Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctiontranscription coactivator activity

NCOA6 ABL1 NACA SRCAP TRIP11 TSC22D1 CCAR1 MYOCD MED17 TAF12 MED13 MRTFA

4.82e-0630315612GO:0003713
GeneOntologyMolecularFunctiontranscription factor binding

BDP1 SP1 NCOA6 SP3 NACA NR4A1 RUNX2 RUNX1 CREB1 PYHIN1 NCOR1 MYOCD TAF4 MED17 TAF12 NFAT5 LRIF1 MED13

2.51e-0575315618GO:0008134
GeneOntologyMolecularFunctiontranscription coregulator activity

NCOA6 ABL1 NACA GON4L MED13L SRCAP TRIP11 NCOR1 TSC22D1 CCAR1 MYOCD MED17 TAF12 MED13 MRTFA

3.58e-0556215615GO:0003712
GeneOntologyMolecularFunctionglucan 1,4-alpha-glucosidase activity

MGAM MGAM2

6.06e-0521562GO:0004339
GeneOntologyMolecularFunctionhistone acetyltransferase binding

SP1 CREB1 EGR1 MYOCD

7.31e-05291564GO:0035035
GeneOntologyMolecularFunctionnuclear thyroid hormone receptor binding

NCOA6 NCOR1 MED17 MED13

1.38e-04341564GO:0046966
GeneOntologyMolecularFunctionDNA-binding transcription factor binding

SP1 NCOA6 SP3 NR4A1 RUNX2 RUNX1 CREB1 NCOR1 MYOCD TAF4 MED17 TAF12 LRIF1 MED13

1.95e-0458215614GO:0140297
GeneOntologyMolecularFunctionnuclear vitamin D receptor binding

NCOA6 MED17 MED13

3.50e-04181563GO:0042809
GeneOntologyMolecularFunctionRNA polymerase II-specific DNA-binding transcription factor binding

SP1 NCOA6 SP3 NR4A1 CREB1 NCOR1 MYOCD TAF4 MED17 LRIF1 MED13

4.48e-0441715611GO:0061629
GeneOntologyMolecularFunctionalpha-1,4-glucosidase activity

MGAM MGAM2

5.97e-0451562GO:0004558
GeneOntologyMolecularFunctioncore promoter sequence-specific DNA binding

POU2F1 RFX7 EGR1 TAF4

8.97e-04551564GO:0001046
GeneOntologyMolecularFunctionstructural constituent of nuclear pore

POM121 NPAP1 POM121B

9.48e-04251563GO:0017056
GeneOntologyMolecularFunctionRNA polymerase II core promoter sequence-specific DNA binding

POU2F1 RFX7 EGR1

9.48e-04251563GO:0000979
GeneOntologyMolecularFunctionnuclear localization sequence binding

POM121 NPAP1 POM121B

1.19e-03271563GO:0008139
GeneOntologyMolecularFunctionalpha-glucosidase activity

MGAM MGAM2

1.24e-0371562GO:0090599
GeneOntologyMolecularFunctionnuclear receptor coactivator activity

NCOA6 CCAR1 MED17 MED13

1.32e-03611564GO:0030374
GeneOntologyMolecularFunctionHsp70 protein binding

CREB1 NOD2 DNAJC10 TSACC

1.49e-03631564GO:0030544
GeneOntologyMolecularFunctionDNA-binding transcription activator activity, RNA polymerase II-specific

SP1 SOX30 POU2F1 NR4A1 RUNX2 RUNX1 CREB1 USF3 HOXC11 EGR1 NFAT5 MYB

1.52e-0356015612GO:0001228
GeneOntologyMolecularFunctiongeneral transcription initiation factor binding

BDP1 NACA RUNX2 TAF12

1.58e-03641564GO:0140296
GeneOntologyMolecularFunctionDNA-binding transcription activator activity

SP1 SOX30 POU2F1 NR4A1 RUNX2 RUNX1 CREB1 USF3 HOXC11 EGR1 NFAT5 MYB

1.67e-0356615612GO:0001216
GeneOntologyMolecularFunctionRNA polymerase II transcription regulatory region sequence-specific DNA binding

SP1 SP3 ZBTB38 ZBTB20 ZNF180 SOX30 SREBF2 ZBTB9 POU2F1 NR4A1 RUNX2 RUNX1 RFX7 CREB1 NCOR1 USF3 HOXC11 ZFHX4 EGR1 CCAR1 NFAT5 MYB

2.22e-03145915622GO:0000977
GeneOntologyMolecularFunctioncytoskeletal protein binding

ESPN TMEM67 ABL1 SPATA31A3 ANK2 SPATA31A7 TTLL5 CAMSAP3 LMTK2 CCDC187 RABGAP1 SPATA31A5 NOD2 SPATA31A1 AP1G1 TTLL4 MACF1 MRTFA

2.38e-03109915618GO:0008092
GeneOntologyMolecularFunctionprotein-glutamic acid ligase activity

TTLL5 TTLL4

2.62e-03101562GO:0070739
GeneOntologyMolecularFunctiontubulin-glutamic acid ligase activity

TTLL5 TTLL4

2.62e-03101562GO:0070740
GeneOntologyBiologicalProcessregulation of miRNA metabolic process

RC3H2 SREBF2 POU2F1 NCOR1 EGR1 MYOCD GNL3 MRTFA MYB

9.29e-081031579GO:2000628
GeneOntologyBiologicalProcesspositive regulation of transcription by RNA polymerase II

HEXB SP1 NCOA6 SP3 ZBTB38 ABL1 SOX30 NACA SREBF2 POU2F1 NR4A1 RUNX2 RUNX1 RFX7 AP3B1 CREB1 NOD2 TSC22D1 USF3 HOXC11 EGR1 PKD1 MYOCD TAF4 MED17 TAF12 NFAT5 MED13 MRTFA MYB

1.84e-07139015730GO:0045944
GeneOntologyBiologicalProcessregulation of miRNA transcription

SREBF2 POU2F1 NCOR1 EGR1 MYOCD GNL3 MRTFA MYB

2.29e-07831578GO:1902893
GeneOntologyBiologicalProcessmiRNA transcription

SREBF2 POU2F1 NCOR1 EGR1 MYOCD GNL3 MRTFA MYB

2.52e-07841578GO:0061614
GeneOntologyBiologicalProcessmiRNA metabolic process

RC3H2 SREBF2 POU2F1 NCOR1 EGR1 MYOCD GNL3 MRTFA MYB

3.23e-071191579GO:0010586
GeneOntologyBiologicalProcesspositive regulation of miRNA transcription

SREBF2 POU2F1 EGR1 MYOCD GNL3 MRTFA MYB

4.00e-07611577GO:1902895
GeneOntologyBiologicalProcesspositive regulation of miRNA metabolic process

SREBF2 POU2F1 EGR1 MYOCD GNL3 MRTFA MYB

1.38e-06731577GO:2000630
GeneOntologyBiologicalProcesssecretory granule organization

SOX30 KIAA0319L AP3B1 CREB1 LYST AP1B1 AP1G1

2.17e-06781577GO:0033363
GeneOntologyBiologicalProcesshematopoietic progenitor cell differentiation

SP1 SP3 ABL1 RUNX1 AP3B1 BRAF PTPRZ1 MUC4 YTHDF2 MYB

2.79e-0619715710GO:0002244
GeneOntologyBiologicalProcessmyeloid progenitor cell differentiation

SP1 SP3 RUNX1 BRAF

3.05e-06141574GO:0002318
GeneOntologyBiologicalProcessDNA-templated transcription initiation

