Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionextracellular matrix structural constituent

COL9A2 VWF PXDN LAMA4 SRPX MUC2 SSPOP MUC5AC

1.16e-07188628GO:0005201
GeneOntologyMolecularFunctionH3K27me3 modified histone binding

TAF1 TAF1L

9.43e-055622GO:0061628
GeneOntologyMolecularFunctioncomplement binding

CR2 MASP2 CFHR4

1.33e-0432623GO:0001848
GeneOntologyMolecularFunctionRNA polymerase I general transcription initiation factor activity

TAF1 TAF1L

3.37e-049622GO:0001181
GeneOntologyMolecularFunctionstructural molecule activity

COL9A2 VWF PXDN SPRR3 LAMA4 SRPX ERVK-24 MUC2 SSPOP MUC5AC

3.88e-048916210GO:0005198
GeneOntologyMolecularFunctiondipeptidyl-peptidase activity

DPP9 DPP8

6.14e-0412622GO:0008239
GeneOntologyMolecularFunctionhigh voltage-gated calcium channel activity

CACNA1C CACNA1I

8.43e-0414622GO:0008331
GeneOntologyBiologicalProcesscell-matrix adhesion

ADAMTS12 PTPN11 PTPRK ADAM15 ADAMTS13 ZYX SVEP1

1.62e-05270627GO:0007160
GeneOntologyBiologicalProcesscell-substrate adhesion

ADAMTS12 PTPN11 VWF PTPRK ADAM15 ADAMTS13 ZYX SVEP1

3.01e-05410628GO:0031589
GeneOntologyBiologicalProcesscomplement activation

CR2 SVEP1 MASP2 CFHR4

5.85e-0570624GO:0006956
GeneOntologyBiologicalProcessregulation of complement activation

CR2 SVEP1 CFHR4

7.19e-0527623GO:0030449
GeneOntologyCellularComponentextracellular matrix

ADAMTS12 SSC5D COL9A2 VWF PXDN LAMA4 ADAMTS13 SRPX GDF10 MUC2 SSPOP MUC5AC SVEP1

6.29e-086566313GO:0031012
GeneOntologyCellularComponentexternal encapsulating structure

ADAMTS12 SSC5D COL9A2 VWF PXDN LAMA4 ADAMTS13 SRPX GDF10 MUC2 SSPOP MUC5AC SVEP1

6.51e-086586313GO:0030312
GeneOntologyCellularComponentmucus layer

MUC2 MUC5AC

2.68e-053632GO:0070701
GeneOntologyCellularComponentcollagen-containing extracellular matrix

SSC5D COL9A2 VWF PXDN LAMA4 SRPX GDF10 MUC2 SSPOP

2.83e-05530639GO:0062023
DomainUnchr_dom_Cys-rich

VWF KCP MUC2 SSPOP MUC5AC

3.64e-1013605IPR014853
DomainC8

VWF KCP MUC2 SSPOP MUC5AC

3.64e-1013605SM00832
DomainTIL_dom

VWF KCP MUC2 SSPOP MUC5AC

5.65e-1014605IPR002919
DomainVWD

VWF KCP MUC2 SSPOP MUC5AC

1.23e-0916605SM00216
DomainVWF_type-D

VWF KCP MUC2 SSPOP MUC5AC

1.23e-0916605IPR001846
DomainVWFD

VWF KCP MUC2 SSPOP MUC5AC

1.23e-0916605PS51233
DomainVWD

VWF KCP MUC2 SSPOP MUC5AC

1.23e-0916605PF00094
DomainVWFC_1

VWF PXDN KCP MUC2 SSPOP MUC5AC

1.54e-0936606PS01208
DomainVWC

VWF PXDN KCP MUC2 SSPOP MUC5AC

2.17e-0938606SM00214
DomainVWFC_2

VWF PXDN KCP MUC2 SSPOP MUC5AC

2.17e-0938606PS50184
DomainVWC_out

VWF KCP MUC2 SSPOP MUC5AC

3.24e-0919605SM00215
DomainVWF_dom

VWF PXDN KCP MUC2 SSPOP MUC5AC

4.08e-0942606IPR001007
DomainSushi

SRPX CR2 SEZ6L2 SVEP1 MASP2 CFHR4

1.54e-0852606PF00084
DomainCCP

SRPX CR2 SEZ6L2 SVEP1 MASP2 CFHR4

1.95e-0854606SM00032
DomainSUSHI

SRPX CR2 SEZ6L2 SVEP1 MASP2 CFHR4

2.44e-0856606PS50923
DomainSushi_SCR_CCP_dom

SRPX CR2 SEZ6L2 SVEP1 MASP2 CFHR4

2.72e-0857606IPR000436
DomainTIL

VWF MUC2 SSPOP MUC5AC

4.67e-0812604PF01826
DomainC8

VWF MUC2 SSPOP MUC5AC

4.67e-0812604PF08742
DomainCTCK_1

VWF MUC2 SSPOP MUC5AC

2.85e-0718604PS01185
DomainCys_knot_C

VWF MUC2 SSPOP MUC5AC

1.16e-0625604IPR006207
DomainCTCK_2

VWF MUC2 SSPOP MUC5AC

1.16e-0625604PS01225
DomainVWC

VWF PXDN KCP MUC5AC

1.86e-0628604PF00093
DomainTAF_II_230-bd

TAF1 TAF1L

1.01e-052602IPR009067
DomainTFIID_sub1_DUF3591

TAF1 TAF1L

1.01e-052602IPR022591
Domain-

TAF1 TAF1L

1.01e-0526021.10.1100.10
DomainBMP3/BMP3B

BMP3 GDF10

1.01e-052602IPR017197
DomainTBP-binding

TAF1 TAF1L

1.01e-052602PF09247
DomainDUF3591

TAF1 TAF1L

1.01e-052602PF12157
DomainTAF1_animal

TAF1 TAF1L

1.01e-052602IPR011177
DomainHYR

SRPX SVEP1

3.04e-053602PS50825
DomainHYR

SRPX SVEP1

3.04e-053602PF02494
DomainHYR_dom

SRPX SVEP1

3.04e-053602IPR003410
DomainCT

VWF MUC2 MUC5AC

4.65e-0522603SM00041
DomainTSP_1

ADAMTS12 THSD7A ADAMTS13 SSPOP

4.97e-0563604PF00090
DomainTSP1

ADAMTS12 THSD7A ADAMTS13 SSPOP

5.63e-0565604SM00209
DomainTSP1_rpt

ADAMTS12 THSD7A ADAMTS13 SSPOP

5.63e-0565604IPR000884
DomainTSP1

ADAMTS12 THSD7A ADAMTS13 SSPOP

5.63e-0565604PS50092
Domain-

DPP9 DPP8

1.51e-0466022.140.10.30
DomainDPPIV_N

DPP9 DPP8

1.51e-046602PF00930
DomainWxxW_domain

MUC2 MUC5AC

1.51e-046602IPR025155
DomainMucin2_WxxW

MUC2 MUC5AC

1.51e-046602PF13330
DomainPeptidase_S9B_N

DPP9 DPP8

1.51e-046602IPR002469
DomainDISINTEGRIN_1

ADAMTS12 ADAM15 ADAMTS13

2.86e-0440603PS00427
DomainReprolysin

ADAMTS12 ADAM15 ADAMTS13

2.86e-0440603PF01421
DomainADAM_MEPRO

ADAMTS12 ADAM15 ADAMTS13

2.86e-0440603PS50215
DomainDISINTEGRIN_2

ADAMTS12 ADAM15 ADAMTS13

2.86e-0440603PS50214
DomainPeptidase_M12B

ADAMTS12 ADAM15 ADAMTS13

2.86e-0440603IPR001590
DomainDisintegrin_dom

ADAMTS12 ADAM15 ADAMTS13

3.08e-0441603IPR001762
DomainPept_M10_metallopeptidase

ADAMTS12 ADAM15 ADAMTS13

3.55e-0443603IPR001818
DomainVDCCAlpha1

CACNA1C CACNA1I

4.49e-0410602IPR002077
DomainPeptidase_S9

DPP9 DPP8

5.48e-0411602PF00326
DomainPeptidase_S9

DPP9 DPP8

5.48e-0411602IPR001375
DomainCUB

ADAMTS13 SEZ6L2 MASP2

6.59e-0453603PS01180
DomainCUB_dom

ADAMTS13 SEZ6L2 MASP2

8.15e-0457603IPR000859
DomainEGF_1

ADAM15 LAMA4 SSPOP SVEP1 MASP2

1.35e-03255605PS00022
DomainMetalloPept_cat_dom

ADAMTS12 ADAM15 ADAMTS13

2.25e-0381603IPR024079
Domain-

ADAMTS12 ADAM15 ADAMTS13

2.25e-03816033.40.390.10
DomainPeptidase_M12B_ADAM-TS

ADAMTS12 ADAMTS13

2.68e-0324602IPR013273
DomainEphrin_rec_like

TNFRSF21 SVEP1

2.90e-0325602SM01411
DomainTyr-kin_ephrin_A/B_rcpt-like

TNFRSF21 SVEP1

2.90e-0325602IPR011641
DomainBromodomain_CS

TAF1 TAF1L

3.14e-0326602IPR018359
DomainACR

ADAM15 ADAMTS13

3.38e-0327602SM00608
DomainADAM_Cys-rich

ADAM15 ADAMTS13

3.38e-0327602IPR006586
DomainTGFb_propeptide

BMP3 GDF10

3.64e-0328602PF00688
DomainTGF-b_N

BMP3 GDF10

3.64e-0328602IPR001111
DomainZINC_PROTEASE

ADAMTS12 ADAM15 ADAMTS13

3.86e-0398603PS00142
DomainTGF-beta-rel

BMP3 GDF10

4.73e-0332602IPR015615
DomainTGFb_CS

BMP3 GDF10

4.73e-0332602IPR017948
DomainPTPc

PTPN11 PTPRK

5.96e-0336602SM00194
DomainTGFB

BMP3 GDF10

6.29e-0337602SM00204
DomainTGF-b_C

BMP3 GDF10

6.29e-0337602IPR001839
DomainBROMODOMAIN_1

TAF1 TAF1L

6.29e-0337602PS00633
DomainTGF_BETA_2

BMP3 GDF10

6.29e-0337602PS51362
DomainTGF_beta

BMP3 GDF10

6.29e-0337602PF00019
DomainTGF_BETA_1

BMP3 GDF10

6.29e-0337602PS00250
PathwayREACTOME_O_LINKED_GLYCOSYLATION

ADAMTS12 THSD7A ADAMTS13 MUC2 SSPOP MUC5AC

5.77e-07109406MM15164
PathwayREACTOME_DISEASES_ASSOCIATED_WITH_O_GLYCOSYLATION_OF_PROTEINS

ADAMTS12 THSD7A ADAMTS13 SSPOP MUC5AC

1.30e-0668405M27303
PathwayREACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS

ADAMTS12 THSD7A ADAMTS13 SSPOP

4.25e-0639404M27417
PathwayREACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS

