Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionacetylcholine-gated monoatomic cation-selective channel activity

CHRNA2 CHRNA5 CHRNB1 CHRNB2 CHRNB3

2.84e-08171115GO:0022848
GeneOntologyMolecularFunctionacetylcholine receptor activity

CHRNA2 CHRNA5 CHRNB1 CHRNB2 CHRNB3

1.51e-07231115GO:0015464
GeneOntologyMolecularFunctionacetylcholine binding

CHRNA5 CHRNB1 CHRNB2 CHRNB3

6.22e-07131114GO:0042166
GeneOntologyMolecularFunctionexcitatory extracellular ligand-gated monoatomic ion channel activity

CHRNA2 CHRNA5 CHRNB1 CHRNB2 CHRNB3

3.94e-06431115GO:0005231
GeneOntologyMolecularFunctiontransmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

CHRNA2 CHRNA5 CHRNB1 CHRNB2 CHRNB3

1.61e-05571115GO:1904315
GeneOntologyMolecularFunctionneurotransmitter receptor activity involved in regulation of postsynaptic membrane potential

CHRNA2 CHRNA5 CHRNB1 CHRNB2 CHRNB3

2.08e-05601115GO:0099529
GeneOntologyMolecularFunctiontransmitter-gated channel activity

CHRNA2 CHRNA5 CHRNB1 CHRNB2 CHRNB3

3.07e-05651115GO:0022835
GeneOntologyMolecularFunctiontransmitter-gated monoatomic ion channel activity

CHRNA2 CHRNA5 CHRNB1 CHRNB2 CHRNB3

3.07e-05651115GO:0022824
GeneOntologyMolecularFunctionpostsynaptic neurotransmitter receptor activity

CHRNA2 CHRNA5 CHRNB1 CHRNB2 CHRNB3

6.14e-05751115GO:0098960
GeneOntologyMolecularFunctionextracellular ligand-gated monoatomic ion channel activity

CHRNA2 CHRNA5 CHRNB1 CHRNB2 CHRNB3

6.97e-05771115GO:0005230
GeneOntologyMolecularFunctioncis-regulatory region sequence-specific DNA binding

ZNF136 ZBTB20 ZNF212 MAZ ZNF362 ZNF699 ZNF883 ZNF850 ZKSCAN5 ZNF774 ZNF691 HIVEP3 ZNF594 NFIC ZNF565 ZNF433 NOTCH2 ZNF572

2.18e-04127111118GO:0000987
GeneOntologyMolecularFunctionneurotransmitter receptor activity

CHRNA2 CHRNA5 CHRNB1 CHRNB2 CHRNB3

2.40e-041001115GO:0030594
GeneOntologyMolecularFunctionDNA-binding transcription factor activity, RNA polymerase II-specific

ZNF136 ZBTB20 ZNF177 ZNF212 MAZ ZNF699 ZNF883 ZNF850 ZKSCAN5 ZNF774 HIVEP3 ZNF594 NFIC ZNF398 ZNF565 ZBTB18 ZNF433 NOTCH2 ZNF572

2.74e-04141211119GO:0000981
GeneOntologyMolecularFunctionRNA polymerase II transcription regulatory region sequence-specific DNA binding

ZNF136 ZBTB20 ZNF177 ZNF212 MAZ ZNF362 ZNF699 ZNF883 ZNF850 ZKSCAN5 ZNF774 ZNF691 HIVEP3 ZNF594 NFIC ZNF398 ZNF565 ZNF433 ZNF572

4.13e-04145911119GO:0000977
GeneOntologyMolecularFunctionpeptidyltransferase activity

GGT2P GGT1

4.53e-0461112GO:0000048
GeneOntologyMolecularFunctionleukotriene-C(4) hydrolase

GGT2P GGT1

4.53e-0461112GO:0002951
GeneOntologyMolecularFunctionRNA polymerase II cis-regulatory region sequence-specific DNA binding

ZNF136 ZBTB20 ZNF212 MAZ ZNF362 ZNF699 ZNF883 ZNF850 ZKSCAN5 ZNF774 ZNF691 HIVEP3 ZNF594 NFIC ZNF565 ZNF433 ZNF572

5.00e-04124411117GO:0000978
GeneOntologyMolecularFunctionleukotriene C4 gamma-glutamyl transferase activity

GGT2P GGT1

8.39e-0481112GO:0103068
GeneOntologyMolecularFunctionglutathione hydrolase activity

GGT2P GGT1

1.07e-0391112GO:0036374
GeneOntologyMolecularFunctionligand-gated monoatomic cation channel activity

CHRNA2 CHRNA5 CHRNB1 CHRNB2 CHRNB3

1.11e-031401115GO:0099094
GeneOntologyMolecularFunctionmonoatomic cation channel activity

PKDREJ CHRNA2 CHRNA5 CHRNB1 CHRNB2 CHRNB3 CACNA2D4

3.07e-033431117GO:0005261
GeneOntologyMolecularFunctionomega peptidase activity

GGT2P GGT1

3.49e-03161112GO:0008242
GeneOntologyBiologicalProcessacetylcholine receptor signaling pathway

SORBS1 CHRNA2 CHRNA5 CHRNB1 CHRNB2 CHRNB3

2.81e-07511096GO:0095500
GeneOntologyBiologicalProcesscellular response to acetylcholine

SORBS1 CHRNA2 CHRNA5 CHRNB1 CHRNB2 CHRNB3

3.56e-07531096GO:1905145
GeneOntologyBiologicalProcessresponse to acetylcholine

SORBS1 CHRNA2 CHRNA5 CHRNB1 CHRNB2 CHRNB3

4.97e-07561096GO:1905144
GeneOntologyBiologicalProcesspostsynaptic signal transduction

SORBS1 CHRNA2 CHRNA5 CHRNB1 CHRNB2 CHRNB3

1.73e-06691096GO:0098926
GeneOntologyBiologicalProcesssynaptic transmission, cholinergic

CHRNA2 CHRNA5 CHRNB1 CHRNB2 CHRNB3

3.46e-06441095GO:0007271
GeneOntologyBiologicalProcessresponse to nicotine

CHRNA2 CHRNA5 CHRNB1 CHRNB2 CHRNB3

1.38e-05581095GO:0035094
GeneOntologyBiologicalProcessbehavioral response to nicotine

CHRNA5 CHRNB1 CHRNB2

2.30e-05111093GO:0035095
GeneOntologyBiologicalProcessexcitatory postsynaptic potential

CHRNA2 CHRNA5 CHRNB1 CHRNB2 CHRNB3 NLGN2

6.65e-051301096GO:0060079
GeneOntologyBiologicalProcesschemical synaptic transmission, postsynaptic

CHRNA2 CHRNA5 CHRNB1 CHRNB2 CHRNB3 NLGN2

1.31e-041471096GO:0099565
GeneOntologyCellularComponentacetylcholine-gated channel complex

CHRNA2 CHRNA5 CHRNB1 CHRNB2 CHRNB3

3.42e-08181135GO:0005892
GeneOntologyCellularComponentdopaminergic synapse

CHRNA5 CHRNB2 CHRNB3 NLGN2

5.49e-06221134GO:0098691
GeneOntologyCellularComponentpostsynaptic membrane

CLSTN2 CHRNA2 CHRNA5 CHRNB1 CHRNB2 CHRNB3 EFNB2 LZTS1 NLGN2

3.56e-044051139GO:0045211
DomainZINC_FINGER_C2H2_2

ZNF136 ZBTB20 ZNF177 ZNF212 MAZ ZNF362 ZNF699 ZNF883 ZNF850 REPIN1 ZKSCAN5 ZNF774 ZNF691 HIVEP3 ZNF594 ZNF804B ZNF398 ZNF565 ZNF839 ZBTB18 ZNF433 ZNF572

8.49e-1077511122PS50157
DomainZINC_FINGER_C2H2_1

ZNF136 ZBTB20 ZNF177 ZNF212 MAZ ZNF362 ZNF699 ZNF883 ZNF850 REPIN1 ZKSCAN5 ZNF774 ZNF691 HIVEP3 ZNF594 ZNF804B ZNF398 ZNF565 ZNF839 ZBTB18 ZNF433 ZNF572

8.90e-1077711122PS00028
DomainZnf_C2H2-like

ZNF136 ZBTB20 ZNF177 ZNF212 MAZ ZNF362 ZNF699 ZNF883 ZNF850 REPIN1 ZKSCAN5 ZNF774 ZNF691 HIVEP3 ZNF594 ZNF804B ZNF398 ZNF565 ZNF839 ZBTB18 ZNF433 ZNF572

1.39e-0979611122IPR015880
DomainZnf_C2H2

ZNF136 ZBTB20 ZNF177 ZNF212 MAZ ZNF362 ZNF699 ZNF883 ZNF850 REPIN1 ZKSCAN5 ZNF774 ZNF691 HIVEP3 ZNF594 ZNF804B ZNF398 ZNF565 ZNF839 ZBTB18 ZNF433 ZNF572

1.72e-0980511122IPR007087
DomainZnF_C2H2

ZNF136 ZBTB20 ZNF177 ZNF212 MAZ ZNF362 ZNF699 ZNF883 ZNF850 REPIN1 ZKSCAN5 ZNF774 ZNF691 HIVEP3 ZNF594 ZNF804B ZNF398 ZNF565 ZNF839 ZBTB18 ZNF433 ZNF572

1.84e-0980811122SM00355
Domainzf-C2H2

ZNF136 ZBTB20 ZNF177 ZNF212 MAZ ZNF362 ZNF699 ZNF883 ZNF850 REPIN1 ZKSCAN5 ZNF774 ZNF691 HIVEP3 ZNF594 ZNF398 ZNF565 ZBTB18 ZNF433 ZNF572

4.19e-0969311120PF00096
DomainZnf_C2H2/integrase_DNA-bd

ZNF136 ZBTB20 ZNF177 ZNF212 MAZ ZNF362 ZNF699 ZNF883 ZNF850 REPIN1 ZKSCAN5 ZNF774 ZNF691 HIVEP3 ZNF594 ZNF398 ZNF565 ZBTB18 ZNF433 ZNF572

4.30e-0969411120IPR013087
Domain-

ZNF136 ZBTB20 ZNF212 MAZ ZNF362 ZNF699 ZNF883 ZNF850 REPIN1 ZKSCAN5 ZNF774 ZNF691 HIVEP3 ZNF594 ZNF398 ZNF565 ZBTB18 ZNF433 ZNF572

