Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionvoltage-gated calcium channel activity involved in regulation of cytosolic calcium levels

CACNA1A CACNA1B

6.30e-059272GO:0099511
GeneOntologyMolecularFunctionvoltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels

CACNA1A CACNA1B

6.30e-059272GO:0099626
GeneOntologyMolecularFunctionhigh voltage-gated calcium channel activity

CACNA1A CACNA1B

1.59e-0414272GO:0008331
GeneOntologyMolecularFunctionvoltage-gated calcium channel activity

CACNA1A CACNA1B

1.76e-0346272GO:0005245
GeneOntologyMolecularFunctionpentosyltransferase activity

GXYLT1 TIPARP

2.59e-0356272GO:0016763
GeneOntologyMolecularFunctionATP hydrolysis activity

MDN1 DHX37 ATAD2B DDX10

2.75e-03441274GO:0016887
DomainGPHH_dom

CACNA1A CACNA1B

3.90e-057262IPR031649
DomainVDCC_a1su_IQ

CACNA1A CACNA1B

3.90e-057262IPR014873
DomainCa_chan_IQ

CACNA1A CACNA1B

3.90e-057262SM01062
DomainCa_chan_IQ

CACNA1A CACNA1B

3.90e-057262PF08763
DomainGPHH

CACNA1A CACNA1B

3.90e-057262PF16905
DomainVDCCAlpha1

CACNA1A CACNA1B

8.33e-0510262IPR002077
DomainP-loop_NTPase

MYO15B MDN1 HNRNPUL1 CHST7 DHX37 ATAD2B DDX10

1.20e-04848267IPR027417
Domain-

MDN1 HNRNPUL1 CHST7 DHX37 ATAD2B DDX10

4.62e-047462663.40.50.300
DomainChannel_four-helix_dom

CACNA1A CACNA1B

2.84e-0357262IPR027359
Domain-

CACNA1A CACNA1B

2.84e-03572621.20.120.350
DomainDEAD

DHX37 DDX10

4.61e-0373262PF00270
DomainDEAD/DEAH_box_helicase_dom

DHX37 DDX10

4.61e-0373262IPR011545
PathwayREACTOME_PRESYNAPTIC_DEPOLARIZATION_AND_CALCIUM_CHANNEL_OPENING

CACNA1A CACNA1B

3.03e-0511112M26913
PathwayKEGG_MEDICUS_REFERENCE_CA2_CAM_VGCC_RYR_SIGNALING_PATHWAY

CACNA1A CACNA1B

3.03e-0511112M47958
PathwayREACTOME_PRESYNAPTIC_DEPOLARIZATION_AND_CALCIUM_CHANNEL_OPENING

CACNA1A CACNA1B

3.03e-0511112MM14498
PathwayKEGG_MEDICUS_REFERENCE_VGCC_CA2_APOPTOTIC_PATHWAY

CACNA1A CACNA1B

1.39e-0423112M47666
PathwayKEGG_MEDICUS_REFERENCE_CA2_ENTRY_VOLTAGE_GATED_CA2_CHANNEL

CACNA1A CACNA1B

1.64e-0425112M47948
PathwayWP_METAPATHWAY_BIOTRANSFORMATION_PHASE_I_AND_II

CYP4V2 GLYATL1 CHST7

3.29e-04183113M39588
PathwayKEGG_TYPE_II_DIABETES_MELLITUS

CACNA1A CACNA1B

5.87e-0447112M19708
PathwayWP_SYNAPTIC_VESICLE_PATHWAY

CACNA1A CACNA1B

6.91e-0451112M39457
PathwayKEGG_TASTE_TRANSDUCTION

CACNA1A CACNA1B

7.19e-0452112M5785
PathwayWP_MAPK_SIGNALING

CACNA1A CACNA1B TAOK3

7.81e-04246113M39597
PathwayKEGG_MAPK_SIGNALING_PATHWAY

CACNA1A CACNA1B TAOK3

9.90e-04267113M10792
PathwayWP_DRAVET_SYNDROME_SCN1AA1783V_POINT_MUTATION_MODEL

CACNA1A CACNA1B

1.41e-0373112MM16641
PathwayREACTOME_RAC2_GTPASE_CYCLE

MCF2 TAOK3

2.00e-0387112MM15600
PathwayREACTOME_RAC2_GTPASE_CYCLE

MCF2 TAOK3

2.04e-0388112M41810
PathwayREACTOME_RAC3_GTPASE_CYCLE

MCF2 TAOK3

2.28e-0393112MM15609
PathwayREACTOME_RAC3_GTPASE_CYCLE

MCF2 TAOK3

2.33e-0394112M41818
PathwayWP_CALCIUM_REGULATION_IN_CARDIAC_CELLS

CACNA1A CACNA1B

5.58e-03147112MM15854
PathwayWP_CALCIUM_REGULATION_IN_CARDIAC_CELLS

CACNA1A CACNA1B

5.88e-03151112M39329
PathwayWP_METAPATHWAY_BIOTRANSFORMATION

CYP4V2 CHST7

6.04e-03153112MM15844
PathwayREACTOME_RAC1_GTPASE_CYCLE

MCF2 TAOK3

7.83e-03175112MM15599
PathwayKEGG_CALCIUM_SIGNALING_PATHWAY

CACNA1A CACNA1B

8.09e-03178112M2890
PathwayREACTOME_RAC1_GTPASE_CYCLE