ADAMTS12 THSD7A ADAMTS13 SSPOP

4.25e-0639404MM15165
PathwayREACTOME_O_LINKED_GLYCOSYLATION

ADAMTS12 THSD7A ADAMTS13 SSPOP MUC5AC

1.46e-05111405M27416
PathwayREACTOME_NCAM_SIGNALING_FOR_NEURITE_OUT_GROWTH

CACNA1C COL9A2 HRAS CACNA1I

2.93e-0563404M11187
PathwayREACTOME_DISEASES_OF_GLYCOSYLATION

ADAMTS12 THSD7A ADAMTS13 SSPOP MUC5AC

4.95e-05143405M27275
PathwayREACTOME_DEFECTS_OF_PLATELET_ADHESION_TO_EXPOSED_COLLAGEN

VWF ADAMTS13

2.17e-048402M48236
PathwayREACTOME_NCAM1_INTERACTIONS

CACNA1C COL9A2 CACNA1I

2.25e-0442403M7169
PathwayWP_IL11_SIGNALING

PTPN11 PIAS3 HRAS

2.59e-0444403M39716
PathwayWP_MECP2_AND_ASSOCIATED_RETT_SYNDROME

MYT1 TAF1 TAF1L

2.95e-0446403MM15949
PathwayREACTOME_SIGNALING_BY_EGFR

PTPN11 PTPRK HRAS

3.56e-0449403MM14695
PathwayREACTOME_ACTIVATED_NTRK2_SIGNALS_THROUGH_FRS2_AND_FRS3

PTPN11 HRAS

4.25e-0411402M27911
PathwayREACTOME_SIGNALING_BY_EGFR

PTPN11 PTPRK HRAS

4.49e-0453403M27039
PathwayREACTOME_PLATELET_ADHESION_TO_EXPOSED_COLLAGEN

VWF ADAMTS13

5.09e-0412402MM15452
PathwayREACTOME_SIGNALING_BY_PDGF

COL9A2 PTPN11 HRAS

5.57e-0457403MM14713
PathwayREACTOME_SIGNALING_BY_PDGF

COL9A2 PTPN11 HRAS

5.86e-0458403M2049
PathwayWP_COMPLEMENT_AND_COAGULATION_CASCADES

VWF CR2 MASP2

5.86e-0458403M39649
PathwayWP_DENGUE2_INTERACTIONS_WITH_COMPLEMENT_AND_COAGULATION_CASCADES

VWF CR2 MASP2

6.16e-0459403M48343
PathwayREACTOME_DISEASES_OF_METABOLISM

ADAMTS12 THSD7A ADAMTS13 SSPOP MUC5AC

6.68e-04250405M27554
PathwayREACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION

COL9A2 VWF PXDN ADAM15 LAMA4

7.70e-04258405MM14572
PathwayWP_ONCOSTATIN_M_SIGNALING

PTPN11 PIAS3 HRAS

8.18e-0465403M39562
PathwayREACTOME_SIGNALING_BY_MET

PTPN11 HRAS LAMA4

8.94e-0467403MM15345
PathwayREACTOME_PLATELET_ADHESION_TO_EXPOSED_COLLAGEN

VWF ADAMTS13

9.19e-0416402M9450
PathwayREACTOME_SIGNALING_BY_FLT3_ITD_AND_TKD_MUTANTS

PTPN11 HRAS

9.19e-0416402M41733
PathwayKEGG_COMPLEMENT_AND_COAGULATION_CASCADES

VWF CR2 MASP2

9.74e-0469403M16894
PathwayBIOCARTA_PML_PATHWAY

SP100 HRAS

1.04e-0317402M4891
PathwayREACTOME_TIE2_SIGNALING

PTPN11 HRAS

1.04e-0317402MM14836
PathwayWP_EGFEGFR_SIGNALING

PTPN11 PXDN PIAS3 HRAS

1.11e-03162404M39334
PathwayBIOCARTA_PML_PATHWAY

SP100 HRAS

1.17e-0318402MM1474
PathwayBIOCARTA_MPR_PATHWAY

MYT1 HRAS

1.17e-0318402MM1407
PathwayREACTOME_TIE2_SIGNALING

PTPN11 HRAS

1.17e-0318402M11932
PathwayWP_PROLACTIN_SIGNALING

PTPN11 PIAS3 HRAS

1.29e-0376403M39601
PathwayREACTOME_DISEASES_OF_HEMOSTASIS

VWF ADAMTS13

1.30e-0319402M48230
PathwayREACTOME_FRS_MEDIATED_FGFR3_SIGNALING

PTPN11 HRAS

1.30e-0319402MM15245
PathwayREACTOME_SIGNALING_BY_MET

PTPN11 HRAS LAMA4

1.44e-0379403M27643
PathwayREACTOME_FRS_MEDIATED_FGFR3_SIGNALING

PTPN11 HRAS

1.44e-0320402M27519
PathwayREACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION

COL9A2 VWF PXDN ADAM15 LAMA4

1.51e-03300405M610
PathwayKEGG_MEDICUS_REFERENCE_ACH_CHRN_RAS_ERK_SIGNALING_PATHWAY

HRAS ATF6B

1.59e-0321402M47792
PathwayREACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS

MUC2 MUC5AC

1.59e-0321402MM15706
PathwayBIOCARTA_IGF1_PATHWAY

PTPN11 HRAS

1.59e-0321402M2623
PathwayBIOCARTA_MPR_PATHWAY

MYT1 HRAS

1.59e-0321402M13883
PathwayBIOCARTA_IL6_PATHWAY

PTPN11 HRAS

1.59e-0321402M5489
PathwayREACTOME_FRS_MEDIATED_FGFR4_SIGNALING

PTPN11 HRAS

1.59e-0321402MM15248
PathwayBIOCARTA_INSULIN_PATHWAY

PTPN11 HRAS

1.59e-0321402M765
PathwayREACTOME_COMPLEMENT_CASCADE

CR2 MASP2 CFHR4

1.72e-0384403MM14653
PathwayREACTOME_FRS_MEDIATED_FGFR4_SIGNALING

PTPN11 HRAS

1.75e-0322402M27522
PathwayBIOCARTA_IGF1_PATHWAY

PTPN11 HRAS

1.75e-0322402MM1409
PathwayBIOCARTA_IL6_PATHWAY

PTPN11 HRAS

1.75e-0322402MM1415
PathwayREACTOME_FRS_MEDIATED_FGFR1_SIGNALING

PTPN11 HRAS

1.75e-0322402MM15239
PathwayREACTOME_FRS_MEDIATED_FGFR1_SIGNALING

PTPN11 HRAS

1.91e-0323402M27513
PathwayKEGG_MEDICUS_REFERENCE_E2_ER_RAS_ERK_SIGNALING_PATHWAY

HRAS ATF6B

1.91e-0323402M47799
PathwayKEGG_MEDICUS_REFERENCE_VGCC_CA2_APOPTOTIC_PATHWAY

CACNA1C CACNA1I

1.91e-0323402M47666
PathwayREACTOME_FRS_MEDIATED_FGFR2_SIGNALING

PTPN11 HRAS

1.91e-0323402MM15243
PathwayBIOCARTA_INSULIN_PATHWAY

PTPN11 HRAS

2.08e-0324402MM1425
PathwayREACTOME_DOWNSTREAM_SIGNALING_OF_ACTIVATED_FGFR3

PTPN11 HRAS

2.08e-0324402MM15246
PathwayBIOCARTA_TFF_PATHWAY

HRAS MUC2

2.08e-0324402M15926
PathwayREACTOME_FRS_MEDIATED_FGFR2_SIGNALING

PTPN11 HRAS

2.26e-0325402M27517
PathwayREACTOME_DOWNSTREAM_SIGNALING_OF_ACTIVATED_FGFR3

PTPN11 HRAS

2.26e-0325402M27520
PathwayREACTOME_SIGNALING_BY_NTRK2_TRKB

PTPN11 HRAS

2.26e-0325402M27864
PathwayKEGG_MEDICUS_REFERENCE_CA2_ENTRY_VOLTAGE_GATED_CA2_CHANNEL

CACNA1C CACNA1I

2.26e-0325402M47948
PathwayWP_FOCAL_ADHESION

VWF HRAS LAMA4 ZYX

2.37e-03199404M39402
PathwayKEGG_FOCAL_ADHESION

VWF HRAS LAMA4 ZYX

2.37e-03199404M7253
PathwayREACTOME_DOWNSTREAM_SIGNALING_OF_ACTIVATED_FGFR4

PTPN11 HRAS

2.44e-0326402MM15249
PathwayWP_COMPLEMENT_SYSTEM

CR2 MASP2 CFHR4

2.52e-0396403M39581
PathwayWP_PI3KAKT_SIGNALING

COL9A2 VWF HRAS LAMA4 ATF6B

2.57e-03339405M39736
PathwayWP_B_CELL_RECEPTOR_SIGNALING

PTPN11 HRAS CR2

2.59e-0397403M39323
PathwayREACTOME_DOWNSTREAM_SIGNALING_OF_ACTIVATED_FGFR4

PTPN11 HRAS

2.63e-0327402M27523
PathwayREACTOME_DOWNSTREAM_SIGNAL_TRANSDUCTION

PTPN11 HRAS

2.63e-0327402MM14712
PathwayREACTOME_FLT3_SIGNALING_IN_DISEASE

PTPN11 HRAS

2.83e-0328402M41724
PathwayREACTOME_DOWNSTREAM_SIGNALING_OF_ACTIVATED_FGFR2

PTPN11 HRAS

2.83e-0328402MM15241
PathwayBIOCARTA_TFF_PATHWAY

HRAS MUC2

3.04e-0329402MM1522
PathwayPID_IGF1_PATHWAY

PTPN11 HRAS

3.04e-0329402M125
PathwayREACTOME_DOWNSTREAM_SIGNAL_TRANSDUCTION

PTPN11 HRAS

3.04e-0329402M779
PathwayREACTOME_DOWNSTREAM_SIGNALING_OF_ACTIVATED_FGFR2

PTPN11 HRAS

3.25e-0330402M27515
PathwayREACTOME_DOWNSTREAM_SIGNALING_OF_ACTIVATED_FGFR1

PTPN11 HRAS

3.25e-0330402MM15236
PathwayWP_PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM_IN_SENESCENCE_WP5122

IGFBP5 HRAS

3.47e-0331402M42531
PathwayREACTOME_DOWNSTREAM_SIGNALING_OF_ACTIVATED_FGFR1

PTPN11 HRAS

3.47e-0331402M27510
PathwayPID_EPO_PATHWAY

PTPN11 HRAS

3.92e-0333402M233
PathwayWP_ALPHA_6_BETA_4_SIGNALING

PTPN11 HRAS

3.92e-0333402M39503
PathwayBIOCARTA_MET_PATHWAY

PTPN11 HRAS

3.92e-0333402M19358
PathwayBIOCARTA_INTEGRIN_PATHWAY

HRAS ZYX

3.92e-0333402MM1426
PathwayBIOCARTA_MET_PATHWAY

PTPN11 HRAS

3.92e-0333402MM1494
PathwayWP_PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM_IN_SENESCENCE_WP5321

IGFBP5 HRAS

4.16e-0334402M48061
PathwayBIOCARTA_INTEGRIN_PATHWAY

HRAS ZYX

4.16e-0334402M3342
PathwayWP_HEPATOCYTE_GROWTH_FACTOR_RECEPTOR_SIGNALING

PTPN11 HRAS

4.16e-0334402M39383
PathwayREACTOME_COMPLEMENT_CASCADE

CR2 MASP2 CFHR4

4.19e-03115403M19752
PathwayKEGG_BASAL_TRANSCRIPTION_FACTORS

TAF1 TAF1L

4.40e-0335402M4864
PathwayPID_ERBB1_RECEPTOR_PROXIMAL_PATHWAY

PTPN11 HRAS

4.40e-0335402M127
Pubmed

Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c.

