-0431116325838543
Pubmed

Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia.

IPO5 GNPTAB NBEA ZNF451 KIF3C

1.57e-04151116517043677
Pubmed

Transforming growth factor-beta regulates basal transcriptional regulatory machinery to control cell proliferation and differentiation in cranial neural crest-derived osteoprogenitor cells.

RUNX2 TAF1L

1.64e-046116219959467
Pubmed

Image-based genome-wide siRNA screen identifies selective autophagy factors.

ATG13 ALPK1 RFWD3 DZANK1 PIK3CA

2.00e-04159116522020285
Pubmed

Wnt9a deficiency discloses a repressive role of Tcf7l2 on endocrine differentiation in the embryonic pancreas.

HNF1B CHGB FOXA2

2.01e-0434116326771085
Pubmed

Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.

MON2 ARHGAP32 NBEA PPP4R4 FAN1 ITPR2 NHSL1 PRPF3 YLPM1 CCDC86 PLK4 XPOT

2.06e-0410491161227880917
Pubmed

Fine mapping and association studies of a high-density lipoprotein cholesterol linkage region on chromosome 16 in French-Canadian subjects.

NUDT7 RFWD3 CNTNAP4

2.19e-0435116319844255
Pubmed

Embryonic ablation of osteoblast Smad4 interrupts matrix synthesis in response to canonical Wnt signaling and causes an osteogenesis-imperfecta-like phenotype.

RUNX2 LRP5

2.29e-047116224006258
Pubmed

Schnurri-3 regulates ERK downstream of WNT signaling in osteoblasts.

RUNX2 LRP5

2.29e-047116223945236
Pubmed

A human MAP kinase interactome.

ARHGAP32 BICRA HNRNPM TSC22D1 ZNF451 COBL CGNL1 MGA

2.34e-04486116820936779
Pubmed

Maternal Transient Receptor Potential Vanilloid 6 (Trpv6) Is Involved In Offspring Bone Development.

ITPR2 TRPV6 TRPV5

2.80e-0438116330786075
Pubmed

Genome-wide association study of d-amphetamine response in healthy volunteers identifies putative associations, including cadherin 13 (CDH13).

ANKRD31 LRRC37A CNTNAP4

2.80e-0438116322952603
Pubmed

Cooperation of TLR2 with MyD88, PI3K, and Rac1 in lipoteichoic acid-induced cPLA2/COX-2-dependent airway inflammatory responses.

PIK3CA PLA2G4B

3.05e-048116220167866
Pubmed

Cyclin M2 (CNNM2) knockout mice show mild hypomagnesaemia and developmental defects.

TRPV6 TRPV5

3.05e-048116233859252
Pubmed

Systematic proteomics of endogenous human cohesin reveals an interaction with diverse splicing factors and RNA-binding proteins required for mitotic progression.

KDM5A BICRA UBR4 HNRNPM MGA STAG3

3.13e-04272116631010829
Pubmed

The variant Polycomb Repressor Complex 1 component PCGF1 interacts with a pluripotency sub-network that includes DPPA4, a regulator of embryogenesis.

ATG13 UBR4 CDAN1 MAP7D1 PRPF3 ANGEL2 CCDC86

3.79e-04396116726687479
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

ARHGAP32 KDM5A UBR4 HNRNPM NBEA GRIN2A DZANK1 MAP7D1 YLPM1 DCHS1 MGA

3.88e-049631161128671696
Pubmed

Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

ATG13 HEPH COBL AKAP11

3.88e-0410211649734811
Pubmed

Deubiquitinase OTUD3 regulates metabolism homeostasis in response to nutritional stresses.

HNF1B FOXA2

3.91e-049116235675826
Pubmed

Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

LRRC37A3 LRRC37A ZNF451 MGA

4.33e-0410511649628581
Pubmed

Quantitative gene expression profiling reveals a fetal hepatic phenotype of murine ES-derived hepatocytes.

HNF1B FOXA2

4.88e-0410116215005571
Pubmed

All-trans retinoic acid-induced ectopic limb and caudal structures: murine strain sensitivities and pathogenesis.

