Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	aspartic-type endopeptidase activity	ERVK-6 ERVK-7 ERVK-9 ERVK-10 ERVK-8 ERVK-18 ERVK-19 ERVK-25	1.30e-11	37	103	8	GO:0004190
GeneOntologyMolecularFunction	aspartic-type peptidase activity	ERVK-6 ERVK-7 ERVK-9 ERVK-10 ERVK-8 ERVK-18 ERVK-19 ERVK-25	1.64e-11	38	103	8	GO:0070001
GeneOntologyMolecularFunction	RNA-DNA hybrid ribonuclease activity	ERVK-6 ERVK-7 ERVK-10 ERVK-8 ERVK-11	1.49e-09	11	103	5	GO:0004523
GeneOntologyMolecularFunction	RNA-directed DNA polymerase activity	ERVK-6 ERVK-7 ERVK-10 ERVK-8 ERVK-11	6.39e-09	14	103	5	GO:0003964
GeneOntologyMolecularFunction	RNA stem-loop binding	ERVK-6 ERVK-7 ERVK-10 ERVK-8 ERVK-11	6.31e-08	21	103	5	GO:0035613
GeneOntologyMolecularFunction	RNA endonuclease activity, producing 5'-phosphomonoesters	ERVK-6 ERVK-7 ERVK-10 ERVK-8 ERVK-11	1.27e-06	37	103	5	GO:0016891
GeneOntologyMolecularFunction	DNA polymerase activity	ERVK-6 ERVK-7 ERVK-10 ERVK-8 ERVK-11	1.45e-06	38	103	5	GO:0034061
GeneOntologyMolecularFunction	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	ERVK-6 ERVK-7 ERVK-10 ERVK-8 ERVK-11	3.84e-06	46	103	5	GO:0016893
GeneOntologyMolecularFunction	zinc ion binding	ERVK-6 MYCBP2 LITAF ZNF407 BIRC5 ERVK-7 IDE ERVK-9 CPN1 ERVK-10 SIRT2 ERVK-8 ERVK-19 ERVK-11 USP3	5.12e-05	891	103	15	GO:0008270
GeneOntologyMolecularFunction	RNA endonuclease activity	ERVK-6 ERVK-7 ERVK-10 ERVK-8 ERVK-11	5.51e-05	79	103	5	GO:0004521
GeneOntologyMolecularFunction	endopeptidase activity	ERVK-6 CAPN1 ERVK-7 IDE ERVK-9 ERVK-10 ERVK-8 ERVK-18 ERVK-19 ERVK-25	7.65e-05	430	103	10	GO:0004175
GeneOntologyMolecularFunction	protein-L-isoaspartate (D-aspartate) O-methyltransferase activity	PCMTD1 PCMTD2	7.88e-05	3	103	2	GO:0004719
GeneOntologyMolecularFunction	transition metal ion binding	ERVK-6 CYP4F8 MYCBP2 LITAF ZNF407 BIRC5 ERVK-7 IDE ERVK-9 CPN1 ERVK-10 SIRT2 ERVK-8 ERVK-19 ERVK-11 USP3 CYP4F11	1.17e-04	1189	103	17	GO:0046914
GeneOntologyMolecularFunction	peptidase activity	ERVK-6 CAPN1 ERVK-7 IDE ERVK-9 CPN1 ERVK-10 ERVK-8 ERVK-18 ERVK-19 ERVK-25 USP3	1.39e-04	654	103	12	GO:0008233
GeneOntologyMolecularFunction	G protein-coupled receptor activity	OR7G1 OR7E24 OR4K2 OR4E1 MC3R GPRC5C OPRM1 NLRP6 FZD8 OR2B11 OR7D2 OR4B1 OR7G3 OR7G2	1.77e-04	884	103	14	GO:0004930
GeneOntologyMolecularFunction	alpha-tocopherol omega-hydroxylase activity	CYP4F8 CYP4F11	2.61e-04	5	103	2	GO:0052871
GeneOntologyMolecularFunction	calcium, potassium:sodium antiporter activity	SLC24A3 SLC24A4	2.61e-04	5	103	2	GO:0008273
GeneOntologyMolecularFunction	melanocortin receptor activity	MC3R OPRM1	3.90e-04	6	103	2	GO:0004977
GeneOntologyMolecularFunction	olfactory receptor activity	OR7G1 OR7E24 OR4K2 OR4E1 OR2B11 OR7D2 OR4B1 OR7G3 OR7G2	3.92e-04	431	103	9	GO:0004984
GeneOntologyMolecularFunction	protein carboxyl O-methyltransferase activity	PCMTD1 PCMTD2	5.44e-04	7	103	2	GO:0051998
GeneOntologyMolecularFunction	leukotriene-B4 20-monooxygenase activity	CYP4F8 CYP4F11	5.44e-04	7	103	2	GO:0050051
GeneOntologyMolecularFunction	alkane 1-monooxygenase activity	CYP4F8 CYP4F11	5.44e-04	7	103	2	GO:0018685
GeneOntologyMolecularFunction	carboxyl-O-methyltransferase activity	PCMTD1 PCMTD2	5.44e-04	7	103	2	GO:0010340
GeneOntologyMolecularFunction	RNA nuclease activity	ERVK-6 ERVK-7 ERVK-10 ERVK-8 ERVK-11	6.98e-04	136	103	5	GO:0004540
GeneOntologyMolecularFunction	endonuclease activity	ERVK-6 ERVK-7 ERVK-10 ERVK-8 ERVK-11	6.98e-04	136	103	5	GO:0004519
GeneOntologyMolecularFunction	nucleotidyltransferase activity	ERVK-6 ERVK-7 ERVK-10 ERVK-8 ERVK-11	1.15e-03	152	103	5	GO:0016779
GeneOntologyMolecularFunction	arachidonate omega-hydroxylase activity	CYP4F8 CYP4F11	1.15e-03	10	103	2	GO:0052869
GeneOntologyMolecularFunction	calcium:sodium antiporter activity	SLC24A3 SLC24A4	1.15e-03	10	103	2	GO:0005432
GeneOntologyMolecularFunction	fatty acid omega-hydroxylase activity	CYP4F8 CYP4F11	1.15e-03	10	103	2	GO:0120250