1.77e-08679111193.30.160.60
DomainNicotinic_acetylcholine_rcpt

CHRNA2 CHRNA5 CHRNB1 CHRNB2 CHRNB3

2.81e-08161115IPR002394
Domain-

CHRNA2 CHRNA5 CHRNB1 CHRNB2 CHRNB3

2.09e-072311151.20.120.370
DomainAcetylcholine_rcpt_TM

CHRNA2 CHRNA5 CHRNB1 CHRNB2 CHRNB3

2.09e-07231115IPR027361
DomainNeurotransmitter_ion_chnl_CS

CHRNA2 CHRNA5 CHRNB1 CHRNB2 CHRNB3

6.85e-06451115IPR018000
DomainNeur_chan_memb

CHRNA2 CHRNA5 CHRNB1 CHRNB2 CHRNB3

7.64e-06461115PF02932
DomainNeur_chan_LBD

CHRNA2 CHRNA5 CHRNB1 CHRNB2 CHRNB3

8.51e-06471115PF02931
DomainNEUROTR_ION_CHANNEL

CHRNA2 CHRNA5 CHRNB1 CHRNB2 CHRNB3

8.51e-06471115PS00236
DomainNeurotrans-gated_channel_TM

CHRNA2 CHRNA5 CHRNB1 CHRNB2 CHRNB3

8.51e-06471115IPR006029
Domain-

CHRNA2 CHRNA5 CHRNB1 CHRNB2 CHRNB3

8.51e-064711152.70.170.10
DomainNeur_channel

CHRNA2 CHRNA5 CHRNB1 CHRNB2 CHRNB3

8.51e-06471115IPR006201
DomainNeur_chan_lig-bd

CHRNA2 CHRNA5 CHRNB1 CHRNB2 CHRNB3

8.51e-06471115IPR006202
DomainKRAB

ZNF136 ZNF177 ZNF212 ZNF699 ZNF850 ZKSCAN5 ZNF774 ZNF398 ZNF565 ZNF433

5.47e-0535811110PS50805
DomainKRAB

ZNF136 ZNF177 ZNF212 ZNF699 ZNF850 ZKSCAN5 ZNF398 ZNF565 ZNF433

2.87e-043581119PF01352
DomainKRAB

ZNF136 ZNF177 ZNF212 ZNF699 ZNF850 ZKSCAN5 ZNF398 ZNF565 ZNF433

3.58e-043691119SM00349
DomainKRAB

ZNF136 ZNF177 ZNF212 ZNF699 ZNF850 ZKSCAN5 ZNF398 ZNF565 ZNF433

3.65e-043701119IPR001909
DomainDUF3669_Znf

ZNF212 ZNF398

5.17e-0461112IPR022137
DomainDUF3669

ZNF212 ZNF398

5.17e-0461112PF12417
Domainzf-C2H2_6

ZNF136 ZNF212 ZNF699 ZNF883 ZNF850 ZKSCAN5 ZNF433 ZNF572

5.76e-043141118PF13912
DomainZnf_SWIM

ZSWIM5 ZSWIM6

1.23e-0391112IPR007527
DomainZF_SWIM

ZSWIM5 ZSWIM6

1.23e-0391112PS50966
DomainDUF4599

SPATA31D4 SPATA31D3

2.22e-03121112PF15371
DomainDUF4599

SPATA31D4 SPATA31D3

2.22e-03121112IPR027970
Domain-

F8 EFNB2

3.04e-031411122.60.40.420
DomainCADHERIN_1

PCDHB5 PCDHB4 CLSTN2 FAT1

4.63e-031131114PS00232
DomainCadherin

PCDHB5 PCDHB4 CLSTN2 FAT1

4.63e-031131114PF00028
DomainCADHERIN_2

PCDHB5 PCDHB4 CLSTN2 FAT1

4.78e-031141114PS50268
Domain-

PCDHB5 PCDHB4 CLSTN2 FAT1

4.78e-0311411142.60.40.60
DomainCA

PCDHB5 PCDHB4 CLSTN2 FAT1

4.93e-031151114SM00112
DomainCadherin-like

PCDHB5 PCDHB4 CLSTN2 FAT1

5.08e-031161114IPR015919
DomainCadherin

PCDHB5 PCDHB4 CLSTN2 FAT1

5.40e-031181114IPR002126
DomainCupredoxin

F8 EFNB2

7.48e-03221112IPR008972
DomainADAM_spacer1

ADAMTS6 ADAMTS20

8.16e-03231112IPR010294
PathwayREACTOME_HIGHLY_CALCIUM_PERMEABLE_NICOTINIC_ACETYLCHOLINE_RECEPTORS

CHRNA2 CHRNA5 CHRNB2 CHRNB3

6.89e-089704M27597
PathwayREACTOME_HIGHLY_CALCIUM_PERMEABLE_NICOTINIC_ACETYLCHOLINE_RECEPTORS

CHRNA2 CHRNA5 CHRNB2 CHRNB3

6.89e-089704MM15313
PathwayREACTOME_HIGHLY_CALCIUM_PERMEABLE_POSTSYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS

CHRNA2 CHRNA5 CHRNB2 CHRNB3

1.79e-0711704M883
PathwayREACTOME_PRESYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS

CHRNA2 CHRNA5 CHRNB2 CHRNB3

2.68e-0712704M48008
PathwayREACTOME_HIGHLY_CALCIUM_PERMEABLE_POSTSYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS

CHRNA2 CHRNA5 CHRNB2 CHRNB3

2.68e-0712704MM15312
PathwayREACTOME_ACETYLCHOLINE_BINDING_AND_DOWNSTREAM_EVENTS

CHRNA2 CHRNA5 CHRNB2 CHRNB3

5.37e-0714704M757
PathwayREACTOME_ACETYLCHOLINE_BINDING_AND_DOWNSTREAM_EVENTS

CHRNA2 CHRNA5 CHRNB2 CHRNB3

7.30e-0715704MM14704
Pubmed

Resequencing of nicotinic acetylcholine receptor genes and association of common and rare variants with the Fagerström test for nicotine dependence.

CHRNA2 CHRNA5 CHRNB1 CHRNB2 CHRNB3

8.24e-1110113520736995
Pubmed

Analysis of nicotinic acetylcholine receptor subunits in the cochlea of the mouse.

CHRNA2 CHRNA5 CHRNB1 CHRNB2 CHRNB3

9.69e-101511358838678
Pubmed

Multiple distinct risk loci for nicotine dependence identified by dense coverage of the complete family of nicotinic receptor subunit (CHRN) genes.

CHRNA2 CHRNA5 CHRNB1 CHRNB2 CHRNB3

1.41e-0916113519259974
Pubmed

Chromosomal localization of seven neuronal nicotinic acetylcholine receptor subunit genes in humans.

CHRNA2 CHRNA5 CHRNB2 CHRNB3

3.67e-09711341505988
Pubmed

No evidence for association between 19 cholinergic genes and bipolar disorder.

CHRNA2 CHRNA5 CHRNB1 CHRNB2 CHRNB3

3.71e-0919113517373692
Pubmed

Why do young women smoke? V. Role of direct and interactive effects of nicotinic cholinergic receptor gene variation on neurocognitive function.

CHRNA2 CHRNA5 CHRNB2 CHRNB3

7.32e-098113417559419
Pubmed

Comparative structure of human neuronal alpha 2-alpha 7 and beta 2-beta 4 nicotinic acetylcholine receptor subunits and functional expression of the alpha 2, alpha 3, alpha 4, alpha 7, beta 2, and beta 4 subunits.

CHRNA2 CHRNA5 CHRNB2 CHRNB3

1.31e-08911348906617
Pubmed

Rodent habenulo-interpeduncular pathway expresses a large variety of uncommon nAChR subtypes, but only the alpha3beta4* and alpha3beta3beta4* subtypes mediate acetylcholine release.

CHRNA2 CHRNA5 CHRNB2 CHRNB3

1.31e-089113419228980
Pubmed

Effect of neuronal nicotinic acetylcholine receptor genes (CHRN) on longitudinal cigarettes per day in adolescents and young adults.

CHRNA2 CHRNA5 CHRNB3

3.34e-083113323943838
Pubmed

Differential expression of nicotinic acetylcholine receptor subunits in fetal and neonatal mouse thymus.

CHRNA2 CHRNA5 CHRNB2 CHRNB3

3.43e-0811113412225896
Pubmed

Multiple cholinergic nicotinic receptor genes affect nicotine dependence risk in African and European Americans.

CHRNA2 CHRNA5 CHRNB1 CHRNB3

5.13e-0812113420584212
Pubmed

Design and expression of human alpha7 nicotinic acetylcholine receptor extracellular domain mutants with enhanced solubility and ligand-binding properties.

CHRNA2 CHRNA5 CHRNB2 CHRNB3

1.03e-0714113419059502
Pubmed

Unorthodox Acetylcholine Binding Sites Formed by α5 and β3 Accessory Subunits in α4β2* Nicotinic Acetylcholine Receptors.

CHRNA5 CHRNB2 CHRNB3

1.33e-074113327645992
Pubmed

Association of genes coding for the alpha-4, alpha-5, beta-2 and beta-3 subunits of nicotinic receptors with cigarette smoking and nicotine dependence.

CHRNA5 CHRNB2 CHRNB3

1.33e-074113319482438
Pubmed

CHRNB2 promoter region: association with subjective effects to nicotine and gene expression differences.

CHRNA5 CHRNB2 CHRNB3

1.33e-074113320854418
Pubmed

Expression of the alpha 7 subunit of the nicotinic acetylcholine receptor in normal and myasthenic human thymuses.

CHRNA2 CHRNA5 CHRNB3

3.32e-07511339193799
Pubmed

Nicotinic acetylcholine receptors: from structure to brain function.

CHRNA2 CHRNA5 CHRNB3

3.32e-075113312783266
Pubmed

The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.

BCLAF1 GOLM2 MAZ PCDHB5 ZNF362 DCLRE1B SMC5 ZNF850 PTGFRN REPIN1 JMJD1C ZNF691 PIGT UTP4 NOTCH2 RNF111 SYMPK

3.60e-0712031131729180619
Pubmed

Performance of alpha7 nicotinic receptor null mutants is impaired in appetitive learning measured in a signaled nose poke task.

CHRNA5 CHRNB2 CHRNB3

6.63e-076113315922075
Pubmed

Cloning and sequence of full-length cDNAs encoding the human neuronal nicotinic acetylcholine receptor (nAChR) subunits beta3 and beta4 and expression of seven nAChR subunits in the human neuroblastoma cell line SH-SY5Y and/or IMR-32.

CHRNA5 CHRNB2 CHRNB3

1.16e-06711339009220
Pubmed

Why do young women smoke? VI. A controlled study of nicotine effects on attention: pharmacogenetic interactions.

CHRNA2 CHRNB2 CHRNB3

1.16e-067113320231857
Pubmed

Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.

SORBS1 ZMIZ1 TAOK2 RESF1 KATNIP TANGO6

4.42e-06130113612421765
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

ZBTB20 GOLM2 ZNF362 ZSWIM6 ZMIZ1 AHDC1 JMJD1C HIVEP3 PTPRB EFNB2 CLK2 NFIC EEPD1 KATNIP NLGN2 ZNF839 NOTCH2

6.43e-0614891131728611215
Pubmed

Temporal patterning of apical progenitors and their daughter neurons in the developing neocortex.

ZBTB20 CLSTN2 EFNB2 NOTCH2 CDON

7.40e-0682113531073041
Pubmed

Gamma glutamyl transferase activity is independently associated with oxidative stress rather than SYNTAX score.