BDP1 NCOA6 ATAD2 CREB1 EGR1 MYOCD TAF4 MED17 TAF12 MED13

1.14e-0523115710GO:0006352
GeneOntologyBiologicalProcessmRNA transcription by RNA polymerase II

SP1 AP3B1 CREB1 TAF4 TAF12

4.67e-05521575GO:0042789
GeneOntologyBiologicalProcessdefinitive hemopoiesis

SP1 SP3 RUNX1 NCOR1

4.95e-05271574GO:0060216
GeneOntologyBiologicalProcessproacrosomal vesicle fusion

SOX30 KIAA0319L

5.76e-0521572GO:0120211
GeneOntologyBiologicalProcessmRNA transcription

SP1 AP3B1 CREB1 TAF4 TAF12

7.29e-05571575GO:0009299
GeneOntologyBiologicalProcessregulation of cell adhesion

RC3H2 ABL1 PIEZO1 CD164 CAMSAP3 MDGA2 RUNX1 AP3B1 NOD2 PTPRA BRAF PTPRZ1 PKD1 TMEM131L MACF1 PLD2 NFAT5 MUC4 YTHDF2

8.33e-0592715719GO:0030155
GeneOntologyBiologicalProcesstranscription initiation at RNA polymerase II promoter

ATAD2 CREB1 EGR1 MYOCD TAF4 MED17 TAF12 MED13

9.16e-051861578GO:0006367
GeneOntologyBiologicalProcessT cell differentiation

RC3H2 SP3 ABL1 RUNX2 RUNX1 AP3B1 NCOR1 BRAF EGR1 TMEM131L MYB

1.71e-0438215711GO:0030217
GeneOntologyBiologicalProcesspositive regulation of transcription initiation by RNA polymerase II

CREB1 TAF4 MED17 TAF12 MED13

1.95e-04701575GO:0060261
GeneOntologyBiologicalProcessalpha-beta T cell differentiation

RC3H2 ABL1 RUNX1 AP3B1 NCOR1 BRAF MYB

2.03e-041571577GO:0046632
GeneOntologyBiologicalProcessmelanosome organization

AP3B1 LYST AP1B1 AP1G1

2.16e-04391574GO:0032438
GeneOntologyBiologicalProcesspigment granule organization

AP3B1 LYST AP1B1 AP1G1

2.39e-04401574GO:0048753
GeneOntologyBiologicalProcesspositive regulation of DNA-templated transcription initiation

CREB1 TAF4 MED17 TAF12 MED13

3.05e-04771575GO:2000144
GeneOntologyBiologicalProcesscondensed mesenchymal cell proliferation

DCHS2 FAT4

3.42e-0441572GO:0072137
GeneOntologyBiologicalProcessmelanosome assembly

AP3B1 AP1B1 AP1G1

3.83e-04191573GO:1903232
GeneOntologyBiologicalProcessregulation of transcription initiation by RNA polymerase II

CREB1 TAF4 MED17 TAF12 MED13

3.85e-04811575GO:0060260
GeneOntologyBiologicalProcesshemopoiesis

SP1 NCOA6 RC3H2 SP3 PRTN3 ABL1 CD164 GON4L RUNX2 RUNX1 AP3B1 CREB1 NCOR1 TSC22D1 BRAF EGR1 PTPRZ1 TMEM131L MUC4 YTHDF2 MYB

4.00e-04122315721GO:0030097
GeneOntologyCellularComponenttranscription regulator complex

