Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	protein serine kinase activity	STK3 LATS2 MAPKAPK5 MTOR	1.56e-03	363	28	4	GO:0106310
GeneOntologyMolecularFunction	transferase activity, transferring phosphorus-containing groups	STK3 PARP10 LATS2 MAPKAPK5 MTOR PI4KA	1.64e-03	938	28	6	GO:0016772
GeneOntologyMolecularFunction	phosphotransferase activity, alcohol group as acceptor	STK3 LATS2 MAPKAPK5 MTOR PI4KA	2.77e-03	709	28	5	GO:0016773
GeneOntologyMolecularFunction	protein serine/threonine kinase activity	STK3 LATS2 MAPKAPK5 MTOR	3.29e-03	446	28	4	GO:0004674
GeneOntologyMolecularFunction	kinase activity	STK3 LATS2 MAPKAPK5 MTOR PI4KA	3.82e-03	764	28	5	GO:0016301
GeneOntologyMolecularFunction	calmodulin binding	TRPV6 MYH9 MAPKAPK5	4.00e-03	230	28	3	GO:0005516
Domain	PI3/4_kinase_CS	MTOR PI4KA	2.25e-04	15	28	2	IPR018936
Domain	PI3Kc	MTOR PI4KA	2.57e-04	16	28	2	SM00146
Domain	-	MTOR PI4KA	2.57e-04	16	28	2	1.10.1070.11
Domain	PI3_4_KINASE_1	MTOR PI4KA	3.27e-04	18	28	2	PS00915
Domain	PI3_4_KINASE_2	MTOR PI4KA	3.27e-04	18	28	2	PS00916
Domain	PI3/4_kinase_cat_dom	MTOR PI4KA	3.27e-04	18	28	2	IPR000403
Domain	PI3_PI4_kinase	MTOR PI4KA	3.27e-04	18	28	2	PF00454
Domain	PI3_4_KINASE_3	MTOR PI4KA	3.27e-04	18	28	2	PS50290
Domain	Serpin_CS	SERPINC1 SERPINA4	1.05e-03	32	28	2	IPR023795
Domain	Kinase-like_dom	STK3 LATS2 MAPKAPK5 MTOR PI4KA	1.14e-03	542	28	5	IPR011009
Domain	Serpin_dom	SERPINC1 SERPINA4	1.32e-03	36	28	2	IPR023796
Domain	SERPIN	SERPINC1 SERPINA4	1.40e-03	37	28	2	SM00093
Domain	SERPIN	SERPINC1 SERPINA4	1.40e-03	37	28	2	PS00284
Domain	Serpin	SERPINC1 SERPINA4	1.47e-03	38	28	2	PF00079
Domain	Serpin_fam	SERPINC1 SERPINA4	1.55e-03	39	28	2	IPR000215
Domain	Nucleotide-bd_a/b_plait	PARP10 U2SURP HNRNPM	6.61e-03	258	28	3	IPR012677
Pathway	WP_TRANSCRIPTION_COFACTORS_SKI_AND_SKIL_PROTEIN_PARTNERS	STK3 LATS2	3.50e-04	18	22	2	M39825
Pathway	REACTOME_SIGNALING_BY_HIPPO	STK3 LATS2	4.34e-04	20	22	2	MM14813
Pathway	REACTOME_SIGNALING_BY_HIPPO	STK3 LATS2	4.34e-04	20	22	2	M591
Pathway	WP_HIPPO_SIGNALING_REGULATION	STK3 LATS2 MTOR	4.56e-04	98	22	3	M39830
Pathway	WP_HIPPOYAP_SIGNALING	STK3 LATS2	5.27e-04	22	22	2	M39821
Pubmed	Hippo/Mst signalling couples metabolic state and immune function of CD8α+ dendritic cells.	STK3 LATS2 MTOR	7.68e-08	11	28	3	29849151
Pubmed	An FAK-YAP-mTOR Signaling Axis Regulates Stem Cell-Based Tissue Renewal in Mice.	STK3 LATS2 MTOR	2.11e-07	15	28	3	28457749
Pubmed	NMIIA promotes tumorigenesis and prevents chemosensitivity in colorectal cancer by activating AMPK/mTOR pathway.	MYH9 MTOR	6.25e-07	2	28	2	33220257
Pubmed	Lysophosphatidic acid acyltransferase beta regulates mTOR signaling.	MTOR AGPAT2	1.87e-06	3	28	2	24205284