GGT2P GGT1

1.05e-052113225180444
Pubmed

Assembly of human neuronal nicotinic receptor alpha5 subunits with alpha3, beta2, and beta4 subunits.

CHRNA5 CHRNB2

1.05e-05211328663494
Pubmed

Requirement of nicotinic acetylcholine receptor subunit beta2 in the maintenance of spiral ganglion neurons during aging.

CHRNA5 CHRNB2

1.05e-052113215788760
Pubmed

Plasticity of prefrontal attention circuitry: upregulated muscarinic excitability in response to decreased nicotinic signaling following deletion of α5 or β2 subunits.

CHRNA5 CHRNB2

1.05e-052113222072695
Pubmed

Association of single nucleotide polymorphisms of nicotinic acetylcholine receptor subunits with cervical neoplasia.

CHRNA5 CHRNB1

1.05e-052113222406075
Pubmed

ZNF774 is a potent suppressor of hepatocarcinogenesis through dampening the NOTCH2 signaling.

ZNF774 NOTCH2

1.05e-052113231659254
Pubmed

Association between serum γ-glutamyltranspeptidase and atherosclerosis: a population-based cross-sectional study.

GGT2P GGT1

1.05e-052113225280803
Pubmed

Nicotinic receptors in the habenulo-interpeduncular system are necessary for nicotine withdrawal in mice.

CHRNA2 CHRNA5

1.05e-052113219279237
Pubmed

Binding to gating transduction in nicotinic receptors: Cys-loop energetically couples to pre-M1 and M2-M3 regions.

CHRNB1 CHRNB2

1.05e-052113219279256
Pubmed

Clinical application value of hepatitis B virus basal core promoter 1762/1764 and GGTII and GGT in patients with HBV-DNA-positive primary liver cancer.

GGT2P GGT1

1.05e-052113237904480
Pubmed

Human GGT2 does not autocleave into a functional enzyme: A cautionary tale for interpretation of microarray data on redox signaling.

GGT2P GGT1

1.05e-052113223682772
Pubmed

CHRNB2 is the second acetylcholine receptor subunit associated with autosomal dominant nocturnal frontal lobe epilepsy.

CHRNB1 CHRNB2

1.05e-052113211104662
Pubmed

[Mutational analysis of CHRNB2 and CHRNA2 genes in southern Chinese population with autosomal dominant nocturnal frontal lobe epilepsy].

CHRNA2 CHRNB2

1.05e-052113221287502
Pubmed

Catecholamine outflow from mouse and rat brain slice preparations evoked by nicotinic acetylcholine receptor activation and electrical field stimulation.

CHRNA5 CHRNB2

1.05e-052113217401441
Pubmed

Genome wide expression profiling of the mesodiencephalic region identifies novel factors involved in early and late dopaminergic development.

CHRNA5 CHRNB2 CHRNB3

1.18e-0514113323213462
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

SLC37A3 SZT2 RTTN REPIN1 AHDC1 TAOK2 HIVEP3 FAT1 ZNF398 ZFYVE26 NLGN2 ZNF839 NOTCH2 SYMPK

1.45e-0511051131435748872
Pubmed

Identification of candidate genes at the corticoseptal boundary during development.

ZBTB20 ACIN1 NOTCH2

1.48e-0515113316458080
Pubmed

Rapid isolation and characterization of 118 novel C2H2-type zinc finger cDNAs expressed in human brain.

ZNF212 ZBTB18

3.13e-05311327633419
Pubmed

Phosphorylation-induced conformational dynamics in an intrinsically disordered protein and potential role in phenotypic heterogeneity.

HIPK1 CLK2

3.13e-053113228289210
Pubmed

Acetylcholine-stimulated [3H]GABA release from mouse brain synaptosomes is modulated by alpha4beta2 and alpha4alpha5beta2 nicotinic receptor subtypes.

CHRNA5 CHRNB2

3.13e-053113219139153
Pubmed

A novel mutation of the nicotinic acetylcholine receptor gene CHRNA4 in sporadic nocturnal frontal lobe epilepsy.

CHRNA2 CHRNB2

3.13e-053113219058950
Pubmed

Identification of pharmacogenetic markers in smoking cessation therapy.

CHRNA2 CHRNA5

3.13e-053113218165968
Pubmed

Expression of functional human α6β2β3* acetylcholine receptors in Xenopus laevis oocytes achieved through subunit chimeras and concatamers.

CHRNB2 CHRNB3

3.13e-053113220923852
Pubmed

Identification of four classes of brain nicotinic receptors using beta2 mutant mice.

CHRNB1 CHRNB2

3.13e-05311329614223
Pubmed

Alpha4 and beta2 subunits of neuronal nicotinic acetylcholine receptor genes are not associated with methamphetamine-use disorder in the Japanese population.

CHRNA2 CHRNB2

3.13e-053113218991851
Pubmed

The role of the nAChR subunits α5, β2, and β4 on synaptic transmission in the mouse superior cervical ganglion.

CHRNA5 CHRNB2

3.13e-053113230891952
Pubmed

Acetylcholine receptor (AChR) α5 subunit variant associated with risk for nicotine dependence and lung cancer reduces (α4β2)₂α5 AChR function.

CHRNA5 CHRNB2

3.13e-053113220881005
Pubmed

Nicotine enhances excitability of medial habenular neurons via facilitation of neurokinin signaling.

CHRNA5 CHRNB2

3.13e-053113224647947
Pubmed

Efficient expression of functional (α6β2)2β3 AChRs in Xenopus oocytes from free subunits using slightly modified α6 subunits.

CHRNB2 CHRNB3

3.13e-053113225068303
Pubmed

Binding of HIV-1 gp120 to the nicotinic receptor.

CHRNB1 CHRNB2

3.13e-05311321397297
Pubmed

Hidden function of neuronal nicotinic acetylcholine receptor beta2 subunits in ganglionic transmission: comparison to alpha5 and beta4 subunits.

CHRNA5 CHRNB2

3.13e-053113215694199
Pubmed

Different gamma-glutamyl transpeptidase mRNAs are expressed in human liver and kidney.

GGT2P GGT1

3.13e-05311322573352
Pubmed

Probing the non-canonical interface for agonist interaction with an α5 containing nicotinic acetylcholine receptor.

CHRNA5 CHRNB2

3.13e-053113224144909
Pubmed

CHRNA2 mutations are rare in the NFLE population: evaluation of a large cohort of Italian patients.

CHRNA2 CHRNB2

3.13e-053113218226955
Pubmed

Characterization of the murine Ephrin-B2 promoter.

MAZ EFNB2

3.13e-053113219268698
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

TUBGCP5 PTGFRN ZKSCAN5 JMJD1C HIVEP3 EEPD1 UTP4 NLGN2 TANGO6

3.48e-05493113915368895
Pubmed

Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis.

DBH CHRNA2 CHRNA5 CHRNB2 CHRNB3

4.33e-05118113519156168
Pubmed

Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.

DBH CHRNA2 CHRNA5 CHRNB1 CHRNB2 CHRNB3 NLGN2

5.86e-05300113719086053
Pubmed

A novel role for acinus and MCM2 as host-specific signaling enhancers of DNA-damage-induced apoptosis in association with viral protein gp70.

MCM2 ACIN1

6.25e-054113219058849
Pubmed

Selectivity of ABT-089 for alpha4beta2* and alpha6beta2* nicotinic acetylcholine receptors in brain.

CHRNA5 CHRNB2

6.25e-054113219481067
Pubmed

Differential role of nicotinic acetylcholine receptor subunits in physical and affective nicotine withdrawal signs.

CHRNA5 CHRNB2

6.25e-054113218184829
Pubmed

Examination of the nicotine dependence (NICSNP) consortium findings in the Iowa adoption studies population.

CHRNA2 CHRNB1

6.25e-054113219307444
Pubmed

Reversing EphB2 depletion rescues cognitive functions in Alzheimer model.

ZBTB20 EFNB2

6.25e-054113221113149
Pubmed

Subunit composition of α5-containing nicotinic receptors in the rodent habenula.

CHRNA5 CHRNB2

6.25e-054113222380605
Pubmed

Ceramides modulate cell-surface acetylcholine receptor levels.

CHRNA2 CHRNB1

6.25e-054113218023270
Pubmed

Striatal α5 nicotinic receptor subunit regulates dopamine transmission in dorsal striatum.

CHRNA5 CHRNB3

6.25e-054113222396410
Pubmed

Peer smoking and the nicotinic receptor genes: an examination of genetic and environmental risks for nicotine dependence.

CHRNA5 CHRNB3

6.25e-054113220840187
Pubmed

Cholinergic nicotinic receptor genes implicated in a nicotine dependence association study targeting 348 candidate genes with 3713 SNPs.

CHRNA5 CHRNB3

6.25e-054113217135278
Pubmed

Why do young women smoke? I. Direct and interactive effects of environment, psychological characteristics and nicotinic cholinergic receptor genes.

CHRNB2 CHRNB3

6.25e-054113216314871
Pubmed

Transcription factor GATA-3 regulates the transcriptional activity of dopamine beta-hydroxylase by interacting with Sp1 and AP4.

DBH REPIN1

6.25e-054113218338249
Pubmed

Lung lining fluid glutathione attenuates IL-13-induced asthma.

GGT2P GGT1

1.04e-045113218063838
Pubmed

Gamma-glutamyltranspeptidase knockout mice as a model for understanding the consequences of diminished glutathione on T cell-dependent immune responses.

GGT2P GGT1

1.04e-045113210940879
Pubmed

Cataract development in gamma-glutamyl transpeptidase-deficient mice.

GGT2P GGT1

1.04e-045113211095909
Pubmed

Expression of gamma-glutamyl transpeptidase in midgestation mouse yolk sac and mouse visceral yolk sac carcinoma cells.

GGT2P GGT1

1.04e-04511327641802
Pubmed

Phenotypic characterization of Ggt1(dwg/dwg) mice,a mouse model for hereditary γ-glutamyltransferase deficiency.

GGT2P GGT1

1.04e-045113223615310
Pubmed

Biochemical and functional properties of distinct nicotinic acetylcholine receptors in the superior cervical ganglion of mice with targeted deletions of nAChR subunit genes.

CHRNA5 CHRNB2

1.04e-045113220377613
Pubmed

The mouse skin carcinogenesis model.

GGT2P GGT1

1.04e-04511329627710
Pubmed

Gamma-glutamyl transpeptidase and its role in melanogenesis: redox reactions and regulation of tyrosinase.

GGT2P GGT1

1.04e-045113212453183
Pubmed

gamma-glutamyltranspeptidase-deficient knockout mice as a model to study the relationship between glutathione status, mitochondrial function, and cellular function.

GGT2P GGT1

1.04e-045113211003618
Pubmed

Gamma-glutamyl transpeptidase gene organization and expression: a comparative analysis in rat, mouse, pig and human species.

GGT2P GGT1

1.04e-045113210392451
Pubmed

Immunocytochemical localization of gamma-glutamyltranspeptidase during fetal development of mouse kidney.

