Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	histone deacetylase activity, NAD-dependent	SIRT2 SIRT3 SIRT1	7.94e-07	5	87	3	GO:0017136
GeneOntologyMolecularFunction	NAD-dependent protein lysine deacetylase activity	SIRT2 SIRT3 SIRT1	2.76e-06	7	87	3	GO:0034979
GeneOntologyMolecularFunction	histone H4K16 deacetylase activity, NAD-dependent	SIRT2 SIRT1	1.88e-05	2	87	2	GO:0046970
GeneOntologyMolecularFunction	NAD+ binding	SIRT2 SIRT3 SIRT1	8.63e-05	20	87	3	GO:0070403
GeneOntologyMolecularFunction	histone H4K deacetylase activity	SIRT2 SIRT1	1.12e-04	4	87	2	GO:0141051
GeneOntologyMolecularFunction	histone H4K16 deacetylase activity, hydrolytic mechanism	SIRT2 SIRT1	1.12e-04	4	87	2	GO:0034739
GeneOntologyMolecularFunction	histone deacetylase activity	SIRT2 SIRT3 SIRT1	1.51e-04	24	87	3	GO:0004407
GeneOntologyMolecularFunction	protein lysine deacetylase activity	SIRT2 SIRT3 SIRT1	1.71e-04	25	87	3	GO:0033558
GeneOntologyMolecularFunction	NAD+-protein poly-ADP-ribosyltransferase activity	SIRT2 SIRT3 SIRT1	2.42e-04	28	87	3	GO:0003950
GeneOntologyMolecularFunction	NAD+-protein ADP-ribosyltransferase activity	SIRT2 SIRT3 SIRT1	2.98e-04	30	87	3	GO:1990404
GeneOntologyMolecularFunction	deacetylase activity	SIRT2 SIRT3 SIRT1	7.02e-04	40	87	3	GO:0019213
GeneOntologyMolecularFunction	arrestin family protein binding	ITCH GPR61	1.20e-03	12	87	2	GO:1990763
GeneOntologyBiologicalProcess	protein deacylation	NEK3 SIRT2 ABHD12 SIRT3 SIRT1	3.84e-06	58	84	5	GO:0035601
GeneOntologyBiologicalProcess	macromolecule deacylation	NEK3 SIRT2 ABHD12 SIRT3 SIRT1	5.80e-06	63	84	5	GO:0098732
GeneOntologyBiologicalProcess	homophilic cell adhesion via plasma membrane adhesion molecules	FAT4 PSG9 PCDHA8 PCDHA6 PCDHA3 PCDHA2 PCDHA1	1.13e-05	187	84	7	GO:0007156
GeneOntologyBiologicalProcess	protein deacetylation	NEK3 SIRT2 SIRT3 SIRT1	3.99e-05	47	84	4	GO:0006476
GeneOntologyBiologicalProcess	cell-cell adhesion via plasma-membrane adhesion molecules	FAT4 PSG9 PCDHA8 PCDHA6 PCDHA3 PCDHA2 PCDHA1 FLRT3	4.12e-05	313	84	8	GO:0098742
GeneOntologyBiologicalProcess	sebum secreting cell proliferation	FA2H PRDM1	4.90e-05	3	84	2	GO:1990654
GeneOntologyBiologicalProcess	trophoblast giant cell differentiation	GJB5 SENP2 PRDM1	6.02e-05	19	84	3	GO:0060707
GeneOntologyBiologicalProcess	glycosylation	NPC1 CLN5 DERL3 A4GNT COG3 GALNT7 ATP4B	1.17e-04	270	84	7	GO:0070085
GeneOntologyBiologicalProcess	negative regulation of peptidyl-lysine acetylation	SIRT3 SIRT1	1.63e-04	5	84	2	GO:2000757
Domain	Cadherin_tail	PCDHA8 PCDHA6 PCDHA3 PCDHA2 PCDHA1	7.57e-07	37	87	5	PF15974
Domain	Cadherin_CBD	PCDHA8 PCDHA6 PCDHA3 PCDHA2 PCDHA1	7.57e-07	37	87	5	IPR031904
Domain	SIR2	SIRT2 SIRT3 SIRT1	3.37e-06	7	87	3	PF02146
Domain	Ssirtuin_cat_dom	SIRT2 SIRT3 SIRT1	3.37e-06	7	87	3	IPR026590
Domain	Sirtuin	SIRT2 SIRT3 SIRT1	3.37e-06	7	87	3	IPR003000
Domain	SIRTUIN	SIRT2 SIRT3 SIRT1	3.37e-06	7	87	3	PS50305
Domain	Cadherin_CS	FAT4 PCDHA8 PCDHA6 PCDHA3 PCDHA2 PCDHA1	1.18e-05	109	87	6	IPR020894
Domain	Cadherin_2	PCDHA8 PCDHA6 PCDHA3 PCDHA2 PCDHA1	1.29e-05	65	87	5	PF08266
Domain	Cadherin_N	PCDHA8 PCDHA6 PCDHA3 PCDHA2 PCDHA1	1.29e-05	65	87	5	IPR013164
Domain	CADHERIN_1	FAT4 PCDHA8 PCDHA6 PCDHA3 PCDHA2 PCDHA1	1.45e-05	113	87	6	PS00232
Domain	Cadherin	FAT4 PCDHA8 PCDHA6 PCDHA3 PCDHA2 PCDHA1	1.45e-05	113	87	6	PF00028
Domain	CADHERIN_2	FAT4 PCDHA8 PCDHA6 PCDHA3 PCDHA2 PCDHA1	1.53e-05	114	87	6	PS50268
Domain	-	FAT4 PCDHA8 PCDHA6 PCDHA3 PCDHA2 PCDHA1	1.53e-05	114	87	6	2.60.40.60
Domain	-	SIRT2 SIRT3 SIRT1	1.57e-05	11	87	3	3.40.50.1220
Domain	CA	FAT4 PCDHA8 PCDHA6 PCDHA3 PCDHA2 PCDHA1	1.61e-05	115	87	6	SM00112
Domain	Cadherin-like	FAT4 PCDHA8 PCDHA6 PCDHA3 PCDHA2 PCDHA1	1.69e-05	116	87	6	IPR015919
Domain	Cadherin	FAT4 PCDHA8 PCDHA6 PCDHA3 PCDHA2 PCDHA1	1.86e-05	118	87	6	IPR002126
Domain	DHS-like_NAD/FAD-binding_dom	SIRT2 SIRT3 SIRT1	2.08e-05	12	87	3	IPR029035
Domain	Sirtuin_class_I	SIRT2 SIRT3	2.14e-05	2	87	2	IPR017328
Domain	-	SIRT3 SIRT1	1.28e-04	4	87	2	3.30.1600.10
Domain	Sirtuin_cat_small_dom	SIRT3 SIRT1	1.28e-04	4	87	2	IPR026591
Domain	Fatty_acid_hydroxylase	SC5D FA2H	3.18e-04	6	87	2	IPR006694
Domain	FA_hydroxylase	SC5D FA2H	3.18e-04	6	87	2	PF04116
Domain	Alkaline_phosphatase_core	ARSJ ARSB ENPP3	3.99e-04	31	87	3	IPR017850
Domain	Alkaline_Pase-like_a/b/a	ARSJ ARSB ENPP3	3.99e-04	31	87	3	IPR017849