SSC5D VWF PXDN ADAM15 LAMA4 ATF6B SVEP1 CFHR4

1.65e-0824863824006456
Pubmed

Plasma ADAMTS13 activity and von Willebrand factor antigen and activity in patients with subarachnoid haemorrhage.

VWF ADAMTS13

3.23e-06263228102428
Pubmed

Intestinal MUC2 and gastric M1/MUC5AC in preneoplastic lesions induced by 1,2-dimethylhydrazine in rat: a sequential analysis.

MUC2 MUC5AC

3.23e-06263217203232
Pubmed

The association between the L1565 variant of von Willebrand factor and susceptibility to proteolysis by ADAMTS13.

VWF ADAMTS13

3.23e-06263217296575
Pubmed

Interrelationship between ADAMTS13 activity, von Willebrand factor, and complement activation in remission from immune-mediated trhrombotic thrombocytopenic purpura.

VWF ADAMTS13

3.23e-06263232065383
Pubmed

Protective effect of a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 haplotype on coronary artery disease.

VWF ADAMTS13

3.23e-06263227536857
Pubmed

ADAMTS13 gene deletion aggravates ischemic brain damage: a possible neuroprotective role of ADAMTS13 by ameliorating postischemic hypoperfusion.

VWF ADAMTS13

3.23e-06263219965676
Pubmed

Carboxyl terminus of ADAMTS13 directly inhibits platelet aggregation and ultra large von Willebrand factor string formation under flow in a free-thiol-dependent manner.

VWF ADAMTS13

3.23e-06263224357063
Pubmed

ADAMTS13 and Von Willebrand factor in patients undergoing hemodialysis.

VWF ADAMTS13

3.23e-06263222298244
Pubmed

Structure-activity relationship studies on isoindoline inhibitors of dipeptidyl peptidases 8 and 9 (DPP8, DPP9): is DPP8-selectivity an attainable goal?

DPP9 DPP8

3.23e-06263221711053
Pubmed

Reduced ADAMTS13 levels in patients with acute and chronic cerebrovascular disease.

VWF ADAMTS13

3.23e-06263228591212
Pubmed

Identifying natural substrates for dipeptidyl peptidases 8 and 9 using terminal amine isotopic labeling of substrates (TAILS) reveals in vivo roles in cellular homeostasis and energy metabolism.

DPP9 DPP8

3.23e-06263223519473
Pubmed

Profibrotic mechanisms of DPP8 and DPP9 highly expressed in the proximal renal tubule epithelial cells.

DPP9 DPP8

3.23e-06263233932609
Pubmed

ADAMTS13 deficiency exacerbates VWF-dependent acute myocardial ischemia/reperfusion injury in mice.

VWF ADAMTS13

3.23e-06263222983446
Pubmed

Obstetric outcomes in pregnant COVID-19 women: the imbalance of von Willebrand factor and ADAMTS13 axis.

VWF ADAMTS13

3.23e-06263235189860
Pubmed

Increased von Willebrand factor antigen and low ADAMTS13 activity are related to poor prognosis in covid-19 patients.

VWF ADAMTS13

3.23e-06263233502080
Pubmed

N-Glycans of ADAMTS13 modulate its secretion and von Willebrand factor cleaving activity.

VWF ADAMTS13

3.23e-06263218981290
Pubmed

The proximal carboxyl-terminal domains of ADAMTS13 determine substrate specificity and are all required for cleavage of von Willebrand factor.

VWF ADAMTS13

3.23e-06263215975930
Pubmed

[Application Value of Plasma vWF and ADAMTS-13 in Evaluating Postoprative Vascular Endothelial Injury and Prognosis in Children with VSD].

VWF ADAMTS13

3.23e-06263236765498
Pubmed

Amino acid residues Arg(659), Arg(660), and Tyr(661) in the spacer domain of ADAMTS13 are critical for cleavage of von Willebrand factor.

VWF ADAMTS13

3.23e-06263220075158
Pubmed

Dynamics of von Willebrand factor reactivity in sickle cell disease during vaso-occlusive crisis and steady state.

VWF ADAMTS13

3.23e-06263228457019
Pubmed

A conformation-sensitive monoclonal antibody against the A2 domain of von Willebrand factor reduces its proteolysis by ADAMTS13.

VWF ADAMTS13

3.23e-06263221779388
Pubmed

Role of chloride ions in modulation of the interaction between von Willebrand factor and ADAMTS-13.

VWF ADAMTS13

3.23e-06263215809291
Pubmed

Platelet-free shear flow assay facilitates analysis of shear-dependent functions of VWF and ADAMTS13.

VWF ADAMTS13

3.23e-06263225201004
Pubmed

Interactions of von Willebrand factor and ADAMTS13 in von Willebrand disease and thrombotic thrombocytopenic purpura.

VWF ADAMTS13

3.23e-06263225010251
Pubmed

Inhibition of SHP2-mediated dephosphorylation of Ras suppresses oncogenesis.

PTPN11 HRAS

3.23e-06263226617336
Pubmed

Von Willebrand factor and ADAMTS13: a candidate couple for preeclampsia pathophysiology.

VWF ADAMTS13

3.23e-06263221512165
Pubmed

Von Willebrand Factor, ADAMTS13 and D-Dimer Are Correlated with Different Levels of Nephropathy in Type 1 Diabetes Mellitus.

VWF ADAMTS13

3.23e-06263226168189
Pubmed

Multi-step binding of ADAMTS-13 to von Willebrand factor.

VWF ADAMTS13

3.23e-06263219765212
Pubmed

FRETS-VWF73 rather than CBA assay reflects ADAMTS13 proteolytic activity in acquired thrombotic thrombocytopenic purpura patients.

VWF ADAMTS13

3.23e-06263224740645
Pubmed

Endothelial Cell-Derived von Willebrand Factor Is the Major Determinant That Mediates von Willebrand Factor-Dependent Acute Ischemic Stroke by Promoting Postischemic Thrombo-Inflammation.

VWF ADAMTS13

3.23e-06263227444201
Pubmed

Ratio of von Willebrand factor propeptide to ADAMTS13 is associated with severity of sepsis.

VWF ADAMTS13

3.23e-06263223481506
Pubmed

Inhibition of dipeptidyl peptidase 8/9 impairs preadipocyte differentiation.

DPP9 DPP8

3.23e-06263226242871
Pubmed

Expression profiling of dipeptidyl peptidase 8 and 9 in breast and ovarian carcinoma cell lines.

DPP9 DPP8

3.23e-06263222736146
Pubmed

Altered glycosylation of platelet-derived von Willebrand factor confers resistance to ADAMTS13 proteolysis.

VWF ADAMTS13

3.23e-06263224106205
Pubmed

[Increased susceptibility of recombinant type 2A von Willebrand factor mutant A1500E to proteolysis by ADAMTS13].

VWF ADAMTS13

3.23e-06263222781599
Pubmed

Development of a severe von Willebrand factor/ADAMTS13 dysbalance during orthotopic liver transplantation.

VWF ADAMTS13

3.23e-06263219422343
Pubmed

Inflammatory cytokines inhibit ADAMTS13 synthesis in hepatic stellate cells and endothelial cells.

VWF ADAMTS13

3.23e-06263218433458
Pubmed

Variations in the ratio between von Willebrand factor and its cleaving protease during systemic inflammation and association with severity and prognosis of organ failure.

VWF ADAMTS13

3.23e-06263219190805
Pubmed

Increased plasma von Willebrand factor antigen levels but normal von Willebrand factor cleaving protease (ADAMTS13) activity in preeclampsia.

VWF ADAMTS13

3.23e-06263219190814
Pubmed

ADAMTS13 and von Willebrand factor and the risk of myocardial infarction in men.

VWF ADAMTS13

3.23e-06263217053057
Pubmed

Characterization of ADAMTS13 and von Willebrand factor levels in septic and non-septic ICU patients.

VWF ADAMTS13

3.23e-06263233606732
Pubmed

Methylation status of promoters and expression of MUC2 and MUC5AC mucins in pancreatic cancer cells.

MUC2 MUC5AC

3.23e-06263212527922
Pubmed

Mutation and ADAMTS13-dependent modulation of disease severity in a mouse model for von Willebrand disease type 2B.

VWF ADAMTS13

3.23e-06263220200350
Pubmed

von Willebrand factor-cleaving protease ADAMTS13 reduces ischemic brain injury in experimental stroke.

VWF ADAMTS13

3.23e-06263219687510
Pubmed

Intersection of mechanisms of type 2A VWD through defects in VWF multimerization, secretion, ADAMTS-13 susceptibility, and regulated storage.

VWF ADAMTS13

3.23e-06263222431572
Pubmed

Von Willebrand factor and ADAMTS13 activity in relation to risk of dementia: a population-based study.

VWF ADAMTS13

3.23e-06263229615758
Pubmed

Evidence that high von Willebrand factor and low ADAMTS-13 levels independently increase the risk of a non-fatal heart attack.

VWF ADAMTS13

3.23e-06263218194418
Pubmed

von Willebrand factor/ADAMTS13 ratio at presentation of acute ischemic brain injury is predictive of outcome.

VWF ADAMTS13

3.23e-06263231990334
Pubmed

DPP8/9 inhibition attenuates the TGF-β1-induced excessive deposition of extracellular matrix (ECM) in human mesangial cells via Smad and Akt signaling pathways.

DPP9 DPP8

3.23e-06263238458339
Pubmed

Oxidative modification of von Willebrand factor by neutrophil oxidants inhibits its cleavage by ADAMTS13.

VWF ADAMTS13

3.23e-06263219812385
Pubmed

ADAMTS-13, von Willebrand factor and related parameters in severe sepsis and septic shock.

VWF ADAMTS13

3.23e-06263217764538
Pubmed

Role of von Willebrand factor and ADAMTS-13 in early brain injury after experimental subarachnoid hemorrhage.

VWF ADAMTS13

3.23e-06263229729651
Pubmed

ADAMTS13-von Willebrand factor axis is involved in the pathophysiology of kidney ischaemia-reperfusion injury.

VWF ADAMTS13

3.23e-06263227507004
Pubmed

Recombinant CUB-1 domain polypeptide inhibits the cleavage of ULVWF strings by ADAMTS13 under flow conditions.

VWF ADAMTS13

3.23e-06263216141351
Pubmed

Change in plasma a disintegrin and metalloprotease with thrombospondin type-1 repeats-13 and von Willebrand factor levels in venous thromboembolic patients.

VWF ADAMTS13

3.23e-06263226872106
Pubmed

Keeping von Willebrand Factor under Control: Alternatives for ADAMTS13.

