Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionextracellular matrix structural constituent

LAMA4 LAMA5 SSPOP MUC5AC

1.50e-04188294GO:0005201
GeneOntologyMolecularFunctionprotein-hormone receptor activity

IGF1R LGR6

4.62e-0422292GO:0016500
GeneOntologyBiologicalProcesscellular response to ketone

SCNN1A IGF1R ADCY3 AXIN2

2.74e-05130284GO:1901655
GeneOntologyBiologicalProcessodontogenesis

JAG2 MUC19 LAMA5 AXIN2

4.93e-05151284GO:0042476
GeneOntologyBiologicalProcessexocrine system development

MUC19 LAMA5 IGF1R

6.24e-0557283GO:0035272
GeneOntologyBiologicalProcesscellular response to aldosterone

SCNN1A IGF1R

6.36e-059282GO:1904045
GeneOntologyBiologicalProcesscellular response to mineralocorticoid stimulus

SCNN1A IGF1R

1.60e-0414282GO:0071389
GeneOntologyBiologicalProcesscellular response to corticosteroid stimulus

SCNN1A IGF1R AXIN2

1.78e-0481283GO:0071384
GeneOntologyBiologicalProcesscellular response to steroid hormone stimulus

SCNN1A IGF1R CNOT1 AXIN2

2.89e-04239284GO:0071383
GeneOntologyBiologicalProcessresponse to aldosterone

SCNN1A IGF1R

3.33e-0420282GO:1904044
GeneOntologyBiologicalProcesscellular response to aldehyde

SCNN1A IGF1R

3.33e-0420282GO:0110096
GeneOntologyBiologicalProcessresponse to ketone

SCNN1A IGF1R ADCY3 AXIN2

3.64e-04254284GO:1901654
GeneOntologyCellularComponentextracellular matrix

LAMA4 LAMA5 LGR6 SSPOP MUC5AC P3H1 LPA FAM20B

2.16e-06656298GO:0031012
GeneOntologyCellularComponentexternal encapsulating structure

LAMA4 LAMA5 LGR6 SSPOP MUC5AC P3H1 LPA FAM20B

2.21e-06658298GO:0030312
GeneOntologyCellularComponentcollagen-containing extracellular matrix