Domain	-	ARSJ ARSB ENPP3	3.99e-04	31	87	3	3.40.720.10
Domain	EXOIII	ERI3 REXO1L1P	1.88e-03	14	87	2	SM00479
Domain	Exonuclease_RNaseT/DNA_pol3	ERI3 REXO1L1P	1.88e-03	14	87	2	IPR013520
Domain	RNase_T	ERI3 REXO1L1P	1.88e-03	14	87	2	PF00929
Domain	TLC	CERS3 TRAM2	2.47e-03	16	87	2	PS50922
Domain	Sulfatase_CS	ARSJ ARSB	2.47e-03	16	87	2	IPR024607
Domain	TLC	CERS3 TRAM2	2.47e-03	16	87	2	SM00724
Domain	TRAM_LAG1_CLN8	CERS3 TRAM2	2.47e-03	16	87	2	PF03798
Domain	TLC-dom	CERS3 TRAM2	2.47e-03	16	87	2	IPR006634
Domain	SULFATASE_1	ARSJ ARSB	2.79e-03	17	87	2	PS00523
Domain	SULFATASE_2	ARSJ ARSB	2.79e-03	17	87	2	PS00149
Domain	Sulfatase	ARSJ ARSB	3.13e-03	18	87	2	PF00884
Domain	Sulfatase_N	ARSJ ARSB	3.13e-03	18	87	2	IPR000917
Domain	-	SACS MLH1	3.86e-03	20	87	2	3.30.565.10
Domain	HATPase_C	SACS MLH1	4.25e-03	21	87	2	IPR003594
Pathway	WP_NAD_METABOLISM	SIRT2 SIRT3 SIRT1	5.26e-05	16	66	3	M39541
Pathway	WP_NAD_BIOSYNTHETIC_PATHWAYS	SIRT2 SIRT3 SIRT1	1.42e-04	22	66	3	M39704
Pathway	WP_NAD_METABOLISM_IN_ONCOGENEINDUCED_SENESCENCE_AND_MITOCHONDRIAL_DYSFUNCTIONASSOCIATED_SENESCENCE	SIRT2 SIRT3 SIRT1	1.62e-04	23	66	3	M40059
Pathway	PID_HDAC_CLASSIII_PATHWAY	SIRT2 SIRT3 SIRT1	2.36e-04	26	66	3	M32
Pathway	REACTOME_REGULATION_OF_FOXO_TRANSCRIPTIONAL_ACTIVITY_BY_ACETYLATION	SIRT3 SIRT1	3.20e-04	6	66	2	MM15660
Pubmed	Developmental epigenetic modification regulates stochastic expression of clustered protocadherin genes, generating single neuron diversity.	PCDHA8 PCDHA6 PCDHA3 PCDHA2 PCDHA1 DNMT3B	2.86e-11	24	88	6	24698270
Pubmed	Monoallelic yet combinatorial expression of variable exons of the protocadherin-alpha gene cluster in single neurons.	PCDHA8 PCDHA6 PCDHA3 PCDHA2 PCDHA1	2.72e-10	15	88	5	15640798
Pubmed	Alpha protocadherins and Pyk2 kinase regulate cortical neuron migration and cytoskeletal dynamics via Rac1 GTPase and WAVE complex in mice.	PCDHA8 PCDHA6 PCDHA3 PCDHA2 PCDHA1	5.58e-10	17	88	5	29911975
Pubmed	CNR/Pcdhalpha family in subplate neurons, and developing cortical connectivity.	PCDHA8 PCDHA6 PCDHA3 PCDHA2 PCDHA1	7.72e-10	18	88	5	15570159
Pubmed	Genomic organization of the family of CNR cadherin genes in mice and humans.	PCDHA8 PCDHA6 PCDHA3 PCDHA2 PCDHA1	7.72e-10	18	88	5	10662547
Pubmed	Interaction with protocadherin-gamma regulates the cell surface expression of protocadherin-alpha.	PCDHA8 PCDHA6 PCDHA3 PCDHA2 PCDHA1	8.68e-09	28	88	5	15347688
Pubmed	Sirtuin Inhibition Induces Apoptosis-like Changes in Platelets and Thrombocytopenia.	SIRT2 SIRT3 SIRT1	1.57e-08	3	88	3	25829495
Pubmed	Identification of 'erasers' for lysine crotonylated histone marks using a chemical proteomics approach.	SIRT2 SIRT3 SIRT1	1.57e-08	3	88	3	25369635
Pubmed	The DNA sequence and comparative analysis of human chromosome 5.	PCDHA8 PCDHA6 PCDHA3 PCDHA2 PCDHA1 CPLANE1	3.86e-08	75	88	6	15372022
Pubmed	SIRT1 regulates HIV transcription via Tat deacetylation.	SIRT2 SIRT3 SIRT1	6.25e-08	4	88	3	15719057
Pubmed	Altered levels of sirtuin genes (SIRT1, SIRT2, SIRT3 and SIRT6) and their target genes in adipose tissue from individual with obesity.	SIRT2 SIRT3 SIRT1	6.25e-08	4	88	3	30641770
Pubmed	Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity.	SIRT2 SIRT3 SIRT1	1.56e-07	5	88	3	10381378
Pubmed	Sirtuin functions in health and disease.	SIRT2 SIRT3 SIRT1	3.11e-07	6	88	3	17456799
Pubmed	Clustered gamma-protocadherins regulate cortical interneuron programmed cell death.	PCDHA8 PCDHA6 PCDHA3 PCDHA2 PCDHA1	3.49e-07	57	88	5	32633719
Pubmed	CTCF Governs the Identity and Migration of MGE-Derived Cortical Interneurons.	PCDHA8 PCDHA6 PCDHA3 PCDHA2 PCDHA1	3.81e-07	58	88	5	30377227
Pubmed	Epigenetic functions of smchd1 repress gene clusters on the inactive X chromosome and on autosomes.	SMC1A PCDHA8 PCDHA6 PCDHA1 DNMT3B	4.16e-07	59	88	5	23754746
Pubmed	Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins.	SIRT2 SIRT3 SIRT1	5.44e-07	7	88	3	16079181
Pubmed	Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins.	SIRT2 SIRT3 SIRT1	5.44e-07	7	88	3	10873683
Pubmed	Assessing sirtuin expression in endometrial carcinoma and non-neoplastic endometrium.	SIRT2 SIRT3 SIRT1	5.44e-07	7	88	3	26701732
Pubmed	Integration of β-catenin, sirtuin, and FOXO signaling protects from mutant huntingtin toxicity.	SIRT2 SIRT3 SIRT1	5.44e-07	7	88	3	22956852