GeneOntologyMolecularFunction	long-chain fatty acid omega-hydroxylase activity	CYP4F8 CYP4F11	1.15e-03	10	103	2	GO:0102033
GeneOntologyMolecularFunction	nuclease activity	ERVK-6 ASTE1 ERVK-7 ERVK-10 ERVK-8 ERVK-11	1.26e-03	231	103	6	GO:0004518
GeneOntologyMolecularFunction	metal cation:monoatomic cation antiporter activity	SLC24A3 SLC30A1 SLC24A4	1.42e-03	43	103	3	GO:0140828
GeneOntologyMolecularFunction	transmembrane signaling receptor activity	OR7G1 OR7E24 OR4K2 NTRK2 OR4E1 MC3R GPRC5C OPRM1 NLRP6 FZD8 OR2B11 OR7D2 OR4B1 OR7G3 OR7G2 NOTCH1	1.50e-03	1353	103	16	GO:0004888
GeneOntologyMolecularFunction	extracellular matrix constituent conferring elasticity	LAMC1 FBN1	1.68e-03	12	103	2	GO:0030023
GeneOntologyMolecularFunction	calcium:monoatomic cation antiporter activity	SLC24A3 SLC24A4	1.98e-03	13	103	2	GO:0015368
GeneOntologyMolecularFunction	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen	CYP4F8 CYP4F11	1.98e-03	13	103	2	GO:0016713
GeneOntologyMolecularFunction	structural molecule activity	ERVK-6 LAMC1 SPOCK2 ERVK-7 ERVK-9 ERVK-10 FBN1 ERVK-8 ERVK-18 TMEM30A ERVK-19 ERVK-25	2.12e-03	891	103	12	GO:0005198
GeneOntologyMolecularFunction	structural molecule activity conferring elasticity	LAMC1 FBN1	2.30e-03	14	103	2	GO:0097493
GeneOntologyMolecularFunction	arachidonate binding	CYP4F8 CYP4F11	2.65e-03	15	103	2	GO:0050544
GeneOntologyMolecularFunction	icosanoid binding	CYP4F8 CYP4F11	3.02e-03	16	103	2	GO:0050542
GeneOntologyMolecularFunction	icosatetraenoic acid binding	CYP4F8 CYP4F11	3.02e-03	16	103	2	GO:0050543
GeneOntologyMolecularFunction	solute:potassium antiporter activity	SLC24A3 SLC24A4	4.26e-03	19	103	2	GO:0022821
GeneOntologyMolecularFunction	ubiquitin-modified protein reader activity	PEX1 IDE	4.71e-03	20	103	2	GO:0140036
GeneOntologyBiologicalProcess	DNA integration	ERVK-6 ERVK-7 ERVK-10 ERVK-8 ERVK-11	3.34e-09	13	102	5	GO:0015074
GeneOntologyBiologicalProcess	DNA synthesis involved in DNA repair	ERVK-6 ERVK-7 ERVK-10 SYCP1 ERVK-8 ERVK-11	1.31e-07	48	102	6	GO:0000731
GeneOntologyBiologicalProcess	DNA biosynthetic process	ERVK-6 NVL ERVK-7 ERVK-10 LIN9 SYCP1 ERVK-8 ERVK-11	1.28e-05	218	102	8	GO:0071897
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception of smell	OR7G1 OR7E24 OR4K2 OR4E1 OR2B11 SLC24A4 OR7D2 OR4B1 OR7G3 OR7G2	5.60e-05	432	102	10	GO:0050911
GeneOntologyBiologicalProcess	RNA-templated DNA biosynthetic process	ERVK-6 ERVK-7 ERVK-10 ERVK-8 ERVK-11	5.73e-05	83	102	5	GO:0006278
GeneOntologyBiologicalProcess	sensory perception of smell	OR7G1 OR7E24 OR4K2 OR4E1 OR2B11 SLC24A4 OR7D2 OR4B1 OR7G3 OR7G2	1.03e-04	465	102	10	GO:0007608
Domain	PCMT	PCMTD1 PCMTD2	7.02e-05	3	91	2	IPR000682
Domain	PCMT	PCMTD1 PCMTD2	7.02e-05	3	91	2	PS01279
Domain	zf-RING_9	PLEKHM1 RUBCN	2.33e-04	5	91	2	PF13901
Domain	K/Na/Ca-exchanger	SLC24A3 SLC24A4	2.33e-04	5	91	2	IPR004481
Domain	DUF4206	PLEKHM1 RUBCN	2.33e-04	5	91	2	SM01175
Domain	Zf-RING_9	PLEKHM1 RUBCN	2.33e-04	5	91	2	IPR025258
Domain	Olfact_rcpt	OR7G1 OR7E24 OR4K2 OR2B11 OR7D2 OR4B1 OR7G3 OR7G2	6.64e-04	393	91	8	IPR000725
Domain	-	CAND2 ARFGEF2 HEATR1 ELMO1 AP1G1 BRAT1	7.58e-04	222	91	6	1.25.10.10
Domain	NaCa_Exmemb	SLC24A3 SLC24A4	8.27e-04	9	91	2	IPR004837
Domain	Na_Ca_ex	SLC24A3 SLC24A4	8.27e-04	9	91	2	PF01699
Domain	-	SWT1 ASTE1	1.50e-03	12	91	2	3.40.50.1010
Domain	GPCR_Rhodpsn_7TM	OR7G1 OR7E24 OR4K2 MC3R OPRM1 OR2B11 OR7D2 OR4B1 OR7G3 OR7G2	1.55e-03	670	91	10	IPR017452
Domain	HEAT	CAND2 HEATR1 BRAT1	1.65e-03	48	91	3	PF02985
Domain	7tm_1	OR7G1 OR7E24 OR4K2 MC3R OPRM1 OR2B11 OR7D2 OR4B1 OR7G3 OR7G2	1.67e-03	677	91	10	PF00001
Domain	G_PROTEIN_RECEP_F1_1	OR7G1 OR7E24 OR4K2 MC3R OPRM1 OR2B11 OR7D2 OR4B1 OR7G3 OR7G2	1.83e-03	685	91	10	PS00237
Domain	G_PROTEIN_RECEP_F1_2	OR7G1 OR7E24 OR4K2 MC3R OPRM1 OR2B11 OR7D2 OR4B1 OR7G3 OR7G2	1.95e-03	691	91	10	PS50262