Pubmed	Inactivation of Rheb by PRAK-mediated phosphorylation is essential for energy-depletion-induced suppression of mTORC1.	MAPKAPK5 MTOR	1.87e-06	3	28	2	21336308
Pubmed	The characterisation of LATS2 kinase regulation in Hippo-YAP signalling.	STK3 LATS2	3.75e-06	4	28	2	26898830
Pubmed	Mst2 and Lats kinases regulate apoptotic function of Yes kinase-associated protein (YAP).	STK3 LATS2	6.24e-06	5	28	2	18640976
Pubmed	Roles of mammalian sterile 20-like kinase 2-dependent phosphorylations of Mps one binder 1B in the activation of nuclear Dbf2-related kinases.	STK3 LATS2	6.24e-06	5	28	2	19919647
Pubmed	Proteome-wide identification of HSP70/HSC70 chaperone clients in human cells.	KDM3B PARP10 AP1M1 MYH9 MTOR SLC1A4 HNRNPM AHCY	8.58e-06	1367	28	8	32687490
Pubmed	The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1.	STK3 LATS2	9.36e-06	6	28	2	15688006
Pubmed	Lysine demethylase 2 (KDM2B) regulates hippo pathway via MOB1 to promote pancreatic ductal adenocarcinoma (PDAC) progression.	STK3 LATS2	9.36e-06	6	28	2	31941533
Pubmed	Hippo signaling impedes adult heart regeneration.	STK3 LATS2	1.31e-05	7	28	2	24255096
Pubmed	A Stk4-Foxp3-NF-κB p65 transcriptional complex promotes Treg cell activation and homeostasis.	STK3 LATS2	1.74e-05	8	28	2	36149942
Pubmed	Hippo/Mst signaling coordinates cellular quiescence with terminal maturation in iNKT cell development and fate decisions.	STK3 LATS2	1.74e-05	8	28	2	32289155
Pubmed	Hippo pathway-dependent and -independent roles of RASSF6.	STK3 LATS2	1.74e-05	8	28	2	19797269
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	KDM3B JADE1 LATS2 MAPKAPK5 MTOR PI4KA AGPAT2	2.11e-05	1105	28	7	35748872
Pubmed	The ATG5 interactome links clathrin-mediated vesicular trafficking with the autophagosome assembly machinery.	AP1M1 CC2D1B INPP4A PI4KA	3.37e-05	230	28	4	35449600
Pubmed	Hippo Signaling Suppresses Cell Ploidy and Tumorigenesis through Skp2.	STK3 LATS2	3.42e-05	11	28	2	28486106
Pubmed	WWC proteins mediate LATS1/2 activation by Hippo kinases and imply a tumor suppression strategy.	STK3 LATS2	4.10e-05	12	28	2	35429439
Pubmed	MEKK2 and MEKK3 orchestrate multiple signals to regulate Hippo pathway.	STK3 LATS2	4.85e-05	13	28	2	33571521
Pubmed	The Hippo pathway regulates Wnt/beta-catenin signaling.	STK3 LATS2	4.85e-05	13	28	2	20412773
Pubmed	DLG5 connects cell polarity and Hippo signaling protein networks by linking PAR-1 with MST1/2.	STK3 LATS2	5.65e-05	14	28	2	28087714
Pubmed	Optimized fragmentation schemes and data analysis strategies for proteome-wide cross-link identification.	MYH9 MTOR TRABD PI4KA U2SURP	6.37e-05	538	28	5	28524877
Pubmed	Proteomic analysis of an interactome for long-form AMPA receptor subunits.	MYH9 HNRNPM	6.52e-05	15	28	2	20131911
Pubmed	Regenerative Reprogramming of the Intestinal Stem Cell State via Hippo Signaling Suppresses Metastatic Colorectal Cancer.	STK3 LATS2	7.45e-05	16	28	2	32730753