BDP1 SP1 NCOA6 SP3 POU2F1 NR4A1 RUNX2 RUNX1 CREB1 NCOR1 MYOCD TAF4 MED17 TAF12 NFAT5 MYB

1.22e-0559615816GO:0005667
MousePhenopericardial effusion

NCOA6 PIEZO1 RTTN NACA RUNX1 BRAF PKD1 MYOCD MGRN1

6.00e-071111249MP:0005312
MousePhenoeffusion

NCOA6 PIEZO1 RTTN NACA RUNX1 BRAF PKD1 MYOCD MGRN1

8.21e-061521249MP:0021205
MousePhenoincreased nucleated erythrocyte cell number

DPH1 RUNX2 RUNX1 NCOR1 MYB

5.77e-05471245MP:0009395
MousePhenoabnormal nucleated erythrocyte cell number

DPH1 RUNX2 RUNX1 NCOR1 MYB

7.07e-05491245MP:0012397
DomainTMEM131-like

TMEM131L TMEM131

6.49e-0521512IPR022113
DomainMed13_N

MED13L MED13

6.49e-0521512PF11597
DomainMediator_Med13_N_met/fun

MED13L MED13

6.49e-0521512IPR021643
DomainTMEM131_like

TMEM131L TMEM131

6.49e-0521512PF12371
DomainMed13_C

MED13L MED13

6.49e-0521512PF06333
DomainMediator_Med13

MED13L MED13

6.49e-0521512IPR009401
DomainDUF4599

SPATA31A3 SPATA31A7 SPATA31A5

1.08e-04121513PF15371
DomainDUF4599

SPATA31A3 SPATA31A7 SPATA31A5

1.08e-04121513IPR027970
DomainRunt

RUNX2 RUNX1

1.94e-0431512PF00853
DomainRUNT

RUNX2 RUNX1

1.94e-0431512PS51062
DomainTF_Runt-rel_RUNX

RUNX2 RUNX1

1.94e-0431512IPR016554
DomainRunxI

RUNX2 RUNX1

1.94e-0431512PF08504
DomainRunt_dom

RUNX2 RUNX1

1.94e-0431512IPR013524
DomainRunxI_C_dom

RUNX2 RUNX1

1.94e-0431512IPR013711
DomainRunx_central_dom

RUNX2 RUNX1

1.94e-0431512IPR027384
Domain-

RUNX2 RUNX1

1.94e-04315124.10.770.10
DomainAML1_Runt

RUNX2 RUNX1

1.94e-0431512IPR000040
DomainClathrin/coatomer_adapt-like_N

AP3B1 AP1B1 AP1G1

2.19e-04151513IPR002553
DomainAdaptin_N

AP3B1 AP1B1 AP1G1

2.19e-04151513PF01602
DomainMYB_LIKE

BDP1 GON4L NCOR1 MYB

2.45e-04381514PS50090
DomainGal_mutarotase_N

MGAM MGAM2

3.85e-0441512IPR031727
DomainB2-adapt-app_C

AP3B1 AP1B1

3.85e-0441512SM01020
DomainB-adaptin_app_sub_C

AP3B1 AP1B1

3.85e-0441512IPR015151
DomainNtCtMGAM_N

MGAM MGAM2

3.85e-0441512PF16863
Domain-

CCAR1 MYOCD MRTFA

6.19e-042115131.10.720.30
DomainNIDO_dom

TECTA MUC4

6.39e-0451512IPR003886
DomainAP_beta

AP3B1 AP1B1

6.39e-0451512IPR026739
DomainNIDO

TECTA MUC4

6.39e-0451512SM00539
DomainNIDO

TECTA MUC4

6.39e-0451512PF06119
DomainNIDO

TECTA MUC4

6.39e-0451512PS51220
DomainSANT

BDP1 GON4L NCOR1 MYB

7.08e-04501514SM00717
DomainSAP

CCAR1 MYOCD MRTFA

7.13e-04221513PF02037
DomainSAP

CCAR1 MYOCD MRTFA

8.15e-04231513SM00513
DomainSANT/Myb

BDP1 GON4L NCOR1 MYB

8.22e-04521514IPR001005
Domainp53/RUNT-type_TF_DNA-bd

RUNX2 RUNX1

9.53e-0461512IPR012346
Domain-

RUNX2 RUNX1

9.53e-04615122.60.40.720
DomainGlyco_hydro_31_AS

MGAM MGAM2

9.53e-0461512IPR030458
DomainPKD/REJ-like

KIAA0319L PKD1

9.53e-0461512IPR002859
DomainREJ

KIAA0319L PKD1

9.53e-0461512PF02010
DomainSAP

CCAR1 MYOCD MRTFA

1.05e-03251513PS50800
DomainSAP_dom

CCAR1 MYOCD MRTFA

1.05e-03251513IPR003034
DomainGlyco_hydro_31

MGAM MGAM2

1.33e-0371512IPR000322
DomainRPEL

MYOCD MRTFA

1.33e-0371512PS51073
DomainRPEL

MYOCD MRTFA

1.33e-0371512SM00707
DomainGlyco_hydro_31

MGAM MGAM2

1.33e-0371512PF01055
DomainRPEL

MYOCD MRTFA

1.33e-0371512PF02755
DomainRPEL_repeat

MYOCD MRTFA

1.33e-0371512IPR004018
DomainGLYCOSYL_HYDROL_F31_1

MGAM MGAM2

1.33e-0371512PS00129
DomainHomeodomain-like

BDP1 GON4L POU2F1 RABGAP1 NCOR1 HOXC11 ZFHX4 DBX1 MYB

1.54e-033321519IPR009057
DomainTrefoil

MGAM MGAM2

1.76e-0381512PF00088
Domain-

GON4L POU2F1 RABGAP1 NCOR1 HOXC11 ZFHX4 DBX1 MYB

2.16e-0328315181.10.10.60
DomainAlpha_adaptinC2

AP1B1 AP1G1

2.25e-0391512PF02883
DomainP_TREFOIL_2

MGAM MGAM2

2.25e-0391512PS51448
DomainClathrin_a/b/g-adaptin_app_Ig

AP1B1 AP1G1

2.25e-0391512IPR008152
DomainPKD/Chitinase_dom

KIAA0319L PKD1

2.25e-0391512IPR022409
DomainAlpha_adaptinC2

AP1B1 AP1G1

2.25e-0391512SM00809
DomainPKD

KIAA0319L PKD1

2.25e-0391512SM00089
DomainPD

MGAM MGAM2

2.25e-0391512SM00018
DomainSp1_fam

SP1 SP3

2.80e-03101512IPR030450
DomainIGc2

NRG2 MDGA2 CNTN6 IGSF10 NPTN AMIGO3 BCAM

3.05e-032351517SM00408
DomainIg_sub2

NRG2 MDGA2 CNTN6 IGSF10 NPTN AMIGO3 BCAM

3.05e-032351517IPR003598
Domain-

MGAM MGAM2

3.40e-031115124.10.110.10
DomainPKD

KIAA0319L PKD1

3.40e-03111512PS50093
DomainPKD_dom

KIAA0319L PKD1

3.40e-03111512IPR000601
Domain-

KIAA0319L PKD1

3.40e-031115122.60.40.670
DomainP_trefoil_dom

MGAM MGAM2

4.06e-03121512IPR000519
DomainCoatomer/clathrin_app_Ig-like

AP1B1 AP1G1

4.06e-03121512IPR013041
DomainTTL

TTLL5 TTLL4

4.78e-03131512PS51221
DomainTTL/TTLL_fam

TTLL5 TTLL4

4.78e-03131512IPR004344
DomainTTL

TTLL5 TTLL4

4.78e-03131512PF03133
DomainSEA

MUC16 IMPG2

5.54e-03141512SM00200
Domain-

MUC16 IMPG2

6.36e-031515123.30.70.960
DomainVWF_type-D

TECTA MUC4

7.23e-03161512IPR001846
DomainVWFD

TECTA MUC4

7.23e-03161512PS51233
DomainVWD

TECTA MUC4

7.23e-03161512SM00216
DomainVWD

TECTA MUC4

7.23e-03161512PF00094
PathwayREACTOME_REGULATION_OF_LIPID_METABOLISM_BY_PPARALPHA

SP1 NCOA6 SREBF2 MED13L NCOR1 MED17 MED13

3.55e-051181097M27316
PathwayPID_SMAD2_3NUCLEAR_PATHWAY

SP1 SP3 RUNX2 RUNX1 CREB1 NCOR1

4.04e-05821096M2
PathwayREACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION

NCOA6 SREBF2 MED13L NCOR1 MED17 MED13

4.64e-05841096M1008
PathwayREACTOME_ADIPOGENESIS

NCOA6 SREBF2 MED13L NCOR1 MED17 MED13

2.08e-041101096M48259
PathwayREACTOME_DEFECTIVE_GALNT3_CAUSES_HFTC

MUC16 MUC4 MUC7

2.34e-04161093M27410
PathwayREACTOME_DEFECTIVE_C1GALT1C1_CAUSES_TNPS

MUC16 MUC4 MUC7

2.83e-04171093M27412
PathwayKEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_PRKACA_TO_ACTH_CORTISOL_SIGNALING_PATHWAY

SP1 NR4A1 CREB1

2.83e-04171093M47514
PathwayWP_ESTROGEN_SIGNALING

SP1 CREB1 NCOR1 BRAF TAF12

3.20e-04771095MM15934
PathwayKEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_PRKAR1A_TO_ACTH_CORTISOL_SIGNALING_PATHWAY

SP1 NR4A1 CREB1

3.37e-04181093M47516
PathwayKEGG_LYSOSOME

HEXB CD164 AP3B1 AP1B1 AP1G1 LAMP3

3.48e-041211096M11266
PathwayWP_SEROTONIN_RECEPTOR_467_AND_NR3C_SIGNALING

CREB1 BRAF EGR1

3.98e-04191093M39358
PathwayWP_MECP2_AND_ASSOCIATED_RETT_SYNDROME

SP1 SP3 CREB1 NCOR1

4.30e-04461094MM15949
PathwayKEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_PDE11A_PDE8B_TO_ACTH_CORTISOL_SIGNALING_PATHWAY

SP1 NR4A1 CREB1

4.66e-04201093M47517
PathwayREACTOME_NEF_MEDIATES_DOWN_MODULATION_OF_CELL_SURFACE_RECEPTORS_BY_RECRUITING_THEM_TO_CLATHRIN_ADAPTERS

CD8B AP1B1 AP1G1

5.40e-04211093M12347
PathwayWP_ESTRADIOL_REGULATION_IN_PORTOSINUSOIDAL_VASCULAR_DISEASE

SP1 SP3

5.83e-0451092M45554
Pubmed

A census of human transcription factors: function, expression and evolution.

SP1 RC3H2 SP3 ZBTB38 CENPT ZNF180 SOX30 SREBF2 GON4L POU2F1 NR4A1 RUNX2 RUNX1 RFX7 CREB1 TSC22D1 USF3 HOXC11 ZFHX4 EGR1 DBX1 NFAT5 MYB

3.19e-119081592319274049
Pubmed

The testis-specific VAD1.3/AEP1 interacts with β-actin and syntaxin 1 and directs peri-nuclear/Golgi expression with bipartite nucleus localization (BNL) sequence.

SPATA31A3 SPATA31A7 SPATA31A5 SPATA31A1

6.26e-096159420850414
Pubmed

Targeted disruption of the spermatid-specific gene Spata31 causes male infertility.