VWF ADAMTS13

3.23e-06263226595154
Pubmed

Domain-specific mechanical modulation of VWF-ADAMTS13 interaction.

VWF ADAMTS13

3.23e-06263231067148
Pubmed

Mechanism of von Willebrand factor scissile bond cleavage by a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 (ADAMTS13).

VWF ADAMTS13

3.23e-06263221705658
Pubmed

Insights Into Immunothrombosis: The Interplay Among Neutrophil Extracellular Trap, von Willebrand Factor, and ADAMTS13.

VWF ADAMTS13

3.23e-06263233343584
Pubmed

Zinc and calcium ions cooperatively modulate ADAMTS13 activity.

VWF ADAMTS13

3.23e-06263216286459
Pubmed

von Willebrand factor self-association is regulated by the shear-dependent unfolding of the A2 domain.

VWF ADAMTS13

3.23e-06263230936056
Pubmed

von Willebrand factor fibers promote cancer-associated platelet aggregation in malignant melanoma of mice and humans.

VWF ADAMTS13

3.23e-06263225977583
Pubmed

Effect of von Willebrand disease type 2B and type 2M mutations on the susceptibility of von Willebrand factor to ADAMTS-13.

VWF ADAMTS13

3.23e-06263217087728
Pubmed

Single particle tracking of ADAMTS13 (a disintegrin and metalloprotease with thrombospondin type-1 repeats) molecules on endothelial von Willebrand factor strings.

VWF ADAMTS13

3.23e-06263224550384
Pubmed

Impact of mutations in the von Willebrand factor A2 domain on ADAMTS13-dependent proteolysis.

VWF ADAMTS13

3.23e-06263216322474
Pubmed

The complete cDNA sequence and structural polymorphism of the polypeptide chain of porcine submaxillary mucin.

VWF MUC2

3.23e-0626329407109
Pubmed

An autoantibody epitope comprising residues R660, Y661, and Y665 in the ADAMTS13 spacer domain identifies a binding site for the A2 domain of VWF.

VWF ADAMTS13

3.23e-06263220032502
Pubmed

The ADAMTS13-von Willebrand factor axis in COVID-19 patients.

VWF ADAMTS13

3.23e-06263233230904
Pubmed

Imbalance of von Willebrand factor and its cleaving protease ADAMTS13 during systemic inflammation superimposed on advanced cirrhosis.

VWF ADAMTS13

3.23e-06263225113276
Pubmed

von Willebrand factor enhances microvesicle-induced vascular leakage and coagulopathy in mice with traumatic brain injury.

VWF ADAMTS13

3.23e-06263229941674
Pubmed

Development of a Hyperactive Primary Hemostatic System During Off-Pump Lung Transplantation Resulting From an Unbalance Between von Willebrand Factor and Its Cleaving Protease ADAMTS13.

VWF ADAMTS13

3.23e-06263225846964
Pubmed

The Role of von Willebrand Factor, ADAMTS13, and Cerebral Artery Thrombus Composition in Patient Outcome Following Mechanical Thrombectomy for Acute Ischemic Stroke.

VWF ADAMTS13

3.23e-06263229887594
Pubmed

Force-induced cleavage of single VWFA1A2A3 tridomains by ADAMTS-13.

VWF ADAMTS13

3.23e-06263219897584
Pubmed

ADAMTS13 substrate recognition of von Willebrand factor A2 domain.

VWF ADAMTS13

3.23e-06263216221672
Pubmed

Impact of the von Willebrand factor-ADAMTS-13 axis on the risk of future venous thromboembolism.

VWF ADAMTS13

3.23e-06263236736832
Pubmed

Traumatic injury results in prolonged circulation of ultralarge von Willebrand factor and a reduction in ADAMTS13 activity.

VWF ADAMTS13

3.23e-06263232441353
Pubmed

Secretion of von Willebrand Factor and Suppression of ADAMTS-13 Activity by Markedly High Concentration of Ferritin.

VWF ADAMTS13

3.23e-06263233539188
Pubmed

The p.R1819_C1948delinsS mutation makes von Willebrand factor ADAMTS13-resistant and reduces its collagen-binding capacity.

VWF ADAMTS13

3.23e-06263225904363
Pubmed

ADAMTS-13 metalloprotease interacts with the endothelial cell-derived ultra-large von Willebrand factor.

VWF ADAMTS13

3.23e-06263212775718
Pubmed

Altered von Willebrand Factor and ADAMTS13 Levels in Children With Cirrhosis and Extrahepatic Portal Hypertension.

VWF ADAMTS13

3.23e-06263233369998
Pubmed

Decreased von Willebrand factor ristocetin cofactor activity and increased ADAMTS13 antigen increase postoperative drainage after coronary artery bypass grafting.

VWF ADAMTS13

3.23e-06263224351199
Pubmed

Disulfide bond reduction of von Willebrand factor by ADAMTS-13.

VWF ADAMTS13

3.23e-06263220946172
Pubmed

Src homology 2-containing protein tyrosine phosphatase-2 acts as a negative regulator for MUC5AC transcription via the inhibition of the ERK1/2 MAPK signalling pathway in the airway.

PTPN11 MUC5AC

3.23e-06263223582017
Pubmed

Smoking, von Willebrand factor and ADAMTS-13 in healthy males.

VWF ADAMTS13

3.23e-06263223020229
Pubmed

Allosteric activation of ADAMTS13 by von Willebrand factor.

VWF ADAMTS13

3.23e-06263225512528
Pubmed

Enzymatically active ADAMTS13 variants are not inhibited by anti-ADAMTS13 autoantibodies: a novel therapeutic strategy?

VWF ADAMTS13

3.23e-06263216203734
Pubmed

ADAMTS13 controls vascular remodeling by modifying VWF reactivity during stroke recovery.

VWF ADAMTS13

3.23e-06263228428179
Pubmed

Identification of ADAMTS13 peptide sequences binding to von Willebrand factor.

VWF ADAMTS13

3.23e-06263219944670
Pubmed

ADAMTS-13 cleaves long von Willebrand factor multimeric strings anchored to endothelial cells in the absence of flow, platelets or conformation-altering chemicals.

VWF ADAMTS13

3.23e-06263218983500
Pubmed

Unconjugated bilirubin inhibits proteolytic cleavage of von Willebrand factor by ADAMTS13 protease.

VWF ADAMTS13

3.23e-06263225782102
Pubmed

Von Willebrand Factor Adhesive Activity and ADAMTS13 Protease Activity in HIV-1-Infected Men.

VWF ADAMTS13

3.23e-06263230745808
Pubmed

Mucolytic activity of bacterial and human chitinases.

MUC2 MUC5AC

3.23e-06263217321686
Pubmed

Taf1 knockout is lethal in embryonic male mice and heterozygous females show weight and movement disorders.

TAF1 TAF1L

3.23e-06263238804708
Pubmed

Activity of Von Willebrand factor and levels of VWF-cleaving protease (ADAMTS13) in preterm and full term neonates.

VWF ADAMTS13

3.23e-06263228087247
Pubmed

ADAMTS-13-VWF axis in sickle cell disease patients.

VWF ADAMTS13

3.23e-06263233404693
Pubmed

Altered expression of MUC2 and MUC5AC in progression of colorectal carcinoma.

MUC2 MUC5AC

3.23e-06263220731025
Pubmed

DP8 and DP9 have extra-enzymatic roles in cell adhesion, migration and apoptosis.

DPP9 DPP8

3.23e-06263216700509
Pubmed

A novel binding site for ADAMTS13 constitutively exposed on the surface of globular VWF.

VWF ADAMTS13

3.23e-06263219587373
Pubmed

Molecular mapping of the chloride-binding site in von Willebrand factor (VWF): energetics and conformational effects on the VWF/ADAMTS-13 interaction.

VWF ADAMTS13

3.23e-06263216899464
Cytoband11p15.5

HRAS MUC2 MUC5AC

5.87e-0411863311p15.5
Cytoband12p13.3

CACNA1C VWF

7.86e-043063212p13.3
Cytoband1q32

CR2 CFHR4

2.09e-03496321q32
GeneFamilyHyalectan proteoglycans|V-set domain containing|Sushi domain containing|C-type lectin domain containing

SRPX CR2 SEZ6L2 SVEP1 MASP2 CFHR4

4.17e-09574361179
GeneFamilyCD molecules|DASH family

DPP9 DPP8

1.15e-0474321205
GeneFamilyADAM metallopeptidases with thrombospondin type 1 motif

ADAMTS12 ADAMTS13

9.21e-041943250
GeneFamilyCD molecules|Mucins

MUC2 MUC5AC

1.13e-0321432648
GeneFamilyCalcium voltage-gated channel subunits

CACNA1C CACNA1I

1.73e-0326432253
GeneFamilyComplement system|Sushi domain containing

CR2 CFHR4

3.31e-0336432492
CoexpressionNABA_MATRISOME

ADAMTS12 BMP3 COL9A2 VWF PXDN IGFBP5 ADAM15 KCP LAMA4 ADAMTS13 SRPX GDF10 MUC2 SSPOP MUC5AC SVEP1 MASP2

1.11e-1010086217MM17056
CoexpressionNABA_MATRISOME

ADAMTS12 BMP3 COL9A2 VWF PXDN IGFBP5 ADAM15 KCP LAMA4 ADAMTS13 SRPX GDF10 MUC2 SSPOP MUC5AC SVEP1 MASP2

1.47e-1010266217M5889
CoexpressionNABA_CORE_MATRISOME

COL9A2 VWF PXDN IGFBP5 KCP LAMA4 SRPX SSPOP SVEP1

1.44e-08270629MM17057
CoexpressionNABA_ECM_GLYCOPROTEINS

VWF PXDN IGFBP5 KCP LAMA4 SRPX SSPOP SVEP1

1.66e-08191628MM17059
CoexpressionNABA_CORE_MATRISOME

COL9A2 VWF PXDN IGFBP5 KCP LAMA4 SRPX SSPOP SVEP1

1.69e-08275629M5884
CoexpressionNABA_ECM_GLYCOPROTEINS

VWF PXDN IGFBP5 KCP LAMA4 SRPX SSPOP SVEP1

2.03e-08196628M3008
CoexpressionGSE22527_ANTI_CD3_INVIVO_VS_UNTREATED_MOUSE_TREG_UP