MCF2 TAOK3

8.62e-03184112M41809
PathwayREACTOME_TRANSMISSION_ACROSS_CHEMICAL_SYNAPSES

CACNA1A CACNA1B

1.12e-02211112MM14502
PathwayREACTOME_BIOLOGICAL_OXIDATIONS

CYP4V2 GLYATL1

1.22e-02220112M10320
Pubmed

Stable respiratory activity requires both P/Q-type and N-type voltage-gated calcium channels.

CACNA1A CACNA1B

5.80e-07227223426690
Pubmed

Expression analysis of P/Q-type Ca2+ channel alpha 1A subunit mRNA in olfactory mitral cell in N-type Ca2+ channel alpha 1B subunit gene-deficient mice.

CACNA1A CACNA1B

5.80e-07227215050706
Pubmed

CaV 2.1 α1  subunit motifs that control presynaptic CaV 2.1 subtype abundance are distinct from CaV 2.1 preference.

CACNA1A CACNA1B

5.80e-07227238155373
Pubmed

Synthetic Aβ oligomers (Aβ(1-42) globulomer) modulate presynaptic calcium currents: prevention of Aβ-induced synaptic deficits by calcium channel blockers.

CACNA1A CACNA1B

5.80e-07227223376566
Pubmed

Distinct roles for Cav2.1-2.3 in activity-dependent synaptic dynamics.

CACNA1A CACNA1B

1.74e-06327224523520
Pubmed

Ankyrin-B regulates Cav2.1 and Cav2.2 channel expression and targeting.

CACNA1A CACNA1B

1.74e-06327224394417
Pubmed

The intracellular C-terminus confers compartment-specific targeting of voltage-gated calcium channels.

CACNA1A CACNA1B

1.74e-06327238996073
Pubmed

Molecular moieties masking Ca2+-dependent facilitation of voltage-gated Cav2.2 Ca2+ channels.

CACNA1A CACNA1B

1.74e-06327229208674
Pubmed

Molecular Basis of Regulating High Voltage-Activated Calcium Channels by S-Nitrosylation.

CACNA1A CACNA1B

1.74e-06327226507659
Pubmed

Munc13-3 Is Required for the Developmental Localization of Ca2+ Channels to Active Zones and the Nanopositioning of Cav2.1 Near Release Sensors.

CACNA1A CACNA1B

1.74e-06327229466725
Pubmed

A protein phosphatase 2calpha-Ca2+ channel complex for dephosphorylation of neuronal Ca2+ channels phosphorylated by protein kinase C.

CACNA1A CACNA1B

3.48e-06427215728831
Pubmed

Synapse and Active Zone Assembly in the Absence of Presynaptic Ca2+ Channels and Ca2+ Entry.

CACNA1A CACNA1B

3.48e-06427232616470
Pubmed

Constitutive and ghrelin-dependent GHSR1a activation impairs CaV2.1 and CaV2.2 currents in hypothalamic neurons.

CACNA1A CACNA1B

3.48e-06427226283199
Pubmed

Cerebellar granule cell signaling is indispensable for normal motor performance.

CACNA1A CACNA1B

3.48e-06427237141091
Pubmed

Interactions of Rabconnectin-3 with Cav2 calcium channels.

CACNA1A CACNA1B

3.48e-06427231253182
Pubmed

G protein-gated inhibitory module of N-type (ca(v)2.2) ca2+ channels.

CACNA1A CACNA1B

3.48e-06427215953418
Pubmed

The MAP1B-LC1/UBE2L3 complex catalyzes degradation of cell surface CaV2.2 channels.

CACNA1A CACNA1B

3.48e-06427225483588
Pubmed

Chromosomal localization of the human genes for alpha 1A, alpha 1B, and alpha 1E voltage-dependent Ca2+ channel subunits.

CACNA1A CACNA1B

5.80e-0652728825650
Pubmed

Functional disorders of the sympathetic nervous system in mice lacking the alpha 1B subunit (Cav 2.2) of N-type calcium channels.

CACNA1A CACNA1B

5.80e-06527211296258
Pubmed

Identification of a cardiac isoform of the murine calcium channel alpha1C (Cav1.2-a) subunit and its preferential binding with the beta2 subunit.