Pubmed	Comparative DNA sequence analysis of mouse and human protocadherin gene clusters.	PCDHA8 PCDHA6 PCDHA3 PCDHA2 PCDHA1	8.50e-07	68	88	5	11230163
Pubmed	A striking organization of a large family of human neural cadherin-like cell adhesion genes.	PCDHA8 PCDHA6 PCDHA3 PCDHA2 PCDHA1	1.13e-06	72	88	5	10380929
Pubmed	Cadherin superfamily genes: functions, genomic organization, and neurologic diversity.	PCDHA8 PCDHA6 PCDHA3 PCDHA2 PCDHA1	1.30e-06	74	88	5	10817752
Pubmed	Sirt3 protects in vitro-fertilized mouse preimplantation embryos against oxidative stress-induced p53-mediated developmental arrest.	SIRT2 SIRT3 SIRT1	1.30e-06	9	88	3	20644252
Pubmed	Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members.	PCDHA8 PCDHA6 PCDHA3 PCDHA2 PCDHA1	1.58e-06	77	88	5	10835267
Pubmed	Acetylation-dependent regulation of MDM2 E3 ligase activity dictates its oncogenic function.	SIRT2 SIRT3 SIRT1	1.85e-06	10	88	3	28196907
Pubmed	Interplay between protein acetylation and ubiquitination controls MCL1 protein stability.	SIRT2 SIRT3 SIRT1	1.85e-06	10	88	3	34758305
Pubmed	Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes.	PCDHA8 PCDHA6 PCDHA3 PCDHA2 PCDHA1	1.91e-06	80	88	5	10716726
Pubmed	Cardioprotection by nicotinamide mononucleotide (NMN): Involvement of glycolysis and acidic pH.	SIRT3 SIRT1	6.33e-06	2	88	2	29958828
Pubmed	SIRT1-SIRT3 Axis Regulates Cellular Response to Oxidative Stress and Etoposide.	SIRT3 SIRT1	6.33e-06	2	88	2	27925196
Pubmed	Imbalance of Lysine Acetylation Contributes to the Pathogenesis of Parkinson's Disease.	SIRT3 SIRT1	6.33e-06	2	88	2	33003340
Pubmed	SIRT2 and SIRT3 expression correlates with redox imbalance and advanced clinical stage in patients with multiple myeloma.	SIRT2 SIRT3	6.33e-06	2	88	2	33861984
Pubmed	SIRT3 is required for liver regeneration but not for the beneficial effect of nicotinamide riboside.	SIRT3 SIRT1	6.33e-06	2	88	2	33690226
Pubmed	Rs2015 Polymorphism in miRNA Target Site of Sirtuin2 Gene Is Associated with the Risk of Parkinson's Disease in Chinese Han Population.	SIRT2 SIRT1	6.33e-06	2	88	2	31214610
Pubmed	Dynamics and necessity of SIRT1 for maternal-zygotic transition.	SIRT2 SIRT1	6.33e-06	2	88	2	39285243
Pubmed	Dietary fatty acids as nutritional modulators of sirtuins: a systematic review.	SIRT3 SIRT1	6.33e-06	2	88	2	32403131
Pubmed	Reduced gene expression of sirtuins and active AMPK levels in children and adolescents with obesity and insulin resistance.	SIRT2 SIRT1	6.33e-06	2	88	2	29150224
Pubmed	Cerebellar Predominant Increase in mRNA Expression Levels of Sirt1 and Sirt3 Isoforms in a Transgenic Mouse Model of Huntington's Disease.	SIRT3 SIRT1	6.33e-06	2	88	2	32524313
Pubmed	Seeding for sirtuins: microseed matrix seeding to obtain crystals of human Sirt3 and Sirt2 suitable for soaking.	SIRT2 SIRT3	6.33e-06	2	88	2	26625292
Pubmed	Obesity and aging diminish sirtuin 1 (SIRT1)-mediated deacetylation of SIRT3, leading to hyperacetylation and decreased activity and stability of SIRT3.	SIRT3 SIRT1	6.33e-06	2	88	2	28808064
Pubmed	Expression of sirtuin 1 and 2 is associated with poor prognosis in non-small cell lung cancer patients.	SIRT2 SIRT1	6.33e-06	2	88	2	25915617
Pubmed	Sirtuins 1 and 2 Are Universal Histone Deacetylases.	SIRT2 SIRT1	6.33e-06	2	88	2	26820517
Pubmed	Nicotinamide mononucleotide alters mitochondrial dynamics by SIRT3-dependent mechanism in male mice.	SIRT3 SIRT1	6.33e-06	2	88	2	30801823
Pubmed	Differential sirtuin expression patterns in amyotrophic lateral sclerosis (ALS) postmortem tissue: neuroprotective or neurotoxic properties of sirtuins in ALS?	SIRT2 SIRT1	6.33e-06	2	88	2	22796962
Pubmed	Dual Deletion of the Sirtuins SIRT2 and SIRT3 Impacts on Metabolism and Inflammatory Responses of Macrophages and Protects From Endotoxemia.	SIRT2 SIRT3	6.33e-06	2	88	2	31849939
Pubmed	The plasticizer BBP selectively inhibits epigenetic regulator sirtuins.	SIRT3 SIRT1	6.33e-06	2	88	2	26520405
Pubmed	Sirtuin 1 and Sirtuin 3 in Granulosa Cell Tumors.	SIRT3 SIRT1	6.33e-06	2	88	2	33669567
Pubmed	Reduced SIRT1 and SIRT3 and Lower Antioxidant Capacity of Seminal Plasma Is Associated with Shorter Sperm Telomere Length in Oligospermic Men.	SIRT3 SIRT1	6.33e-06	2	88	2	38255792
Pubmed	Resveratrol Induced Premature Senescence Is Associated with DNA Damage Mediated SIRT1 and SIRT2 Down-Regulation.	SIRT2 SIRT1	6.33e-06	2	88	2	25924011