SPATA31A3 SPATA31A7 SPATA31A5 SPATA31A1

6.26e-096159425930072
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

NCOA6 PDE4A B4GALNT4 ABL1 PIEZO1 RTTN KIAA0319L LMTK2 PFAS REV3L MED13L SRCAP LYST NOD2 NCOR1 TTLL4 PKD1 UBE3C BCAM MBD5 GCN1 MED13

7.58e-0911051592235748872
Pubmed

An ARC/Mediator subunit required for SREBP control of cholesterol and lipid homeostasis.

SREBF2 CREB1 MED17 MED13 MYB

2.07e-0819159516799563
Pubmed

Interactome of vertebrate GAF/ThPOK reveals its diverse functions in gene regulation and DNA repair.

SP3 SREBF2 RUNX2 RUNX1 ATAD2 CREB1 HOXC11 ZFHX4 NFAT5 YTHDF2 MED13 GNL3

3.31e-083211591232098917
Pubmed

Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.

DPH1 SP1 SP3 ABCB7 SREBF2 POU2F1 PFAS MED13L ATAD2 CREB1 SLC38A2 ZNF106 UBE2R2 GTPBP2 PTPRA DBX1 NPAP1 TMEM131L ALG3 TAF4 GCN1 YTHDF2 MED13

4.30e-0813271592332694731
Pubmed

Regulation of GATA-3 expression during CD4 lineage differentiation.

NR4A1 EGR1 NFAT5 MYB

8.65e-0810159421357543
Pubmed

Sp proteins and Runx2 mediate regulation of matrix gla protein (MGP) expression by parathyroid hormone.

SP1 SP3 RUNX2

9.38e-083159319306294
Pubmed

Specificity of transcriptional regulation by the zinc finger transcription factors Sp1, Sp3, and Egr-1.

SP1 SP3 EGR1

9.38e-083159315523672
Pubmed

Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.

RC3H2 RPN2 NACA CAMSAP3 SREBF2 GON4L PFAS AP3B1 GTPBP2 DNAJC10 AP1B1 AP1G1 CCAR1 YTHDF2 MGRN1

3.44e-076501591538777146
Pubmed

Transcription of PRDM1, the master regulator for plasma cell differentiation, depends on an SP1/SP3/EGR-1 GC-box.

SP1 SP3 EGR1

3.74e-074159318604866
Pubmed

A human MAP kinase interactome.

SP1 SREBF2 CREB1 ZNF106 TSC22D1 USF3 POM121 BRAF EGR1 MACF1 BICRAL MBD5 GCN1

4.18e-074861591320936779
Pubmed

C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy.

TAPT1 MBOAT7 KIAA0319L SREBF2 RABGAP1 TRIP11 LYST DMXL1 SLC38A2 SLC7A2 GORASP2 TMEM131L TMEM131

6.29e-075041591334432599
Pubmed

Human transcription factor protein interaction networks.

SP1 NCOA6 RPN2 NACA ZBTB9 GON4L POU2F1 SRCAP RFX7 CREB1 NCOR1 HOXC11 ZFHX4 CCAR1 TAF4 MED17 TAF12 SAP130 LRIF1 YTHDF2 GNL3 MYB

6.50e-0714291592235140242
Pubmed

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.

HEXB TMEM67 FAT4 ABCB7 MBOAT7 RPN2 PIEZO1 KIAA0319L RABGAP1 DMXL1 IGSF10 SLC38A2 NPTN GORASP2 DNAJC10 NUP210 TMEM131L TMEM131 ALG3 MGRN1

6.62e-0712011592035696571
Pubmed

Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.

SP1 NCOA6 SP3 ZNF804A NCOR1 USF3 POM121 EGR1 SAP130 PRRC1 MRTFA MGRN1

7.60e-074301591235044719
Pubmed

Co-operative interactions between NFAT (nuclear factor of activated T cells) c1 and the zinc finger transcription factors Sp1/Sp3 and Egr-1 regulate MT1-MMP (membrane type 1 matrix metalloproteinase) transcription by glomerular mesangial cells.

SP1 SP3 EGR1

9.31e-075159314979875
Pubmed

Reciprocal regulation of expression of the human adenosine 5'-triphosphate binding cassette, sub-family A, transporter 2 (ABCA2) promoter by the early growth response-1 (EGR-1) and Sp-family transcription factors.

SP1 SP3 EGR1

9.31e-075159312560508
Pubmed

Transcription factor binding sites in the pol gene intragenic regulatory region of HIV-1 are important for virus infectivity.

SP1 SP3 POU2F1

9.31e-075159316061936
Pubmed

ZBP-89 represses vimentin gene transcription by interacting with the transcriptional activator, Sp1.

SP1 SP3 TAF4

9.31e-075159312771217
Pubmed

Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.

SP1 SP3 ZBTB20 ZNF180 POU2F1 RUNX2 SRCAP ATAD2 NCOR1 TSC22D1 EGR1 CCAR1 TAF12 NFAT5 MRTFA MYB

1.04e-068081591620412781
Pubmed

Activation of mouse RAG-2 promoter by Myc-associated zinc finger protein.

SP1 SP3 MYB

1.86e-066159315094381
Pubmed

Negative regulation of CD8 expression via Cd8 enhancer-mediated recruitment of the zinc finger protein MAZR.

NCOR1 CD8B CD8B2

1.86e-066159316491076
Pubmed

STAGA recruits Mediator to the MYC oncoprotein to stimulate transcription and cell proliferation.

TAF4 MED17 TAF12 MED13

1.92e-0620159417967894
Pubmed

Inflammation-dependent overexpression of c-Myc enhances CRL4DCAF4 E3 ligase activity and promotes ubiquitination of ST7 in colitis-associated cancer.

ABL1 RUNX2 TECTA CDCP1 NUP210 UBE3C BCAM GNL3 MRTFA

3.10e-06257159930945288
Pubmed

Augmented IL-10 production and redox-dependent signaling pathways in glucose-6-phosphate dehydrogenase-deficient mouse peritoneal macrophages.

SP1 SP3 CREB1

3.24e-067159315817708
Pubmed

PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.

NCOA6 ZBTB9 POU2F1 RUNX2 MED13L RUNX1 CREB1 NCOR1 AP1B1 EGR1 CCAR1 BICRAL TAF4 MED17 C2orf49 SAP130 LRIF1 MYB

3.31e-0611031591834189442
Pubmed

Majority of cerebrospinal fluid-contacting neurons in the spinal cord of C57Bl/6N mice is present in ectopic position unlike in other studied experimental mice strains and mammalian species.

SPATA31A3 SPATA31A7 SPATA31A5 SPATA31A1

4.16e-0624159432212159
Pubmed

Site-specific cross-linking reveals a differential direct interaction of class 1, 2, and 3 ADP-ribosylation factors with adaptor protein complexes 1 and 3.

AP3B1 AP1B1 AP1G1

5.16e-068159311926829
Pubmed

H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.

SP1 NCOA6 ZBTB20 RPN2 NR4A1 RUNX1 SRCAP RFX7 CREB1 NCOR1 ZNF106 HOXC11 CCAR1 TAF4 MED17 TAF12 SAP130 LRIF1 GNL3

7.89e-0612941591930804502
Pubmed

TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.

SP1 NCOA6 FAT4 MBOAT7 MUC16 REV3L AP3B1 TRIP11 TMEM200A SLC38A2 NCOR1 AP1B1 MED17

8.24e-066381591331182584
Pubmed

Impact of cytosine methylation on DNA binding specificities of human transcription factors.