Domain	GPCR_Rhodpsn	OR7G1 OR7E24 OR4K2 MC3R OPRM1 OR2B11 OR7D2 OR4B1 OR7G3 OR7G2	1.97e-03	692	91	10	IPR000276
Domain	PIN_domain-like	SWT1 ASTE1	2.06e-03	14	91	2	IPR029060
Domain	ARM-like	CAND2 ARFGEF2 HEATR1 ELMO1 AP1G1 BRAT1	2.06e-03	270	91	6	IPR011989
Domain	HEAT	CAND2 HEATR1 BRAT1	2.84e-03	58	91	3	IPR000357
Domain	RUN	PLEKHM1 RUBCN	3.41e-03	18	91	2	SM00593
Domain	RUN	PLEKHM1 RUBCN	3.80e-03	19	91	2	PS50826
Domain	RUN	PLEKHM1 RUBCN	3.80e-03	19	91	2	PF02759
Domain	Run_dom	PLEKHM1 RUBCN	3.80e-03	19	91	2	IPR004012
Domain	RCC1	MYCBP2 HERC4	4.21e-03	20	91	2	PF00415
Domain	RCC1_1	MYCBP2 HERC4	4.64e-03	21	91	2	PS00625
Domain	RCC1_2	MYCBP2 HERC4	4.64e-03	21	91	2	PS00626
Domain	RCC1_3	MYCBP2 HERC4	4.64e-03	21	91	2	PS50012
Domain	HEAT_REPEAT	CAND2 HEATR1 BRAT1	4.84e-03	70	91	3	PS50077
Domain	Reg_chr_condens	MYCBP2 HERC4	5.09e-03	22	91	2	IPR000408
Domain	-	MYCBP2 HERC4	5.09e-03	22	91	2	2.130.10.30
Domain	RCC1/BLIP-II	MYCBP2 HERC4	5.56e-03	23	91	2	IPR009091
Domain	ARM-type_fold	CAND2 ARFGEF2 HEATR1 ELMO1 AP1G1 BRAT1	6.26e-03	339	91	6	IPR016024
Pubmed	A revised nomenclature for transcribed human endogenous retroviral loci.	ERVK-6 ERVK-7 ERVK-9 ERVK-10 ERVK-8 ERVK-18 ERVK-19 ERVK-25 ERVK-11	1.16e-11	94	104	9	21542922
Pubmed	Quantitation of HERV-K env gene expression and splicing in human breast cancer.	ERVK-6 ERVK-7 ERVK-18 ERVK-19	3.76e-10	5	104	4	12629516
Pubmed	Expression patterns of transcribed human endogenous retrovirus HERV-K(HML-2) loci in human tissues and the need for a HERV Transcriptome Project.	ERVK-9 ERVK-10 ERVK-18 ERVK-25 ERVK-11	1.80e-09	18	104	5	18664271
Pubmed	Identification of an active reverse transcriptase enzyme encoded by a human endogenous HERV-K retrovirus.	ERVK-6 ERVK-9 ERVK-11	2.60e-08	3	104	3	9971820
Pubmed	Genome-wide screening, cloning, chromosomal assignment, and expression of full-length human endogenous retrovirus type K.	ERVK-6 ERVK-18 ERVK-19	2.60e-08	3	104	3	10516026
Pubmed	Genomewide screening for fusogenic human endogenous retrovirus envelopes identifies syncytin 2, a gene conserved on primate evolution.	ERVK-6 ERVK-9 ERVK-8 ERVK-19	3.67e-08	12	104	4	14557543
Pubmed	Many human endogenous retrovirus K (HERV-K) proviruses are unique to humans.	ERVK-6 ERVK-7 ERVK-10	1.04e-07	4	104	3	10469592
Pubmed	Human endogenous retrovirus K10: expression of Gag protein and detection of antibodies in patients with seminomas.	ERVK-6 ERVK-10 ERVK-19	1.04e-07	4	104	3	7983737
Pubmed	Human endogenous retrovirus HERV-K(HML-2) proviruses with Rec protein coding capacity and transcriptional activity.	ERVK-6 ERVK-9 ERVK-19	5.16e-07	6	104	3	15063128
Pubmed	Odorant and vomeronasal receptor genes in two mouse genome assemblies.	OR7G1 OR4E1 OR4B1 OR7G3 OR7G2	2.97e-06	74	104	5	15081110
Pubmed	DEFOG: a practical scheme for deciphering families of genes.	OR7G1 OR7E24 OR4E1 OR7D2 OR4B1 OR7G3 OR7G2	4.51e-06	219	104	7	12213199
Pubmed	Different evolutionary processes shaped the mouse and human olfactory receptor gene families.	OR7G1 OR7E24 OR4K2 OR4E1 OR2B11 OR4B1 OR7G3 OR7G2	8.76e-06	340	104	8	11875048
Pubmed	The olfactory receptor gene superfamily of the mouse.	OR7G1 OR7E24 OR4K2 OR4E1 OR2B11 OR4B1 OR7G3 OR7G2	8.76e-06	340	104	8	11802173
Pubmed	A functional Notch-survivin gene signature in basal breast cancer.	BIRC5 NOTCH1	8.86e-06	2	104	2	19025652
Pubmed	The Role of Survivin and Transcription Factor FOXP1 in Scarring After Glaucoma Surgery.	BIRC5 FOXP1	8.86e-06	2	104	2	35142784
Pubmed	Expression of human endogenous retrovirus type K envelope glycoprotein in insect and mammalian cells.	ERVK-6 ERVK-19	8.86e-06	2	104	2	9060628
Pubmed	Evolutionary relationships within a subgroup of HERV-K-related human endogenous retroviruses.	ERVK-6 ERVK-19	8.86e-06	2	104	2	9460924
Pubmed	Rubicon and PLEKHM1 negatively regulate the endocytic/autophagic pathway via a novel Rab7-binding domain.	PLEKHM1 RUBCN	8.86e-06	2	104	2	20943950