CACNA1C SP100 CACNA1I MUC2 MUC5AC ZYX CASZ1

4.52e-07199627M7710
CoexpressionVERRECCHIA_RESPONSE_TO_TGFB1_C3

IGFBP5 LAMA4 ZYX

4.50e-0614623M5321
CoexpressionMANNO_MIDBRAIN_NEUROTYPES_HPERIC

CACNA1C PXDN PTPRK KCP LAMA4 NR4A3 SRPX TNFRSF21 ZYX SVEP1

1.61e-057956210M39050
CoexpressionBROWNE_HCMV_INFECTION_48HR_DN

CACNA1C PTPN11 IGFBP5 HRAS TAF1 GDF10 ZYX SVEP1

1.75e-05482628M12144
CoexpressionMANNO_MIDBRAIN_NEUROTYPES_HGABA

CACNA1C THSD7A RAPH1 PTPRK ASXL3 MYT1 CACNA1I SEZ6L2 MUC2 SSPOP CASZ1

5.06e-0511066211M39071
CoexpressionBRUINS_UVC_RESPONSE_LATE

CACNA1C PTPN11 PXDN PTPRK HRAS LAMA4 SRPX DPP8 SH3D21 SVEP1 TCEAL1

6.44e-0511366211M2247
CoexpressionBRUINS_UVC_RESPONSE_LATE

CACNA1C PTPN11 PXDN PTPRK HRAS LAMA4 SRPX DPP8 SH3D21 SVEP1 TCEAL1

1.03e-0411986211MM1062
CoexpressionGSE19888_NO_PRETREAT_VS_ADENOSINE_A3R_INHIBITOR_PRETREATED_MAST_CELL_TCELL_MEMBRANES_ACT_DN

PXDN DPP9 NFXL1 BAHD1 PRKRA

1.12e-04200625M7347
CoexpressionAtlasgudmap_RNAseq_e15.5_Podocytes_2500_K0

ADAMTS12 VWF THSD7A ADAM15 HRAS LAMA4 SRPX R3HDML SEZ6L2 TMEM52B ZYX CASZ1 SF3B5

1.74e-0511436113gudmap_RNAseq_e15.5_Podocytes_2500_K0
CoexpressionAtlasStromal Cells, FRC.MLN, gp38+ CD31- CD140a+, Lymph Node, avg-5

ADAMTS12 PXDN THSD7A IGFBP5 LAMA4 SRPX GDF10 SVEP1

5.38e-05466618GSM777050_500
ToppCellfacs-Mammary_Gland-Mammary_Gland-3m-Mesenchymal-stromal_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAMTS12 SSC5D SP100 LAMA4 SRPX SVEP1

2.26e-071856263cd0686a14e734a0f243070ab939adcb4c454478
ToppCellfacs-Mammary_Gland-Mammary_Gland-3m-Mesenchymal-stromal_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAMTS12 SSC5D SP100 LAMA4 SRPX SVEP1

2.26e-0718562600258f458cbf6d36449db95528a6b5038d731d2d
ToppCellfacs-Mammary_Gland-Mammary_Gland-3m-Mesenchymal|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAMTS12 SSC5D SP100 LAMA4 SRPX SVEP1

2.26e-07185626a94694e226856bc5b168464f52d76004145717a5
ToppCellfacs-Kidney-nan-3m-Mesenchymal-mesangial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAMTS12 CACNA1C BMP3 SRPX GDF10 SVEP1

2.57e-07189626a5306561026e4dfcc39beeb785e5108ac595d136
ToppCellfacs-Kidney-nan-3m-Mesenchymal|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAMTS12 CACNA1C BMP3 SRPX GDF10 SVEP1

2.57e-07189626381058f55908f84375b54601d617389ef43ab855
ToppCellfacs-Kidney-nan-3m-Mesenchymal-mesangial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAMTS12 CACNA1C BMP3 SRPX GDF10 SVEP1

2.57e-07189626302b950a6ad578f8aeff7ea6fd15fe631225287d
ToppCellfacs-Heart-LV-3m-Mesenchymal-fibroblast_of_cardiac_tissue|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SSC5D ARSJ THSD7A KCP LAMA4 SVEP1

2.81e-07192626671d4e1eee5aba03c43dbc98f4b51ce42b3df5d5
ToppCellfacs-Heart-LV-3m-Mesenchymal-fibroblast_of_cardiac_tissue|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SSC5D ARSJ THSD7A KCP LAMA4 SVEP1

2.81e-07192626840a34c1b82d218be999ab5e1bcafd6370d7a4b1
ToppCell368C-Fibroblasts-Fibroblast-G-|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

TMEM171 IGFBP5 LAMA4 GDF10 ZYX SVEP1

2.99e-07194626d9eec28fa7b255c0ec023276dd955f1e276e7159
ToppCellPCW_07-8.5-Mesenchymal-Mesenchymal_fibroblastic|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

ADAMTS12 CACNA1C IGFBP5 LAMA4 GDF10 SVEP1

2.99e-071946268c37bedb23285735ff3828db3889897fada8c95d
ToppCell368C-Fibroblasts-Fibroblast-G|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

TMEM171 IGFBP5 LAMA4 GDF10 ZYX SVEP1

2.99e-07194626e4d7e9709ce42d4610e44d3445927eefbcbb9eff
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature1_(0)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

ADAMTS12 CACNA1C THSD7A ASXL3 GDF10 SVEP1

3.27e-071976260034bae02ee7fcfea520d453ca3c842ab6963b12
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_immature1_(0)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

ADAMTS12 CACNA1C THSD7A ASXL3 GDF10 SVEP1

3.27e-0719762611a4c417f035e554431a8f03be13b5eefa3530c0
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_fibroblastic|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

ADAMTS12 CACNA1C THSD7A LAMA4 GDF10 SVEP1

3.37e-0719862617dc055e2a289496d9c5cdbf3297bdf906dc6d22
ToppCellControl-Stromal|Control / Disease state, Lineage and Cell class

CACNA1C PXDN IGFBP5 LAMA4 SRPX SVEP1

3.37e-07198626ae726b6b7f0a4107899be4d32ac256ffa0bd8d59
ToppCellCOVID-19-kidney-Fibroblast-2|kidney / Disease (COVID-19 only), tissue and cell type

ADAMTS12 CACNA1C PXDN LAMA4 NR4A3 SVEP1

3.37e-07198626ca26ca460856b1faaa3e83766da6abdf63af2b51
ToppCellControl_saline-Mesenchymal_fibroblastic-Fibroblasts-Diff_MatrixFB|Control_saline / Treatment groups by lineage, cell group, cell type

ADAMTS12 LAMA4 SRPX GDF10 ZYX SVEP1

3.47e-07199626c2c42ecf20d1924edc2f899c01dfa5fcf3c210b9
ToppCell10x3'2.3-week_17-19-Mesenchymal_fibro-stroma-arteriolar_fibroblast|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

ADAMTS12 ARSJ IGFBP5 LAMA4 SRPX SVEP1

3.47e-0719962695d95e9b7bd3933188998ae94986213eb0f1e5ea
ToppCellLPS_IL1RA_TNF-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

ADAMTS12 LAMA4 SRPX GDF10 ZYX SVEP1

3.47e-0719962630d3e8c0681ec11f86dd38c5f48d21187a1b4f90
ToppCellCOVID-19-kidney-Fibroblast-1|kidney / Disease (COVID-19 only), tissue and cell type

ADAMTS12 CACNA1C PXDN LAMA4 NR4A3 SVEP1

3.47e-071996269503646ff1ad248181146ce767e9d12e882ec3bd
ToppCell10x3'2.3-week_17-19-Mesenchymal_fibro-stroma|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

ADAMTS12 SSC5D ARSJ IGFBP5 LAMA4 SRPX

3.58e-07200626747c61d4e0b746278ae1f45ca4cd556c6961c76a
ToppCellLPS_only-Mesenchymal_fibroblastic-Fibroblasts-Diff_MatrixFB|LPS_only / Treatment groups by lineage, cell group, cell type

ADAMTS12 LAMA4 SRPX GDF10 ZYX SVEP1

3.58e-07200626ab4fda0cc95cb8f80ea9f28745013f3248def820
ToppCellControl_saline-Mesenchymal_fibroblastic|Control_saline / Treatment groups by lineage, cell group, cell type

ADAMTS12 LAMA4 SRPX GDF10 ZYX SVEP1

3.58e-0720062664ae5cf6cb4fc94cf1052abd82648f6b8e6445fe
ToppCellLPS_anti-TNF-Mesenchymal_fibroblastic-Fibroblasts|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

ADAMTS12 LAMA4 SRPX GDF10 ZYX SVEP1

3.58e-07200626b79628fd1386aa9a3b0e9fa81def0bc100c3c073
ToppCellLPS_anti-TNF-Mesenchymal_fibroblastic|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

ADAMTS12 LAMA4 SRPX GDF10 ZYX SVEP1

3.58e-0720062650ca6550998e461ef26dd670351060bd940765a8
ToppCellLPS_anti-TNF-Mesenchymal_fibroblastic-Fibroblasts-Diff_MatrixFB|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

ADAMTS12 LAMA4 SRPX GDF10 ZYX SVEP1

3.58e-072006263bdba9612cd7c612b76aa9abecc4a6529aabfc1c
ToppCelltumor_Lymph_Node_/_Brain-Fibroblasts|tumor_Lymph_Node_/_Brain / Location, Cell class and cell subclass

ADAMTS12 CACNA1C IGFBP5 LAMA4 SRPX GDF10

3.58e-072006264f7e26b27bd51c32420ed8c2f52d070aee542159
ToppCell10x3'2.3-week_17-19-Mesenchymal_fibro|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

ADAMTS12 SSC5D ARSJ IGFBP5 LAMA4 SRPX

3.58e-07200626de1d193f773f4e2927baa6fc38d29754b015c6e6
ToppCellLPS_IL1RA_TNF-Mesenchymal_fibroblastic-Fibroblasts|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

ADAMTS12 LAMA4 SRPX GDF10 ZYX SVEP1

3.58e-0720062644a68bacdb3d5bf563bd35952176995850933a81
ToppCellControl_saline-Mesenchymal_fibroblastic-Fibroblasts|Control_saline / Treatment groups by lineage, cell group, cell type

ADAMTS12 LAMA4 SRPX GDF10 ZYX SVEP1

3.58e-07200626a1fc74c1b27e104895910bc7cdce7ba33d30df7e
ToppCellLPS_IL1RA_TNF-Mesenchymal_fibroblastic|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

ADAMTS12 LAMA4 SRPX GDF10 ZYX SVEP1

3.58e-07200626dc61016c61729f69649cfb21f6264e685ce83dea
ToppCellControl_saline-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB|Control_saline / Treatment groups by lineage, cell group, cell type

ADAMTS12 LAMA4 SRPX GDF10 ZYX SVEP1

3.58e-07200626bd8cf33502adea320e91ca2af14e1911d88ad374
ToppCellAdult-Mesenchymal-chondrocyte-D231|Adult / Lineage, Cell type, age group and donor

ADAMTS12 CACNA1C LAMA4 SEZ6L2 SVEP1

3.31e-061646252ba57dce5f69a88f0d1e450b9780425e2d9ca7d4
ToppCell-Donor_05|World / lung cells shred on cell class, cell subclass, sample id

CACNA1C IGFBP5 LAMA4 GDF10 SVEP1

3.84e-061696258ebe9a88111c53a09c25a7b6a164a0a17880458d
ToppCellPND07-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC-VEC_G2M|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

METTL13 VWF ARSJ BAHD1 MASP2

4.42e-061746256c36d607c48267a75ab4da6fb2fe3f931d1b3b52
ToppCellprimary_visual_cortex-Neuronal-glutamatergic_neuron-L6_IT-L6_IT_VISp_Penk_Fst|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