SP1 SP3 ZBTB20 SOX30 SREBF2 NR4A1 RUNX2 RFX7 CREB1 HOXC11 EGR1 NFAT5

8.45e-065441591228473536
Pubmed

Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.

ABCB7 SREBF2 LMTK2 SRCAP AP3B1 CDCP1 SLC38A2 UBE2R2 BRAF AP1G1 TTLL4 TMEM131L MACF1 TMEM131 NFAT5 MRTFA TMEM18

1.06e-0510841591711544199
Pubmed

TGFβ attenuates cartilage extracellular matrix degradation via enhancing FBXO6-mediated MMP14 ubiquitination.

RPN2 CDCP1 NPTN DNAJC10 NUP210 LAMP3 TMEM131

1.11e-05164159732409323
Pubmed

Transcription factor AP-2 is expressed in neural crest cell lineages during mouse embryogenesis.

SP1 CD8B CD8B2

2.00e-051215931989904
Pubmed

The transcription factors Sp1 and Oct-1 interact physically to regulate human U2 snRNA gene expression.

SP1 POU2F1

2.08e-05215928668525
Pubmed

Sp1 increases expression of cyclooxygenase-2 in hypoxic vascular endothelium. Implications for the mechanisms of aortic aneurysm and heart failure.

SP1 SP3

2.08e-052159210825178
Pubmed

HPV8 activates cellular gene expression mainly through Sp1/3 binding sites.

SP1 SP3

2.08e-052159231299490
Pubmed

The cDNA cloning of the transcripts of human PEBP2alphaA/CBFA1 mapped to 6p12.3-p21.1, the locus for cleidocranial dysplasia.

RUNX2 RUNX1

2.08e-05215929233771
Pubmed

Genome-wide map of nuclear protein degradation shows NCoR1 turnover as a key to mitochondrial gene regulation.

CREB1 NCOR1

2.08e-052159224315104
Pubmed

Polyglutamylation is a post-translational modification with a broad range of substrates.

TTLL5 TTLL4

2.08e-052159218045879
Pubmed

Polycystin-1 regulates skeletogenesis through stimulation of the osteoblast-specific transcription factor RUNX2-II.

RUNX2 PKD1

2.08e-052159218321855
Pubmed

Lower serum CA125 level, negative vascular invasion, and wild BRAF were strongly associated with better 2-year disease-free survival in patients with stage III colorectal cancer who received adjuvant chemotherapy.

MUC16 BRAF

2.08e-052159229562502
Pubmed

Sp1/Sp3 transcription factors regulate hallmarks of megakaryocyte maturation and platelet formation and function.

SP1 SP3

2.08e-052159225538045
Pubmed

Hydroxycarbamide decreases sickle reticulocyte adhesion to resting endothelium by inhibiting endothelial lutheran/basal cell adhesion molecule (Lu/BCAM) through phosphodiesterase 4A activation.

PDE4A BCAM

2.08e-052159224616094
Pubmed

Receptor-like protein-tyrosine phosphatase α enhances cell surface expression of neural adhesion molecule NB-3.

CNTN6 PTPRA

2.08e-052159221622556
Pubmed

Glucocorticoids delay RAF-induced senescence promoted by EGR1.

BRAF EGR1

2.08e-052159231371485
Pubmed

Molecular cloning of Lyt-3, a membrane glycoprotein marking a subset of mouse T lymphocytes: molecular homology to immunoglobulin and T-cell receptor variable and joining regions.

CD8B CD8B2

2.08e-05215923035575
Pubmed

Molecular characterization of the murine cytotoxic T-cell membrane glycoprotein Ly-3 (CD8).

CD8B CD8B2

2.08e-05215923498943
Pubmed

c-Abl mediates high NaCl-induced phosphorylation and activation of the transcription factor TonEBP/OREBP.

ABL1 NFAT5

2.08e-052159220585028
Pubmed

Robust hematopoietic specification requires the ubiquitous Sp1 and Sp3 transcription factors.

SP1 SP3

2.08e-052159231164147
Pubmed

An immunological role for the CD8 beta-chain.

CD8B CD8B2

2.08e-05215921534146
Pubmed

Homozygous variants in the HEXB and MBOAT7 genes underlie neurological diseases in consanguineous families.

HEXB MBOAT7

2.08e-052159231852446
Pubmed

Interaction between intrinsically disordered regions in transcription factors Sp1 and TAF4.

SP1 TAF4

2.08e-052159227515574
Pubmed

Expression of the Pkd1 gene is momentously regulated by Sp1.

SP1 PKD1

2.08e-052159217890878
Pubmed

Transcriptional activity and Sp 1/3 transcription factor binding to the P1 promoter sequences of the human AbetaH-J-J locus.

SP1 SP3

2.08e-052159217681019
Pubmed

Endothelial Sp1/Sp3 are essential to the effect of captopril on blood pressure in male mice.

SP1 SP3

2.08e-052159237735515
Pubmed

Sp1 and Sp3 Are the Transcription Activators of Human ek1 Promoter in TSA-Treated Human Colon Carcinoma Cells.

SP1 SP3

2.08e-052159226807725
Pubmed

Duality of the murine CD8 compartment.

CD8B CD8B2

2.08e-052159224594598
Pubmed

Disruption of T lymphocyte positive and negative selection in mice lacking the CD8 beta chain.

CD8B CD8B2

2.08e-05215927889415
Pubmed

The nonreceptor tyrosine kinase c-Abl phosphorylates Runx1 and regulates Runx1-mediated megakaryocyte maturation.

ABL1 RUNX1

2.08e-052159229730354
Pubmed

AKXD recombinant inbred strains: models for studying the molecular genetic basis of murine lymphomas.

CD8B CD8B2

2.08e-05215923025647
Pubmed

Sp1/Sp3-dependent regulation of human telomerase reverse transcriptase promoter activity by the bioactive sphingolipid ceramide.

SP1 SP3

2.08e-052159215951564
Pubmed

Influence of Phosphodiesterase Inhibition on CRE- and EGR1-Dependent Transcription in a Mouse Hippocampal Cell Line.

CREB1 EGR1

2.08e-052159233212816
Pubmed

Gene transfer of the Ly-3 chain gene of the mouse CD8 molecular complex: co-transfer with the Ly-2 polypeptide gene results in detectable cell surface expression of the Ly-3 antigenic determinants.

CD8B CD8B2

2.08e-05215922452747
Pubmed

Distinct methylation states of the CD8 beta gene in peripheral T cells and intraepithelial lymphocytes.

CD8B CD8B2

2.08e-05215929233619
Pubmed

Transcription factors Sp1 and Sp3 regulate basal transcription of the human IRF-3 gene.

SP1 SP3

2.08e-052159222464952
Pubmed

The human TFIID components TAF(II)135 and TAF(II)20 and the yeast SAGA components ADA1 and TAF(II)68 heterodimerize to form histone-like pairs.

TAF4 TAF12

2.08e-052159210594036
Pubmed

Stalk region of beta-chain enhances the coreceptor function of CD8.

CD8B CD8B2

2.08e-052159212847256
Pubmed

Sp1 trans-activation of cell cycle regulated promoters is selectively repressed by Sp3.

SP1 SP3

2.08e-05215928845379
Pubmed

Runx2/Cbfa1, but not loss of myocardin, is required for smooth muscle cell lineage reprogramming toward osteochondrogenesis.

RUNX2 MYOCD

2.08e-052159220564193
Pubmed

Transcriptional diversity at the duplicated human CD8 beta loci.