GGT2P GGT1

1.04e-04511322891746
Pubmed

Hyperoxia-induced lung injury in gamma-glutamyl transferase deficiency is associated with alterations in nitrosative and nitrative stress.

GGT2P GGT1

1.04e-045113219850887
Pubmed

Differential expression and function of nicotinic acetylcholine receptors in subdivisions of medial habenula.

CHRNB2 CHRNB3

1.04e-045113225031416
Pubmed

Reversible skeletal abnormalities in gamma-glutamyl transpeptidase-deficient mice.

GGT2P GGT1

1.04e-045113212810527
Pubmed

Growth retardation and cysteine deficiency in gamma-glutamyl transpeptidase-deficient mice.

GGT2P GGT1

1.04e-04511328755578
Pubmed

Reproductive defects in gamma-glutamyl transpeptidase-deficient mice.

GGT2P GGT1

1.04e-045113211089562
Pubmed

Liver-Specific Overexpression of Gamma-Glutamyltransferase Ameliorates Insulin Sensitivity of Male C57BL/6 Mice.

GGT2P GGT1

1.04e-045113228660214
Pubmed

Bleomycin-induced pulmonary fibrosis is attenuated in gamma-glutamyl transpeptidase-deficient mice.

GGT2P GGT1

1.04e-045113212468440
Pubmed

N-acetyl-cysteine prevents age-related hearing loss and the progressive loss of inner hair cells in γ-glutamyl transferase 1 deficient mice.

GGT2P GGT1

1.04e-045113226977590
Pubmed

Low ethanol concentration alters CHRNA5 RNA levels during early human development.

CHRNA5 CHRNB2

1.04e-045113220438829
Pubmed

Gamma-glutamyl transferase deficiency results in lung oxidant stress in normoxia.

GGT2P GGT1

1.04e-045113212225953
Pubmed

Identification of a sixth promoter that directs the transcription of gamma-glutamyl transpeptidase type III RNA in mouse.

GGT2P GGT1

1.04e-04511327775425
Pubmed

Cloning of cDNA and genomic structure of the mouse gamma-glutamyl transpeptidase-encoding gene.

GGT2P GGT1

1.04e-04511328566783
Pubmed

Therapeutic Effect of GGsTop, Selective Gamma-glutamyl Transpeptidase Inhibitor, on a Mouse Model of 5-Fluorouracil-induced Oral Mucositis.

GGT2P GGT1

1.04e-045113230591459
Pubmed

Mice with genetic gamma-glutamyl transpeptidase deficiency exhibit glutathionuria, severe growth failure, reduced life spans, and infertility.

GGT2P GGT1

1.04e-04511329139708
Pubmed

Analysis of site-specific glycosylation of renal and hepatic γ-glutamyl transpeptidase from normal human tissue.

GGT2P GGT1

1.04e-045113220622017
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ZNF136 ZBTB20 ZNF177 ZNF212 MAZ ZNF362 ZNF699 ZNF883 ZNF850 REPIN1 ZKSCAN5 ZNF774 ZNF691 HIVEP3 ZNF594 ZNF398 ZNF565 ZBTB18 ZNF433 ZNF572

9.85e-12718762028
GeneFamilyCholinergic receptors nicotinic subunits

CHRNA2 CHRNA5 CHRNB1 CHRNB2 CHRNB3

4.84e-0916765173
GeneFamilyZinc fingers SWIM-type|Mitogen-activated protein kinase kinase kinases

ZSWIM5 ZSWIM6

6.16e-04976290
GeneFamilyCD molecules|Gamma-glutamyltransferases

GGT2P GGT1

1.32e-0313762564
GeneFamilyCadherin related

CLSTN2 FAT1

2.28e-031776224
GeneFamilyADAM metallopeptidases with thrombospondin type 1 motif

ADAMTS6 ADAMTS20

2.85e-031976250
ToppCellCOVID-19-Endothelial_cells-Endothelial_cells_(other)|COVID-19 / group, cell type (main and fine annotations)

SORBS1 F8 PTPRB EFNB2 ADAMTS6 HYAL2

6.90e-06181113626eb4ee57a70dbf54e096b73129fda9dfda1f6ec
ToppCellPND07-28-samps-Endothelial-Postnatal_endothelial-capillary_endothelial_Hpgd-CA4_high|PND07-28-samps / Age Group, Lineage, Cell class and subclass

SORBS1 PTPRB EFNB2 ZBTB18 HYAL2 TANGO6

6.90e-0618111369cd5e5c285c2b628db9d59709af053defd7c0aff
ToppCell10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8|GI_small-bowel / Manually curated celltypes from each tissue

ZBTB20 BCLAF1 HIPK1 ARFGEF1 JMJD1C DDHD1

8.57e-061881136ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCellCOVID-19-Endothelial_cells|COVID-19 / group, cell type (main and fine annotations)

SORBS1 F8 PTPRB EFNB2 ADAMTS6 HYAL2

9.10e-0619011369fbd92cd6d4683b2490504d29c43cf42020433d4
ToppCellChildren_(3_yrs)-Endothelial-capillary_endothelial_cell_(Cap1)|Children_(3_yrs) / Lineage, Cell type, age group and donor

SORBS1 F8 PTPRB EFNB2 ADAMTS6 HYAL2

1.02e-05194113671ac69cdf7a08ca3ddfb5b492b14ac56b6cd5e5d
ToppCellfacs-Heart-RA-18m-Endothelial|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SORBS1 TAOK2 PTPRB EFNB2 EEPD1 HYAL2

1.06e-05195113630c75761079fa1e1a3b84d23c88a222f459d5ce5
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

SORBS1 F8 PTPRB EFNB2 ADAMTS6 HYAL2

1.09e-051961136d37f714d4fb57e958f3738fdda085560813e5bb5
ToppCellBronchial-NucSeq-Endothelial-Endothelia_vascular-VE_capillary|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

SORBS1 F8 PTPRB EFNB2 ADAMTS6 HYAL2

1.12e-05197113681718164c9802ee20c860ffbda7e62d5e9a76f16
ToppCellBronchial-NucSeq-Endothelial-Endothelia_vascular|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

SORBS1 PTPRB EFNB2 ADAMTS6 EEPD1 HYAL2

1.15e-051981136a1ccbf0e653b2dd665c2254920eb9b37243cc0bd
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Endothelial|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

F8 HIVEP3 PTPRB EFNB2 ADAMTS6 HYAL2

1.15e-051981136440af8f90c7afa1c07000806bcf9110b70f489fb
ToppCellCOVID-19-lung-Capillary_2|lung / Disease (COVID-19 only), tissue and cell type

SORBS1 F8 PTPRB EFNB2 ADAMTS6 HYAL2

1.18e-051991136793ce71b78a68033ef4419ed571e1dd86b40124f
ToppCellBrain_organoid-organoid_Paulsen_bioRxiv-1_mon-Proliferating-Cycling_Progenitors|1_mon / Sample Type, Dataset, Time_group, and Cell type.

GOLM2 DHX33 GLCCI1 FAT1 NOTCH2 CDON

1.18e-051991136358c4b3037f59378db8916a2fbe9ed4830cf1449
ToppCellSigmoid-T_cell-cycling_gd_T|T_cell / Region, Cell class and subclass

DCLRE1B ZMIZ1 ZNF594 JRK ZFYVE26 PARPBP

1.22e-0520011364e489ecf472857357d45e9f6c7a812aa48b72ebf
ToppCell390C-Myeloid-Macrophage-SPP1+_Macrophage_2|Macrophage / Donor, Lineage, Cell class and subclass (all cells)

TRIM39 ZSWIM6 EFNB2 ZNF839 FCMR

5.50e-0516011358aaf6ac4f33ea291387fdbf9ff1a91d559391774
ToppCellTCGA-Brain-Primary_Tumor-Low_Grade_Glioma-Astrocytoma|TCGA-Brain / Sample_Type by Project: Shred V9

SZT2 HIPK1 SORBS1 ZNF362 NOTCH2

5.84e-051621135810881210e015c788814e4fe8d7a24c929cf2621
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW09-Macroglial|GW09 / Sample Type, Dataset, Time_group, and Cell type.

ADAMTS6 BEND7 NOTCH2 CDON

5.95e-058311347893ce9fbf34c6250dca9c265fe9b2d4cb889ade
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell_prolif|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

DCLRE1B F8 TAOK2 PTPRB HYAL2

6.55e-0516611359d4b44eb56ad38c26aed73444edf389abca6bdf6
ToppCellAdult-Endothelial-endothelial_cell_of_artery-D231|Adult / Lineage, Cell type, age group and donor

F8 PTPRB EFNB2 ADAMTS6 C13orf42

6.93e-051681135aca34c51758c65925ad24110294a72b2dea6db72
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

PTPRB EFNB2 HMCN2 ADAMTS6 HYAL2

7.13e-051691135c7fc3a8c44f07c557b60d469717b66e2f5863d38
ToppCell367C-Epithelial_cells-Epithelial-J_(AT1-AT2_progenitors)-|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

ZNF850 PTPRB ADAMTS6 ZNF565 PARPBP

7.54e-051711135e3cab55f39879e2bd3e8bda91802181075839bc4
ToppCell367C-Epithelial_cells-Epithelial-J_(AT1-AT2_progenitors)|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

ZNF850 PTPRB ADAMTS6 ZNF565 PARPBP

7.54e-05171113552fdc2a4ec36fb91583b1215362548ceb6740ae1
ToppCell3'-Broncho-tracheal-Endothelial-Blood_vessel_EC-pulmonary_artery_endothelial_cell-EC_arterial-EC_arterial_L.2.4.0.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

F8 PTPRB EFNB2 ADAMTS6 HYAL2

8.18e-05174113518ab52d8bbca0507fee220e0c4fc765fc47dda34
ToppCellPND07-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC-VEC_G2M|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PTPRB PARPBP HYAL2 TANGO6 SYMPK

8.18e-0517411356c36d607c48267a75ab4da6fb2fe3f931d1b3b52
ToppCell10x_3'_v2v3-Neoplastic-Differentiated-like-MES-like-MES-like_hypoxia/MHC-B|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

SCFD2 PCDHB4 SORBS1 SMC5 ZNF594

8.40e-051751135e99e145a152f534b75267ec492a252a0b814b4f8
ToppCell3'-Adult-LargeIntestine-Endothelial-lymphatic_endothelial-LEC3_(ADGRG3+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ABCA3 PCDHB4 F8 NRK HYAL2

8.63e-0517611355d3b2395bb842eea39175f5af6a4c76527e2fc31
ToppCell3'-Parenchyma_lung-Endothelial-Blood_vessel_EC-pulmonary_artery_endothelial_cell-EC_arterial-EC_arterial_L.2.4.1.3|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TUBGCP5 F8 PTPRB EFNB2 TNR

8.87e-05177113516197068260fc062bf8b730a51a199887ea580b9
ToppCelltumor_Lung-Endothelial_cells-EPCs|tumor_Lung / Location, Cell class and cell subclass