Pubmed	A Noncanonical Role of Fructose-1, 6-Bisphosphatase 1 Is Essential for Inhibition of Notch1 in Breast Cancer.	MYH9 U2SURP HNRNPM AHCY	7.85e-05	286	28	4	32041737
Pubmed	Early-onset ischaemic stroke: analysis of 58 polymorphisms in 17 genes involved in methionine metabolism.	ENOSF1 AHCY	8.44e-05	17	28	2	20458436
Pubmed	Genetic analysis of 56 polymorphisms in 17 genes involved in methionine metabolism in patients with abdominal aortic aneurysm.	ENOSF1 AHCY	8.44e-05	17	28	2	18635682
Pubmed	Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo.	MTOR PI4KA	8.44e-05	17	28	2	25327288
Pubmed	High-throughput multiplex single-nucleotide polymorphism (SNP) analysis in genes involved in methionine metabolism.	ENOSF1 AHCY	8.44e-05	17	28	2	18427977
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	AP1M1 MYH9 MTOR PI4KA U2SURP HNRNPM AHCY	1.06e-04	1425	28	7	30948266
Pubmed	CLEC16A interacts with retromer and TRIM27, and its loss impairs endosomal trafficking and neurodevelopment.	STK3 TOR2A MTOR TRABD PI4KA	1.11e-04	606	28	5	36538041
Pubmed	A high-throughput approach for measuring temporal changes in the interactome.	KDM3B AP1M1 CC2D1B MYH9 MTOR HNRNPM AHCY	1.21e-04	1455	28	7	22863883
Pubmed	Hippo pathway inhibits Wnt signaling to restrain cardiomyocyte proliferation and heart size.	STK3 LATS2	1.43e-04	22	28	2	21512031
Pubmed	Suppression of ACE2 SUMOylation protects against SARS-CoV-2 infection through TOLLIP-mediated selective autophagy.	AP1M1 MYH9 U2SURP HNRNPM AHCY	1.45e-04	641	28	5	36057605
Pubmed	A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.	KDM3B STK3 AP1M1 DHX35 MTOR HNRNPM	1.49e-04	1038	28	6	26673895
Pubmed	∆F508 CFTR interactome remodelling promotes rescue of cystic fibrosis.	SERPINC1 MYH9 MTOR HNRNPM AHCY	1.51e-04	647	28	5	26618866
Pubmed	KSHV episome tethering sites on host chromosomes and regulation of latency-lytic switch by CHD4.	KDM3B U2SURP HNRNPM	1.56e-04	130	28	3	35545047
Pubmed	RUFY1 binds Arl8b and mediates endosome-to-TGN CI-M6PR retrieval for cargo sorting to lysosomes.	AP1M1 MYH9 HNRNPM AHCY	1.60e-04	344	28	4	36282215
Pubmed	ZZW-115-dependent inhibition of NUPR1 nuclear translocation sensitizes cancer cells to genotoxic agents.	SERPINC1 MYH9 PI4KA U2SURP HNRNPM	1.66e-04	660	28	5	32780723
Pubmed	The Crumbs complex couples cell density sensing to Hippo-dependent control of the TGF-β-SMAD pathway.	STK3 LATS2	1.85e-04	25	28	2	21145499
Pubmed	mTORC1-Regulated and HUWE1-Mediated WIPI2 Degradation Controls Autophagy Flux.	AP1M1 MTOR	1.85e-04	25	28	2	30340022
Pubmed	A chemical tool for blue light-inducible proximity photo-crosslinking in live cells.	MTOR AHCY	1.85e-04	25	28	2	35211260