LAMA4 LAMA5 SSPOP P3H1 LPA FAM20B

7.46e-05530296GO:0062023
GeneOntologyCellularComponentbasement membrane

LAMA4 LAMA5 P3H1

6.34e-04122293GO:0005604
GeneOntologyCellularComponentsynaptic cleft

LAMA4 LAMA5

9.55e-0433292GO:0043083
GeneOntologyCellularComponentsperm flagellum

DNAH2 SCNN1A ODF1

3.18e-03214293GO:0036126
GeneOntologyCellularComponent9+2 motile cilium

DNAH2 SCNN1A ODF1

4.28e-03238293GO:0097729
MousePhenoabnormal conjunctival epithelium morphology

MUC5AC LPA

5.90e-057242MP:0004481
MousePhenodecreased dentate gyrus size

ADCY3 KDM4B

7.86e-058242MP:0012460
DomainVWC_out

JAG2 MUC19 SSPOP MUC5AC

1.79e-0819294SM00215
DomainVWC

JAG2 MUC19 SSPOP MUC5AC

3.34e-0738294SM00214
DomainVWFC_2

JAG2 MUC19 SSPOP MUC5AC

3.34e-0738294PS50184
DomainVWF_dom

JAG2 MUC19 SSPOP MUC5AC

5.04e-0742294IPR001007
DomainTIL

MUC19 SSPOP MUC5AC

7.34e-0712293PF01826
DomainC8

MUC19 SSPOP MUC5AC

7.34e-0712293PF08742
DomainUnchr_dom_Cys-rich

MUC19 SSPOP MUC5AC

9.53e-0713293IPR014853
DomainC8

MUC19 SSPOP MUC5AC

9.53e-0713293SM00832
DomainTIL_dom

MUC19 SSPOP MUC5AC

1.21e-0614293IPR002919
DomainVWFD

MUC19 SSPOP MUC5AC

1.86e-0616293PS51233
DomainVWD

MUC19 SSPOP MUC5AC

1.86e-0616293SM00216
DomainVWF_type-D

MUC19 SSPOP MUC5AC

1.86e-0616293IPR001846
DomainVWD

MUC19 SSPOP MUC5AC

1.86e-0616293PF00094
DomainEGF_1

JAG2 SELP LAMA4 LAMA5 SSPOP LRP1B

2.23e-06255296PS00022
DomainCTCK_1

MUC19 SSPOP MUC5AC

2.70e-0618293PS01185
DomainCys_knot_C

MUC19 SSPOP MUC5AC

7.57e-0625293IPR006207
DomainCTCK_2

MUC19 SSPOP MUC5AC

7.57e-0625293PS01225
DomainLaminin_aI

LAMA4 LAMA5

2.32e-055292IPR009254
DomainLaminin_I

LAMA4 LAMA5

2.32e-055292PF06008
DomainLaminin_II

LAMA4 LAMA5

2.32e-055292PF06009
DomainLaminin_domII

LAMA4 LAMA5

2.32e-055292IPR010307
DomainVWFC_1

JAG2 SSPOP MUC5AC

2.32e-0536293PS01208
DomainEGF

JAG2 SELP LAMA4 LAMA5 LRP1B

2.80e-05235295SM00181
DomainEGF-like_dom

JAG2 SELP LAMA4 LAMA5 LRP1B

3.70e-05249295IPR000742
DomainEGF-like_CS

JAG2 SELP LAMA4 LAMA5 LRP1B

4.63e-05261295IPR013032
DomainEGF_2

JAG2 SELP LAMA5 SSPOP LRP1B

4.98e-05265295PS01186
DomainGrowth_fac_rcpt_

JAG2 LAMA5 IGF1R LRP1B

9.45e-05156294IPR009030
DomainEGF_3

JAG2 SELP SSPOP LRP1B

4.53e-04235294PS50026
DomainCT

MUC19 MUC5AC

5.27e-0422292SM00041
DomainEGF

JAG2 SELP LRP1B

9.64e-04126293PF00008
DomainEGF_LAM_2

LAMA4 LAMA5

9.86e-0430292PS50027
DomainEGF_LAM_1

LAMA4 LAMA5

9.86e-0430292PS01248
DomainLaminin_EGF

LAMA4 LAMA5

1.34e-0335292PF00053
DomainEGF_Lam

LAMA4 LAMA5

1.34e-0335292SM00180
DomainLAM_G_DOMAIN

LAMA4 LAMA5

1.58e-0338292PS50025
DomainLaminin_EGF

LAMA4 LAMA5

1.58e-0338292IPR002049
DomainLaminin_G_2

LAMA4 LAMA5

1.75e-0340292PF02210
DomainLDLR_class-A_CS

SSPOP LRP1B

1.75e-0340292IPR023415
DomainLamG

LAMA4 LAMA5

2.11e-0344292SM00282
DomainLdl_recept_a

SSPOP LRP1B

2.21e-0345292PF00057
Domain-

SSPOP LRP1B

2.31e-03462924.10.400.10
DomainLDLRA_1

SSPOP LRP1B

2.51e-0348292PS01209
DomainLDrepeatLR_classA_rpt

SSPOP LRP1B

2.62e-0349292IPR002172
DomainLDLa

SSPOP LRP1B

2.62e-0349292SM00192
DomainLDLRA_2

SSPOP LRP1B

2.62e-0349292PS50068
DomainLaminin_G

LAMA4 LAMA5

3.65e-0358292IPR001791
DomainEGF_extracell

JAG2 LRP1B

3.90e-0360292IPR013111
DomainEGF_2

JAG2 LRP1B

3.90e-0360292PF07974
DomainEGF_CA

JAG2 LRP1B

7.85e-0386292PF07645
PathwayWP_CANCER_PATHWAYS

JAG2 LAMA4 LAMA5 IGF1R ADCY3 AXIN2

9.59e-05507226M48302
Pubmed

Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression.

LAMA4 LAMA5 SSPOP LPA FAM20B

3.28e-0717529528071719
Pubmed

Laminins affect T cell trafficking and allograft fate.

LAMA4 LAMA5

6.71e-07229224691446
Pubmed

Laminin isoforms of lymph nodes and predominant role of alpha5-laminin(s) in adhesion and migration of blood lymphocytes.

LAMA4 LAMA5

6.71e-07229218523231
Pubmed

Screening of integrin-binding peptides from the laminin α4 and α5 chain G domain peptide library.

LAMA4 LAMA5

6.71e-07229222391228
Pubmed

Epithelial-mesenchymal transition downregulates laminin alpha5 chain and upregulates laminin alpha4 chain in oral squamous carcinoma cells.

LAMA4 LAMA5

6.71e-07229218496706
Pubmed

Endothelial basement membrane laminin alpha5 selectively inhibits T lymphocyte extravasation into the brain.

LAMA4 LAMA5

6.71e-07229219396173
Pubmed

Peptides derived from the human laminin alpha4 and alpha5 chains exhibit antimicrobial activity.

LAMA4 LAMA5

6.71e-07229220433883
Pubmed

Differential Regulation of T-cell Immunity and Tolerance by Stromal Laminin Expressed in the Lymph Node.

LAMA4 LAMA5

6.71e-07229231343575
Pubmed

Impaired fetal muscle development and JAK-STAT activation mark disease onset and progression in a mouse model for merosin-deficient congenital muscular dystrophy.

LAMA4 LAMA5 AXIN2

7.94e-072229328334989
Pubmed

Constitutive activation of hedgehog signaling adversely affects epithelial cell fate during palatal fusion.

JAG2 LAMA5 AXIN2

9.13e-072329329981310
Pubmed

Notch signaling in stomach epithelial stem cell homeostasis.

JAG2 MUC5AC AXIN2

1.88e-062929321402740
Pubmed

Laminin α2, α4, and α5 Chains Positively Regulate Migration and Survival of Oligodendrocyte Precursor Cells.

LAMA4 LAMA5

2.01e-06329231882770
Pubmed

Endothelial basement membrane laminin 511 is essential for shear stress response.

LAMA4 LAMA5

2.01e-06329227940654
Pubmed

Lgr6 marks nail stem cells and is required for digit tip regeneration.

LGR6 AXIN2

2.01e-06329226460010
Pubmed

Endothelial Basement Membrane Laminin 511 Contributes to Endothelial Junctional Tightness and Thereby Inhibits Leukocyte Transmigration.

LAMA4 LAMA5

2.01e-06329228147279
Pubmed

Laminin isoform-specific promotion of adhesion and migration of human bone marrow progenitor cells.

LAMA4 LAMA5

2.01e-06329212393739
Pubmed

Developmental expression and cellular origin of the laminin alpha2, alpha4, and alpha5 chains in the intestine.

LAMA4 LAMA5

2.01e-06329210364433
Pubmed

The role of laminins in the organization and function of neuromuscular junctions.