Pubmed	Human SIRT2 and SIRT3 deacetylases function in DNA homologous recombinational repair.	SIRT2 SIRT3	6.33e-06	2	88	2	33624391
Pubmed	RTN4B-mediated suppression of Sirtuin 2 activity ameliorates β-amyloid pathology and cognitive impairment in Alzheimer's disease mouse model.	SIRT2 SIRT1	6.33e-06	2	88	2	32700357
Pubmed	Discovery of a potent small molecule SIRT1/2 inhibitor with anticancer effects.	SIRT2 SIRT1	6.33e-06	2	88	2	23900402
Pubmed	Cloning and characterization of two mouse genes with homology to the yeast Sir2 gene.	SIRT2 SIRT3	6.33e-06	2	88	2	11056054
Pubmed	Alterations of SIRT1/SIRT3 subcellular distribution in aging undermine cardiometabolic homeostasis during ischemia and reperfusion.	SIRT3 SIRT1	6.33e-06	2	88	2	37537789
Pubmed	Reduced SIRT1 and SIRT2 expression promotes adipogenesis of human visceral adipose stem cells and associates with accumulation of visceral fat in human obesity.	SIRT2 SIRT1	6.33e-06	2	88	2	31462690
Pubmed	SIRT1 and SIRT2 inhibition impairs pediatric soft tissue sarcoma growth.	SIRT2 SIRT1	6.33e-06	2	88	2	25341037
Pubmed	Altered cellular redox status, sirtuin abundance and clock gene expression in a mouse model of developmentally primed NASH.	SIRT3 SIRT1	6.33e-06	2	88	2	27040510
Pubmed	Tissue-specific deregulation of selected HDACs characterizes ALS progression in mouse models: pharmacological characterization of SIRT1 and SIRT2 pathways.	SIRT2 SIRT1	6.33e-06	2	88	2	24946089
Pubmed	SIRT1/2 orchestrate acquisition of DNA methylation and loss of histone H3 activating marks to prevent premature activation of inflammatory genes in macrophages.	SIRT2 SIRT1	6.33e-06	2	88	2	31799621
Pubmed	Sirtuins-mediators of maternal obesity-induced complications in offspring?	SIRT3 SIRT1	6.33e-06	2	88	2	26667041
Pubmed	SIRT1 activation with neuroheal is neuroprotective but SIRT2 inhibition with AK7 is detrimental for disconnected motoneurons.	SIRT2 SIRT1	6.33e-06	2	88	2	29748539
Pubmed	Intron-less processed Pcdhalpha genes in the central nervous system.	PCDHA8 PCDHA6	6.33e-06	2	88	2	14697259
Pubmed	Activation of AMPK/Sirt3 pathway by phloretin reduces mitochondrial ROS in vascular endothelium by increasing the activity of MnSOD via deacetylation.	SIRT3 SIRT1	6.33e-06	2	88	2	32195489
Pubmed	The modulation of SIRT1 and SIRT3 by natural compounds as a therapeutic target in doxorubicin-induced cardiotoxicity: A review.	SIRT3 SIRT1	6.33e-06	2	88	2	34747550
Pubmed	SIRT1 and SIRT3 deacetylate homologous substrates: AceCS1,2 and HMGCS1,2.	SIRT3 SIRT1	6.33e-06	2	88	2	21701047
Pubmed	4'-Bromo-resveratrol, a dual Sirtuin-1 and Sirtuin-3 inhibitor, inhibits melanoma cell growth through mitochondrial metabolic reprogramming.	SIRT3 SIRT1	6.33e-06	2	88	2	31292999
Pubmed	Sex differences in muscle SIRT1 and SIRT3 and exercise + weight loss effects on muscle sirtuins.	SIRT3 SIRT1	6.33e-06	2	88	2	36740765
Pubmed	Possible role of SIRT1 and SIRT3 in post-translational modifications in human breast milk during the neonatal period.	SIRT3 SIRT1	6.33e-06	2	88	2	35976439
Pubmed	Distinct role of Sirtuin 1 (SIRT1) and Sirtuin 2 (SIRT2) in inhibiting cargo-loading and release of extracellular vesicles.	SIRT2 SIRT1	6.33e-06	2	88	2	31882861
Pubmed	Essential role of SIRT1 signaling in the nucleus accumbens in cocaine and morphine action.	SIRT2 SIRT1	6.33e-06	2	88	2	24107942
Pubmed	Curcumin elevates sirtuin level but does not postpone in vitro senescence of human cells building the vasculature.	SIRT3 SIRT1	6.33e-06	2	88	2	27034011
Pubmed	Sirt6 regulates the proliferation of neural precursor cells and cortical neurogenesis in mice.	SIRT2 SIRT3 SIRT1	6.97e-06	15	88	3	38288355
Pubmed	Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.	GJB5 PCDHA8 PCDHA6 PCDHA3 PCDHA2 PCDHA1	1.00e-05	193	88	6	22589738
Pubmed	HDAC family: What are the cancer relevant targets?	SIRT2 SIRT3 SIRT1	1.24e-05	18	88	3	18824292
Pubmed	A Genome-Wide CRISPR Screen Identifies Genes Critical for Resistance to FLT3 Inhibitor AC220.	PCDHA8 PCDHA6 PCDHA3 PCDHA2 PCDHA1	1.35e-05	119	88	5	28625976
Pubmed	Clinicopathological significance of SIRT1 and p300/CBP expression in gastroesophageal junction (GEJ) cancer and the correlation with E-cadherin and MLH1.	MLH1 SIRT1	1.90e-05	3	88	2	24035280