BMP3 ARSJ PTPRK NR4A3 ADAMTS13

4.67e-06176625a1b9f8f199a028b3fa85de43fe96bc29f387bfd8
ToppCell3'-Child09-12-SmallIntestine-Mesenchymal-fibroblastic-Stromal_4_(MMP1+)|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ARSJ PXDN IGFBP5 LAMA4 ADAMTS13

4.81e-06177625ac90e4ce5be304a5a7473736397327010f2d1999
ToppCellTCGA-Colorectal-Primary_Tumor-Colorectal_Adenocarcinoma-Mucinous_Colon_Adenocarcinoma-10|TCGA-Colorectal / Sample_Type by Project: Shred V9

PXDN THSD7A DOCK8 LAMA4 SVEP1

5.08e-06179625cc079ba015326dccde955c5eafa3e4a2e40de192
ToppCelltumor_Lung-Fibroblasts-Undetermined|tumor_Lung / Location, Cell class and cell subclass

IGFBP5 LAMA4 SRPX GDF10 SVEP1

5.36e-0618162553bcab4d6df4a3255d81877ba22fb95d4492ce9f
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-3_VIP_ZNF322P1|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PXDN THSD7A IGFBP5 GDF10 SVEP1

5.50e-06182625d3a037268f026eb2f84428b1821022503cef7756
ToppCellCOVID-19-Heart-Fib_+_EC_+_Pericyte|COVID-19 / Disease (COVID-19 only), tissue and cell type

CACNA1C VWF PXDN SRPX SVEP1

5.50e-06182625fbd5e332df73bf7141c822fa67b76367dc962017
ToppCellCOVID-19-Heart-EC_3|COVID-19 / Disease (COVID-19 only), tissue and cell type

CACNA1C VWF THSD7A IGFBP5 ADAM15

5.65e-06183625ff95382cfed592190d0636d2b750328471f82e0d
ToppCelldroplet-Lung-3m-Epithelial-airway_epithelial-neuroendocrine_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

TMEM171 COL9A2 TMEM130 R3HDML SEZ6L2

5.80e-06184625e0e5a553fb8c0947679634396d20c2ca8455b932
ToppCelldroplet-Kidney-nan-21m-Mesenchymal-fibroblast|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SSC5D LAMA4 SRPX GDF10 SVEP1

5.80e-061846253bffadb0cb2e0d825bdb6cfc5d23f5436cbc3efd
ToppCelldroplet-Lung-3m-Epithelial-airway_epithelial-neuroendocrine_cell-neuroendocrine|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

TMEM171 COL9A2 TMEM130 R3HDML SEZ6L2

5.80e-06184625c3b848e1438a84b3fac8a4e40f3db478cc84d970
ToppCelldroplet-Kidney-nan-21m-Mesenchymal|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SSC5D LAMA4 SRPX GDF10 SVEP1

5.96e-0618562533cc0e9d8b54cb7408b51235f2a70e044ebae04d
ToppCelldroplet-Lung-immune-endo-depleted-3m-Epithelial-lung_neuroendocrine_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TMEM171 COL9A2 TMEM130 R3HDML SEZ6L2

5.96e-0618562530263c558ee331e0879abcf8b4c2427ff05f9fe7
ToppCellAdult-Mesenchymal-matrix_fibroblast_2_cell-D231|Adult / Lineage, Cell type, age group and donor

CACNA1C SSC5D IGFBP5 LAMA4 SVEP1

5.96e-06185625fb6bd7e849ecf4ed9cd9c4e2a946a2d12d62f804
ToppCelldroplet-Kidney-nan-21m-Mesenchymal-Stroma____fibroblast|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SSC5D LAMA4 SRPX GDF10 SVEP1

5.96e-061856259954fc85b183c1cc45c3c24e3dadc7984ee6f649
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-3_VIP_ZNF322P1|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PXDN THSD7A IGFBP5 GDF10 SVEP1

5.96e-061856250b5a0df58ae2ad8261f40f152775747af4f3937a
ToppCelldroplet-Lung-immune-endo-depleted-3m-Epithelial-Neuroendocrine|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TMEM171 COL9A2 TMEM130 R3HDML SEZ6L2

5.96e-061856251b000ca11970db8f347eb97ff44605d562aea70a
ToppCell356C-Endothelial_cells-Endothelial-E-|356C / Donor, Lineage, Cell class and subclass (all cells)

VWF PXDN LAMA4 SRPX TAF1L

6.12e-061866252e024097ee361eeb1d855a4edb8ac8cdad35da06
ToppCell356C-Endothelial_cells-Endothelial-E|356C / Donor, Lineage, Cell class and subclass (all cells)

VWF PXDN LAMA4 SRPX TAF1L

6.12e-06186625c3449e54454009973818fc1101933c6f0168258c
ToppCellAdult-Mesenchymal-matrix_fibroblast_1_cell-D175|Adult / Lineage, Cell type, age group and donor

ADAMTS12 CACNA1C ASXL3 LAMA4 SVEP1

6.28e-06187625e15d2967aac248da3517bc2c7d1beaa1d5a0aa7f
ToppCellControl-Fibroblasts-Other_FB|Control / group, cell type (main and fine annotations)

ADAMTS12 CACNA1C SSC5D LAMA4 SVEP1

6.28e-06187625bd3739c4a52aa1ba5deffd778e113a9800f7e158
ToppCelldroplet-Kidney-nan-3m-Mesenchymal-fibroblast|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAMTS12 SSC5D SRPX GDF10 SVEP1

6.78e-06190625f61e21d53f2f7804ac6e40ab6c7f69838aa94d6a
ToppCelldroplet-Kidney-nan-3m-Mesenchymal|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAMTS12 SSC5D SRPX GDF10 SVEP1

6.78e-061906252abeb013bb83c578e67dcb985ba44ca63134950b
ToppCellLPS-IL1RA+antiTNF-Stromal_mesenchymal-Matrix_Fibroblast-Activated_MatrixFB|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ADAMTS12 CACNA1C LAMA4 GDF10 SVEP1

6.96e-06191625b13229bb7f3713a392271aaf5dbae3edd1b9fe5a
ToppCellfacs-Heart-LV-3m-Mesenchymal|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SSC5D THSD7A KCP LAMA4 SVEP1

6.96e-06191625b7a57691a4742070cee640e285c1f4d0da95baf1
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ADAMTS12 SSC5D IGFBP5 NR4A3 SVEP1

6.96e-061916251caf726bd07fdca389e678fc16304a6ef1790423
ToppCelldroplet-Lung-1m-Mesenchymal-fibroblast|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

BMP3 LAMA4 SRPX GDF10 SVEP1

6.96e-06191625ce80f65bd24b1c4d2152bf45248449e7a1a97e56
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-3_VIP_GGH|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PXDN THSD7A IGFBP5 SEZ6L2 SVEP1

6.96e-0619162506760c3bb40e4f66879a5f5e09c9abfce4ebbba3
ToppCellASK454-Mesenchymal|ASK454 / Donor, Lineage and Cell class of Lung cells from Dropseq

SSC5D TMEM130 IGFBP5 LAMA4 SVEP1

6.96e-06191625e30ae7a12439f8a79820b13f03e822c1223fd0cb
ToppCellPCW_07-8.5-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_COL13A1^pos_fibro1_(4)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

ADAMTS12 CACNA1C IGFBP5 LAMA4 GDF10

6.96e-06191625fa380a8752de158974b2ae5e741573439719cc0d
ToppCellASK454-Mesenchymal-Fibroblast|ASK454 / Donor, Lineage and Cell class of Lung cells from Dropseq

SSC5D TMEM130 IGFBP5 LAMA4 SVEP1

6.96e-061916251726add3f392a061536b7aff72ba84303f4a0b1f
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ADAMTS12 SSC5D IGFBP5 NR4A3 SVEP1

6.96e-061916253d60c46bced2984c27a1fcf2910bc38b31fb0148
ToppCelldroplet-Kidney-nan-3m-Mesenchymal-Stroma____fibroblast|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAMTS12 SSC5D SRPX GDF10 SVEP1

6.96e-06191625d1205aab0937f2becfcd239610e9b78fb8a0c886
ToppCellCOVID-19-Heart-Fib_+_EC_+_Pericyte|Heart / Disease (COVID-19 only), tissue and cell type

VWF ARSJ PXDN SRPX SVEP1

7.14e-0619262560b1312e84f6d6448365a952469c506c00b5fe93
ToppCellLPS-IL1RA+antiTNF-Stromal_mesenchymal|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ADAMTS12 CACNA1C LAMA4 GDF10 SVEP1

7.14e-061926253d0cb19f037f604253d7d728689aeaa94251e92b
ToppCellCOPD-Stromal-Myofibroblast|Stromal / Disease state, Lineage and Cell class

ADAMTS12 LAMA4 GDF10 ZYX SVEP1

7.14e-0619262562904f94dfce430456f05066522cbf9bd29f4d7e
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_COL13A1^pos_fibro1_(4)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

ADAMTS12 CACNA1C PTPRK LAMA4 ZYX

7.32e-061936259f69edc97b868d23998abc98928a2e89a885ef8a
ToppCellPCW_07-8.5-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_adventitial_fibro_(9)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

ADAMTS12 THSD7A LAMA4 GDF10 SVEP1

7.50e-061946255f5f0cdeacd5e1b28717d78dabdb9eb95f661e36
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ADAMTS12 PXDN IGFBP5 LAMA4 SVEP1

7.50e-06194625240d122dcb9dd1ab2867503ad85869853adcacae
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ADAMTS12 PXDN IGFBP5 LAMA4 SVEP1

7.50e-06194625ae7df037592f1c20c9d32be15fe6fc3c562ebeb1
ToppCellControl-Stromal-Myofibroblast|World / Disease state, Lineage and Cell class

ADAMTS12 CACNA1C LAMA4 GDF10 SVEP1

7.50e-061946253c2266772c5b56e8e02a461e5193e29588028ee9
ToppCellLPS-antiTNF-Stromal_mesenchymal|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ADAMTS12 CACNA1C LAMA4 GDF10 SVEP1

7.50e-061946256e13549f697f7478b34fe71f7dd9d63c5d3db22e
ToppCellLPS-antiTNF-Stromal_mesenchymal-Matrix_Fibroblast-Activated_MatrixFB|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ADAMTS12 CACNA1C ASXL3 LAMA4 SVEP1

7.50e-0619462589b706af2b25991fc2707eb24f49ba6ff3ae01f7
ToppCellTCGA-Blood_and_Bone_Marrow-Primary_Tumor-Diffuse_large_B-cell_lymphoma-DLBCL-1|TCGA-Blood_and_Bone_Marrow / Sample_Type by Project: Shred V9

ADAMTS12 TRAFD1 ARSJ PTPRK LAMA4

7.50e-06194625eaeeb84576270cc3fc59002ba33bff9639bb0b02
ToppCellPCW_07-8.5-Mesenchymal-Mesenchymal_fibroblastic-mes_immature1_(0)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

ADAMTS12 THSD7A LAMA4 GDF10 SVEP1

7.50e-06194625a3e5a15cf6c1361207f661ee15eb634f77daf1cb
ToppCellControl-Stromal-Myofibroblast|Control / Disease state, Lineage and Cell class