LAMA4 LAMA5

2.01e-06329227614294
Pubmed

Mapping the molecular and structural specialization of the skin basement membrane for inter-tissue interactions.

LAMA5 LGR6

4.02e-06429233972551
Pubmed

Notch3 and Jagged2 contribute to gastric cancer development and to glandular differentiation associated with MUC2 and MUC5AC expression.

JAG2 MUC5AC

4.02e-06429222691042
Pubmed

Laminin alpha 5 regulates mammary gland remodeling through luminal cell differentiation and Wnt4-mediated epithelial crosstalk.

LAMA5 LGR6

4.02e-06429234128985
Pubmed

Laminins promote postsynaptic maturation by an autocrine mechanism at the neuromuscular junction.

LAMA4 LAMA5

6.70e-06529218794334
Pubmed

Differential expression of five laminin alpha (1-5) chains in developing and adult mouse kidney.

LAMA4 LAMA5

6.70e-0652929415429
Pubmed

Tissue-specific expression of the human laminin alpha5-chain, and mapping of the gene to human chromosome 20q13.2-13.3 and to distal mouse chromosome 2 near the locus for the ragged (Ra) mutation.

LAMA4 LAMA5

6.70e-0652929271224
Pubmed

Differential expression of laminin alpha chains during murine tooth development.

LAMA4 LAMA5

6.70e-0652929389447
Pubmed

Sox9 plays multiple roles in the lung epithelium during branching morphogenesis.

LAMA4 LAMA5 AXIN2

9.95e-065029324191021
Pubmed

A synaptic nidogen: developmental regulation and role of nidogen-2 at the neuromuscular junction.

LAMA4 LAMA5

1.00e-05629218817539
Pubmed

Expression of Muc19/Smgc gene products during murine sublingual gland development: cytodifferentiation and maturation of salivary mucous cells.

MUC19 MUC5AC

1.00e-05629219110483
Pubmed

HIV-protein-mediated alterations in T cell interactions with the extracellular matrix proteins and endothelium.

LAMA4 LAMA5

1.00e-0562929597096
Pubmed

Laminin isoforms in fetal and adult human adrenal cortex.

LAMA4 LAMA5

1.41e-05729214557481
Pubmed

Reciprocal interaction between mesenchymal stem cells and transit amplifying cells regulates tissue homeostasis.

IGF1R AXIN2

1.41e-05729233480845
Pubmed

Genetic risk factors in recurrent venous thromboembolism: A multilocus, population-based, prospective approach.

SCNN1A SELP LPA

1.48e-055729319263529
Pubmed

Phenotype-genotype interactions on renal function in type 2 diabetes: an analysis using structural equation modelling.

SCNN1A SELP LPA

1.48e-055729319479237
Pubmed

Identification of Lgr5-independent spheroid-generating progenitors of the mouse fetal intestinal epithelium.

LGR6 AXIN2

1.87e-05829224139799
Pubmed

Insulin-like growth factor II receptor, transforming growth factor-beta, and Cdk4 expression and the developmental epigenetics of mouse palate morphogenesis and dysmorphogenesis.

IGF1R LPA

1.87e-0582929438420
Pubmed

Failure of digit tip regeneration in the absence of Lmx1b suggests Lmx1b functions disparate from dorsoventral polarity.

LGR6 AXIN2

1.87e-05829236641754
Pubmed

Roles for laminin in embryogenesis: exencephaly, syndactyly, and placentopathy in mice lacking the laminin alpha5 chain.

LAMA4 LAMA5

1.87e-0582929852162
Pubmed

4D intravital imaging studies identify platelets as the predominant cellular procoagulant surface in a mouse hemostasis model.

SELP LPA

1.87e-05829238820498
Pubmed

A meta-analysis of candidate gene polymorphisms and ischemic stroke in 6 study populations: association of lymphotoxin-alpha in nonhypertensive patients.

SCNN1A SELP LPA

2.10e-056429319131662
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

SCNN1A JAG2 ZFHX2 IGF1R SSPOP CNOT1 ADCY3 KDM4B

2.12e-05148929828611215
Pubmed

Expression of laminin alpha1, alpha2, alpha4, and alpha5 chains, fibronectin, and tenascin-C in skeletal muscle of dystrophic 129ReJ dy/dy mice.

LAMA4 LAMA5

2.41e-0592929882526
Pubmed

Local anesthetics impair the growth and self-renewal of glioblastoma stem cells by inhibiting ZDHHC15-mediated GP130 palmitoylation.

NFXL1 SSPOP MUC5AC

2.87e-057129333541421
Pubmed

Distribution of the ten known laminin chains in the pathways and targets of developing sensory axons.

LAMA4 LAMA5

3.01e-05102929034910
Pubmed

Integrin-laminin interactions controlling neurite outgrowth from adult DRG neurons in vitro.

LAMA4 LAMA5

3.01e-051029218590826
Pubmed

Trophoblast-specific expression and function of the integrin alpha 7 subunit in the peri-implantation mouse embryo.

LAMA4 LAMA5

3.01e-051029211784026
Pubmed

Primary cellular meningeal defects cause neocortical dysplasia and dyslamination.

LAMA4 LAMA5

3.01e-051029220976766
Pubmed

Respiratory distress and perinatal lethality in Nedd4-2-deficient mice.

SCNN1A MUC5AC

3.68e-051129221505443
Pubmed

Laminin alpha 5 is required for lobar septation and visceral pleural basement membrane formation in the developing mouse lung.

LAMA4 LAMA5

3.68e-051129212051813
Pubmed

Regional differences in the expression of laminin isoforms during mouse neural tube development.