CACNA1A CACNA1B

5.80e-06527216787652
Pubmed

Antinociceptive effect of different types of calcium channel inhibitors and the distribution of various calcium channel alpha 1 subunits in the dorsal horn of spinal cord in mice.

CACNA1A CACNA1B

5.80e-06527215451373
Pubmed

Alpha-neurexins couple Ca2+ channels to synaptic vesicle exocytosis.

CACNA1A CACNA1B

8.69e-06627212827191
Pubmed

beta subunit reshuffling modifies N- and P/Q-type Ca2+ channel subunit compositions in lethargic mouse brain.

CACNA1A CACNA1B

8.69e-06627210328888
Pubmed

An action potential initiation mechanism in distal axons for the control of dopamine release.

CACNA1A CACNA1B

8.69e-06627235324301
Pubmed

Direct interaction of gbetagamma with a C-terminal gbetagamma-binding domain of the Ca2+ channel alpha1 subunit is responsible for channel inhibition by G protein-coupled receptors.

CACNA1A CACNA1B

8.69e-0662729238069
Pubmed

Rebuilding essential active zone functions within a synapse.

CACNA1A CACNA1B

1.22e-05727235176221
Pubmed

International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels.

CACNA1A CACNA1B

2.08e-05927216382099
Pubmed

Rescuing the aberrant sex development of H3K9 demethylase Jmjd1a-deficient mice by modulating H3K9 methylation balance.

FOXL2 USP9Y

3.81e-051227228949961
Pubmed

BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.

RSBN1 TAOK3 MDN1 HNRNPUL1 DHX37 FAM83H DDX10

5.04e-05131827730463901
Pubmed

Calcium channels link the muscle-derived synapse organizer laminin β2 to Bassoon and CAST/Erc2 to organize presynaptic active zones.

CACNA1A CACNA1B

5.25e-051427221228161
Pubmed

Differential neuronal targeting of a new and two known calcium channel β4 subunit splice variants correlates with their regulation of gene expression.

CACNA1A CACNA1B

6.06e-051527224453333
Pubmed

Voltage-activated calcium channel expression profiles in mouse brain and cultured hippocampal neurons.

CACNA1A CACNA1B

6.06e-051527220188150
Pubmed

The HIV-1 envelope protein gp120 impairs B cell proliferation by inducing TGF-β1 production and FcRL4 expression.

FOXL2 STK17A TIPARP

1.08e-0411927324162774
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

MDN1 HNRNPUL1 DHX37 ATAD2B DDX10

1.32e-0465327522586326
Pubmed

Patterned expression of ion channel genes in mouse dorsal raphe nucleus determined with the Allen Mouse Brain Atlas.

CACNA1A CACNA1B

1.59e-042427222534482
Pubmed

The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.

RSBN1 MDN1 HNRNPUL1 DHX37 DDX10

2.65e-0475927535915203
Pubmed

Ion channel expression in the developing enteric nervous system.

CACNA1A CACNA1B

3.80e-043727225798587
Pubmed

Maternal Transient Receptor Potential Vanilloid 6 (Trpv6) Is Involved In Offspring Bone Development.

CACNA1A CACNA1B

4.01e-043827230786075
Pubmed

FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.

TAOK3 MDN1 USP9Y DHX37

5.57e-0449727436774506
CytobandXp11.23

TBC1D25 CHST7

1.44e-0395272Xp11.23
GeneFamilyCalcium voltage-gated channel subunits

CACNA1A CACNA1B

3.35e-0426192253
GeneFamilyAAA ATPases

MDN1 ATAD2B

1.40e-0353192413
CoexpressionNAKAYA_PBMC_FLUARIX_FLUVIRIN_AGE_18_50YO_CORRELATED_WITH_HAI_28DY_RESPONSE_AT_3DY_NEGATIVE

RSBN1 BEX4 SMIM19 STK17A TIPARP

3.11e-05363275M41103
CoexpressionGSE32986_UNSTIM_VS_CURDLAN_HIGHDOSE_STIM_DC_DN

CYP4V2 CHST7 SMIM19 SLC25A45

5.03e-05200274M8618
CoexpressionGSE32986_UNSTIM_VS_GMCSF_AND_CURDLAN_LOWDOSE_STIM_DC_DN

CYP4V2 CHST7 SMIM19 SLC25A45

5.03e-05200274M8620
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW23-Neuronal-Intermediate|GW23 / Sample Type, Dataset, Time_group, and Cell type.