CD8B CD8B2

2.08e-05215928436166
Pubmed

Immunocytochemistry for MUC4 and MUC16 is a useful adjunct in the diagnosis of pancreatic adenocarcinoma on fine-needle aspiration cytology.

MUC16 MUC4

2.08e-052159223544943
Pubmed

Interaction of the co-activator CBP with Myb proteins: effects on Myb-specific transactivation and on the cooperativity with NF-M.

CREB1 MYB

2.08e-05215928654374
Pubmed

Expression of the human endogenous retrovirus (HERV) group HML-2/HERV-K does not depend on canonical promoter elements but is regulated by transcription factors Sp1 and Sp3.

SP1 SP3

2.08e-052159221248046
Pubmed

Fluid shear stress induces Runx-2 expression via upregulation of PIEZO1 in MC3T3-E1 cells.

PIEZO1 RUNX2

2.08e-052159232181967
Pubmed

A TFIID-SAGA Perturbation that Targets MYB and Suppresses Acute Myeloid Leukemia.

TAF4 TAF12

2.08e-052159229316427
Pubmed

Sp1 and Sp3 activate transcription of the human dopamine transporter gene.

SP1 SP3

2.08e-052159215816870
Pubmed

Structure and expression of the Lyt-3a gene of C.AKR mice.

CD8B CD8B2

2.08e-05215923169881
Pubmed

Sp family transcription factors regulate expression of rat D2 dopamine receptor gene.

SP1 SP3

2.08e-05215929628590
Pubmed

The nuclear abundance of transcription factors Sp1 and Sp3 depends on biotin in Jurkat cells.

SP1 SP3

2.08e-052159214608051
Pubmed

Esr, a second locus in the house mouse controlling esterase-5.

CD8B CD8B2

2.08e-05215927103930
Pubmed

Runx1/AML1/Cbfa2 mediates onset of mesenchymal cell differentiation toward chondrogenesis.

RUNX2 RUNX1

2.08e-052159216059634
Pubmed

Differentiation-dependent and cell-specific regulation of the hIGFBP-1 gene in human endometrium.

SP1 SP3

2.08e-05215929329821
Pubmed

Nuclear pore complex assembly and maintenance in POM121- and gp210-deficient cells.

POM121 NUP210

2.08e-052159216702234
Pubmed

Ly-C: a third locus specifying alloantigens expressed only on thymocytes and lymphocytes.

CD8B CD8B2

2.08e-05215925558567
Pubmed

RUNX1 and RUNX2 transcription factors function in opposing roles to regulate breast cancer stem cells.

RUNX2 RUNX1

2.08e-052159232180230
Pubmed

Mediator complex component MED13 regulates zygotic genome activation and is required for postimplantation development in the mouse.

MED13L MED13

2.08e-052159229325037
Pubmed

T-cell receptor signaling induces proximal Runx1 transactivation via a calcineurin-NFAT pathway.

RUNX1 NFAT5

2.08e-052159224310293
Pubmed

O-GlcNAc modification of Sp1 inhibits the functional interaction between Sp1 and Oct1.

SP1 POU2F1

2.08e-052159219070619
Pubmed

Cloning and modeling of CD8 beta in the amphibian ambystoma Mexicanum. Evolutionary conserved structures for interactions with major histocompatibility complex (MHC) class I molecules.

CD8B CD8B2

2.08e-052159212034498
Pubmed

Disease mutations in RUNX1 and RUNX2 create nonfunctional, dominant-negative, or hypomorphic alleles.

RUNX2 RUNX1

2.08e-052159217290219
Pubmed

Myocardin and myocardin-related transcription factor-A synergistically mediate actin cytoskeletal-dependent inhibition of liver fibrogenesis.

MYOCD MRTFA

2.08e-052159231928221
Pubmed

Concentration-dependent effects of endogenous S-nitrosoglutathione on gene regulation by specificity proteins Sp3 and Sp1.

SP1 SP3

2.08e-052159214766015
Pubmed

Crystal structure of a subcomplex of human transcription factor TFIID formed by TATA binding protein-associated factors hTAF4 (hTAF(II)135) and hTAF12 (hTAF(II)20).

TAF4 TAF12

2.08e-052159212237304
Pubmed

The CAMSAP3-ACF7 Complex Couples Noncentrosomal Microtubules with Actin Filaments to Coordinate Their Dynamics.

CAMSAP3 MACF1

2.08e-052159227693509
Pubmed

Oct-1 counteracts autoinhibition of Runx2 DNA binding to form a novel Runx2/Oct-1 complex on the promoter of the mammary gland-specific gene beta-casein.

POU2F1 RUNX2

2.08e-052159215798204
Pubmed

Identification of heteromolecular binding sites in transcription factors Sp1 and TAF4 using high-resolution nuclear magnetic resonance spectroscopy.

SP1 TAF4

2.08e-052159228857320
Pubmed

Megakaryoblastic leukemia factor-1 transduces cytoskeletal signals and induces smooth muscle cell differentiation from undifferentiated embryonic stem cells.

MYOCD MRTFA

2.08e-052159214970199
InteractionNR3C1 interactions

SP1 NCOA6 FAT4 ZBTB20 MBOAT7 RPN2 ZBTB9 MUC16 POU2F1 REV3L NR4A1 AP3B1 CREB1 TRIP11 TMEM200A SLC38A2 NCOR1 AP1B1 EGR1 NUP210 BCAM MED17 LRIF1

9.97e-0797415123int:NR3C1
InteractionFHL2 interactions

SP1 SP3 SOX30 SREBF2 RUNX2 RUNX1 CREB1 NCOR1 ZNF106 CCAR1 NFAT5 SAP130 LRIF1 MRTFA

1.75e-0639615114int:FHL2
InteractionZBTB7B interactions

SP1 SP3 SREBF2 RUNX2 RUNX1 ATAD2 CREB1 HOXC11 ZFHX4 NFAT5 YTHDF2 MED13 GNL3

3.97e-0636615113int:ZBTB7B
InteractionTBP interactions

BDP1 SP1 NCOA6 SP3 NACA POU2F1 PYHIN1 EGR1 TAF4 TAF12

2.17e-0525315110int:TBP
InteractionHIF1A interactions

SP1 NR4A1 RUNX2 MED13L RUNX1 CREB1 NUP210 PLD2 UBE3C CDC34 GCN1 MED13 GNL3

2.87e-0544115113int:HIF1A
GeneFamilyGATA zinc finger domain containing|Myb/SANT domain containing

BDP1 GON4L NCOR1 MYB

1.79e-0453964532
GeneFamilyCD molecules|Mucins

MUC16 MUC4 MUC7

1.80e-0421963648
GeneFamilyCyclins|Mediator complex

MED13L MED17 MED13

7.05e-04339631061
GeneFamilyZinc fingers C2H2-type|Sp transcription factors

SP1 SP3

9.80e-049962755
GeneFamilyBlood group antigens|CD molecules|I-set domain containing|Immunoglobulin like domain containing

NRG2 MDGA2 CNTN6 IGSF10 NPTN

1.68e-03161965593
GeneFamilyTubulin tyrosine ligase family

TTLL5 TTLL4

2.44e-0314962779
GeneFamilyCadherin related

DCHS2 FAT4

3.60e-031796224
CoexpressionGSE27241_WT_VS_RORGT_KO_TH17_POLARIZED_CD4_TCELL_TREATED_WITH_DIGOXIN_UP

SP1 RFX7 ATAD2 NCOR1 ZNF106 TTLL4 MACF1 NFAT5 MED13

1.47e-061801579M8239
CoexpressionDACOSTA_UV_RESPONSE_VIA_ERCC3_DN

SP3 ZBTB20 MAMLD1 RABGAP1 REV3L MED13L RUNX1 AP3B1 CREB1 ZNF804A PTPRA TMEM131L MACF1 TMEM131 BICRAL TAF4 MED13 MRTFA

4.04e-0685615718M4500
CoexpressionGSE2770_IL12_AND_TGFB_VS_IL4_TREATED_ACT_CD4_TCELL_2H_UP