ADAMTS12 CACNA1C LAMA4 GDF10 SVEP1

7.69e-06195625ffcf76cd72e43d8cf1058a49c76e0956065038bc
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_immature3_(17)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

ADAMTS12 THSD7A LAMA4 GDF10 SVEP1

7.69e-061956251cdf5f296029ae424d9dba42e86a6d111e4896e6
ToppCellControl-Stromal-Fibroblast|Control / Disease state, Lineage and Cell class

PXDN IGFBP5 LAMA4 SRPX SVEP1

7.89e-061966257ca94477498a84cafcdd9933ee92a6cbde76c70e
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_fibroblastic|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

ADAMTS12 THSD7A LAMA4 GDF10 SVEP1

7.89e-061966251450cb69c5bf469e97c03bf1890f6f7c54165b8a
ToppCellTracheal-NucSeq-Stromal-Fibroblastic-Fibro_myofibroblast|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

CACNA1C LAMA4 SRPX GDF10 SVEP1

8.08e-061976250dd71e399f253787fa546a7e90c5373180b89ffd
ToppCellCOPD-Stromal-Myofibroblast|World / Disease state, Lineage and Cell class

ADAMTS12 CACNA1C LAMA4 GDF10 SVEP1

8.08e-06197625d51f484b4e01ac64233950d0b97fa88825ea1dbb
ToppCell10x_3'_v3-tissue-resident_(10x_3'_v3)-mesenchymal-mesenchymal-mesenchymal_stem_cell|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

PXDN IGFBP5 LAMA4 SRPX SVEP1

8.08e-061976253bb92dd8a94e2be3b7fe51c9a21b241215477ac7
ToppCellPCW_13-14-Mesenchymal|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

ADAMTS12 CACNA1C LAMA4 GDF10 SVEP1

8.08e-0619762573a2085d2682d636726a5432d572ae2a3fbe1c3f
ToppCell10x_3'_v3-tissue-resident_(10x_3'_v3)-mesenchymal|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

PXDN IGFBP5 LAMA4 SRPX SVEP1

8.08e-0619762517344464fdcc5ba0c03959696b97c195f11e644c
ToppCellCOPD-Stromal|COPD / Disease state, Lineage and Cell class

CACNA1C IGFBP5 LAMA4 GDF10 SVEP1

8.08e-06197625d5390d86acaa8c39f1da893e8d2271f9ed2951d7
ToppCell10x_3'_v3-tissue-resident_(10x_3'_v3)-mesenchymal-mesenchymal|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

PXDN IGFBP5 LAMA4 SRPX SVEP1

8.08e-061976255b8d0d7116b20d8e27541e88ec80c9f1f477e384
ToppCellLPS_IL1RA_TNF-Mesenchymal_fibroblastic-Fibroblasts-Diff_MatrixFB|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

ADAMTS12 SRPX GDF10 ZYX SVEP1

8.28e-061986250a4b19c3d5e65ecd24fc2ce80ac5276c813282c7
ToppCellbackground-Hepatic_Stellate_cells|World / Sample and Cell Type and Tumor Cluster (all cells)

SSC5D IGFBP5 ADAMTS13 SRPX SVEP1

8.28e-0619862579f32f965aed6a10c5cb803173e3db7b32e07a91
ToppCell(5)_Fibroblasts-(5)_Fibroblast-B_(Myofibroblast)|(5)_Fibroblasts / Lung cell shreds - cell class (v4) and cell subclass (v4)

ADAMTS12 SSC5D IGFBP5 SPRR3 SEZ6L2

8.28e-06198625196257c4420ac801ed9fbb444f11718adb7560ae
ToppCellbackground-Hepatic_Stellate_cells|background / Sample and Cell Type and Tumor Cluster (all cells)

CACNA1C SSC5D IGFBP5 ADAMTS13 SVEP1

8.28e-06198625bd11b0e9e80449aab979a02c1023e0638c431c7c
ToppCell5'-Parenchyma_lung-Endothelial-Blood_vessel_EC-capillary_endothelial_cell-EC_general_capillary-EC_general_capillary_L.2.0.2.2|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

VWF PXDN ADAM15 LAMA4 SRPX

8.28e-061986250c8ec287500c58938ecc0dbbbc5f6c7a48733fc6
ToppCellcellseq-Mesenchymal-Fibroblastic-Fibroblastic_2-AF1|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

ADAMTS12 CACNA1C LAMA4 GDF10 SVEP1

8.28e-06198625f1374f7a50244d59c766ac41f44c08c9117407d2
ToppCellproximal-mesenchymal-Alveolar_Fibroblast|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

ADAMTS12 LAMA4 GDF10 ZYX SVEP1

8.49e-061996257f4840ae6a888380feca722543e5e52783f3e35d
ToppCellFetal_29-31_weeks|World / Lineage, Cell type, age group and donor

ADAMTS12 CACNA1C PXDN ASXL3 LAMA4

8.49e-061996255b9d355795dd03a22f0961dfd143425c367a4654
ToppCellproximal-3-mesenchymal-Alveolar_Fibroblast|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

ADAMTS12 LAMA4 GDF10 ZYX SVEP1

8.49e-06199625301d02bbb37e6f1d24b6e865bc3fe3e91260eb30
ToppCell3'-GW_trimst-1-SmallIntestine-Mesenchymal|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PXDN IGFBP5 LAMA4 ZYX SVEP1

8.49e-0619962536c1deac7ef0f9ebde6b2f7a63f7daa03d8c139a
DrugUAMC00132

DPP9 DPP8

7.30e-062622ctd:C524159
DrugMephenytoin [50-12-4]; Up 200; 18.4uM; HL60; HT_HG-U133A

ADAMTS12 MYT1 CACNA1I TACC2 MUC2 SH3D21

1.55e-051966266158_UP
DrugDeltaline [6836-11-9]; Up 200; 7.8uM; HL60; HT_HG-U133A

TRAFD1 THSD7A SRPX SH3D21 SVEP1 MASP2

1.64e-051986262171_UP
DrugDizocilpine maleate [77086-22-7]; Up 200; 11.8uM; MCF7; HT_HG-U133A

ADAMTS12 IGFBP5 TAF1 MUC5AC SH3D21 SVEP1

1.69e-051996262232_UP
DrugSureCN3749646

DPP9 DPP8

2.18e-053622CID011530920
DrugMfpa

TAF1 TAF1L

2.18e-053622CID003035615
DrugSureCN3745540

DPP9 DPP8

2.18e-053622CID011974437
DrugSureCN3749947

DPP9 DPP8

2.18e-053622CID011974435
DrugABT-279

DPP9 DPP8

2.18e-053622CID016049769
DrugCyanopyrrolidine 38

DPP9 DPP8

2.18e-053622CID010932707
DrugCyanopyrrolidine 39

DPP9 DPP8

2.18e-053622CID011117606
DrugSureCN3748611

DPP9 DPP8

2.18e-053622CID011974325
DrugDiprolyl-alanine

DPP9 DPP8

2.18e-053622CID000193559
Drugglycylproline 4-nitroanilide

DPP9 DPP8

4.36e-054622ctd:C042892
Drugcypermethrin

SP100 DPP9 DPP8

6.00e-0528623CID000002912
DrugDeprolorphin

PTPN11 DPP9 DPP8

6.00e-0528623CID000122318
Drugprodipine

DPP9 DPP8

7.26e-055622CID000065775
Drugarginyl(PMC)-pyrrolidine-2-nitrile

DPP9 DPP8

7.26e-055622CID000487437
Drugalanylproline-4-nitroanilide

DPP9 DPP8

7.26e-055622ctd:C083013
DrugProtease Inhibitors

DPP9 DPP8

1.09e-046622ctd:D011480
Drugcathepsin C substrate

DPP9 DPP8

1.09e-046622CID003508173
DrugNVP-DPP728

DPP9 DPP8

1.09e-046622CID009796290
DrugIn2-7

COL9A2 VWF

1.09e-046622CID002816385
DrugMK-251

DPP9 DPP8

1.09e-046622CID000176160
DrugII 19

DPP9 DPP8

1.09e-046622CID000040321
DrugMifepristone

VWF PXDN IGFBP5 PTPRK ADAM15 HRAS SRPX SVEP1

1.23e-04553628ctd:D015735
DrugEpostatin

DPP9 DPP8

1.52e-047622CID006449105
Drugo-Py

DPP9 DPP8

1.52e-047622CID009942336
DrugPF-00875133-00 [351322-64-0]; Up 200; 10uM; MCF7; HT_HG-U133A

ADAMTS12 IGFBP5 TAF1 TNFRSF21 SH3D21

1.77e-041926255967_UP
DrugPromethazine hydrochloride [58-33-3]; Up 200; 12.4uM; HL60; HT_HG-U133A

THSD7A CACNA1I ADAMTS13 SH3D21 CASZ1

1.86e-041946253100_UP
DrugFolic acid [59-30-3]; Up 200; 9uM; MCF7; HT_HG-U133A

ADAMTS12 TRAFD1 CACNA1I TAF1 TNFRSF21

1.95e-041966252783_UP
DrugPHA-00745360 [351320-33-7]; Down 200; 10uM; MCF7; HT_HG-U133A

IGFBP5 CACNA1I SRPX SVEP1 MASP2

1.95e-041966254381_DN
DrugAmpyrone [83-07-8]; Up 200; 19.6uM; MCF7; HT_HG-U133A

ADAMTS12 MYT1 LAMA4 TNFRSF21 SVEP1

2.00e-041976252249_UP
DrugCID6451162

DPP9 DPP8

2.02e-048622CID006451162
Drug4-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-anthracenyl)benzoic acid

MUC2 MUC5AC

2.02e-048622ctd:C064545
DrugP32/98

DPP9 DPP8

2.02e-048622CID006918464
Drugimidazolelactate

DPP9 DPP8

2.02e-048622CID000000793
Drugnovobiocin sodium, USP; Up 200; 100uM; MCF7; HG-U133A

TRAFD1 SAC3D1 CACNA1I TNFRSF21 MASP2

2.05e-04198625437_UP
Drug(S)-(-)-Atenolol [93379-54-5]; Up 200; 15uM; HL60; HT_HG-U133A

PTPRK NR4A3 CACNA1I ADAMTS13 CASZ1

2.05e-041986253067_UP
DrugTetramisole hydrochloride [16595-80-5]; Up 200; 16.6uM; MCF7; HT_HG-U133A

SP100 LAMA4 TAF1 MUC2 SVEP1

2.05e-041986252849_UP
DrugAvermectin B1 [71751-41-2]; Up 200; 4.8uM; HL60; HT_HG-U133A

IGFBP5 LAMA4 CACNA1I MUC2 TNFRSF21

2.05e-041986252519_UP
DrugLobeline alpha (-) hydrochoride [134-63-4]; Up 200; 10.6uM; MCF7; HT_HG-U133A

IGFBP5 ADAMTS13 MUC5AC SH3D21 MASP2

2.10e-041996252763_UP
DrugLeucomisine [17946-87-1]; Up 200; 16.2uM; MCF7; HT_HG-U133A

SP100 IGFBP5 LAMA4 CACNA1I MUC5AC

2.10e-041996253546_UP
DrugPargyline hydrochloride [306-07-0]; Up 200; 20.4uM; MCF7; HT_HG-U133A