Pubmed	Interferon-alpha-induced endogenous superantigen. a model linking environment and autoimmunity.	ERVK-6 ERVK-18	8.86e-06	2	104	2	11672541
Pubmed	A unified nomenclature for vertebrate olfactory receptors.	OR7G1 OR7E24 OR4K2 OR4E1 OR2B11 OR4B1 OR7G3 OR7G2	9.34e-06	343	104	8	32295537
Pubmed	Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.	OR7G1 OR7E24 OR4K2 OR4E1 OR2B11 OR4B1 OR7G3 OR7G2	9.95e-06	346	104	8	14611657
Pubmed	Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.	FLII MYCBP2 CAPN1 NVL PEX1 HEATR1 IDE STK11IP FBN1 MTMR3 BRAT1	1.66e-05	754	104	11	33060197
Pubmed	Molecular dependence of estrogen receptor-negative breast cancer on a notch-survivin signaling axis.	BIRC5 NOTCH1	2.65e-05	3	104	2	18593928
Pubmed	Positive feedback loop between mitochondrial fission and Notch signaling promotes survivin-mediated survival of TNBC cells.	BIRC5 NOTCH1	2.65e-05	3	104	2	30323195
Pubmed	Disruption of mouse cytochrome p450 4f14 (Cyp4f14 gene) causes severe perturbations in vitamin E metabolism.	CYP4F8 CYP4F11	5.29e-05	4	104	2	22665481
Pubmed	Expression and catalytic activity of mouse leukotriene B4 omega-hydroxylase, CYP4F14.	CYP4F8 CYP4F11	5.29e-05	4	104	2	11185557
Pubmed	Cation dependencies and turnover rates of the human K⁺-dependent Na⁺-Ca²⁺ exchangers NCKX1, NCKX2, NCKX3 and NCKX4.	SLC24A3 SLC24A4	5.29e-05	4	104	2	26631410
Pubmed	Disruption of P450-mediated vitamin E hydroxylase activities alters vitamin E status in tocopherol supplemented mice and reveals extra-hepatic vitamin E metabolism.	CYP4F8 CYP4F11	8.80e-05	5	104	2	22969154
Pubmed	Expression of potassium-dependent sodium-calcium exchanger in the murine lens.	SLC24A3 SLC24A4	8.80e-05	5	104	2	29128492
Pubmed	Transcriptionally active HERV-K genes: identification, isolation, and chromosomal mapping.	ERVK-6 ERVK-7	8.80e-05	5	104	2	11401426
Pubmed	Cytochrome P4504f, a potential therapeutic target limiting neuroinflammation.	CYP4F8 CYP4F11	8.80e-05	5	104	2	21466787
Pubmed	An Interaction Landscape of Ubiquitin Signaling.	HECTD4 NVL LAMC1 PCMTD1 RBCK1 PCMTD2 USP3 HERC4	1.02e-04	481	104	8	28190767
Pubmed	Regulation of retinal progenitor expansion by Frizzled receptors: implications for microphthalmia and retinal coloboma.	FZD8 ARR3 NOTCH1	1.10e-04	31	104	3	22228100
Pubmed	The cytochrome P450 4 (CYP4) family.	CYP4F8 CYP4F11	1.32e-04	6	104	2	9068972
Pubmed	Histone methyltransferase DOT1L coordinates AR and MYC stability in prostate cancer.	FLII MYCBP2 HECTD4 NVL PPP1CB BRAT1	1.47e-04	264	104	6	32814769
Pubmed	Notch1 haploinsufficiency causes ascending aortic aneurysms in mice.	FBN1 NOTCH1	1.84e-04	7	104	2	29093270
Pubmed	Role of ω-hydroxylase in adenosine-mediated aortic response through MAP kinase using A2A-receptor knockout mice.	CYP4F8 CYP4F11	1.84e-04	7	104	2	22160543
Pubmed	Targeted deletion of numb and numblike in sensory neurons reveals their essential functions in axon arborization.	NTRK2 NOTCH1	1.84e-04	7	104	2	15598981
Pubmed	Activity-based E3 ligase profiling uncovers an E3 ligase with esterification activity.	MYCBP2 HECTD4 RBCK1 HERC4	1.95e-04	95	104	4	29643511
Pubmed	Aurora kinase A regulates Survivin stability through targeting FBXL7 in gastric cancer drug resistance and prognosis.	SWT1 BIRC5 FOXP1	2.03e-04	38	104	3	28218735
Pubmed	Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project.	LITAF SLC30A1 OPRM1	2.20e-04	39	104	3	21347282
Pubmed	The human olfactory receptor gene family.	OR7G1 OR7E24 OR4K2 OR4E1 OR7D2 OR4B1 OR7G3 OR7G2	2.27e-04	541	104	8	14983052
Pubmed	Targeting RICTOR Sensitizes SMAD4-Negative Colon Cancer to Irinotecan.	HECTD4 CPT2 GLMN AP1G1 HERC4	2.30e-04	183	104	5	31932471
Pubmed	EMILIN proteins are novel extracellular constituents of the dentin-pulp complex.	LAMC1 FBN1	2.45e-04	8	104	2	32948785
Pubmed	Genome-wide association study of bipolar disorder in European American and African American individuals.	NTRK2 BTBD16	2.45e-04	8	104	2	19488044