TBX4 FOXA2

4.88e-0410116218498097
Pubmed

Exportin 4: a mediator of a novel nuclear export pathway in higher eukaryotes.

IPO5 XPOT

4.88e-0410116210944119
Pubmed

The onecut transcription factor HNF6 is required for normal development of the biliary tract.

HNF1B FOXA2

4.88e-0410116211934848
Pubmed

Lrp5 and Lrp6 redundantly control skeletal development in the mouse embryo.

RUNX2 LRP5

4.88e-0410116221924256
Pubmed

Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies.

TRIM66 NPHP3 NFAT5

4.94e-0446116321102462
Pubmed

Recruitment of the Mammalian Histone-modifying EMSY Complex to Target Genes Is Regulated by ZNF131.

KDM5A HNRNPM CHD9 PRPF3

5.17e-04110116426841866
Pubmed

Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis.

PODNL1 UBR4 TUT1 NHSL1 CLMN ZNF451 TAF2 MGA TAF1L

5.18e-04689116936543142
Pubmed

Dchs1-Fat4 regulation of osteogenic differentiation in mouse.

RUNX2 DCHS1

5.95e-0411116231358536
Pubmed

Plasticity and expanding complexity of the hepatic transcription factor network during liver development.

HNF1B FOXA2

5.95e-0411116216912278
Pubmed

Tissue-specific calibration of extracellular matrix material properties by transforming growth factor-β and Runx2 in bone is required for hearing.

RUNX2 LRP5

5.95e-0411116220847738
Pubmed

RICS, a novel GTPase-activating protein for Cdc42 and Rac1, is involved in the beta-catenin-N-cadherin and N-methyl-D-aspartate receptor signaling.

ARHGAP32 GRIN2A

5.95e-0411116212531901
Pubmed

Toward simpler and faster genome-wide mutagenesis in mice.

PCDHA1 RUNX2

5.95e-0411116217572674
Pubmed

Expression patterns of vHNF1 and HNF1 homeoproteins in early postimplantation embryos suggest distinct and sequential developmental roles.

HNF1B FOXA2

5.95e-041111621363228
Pubmed

Essential role of the TFIID subunit TAF4 in murine embryogenesis and embryonic stem cell differentiation.

FOXA2 TAF2 TAF1L

6.32e-0450116327026076
Pubmed

Association of granulomatosis with polyangiitis (Wegener's) with HLA-DPB1*04 and SEMA6A gene variants: evidence from genome-wide analysis.

COBL CCDC86

7.12e-0412116223740775
Pubmed

Rab23 is an essential negative regulator of the mouse Sonic hedgehog signalling pathway.

FOXA2 ZNF451

7.12e-0412116211449277
Pubmed

A hypomorphic mutation in Pold1 disrupts the coordination of embryo size expansion and morphogenesis during gastrulation.

TBX4 FOXA2

7.12e-0412116235876795
Pubmed

Sox9-haploinsufficiency causes glucose intolerance in mice.

HNF1B FOXA2

7.12e-0412116221829703
Pubmed

The TIP60 Complex Is a Conserved Coactivator of HIF1A.

MON2 IPO5 HNRNPM XPOT

7.16e-04120116427320910
Pubmed

Cytoplasmic Metadherin (MTDH) provides survival advantage under conditions of stress by acting as RNA-binding protein.

BCAS3 TBC1D2B TEP1 CLMN LRP5

7.76e-04214116522199357
Pubmed

An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.

MON2 ITPR2 LARP4B CTNNBIP1 CLMN ZNF451 YLPM1 TMEM131L MGA

8.04e-04733116934672954
Pubmed

Neurogenin3 cooperates with Foxa2 to autoactivate its own expression.

HNF1B FOXA2

8.40e-0413116223471965
Pubmed

Hepatocyte nuclear factor 3beta (Foxa2) is dispensable for maintaining the differentiated state of the adult hepatocyte.