LAMA4 LAMA5

3.68e-051129221524702
Pubmed

Mutations in LAMB1 cause cobblestone brain malformation without muscular or ocular abnormalities.

LAMA4 LAMA5

3.68e-051129223472759
Pubmed

Endothelial cell laminin isoforms, laminins 8 and 10, play decisive roles in T cell recruitment across the blood-brain barrier in experimental autoimmune encephalomyelitis.

LAMA4 LAMA5

4.41e-051229211381080
Pubmed

Molecular dissection of laminin alpha 5 in vivo reveals separable domain-specific roles in embryonic development and kidney function.

LAMA4 LAMA5

4.41e-051229216750824
Pubmed

Distribution and function of laminins in the neuromuscular system of developing, adult, and mutant mice.

LAMA4 LAMA5

4.41e-05122929396756
Pubmed

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.

JAG2 LAMA4 LAMA5 IGF1R LRP1B P3H1 FAM20B

4.61e-05120129735696571
Pubmed

The extracellular matrix controls stem cell specification and crypt morphology in the developing and adult mouse gut.

LAMA4 LAMA5

5.21e-051329236350252
Pubmed

Regional regulation of Filiform tongue papillae development by Ikkα/Irf6.

JAG2 AXIN2

5.21e-051329227302476
Pubmed

Fukutin-related protein alters the deposition of laminin in the eye and brain.

LAMA4 LAMA5

5.21e-051329221900571
Pubmed

The laminin alpha chains: expression, developmental transitions, and chromosomal locations of alpha1-5, identification of heterotrimeric laminins 8-11, and cloning of a novel alpha3 isoform.

LAMA4 LAMA5

6.07e-05142929151674
Pubmed

Platr4 is an early embryonic lncRNA that exerts its function downstream on cardiogenic mesodermal lineage commitment.

LAMA4 LAMA5

6.07e-051429236347239
Pubmed

Basement membrane composition in the early mouse embryo day 7.

LAMA4 LAMA5

7.00e-051529215895400
Pubmed

Defective glomerulogenesis in the absence of laminin alpha5 demonstrates a developmental role for the kidney glomerular basement membrane.

LAMA4 LAMA5

7.00e-051529210625553
Pubmed

Laminin alpha5 chain is required for intestinal smooth muscle development.

LAMA4 LAMA5

7.00e-051529212921739
Pubmed

Cell-matrix signals specify bone endothelial cells during developmental osteogenesis.

LAMA4 LAMA5

8.00e-051629228218908
Pubmed

Laminin alpha5 is necessary for submandibular gland epithelial morphogenesis and influences FGFR expression through beta1 integrin signaling.

LAMA4 LAMA5

8.00e-051629217601529
Pubmed

Myocardial-specific R-spondin3 drives proliferation of the coronary stems primarily through the Leucine Rich Repeat G Protein coupled receptor LGR4.

LGR6 AXIN2

8.00e-051629229859889
Pubmed

Laminin-511 and integrin beta-1 in hair follicle development and basal cell carcinoma formation.

LAMA5 ADCY3

8.00e-051629221067603
Pubmed

Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins.

SELP IGF1R LRP1B

8.22e-0510129323382219
Pubmed

Laminin α1 is essential for mouse cerebellar development.

LAMA4 LAMA5

9.06e-051729221983115
Pubmed

LGR4 and LGR5 Regulate Hair Cell Differentiation in the Sensory Epithelium of the Developing Mouse Cochlea.

LGR6 AXIN2

9.06e-051729227559308
Pubmed

Beta1-integrins are critical for cerebellar granule cell precursor proliferation.

LAMA4 LAMA5

9.06e-051729215056720
Pubmed

Marker genes identify three somatic cell types in the fetal mouse ovary.

LGR6 AXIN2

9.06e-051729225158167
Pubmed

Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

LAMA5 SSPOP ADCY3

9.23e-051052939628581
Pubmed

Mucin gene expression in human laryngeal epithelia: effect of laryngopharyngeal reflux.

MUC19 MUC5AC

1.02e-041829218834073
Pubmed

Novel susceptibility loci for second primary tumors/recurrence in head and neck cancer patients: large-scale evaluation of genetic variants.

IGF1R AXIN2

1.02e-041829219584075
Pubmed

Amplification of extracellular matrix and oncogenes in tat-transfected human salivary gland cell lines with expression of laminin, fibronectin, collagens I, III, IV, c-myc and p53.

LAMA4 LAMA5

1.02e-041829211311202
Pubmed

Primary cilia maintain corneal epithelial homeostasis by regulation of the Notch signaling pathway.

MUC5AC AXIN2

1.14e-041929227122169
Pubmed

The hippo pathway effector Yap controls patterning and differentiation of airway epithelial progenitors.

MUC5AC AXIN2

1.14e-041929225043473
Pubmed

Independent functions and mechanisms for homeobox gene Barx1 in patterning mouse stomach and spleen.

MUC5AC AXIN2

1.14e-041929217855428
Pubmed

Laminin and integrin expression in the ventral ectodermal ridge of the mouse embryo: implications for regulation of BMP signalling.

LAMA4 LAMA5

1.26e-042029222911573
Pubmed

Schwann cell myelination requires integration of laminin activities.

LAMA4 LAMA5

1.40e-042129222767514
Pubmed

Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo.

NFXL1 LAMA5 PLPP5 ZNF296

1.50e-0432629417015433
Pubmed

Aberrant androgen action in prostatic progenitor cells induces oncogenesis and tumor development through IGF1 and Wnt axes.