SP100 IGFBP5 ADAMTS13 SRPX TNFRSF21

2.10e-041996257016_UP
DrugCitalopram hydrobromide [59729-32-7]; Down 200; 1uM; PC3; HT_HG-U133A

SP100 COL9A2 IGFBP5 BAHD1 CASZ1

2.10e-041996254555_DN
DrugICI182,780; Down 200; 1uM; PC3; HT_HG-U133A

SP100 ADAM15 CACNA1I TAF1 MASP2

2.14e-042006255931_DN
DrugCinnarizine

CACNA1C CACNA1I

2.59e-049622DB00568
DrugNSC-334212

DPP9 DPP8

2.59e-049622CID000333414
DrugGly-pro-na

DPP9 DPP8

2.59e-049622CID000194319
Drugisoindoline

DPP9 DPP8

2.59e-049622CID000422477
DrugAppna

DPP9 DPP8

2.59e-049622CID006453929
DrugPhe-pro-ala

DPP9 DPP8

2.59e-049622CID000133668
DrugSureCN475872

DPP9 DPP8

2.59e-049622CID011163584
Diseaseextrapulmonary tuberculosis

CACNA1C THSD7A ADAM15

1.92e-0612623MONDO_0000368
Diseasecystitis (is_marker_for)

MUC2 MUC5AC

4.34e-062622DOID:1679 (is_marker_for)
Diseasesputum mucin-5B amount

MUC2 MUC5AC

1.30e-053622OBA_2050332
DiseaseSushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 measurement

ADAM15 SVEP1

2.60e-054622EFO_0803113
Diseasemucinous adenocarcinoma (is_marker_for)

MUC2 MUC5AC

4.33e-055622DOID:3030 (is_marker_for)
DiseaseNeuroblastoma

PTPN11 DOCK8 HRAS

1.34e-0447623C0027819
Diseasebringing up phlegm, sputum or mucus on most days, self-reported

MUC2 MUC5AC

1.55e-049622EFO_0009824
Diseasecystatin C measurement

GRAMD2A PTPN11 TRAFD1 KCP ATF6B MASP2

1.99e-04402626EFO_0004617
Diseasevon Willebrand factor measurement

TMEM171 VWF ADAMTS13

2.26e-0456623EFO_0004629
DiseaseTurner Syndrome, Male

PTPN11 HRAS

2.36e-0411622C0041409
DiseaseFemale Pseudo-Turner Syndrome

PTPN11 HRAS

2.36e-0411622C1527404
DiseaseNoonan Syndrome 1

PTPN11 HRAS

2.36e-0411622C4551602
Diseaseeosinophil count

PTPN11 TRAFD1 PXDN MYT1 HRAS KCP MUC2 MUC5AC ATF6B SF3B5 SVEP1

2.45e-0414886211EFO_0004842
Diseasesystemic lupus erythematosus

TRAFD1 RAPH1 ADAM15 MYT1 KCP NR4A3 IQCN SEZ6L2

2.59e-04799628MONDO_0007915
Diseaseage-related macular degeneration, COVID-19

DPP9 TACC2 CFHR4

4.19e-0469623EFO_0001365, MONDO_0100096
DiseaseRASopathy

PTPN11 HRAS

4.48e-0415622cv:C5555857
DiseaseT-Cell Lymphoma

ASXL3 HRAS

5.11e-0416622C0079772
Diseaseidiopathic scoliosis (implicated_via_orthology)

PTPN11 SSPOP

5.11e-0416622DOID:0060250 (implicated_via_orthology)
Diseasealcohol dependence

CACNA1C ASXL3 MUC2 MUC5AC

6.03e-04183624MONDO_0007079
DiseaseAgents acting on the renin-angiotensin system use measurement

CACNA1C PTPN11 MYT1 CASZ1 SVEP1

6.97e-04335625EFO_0009931
DiseaseNoonan-Like Syndrome With Loose Anagen Hair

PTPN11 HRAS

7.26e-0419622C3501846
DiseaseCostello syndrome (disorder)

PTPN11 HRAS

7.26e-0419622C0587248
DiseaseNoonan syndrome-like disorder with loose anagen hair

PTPN11 HRAS

7.26e-0419622C1843181
Diseasefactor VIII measurement, Ischemic stroke

TMEM171 VWF

7.26e-0419622EFO_0004630, HP_0002140
Diseaseleukemia (implicated_via_orthology)

PTPN11 HRAS

7.26e-0419622DOID:1240 (implicated_via_orthology)
DiseaseCardio-facio-cutaneous syndrome

PTPN11 HRAS

7.26e-0419622C1275081
DiseaseVaricose veins

DOCK8 ADAM15 SRPX CASZ1

7.36e-04193624HP_0002619
Diseasesystemic scleroderma

PXDN KCP CR2

7.72e-0485623EFO_0000717
Diseaseglaucoma (is_marker_for)

PTPN11 MUC5AC

8.05e-0420622DOID:1686 (is_marker_for)
Diseasecoagulation factor measurement

VWF CFHR4

8.05e-0420622EFO_0004634
DiseaseLEOPARD Syndrome

PTPN11 HRAS

9.77e-0422622C0175704
DiseaseNeurodevelopmental Disorders

PTPN11 DOCK8 ASXL3

1.00e-0393623C1535926
DiseaseNoonan Syndrome

PTPN11 HRAS

1.16e-0324622C0028326
Diseasefactor VIII measurement, von Willebrand factor measurement

TMEM171 VWF

1.47e-0327622EFO_0004629, EFO_0004630
DiseaseIschemic stroke, von Willebrand factor measurement

TMEM171 VWF

1.82e-0330622EFO_0004629, HP_0002140
Diseasevon Willebrand factor measurement, coronary artery disease

TMEM171 VWF TRAFD1

1.99e-03118623EFO_0001645, EFO_0004629
Diseasecoffee consumption

PTPN11 TRAFD1

2.07e-0332622EFO_0004330

Protein segments in the cluster

PeptideGeneStartEntry
GIPEPCCVPEKMSSL

BMP3

431

P12645
MEPASCCAERPKPGP

BRICD5

1

Q6PL45
CTDPPAGKPAMAPKR

CASZ1

11

Q86V15
PCPGPAPAKTCIMEA

ADAM15

366

Q13444
PASPEPGFCATLCPM

ASXL3

411

Q9C0F0
PGFCATLCPMVEIPP

ASXL3

416

Q9C0F0
IPPPLSMSCNPEPCE

ADAMTS12

1411

P58397
EKLPAPEPCVGMSCP

ADAMTS13

851

Q76LX8
LNPPDESGPGCMSCK

HRAS

171

P01112
PGSAMAQLKPAPCAP

RAPH1

721

Q70E73
PCPAACEVQGMLVPP

IQCN

821

Q9H0B3
EKMQPCCKAPDIPTP

KIAA0100

626

Q14667
TALPCPPCQVPIPME

NFXL1

626

Q6ZNB6
PPPSPQACVCPGKML

ARSJ

11

Q5FYB0
PGIPEPCCVPDKMNS

GDF10

436

P55107
VECEPPPMPTCSNGL

MUC2

4446

Q02817
DEKALSMCPPSPLGC

IGFBP5

31

P24593
SMCPPSPLGCELVKE

IGFBP5

36

P24593
KMQCVATCPTPPLPP

MUC5AC

1221

P98088
PPCTPTPPCAEMRED

PTPN11

561

Q06124
LACMPGKKCAPESEP

CACNA1C

1471

Q13936
TKMPVCEEIFCPSPP

CR2

266

P20023
CCLTPEMLPVKPFPE

DOCK8

521

Q8NF50
PICLGTAPGCLMPAV

ERVK-24

51

P61566
GPRMDPKICPADPAF

DPP9

186

Q86TI2
DSSGDPKLCPIPMTP

CACNA1I

896

Q9P0X4
CPNIRMDPKLCPADP

DPP8

211

Q6V1X1
DFLCPTNCPPGMKGP

COL9A2

171

Q14055
CPMLPEGKLSPVAAP

BAHD1

396

Q8TBE0
EPPRCISMKPCEFPE

CFHR4

261

Q92496
RPMPACSIVDCGPPD

MASP2

356

O00187
VDSKDPTLGMSCPPP

METTL13

576

Q8N6R0
GPACPKKMPNCSPTA

GRAMD2A

271

Q8IUY3
ELPVGTCPDMCPAAE

SAC3D1

51

A6NKF1
ESPYKMGKPCSSCPP

R3HDML

216

Q9H3Y0
PGPPLITRTKCAEPM

PTPRK

376

Q15262
EPPTGMDCPTISCDK

LAMA4

261

Q16363
CIAPGPLLDPPMKAV

NR4A3

166

Q92570
PPQPPSSERCLGEMK

SH3D21

421

A4FU49
QPCAGPVPGMCPRDK

SSPOP

3081

A2VEC9
QPCPWPMIEKLPCAA

TNFRSF21

111

O75509
IGMCPTCKEPFPKSD

TRAFD1

36

O14545
MPLGSRVCKLPCPED

THSD7A

1151

Q9UPZ6
PSLMDQSKPCPVKPC

THSD7A

1326

Q9UPZ6
DCEDIDCKLMPPPPP

TAF1L

146

Q8IZX4
ADCEDIDCKLMPPPP

TAF1

146

P21675
VRCMALKCPPSPCPE

KCP

226

Q6ZWJ8
QCCNPPLSEEMLPPG

PHF12

81

Q96QT6
PPACQKIMTCADPGE

SEZ6L2

696

Q6UXD5
PASCVDMEPPRIKCP

SRPX

171

P78539
GPCVAPTPPVRVMAC

SSC5D

1471

A1L4H1
PMSIQCIPVRCGEPP

SVEP1

2136

Q4LDE5
PLMCVPLDCGKPPPI

SVEP1

2256

Q4LDE5
KMLQPCGPPADKPEE

SF3B5

71

Q9BWJ5
CTKVPEPGCTKVPEP

SPRR3

66

Q9UBC9
KVPEPGCTKVPEPGC

SPRR3

76

Q9UBC9
PMPGNSCPPEVDAKL

ATF6B

311

Q99941
CPMKPKKEASEVCPP

PIAS3

406

Q9Y6X2
KDLFEGRPPMEQPPC

TCEAL1

76

Q15170
PSEGCFCPPDKVMLE

VWF

2231

P04275
FCPPDKVMLEGSCVP

VWF

2236

P04275
GREMPCPLPCDEESP

SP100

261

P23497
KPLLPFATGPPTECM

PXDN

946

Q92626
MCGQKAPDLPPVPEE

TMEM52B

151

Q4KMG9
MPFAECPPEGCLASP

TACC2

111

O95359
SPVPLREPMKAPLCG

TACC2

201

O95359
PLPDCPMVLKVAGPA

TMEM171

51

Q8WVE6
CFAVPDPLMPDPSKQ

PRKRA

106

O75569
APRCSVCSEPIMPEP

ZYX

501

Q15942
PMSDKNPEPPSGVRC

TMEM130

381

Q8N3G9
EDPELMKCPVPGCVG

MYT1

886

Q01538