HNF1B FOXA2

8.40e-0413116210866673
Cytoband16q23.1

NUDT7 RFWD3 CNTNAP4

7.77e-0532118316q23.1
Cytoband12p11

KDM5A ITPR2

2.33e-049118212p11
ToppCellCOVID-19-kidney-CNT|COVID-19 / Disease (COVID-19 only), tissue and cell type

HNF1B MFHAS1 FREM2 CLMN LRRN2 TRPV6 TRPV5

8.17e-071921187760c6b9628de9693034b00c5025c5c4df94bb2e8
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

HNF1B MFHAS1 FREM2 CLMN RALGPS1 COBL CGNL1

8.75e-0719411875eaaa81f4b2535f983c424aaef00077089526a5c
ToppCellTracheal-NucSeq|Tracheal / Cell types per location group and 10X technology with lineage, and cell group designations

MON2 ARHGAP32 LRRC37A3 BAZ2B BCAS3 NBEA ITPR2

1.04e-06199118794b94b17ca18b8dc27b91da1f2ccf89e03cc7035
ToppCellChildren_(3_yrs)-Mesenchymal-vascular_smooth_muscle_cell-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

ANKRD31 TBX4 ARHGEF39 CLMN PCDH19 DCHS1

4.86e-0616311868f24cef152f5965727bbeee116bd26c75cbba82a
ToppCellnormal_Lymph_Node-B_lymphocytes-GrB-secreting_B_cells|normal_Lymph_Node / Location, Cell class and cell subclass

LRRC37A3 RUNX2 PLXNB2 LRRC37A LRP5 COBL

7.30e-06175118629fbdfe1d3bfcb063be2bced0128a33176c5b78f
ToppCell5'-Airway_Nasal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PODNL1 BCAS3 C6orf132 TRIM66 SLC35E2A COBL

7.54e-06176118687de432c680b80555342afac864599bbc002c040
ToppCelldroplet-Liver-Npc-18m-Endothelial-nan|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MFHAS1 CDAN1 OIT3 MANSC1 DCHS1 TRIM37

1.03e-05186118675258d88e23112fd1f0f7c71ef0366abb400d33e
ToppCellCV-Moderate-7|CV / Virus stimulation, Condition and Cluster

MON2 GNPTAB RUNX2 ITPR2 TMEM131L NFAT5

1.03e-0518611868571956890fc9894d766ba294a28e376b4aba428
ToppCellCOVID-19-kidney-DCT|COVID-19 / Disease (COVID-19 only), tissue and cell type

HNF1B MFHAS1 FREM2 CLMN CGNL1 TRPV5

1.10e-0518811861d56cd409793f05cca20757ab26e91f1a1ee67b5
ToppCellLPS_anti-TNF-Epithelial_alveolar-AT_1-Differentiating_AT2|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

FOXA2 PLXNB2 PLA2G4B LPIN2 COBL CGNL1

1.43e-0519711863d13a4f2e86422900ee2194e8a1fd1cf9750d5d3
ToppCellTracheal-NucSeq-Epithelial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ARHGAP32 NBEA CLMN LRP5 COBL CGNL1

1.56e-052001186d3af0a706baf66e3f32e67b17dcfc31e5b32ce0e
ComputationalNeighborhood of RAN

IPO5 CHD9 FAN1 GORASP1 RALGPS1 SLC35E2A TRIM37

1.55e-04196647GCM_RAN
DrugTiratricol, 3,3',5-triiodothyroacetic acid [51-24-1]; Up 200; 6.4uM; MCF7; HT_HG-U133A

IPO5 TUT1 ALPK1 TEP1 DZANK1 CLMN LRP5 KIF3C CNOT4

7.53e-0719811597011_UP
Drugflurothyl

SCN11A GRIN2A OIT3 TRIM37 GABRA4

3.90e-06471155CID000009528
DrugTerconazole [67915-31-5]; Down 200; 7.6uM; MCF7; HT_HG-U133A

IPO5 ATG13 FAN1 ITPR2 DZANK1 CLMN LPIN2 CNOT4

7.04e-0619611582844_DN
DrugMeprylcaine hydrochloride [956-03-6]; Down 200; 14.8uM; MCF7; HT_HG-U133A