IGF1R AXIN2

1.53e-042229235902588
Pubmed

Zfp296 negatively regulates H3K9 methylation in embryonic development as a component of heterochromatin.

ZNF296 KDM4B

1.53e-042229228963472
Pubmed

WNT4 and RSPO1 together are required for cell proliferation in the early mouse gonad.

IGF1R AXIN2

1.53e-042229223095882
Pubmed

The role of Irf6 in tooth epithelial invagination.

JAG2 AXIN2

1.53e-042229222366192
Pubmed

Functional roles of Lgr4 and Lgr5 in embryonic gut, kidney and skin development in mice.

LGR6 AXIN2

1.68e-042329224680895
Pubmed

Neonatal Wnt-dependent Lgr5 positive stem cells are essential for uterine gland development.

LGR6 AXIN2

1.83e-042429231772170
Pubmed

Fgfr2 is required for the expansion of the early adrenocortical primordium.

IGF1R AXIN2

1.83e-042429226141512
Pubmed

Conditional deletion of beta1-integrin in astroglia causes partial reactive gliosis.

LAMA4 LAMA5

1.99e-042529219373938
Pubmed

Cannabinoid inhibits HIV-1 Tat-stimulated adhesion of human monocyte-like cells to extracellular matrix proteins.

LAMA4 LAMA5

2.15e-042629224742657
Pubmed

Signalling codes for the maintenance and lineage commitment of embryonic gastric epithelial progenitors.

MUC5AC AXIN2

2.33e-042729232878924
Pubmed

The E3 ubiquitin ligase Siah1 regulates adrenal gland organization and aldosterone secretion.

SCNN1A AXIN2

2.50e-042829229212953
Pubmed

R-spondin signalling is essential for the maintenance and differentiation of mouse nephron progenitors.

LGR6 AXIN2

2.88e-043029232324134
Pubmed

E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.

DNAH2 MUC19 SSPOP CNOT1 P3H1

3.26e-0473629529676528
Pubmed

The role of primary cilia in corpus callosum formation is mediated by production of the Gli3 repressor.

ADCY3 AXIN2

3.49e-043329226071364
Pubmed

The loss of Hoxa5 function promotes Notch-dependent goblet cell metaplasia in lung airways.

JAG2 MUC5AC

3.49e-043329223213461
Pubmed

Activation of beta-catenin signaling programs embryonic epidermis to hair follicle fate.

LAMA5 AXIN2

3.49e-043329218480165
Pubmed

The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices.

LAMA4 LAMA5 LPA

3.62e-0416729322159717
Pubmed

Gfi1b regulates the level of Wnt/β-catenin signaling in hematopoietic stem cells and megakaryocytes.

KDM4B AXIN2

3.70e-043429230894540
Pubmed

Negative regulation of Shh levels by Kras and Fgfr2 during hair follicle development.

JAG2 AXIN2

3.70e-043429223123965
Cytoband1p34.1

KLF17 P3H1

6.02e-04572921p34.1
GeneFamilyLaminin subunits

LAMA4 LAMA5

7.62e-0512202626
GeneFamilyCD molecules|Mucins

MUC19 MUC5AC

2.41e-0421202648
CoexpressionNABA_MATRISOME

MUC19 LAMA4 LAMA5 SSPOP MUC5AC CRISPLD1 P3H1 LPA FAM20B

6.34e-071008289MM17056
CoexpressionNABA_MATRISOME

MUC19 LAMA4 LAMA5 SSPOP MUC5AC CRISPLD1 P3H1 LPA FAM20B

7.35e-071026289M5889
CoexpressionNABA_ECM_GLYCOPROTEINS

LAMA4 LAMA5 SSPOP CRISPLD1

4.88e-05191284MM17059
CoexpressionGSE21927_UNTREATED_VS_GMCSF_GCSF_TREATED_BONE_MARROW_UP

JAG2 CRISPLD1 ADCY3 AXIN2

5.39e-05196284M7588
CoexpressionNABA_ECM_GLYCOPROTEINS

LAMA4 LAMA5 SSPOP CRISPLD1

5.39e-05196284M3008
CoexpressionFOROUTAN_PRODRANK_TGFB_EMT_DN

SCNN1A JAG2 LAMA5

9.14e-0582283M42504
CoexpressionKIM_GASTRIC_CANCER_CHEMOSENSITIVITY

SCNN1A ADCY3 KDM4B

1.41e-0495283M14702
CoexpressionNABA_CORE_MATRISOME

LAMA4 LAMA5 SSPOP CRISPLD1

1.86e-04270284MM17057
CoexpressionWOO_LIVER_CANCER_RECURRENCE_UP

JAG2 LAMA4 LAMA5

1.90e-04105283M12602
CoexpressionNABA_CORE_MATRISOME

LAMA4 LAMA5 SSPOP CRISPLD1

1.99e-04275284M5884
CoexpressionFOROUTAN_TGFB_EMT_DN

SCNN1A JAG2 LAMA5

2.07e-04108283M42502
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Myeloid-Dendritic-plasmacytoid_dendritic_cell-DC_c4-LILRA4|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

JAG2 MUC19 LAMA5 OR2T11 SSPOP

3.38e-08143295d0ed8c25da1327085e042c2e03cb7503e2c52ce0
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Myeloid-Dendritic-plasmacytoid_dendritic_cell|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

JAG2 MUC19 LAMA5 OR2T11 SSPOP

3.38e-081432958900b92a24289204b9ec7baccc11594fec7694f1
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

SCNN1A MUC19 LAMA5 IGF1R

3.33e-061592948680b054622f573a82b1625fb93c2d5db81d1034
ToppCellLPS-IL1RA+antiTNF-Epithelial_alveolar-Mes-Like-Differentiating_AT1|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DNAH2 SCNN1A ZFHX2