Pubmed	Crucial role for Mst1 and Mst2 kinases in early embryonic development of the mouse.	STK3 LATS2	1.85e-04	25	28	2	19786569
Pubmed	Homeostatic and tumourigenic activity of SOX2+ pituitary stem cells is controlled by the LATS/YAP/TAZ cascade.	STK3 LATS2	1.85e-04	25	28	2	30912742
Pubmed	A directed protein interaction network for investigating intracellular signal transduction.	STK3 SERPINA4 JADE1 MAPKAPK5 MTOR PI4KA	2.30e-04	1124	28	6	21900206
Pubmed	A conserved MST1/2-YAP axis mediates Hippo signaling during lung growth.	STK3 LATS2	2.33e-04	28	28	2	25912685
Pubmed	Proteomics analysis of nucleolar SUMO-1 target proteins upon proteasome inhibition.	MYH9 HNRNPM	2.33e-04	28	28	2	19596686
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	AP1M1 MYH9 SLC1A4 PI4KA U2SURP HNRNPM	2.47e-04	1139	28	6	36417873
Pubmed	LATS-YAP/TAZ controls lineage specification by regulating TGFβ signaling and Hnf4α expression during liver development.	STK3 LATS2	2.50e-04	29	28	2	27358050
Pubmed	Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers.	KDM3B STK3 LATS2 TOR2A AHCY	2.65e-04	730	28	5	34857952
Pubmed	Mapping the MOB proteins' proximity network reveals a unique interaction between human MOB3C and the RNase P complex.	KDM3B STK3 LATS2 AHCY	2.81e-04	399	28	4	37536630
Pubmed	Defining the membrane proteome of NK cells.	AP1M1 MYH9 MTOR SLC1A4 PI4KA HNRNPM	2.83e-04	1168	28	6	19946888
Pubmed	Characterization of molecules binding to the 70K N-terminal region of fibronectin by IFAST purification coupled with mass spectrometry.	SERPINA4 MYH9	3.05e-04	32	28	2	23750785
Pubmed	A quantitative analysis of the spatiotemporal pattern of transient receptor potential gene expression in the developing mouse cochlea.	TRPV6 PKDREJ	3.25e-04	33	28	2	19834762
Pubmed	Proteomic analysis reveals novel binding partners of MIP-T3 in human cells.	MYH9 AHCY	3.45e-04	34	28	2	20391533
Pubmed	A critical role for NF2 and the Hippo pathway in branching morphogenesis.	STK3 LATS2	3.87e-04	36	28	2	27480037
Pubmed	TIF1γ inhibits lung adenocarcinoma EMT and metastasis by interacting with the TAF15/TBP complex.	MYH9 U2SURP HNRNPM	3.99e-04	179	28	3	36261009
Pubmed	Identification of proximal SUMO-dependent interactors using SUMO-ID.	KDM3B MYH9 HNRNPM AHCY	4.21e-04	444	28	4	34795231
Pubmed	Cellular RNA binding proteins NS1-BP and hnRNP K regulate influenza A virus RNA splicing.	MYH9 HNRNPM	4.78e-04	40	28	2	23825951
Pubmed	Citron kinase interacts with LATS2 and inhibits its activity by occluding its hydrophobic phosphorylation motif.	MYH9 LATS2	4.78e-04	40	28	2	30865227
Pubmed	Quantitative nanoproteomics for protein complexes (QNanoPX) related to estrogen transcriptional action.	MYH9 HNRNPM	5.03e-04	41	28	2	19805454