IPO5 ARHGAP32 KDM5A TUT1 ALPK1 LARP4B LRP5 NFAT5

7.31e-0619711583544_DN
DrugMegestrol acetate [595-33-5]; Down 200; 10.4uM; MCF7; HT_HG-U133A

MFHAS1 TUT1 ALPK1 FAN1 TRIM66 DZANK1 CLMN RALGPS1

7.59e-0619811585013_DN
DrugMeclofenoxate hydrochloride [3685-84-5]; Down 200; 13.6uM; MCF7; HT_HG-U133A

KDM5A TEP1 PPP4R4 LARP4B RALGPS1 TRPV6 NFAT5

5.35e-0519111573605_DN
DrugBendroflumethiazide [73-48-3]; Down 200; 9.4uM; PC3; HT_HG-U133A

MON2 KDM5A TUT1 ALPK1 TEP1 ANGEL2 STAG3

5.71e-0519311574315_DN
DrugLY 294002; Up 200; 10uM; PC3; HT_HG-U133A

BAZ2B SOX30 FOXA2 MANSC1 RALGPS1 LPIN2 TRPV6

5.90e-0519411571239_UP
Drugchlorpromazine hydrochloride; Down 200; 1uM; PC3; HT_HG-U133A

ARHGAP32 KDM5A BAZ2B FAN1 ITPR2 RNF216 STAG3

5.90e-0519411571217_DN
Drugamitriptyline hydrochloride; Down 200; 1uM; MCF7; HG-U133A

ATG13 TBC1D2B TRMO ALPK1 YLPM1 COBL KIF3C

6.29e-051961157167_DN
DrugTrifluridine [70-00-8]; Down 200; 13.6uM; PC3; HT_HG-U133A

HNF1B ITPR2 YLPM1 LRP5 COBL RNF216 KIF3C

6.50e-0519711575819_DN
DrugCinchonine [118-10-5]; Up 200; 13.6uM; PC3; HT_HG-U133A

MFHAS1 TBC1D2B CHGB PPP4R4 ITPR2 TRIM66 ANGEL2

6.50e-0519711573988_UP
DrugAG-028671 [847803-03-6]; Down 200; 10uM; PC3; HT_HG-U133A

HNF1B ATG13 TBC1D2B RUNX2 PPP4R4 COBL STAG3

6.71e-0519811576557_DN
DrugTrichlorfon [52-68-6]; Down 200; 15.6uM; PC3; HT_HG-U133A

HNF1B BICRA ALPK1 FOXA2 DZANK1 YLPM1 NFAT5

6.71e-0519811571797_DN
Drugsodium 4-phenylbutyrate; Down 200; 1000uM; MCF7; HG-U133A

BICRA ATG13 TRMO TUT1 GRIN2A LARP4B STAG3

6.71e-051981157407_DN
DrugMethacholine chloride [62-51-1]; Up 200; 20.4uM; MCF7; HT_HG-U133A

MON2 TUT1 RUNX2 TRIM66 DZANK1 LPIN2 TRPV6

6.71e-0519811576248_UP
DrugAmrinone [60719-84-8]; Down 200; 21.4uM; HL60; HT_HG-U133A

MON2 ARHGAP32 PPP4R4 ITPR2 LARP4B RNF216 KIF3C

6.71e-0519811572724_DN
Drug3-nitropropionic acid; Up 200; 10uM; PC3; HT_HG-U133A

BICRA TBC1D2B TEP1 PPP4R4 RALGPS1 COBL STAG3

6.93e-0519911576407_UP
DrugVidarabine [5536-17-4]; Down 200; 15uM; HL60; HT_HG-U133A

PPP4R4 ITPR2 CTNNBIP1 YLPM1 KIF3C CNOT4 GABRA4

6.93e-0519911572706_DN
DrugAmidopyrine [58-15-1]; Down 200; 17.2uM; HL60; HG-U133A

TRMO ALPK1 USP20 RFWD3 TSC22D1 YLPM1 RNF216

7.15e-0520011571376_DN
DrugMonocrotaline [315-22-0]; Up 200; 12.2uM; HL60; HG-U133A