4.70e-05108293d620f07243c2628494e689bbfabc14c453f4b1f4
ToppCellTCGA-Brain-Primary_Tumor-Low_Grade_Glioma-Oligodendroglioma-10|TCGA-Brain / Sample_Type by Project: Shred V9

SCNN1A LGR6 OR2T11

4.96e-05110293518b21e5af2db1c8bfe7acf3cfff502897053ca8
ToppCellCOVID-19-kidney-Epithelial_(EC)|COVID-19 / Disease (COVID-19 only), tissue and cell type

MUC19 LRP1B KRTAP21-2

8.72e-05133293a8abb6b54862123961ae6defbf251ee6e9575258
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-24m-Macroglial|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SSPOP LRP1B GEN1

9.73e-05138293c1a46fbf1beffa12c3d1b78361e0613e2e9e2d13
ToppCellremission-multiplets|remission / disease stage, cell group and cell class

JAG2 SELP LGR6

1.22e-04149293e9974260a5f2999b363f306cae005698c912893a
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-24m-Macroglial-oligodendrocyte|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SSPOP LRP1B GEN1

1.25e-04150293afd651c654e715414eff64cf3a37378d057a56a2
ToppCellChildren_(3_yrs)-Epithelial-basal_cell-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

LAMA5 LRP1B LPA

1.45e-04158293d78e7e52657dc094430291fec07e9c298be9e584
ToppCelldroplet-Lung-immune-endo-depleted-3m-Lymphocytic-Zbtb32+_B|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NFXL1 PLPP5 ZNF296

1.53e-04161293249c2b97cc25de5053f5048ee354615df49b2081
ToppCelldroplet-Heart-nan-24m-Mesenchymal-coronary_vascular_endothelial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

JAG2 SELP LGR6

1.71e-04167293a35ace2c722936d2a3e1f0826e5b6ec6b1340d2b
ToppCell356C-Myeloid-Dendritic-cDC_proliferating_2|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

JAG2 LAMA4 GEN1

1.83e-04171293b113fbebb89056af0b9c775d2fb6552206a80467
ToppCellFetal_29-31_weeks-Endothelial-endothelial_cell_of_artery-D062|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

JAG2 SELP MUC19

1.86e-04172293de9b11ab109d04937186c09772cec9105a935f95
ToppCellfacs-Lung-24m-Mesenchymal-myofibroblast|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SELP CRISPLD1 ADCY3

1.93e-04174293a7ade7372e83edd4e3983e77f8417b51f0b47340
ToppCellPBMC-Severe-Lymphocyte-B-B_cell-B_memory-B_memory-6|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

PLPP5 ZNF296 GEN1

1.96e-04175293eaec7fda07a9537d067ca13b607a8ab201caa7c4
ToppCell356C-Myeloid-Dendritic-cDC_proliferating_2|Dendritic / Donor, Lineage, Cell class and subclass (all cells)

JAG2 LAMA4 GEN1

1.96e-041752937de1023161233b64f11e130881c742f4cf2bff65
ToppCellwk_20-22-Endothelial-Blood_vessel_endothelial-OMD+_endo|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

JAG2 SELP CRISPLD1

2.00e-0417629352af8f717dbd3b59eeb868b8b7b256a8f3e57d7a
ToppCellFetal_29-31_weeks-Endothelial-endothelial_cell_of_artery|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

JAG2 SELP MUC19

2.03e-041772935ff8dcfb030312126695d53a026d2e104a401b83
ToppCellcellseq2-Mesenchymal-Fibroblastic-Fibroblastic_2-ASMC|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

LAMA4 LGR6 LRP1B

2.06e-041782938ec2a25dda96c9cc9c2904b6cb18f75a293f4969
ToppCellcellseq2-Mesenchymal-Fibroblastic-Fibroblastic_2|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

LAMA4 LGR6 LRP1B

2.06e-041782936c91331196696e0cf239d105f458e3230659fa38
ToppCelldroplet-Marrow-BM-30m-Lymphocytic-naive_T_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PLPP5 ADCY3 P3H1

2.20e-041822938b16a13d8606d21a7a9ce1175237e9b4cf832ee0
ToppCelldroplet-Bladder-nan-24m-Endothelial-nan|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DNAH2 SELP CRISPLD1

2.31e-0418529390caab8d9361a541c5d5121c97c3f1cdffeeae4a
ToppCelldroplet-Marrow-nan-21m-Lymphocytic-naive_T_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SCNN1A PLPP5 P3H1

2.35e-04186293744bf39af2fb5a7454477174d7755a6d78cd279f
ToppCell343B-Fibroblasts-Fibroblast-E|343B / Donor, Lineage, Cell class and subclass (all cells)

ADCY3 P3H1 AXIN2

2.35e-0418629359db239f1864a5d4f1570c93219dbd7ac5b6db35
ToppCelldroplet-Liver-Hepatocytes-24m-Endothelial-endothelial_cell_of_hepatic_sinusoid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SELP LAMA4 IGF1R

2.35e-0418629390d53c2597a9f3a2b39afba75adfc54f1ca0a4db
ToppCell343B-Fibroblasts-Fibroblast-E-|343B / Donor, Lineage, Cell class and subclass (all cells)

ADCY3 P3H1 AXIN2

2.35e-041862931bac7825c2fe3e6cdff65026b09b9ccaa40fa27f
ToppCellmild-unassigned|mild / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