ZSWIM5 F8 PTPRB EFNB2 HYAL2

8.87e-051771135f8b152c09d56a97e8c0482fb1a3964c05f9dc8c5
ToppCellCOVID-19-kidney-Stressed_EC|COVID-19 / Disease (COVID-19 only), tissue and cell type

SORBS1 JMJD1C CHRNA5 PTPRB EFNB2

9.35e-051791135754f69bac7a1d5137f5141f6193285ccbfe361cb
ToppCellCOVID-19-kidney-PLVAP+EC|COVID-19 / Disease (COVID-19 only), tissue and cell type

SORBS1 F8 JMJD1C PTPRB EFNB2

9.60e-051801135493cf8d1a8f2a1ed2672f394a0338b110fd81d88
ToppCell10x3'2.3-week_12-13-Lymphocytic_B-B_lineage-immature_B_cell|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

ZNF699 ADAMTS6 ZBTB18 ZNF433 FCMR

1.01e-041821135ab78df9de3878a6d67106a40094c893601de8076
ToppCell5'-Parenchyma_lung-Endothelial-Blood_vessel_EC-pulmonary_artery_endothelial_cell-EC_arterial-EC_arterial_L.2.4.1.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

F8 PTPRB EFNB2 ADAMTS6 HYAL2

1.04e-041831135ce8be9418b473ea94ec806edc7a2078cc30c1703
ToppCellCOVID-19-Endothelial_cells-Pulmonary_venous_endothelial_cells|COVID-19 / group, cell type (main and fine annotations)

SORBS1 F8 PTPRB ADAMTS6 HYAL2

1.15e-0418711352d20193a6cacdfa4877457c97b0077408942186c
ToppCellE18.5-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SZT2 CCNJ GLCCI1 PTPRB EFNB2

1.15e-0418711353699d5e71d779da922920aa3160895db187bf81b
ToppCellhuman_hepatoblastoma-Tumor_cells-T2|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)

SCFD2 ZBTB20 ZSWIM5 ELP1 ADAMTS6

1.15e-041871135f3e37c18ac6471c7992609bbddfa4975571c815c
ToppCellControl-Endothelial_cells-Endothelial_cells_(general)|Control / group, cell type (main and fine annotations)

SORBS1 PTPRB EFNB2 TNR HYAL2

1.15e-041871135fb5bcbc8effdbf0e57fcb71aca990a4aa0d65ce8
ToppCellE18.5-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1-CAP1_mature|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SZT2 CCNJ GLCCI1 PTPRB EFNB2

1.15e-041871135033ba52c0c2f9978784947098fa697368ae44834
ToppCellAdult-Endothelial-capillary_endothelial_cell_(Cap1)-D122|Adult / Lineage, Cell type, age group and donor

SORBS1 PTPRB EFNB2 ADAMTS6 HYAL2

1.18e-04188113502a62888e9db29d20133eeca1686d302545a39c9
ToppCell10x3'2.3-week_14-16-Mesenchymal_myocytic-stroma-muscle_stem_cell|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

PCDHB5 PTGFRN FRMD1 FAT1 NRK

1.18e-041881135de6f4889e0c5f39fbbaefd85526f645c6afa09d5
ToppCellControl-Endothelial_cells|Control / group, cell type (main and fine annotations)

SORBS1 PTPRB EFNB2 TNR HYAL2

1.18e-0418811353953b08abfea93468fc8d177bdb16ca7c6ffa1ab
ToppCellEndothelial-endothelial_cell_of_artery|World / Lineage, Cell type, age group and donor

F8 PTPRB EFNB2 ADAMTS6 HYAL2

1.21e-041891135fdd89c71113ac99b7c800c6def8888e512ff1128
ToppCell5'-GW_trimst-2-LargeIntestine-Endothelial-lymphatic_endothelial-LEC1_(ACKR4+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

DHX33 CCNJ CHRNA5 ZNF691 HYAL2

1.21e-0418911350739baad9a7da511dd3d7249f84299aee88370a1
ToppCellfacs-Lung-3m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_endothelial_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

GOLM2 SORBS1 PTPRB EFNB2 HYAL2

1.21e-04189113516e019fd6e2376110b767739754389891f391669
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

F8 PTPRB EFNB2 ADAMTS6 HYAL2

1.24e-041901135bf9bc57a605c7e3979bc4f7260e6fb92c3eb8690
ToppCellCOVID-19-Endothelial_cells-Endothelial_cells_(general)|COVID-19 / group, cell type (main and fine annotations)

SORBS1 F8 PTPRB EFNB2 ADAMTS6

1.24e-041901135812e11314c76c0179fbe5a9bea29b41ce5cbc93d
ToppCellControl-Endothelial-VE_Capillary_B|Endothelial / Disease state, Lineage and Cell class

SORBS1 FAT1 PTPRB ADAMTS6 EEPD1

1.24e-0419011357f3f419fffe02934b6f27b697f7a6401072491ed
ToppCellLPS-IL1RA-Endothelial-Endothelial-Alv_Gen_Intermediate|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SORBS1 PTPRB EFNB2 ADAMTS6 EEPD1

1.24e-041901135106ea0bb7b99c697ffc5443d72343df2484250c7
ToppCellEndothelial-A-Myositis-ILD_01|World / lung cells shred on cell class, cell subclass, sample id

F8 PTPRB EFNB2 ADAMTS6 HYAL2

1.27e-041911135f702dfe88a9b04091dae87df61b2b4f43525f86a
ToppCellfacs-Marrow-T-cells-3m-Lymphocytic-immature_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GLCCI1 DMXL1 HIVEP3 ZBTB18 FCMR

1.30e-0419211352de242d81dc085ae734eb7d1f091af9a542e0866
ToppCellCOVID-19-kidney-AQP1+PLVAP+EC|COVID-19 / Disease (COVID-19 only), tissue and cell type

F8 PTPRB EFNB2 ADAMTS6 HYAL2

1.30e-04192113527ff3621e177e7932dd44dd6baa81551ea75a874
ToppCellfacs-Lung-18m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_endothelial_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

GOLM2 SORBS1 PTPRB EFNB2 HYAL2

1.30e-041921135dfa6adc776621f4b51d731b796c0421855b2297c
ToppCellfacs-Marrow-T-cells-3m-Lymphocytic-immature_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GLCCI1 DMXL1 HIVEP3 ZBTB18 FCMR

1.30e-041921135ba2a683472a8b785dbf666dc6e94356d879486c3
ToppCellfacs-Lung-24m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_endothelial_cell|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

GOLM2 SORBS1 PTPRB EFNB2 HYAL2

1.30e-041921135517bc24b9ad5e2b5a3609ca55d7327c4700db9db
ToppCellAdult-Endothelial-capillary_endothelial_cell_(Cap1)|Adult / Lineage, Cell type, age group and donor

SORBS1 PTPRB EFNB2 ADAMTS6 HYAL2

1.33e-04193113539c6c96a2a100b1b290a779d36cc6bc17245720b
ToppCellIPF-Endothelial-VE_Capillary_B|World / Disease state, Lineage and Cell class

SORBS1 PTPRB EFNB2 ADAMTS6 HYAL2

1.33e-041931135d7750a7575ef257963b7f1c64fa67c52dbff797b
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

PTPRB EFNB2 HMCN2 ADAMTS6 HYAL2

1.33e-041931135cc355b2ed6510619cad969ae074126d7c8db784d
ToppCellfacs-Lung-18m-Endothelial-capillary_endothelial|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

GOLM2 SORBS1 PTPRB EFNB2 HYAL2

1.33e-041931135ee4b31d9c92f8fd0d3ddb5e723b82300fcb459d1
ToppCellnucseq-Endothelial-Endothelial_Vascular-Endothelial_capillary-CAP1|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

SORBS1 PTPRB EFNB2 ADAMTS6 HYAL2

1.33e-041931135ad3f4fcc8e2816d696cbcde744dc16500e51ccac
ToppCellfacs-Lung-18m-Endothelial-capillary_endothelial-capillary_endothelial_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

GOLM2 SORBS1 PTPRB EFNB2 HYAL2

1.33e-0419311357401e276b644b254c692160d0e7417ec28d50aa4
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PTPRB EFNB2 ADAMTS6 EEPD1 HYAL2

1.36e-041941135a429d22c8c9d0fd3bfa9f877a6364cecad68db30
ToppCelldroplet-Lung-1m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_endothelial_cell|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

GOLM2 SORBS1 PTPRB EFNB2 HYAL2

1.36e-0419411351ac52b00ea0b0ddbd04f5d85fa8c086980a78926
ToppCellIPF-Endothelial-VE_Capillary_B|IPF / Disease state, Lineage and Cell class

SORBS1 PTPRB EFNB2 ADAMTS6 HYAL2

1.36e-041941135169a304d5c13f08c39fad4116f093bc4a0765e9d
ToppCelldroplet-Lung-LUNG-1m-Endothelial-Capillary_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GOLM2 SORBS1 PTPRB EFNB2 HYAL2

1.36e-041941135f6c9cc362ccdbc7e790f7c8d1c56cab3557c5306
ToppCellChildren_(3_yrs)-Endothelial-capillary_endothelial_cell_(Cap1)-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

SORBS1 PTPRB ADAMTS6 EEPD1 HYAL2

1.36e-04194113540842a7160f337bfc191ee15fbda3e3d38a04c57
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PTPRB EFNB2 HMCN2 ADAMTS6 HYAL2

1.40e-0419511356bdef651cf73d7381e5012d0eb3c809138fb6b92
ToppCellfacs-Marrow-B-cells-3m-Lymphocytic-immature_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GLCCI1 DMXL1 HIVEP3 ZBTB18 FCMR

1.40e-041951135d77423d0ec64b397c6d1eec181c5fc0acaa92d63
ToppCellfacs-Lung-ENDOMUCIN-18m-Endothelial-Capillary_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GOLM2 SORBS1 PTPRB EFNB2 HYAL2

1.40e-04195113552b2bbf12e5f86c493f6634697aeb23a68cc916d
ToppCellfacs-Lung-ENDOMUCIN-18m-Endothelial-endothelial_cell_of_lung|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GOLM2 SORBS1 PTPRB EFNB2 HYAL2

1.40e-041951135e5f14f6015ea5e6fa065f906ad22157e3de15c68
ToppCellfacs-Lung-ENDOMUCIN-18m-Endothelial|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GOLM2 SORBS1 PTPRB EFNB2 HYAL2

1.40e-0419511355b84fd5be31386eb1d6048bbf28626032361842e
ToppCellfacs-Marrow-B-cells-3m-Lymphocytic-immature_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GLCCI1 DMXL1 HIVEP3 ZBTB18 FCMR

1.40e-041951135f5bf4797972185afa76638293166abd536e5472f
ToppCellChildren_(3_yrs)-Endothelial|Children_(3_yrs) / Lineage, Cell type, age group and donor