IPO5 BICRA TBC1D2B TRMO USP20 GORASP1 YLPM1

7.15e-0520011571757_UP
Drugbenzothiophene-2-boronic acid

HNF1B RUNX2

7.56e-0531152CID000002359
DiseaseCongenital dyserythropoietic anemia

CDAN1 LPIN2

1.52e-0451162C0002876
Diseaseasthma, endometriosis

MFHAS1 PLXNB2 ITPR2 XPOT

2.11e-04741164EFO_0001065, MONDO_0004979
Diseaselysosomal protective protein measurement

GNPTAB TMEM131L

3.18e-0471162EFO_0008215
Diseaseautism spectrum disorder (implicated_via_orthology)

ARHGAP32 KDM5A CHD9 NBEA CNTNAP4

3.44e-041521165DOID:0060041 (implicated_via_orthology)
Diseaseguanosine diphosphate measurement

BAZ2B NBEA

8.23e-04111162EFO_0010494
Diseasemacula measurement

ARHGAP32 BCAS3 YLPM1 COBL CGNL1

9.23e-041891165EFO_0008375
Diseaseautosomal dominant polycystic kidney disease (implicated_via_orthology)

NPHP3 LRP5

1.35e-03141162DOID:898 (implicated_via_orthology)
DiseaseAbnormality of refraction

ARHGAP32 KDM5A BCAS3 NBEA PCDHA1 GRIN2A ITPR2 GNPDA2 COBL

1.39e-036731169HP_0000539
Diseaseobesity (implicated_via_orthology)

PLXNB2 ITPR2 GORASP1 LPIN2 DCHS1

1.63e-032151165DOID:9970 (implicated_via_orthology)
Diseaseankle injury

CHD9 LARP4B TAF2

1.64e-03591163EFO_1002021
Diseasecreatinine measurement

ATP6V1B1 TBX4 BCAS3 CHD9 PLXNB2 USP20 RFWD3 LARP4B TMEM131L CGNL1 NFAT5

1.90e-0399511611EFO_0004518
Diseasechronic kidney disease

BCAS3 GRIN2A BOD1L2 LARP4B NFAT5

2.41e-032351165EFO_0003884
DiseaseOvarian Failure, Premature

STAG3 NOBOX

3.06e-03211162C0085215
Diseaseintellectual disability (implicated_via_orthology)