NFXL1 LGR6 ADCY3

2.35e-041862935b2e1a58916f392fa1156bf9210df528775248ff
ToppCelldroplet-Liver-Hepatocytes-24m-Endothelial|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SELP LAMA4 IGF1R

2.35e-041862932cae34336f184f971f7c8684cc27c23a4e7369ed
ToppCellSmart-seq2-blood_(Smart-seq2)-myeloid-myeloid_monocytic-classical_monocyte|blood_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

MUC19 NFXL1 LRP1B

2.35e-0418629323b8d51d20b05795a73892d3e20e0f9b6a207820
ToppCell5'-Adult-LymphNode-Endothelial-blood_vessel_EC|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

JAG2 SELP LAMA5

2.50e-04190293141266bf411ea675fbf889b20c1b08673c45ff95
ToppCellfacs-Lung-3m-Mesenchymal-myofibroblast|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

LAMA4 LGR6 AXIN2

2.54e-04191293fd8331c7abdd999f55ba43d307945c6abfccbf84
ToppCellBasal_cells-IPF_02|World / lung cells shred on cell class, cell subclass, sample id

JAG2 LAMA5 LGR6

2.54e-04191293a98915bad9a4a61dd4cbca798914849b805f4a19
ToppCell10x5'v1-week_12-13-Endothelial-stroma-tip_EC|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

JAG2 LAMA4 LAMA5

2.54e-04191293cf1a67b7c0d5c0dc5d4d59faf9d9b1a3a1fb00e0
ToppCellhealthy_donor-Lymphocytic-B_cell|healthy_donor / Disease condition, Lineage, Cell class and subclass

LAMA5 PLPP5 GEN1

2.58e-041922937d9e5772b6e531b50ed4e4d6304ef11235f27f37
ToppCellhealthy_donor-Lymphocytic-B_cell-|healthy_donor / Disease condition, Lineage, Cell class and subclass

LAMA5 PLPP5 GEN1

2.58e-04192293975312f9d6cede4d4f5b737e481e5c73accc8c50
ToppCellfacs-Lung-3m-Mesenchymal-myofibroblast-myofibroblast_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

LAMA4 LGR6 AXIN2

2.70e-04195293c6bb16c0076639c6ddef1a15d8cba44bc29c077d
ToppCellfacs-Lung-3m-Mesenchymal-myofibroblast-myofibroblast_cell-pulmonary_interstitial_myofibroblast|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

LAMA4 LGR6 AXIN2

2.70e-04195293ea89f80d3d7e9f737442f7c1aa1791d277ffc90c
ToppCellBAL-Mild-Epithelial-Epithelial-Basal/Club-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

SCNN1A MUC5AC AXIN2

2.74e-0419629391a3c3091064f1f5a3bdc1dd5883fc24dce8ff05
ToppCellBAL-Mild-Epithelial-Epithelial-Basal/Club|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

SCNN1A MUC5AC AXIN2

2.74e-04196293e819088a74d29e958371aa851ac9c74ec55367b7
ToppCellBAL-Mild-Epithelial-Epithelial-Basal/Club|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)

SCNN1A MUC5AC AXIN2

2.74e-04196293e675d661b6494ac3a85ba7ee5bdeaa98b8bbe957
ToppCellBronchial-NucSeq-Stromal-Myofibroblastic-Muscle_smooth_airway_ASM|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

LAMA4 LGR6 LRP1B

2.74e-041962939830fb3da7a60f65ad463e9054bb77c06b025e4d
ToppCellBAL-Mild-Epithelial-Epithelial-Basal/Club-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

SCNN1A MUC5AC AXIN2

2.74e-04196293a4d05d85fbafa869df19bba3881020ea433d81fb
ToppCellTracheal-NucSeq-Epithelial-Epi_submucosal-gland-Myoepithelial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

JAG2 LGR6 CRISPLD1

2.78e-04197293f0475ad9c09c6da418dba17d3d3c1aaa2ef9ab4e
ToppCellParenchyma_Control_(B.)-Endothelial-TX-Endothelial-1|Parenchyma_Control_(B.) / Sample group, Lineage and Cell type

JAG2 SELP LAMA5

2.78e-04197293f969685dee212f33a6f09e54c0cd1fd24ffef546
ToppCellBasal_cells|World / lung cells shred on cell class, cell subclass, sample id

JAG2 LAMA5 LGR6

2.78e-0419729324360b660000bdfb999d58fbf4e29585a97e1785
ToppCellMild_COVID-19-Epithelial-Basal/Club|Mild_COVID-19 / Disease group,lineage and cell class （2021.01.30）

SCNN1A MUC5AC AXIN2

2.78e-041972934cc5b778e1e2c6c149160fa147c172977c0fa8eb
ToppCellLung_Parenchyma-Control-Endothelial-Endothelial-Endothelial-1-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

JAG2 SELP LAMA5

2.78e-0419729396d63a8d00583e2aa0a38412e2ae27e23f399493
ToppCellLung_Parenchyma-Control-Endothelial-Endothelial-Endothelial-1|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

JAG2 SELP LAMA5

2.78e-041972931a137af40697137bb9d2b5caf2b1ffda55f04461
ToppCellParenchymal-NucSeq-Epithelial-Epi_airway_secretory|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

SCNN1A IGF1R MUC5AC

2.82e-04198293af399569c718f5fd971d73a7926768c9311002a3
ToppCellTracheal-NucSeq-Stromal-Myofibroblastic-Muscle_smooth_airway_ASM|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

LAMA4 LGR6 LRP1B

2.82e-0419829322e766df1276c5b14aa0d83f434f47140ebb98ea
ToppCellTracheal-NucSeq-Epithelial-Epi_airway_basal|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