RC3H2 MAMLD1 GON4L RUNX1 TRIP11 TSC22D1 NFAT5 MED13

2.69e-051981578M6123
CoexpressionGSE22886_TH1_VS_TH2_48H_ACT_DN

HEXB PDE4A RPN2 CD164 RUNX1 CDCP1 PTPRA MBD5

2.89e-052001578M4512
CoexpressionGSE23114_PERITONEAL_CAVITY_B1A_BCELL_VS_SPLEEN_BCELL_DN

SP3 MBOAT7 RPN2 MAMLD1 SREBF2 RUNX1 LAMP3 ALG3

2.89e-052001578M8297
CoexpressionAtlasFacebaseRNAseq_e10.5_Lateral Nasal Eminence_top-relative-expression-ranked_2500_k-means-cluster#1

BDP1 NCOA6 ZBTB38 ZNF180 TTLL5 GON4L POU2F1 RABGAP1 REV3L AP3B1 UBE2R2 USF3 CCAR1 TMEM131L MACF1 MBD5 TAF12 C2orf49

1.25e-0578015218Facebase_RNAseq_e10.5_Lateral Nasal Eminence_2500_K1
CoexpressionAtlasFacebaseRNAseq_e10.5_Maxillary Arch_top-relative-expression-ranked_1000

BDP1 ZBTB20 CENPT PRR36 CAMSAP3 MAMLD1 POU2F1 REV3L RUNX2 AP3B1 ZFHX4 EGR1 CCAR1 MACF1 TMEM131 BCAM MED17 TSACC MUC4 LRIF1

2.69e-0598915220Facebase_RNAseq_e10.5_Maxillary Arch_1000
CoexpressionAtlasFacebaseRNAseq_e10.5_Neural Epithelium Flanking Eminence_top-relative-expression-ranked_2500_k-means-cluster#5

BDP1 NCOA6 ZBTB38 ZBTB20 ZNF180 MAMLD1 GON4L MDGA2 AP3B1 NCOR1 UBE2R2 PTPRZ1 NUP210 CCAR1 TMEM131L TAF12 C2orf49 MRTFA

2.89e-0583115218Facebase_RNAseq_e10.5_Neural Epithelium Flanking Eminence_2500_K5
CoexpressionAtlasdev gonad_e11.5_F_SupCellPrec_Sry_top-relative-expression-ranked_1000

SP3 FAT4 PIEZO1 CAMSAP3 MUC16 REV3L MED13L RUNX1 AP3B1 MEX3C SLC38A2 SLC7A2 TSC22D1 ZFHX4 TMEM131L NFAT5 MRTFA

5.37e-0579115217gudmap_dev gonad_e11.5_F_SupCellPrec_Sry_1000
ToppCelldroplet-Heart-nan-3m|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZBTB38 ZBTB20 CPED1 TRIP11 LYST IGSF10 ZNF106 MACF1 MYOCD

1.42e-081761589749b47eac5436fa34e0d243ffbc6f1897f4e431e
ToppCell10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8|GI_small-bowel / Manually curated celltypes from each tissue

ZBTB20 MED13L BRAF AP1G1 TMEM131L MACF1 TMEM131 NFAT5 MED13

2.52e-081881589ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCelldroplet-Limb_Muscle-MUSCLE-30m-Mesenchymal|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZBTB38 ZBTB20 RUNX1 CPED1 TRIP11 IGSF10 ZFHX4 EGR1

4.98e-0719515885c86fddd6d0530beecf45ea5ba6b823123847696
ToppCellTCGA-Brain-Primary_Tumor-Low_Grade_Glioma-Oligodendroglioma-3|TCGA-Brain / Sample_Type by Project: Shred V9

RC3H2 POU2F1 MED13L RFX7 ZNF804A EYS TMEM236

5.48e-071351587b128596653a5e3b64ed7f657bbfeda35438e2e48
ToppCelldroplet-Lung-30m-Hematologic-myeloid-intermediate_monocyte-intermediate_monocyte_l33|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

TMEM67 ZGRF1 TTLL5 LMTK2 REV3L RFX7 DNAJC10

5.76e-071361587a43b3db1754c619d328a26a2ba6af4756629a723
ToppCellTCGA-Ovary-Primary_Tumor-Ovarian_Carcinoma-Serous_Cystadenocarcinoma-5|TCGA-Ovary / Sample_Type by Project: Shred V9

SP1 GON4L POU2F1 USF3 STPG1 MBD5 IMPG2

2.19e-06166158732d2eaf8a5d03881bf74d680825af2d5110b082d
ToppCellfacs-Brain_Myeloid-Cerebellum-3m-Myeloid-nan|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SP3 RUNX1 SLC38A2 NPTN ZNF106 EGR1 MACF1

2.88e-061731587869da6a65d1b9b7529c666ec44e3c8ddec2ea408
ToppCellfacs-Brain_Myeloid-Cerebellum-3m-Myeloid|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SP3 RUNX1 SLC38A2 NPTN ZNF106 EGR1 MACF1

2.88e-0617315870672bd8a4a9d18af343d01f09253fb3388896c10
ToppCellfacs-Brain_Myeloid-Cerebellum-3m|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SP3 RUNX1 SLC38A2 NPTN ZNF106 EGR1 MACF1

2.88e-061731587870e091ec30be01a900e1cb8b9ef1880e3b7b50d
ToppCelldroplet-Marrow-nan-3m|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TRIP11 LYST PYHIN1 NCOR1 ZNF106 EGR1 MACF1

4.32e-0618415871154a5ad7b8512272b7476f949ddac350910bfb7
ToppCelldroplet-Spleen-nan-3m|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NACA TRIP11 LYST DMXL1 PYHIN1 CD8B MACF1

4.64e-06186158726f1e9930adf2fe4af0819e56f69915bd8330e4a
ToppCellTCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-1|TCGA-Pancreas / Sample_Type by Project: Shred V9

SP1 SP3 RABGAP1 CREB1 TMEM131 NFAT5 SAP130

4.64e-06186158703db813598b67b1e08f759758a1c2023396921fa
ToppCell368C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_3|CD8+_Cytotoxic_T-cell / Donor, Lineage, Cell class and subclass (all cells)

ABCB7 CENPT TAPT1 KIAA0319L GORASP2 AP1G1 UBE3C

5.34e-061901587651a1d3ae286e40f9d9f60e438211c6148d24143
ToppCelldroplet-Limb_Muscle-MUSCLE-30m-Mesenchymal-mesenchymal_stem_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RUNX1 CPED1 TRIP11 IGSF10 ZFHX4 EGR1 CLEC3B

5.72e-06192158711088878043a6ff95ba1970361256a82e434b80a
ToppCellfacs-Brain_Myeloid-Hippocampus-3m-Myeloid|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HEXB CD164 NPTN PTPRA EGR1 MACF1 YTHDF2

5.92e-06193158706b65110db974f4ef90d3511ff34428976a52c9c
ToppCellfacs-Brain_Myeloid-Hippocampus-3m-Myeloid-microglial_cell|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HEXB CD164 NPTN PTPRA EGR1 MACF1 YTHDF2