Pubmed	A protein-protein interaction map of the TNF-induced NF-κB signal transduction pathway.	CNOT10 CAPN1 HEATR1 IDE RBCK1 HERC4	3.03e-04	302	104	6	30561431
Pubmed	Expert curation of the human and mouse olfactory receptor gene repertoires identifies conserved coding regions split across two exons.	OR7E24 OR4K2 OR7D2	3.59e-04	46	104	3	32126975
Pubmed	Survey of human genes of retroviral origin: identification and transcriptome of the genes with coding capacity for complete envelope proteins.	ERVK-6 ERVK-19	3.92e-04	10	104	2	12970426
Pubmed	PLEKHM1 regulates Salmonella-containing vacuole biogenesis and infection.	PLEKHM1 RUBCN	3.92e-04	10	104	2	25500191
Pubmed	Comparison of an expanded ataxia interactome with patient medical records reveals a relationship between macular degeneration and ataxia.	PPIG FBN1 GET3 NOTCH1	4.46e-04	118	104	4	21078624
Pubmed	Functional genomic landscape of cancer-intrinsic evasion of killing by T cells.	CNOT10 PEX1 COP1 ZNF407 HEATR1 RBCK1 GET3	4.59e-04	457	104	7	32968282
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	FLII MYCBP2 HECTD4 ARFGEF2 SPOCK2 RBCK1 NAA25 FBN1 DENND6B MTMR3 PCMTD2 ZNF583	4.64e-04	1285	104	12	35914814
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	FLII MYCBP2 HECTD4 ARFGEF2 CACFD1 STK11IP PLEKHM1 SIRT2 MTMR3 BRAT1 NOTCH1	4.78e-04	1105	104	11	35748872
Pubmed	CLEC16A interacts with retromer and TRIM27, and its loss impairs endosomal trafficking and neurodevelopment.	CAND2 MYCBP2 PEX1 HEATR1 STK11IP PPP1CB GLMN BRAT1	4.83e-04	606	104	8	36538041
Pubmed	LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.	CAND2 PEX1 GPRC5C HEATR1 GLMN NAA35 RAB3GAP1 NAA25 AP1G1 BRAT1	5.33e-04	942	104	10	31073040
Pubmed	A synopsis of eukaryotic Nalpha-terminal acetyltransferases: nomenclature, subunits and substrates.	NAA35 NAA25	5.73e-04	12	104	2	19660095
Pubmed	Compromised cell competition exhausts neural stem cells pool.	CACFD1 ELMO1	6.76e-04	13	104	2	39010274
Pubmed	MKRN2 Physically Interacts with GLE1 to Regulate mRNA Export and Zebrafish Retinal Development.	MYCBP2 CNOT10 RNF113A PPIG TMEM30A NOTCH1	7.42e-04	358	104	6	32460013
Pubmed	Basal progenitor cells in the embryonic mouse thalamus - their molecular characterization and the role of neurogenins and Pax6.	INSM1 NOTCH1	7.87e-04	14	104	2	22077982
Pubmed	The DNA sequence, annotation and analysis of human chromosome 3.	CAND2 ERVK-11 RUBCN	8.64e-04	62	104	3	16641997
Pubmed	FBXO45-MYCBP2 regulates mitotic cell fate by targeting FBXW7 for degradation.	MYCBP2 NOTCH1	9.07e-04	15	104	2	31285543
Pubmed	Active conformation of the p97-p47 unfoldase complex.	IDE GET3	9.07e-04	15	104	2	35552390
Pubmed	Selective disruption of trigeminal sensory neurogenesis and differentiation in a mouse model of 22q11.2 deletion syndrome.	NTRK2 FBN1	9.07e-04	15	104	2	33722956
Pubmed	Second-generation Notch1 activity-trap mouse line (N1IP::CreHI) provides a more comprehensive map of cells experiencing Notch1 activity.	FOXP1 NOTCH1	9.07e-04	15	104	2	25725069
Pubmed	The DNA sequence and comparative analysis of human chromosome 20.	INSM1 MC3R ARFGEF2 SLC24A3 TTPAL RBCK1 PCMTD2	9.46e-04	517	104	7	11780052
Pubmed	A ZFYVE21-Rubicon-RNF34 signaling complex promotes endosome-associated inflammasome activity in endothelial cells.	FLII RUBCN	1.03e-03	16	104	2	37225719
Pubmed	Loss of Intercalated Cells (ITCs) in the Mouse Amygdala of Tshz1 Mutants Correlates with Fear, Depression, and Social Interaction Phenotypes.	OPRM1 FOXP1	1.03e-03	16	104	2	29255003
Pubmed	Interaction of YAP with the Myb-MuvB (MMB) complex defines a transcriptional program to promote the proliferation of cardiomyocytes.	BIRC5 LIN9	1.03e-03	16	104	2	32469866
Pubmed	Chromosomal location-dependent nonstochastic onset of odor receptor expression.	OR4E1 OR7G2	1.17e-03	17	104	2	20668191