JAG2 LAMA5 LGR6

2.82e-041982935374b0e98d669f36a0571d3c006c7bd5e3c8e87f
ToppCellTracheal-NucSeq-Epithelial-Epi_airway_basal-Basal|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

JAG2 LAMA5 LGR6

2.86e-0419929394a7867e800df352731796de8c24cba133c29622
ToppCell5'-Adult-LargeIntestine-Endothelial-blood_vessel_EC|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

JAG2 SELP LAMA5

2.86e-04199293258d59cf811bf1668ffbb5f18f961021f660de62
ToppCell5'-Adult-SmallIntestine-Endothelial-blood_vessel_EC|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

JAG2 SELP LAMA5

2.90e-04200293cd3c638961144a2fc91c437a173cc37c7452fa74
ToppCellcontrol|World / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

SCNN1A LAMA5 IGF1R

2.90e-0420029397f36d2c197e03d93a1fc59949d77ae90f6e6a9a
DrugCerebro

LAMA4 LAMA5 LPA

5.96e-0628293CID000005354
DiseaseSjogren's syndrome (is_marker_for)

SELP MUC19 MUC5AC

1.53e-0624283DOID:12894 (is_marker_for)
Diseasegallbladder cancer (is_implicated_in)

LRP1B AXIN2

6.73e-0513282DOID:3121 (is_implicated_in)
Diseasecolorectal cancer (is_implicated_in)

LRP1B KDM4B AXIN2

2.04e-04121283DOID:9256 (is_implicated_in)
Diseaseage at menarche

DNAH2 IGF1R LRP1B ADCY3 KDM4B

2.18e-04594285EFO_0004703
Diseasecolon carcinoma

ODF1 CRISPLD1

2.78e-0426282EFO_1001950
Diseaseulcerative colitis (is_marker_for)

SELP IGF1R

6.62e-0440282DOID:8577 (is_marker_for)
Diseaselung adenocarcinoma (is_implicated_in)

LRP1B AXIN2

9.93e-0449282DOID:3910 (is_implicated_in)
Diseaseadverse effect, response to xenobiotic stimulus

SCNN1A LRP1B

1.44e-0359282EFO_0009658, GO_0009410
Diseasepancreatic ductal carcinoma (is_marker_for)

IGF1R MUC5AC

1.53e-0361282DOID:3587 (is_marker_for)
Diseasepulse pressure measurement

LAMA5 ODF1 SSPOP CRISPLD1 CNOT1 KDM4B

1.68e-031392286EFO_0005763
DiseaseAlzheimer's disease (is_marker_for)

SELP IGF1R LPA

1.82e-03257283DOID:10652 (is_marker_for)
Diseasestomach cancer (is_implicated_in)

LRP1B KDM4B

2.13e-0372282DOID:10534 (is_implicated_in)
Diseaselung cancer (is_implicated_in)

LRP1B AXIN2

2.25e-0374282DOID:1324 (is_implicated_in)
DiseaseLung diseases

SCNN1A IGF1R

2.49e-0378282C0024115

Protein segments in the cluster

PeptideGeneStartEntry
CFCPGGSEYYCYSKC

AXIN2

541

Q9Y2T1
ECRALCEGPYDYDGY

P3H1

241

Q32P28
CQPEYTGDRCQYYVC

LRP1B

4311

Q9NZR2
RYYCYCGKVEDPPLD

NFXL1

231

Q6ZNB6
LEVPYAYQCCPYGMC

LGR6

471

Q9HBX8
CYNLEGDYYCACPDD

JAG2

551

Q9Y219
CRHYYYAGVCVPACP

IGF1R

251

P08069
CPVYCDYYNAPGECR

MUC19

1536

Q7Z5P9
EPYCAICTLFYPYCQ

KDM4B

681

O94953
CPLFCDYYNPEGQCE

MUC5AC

1161

P98088
RCDTCVPGAYNFPYC

LAMA5

706

O15230
MHPYCCCDLHPYPYC

ODF1

41

Q14990
CCDLHPYPYCLCYSK

ODF1

46

Q14990
YPYEHECNPYCPFRC

CRISPLD1

146

Q9H336
LGDCYYCICGLPDYR

ADCY3

366

O60266
YCRNPDAVAAPYCYT

LPA

76

P08519
NYCRNPDAVAAPYCY

LPA

531

P08519
YCRNPDAVAAPYCYT

LPA

646

P08519
YTCSCYPGFYGPECE

SELP

181

P16109
YPGFYGPECEYVREC

SELP

186

P16109
YCEPHDYEYCCPCEW

GEN1

286

Q17RS7
RPYCCNYENCGKAYT

KLF17

281

Q5JT82
CGYSSSCCGYRPLCY

KRTAP21-2

61

Q3LI59
CPCYYYPNRAGSSDR

DNAH2

4381

Q9P225
CAYIFYPRPQNVEYC

SCNN1A

431

P37088
AYDCYVAVCNPLRYP

OR2T11

116

Q8NH01
YAGPNCERCAPGYYG

LAMA4

161

Q16363
PAAHCPCYYCRQRYV

SSPOP

521

A2VEC9
CDYHYGFCDVIPPNC

CNOT1

2111

A5YKK6
YNCGYKPYRCDVCNY

ZFHX2

501

Q9C0A1
CFYGKCYYCRETEPA

FAM20B

196

O75063
VCYRQYYPPLTDAEC

PLPP5

226

Q8NEB5
ERPYACDQCPYACAQ

ZNF296

256

Q8WUU4