Pubmed	PINK1 Content in Mitochondria is Regulated by ER-Associated Degradation.	MYH9 U2SURP HNRNPM AHCY	5.51e-04	477	28	4	31300519
Pubmed	Update of the human and mouse SERPIN gene superfamily.	SERPINC1 SERPINA4	5.53e-04	43	28	2	24172014
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	KDM3B STK3 AP1M1 MTOR PI4KA	5.63e-04	861	28	5	36931259
Pubmed	LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.	MYH9 MTOR PI4KA	5.68e-04	202	28	3	33005030
Pubmed	Developmental waves of mechanosensitivity acquisition in sensory neuron subtypes during embryonic development.	TRPV6 PKDREJ	5.79e-04	44	28	2	19322198
Pubmed	AMPK, a Regulator of Metabolism and Autophagy, Is Activated by Lysosomal Damage via a Novel Galectin-Directed Ubiquitin Signal Transduction System.	MYH9 SLC1A4 HNRNPM AHCY	5.82e-04	484	28	4	31995728
Pubmed	Inhibition of calpain 1 restores plasma membrane stability to pharmacologically rescued Phe508del-CFTR variant.	DHX35 MYH9 HNRNPM AHCY	6.00e-04	488	28	4	31324722
Pubmed	A HIV-1 Tat mutant protein disrupts HIV-1 Rev function by targeting the DEAD-box RNA helicase DDX1.	MYH9 HNRNPM	6.06e-04	45	28	2	25496916
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	AP1M1 MYH9 PI4KA U2SURP HNRNPM AHCY	6.18e-04	1353	28	6	29467282
Pubmed	ZF21 is a new regulator of focal adhesion disassembly and a potential member of the spreading initiation center.	MYH9 HNRNPM	6.33e-04	46	28	2	20890123
Pubmed	A Genome-wide ER-phagy Screen Highlights Key Roles of Mitochondrial Metabolism and ER-Resident UFMylation.	MYH9 HNRNPM	6.61e-04	47	28	2	32160526
Pubmed	Nuclear actin interactome analysis links actin to KAT14 histone acetyl transferase and mRNA splicing.	KDM3B MYH9 U2SURP HNRNPM	6.87e-04	506	28	4	30890647
Pubmed	New interaction partners for Nek4.1 and Nek4.2 isoforms: from the DNA damage response to RNA splicing.	MYH9 SLC1A4 U2SURP HNRNPM	7.23e-04	513	28	4	25798074
Pubmed	TRIM33 drives prostate tumor growth by stabilizing androgen receptor from Skp2-mediated degradation.	KDM3B U2SURP HNRNPM	7.28e-04	220	28	3	35785414
Pubmed	Global analysis of TDP-43 interacting proteins reveals strong association with RNA splicing and translation machinery.	MYH9 U2SURP HNRNPM	7.57e-04	223	28	3	20020773
Cytoband	Ensembl 112 genes in cytogenetic band chr8q22	STK3 TMEM67	4.73e-03	168	28	2	chr8q22
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	CC2D1B INPP4A	4.55e-04	36	16	2	823
GeneFamily	Serpin peptidase inhibitors	SERPINC1 SERPINA4	4.80e-04	37	16	2	739
GeneFamily	RNA binding motif containing	U2SURP HNRNPM	1.49e-02	213	16	2	725
Drug	methiin	SERPINA4 MTOR	8.11e-06	4	27	2	CID000082142
Drug	utyramide	SERPINC1 SERPINA4 PI4KA	2.33e-05	47	27	3	CID000461280
Drug	SAHA; Down 200; 10uM; HL60; HT_HG-U133A	KDM3B ENOSF1 JADE1 TRABD	5.27e-05	176	27	4	6179_DN