SORBS1 F8 PTPRB EFNB2 HYAL2

1.40e-041951135094cf6591daa5ffad36e44122b6f524a3a34c2fd
ToppCellfacs-Lung-ENDOMUCIN-18m|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GOLM2 SORBS1 PTPRB EFNB2 HYAL2

1.43e-041961135f6df26ab9eebae893768a4f70a064ce9f60da93c
ToppCellkidney_cells-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PTPRB EFNB2 HMCN2 ADAMTS6 HYAL2

1.43e-041961135a20a56d8997d6db2a10046c8801c619a379de83c
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Endothelial|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

F8 PTPRB EFNB2 ADAMTS6 HYAL2

1.43e-0419611354cd1e6b7a791e11a40b19f971b7011bd11fe6273
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

F8 PTPRB EFNB2 ADAMTS6 HYAL2

1.43e-04196113522767bcf0095d9eb0cbed7cdc74e4d32d9357e1b
ToppCellSmart-start-Cell-Wel_seq-Neoplastic-Stem-like-OPC-like-OPC-like-G|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

ZBTB20 MCM2 GLCCI1 NLGN2 TNR

1.43e-0419611358faac7fbdee3a9297023c3151ef1751605413e44
ToppCellBronchial-NucSeq-Endothelial-Endothelia_vascular-VE_pulmonary_arterial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

F8 PTPRB EFNB2 EEPD1 HYAL2

1.43e-041961135915e4a7422058be246b54760df31e8a607310625
ToppCellfacs-Lung-ENDOMUCIN|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GOLM2 SORBS1 PTPRB EFNB2 HYAL2

1.43e-04196113569f03546c42c942ab8ac8746167c8d44d574b4c6
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Endothelial|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

F8 HIVEP3 PTPRB EFNB2 ADAMTS6

1.43e-041961135adee900dcd16dbaba15c58bdcace09ba20214950
ToppCellCOVID-19-lung-Capillary_1|COVID-19 / Disease (COVID-19 only), tissue and cell type

SORBS1 F8 PTPRB EFNB2 ADAMTS6

1.43e-041961135ac28e9be288af6f00a841aea4ce4b99aed6b4505
ToppCellCOVID-19-lung-Capillary_1|lung / Disease (COVID-19 only), tissue and cell type

SORBS1 F8 PTPRB EFNB2 ADAMTS6

1.46e-0419711357e86ff9dafcbaaa7464d61484dd48bfeb7eae6e4
ToppCellnucseq-Endothelial|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

SORBS1 F8 PTPRB EFNB2 HYAL2

1.46e-041971135ebf9be068eaa658493fa7884fd19f34642922acb
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

HIVEP3 PTPRB EFNB2 ADAMTS6 HYAL2

1.50e-04198113507701c73137947ed4a27e225975329235bbb8734
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

F8 HIVEP3 PTPRB EFNB2 HYAL2

1.50e-0419811351378c6d4ceb84b42fdd6556be3296df7a8059e6e
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

F8 PTPRB EFNB2 ADAMTS6 HYAL2

1.50e-041981135451003a21162eeae90739fdb502bb50b362d80c8
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Glomerular_Capillary_Endothelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

F8 HIVEP3 PTPRB EFNB2 HYAL2

1.50e-04198113592416e65a0dc1a4bf931833407620ea05d362f56
ToppCellTracheal-NucSeq-Endothelial-Endothelia_vascular|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

PTPRB EFNB2 ADAMTS6 EEPD1 HYAL2

1.50e-041981135f7aa809040fa9f5782b92eec1f289d690eb5c7bd
ToppCellParenchymal-NucSeq-Endothelial-Endothelia_vascular-VE_capillary|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

SORBS1 F8 PTPRB EFNB2 EEPD1

1.50e-0419811351d30a1f73b6d6d838f49751402a29c5ef54aa81f
ToppCellCOVID-19-kidney-AQP1+PLVAP+EC|kidney / Disease (COVID-19 only), tissue and cell type

F8 PTPRB EFNB2 ADAMTS6 HYAL2

1.50e-0419811358689090bce9ab6e8f122426a404037e572c6713b
ToppCellNeuron-Postmitotic-Excitatory_Neuron_-Newborn-35|World / Primary Cells by Cluster

ZBTB20 BCLAF1 ZSWIM6 SLAIN1 ZBTB18

1.50e-041981135de5214a85fe017eb23d4aa8af624464f062ec57e
ToppCell(6)_Endothelial-E|World / Lung cell shreds - cell class (v4) and cell subclass (v4)

F8 PTPRB EFNB2 ADAMTS6 HYAL2

1.50e-041981135a5e1b321376caf262ea48904d31afd1b8e9d3be2
ToppCellBronchial-NucSeq-Endothelial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

F8 PTPRB EFNB2 ADAMTS6 HYAL2

1.53e-04199113536a230b80096455df26c2e2c8c05fd6b231508c5
ToppCellParenchymal-NucSeq-Endothelial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

F8 PTPRB EFNB2 EEPD1 HYAL2

1.53e-041991135a4a9a1c2a34b5a8318a55d1211d6c8661ca9793e
ToppCellTracheal-10x5prime-Endothelial-Endothelia_vascular-VE_pulmonary_arterial|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

F8 PTPRB EFNB2 ADAMTS6 HYAL2

1.53e-0419911359735a1dc10910f02f1106b20ae5ab4c09c21305e
ToppCellkidney_cells-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

F8 PTPRB EFNB2 ADAMTS6 HYAL2

1.53e-04199113533f1669eeb701986b4dec409efdb6c06c3c41c2b
ToppCellParenchyma_COVID-19-Endothelial-TX-Artery|Parenchyma_COVID-19 / Sample group, Lineage and Cell type

F8 PTPRB EFNB2 ADAMTS6 HYAL2

1.57e-04200113534b279804475ea58fbb052b96f44128c082627a9
ToppCellLung_Parenchyma-Severe-Endothelial-Endothelial-Artery|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

F8 PTPRB EFNB2 ADAMTS6 HYAL2

1.57e-0420011358552cc7a439449b30b59760c3e8667217b9852b5
ToppCellTracheal-10x5prime-Endothelial-Endothelia_vascular-VE_systemic_arterial|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

F8 PTPRB EFNB2 ADAMTS6 HYAL2

1.57e-0420011355ec31c1be6bcc4124e1489d136570f3de33cc2e9
ToppCellParenchyma_COVID-19-Endothelial-TX|Parenchyma_COVID-19 / Sample group, Lineage and Cell type

F8 PTPRB EFNB2 ADAMTS6 HYAL2

1.57e-042001135abcbd5a156aa4fd51d284441388975c81c0b88ae
ToppCellkidney_cells-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PTPRB EFNB2 HMCN2 ADAMTS6 HYAL2

1.57e-04200113593e13937ec74418a697c37d56f57509fb2154780
ToppCellLung_Parenchyma-Severe-Endothelial|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

F8 PTPRB EFNB2 ADAMTS6 HYAL2

1.57e-042001135d9d0ffa18e5b4647966e19ad9830cbba6120677e
ComputationalGenes in the cancer module 267.

CHRNA2 CHRNB1 CHRNB2 CHRNB3

1.58e-0615654MODULE_267
ComputationalIon channels.

CHRNA2 CHRNB1 CHRNB2 CHRNB3

1.93e-0527654MODULE_214
ComputationalAcetylCholine receptors.