Pubmed	Localization and Expression of Sirtuins 1, 2, 6 and Plasticity-Related Proteins in the Recovery Period after a Photothrombotic Stroke in Mice.	SIRT2 SIRT1	1.90e-05	3	88	2	32912518
Pubmed	Regulation of the mitogen-activated protein kinase kinase (MEK)-1 by NAD(+)-dependent deacetylases.	SIRT2 SIRT1	1.90e-05	3	88	2	24681949
Pubmed	Altered expression of SIRT gene family in head and neck squamous cell carcinoma.	SIRT2 SIRT1	1.90e-05	3	88	2	23475622
Pubmed	Activation of SIRT1 Enhances Epidermal Permeability Barrier Formation through Ceramide Synthase 2- and 3-Dependent Mechanisms.	CERS3 SIRT1	1.90e-05	3	88	2	31958434
Pubmed	Cross-talk between sirtuin and mammalian target of rapamycin complex 1 (mTORC1) signaling in the regulation of S6 kinase 1 (S6K1) phosphorylation.	SIRT2 SIRT1	1.90e-05	3	88	2	24652283
Pubmed	Two novel CNRs from the CNR gene cluster have molecular features distinct from those of CNR1 to 8.	PCDHA2 PCDHA1	1.90e-05	3	88	2	11401448
Pubmed	Pro-Inflammatory of PRDM1/SIRT2/NLRP3 Axis in Monosodium Urate-Induced Acute Gouty Arthritis.	SIRT2 PRDM1	1.90e-05	3	88	2	37385228
Pubmed	Histone deacetylase 1, Sirtuin 1, and Sirtuin 3 single-nucleotide polymorphisms and the risk of endometriosis in South Indian women.	SIRT3 SIRT1	1.90e-05	3	88	2	35980861
Pubmed	Sirtuins and renal diseases: relationship with aging and diabetic nephropathy.	SIRT3 SIRT1	1.90e-05	3	88	2	23075334
Pubmed	Expression of SIRT1, SIRT3 and SIRT6 Genes for Predicting Survival in Triple-Negative and Hormone Receptor-Positive Subtypes of Breast Cancer.	SIRT3 SIRT1	1.90e-05	3	88	2	32681437
Pubmed	Sirt1 induction confers resistance to etoposide-induced genotoxic apoptosis in thyroid cancers.	SIRT3 SIRT1	1.90e-05	3	88	2	25109285
Pubmed	Inhibition of sirtuins 1 and 2 impairs cell survival and migration and modulates the expression of P-glycoprotein and MRP3 in hepatocellular carcinoma cell lines.	SIRT2 SIRT1	1.90e-05	3	88	2	29545174
Pubmed	Differential Expression and Clinical Significance of DNA Methyltransferase 3B (DNMT3B), Phosphatase and Tensin Homolog (PTEN) and Human MutL Homologs 1 (hMLH1) in Endometrial Carcinomas.	MLH1 DNMT3B	1.90e-05	3	88	2	28220037
Pubmed	Adipose tissue and liver expression of SIRT1, 3, and 6 increase after extensive weight loss in morbid obesity.	SIRT3 SIRT1	1.90e-05	3	88	2	23928404
Pubmed	Localization of sirtuins (SIRT1-7) in the aged mouse inner ear.	SIRT3 SIRT1	1.90e-05	3	88	2	26472659
Pubmed	Are sirtuins markers of ovarian aging?	SIRT3 SIRT1	1.90e-05	3	88	2	26403315
Pubmed	Alterations in mitochondrial dynamics with age-related Sirtuin1/Sirtuin3 deficiency impair cardiomyocyte contractility.	SIRT3 SIRT1	1.90e-05	3	88	2	34216536
Pubmed	Melatonin and Sirtuins in Buccal Epithelium: Potential Biomarkers of Aging and Age-Related Pathologies.	SIRT3 SIRT1	1.90e-05	3	88	2	33143333
Pubmed	Differential expressions of SIRT1, SIRT3, and SIRT4 in peripheral blood mononuclear cells from patients with type 2 diabetic retinopathy.	SIRT3 SIRT1	1.90e-05	3	88	2	30572719
Pubmed	Altered sirtuin deacetylase gene expression in patients with a mood disorder.	SIRT2 SIRT1	1.90e-05	3	88	2	21349544
Pubmed	Sequential actions of SIRT1-RELB-SIRT3 coordinate nuclear-mitochondrial communication during immunometabolic adaptation to acute inflammation and sepsis.	SIRT3 SIRT1	1.90e-05	3	88	2	25404738
Pubmed	SIRT2 regulates NF-κB dependent gene expression through deacetylation of p65 Lys310.	SIRT2 SIRT1	1.90e-05	3	88	2	21081649
Pubmed	Nucleus distribution of cathepsin B in senescent microglia promotes brain aging through degradation of sirtuins.	SIRT2 SIRT3	1.90e-05	3	88	2	33049518
Pubmed	Expression/localization patterns of sirtuins (SIRT1, SIRT2, and SIRT7) during progression of cervical cancer and effects of sirtuin inhibitors on growth of cervical cancer cells.	SIRT2 SIRT1	1.90e-05	3	88	2	25794641
Interaction	PCDHA10 interactions	PCDHA8 PCDHA6 PCDHA3 PCDHA2	2.13e-06	22	86	4	int:PCDHA10
Interaction	PCDHA8 interactions	PCDHA8 PCDHA6 PCDHA3 PCDHA2 PCDHA1	3.70e-06	55	86	5	int:PCDHA8
Interaction	PCDHA6 interactions	PCDHA8 PCDHA6 PCDHA3	6.19e-06	9	86	3	int:PCDHA6
Interaction	PCDHA1 interactions	PCDHA8 PCDHA3 PCDHA1	6.19e-06	9	86	3	int:PCDHA1
Interaction	PCDHA3 interactions	PCDHA8 PCDHA6 PCDHA3 PCDHA1	1.30e-05	34	86	4	int:PCDHA3