Pubmed	Local anesthetics impair the growth and self-renewal of glioblastoma stem cells by inhibiting ZDHHC15-mediated GP130 palmitoylation.	LAMC1 FBN1 MTMR3	1.28e-03	71	104	3	33541421
Pubmed	Beclin 2 functions in autophagy, degradation of G protein-coupled receptors, and metabolism.	OPRM1 RUBCN	1.31e-03	18	104	2	23954414
Pubmed	ADAMTS18-fibronectin interaction regulates the morphology of liver sinusoidal endothelial cells.	LAMC1 FBN1	1.31e-03	18	104	2	39040056
Pubmed	Autism-like phenotype and risk gene mRNA deadenylation by CPEB4 mis-splicing.	ZBTB20 FOXP1	1.31e-03	18	104	2	30111840
Pubmed	Impact of ancestry and common genetic variants on QT interval in African Americans.	LITAF FOXP1	1.46e-03	19	104	2	23166209
Pubmed	The glomuvenous malformation protein Glomulin binds Rbx1 and regulates cullin RING ligase-mediated turnover of Fbw7.	GLMN NOTCH1	1.46e-03	19	104	2	22405651
Pubmed	A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.	SPOCK2 IDE CPN1 CC2D2B BTBD16 HERC4	1.58e-03	415	104	6	16385451
Pubmed	The LIM homeobox gene Isl1 is required for the correct development of the striatonigral pathway in the mouse.	OPRM1 FOXP1	1.62e-03	20	104	2	24082127
Pubmed	VCP phosphorylation-dependent interaction partners prevent apoptosis in Helicobacter pylori-infected gastric epithelial cells.	CNOT10 ARFGEF2 HEATR1 RAB3GAP1 BRAT1	1.77e-03	288	104	5	23383273
Pubmed	Developmental SHP2 dysfunction underlies cardiac hypertrophy in Noonan syndrome with multiple lentigines.	FOXP1 NOTCH1	1.79e-03	21	104	2	27348588
Pubmed	Population-based genome-wide association studies reveal six loci influencing plasma levels of liver enzymes.	CACFD1 CPN1	1.79e-03	21	104	2	18940312
Pubmed	Temporal patterning of apical progenitors and their daughter neurons in the developing neocortex.	ZBTB20 NTRK2 FOXP1	1.94e-03	82	104	3	31073041
Pubmed	Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain.	SPOCK2 BICRAL RUBCN	2.01e-03	83	104	3	9039502
Pubmed	Functional proteomics mapping of a human signaling pathway.	MYCBP2 LITAF ARFGEF2 LAMC1 PPP1CB AP1G1 RUBCN	2.03e-03	591	104	7	15231748
Pubmed	Expression profile analysis of vulnerable CA1 pyramidal neurons in young-Middle-Aged Ts65Dn mice.	NTRK2 CAPN1 PPP1CB	2.15e-03	85	104	3	25131634
Pubmed	Slit/Robo signaling modulates the proliferation of central nervous system progenitors.	FOXP1 NOTCH1	2.15e-03	23	104	2	23083737
Pubmed	Hepatitis B Virus HBx Protein Mediates the Degradation of Host Restriction Factors through the Cullin 4 DDB1 E3 Ubiquitin Ligase Complex.	LAMC1 IDE SIRT2 AP1G1 SYCP1	2.24e-03	304	104	5	32235678
Pubmed	Specific repertoire of olfactory receptor genes in the male germ cells of several mammalian species.	OR7E24 OR4B1	2.34e-03	24	104	2	9119360
Pubmed	Neural crest cell-autonomous roles of fibronectin in cardiovascular development.	LAMC1 NOTCH1	2.34e-03	24	104	2	26552887
Pubmed	Ezh2 represses the basal cell lineage during lung endoderm development.	FOXP1 NOTCH1	2.34e-03	24	104	2	25516972
Pubmed	Zbtb20 modulates the sequential generation of neuronal layers in developing cortex.	ZBTB20 FOXP1	2.54e-03	25	104	2	27282384
Pubmed	The Zinc Finger Transcription Factor Sp9 Is Required for the Development of Striatopallidal Projection Neurons.	NTRK2 FOXP1	2.54e-03	25	104	2	27452460
Pubmed	VAPB/ALS8 interacts with FFAT-like proteins including the p97 cofactor FAF1 and the ASNA1 ATPase.	RAB3GAP1 GET3	2.54e-03	25	104	2	24885147
Pubmed	Developmental diversification of cortical inhibitory interneurons.	INSM1 FOXP1 NOTCH1	2.61e-03	91	104	3	29513653
Pubmed	Defining the membrane proteome of NK cells.	MYCBP2 CNOT10 NVL ARFGEF2 TTPAL HEATR1 ELMO1 AP1G1 TMEM30A BRAT1	2.65e-03	1168	104	10	19946888
Pubmed	The structural role of radial glial endfeet in confining spinal motor neuron somata is controlled by the Reelin and Notch pathways.	FOXP1 NOTCH1	2.75e-03	26	104	2	23988635
Pubmed	Adamts18 modulates the development of the aortic arch and common carotid artery.	LAMC1 FBN1	2.75e-03	26	104	2	34189436