CHRNA2 CHRNB1 CHRNB3

7.33e-0514653MODULE_328
Drugperhydrohistrionicotoxin

CHRNA2 CHRNB1 CHRNB2 CHRNB3 SYMPK

2.77e-08191115CID000107881
Drugbeta-erythroidine

CHRNA2 CHRNA5 CHRNB2

4.50e-0741113ctd:C004873
Drug(-)-pictamine

CHRNA2 CHRNB1 CHRNB2 CHRNB3

7.01e-07151114CID006918623
Drug(-)-lepadin B

CHRNA2 CHRNB1 CHRNB2 CHRNB3

7.01e-07151114CID006918624
DrugUB-165

CHRNA2 CHRNB1 CHRNB2 CHRNB3

7.01e-07151114CID004694339
DrugAC1L2SVN

CHRNA2 CHRNB1 CHRNB2 CHRNB3

9.31e-07161114CID000127922
DrugABT-594

CHRNA2 CHRNB1 CHRNB2 CHRNB3

1.55e-06181114CID003075702
DrugAC1LCVGE

CHRNA2 CHRNB1 CHRNB2 CHRNB3

1.55e-06181114CID000656712
DrugAC1L9P88

CHRNA2 CHRNB1 CHRNB2 CHRNB3

1.96e-06191114CID000450860
Drug4-(N-maleimido)benzyltrimethylammonium

CHRNA2 CHRNB1 CHRNB2 CHRNB3

1.96e-06191114CID000162425
Drugisoarecolone

CHRNA2 CHRNB1 CHRNB2 CHRNB3

1.96e-06191114CID000146970
Drugbeta-erythroidine

CHRNA2 CHRNB1 CHRNB2 CHRNB3

1.96e-06191114CID000010074
Drugdecamethonium

CHRNA2 CHRNA5 CHRNB2

2.23e-0661113ctd:C033019
Drug3-(2-azetidinylmethoxy)pyridine

CHRNA2 CHRNB1 CHRNB2 CHRNB3

2.44e-06201114CID000001962
Drug3H-diazirine

CHRNA2 CHRNB1 CHRNB2 CHRNB3 PARPBP

2.63e-06451115CID000078958
Drugphilanthotoxin

CHRNA2 CHRNB1 CHRNB2 CHRNB3 SYMPK

2.63e-06451115CID000115201
Drugdinotefuran

CHRNA2 CHRNB1 CHRNB2 CHRNB3

3.00e-06211114CID000197701
Drugmeproadifen

CHRNA2 CHRNB1 CHRNB2 CHRNB3

3.00e-06211114CID000189752
DrugAR-R17779

CHRNA2 CHRNB1 CHRNB2 CHRNB3

3.66e-06221114CID005310971
Drughistrionicotoxin

CHRNA2 CHRNB1 CHRNB2 CHRNB3

3.66e-06221114CID005282247
Drugclothianidin

CHRNA2 CHRNB1 CHRNB2 CHRNB3

3.66e-06221114CID000213027
Drugethidium bromide

DBH AHDC1 CHRNA2 CHRNB1 CHRNB2 CHRNB3

3.75e-06851116CID000003624
DrugneuroNal

CHRNA2 CHRNA5 CHRNB1 CHRNB2 CHRNB3

4.04e-06491115CID000010535
DrugAC1L3BL8

CHRNA2 CHRNB1 CHRNB2 CHRNB3

4.41e-06231114CID000086457
Drugalpha-conotoxin ImI

CHRNA2 CHRNB1 CHRNB2 CHRNB3

4.41e-06231114CID000133011
Drugalpha-conotoxin SI

CHRNA2 CHRNB1 CHRNB2 CHRNB3

4.41e-06231114CID000163979
DrugCID6325740

CHRNA2 CHRNB1 CHRNB2 CHRNB3

4.41e-06231114CID006325740
DrugABT-418

CHRNA2 CHRNB1 CHRNB2 CHRNB3

4.41e-06231114CID000119380
DrugSkpymrfamide

CHRNA2 CHRNB1 CHRNB2 CHRNB3

4.41e-06231114CID000132661
DrugMcN-A-343

CHRNA2 CHRNB1 CHRNB2 CHRNB3 BRI3

4.47e-06501115CID000004022
Drugprocyclidine

CHRNA2 CHRNB1 CHRNB2 CHRNB3

5.27e-06241114CID000004919
Druganabaseine

CHRNA2 CHRNB1 CHRNB2 CHRNB3

5.27e-06241114CID000018985
Drugintruder

CHRNA2 CHRNB1 CHRNB2 CHRNB3

5.27e-06241114CID000213021
Drugtetramethylammonium

CHRNA2 CHRNB1 CHRNB2 CHRNB3 TNR

5.99e-06531115CID000006380
DrugDimethylphenylpiperazinium Iodide

CHRNA2 CHRNA5 CHRNB2

6.20e-0681113ctd:D004246
Drugepibatidine

CHRNA2 CHRNA5 CHRNB2

6.20e-0681113ctd:C082748
Druganabasine

CHRNA2 CHRNB1 CHRNB2 CHRNB3

6.25e-06251114CID000002181
Drugvarenicline

CHRNA2 CHRNB1 CHRNB2 CHRNB3

6.25e-06251114CID000170361
Drugpempidine

CHRNA2 CHRNB1 CHRNB2 CHRNB3

6.25e-06251114CID000006603
Drugbenzquinamide

CHRNA2 CHRNB1 CHRNB2 CHRNB3

7.36e-06261114CID000002342
Drugbeta-eudesmol

CHRNA2 CHRNB1 CHRNB2 CHRNB3

7.36e-06261114CID000091457
Drugcurarine

CHRNA2 CHRNB1 CHRNB2 CHRNB3

7.36e-06261114CID000198004
Drugmethylcarbamylcholine

CHRNA2 CHRNB1 CHRNB2 CHRNB3

8.61e-06271114CID000004136
Drugnornicotine

CHRNA2 CHRNB1 CHRNB2 CHRNB3

8.61e-06271114CID000000412
Drugpozanicline

CHRNA5 CHRNB1 CHRNB2

9.27e-0691113ctd:C108326
Drugbromoacetylcholine bromide

CHRNA2 CHRNB1 CHRNB2 CHRNB3

1.16e-05291114CID000204966
Drugotenzepad

CHRNA2 CHRNB1 CHRNB2 CHRNB3 BRI3

1.20e-05611115CID000107867
Drugtetrahydrodeoxycortisol

ELP1 CHRNA2 CHRNB1 CHRNB2

1.52e-05311114CID000010593
DrugAC1L1JK6

CHRNA2 CHRNB1 CHRNB2 CHRNB3

1.52e-05311114CID000005077
Drugtropicamide

CHRNA2 CHRNB1 CHRNB2 CHRNB3

1.73e-05321114CID000005593
Drugbenzilate

CHRNA2 CHRNB1 CHRNB3 CACNA2D4 BRI3

1.77e-05661115CID000201538
DrugDns-C6-Cho

CHRNA2 CHRNB1 CHRNB3

1.81e-05111113CID000124728
DrugAC1L9NC9

CHRNA2 CHRNB1 CHRNB3

1.81e-05111113CID000449642
Drugcytisine

CHRNA2 CHRNA5 CHRNB2

1.81e-05111113ctd:C004712
Drugdihydronereistoxin

CHRNA2 CHRNB1 CHRNB3

1.81e-05111113CID000121232
DrugLJP 1082

CHRNA2 CHRNB1 CHRNB3

1.81e-05111113CID003037609
Drugbipinnatin-B

CHRNA2 CHRNB1 CHRNB3

1.81e-05111113CID000127363
Drugmethamidophos

CHRNA2 CHRNB1 CHRNB2 CHRNB3

1.96e-05331114CID000004096
Drugdecamethonium

CHRNA2 CHRNB1 CHRNB2 CHRNB3

1.96e-05331114CID000002968
Drugcytisine

CHRNA2 CHRNB1 CHRNB2 CHRNB3

1.96e-05331114CID000010235
DrugGTS-21

CHRNA2 CHRNB1 CHRNB2 CHRNB3

2.22e-05341114CID005310985
Drugl-Lobeline

CHRNA2 CHRNB1 CHRNB2 CHRNB3

2.22e-05341114CID000003945
Drugthiacloprid

CHRNA2 CHRNB1 CHRNB2 CHRNB3

2.22e-05341114CID000115224
DrugND-186

TRIM39 DBH

2.36e-0521112CID000173872
Drugtrifluoropentoxypicolinic acid

TRIM39 DBH

2.36e-0521112CID000156082
DrugAC1L9P8C

CHRNA2 CHRNB1 CHRNB3

2.40e-05121113CID000450864
DrugSureCN373116

CHRNA2 CHRNB1 CHRNB3

2.40e-05121113CID010085732
Drug(+/-)-Epibatidine

CHRNA2 CHRNB1 CHRNB2 CHRNB3

2.49e-05351114CID000001204
Drugatracurium

CHRNA2 CHRNB1 CHRNB2 CHRNB3

2.49e-05351114CID000047319
DrugEPTC

CHRNA2 CHRNB1 CHRNB2 CHRNB3

2.49e-05351114CID000012968
DrugPhTX-343

CHRNA2 CHRNB1 CHRNB2 CHRNB3

2.79e-05361114CID000159548
Drugnereistoxin

CHRNA2 CHRNB1 CHRNB3

3.11e-05131113CID000015401
Drug1-acetyl-4-methylpiperazine methiodide

CHRNA2 CHRNB1 CHRNB3

3.11e-05131113CID004392675
DrugC-toxiferine-I

CHRNA2 CHRNB1 CHRNB3

3.11e-05131113CID005089093
Drugbipinnatin-A

CHRNA2 CHRNB1 CHRNB3

3.11e-05131113CID000196603
Drugbipinnatin-C

CHRNA2 CHRNB1 CHRNB3

3.11e-05131113CID000129977
DrugHHSiD

CHRNA2 CHRNB1 CHRNB3 BRI3

3.12e-05371114CID000003602
DrugO585

CHRNA2 CHRNB1 CHRNB2 CHRNB3

3.12e-05371114CID000107646
DrugNSC-293162

CHRNA2 CHRNB1 CHRNB2 CHRNB3

3.48e-05381114CID000004675
DrugAP-5

ZSWIM6 REPIN1 CHRNA2 CHRNB1 CHRNB3 CACNA2D4

3.92e-051281116CID000001216
Drug2,3-dichlorooctafluorobutane

CHRNA2 CHRNB1 CHRNB3

3.95e-05141113CID000078982
DrugLNF 209

CHRNA2 CHRNB1 CHRNB3

3.95e-05141113CID000132666
DrugAC1L1BQX

ELP1 CHRNA2 CHRNB1 CHRNB2 CHRNB3

4.25e-05791115CID000001565
Drugmethylatropine

BCLAF1 CHRNA2 CHRNB1 CHRNB3

4.27e-05401114CID000005860
Drugbupropion

CHRNA2 CHRNA5 CHRNB1 CHRNB2 CHRNB3

4.80e-05811115CID000000444
Druganatoxin-a hydrochloride

CHRNA2 CHRNB1 CHRNB3

4.92e-05151113CID000135265
DrugSAD-128

CHRNA2 CHRNB1 CHRNB3

4.92e-05151113CID000162008
DrugN-methylcytisine

CHRNA2 CHRNB1 CHRNB3

4.92e-05151113CID000234566
Drugaa373

CHRNA2 CHRNB1 CHRNB3

4.92e-05151113CID000191672
DrugThyroxine (L) [51-48-9]; Down 200; 5.2uM; HL60; HT_HG-U133A

MAZ DCLRE1B ZKSCAN5 NFIC ZFYVE26 PARPBP NOTCH2

5.02e-0519611171312_DN
DrugN-methylscopolamine

CHRNA2 CHRNB1 CHRNB2 CHRNB3

5.19e-05421114CID000004120
DrugQX-222

CHRNA2 CHRNB1 CHRNB2 CHRNB3

5.19e-05421114CID000005014
Druggallamin

CHRNA2 CHRNB1 CHRNB2 CHRNB3

5.70e-05431114CID000067425
DrugHexamethonium

CHRNA2 CHRNA5 CHRNB2

6.03e-05161113ctd:D018738
Drug3-(trifluoromethyl)-3-(m-iodophenyl)diazirine

CHRNA2 CHRNB1 CHRNB3

6.03e-05161113CID000123866
Drugbenzoquinonium

CHRNA2 CHRNB1 CHRNB3

6.03e-05161113CID000009393
DrugPNU-282,987

CHRNA2 CHRNB1 CHRNB3

6.03e-05161113CID004655349
Drugdihydro-beta-erythroidine

CHRNA2 CHRNB1 CHRNB2 CHRNB3

6.25e-05441114CID000031762
Drugsazetidine-A

CHRNA2 CHRNB2

7.04e-0531112ctd:C514816
DrugNsc36388

CHRNA2 CHRNB1 CHRNB3

7.30e-05171113CID000014954
Diseasecongenital myasthenic syndrome (implicated_via_orthology)

CHRNA2 CHRNB1 CHRNB2 CHRNB3

2.77e-07161064DOID:3635 (implicated_via_orthology)
Diseasealcohol use disorder (implicated_via_orthology)

DBH JMJD1C CHRNA2 CHRNB1 CHRNB2 CHRNB3 NOTCH2

6.93e-061951067DOID:1574 (implicated_via_orthology)
Diseasesmoking cessation

ZBTB20 MCM2 DBH JMJD1C CHRNA2 CHRNA5 CHRNB3 NLGN2

2.35e-053251068EFO_0004319
DiseaseAutosomal dominant nocturnal frontal lobe epilepsy

CHRNA2 CHRNB2

7.63e-0541062cv:C3696898
Diseaseneutrophil count

SCFD2 DCLRE1B ZMIZ1 PTGFRN ZKSCAN5 GLCCI1 JMJD1C CHRNB2 HIVEP3 CLK2 BEND7 ZNF398 BRI3 TNR NOTCH2

1.25e-04138210615EFO_0004833
Diseasepost-operative atrial fibrillation, response to surgery

ZBTB20 C13orf42

1.27e-0451062EFO_0009951, EFO_0009952
Diseasenicotine dependence

DBH CHRNA5 CHRNB2 CHRNB3

1.83e-04781064EFO_0003768
Diseasepeptic ulcer disease

CERKL GGT1 JRK

2.27e-04331063MONDO_0004247
DiseaseAutosomal Dominant Nocturnal Frontal Lobe Epilepsy

CHRNA2 CHRNB2

2.65e-0471062C3696898
Diseaseaflatoxins-related hepatocellular carcinoma (biomarker_via_orthology)