KDM5A UBR4 BOD1L2

3.25e-03751163DOID:1059 (implicated_via_orthology)
Diseaseatrial fibrillation

BICRA LRRC10 ALPK1 ITPR2 KIF3C CGNL1

3.53e-033711166EFO_0000275

Protein segments in the cluster

PeptideGeneStartEntry
PLAPNQPVHGTQADQ

ATG13

311

O75143
RLNNNHLPNSGEAIP

CFAP54

951

Q96N23
EPGAASPQRQQDLHL

CCDC86

86

Q9H6F5
PPANDNQLHDGLRQS

BOD1L2

91

Q8IYS8
ENNHPNPFLTNALLG

BAZ2B

476

Q9UIF8
NPFLTNALLGNHQPN

BAZ2B

481

Q9UIF8
PAPADGHVLLQLNSQ

CNTNAP4

901

Q9C0A0
ICLPSEHNPGNQNDF

AKAP11

836

Q9UKA4
NAQHDLPLSNPVQKD

GKAP1

91

Q5VSY0
VNGLPNENNSSDHLP

ANGEL2

521

Q5VTE6
QPPFNANHPLLLAAD

BCAS3

666

Q9H6U6
QELNGLALPQHEPND

CDAN1

596

Q8IWY9
HDLSLQEPNNDNLEP

ALPK1

646

Q96QP1
LAENTGPNSPDHQQL

ARHGEF39

166

Q8N4T4
ASNGNPDLHLQDLEP

IGDCC4

1141

Q8TDY8
QVQLNHAEQQPAPAG

RFWD3

11

Q6PCD5
HPDIFQLNNPDKGNV

RALGPS1

506

Q5JS13
KNEADHGQQAPPNTD

PCDHGA8

801

Q9Y5G5
PVNAGQPLHASNIEL

ITPR2

186

Q14571
QPLHASNIELLDNPG

ITPR2

191

Q14571
SGQHPLNGQPLIEQE

LUZP4

101

Q9P127
LAQSNQNRDHKQGPP

NOBOX

251

O60393
TIHNNLTEFQNDPPA

OOSP3

126

A0A2R8YFM6
LQDPNPSGLQTLAHQ

ANKRD31

341

Q8N7Z5
HSFNSQGPQQPDLII

PCDH19

851

Q8TAB3
VQDVNDHGPAFPLNL

DCHS1

2696

Q96JQ0
PGDLPEHTNHLSLQN

PODN

91

Q7Z5L7
QPHTQQGPEKLAGNA

LRRC37A3

1216

O60309
QPHTQQGPEKLAGNA

LRRC37A2

1216

A6NM11
QPHTQQGPEKLAGNA

LRRC37A

1216

A6NMS7
KVNGHDQGQNPPLDL

GNPTAB

796

Q3T906
NHNNAKEPDSEQQPL

MGA

1276

Q8IWI9
NLSHNQLPALPAQLG

MFHAS1

141

Q9Y4C4
ESLPNLQEVGLHGNP

LRRN2

356

O75325
DQENNPALPGTHALV

AQP7P3

191

A6NL99
DQENNPALPGTHALV

AQP7B

196

A0A075B734
DNHDPPNQSGLQRFV

FREM2

676

Q5SZK8
NPNIPNEIIHALQAG

HNRNPM

186

P52272
LSQGQNPDRQPHDLS

LRP5

1016

O75197
QGHENAALPDPQESD

LARP4B

106

Q92615
DDNNNNHRPPQPILE

KIF3C

436

O14782
NNLAFPAHPQDVDGK

NHSL1

526

Q5SYE7
QPEDSQQDLPGERHA

PLXNB2

1566

O15031
RNTDHQLDESQGPPL

OIT3

36

Q8WWZ8
QLDESQGPPLCDNHV

OIT3

41

Q8WWZ8
ALQGQHPPCSANEDL

RASGRP4

391

Q8TDF6
PSQELPQEDSLLHGQ

MANSC1

131

Q9H8J5
KHPEAPLQNTNANLN

GABRA4

371

P48169
DNHLNSLPPELGQLQ

LRRC10

61

Q5BKY1
PNHELQENLSEAPCQ

LRRC8E

56

Q6NSJ5
DQREALSHGQNPLPI

PLA2G4B

421

P0C869
GLTFNHDPPLSQNQR

MON2

846

Q7Z3U7
GLIDHNFQAQPNPAE

NUDT7

126

P0C024
GAHDPPAQVLQELNV

PRTN3

161

P24158
ESNHPIVLGPNNTNL

IPO5

1021

O00410
DRPAEQFHLQNNAPG

ARHGAP32

1101

A7KAX9
DQHPDSAPRQGLQVL

INSM2

376

Q96T92
LFHPQNPIADAQNLS

NFAT5

1071

O94916
LDSPGAQAQADHLPQ

GORASP1

371

Q9BQQ3
AQAQADHLPQLTLPD

GORASP1

376

Q9BQQ3