Drug	Trichostatin A, Streptomyces sp.; Down 200; 1uM; HL60; HT_HG-U133A	KDM3B ENOSF1 JADE1 SLC1A4	5.63e-05	179	27	4	1175_DN
Drug	ICI 182,780; Down 200; 0.01uM; PC3; HT_HG-U133A	STK3 TRPV6 SLC1A4 INPP4A	7.39e-05	192	27	4	4462_DN
Drug	Meclofenamic acid sodium salt monohydrate [6385-02-0]; Down 200; 11.8uM; MCF7; HT_HG-U133A	DHX35 INPP4A U2SURP AGPAT2	8.16e-05	197	27	4	7038_DN
Drug	Trichostatin A, from Streptomyces sp.; Down 200; 0.1uM; MCF7; HT_HG-U133A	STK3 SLC1A4 INPP4A TRABD	8.32e-05	198	27	4	3332_DN
Drug	Cinnarizine [298-57-7]; Down 200; 10.8uM; MCF7; HT_HG-U133A	JADE1 MTOR SLC1A4 INPP4A	8.32e-05	198	27	4	7174_DN
Drug	Isoniazid [54-85-3]; Up 200; 29.2uM; MCF7; HT_HG-U133A	STK3 INPP4A U2SURP AGPAT2	8.32e-05	198	27	4	7197_UP
Drug	Alfaxalone [23930-19-0]; Down 200; 12uM; MCF7; HT_HG-U133A	TRPV6 SLC1A4 INPP4A U2SURP	8.32e-05	198	27	4	5451_DN
Drug	Nifedipine [21829-25-4]; Down 200; 11.6uM; MCF7; HT_HG-U133A	STK3 INPP4A TRABD AGPAT2	8.49e-05	199	27	4	6006_DN
Drug	F-ddA	ENOSF1 AHCY	8.87e-05	12	27	2	CID000072180
Disease	autosomal recessive polycystic kidney disease (implicated_via_orthology)	TMEM67 MTOR	8.21e-05	16	25	2	DOID:0110861 (implicated_via_orthology)
Disease	neurodegenerative disease (implicated_via_orthology)	STK3 LATS2 SLC1A4	2.47e-04	145	25	3	DOID:1289 (implicated_via_orthology)
Disease	Intellectual Disability	KDM3B MTOR SLC1A4 INPP4A	5.11e-04	447	25	4	C3714756
Disease	response to hydrochlorothiazide, fasting blood glucose measurement	STK3 JADE1	6.97e-04	46	25	2	EFO_0004465, EFO_0005202
Disease	carcinoma (implicated_via_orthology)	STK3 LATS2	1.35e-03	64	25	2	DOID:305 (implicated_via_orthology)
Disease	cancer (implicated_via_orthology)	STK3 LATS2 MTOR	1.47e-03	268	25	3	DOID:162 (implicated_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
EHFMPILMEKEEEGM	AP1M1	31	Q9BXS5
DELEEMMLVVHMPRF	SERPINC1	341	P01008
LAMLEDMSLGIMDLR	INPP4A	726	Q96PE3
LEDQPMDMLLGLDML	DDI1	321	Q8WTU0
ARLLIVMEMMEGGEL	MAPKAPK5	96	Q8IW41
GDMMSLLIRMEVFPE	LATS2	751	Q9NRM7
ERMGPAIERMGLSME	HNRNPM	516	P52272
IIRDMIGPEKTLMMD	ENOSF1	236	Q7L5Y1
EPDIKLTDEMVMIMG	PI4KA	1991	P42356
DMMPTRFEDLMENLP	KDM3B	1496	Q7LBC6
ETMEAMRIMGIPEEE	MYH9	321	P35579
MRIMGIPEEEQMGLL	MYH9	326	P35579
FLTDGMLVREMMVDP	DHX35	151	Q9H5Z1
LFMEFGPEDMLLGMD	CC2D1B	26	Q5T0F9
ALDIAENEMPGLMRM	AHCY	21	P23526
ILDMMGLMEVLPERC	AGPAT2	101	O15120
EGLVEMVLLMEPGAM	PARP10	441	Q53GL7
LLERILGMEFMEPME	TMEM67	901	Q5HYA8
GMFEVLEPLHAMMER	MTOR	2046	P42345
DEMDKMPPGLMEVLR	TOR2A	161	Q8N2E6
MREIEEVLTPEMLMR	SERPINA4	286	P29622
TEIRLDGMRMHPEEM	PKDREJ	1656	Q9NTG1
MGMPELDEYTMERVL	JADE1	161	Q6IE81
EFVVREGPMFEAMIM	U2SURP	436	O15042
DEMDKMPPGLMEVLR	TOR2A	161	Q5JU69
EELQMRLKALDPMME	STK3	446	Q13188
AFPGEMLLRMLRMII	SLC1A4	76	P43007
LLEQMMAEMIGEFPD	TRABD	236	Q9H4I3
MVLMEAAPELVFEPM	TRPV6	136	Q9H1D0
MEMFVRMVNVLEPDI	TMPPE	226	Q6ZT21