Pubmed	Type 2 diabetes risk alleles near ADCY5, CDKAL1 and HHEX-IDE are associated with reduced birthweight.	IDE NOTCH1	2.96e-03	27	104	2	20490451
Pubmed	Maternal NAT10 orchestrates oocyte meiotic cell-cycle progression and maturation in mice.	BIRC5 SYCP1	2.96e-03	27	104	2	37349316
Pubmed	Combining genetic markers and clinical risk factors improves the risk assessment of impaired glucose metabolism.	IDE OPRM1	2.96e-03	27	104	2	20384434
Pubmed	Brg1 coordinates multiple processes during retinogenesis and is a tumor suppressor in retinoblastoma.	ARR3 NOTCH1	2.96e-03	27	104	2	26628093
Cytoband	19p13.2	OR7G1 OR7E24 OR7D2 OR7G3 OR7G2 ZNF564	1.38e-05	229	103	6	19p13.2
Cytoband	6q14.1	BCKDHB ERVK-9 TMEM30A	2.14e-05	24	103	3	6q14.1
Cytoband	Ensembl 112 genes in cytogenetic band chr19p13	OR7G1 CYP4F8 OR7E24 OR7D2 GET3 OR7G3 OR7G2 ZNF564 CYP4F11	8.04e-05	797	103	9	chr19p13
GeneFamily	Olfactory receptors, family 7	OR7G1 OR7E24 OR7D2 OR7G3 OR7G2	3.34e-05	113	59	5	154
GeneFamily	N(alpha)-acetyltransferase subunits\|GCN5 related N-acetyltransferases	NAA35 NAA25	6.77e-04	12	59	2	660
Coexpression	GSE17721_CTRL_VS_GARDIQUIMOD_12H_BMDC_DN	MC3R SCRG1 BCKDHB LIN9 PPP1CB PPIG NAA35	7.96e-06	198	95	7	M3792
Coexpression	GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_DN	ZBTB20 HECTD4 PEX1 SLC30A1 STK11IP LIN9 FZD8 SIRT2 DENND6B TMEM30A FOXP1 CEP295 PCMTD2 RUBCN NOTCH1	9.73e-06	1102	95	15	M2369
Coexpression	GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_DN	ZBTB20 HECTD4 PEX1 SLC30A1 STK11IP LIN9 FZD8 SIRT2 DENND6B TMEM30A FOXP1 CEP295 PCMTD2 RUBCN NOTCH1	1.23e-05	1124	95	15	MM1070
CoexpressionAtlas	DevelopingLowerUrinaryTract_P1_bladder_J_emap-30374_k-means-cluster#1_top-relative-expression-ranked_1000	ZBTB20 MYCBP2 ARFGEF2 LAMC1 PCMTD1 WSCD2	3.20e-05	149	86	6	gudmap_developingLowerUrinaryTract_P1_bladder_J_1000_k1
CoexpressionAtlas	FacebaseRNAseq_e10.5_Maxillary Arch_top-relative-expression-ranked_2500_k-means-cluster#5	ZBTB20 CAND2 INSM1 ASTE1 ARFGEF2 COP1 ZNF407 LIN9 PPIG GJE1 CEP295	4.61e-05	629	86	11	Facebase_RNAseq_e10.5_Maxillary Arch_2500_K5
Disease	lung adenocarcinoma (biomarker_via_orthology)	FOXP1 NOTCH1	5.38e-05	4	89	2	DOID:3910 (biomarker_via_orthology)
Disease	Marfan Syndrome, Type I	LAMC1 FBN1	3.19e-04	9	89	2	C4721845
Disease	Marfan Syndrome	LAMC1 FBN1	4.86e-04	11	89	2	C0024796
Disease	Adenocarcinoma Of Esophagus	ELMO1 FOXP1	8.00e-04	14	89	2	C0279628
Disease	progression free survival, ovarian carcinoma	NTRK2 ELMO1	1.33e-03	18	89	2	EFO_0001075, EFO_0004920
Disease	congenital heart disease (is_implicated_in)	FOXP1 NOTCH1	2.38e-03	24	89	2	DOID:1682 (is_implicated_in)
Disease	Cerebral Astrocytoma	NTRK2 NOTCH1	2.58e-03	25	89	2	C0750935
Disease	Intracranial Astrocytoma	NTRK2 NOTCH1	2.58e-03	25	89	2	C0750936
Disease	Pilocytic Astrocytoma	NTRK2 NOTCH1	2.58e-03	25	89	2	C0334583
Disease	Astrocytoma	NTRK2 NOTCH1	2.58e-03	25	89	2	C0004114
Disease	Juvenile Pilocytic Astrocytoma	NTRK2 NOTCH1	2.58e-03	25	89	2	C0280783
Disease	Diffuse Astrocytoma	NTRK2 NOTCH1	2.58e-03	25	89	2	C0280785
Disease	Grade I Astrocytoma	NTRK2 NOTCH1	2.58e-03	25	89	2	C1704230
Disease	Subependymal Giant Cell Astrocytoma	NTRK2 NOTCH1	2.58e-03	25	89	2	C0205768
Disease	Mixed oligoastrocytoma	NTRK2 NOTCH1	2.58e-03	25	89	2	C0547065
Disease	Childhood Cerebral Astrocytoma	NTRK2 NOTCH1	2.58e-03	25	89	2	C0338070
Disease	brain cancer (implicated_via_orthology)	INSM1 NOTCH1	2.79e-03	26	89	2	DOID:1319 (implicated_via_orthology)
Disease	Gemistocytic astrocytoma	NTRK2 NOTCH1	2.79e-03	26	89	2	C0334581
Disease	Protoplasmic astrocytoma	NTRK2 NOTCH1	2.79e-03	26	89	2	C0334580
Disease	Fibrillary Astrocytoma	NTRK2 NOTCH1	2.79e-03	26	89	2	C0334582
Disease	attention deficit hyperactivity disorder, substance abuse, antisocial behaviour measurement	FLII ZBTB20 SLC24A3 ZNF407 ELMO1 WSCD2 FOXP1 BICRAL	2.91e-03	801	89	8	EFO_0003888, EFO_0007052, MONDO_0002491