CYP4V2 CHST7 TIPARP SLC25A45

6.14e-06200274fe772d98c461c973dfc082e1fc50117c27ced804
DrugAC 110

CACNA1A CACNA1B

8.11e-064272CID000022860
DrugELAN

CACNA1A CACNA1B FOXL2

1.12e-0537273CID000009469
DrugS 8510

CACNA1A CACNA1B

1.35e-055272CID005488383
Drugalpha-sialylcholesterol

CACNA1A CACNA1B

2.03e-056272CID000133976
Drug3,4-dihydroquinazoline

CACNA1A CACNA1B

2.03e-056272CID000583065
DrugAPMPA

CACNA1A CACNA1B

2.83e-057272CID000512300
Drug4-aminopiperidine

CACNA1A CACNA1B

7.40e-0511272CID000424361
Drugleys

CACNA1A CACNA1B

7.40e-0511272CID000484683
DrugAC1L2VU3

CACNA1A CACNA1B

8.87e-0512272CID000129572
Drugglufosinate

CACNA1A CACNA1B DDX10

9.87e-0576273CID000004794
DrugAC1L1JG6

CACNA1A CACNA1B

1.22e-0414272CID000005026
Drugbutamben

CACNA1A CACNA1B

1.41e-0415272CID000002482
Drugpentasulfane

CACNA1A CACNA1B

1.61e-0416272CID000448216
DrugVerapamil

CACNA1A CACNA1B

1.61e-0416272DB00661
Drugpranidipine

CACNA1A CACNA1B

2.29e-0419272CID006436048
DrugN6-Me-dAdo

CACNA1A CACNA1B

2.29e-0419272CID000168948
Diseasefamilial hemiplegic migraine 1 (implicated_via_orthology)

CACNA1A CACNA1B

2.24e-063262DOID:0111181 (implicated_via_orthology)
Diseasemigraine (implicated_via_orthology)

CACNA1A CACNA1B

4.47e-064262DOID:6364 (implicated_via_orthology)
Diseasehereditary ataxia (implicated_via_orthology)

CACNA1A CACNA1B

1.56e-057262DOID:0050951 (implicated_via_orthology)
Diseasecerebellar ataxia (implicated_via_orthology)

CACNA1A PNPLA7

2.08e-058262DOID:0050753 (implicated_via_orthology)
Diseaseinsulin sensitivity measurement, glucose homeostasis measurement

TAOK3 DDX10

6.59e-0443262EFO_0004471, EFO_0006896
DiseaseParkinson disease

CACNA1B GXYLT1 RETREG3

2.75e-03321263MONDO_0005180
Diseasewellbeing measurement

CACNA1A RSBN1 TAOK3 ATAD2B

2.97e-03692264EFO_0007869
Diseasedepressive symptom measurement

CACNA1A TAOK3 ATAD2B

6.07e-03426263EFO_0007006

Protein segments in the cluster

PeptideGeneStartEntry
KERRMRFYIRRMVKT

CACNA1A

471

O00555
KRKTREQQMRHYMRF

BEX4

91

Q9NWD9
RKEKMFRFFIRRMVK

CACNA1B

466

Q00975
KEYMNRKMFGRDRII

TIPARP

511

Q7Z3E1
VRYGRRRMKLRDLME

MDN1

136

Q9NU22
ENMDMYSRVKRRRKS

ATAD2B

226

Q9ULI0
DMFEKGNYRRRRRMK

FOXL2

136

P58012
EKYRRTGNMARVMVR

GLYATL1

236

Q969I3
RMRRKYFKNDMTTVR

GXYLT1

281

Q4G148
LKMYNRKMRTRRELE

NCMAP

51

Q5T1S8
RKRDKVMFYGRKIMR

PNPLA7

51

Q6ZV29
RMQARMRGFQARKRY

MYO15B

361

Q96JP2
RAVYRMSEMIFRRIK

CYP4V2

221

Q6ZWL3
MAEANPRRGKMRFRR

MCF2

1

P10911
QMRRMEVYNEFVRKR

DDX10

351

Q13206
RRMESMRKEKRVYSR

FAM83H

1121

Q6ZRV2
RYKAMMEIRRLRGQL

DHX37

881

Q8IY37
KMRVMGLRRQRNYAG

HNRNPUL1

461

Q9BUJ2
KHREDMRGRRLKMYN

RSBN1

261

Q5VWQ0
GRERMDYMKRKSREY

TBC1D25

251

Q3MII6
ELREQMSGYKRMRRQ

TAOK3

456

Q9H2K8
FMRKRRKGQDCRMEI

STK17A

91

Q9UEE5
MKGRRRRRREYCKFA

CHST7

1

Q9NS84
RGYMMSKQRERQLRR

RETREG3

231

Q86VR2
KSRMQMDGLRRRVYQ

SLC25A45

226

Q8N413
MYAKRNKRRIMRIFS

SMIM19

41

Q96E16
RERKLIAKRRSYMMD

USP9Y

751

O00507