QKAAANPDLQGHLPS

KDM5A

1301

P29375
NPDLQGHLPSFQQSA

KDM5A

1306

P29375
DALQGFLSPLNPAHQ

PIK3CA

746

P42336
NEQPEANLDLSGNPR

PCDHA1

786

Q9Y5I3
LHNNQLSNAGLPPDA

PODNL1

176

Q6PEZ8
FLPLNAQENHGLAVP

C6orf132

81

Q5T0Z8
HPQNQPNGLFPDVSD

CHD9

106

Q3L8U1
VLLDQLNPQGDPEHS

GFRA4

256

Q9GZZ7
LNPQGDPEHSLLQVS

GFRA4

261

Q9GZZ7
PLANSNHESPVNQLG

LINC02876

26

F2Z3M2
DPEKNELNLQNHQPS

CGNL1

156

Q0VF96
PEGRISHQFPLNNND

CPNE9

361

Q8IYJ1
DQKPPHDGALGSQQN

COBL

36

O75128
ILQLAQAQGLDPPTH

CC2D1B

666

Q5T0F9
PENHQYQQDLLNPDP

CEACAM19

276

Q7Z692
PNNAHILDGNAADLQ

GNPDA2

101

Q8TDQ7
NGLQPLPAHQENGFS

MAP7D1

786

Q3KQU3
AQELGIPLTPQHAQA

FAM186A

1356

A6NE01
VPQPGKANHEIDNNT

DZANK1

16

Q9NVP4
LHVQEASGNHLNPEP

BICRA

51

Q9NZM4
QENHPQESKGQPRSQ

CHGB

246

P05060
NLVEHPAQLNPPVDN

PRPF3

416

O43395
APSPGQQQQAAAHLL

FOXA2

336

Q9Y261
LQQVSPASLDPGHNL

HNF1B

381

P35680
CLNNDIPHSIPLEQG

FAN1

346

Q9Y2M0
TLLNPNLPNQNDGVD

RUNX2

481

Q13950
AEDFLDINGQPINPH

ATP6V1B1

141

P15313
HGQLANEAAFLPVPQ

SERGEF

241

Q9UGK8
RDLSPPDNHLSPQND

TRIM37

451

O94972
QAIDQAHSNADQPPV

TEX55

321

Q96M34
ENGHNENQIPPQILE

PPP4R4

351

Q6NUP7
HQPDLPEISRKNNGN

TMEM131L

1126

A2VDJ0
VLGPDHPDCAQSLNN

NPHP3

1126

Q7Z494
GPNPEHNSNLANILE

TACO1

96

Q9BSH4
GSLHPGQLLQALENN

TAF1L

751

Q8IZX4
GNQEAANNPSSHPQL

TAF2

1016

Q6P1X5
QNFGQTPSQLLIEPH

NBEA

2546

Q8NFP9
LDGNSPPQRQDVDHD

HEPH

211

Q9BQS7
GENLPGDFQVPQALH

SLC35E2A

236

P0CK97
PGPSHNQAANDIVNP

RNF216

101

Q9NWF9
LPHLPQQNVVINGNA

TSC22D1

201

Q15714
RPDNNQALSNHLCPG

PLK4

446

O00444
SHSGEENLNPVPQLD

SOX30

701

O94993
HQSQESPNLENIANP

CLMN

836

Q96JQ2
QLSQLPPHSIDQGAE

CTNNBIP1

51

Q9NSA3
SNFLDLNLPPQHNTG

CNOT4

521

O95628
ATDDGHNNNLLPQII

ZNF451

236

Q9Y4E5
EPLADFNLQNNQHTP

TRMO

171

Q9BU70
QQAANQPLDSPLCHQ

TEP1

1626

Q99973
QEHGPQGLNELPAFI

STAG3

941

Q9UJ98
PASHDLHLAQGDPNQ

TEX37

111

Q96LM6
LHLAQGDPNQVLQSA

TEX37

116

Q96LM6
LGPLNLQDPFDLSHN

TUT1

536

Q9H6E5
GDHLQPLDLVPNHQG

TRPV6

266

Q9H1D0
SVAQPLGPENLHGEQ

USP20

891

Q9Y2K6
HSENNQDKGLPRPDN

YLPM1

991

P49750
QDLLELSPPENGHQS

XPOT

571

O43592
QGDQNDLENGPHSPL

SCN11A

1756

Q9UI33
DLENGPHSPLQTLCN

SCN11A

1761

Q9UI33
ENGAHSQLAEPQDLP

TBX4

306

P57082
ENDNFQDDPHAGLPQ

ZNHIT1

36

O43257
PQDVQQGAHAQPTLQ

TRIM66

416

O15016
NVNNGNPSPLEALLA

UBR4

2781

Q5T4S7
EQAANQPAPGHPNSI

TBC1D2B

201

Q9UPU7
GDHLQPLDLVPNHQG

TRPV5

226

Q9NQA5
HEFAENPGLIDNPNL

LPIN2

496

Q92539
PMNRNPLHNEEGLSN

GRIN2A

1166

Q12879