GGT2P GGT1

2.65e-0471062DOID:5022 (biomarker_via_orthology)
Diseasealcohol dependence (biomarker_via_orthology)

GGT2P GGT1

3.53e-0481062DOID:0050741 (biomarker_via_orthology)
DiseaseAlcoholic Intoxication, Chronic

GOLM2 DBH ZNF699 CHRNA5 GGT1 CHRNB3

4.24e-042681066C0001973
Diseasetime to first cigarette measurement

CHRNA5 CHRNB3

4.53e-0491062EFO_0010126
Diseasemyeloid white cell count

SCFD2 ZKSCAN5 GLCCI1 JMJD1C HIVEP3 BEND7 ZNF398 BRI3 TNR NOTCH2 PARP12

5.58e-0493710611EFO_0007988
Diseaseesophagus squamous cell carcinoma (is_implicated_in)

CHRNA5 FAT1 EFNB2

5.73e-04451063DOID:3748 (is_implicated_in)
DiseaseTOBACCO ADDICTION, SUSCEPTIBILITY TO (finding)

CHRNA5 CHRNB3

8.24e-04121062C1861063
Diseaseautism spectrum disorder (implicated_via_orthology)

ABCA3 CHRNB2 TAOK2 NLGN2

2.24e-031521064DOID:0060041 (implicated_via_orthology)
Diseaseesophagus squamous cell carcinoma (is_marker_for)

CHRNA5 FAT1 EFNB2

2.43e-03741063DOID:3748 (is_marker_for)
Diseasegastric ulcer

GGT1 JRK

2.57e-03211062EFO_0009454
Diseasecolorectal carcinoma (is_implicated_in)

PTPRB EFNB2

2.82e-03221062DOID:0080199 (is_implicated_in)
Diseasetriacylglycerol 54:8 measurement

CACNA2D4 FCMR

3.08e-03231062EFO_0010426
Diseasetobacco smoke exposure measurement

DBH CHRNB3

3.35e-03241062EFO_0009115

Protein segments in the cluster

PeptideGeneStartEntry
EITGTHHHTRLIFVF

nan

26

Q8N976
TQTSHLPESERIHHT

ACIN1

751

Q9UKV3
FVINVHHRSSSTYHP

CHRNB3

316

Q05901
YLHHTINLTHSLPAA

nan

41

Q9N2J8
THHPRVYNIHSRTVT

BRI3

51

O95415
EHHSTIVSTRHYRAP

CLK2

336

P49760
HVQAPFTSATHLEHV

ARFGEF1

931

Q9Y6D6
PHHTSLVVYHVAVTL

GPR20

271

Q99678
HQTHQTSLQYRHPTS

CCNJ

281

Q5T5M9
PRRHSEDIAAHTVHT

C13orf42

206

A0A1B0GVH6
TVFVLNVHHRSPSTH

CHRNA2

346

Q15822
LVHHHVPNATLESSA

ABCA3

776

Q99758
SVVVLNLHHRSPHTH

CHRNB1

326

P11230
RQSPLHGNHITISHT

GLCCI1

256

Q86VQ1
VHQAPDTQSISHFLH

AHDC1

646

Q5TGY3
LQSVHHPESRSSIQH

CLSTN2

811

Q9H4D0
SPITAHLLHRHLQVS

DCLRE1B

51

Q9H816
HSVLPLLLTTSHHNA

DMXL1

646

Q9Y485
FHHLIPAHTFTNIST

EEPD1

466

Q7L9B9
VHPSHHDTAVLITRE

ADAMTS20

346

P59510
TVSYSLPINNTHIHH

ADAMTS6

226

Q9UKP5
TISPNSHFHVATHNR

PCDHB5

171

Q9Y5E4
NTIHHHGTSILTLFR

PARPBP

381

Q9NWS1
ARFVVGSHVRHHPSN

MCM2

676

P49736
THSTARLSFVTPRHH

FAT1

3761

Q14517
TVLPSVSQLLSHHHI

NOTCH2

2216

Q04721
VSQLLSHHHIVSPGS

NOTCH2

2221

Q04721
SQTIPKHVFEHTFHR

PTPRB

951

P23467
THHANHALPVYVFTR

HYAL2

281

Q12891
SHAPTGSSVHNILHI

LIPN

281

Q5VXI9
AILHSSPESASHQLH

LZTS1

136

Q9Y250
PLHVQSHLYSHLSSI

M1AP

441

Q8TC57
HAAAYTTHPSTLVHQ

HIPK1

1141

Q86Z02
RHQVPRAEISHHISS

GTSF1

56

Q8WW33
RIHPTATHHITNEGV

HMCN2

976

Q8NDA2
RSHSITIDFTHPCHV

KATNIP

1056

O60303
LHPHRQRHFITSSSS

LRRC53

516

A6NM62
HLPHQIASHSVTTFR

JMJD1C

1166

Q15652
HRKHSPQHTTTLSLS

EFNB2

256

P52799
ASQPTSTIILHSHHL

ERAP1

86

Q9NZ08
FHHIFVPSVREHFRT

JRK

271

O75564
HLNSHVRQVHSTERP

MAZ

351

P56270
TARPSQFPHSLHLHS

TUBGCP5

226

Q96RT8
AVSHSEFSPRSVIHH

ELP1

516

O95163
NIHSIHFSGHVFTVR

F8

1971

P00451
HSLTTEHNLSVLRTH

PARP12

116

Q9H0J9
ISPNSHFHILTRNHS

PCDHB4

171

Q9Y5E5
LHPAPTSLSHTFHRA

FRMD1

496

Q8N878
TVFAINIHHRSSSTH

CHRNA5

331

P30532
FIHNPHTRNQHVSAS

BBS2

41

Q9BXC9
HLIHFVQVQPSHTRT

C3orf84

126

H3BNL1
HHHSAAQPLVSPISA

CACNA2D4

946

Q7Z3S7
TSESFIQHIVSLVHH

BCLAF1

601

Q9NYF8
HILHPTHSQALAVLS

CDON

221

Q4KMG0
PSGIHIFASQLHTHL

DBH

401

P09172
THQPVAIHPSSVLFH

DHX33

646

Q9H6R0
STNVLAHSLHGVPHV

CERKL

301

Q49MI3
HSFLITQVSATLHHQ

BEND7

481

Q8N7W2
RHFSNHATHVEFLPV

DDHD1

441

Q8NEL9
PHLHNLHTELFTTTT

NLGN2

606

Q8NFZ4
ALETRHHHTQIASTF

GGT2P

526

P36268
NQTSVSHFILVGLHH

OR10G6

26

Q8NH81
DHAHHVKFSSSVPQR

NRK

796

Q7Z2Y5
RDSLVHSSPHVALSH

PTGFRN

336

Q9P2B2
HSSPHVALSHVDARS

PTGFRN

341

Q9P2B2
VSQHESHQAISHLPT

GOLM2

276

Q6P4E1
HAHVNSRISVHSPLD

RTTN

341

Q86VV8
QSPALHRAAAHIHSS

SZT2

1716

Q5T011
QPHHEGRSLSHIFTF

SPATA48

196

A4D263
HTHDVRTVAHSPTAL

UTP4

286

Q969X6
ISHTHRAHTVVPLDD

TRIM39

131

Q9HCM9
NPVHSHIGATVSHQT

RESF1

126

Q9HCM1
IAQHSHSPHCTVSIV

PKDREJ

1066

Q9NTG1
LQHRVHSVGHFPVSI

SLAIN1

456

Q8ND83
SSAHVALQVHPHCTV

SHARPIN

236

Q9H0F6
EHTVTSHSSIIHRLP

TAOK2

406

Q9UL54
SLHSESLHPTVFVQH

SPATA31D4

506

Q6ZUB0
TVSHAVHLTANHVPA

SCFD2

106

Q8WU76
LSSFTQHHRPVIAVH

NFIC

346

P08651
HQGFQHLVHSLTVPS

SERPINA9

111

Q86WD7
THLVAHSRVHSGERP

REPIN1

416

Q9BWE0
VCVLNVHHRSPTTHT

CHRNB2

316

P17787
SFSNTSHLIIHERTH

ZNF572

196

Q7Z3I7
SLHSESLHPTVFVQH

SPATA31D3

506

P0C874
NTTHSRLTHISPRHY

ZSWIM5

1121

Q9P217
PVFQHHTSHTVRQSR

ZNF565

186

Q8N9K5
ITTIHHTFLQHFAVS

ZNF804B

1206

A4D1E1
FHSLSSFQVHERIHT

ZNF136

261

P52737
FHSLSPFRIHERTHT

ZNF136

401

P52737
SATLAVHHRTHLEPA

ZNF691

211

Q5VV52
VFNHPSTLRSHVSIH

ZNF177

156

Q13360
FHTSYHSQAVHIRPV

PIGT

211

Q969N2
AFHSQISSHATSHPV

RNF111

691

Q6ZNA4
SLLSQFSHHHVVVFL

SLC37A3

11

Q8NCC5
ADHRVHQVTPQTHFI

PITHD1

196

Q9GZP4
RSHHSISSQTFEHPL

RLIM

241

Q9NVW2
TFTHPSRLTYHLRVH

ZNF398

406

Q8TD17
SPHILQIHLSTHFRE

ZBTB18

381

Q99592
HLVTHQRTHTGERPF

ZNF774

361

Q6NX45
HTGVIPTHHQFITNE

SORBS1

761

Q9BX66
HHSSPTTQITHRPRV

FCMR

176

O60667
PISHLHFSHVTSSSV

TNR

776

Q92752
EALSHSSHVFTSHPR

HIVEP3

571

Q5T1R4
IFSHLPLHSQHLTRA

HIVEP3

2176

Q5T1R4
QTSHERPTDVAHSHL

TANGO6

781

Q9C0B7
LAHVRSFTPHQQAHI

SYMPK

1076

Q92797
PALIHSTHSLTNSHA

ZBTB20

46

Q9HC78
SSSAHPFISNLHTRH

ZNF839

106

A8K0R7
NTTHSRLTHISPRHY

ZSWIM6

1151

Q9HCJ5
VEHLVSHHSPQRTES

ZNF362

396

Q5T0B9
FSHPSDLVRHQRIHT

ZNF212

436

Q9UDV6
FSQSSHLVPHQRIHT

ZNF594

276

Q96JF6
TFSRSTHLIEHQGIH

ZNF883

161

P0CG24
AFISSSHLTVHIRTH

ZNF699

511

Q32M78
KFRSSTQLHELTPHH

SMC5

976

Q8IY18
TFSLPSLFHRHERTH

ZNF433

486

Q8N7K0
SHSVLYTLHHLTNLP

ZFYVE26

441

Q68DK2
FCLQTSLTLHHRIHP

ZNF850

151

A8MQ14
FRVSSHLVQHHSVHS

ZKSCAN5

411

Q9Y2L8
HNLAVSNHVFHLRPT

ZMIZ1

581

Q9ULJ6
SNHVFHLRPTVHQTL

ZMIZ1

586

Q9ULJ6
ALETRHHHTQIASTF

GGT1

526

P19440