Cytoband	5q31	PCDHA8 PCDHA6 PCDHA3 PCDHA2 PCDHA1	3.00e-06	115	88	5	5q31
Cytoband	Ensembl 112 genes in cytogenetic band chr5q31	PCDHA8 PCDHA6 PCDHA3 PCDHA2 PCDHA1	2.81e-04	298	88	5	chr5q31
Cytoband	13q14.13	NEK3 COG3	8.95e-04	23	88	2	13q14.13
Cytoband	3p14.3	DNAH12 A4GNT	1.53e-03	30	88	2	3p14.3
Cytoband	20q11.22	ITCH RBM39	2.32e-03	37	88	2	20q11.22
GeneFamily	Sirtuins	SIRT2 SIRT3 SIRT1	1.76e-06	7	68	3	938
GeneFamily	Clustered protocadherins	PCDHA8 PCDHA6 PCDHA3 PCDHA2 PCDHA1	4.16e-06	64	68	5	20
GeneFamily	Fatty acid hydroxylase domain containing	SC5D FA2H	2.07e-04	6	68	2	552
GeneFamily	Sulfatases	ARSJ ARSB	2.05e-03	18	68	2	410
CoexpressionAtlas	dev gonad_e11.5_F_PrimGermCell_Oct_k-means-cluster#1_top-relative-expression-ranked_100	ENPP3 PRDM1	1.55e-05	2	84	2	gudmap_dev gonad_e11.5_F_PrimGermCell_Oct_k1_100
CoexpressionAtlas	dev gonad_e12.5_M_GermCellTestis_Oct_k-means-cluster#1_top-relative-expression-ranked_100	ENPP3 PRDM1	1.55e-05	2	84	2	gudmap_dev gonad_e12.5_M_GermCellTestis_Oct_k1_100
CoexpressionAtlas	dev gonad_e12.5_F_GermCellOvary_Oct_k-means-cluster#3_top-relative-expression-ranked_100	ENPP3 PRDM1	4.63e-05	3	84	2	gudmap_dev gonad_e12.5_F_GermCellOvary_Oct_k3_100
CoexpressionAtlas	dev gonad_e12.5_F_DevVasOvary_Flk_k-means-cluster#2_top-relative-expression-ranked_200	ENPP3 PRDM1	4.63e-05	3	84	2	gudmap_dev gonad_e12.5_F_gudmap_devVasOvary_Flk_k2_200
CoexpressionAtlas	dev gonad_e11.5_M_PrimGermCell_Oct_k-means-cluster#3_top-relative-expression-ranked_100	ENPP3 PRDM1	4.63e-05	3	84	2	gudmap_dev gonad_e11.5_M_PrimGermCell_Oct_k3_100
CoexpressionAtlas	dev gonad_e13.5_F_DevVascOvary_Flk_k-means-cluster#1_top-relative-expression-ranked_100	ENPP3 PRDM1	4.63e-05	3	84	2	gudmap_dev gonad_e13.5_F_gudmap_devVascOvary_Flk_k1_100
CoexpressionAtlas	dev gonad_e13.5_F_DevVascOvary_Flk_k-means-cluster#4_top-relative-expression-ranked_200	ENPP3 PRDM1	4.63e-05	3	84	2	gudmap_dev gonad_e13.5_F_gudmap_devVascOvary_Flk_k4_200
CoexpressionAtlas	dev gonad_e13.5_M_DevVasTestis_Flk_k-means-cluster#2_top-relative-expression-ranked_100	ENPP3 PRDM1	4.63e-05	3	84	2	gudmap_dev gonad_e13.5_M_gudmap_devVasTestis_Flk_k2_100
CoexpressionAtlas	dev gonad_e12.5_F_DevVasOvary_Flk_k-means-cluster#2_top-relative-expression-ranked_100	ENPP3 PRDM1	4.63e-05	3	84	2	gudmap_dev gonad_e12.5_F_gudmap_devVasOvary_Flk_k2_100
CoexpressionAtlas	dev gonad_e11.5_F_PrimGermCell_Oct_k-means-cluster#2_top-relative-expression-ranked_200	ENPP3 PRDM1	4.63e-05	3	84	2	gudmap_dev gonad_e11.5_F_PrimGermCell_Oct_k2_200
CoexpressionAtlas	dev gonad_e11.5_M_PrimGermCell_Oct_k-means-cluster#1_top-relative-expression-ranked_200	ENPP3 PRDM1	4.63e-05	3	84	2	gudmap_dev gonad_e11.5_M_PrimGermCell_Oct_k1_200
CoexpressionAtlas	dev gonad_e12.5_M_DevVasTestis_Flk_k-means-cluster#4_top-relative-expression-ranked_100	ENPP3 PRDM1	9.23e-05	4	84	2	gudmap_dev gonad_e12.5_M_gudmap_devVasTestis_Flk_k4_100
CoexpressionAtlas	DevelopingGonad_P2_epididymis_emap-30199_k-means-cluster#2_top-relative-expression-ranked_100	RBM39 ITIH5	9.23e-05	4	84	2	gudmap_developingGonad_P2_epididymis_100_k2
CoexpressionAtlas	dev gonad_e11.5_F_PrimGermCell_Oct_k-means-cluster#4_top-relative-expression-ranked_500	ENPP3 PRDM1	2.30e-04	6	84	2	gudmap_dev gonad_e11.5_F_PrimGermCell_Oct_k4_500
CoexpressionAtlas	DevelopingGonad_e18.5_epididymis_emap-13166_top-relative-expression-ranked_1000	ZNF462 FMO1 ITCH ARSJ CLMN SMC1A PDZK1 CPLANE1 CDC14A RBM39 ITIH5	3.04e-04	799	84	11	gudmap_developingGonad_e18.5_epididymis_1000
CoexpressionAtlas	DevelopingGonad_P2_ovary_emap-30224_k-means-cluster#5_top-relative-expression-ranked_1000	FMO1 ITCH CPLANE1 CDC14A RBM39	3.34e-04	151	84	5	gudmap_developingGonad_P2_ovary_1000_k5
ToppCell	TCGA-Colorectal-Primary_Tumor-Colorectal_Adenocarcinoma-Mucinous_Colon_Adenocarcinoma\|TCGA-Colorectal / Sample_Type by Project: Shred V9	ENTPD7 ARSB KYNU AQP9 NLRC4	1.86e-05	164	88	5	3c15e9b8403b03d67f6ecd7861dc19f1261e3244
ToppCell	droplet-Kidney-nan-3m-Epithelial-brush_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FMO1 PDZK1 HSD17B2 ACE ITIH5	2.21e-05	170	88	5	dd48fd3c5c67eb71183981f42975a538f12077c3
ToppCell	droplet-Lung-LUNG-1m-Lymphocytic-plasma_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RPGRIP1L DERL3 TRAM2 DNMT3B PRDM1	2.68e-05	177	88	5	c6812679aa6522d03bd29144e71c5fae6a92325e