Disease	Anaplastic astrocytoma	NTRK2 NOTCH1	3.01e-03	27	89	2	C0334579

Protein segments in the cluster

Peptide	Gene	Start	Entry
EPDLAQCFFCFKELE	BIRC5	51	O15392
SYEDKSNDFVCPICF	COP1	126	Q8NHY2
FDFAFCALFDCDRPV	BRAT1	701	Q6PJG6
SFEEFFCICIQLLNK	ELMO1	451	Q92556
FFKSFPENCCFLDRD	BTBD16	301	Q32M84
LLLCEAPFCCQFIEF	CACFD1	71	Q9UGQ2
VKCLSEFACNAAFPD	ARFGEF2	1271	Q9Y6D5
CVCVLFASVPDFKEF	ADCY4	871	Q8NFM4
PDLAVDFDNFVCCLV	CAPN1	666	P07384
YFDKLAPCLEAVCSE	DENND6B	176	Q8NEG7
FCPLKSVDCLFDDRN	CC2D2B	1241	Q6DHV5
PCGIDFEVKSFCAEN	ARR3	136	P36575
SDFCIFDLKTGFCPL	ASTE1	161	Q2TB18
AVFCLCLDDFPIKDL	CPT2	321	P23786
IVCDDFFVPSLEKIC	SLC24A4	116	Q8NFF2
AETLFQEICPNEDFC	CHM	591	P24386
QCLLGDFVTEFFKIC	RAB3GAP1	321	Q15042
KNSAPCVIFFDEVDA	NVL	671	O15381
CCFIPFCVDALQDVD	LITAF	131	Q99732
LYFLDSCEPEFKADC	AP1G1	386	O43747
LSCIEDKNPCIFFEP	BCKDHB	226	P21953
LDENFKRCFREFCIP	OPRM1	341	P35372
LDKINEFQCECPTGF	NOTCH1	506	P46531
NSEFCFILKVPFESE	FLII	1081	Q13045
IDKPLFEGDNDFCVC	LIN9	131	Q5TKA1
PLVLKEFDTAFSFDC	LINS1	681	Q8NG48
FFEDDVNEFTCPVCF	RBCK1	381	Q9BYM8
DKFEFCEPAFVVGNC	PCMTD1	136	Q96MG8
DKFDFCEPSFVTGNC	PCMTD2	136	Q9NV79
SFFCDLPVVFQLACV	OR4K2	176	Q8NGD2
QCLPDIDSEEYFCVK	HERC4	351	Q5GLZ8
PGCEAVCEDFQSFLK	FOXP1	311	Q9H334
CFFTIPLAEQDCEKF	HERVK_113	126	P63132
LFCEEFIQQCPAAVE	HECTD4	1876	Q9Y4D8
EEIPFKCFICRQSFQ	RNF113A	256	O15541
CFFTIPLAEQDCEKF	ERVK-7	126	P63135
CFFTIPLAEQDCEKF	ERVK-6	126	Q9BXR3
IVCDDFFVPSLEKIC	SLC24A3	126	Q9HC58
FFCEVPAVIKLSCAD	OR2B11	181	Q5JQS5
FELFSDVCPKTCENF	PPIG	26	Q13427
FCLVFACVVKPDFST	GPRC5C	101	Q9NQ84
LSFCKNVEIPLFFCE	OR7G1	166	Q8NGA0
FTDCFNCLPIAAIVD	PPP1CB	151	P62140
CFFTIPLAEQDCEKF	ERVK-18	126	Q9QC07
FCCEEFQPAKCTDKE	FAM189A2	51	Q15884
VEIQCSPDLKFFLCS	FZD8	76	Q9H461
DPEGFQADFCCSFKL	BICRAL	816	Q6AI39
NCFEITLELSCDKFP	CPN1	301	P15169
SKDFCNFLPTCLDLT	DMRT2	296	Q9Y5R5
CECPVGFFYNDKLLV	FBN1	1791	P35555
CVFSFESNCQEKPSE	CYP4F11	206	Q9HBI6
CIFSFDSNCQEKPSE	CYP4F8	206	P98187
FICDPDKREVNLFCY	GJE1	51	A6NN92
PCFCTINFTLEKSFE	TMEM30A	101	Q9NV96
SSAFCEQVFIKPEVF	MC3R	31	P41968
FKDPEQTTFICVCIA	GET3	236	O43681
TYGVDCEKCLPFFND	LAMC1	311	P11047
AQFFLCPLFDESCKD	IDE	166	P14735
EAFFDSENDPEKCCL	HEATR1	1976	Q9H583
ESCLQAFEAFLRKCP	CAND2	276	O75155
ENEAKCFFQVSEFLP	CEP295	2426	Q9C0D2
CEFCQNEDDIIFPFE	RUBCN	891	Q92622
YCLLCPEDKVAFEFV	DSEL	131	Q8IZU8
AAKPCILFFDEFESI	PEX1	931	O43933
KENETLFALCFVPFV	NLRP6	376	P59044
PCSFEFNEAFLVKLV	MTMR3	491	Q13615
CPEGKFYEDTLNFCV	OTOGL	781	Q3ZCN5
EFICQLCKEEYADPF	INSM1	266	Q01101
FCDLQPLFKLACTDT	OR4B1	176	Q8NGF8
CCKALIEFTKPFVEE	GLMN	176	Q92990
FPFEFDTTVRCAECK	PLEKHM1	1011	Q9Y4G2
FSDAQEEFQCCLKVP	STK11IP	801	Q8N1F8
CFKDVDISNFFCDPS	OR7E24	186	Q6IFN5
LSFCTDLEIPLFFCE	OR7G2	166	Q8NG99
LTFCIDLEIPHFFCE	OR7G3	166	Q8NG95
LFDEFDNIPCKKCVV	ST3GAL6	106	Q9Y274
CEDCQSLVKPDIVFF	SIRT2	221	Q8IXJ6
DFFKDINSCCPQEAT	MYCBP2	2561	O75592
LIFCKDFEIPHFFCE	OR7D2	166	Q96RA2
CNFSELLCCPKDVFF	SCRG1	71	O75711
QELFPCSFVILCTDD	SWT1	496	Q5T5J6
LKDCFFTIPLAEQDC	ERVK-9	1046	P63128
FTIPLAEQDCEKFAF	ERVK-9	1051	P63128
AEQDCEKFAFTIPAI	ERVK-9	1056	P63128
FDSCCIDQSPFQLVE	CLCN1	816	P35523
EPFEEKFAQAVCFLL	CNOT10	141	Q9H9A5
KVFLAECYNLCPEQD	NTRK2	551	Q16620
DFVKEFCQPVPACDS	TTPAL	296	Q9BTX7
CFFTIPLAEQDCEKF	ERVK-25	126	P63136
FSCEFCEQRFTEKGP	ZBTB48	521	P10074
ECQECAKAFISLPSF	ZNF564	226	Q8TBZ8
FFCDVPQVIKLACID	OR4E1	181	P0C645
ILDFFCEFSEQSPCV	NAA35	351	Q5VZE5
CTEDDFEFPFAKTNL	SYCP1	41	Q15431
VSDPCDFNKFILCNL	TRIL	576	Q7L0X0
CFFTIPLAEQDCEKF	ERVK-10	126	P10266
CFFTIPLAEQDCEKF	ERVK-8	126	P63133
CFFTIPLAEQDCEKF	ERVK-11	126	Q9UQG0
VCSVCPAKFDQIEQF	ZBTB20	716	Q9HC78
EQFCCYFKELPAVEL	USP3	181	Q9Y6I4
QENSFKCEVCEESFP	ZXDA	356	P98168
LKDCFFTIPLAEQDC	ERVK-19	126	Q9WJR5
FTIPLAEQDCEKFAF	ERVK-19	131	Q9WJR5
AEQDCEKFAFTIPAI	ERVK-19	136	Q9WJR5
LCTPCNLFFLSEKDV	ZNF407	616	Q9C0G0
FKCVKCTEPFDSEQN	ZNF407	1486	Q9C0G0
CVDFCTEKEYPLAAL	WSCD2	261	Q2TBF2
CFPDPCKAFVEIINS	SLC30A1	286	Q9Y6M5
ERPFECIECGKAFSN	ZNF583	321	Q96ND8
DKYEVCIRPFFNSCD	SPOCK2	276	Q92563
DKPCCFTDLKVFVDL	NAA25	361	Q14CX7