ToppCell	droplet-Lung-LUNG-1m-Lymphocytic-Plasma_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RPGRIP1L DERL3 TRAM2 DNMT3B PRDM1	2.68e-05	177	88	5	ff97398d2adb83063b7c53a264bfae86ea7ea304
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Intercalated_Cell_Type_B\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PLEK2 ARSJ SACS PIP5K1B ITIH5	2.75e-05	178	88	5	51d2188406f04329311b2efd1108fc36617a860e
ToppCell	CF-Myeloid-Neutrophil\|CF / Disease state, Lineage and Cell class	NPL PPCDC RALGAPA2 AQP9 CXCR1	3.14e-05	183	88	5	da43827952e6fdee2ce94648c316182f272b321c
ToppCell	COVID-19-kidney-PCT-S1\|kidney / Disease (COVID-19 only), tissue and cell type	ZNF462 FMO1 ABCA13 PDZK1 FLRT3	3.22e-05	184	88	5	51ed1ebfdef45149541917c66cbacad87072e51f
ToppCell	E18.5-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DDX59 FMO1 ITCH MLH1 ACE	3.48e-05	187	88	5	3699d5e71d779da922920aa3160895db187bf81b
ToppCell	E18.5-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1-CAP1_mature\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DDX59 FMO1 ITCH MLH1 ACE	3.48e-05	187	88	5	033ba52c0c2f9978784947098fa697368ae44834
ToppCell	COVID-19-kidney-CD-IC-B\|kidney / Disease (COVID-19 only), tissue and cell type	ARSJ SACS PIP5K1B GALNT7 ITIH5	3.48e-05	187	88	5	ce05b89860573fe0356102e2998d1ef6d1968034
ToppCell	wk_15-18-Hematologic-Myeloid-Basophil\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	ENTPD7 FASTKD3 RALGAPA2 CDC14A CXCR1	3.57e-05	188	88	5	3638d85452de15a060146628fbbad9d2a36feb13
ToppCell	15-Distal-RBC\|Distal / Age, Tissue, Lineage and Cell class	NPL PDZK1 HSD17B2 HBM KYNU	3.57e-05	188	88	5	c68ccb1c5c21d13ddac09b16e7d466f0530bbda5
ToppCell	15-Distal-RBC-RBC\|Distal / Age, Tissue, Lineage and Cell class	NPL PDZK1 HSD17B2 HBM KYNU	3.57e-05	188	88	5	2534684e4932c1255c24a26ca2277ac7af0a118b
ToppCell	moderate-Epithelial-Ionocyte\|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	SIRT2 FMO1 ARSJ SC5D ITIH5	3.66e-05	189	88	5	6011b747e27d61d222380a7bffdd921a68e9b657
ToppCell	Adult-Immune-alveolar_macrophage_(MARCO_positive)-D175\|Adult / Lineage, Cell type, age group and donor	NPL ARSB ABHD12 KYNU AQP9	3.95e-05	192	88	5	733491e932350e3c216a626cc49c3cd3fe970a82
ToppCell	TCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma-Acinar_Adenocarcinoma-6\|TCGA-Prostate / Sample_Type by Project: Shred V9	ENTPD7 SMC1A HEATR5A CPLANE1 SMCR8	4.05e-05	193	88	5	abd71b2cf667ef2b1c4d88acd0c1dd19a12ff659
ToppCell	moderate-Epithelial-FOXN4+\|moderate / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	RPGRIP1L ABCA13 CLMN WDR90 CPLANE1	4.15e-05	194	88	5	5dffa578149104dda33774361e9e77b227b5f1ce
ToppCell	Children_(3_yrs)-Immune-alveolar_macrophage_(MARCO_positive)-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	NPL ARSB ABHD12 KYNU AQP9	4.25e-05	195	88	5	9d649ac7d2af313481069c95349efc0c68449e2b
ToppCell	3'-Airway_Nasal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Multiciliated_(nasal)-Multiciliated_(nasal)_L.0.3.1.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DNAH12 ABCA13 CLMN WDR90 CPLANE1	4.25e-05	195	88	5	79dc031258579ea328181dda33710dd897f1064a
ToppCell	severe-low-quality_cells\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	ENPP3 ZFC3H1 CDC14A RBM39 PRDM1	4.46e-05	197	88	5	57ebd552f10d6278623b52a3d484d4b91ae1d028
ToppCell	3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	RPGRIP1L DNAH12 MPDZ WDR90 CPLANE1	4.46e-05	197	88	5	74a2c6cb8fcfe53dd9a2b36492a16c58f38e51c9
Drug	polymarcine	SIRT2 SIRT3 SIRT1	6.57e-06	10	88	3	ctd:C008971
Drug	formylglycine	NPC1 ARSJ ARSB ENPP3	7.82e-06	33	88	4	CID000075606
Drug	4-nitrocatechol	NPC1 ARSJ ARSB ENPP3	7.82e-06	33	88	4	CID003505109
Drug	7-dehydrocholesterol	NPC1 NPL SC5D TMBIM4 HSD17B2	1.38e-05	79	88	5	CID000000172
Drug	salvianolic acid	SIRT3 SIRT1	1.48e-05	2	88	2	ctd:C568740
Disease	1,5 anhydroglucitol measurement	PCDHA8 PCDHA6 PCDHA3 PCDHA2 PCDHA1	2.10e-08	29	86	5	EFO_0008009
Disease	neutrophil count, basophil count	NPC1 PCDHA8 PCDHA6 PCDHA3 PCDHA2 PCDHA1 CXCR1	4.27e-06	224	86	7	EFO_0004833, EFO_0005090
Disease	post-traumatic stress disorder symptom measurement	PCDHA8 PCDHA6 PCDHA3 PCDHA2 PCDHA1	4.28e-06	82	86	5	EFO_0008535
Disease	visceral adipose tissue measurement, body mass index	PCDHA8 PCDHA6 PCDHA3 PCDHA2 PCDHA1	5.72e-06	87	86	5	EFO_0004340, EFO_0004765
Disease	post-traumatic stress disorder	PCDHA8 PCDHA6 PCDHA3 PCDHA2 PCDHA1	3.18e-04	202	86	5	EFO_0001358
Disease	Polydactyly	DDX59 RPGRIP1L SC5D CPLANE1	3.88e-04	117	86	4	C0152427
Disease	Disorder of eye	RPGRIP1L CLN5 OPA3 CPLANE1 ABHD12	3.97e-04	212	86	5	C0015397
Disease	Alzheimer disease, gastroesophageal reflux disease	DNAH12 PCDHA3 PCDHA2 PCDHA1 ACE	5.52e-04	228	86	5	EFO_0003948, MONDO_0004975
Disease	neutrophil count	NPC1 FMO1 CLK2 PPCDC PCDHA8 PCDHA6 PCDHA3 PCDHA2 PCDHA1 CDC14A SIRT1 CXCR1	6.57e-04	1382	86	12	EFO_0004833
Disease	Alcohol abuse	CDK20 MPDZ SIRT1	1.00e-03	67	86	3	C0085762
Disease	osteoporosis (implicated_via_orthology)	ACE SIRT1	1.39e-03	19	86	2	DOID:11476 (implicated_via_orthology)
Disease	Familial aplasia of the vermis	RPGRIP1L CPLANE1	1.54e-03	20	86	2	cv:C0431399
Disease	blood urea nitrogen measurement	ZNF462 PIP5K1B SENP2 WDR90 CDC14A SIRT1	2.09e-03	452	86	6	EFO_0004741
Disease	chronic myeloid leukemia (is_marker_for)	ACE DNMT3B	2.81e-03	27	86	2	DOID:8552 (is_marker_for)

Protein segments in the cluster

Peptide	Gene	Start	Entry
HIFATYPAPYLSLAN	AQP9	146	O43315
VSFPPQRYHYFLVLD	ERI3	136	O43414
KALLHQYFFTAPLPA	CDK20	281	Q8IZL9
LFFEFYHLLNYSRPK	DNMT3B	671	Q9UBC3
KFHIPSSVPYIRYFV	ACE	1116	P12821
LHAPEAYFPYFKKHN	CDC14A	206	Q9UNH5
FDFLKDNNYLPYPIH	CLK2	251	P49760
SPVFYPVQYFAHIKE	FAT4	686	Q6V0I7
YHNSLDEFPTNLPKY	FLRT3	91	Q9NZU0
NISFLHPQRFYPISY	A4GNT	251	Q9UNA3
LHSPNKDFYALYPTL	ABCA13	2431	Q86UQ4
LSPFQLYFNPHLVFR	DERL3	36	Q96Q80
VKYYPPNGTFSLHYF	ATP4B	216	P51164
PAVFYNQYFKHPKCV	C5orf64	71	Q2M2E5
ITAAYVPLPTYHNLF	RBM39	501	Q14498
PHVPFKLVSTFKNYY	PCDHA2	391	Q9Y5H9
PHVPFKLVSTFKNYY	PCDHA6	391	Q9UN73
AHFSPFLYYQSQELP	PDZK1	331	Q5T2W1
EAKSHPFSVIYRYFP	ABHD12	281	Q8N2K0
LFSPPQKYQLLVYHA	ANAPC7	36	Q9UJX3
PHVPFKLVSTFKNYY	PCDHA8	391	Q9Y5H6
PHVPFKLVSTFKNYY	PCDHA3	391	Q9Y5H8
LSSQLYPPVYYFLSH	OR8D2	51	Q9GZM6
LPYFSFHLYVALSAQ	GPR61	301	Q9BZJ8
HYSLADLLKYNFYLP	HHATL	201	Q9HCP6
RHKYPLNLYLLFGFT	TMBIM4	91	Q9HC24
KDLYHTPSFLNFYPL	NLRC4	106	Q9NPP4
FHFPYDYPNLRTAQL	ENTPD7	491	Q9NQZ7
ASHLQPHPYVVYKFF	RPGRIP1L	806	Q68CZ1
LNGYFVHYFAPKDLP	ITIH5	276	Q86UX2
YPLSKNFPYSLEHLQ	LRR1	146	Q96L50
ASHNPTKPIFLYIAY	ARSJ	251	Q5FYB0
PLNASYVYKEHPFIL	DDX59	161	Q5T1V6
FFKTYICLPPAQLYH	OPA3	36	Q9H6K4
YIHFLFPPFMNPFIY	OR51B6	276	Q9H340
HHYPDFRFKTYAPLA	PIP5K1B	76	O14986
NLYIVENPHYKFSPS	DNAH12	2731	Q6ZR08
LFTLFRKYYLPHLFP	RALGAPA2	241	Q2PPJ7
RKYYLPHLFPSFTKL	RALGAPA2	246	Q2PPJ7
PLPSHYSYELQFLVK	NEK3	221	P51956
PHVPFKLVSTFKNYY	PCDHA1	391	Q9Y5I3
FKSISQYLHAGPPVY	NPC1	876	O15118
FLFHMKPPSDSYYLI	FA2H	236	Q7L5A8
PASYINPDHLKYFRF	ITCH	626	Q96J02
PMYHLEPFFSYIFLN	CERS3	291	Q8IU89
YNQPEPVKSFLFYHS	IL36A	96	Q9UHA7
KTYQLLHSIFQYPNP	HEATR5A	1871	Q86XA9
SFYPAPAGNTHLYLL	CPLANE1	2186	Q9H799
FYLADKNITHGFLYP	ENPP3	681	O14638
ISSHPNFKDYPIYLL	COG3	236	Q96JB2
QYLTFKPQTFTYHDP	GALNT7	111	Q86SF2
SLYKYIFPAHLQKPT	FMO1	351	Q01740
DTAVLFPHYLGFPYK	REXO1L1P	601	Q8IX06
FPHYLGFPYKRSLRN	REXO1L1P	606	Q8IX06
NLSLPFFLFRQAYHP	CXCR1	166	P25024
QLYLQIHSKFPPSLY	C1orf112	276	Q9NSG2
RLQFYHKHSVPVYFP	ARSB	501	P15848
SNEHLLKTFSYFPYP	HOMEZ	66	Q8IX15
RLFTVYPSTKVYFPH	HBM	31	Q6B0K9
LYVFHSFYPKYILPP	GJB5	146	O95377
QHAILAKSPFAYYTP	HSD17B2	326	P37059
FHLNFEAAPYLYQLP	SACS	2361	Q9NZJ4
FYRKLYGLLDPSVFH	NOC4L	326	Q9BVI4
ILPKVFHYYGPALEF	MTBP	291	Q96DY7
VAAAAPALPFYYYHI	NPL	131	Q9BXD5
KTIYVFLHPMAFPYN	TAS2R60	76	P59551
GYPALHVFSTFFYPK	SENP2	431	Q9HC62
RHFTFTLYLETPKPY	PSG9	136	Q00887
KLENVLFTHFNYFPP	FASTKD3	431	Q14CZ7
LFTHFNYFPPKSLLK	FASTKD3	436	Q14CZ7
QYLFLPPNRYIFHGA	SIRT1	641	Q96EB6
HLPYPEAIFEISYFK	SIRT2	111	Q8IXJ6
ISYFKKHPEPFFALA	SIRT2	121	Q8IXJ6
FHNPKPFFTLAKELY	SIRT3	186	Q9NTG7
AFIPSYNAHYPKFLL	PRDM1	401	O75626
AAYLPKNTHPFLYLS	MLH1	281	P40692
LKFIRQYPFAHPAIY	SMCR8	711	Q8TEV9
HPLATSHQQYFYKIP	STEAP1	96	Q9UHE8
LFYFPHYEVPLAAVL	CLMN	726	Q96JQ2
FYYPFKPHLPTKEFL	CLN5	291	O75503
FPSLIYPLQVYQLHF	LINC01619	86	G3V211
AKHFYSPQDIPVTLY	PPCDC	56	Q96CD2
LRKDPAFLHYYDPSK	PLEK2	271	Q9NYT0
YLYVLFRPLPSKHFV	WDR90	71	Q96KV7
PYFAAAYTPYHQKLA	VGLL2	16	Q8N8G2
LPSLLHNLYPKYNFS	MPDZ	1251	O75970
SFLYGKNYSQRPLFH	SPDYE4	181	A6NLX3
YPHVHLPFQVKFFYL	TRAM2	151	Q15035
LFAIHSYKPAPFFVL	SMC1A	1141	Q14683
HPYIKFSFRYILDPN	ZNF462	866	Q96JM2
IDGFLQSLPYHIYPF	SC5D	171	O75845
HIYPFIFPLHKVVYL	SC5D	181	O75845
PYKYPESVKSFNHFT	ZNF329	146	Q86UD4
YHSPLLVFKSYRFSP	ZFC3H1	1146	O60293
APVPLYNSFHDVYKF	KYNU	436	Q16719