5.92e-0619315879c16032bc03df8760ae199e8f19fdafa4c3f1827
ToppCellfacs-Brain_Myeloid-Hippocampus-3m|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HEXB CD164 NPTN PTPRA EGR1 MACF1 YTHDF2

5.92e-061931587a4f91bca5eaa985982d33a528f7566ffde154d47
ToppCellfacs-Brain_Myeloid-Hippocampus-3m-Myeloid-nan|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HEXB CD164 NPTN PTPRA EGR1 MACF1 YTHDF2

5.92e-061931587b39d7feaac4ff8f7409cd3d15e8f3c6391367275
ToppCellfacs-Thymus-nan-3m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SP3 TAPT1 CD164 COLQ LYST CD8B MYB

6.33e-06195158779114b3c78cc15c413bb58f0673e7215b784a9b6
ToppCellfacs-Bladder-nan-3m|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZBTB20 REV3L IGSF10 NPTN PTPRA EGR1 MACF1

6.55e-06196158744f5b1b474399c9316729155f2ea95a82ca66e30
ToppCellfacs-Bladder-nan-3m-Epithelial|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZBTB20 REV3L IGSF10 NPTN PTPRA EGR1 MACF1

6.55e-061961587c0e90d964baa2eb4fbd18a52379ccec5d3bf59a8
ToppCell3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Alveolar_fibroblasts-Alveolar_fibroblasts_L.2.1.1.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FAT4 ANK2 IGSF10 ZNF106 PLPPR4 EGR1 MACF1

6.77e-06197158794a9603cbd3516fbcce871909693b88f20d41713
ToppCell21-Trachea-Epithelial|Trachea / Age, Tissue, Lineage and Cell class

RUNX1 NPTN TSC22D1 EGR1 ATP2C2 BCAM MUC4

7.23e-0619915878eb8b086c38960200578a9fe8853ca6e894ddee4
ToppCellICU-NoSEP-Lymphocyte-T_NK-CD4_TEM|ICU-NoSEP / Disease, Lineage and Cell Type

ZBTB20 PRR36 TMEM200A AMIGO3 GYS2 IMPG2

2.16e-0515815868616b308d5c1a1042b23a9aaca971029ba732eb8
ToppCell356C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_1|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

RC3H2 ZBTB38 MUC16 LYST PYHIN1 CD8B

2.48e-0516215864b9f80f701dcbb2508f497095cb8a7a2ca51cb5e
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Pygm_C1ql1|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

ZBTB20 ZNF804A TMEM200A SLC44A5 PTPRZ1 BCAM

3.04e-051681586f3879a8e11eaf866f37c52e67021be43f0b8784a
ToppCellSmart-seq2-tissue-resident_(Smart-seq2)-myeloid-myeloid_dendritic-CD1c-positive_myeloid_dendritic_cell|tissue-resident_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

SLC36A4 MAMLD1 CDCP1 LAMP3 PLD2 MUC4

3.25e-051701586cc66ac6846c58be9493eb270644ee3ce0f86cfea
ToppCell3'-Airway_Nasal-Epithelial-Airway_epithelium-respiratory_basal_cell-Basal_resting-Basal_resting_L.0.0.0.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

B4GALNT4 NR4A1 TSC22D1 EGR1 PTPRZ1 BCAM

3.36e-051711586ea60d9e9df28ab991fbdb596784b44f6a9fc5827
ToppCell3'-Broncho-tracheal-Immune_Lymphocytic-Lymphocytic_T/NK-natural_killer_cell-NK_cells-|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DPH1 PYHIN1 PTPRA CD8B TTLL4 C2orf49

3.83e-05175158626bd957498e41a3f1ffa60d3effa27ca8c4ba631
ToppCell(03)_Secretory-(4)_1wkpi|(03)_Secretory / shred by cell type and Timepoint

HEXB NR4A1 NPTN EGR1 ATP2C2 NFAT5

3.83e-05175158606b52f85baa31b55bb31477244892b6da79fe2c9
ToppCell3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.5|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

LMTK2 MUC16 NR4A1 ATP2C2 MACF1 MUC4

4.34e-0517915866e965e424eebef50f0202cff75f458be395cfca1
ToppCelldroplet-Marrow-nan-3m-Myeloid|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TRIP11 LYST PYHIN1 ZNF106 EGR1 MACF1

5.21e-0518515867adfa929930cfa795cbfbd9f1a0b439e08aa765d
ToppCell(00)_Basal-(4)_1wkpi|(00)_Basal / shred by cell type and Timepoint

NR4A1 SLC38A2 NPTN CD8B EGR1 PTPRZ1

5.21e-051851586bf82ba905e5eee1c39a2731702071d3de10a78b8
ToppCellCV-Moderate-7|CV / Virus stimulation, Condition and Cluster

RUNX2 TMEM200A SLC38A2 TMEM131L MACF1 NFAT5

5.37e-0518615868571956890fc9894d766ba294a28e376b4aba428
ToppCellPCW_13-14|World / Celltypes from embryonic and fetal-stage human lung

ZBTB38 ZBTB20 NCOR1 PLPPR4 MACF1 MBD5

6.04e-05190158662a3ec1ae0829602b0569cc051210551644f1d46
ToppCellPCW_05-06-Mesenchymal-Mesenchymal_myocytic-mes_proliferating_SM_(20)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

ZGRF1 RTTN ATAD2 CPED1 PLPPR4 MYOCD

6.04e-051901586e83fa8b711aa79a1767818474f1c193b674b1c31
ToppCelldroplet-Limb_Muscle-MUSCLE-30m-Mesenchymal-nan|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZBTB20 RUNX1 TRIP11 ZFHX4 EGR1 CLEC3B

6.22e-0519115867d1595e616f6f111fc2f5bc1b179c5d67d624cc9
ToppCellPND07|World / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

NR4A1 IGSF10 NPTN EGR1 MACF1 CLEC3B

6.40e-0519215868171a60df481195c39a7f740effcae8e4deb6ca7
ToppCellnucseq|World / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

ZBTB20 MED13L RUNX1 BRAF NFAT5 MRTFA

6.59e-051931586779276e775cb2492e8dd36436295a536084a6415
ToppCellTCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma-Acinar_Adenocarcinoma-6|TCGA-Prostate / Sample_Type by Project: Shred V9

POU2F1 CREB1 TRIP11 USF3 PRRC1 MED13

6.59e-051931586abd71b2cf667ef2b1c4d88acd0c1dd19a12ff659
ToppCellfacs-Large_Intestine-Distal-3m-Epithelial-Reg4/cKit+_deep_crypt_secretory_cells_(Distal)|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HEXB CD164 NR4A1 DNAJC10 ATP2C2 MUC4

6.59e-0519315864aee372ba2c0351b0221d0d468707d1ad21526d6
ToppCellControl-CD8+_T_naive|Control / Disease condition and Cell class

NR4A1 RUNX2 CD8B CD8B2 EGR1 MYB

6.59e-051931586627d345baf1940218c61907305705298e473dbab
ToppCellfacs-Thymus-nan-3m-Lymphocytic-DN_to_DP_transition_(most_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TAPT1 CD164 COLQ LYST CD8B MYB

6.59e-051931586a6a864644e1b80b7417ea0a27281e79068a3fd3d
ToppCell3'-Broncho-tracheal-Epithelial-Airway_epithelium-respiratory_basal_cell-Basal_resting-Basal_resting_L.0.0.0.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

NR4A1 SLC38A2 TSC22D1 EGR1 PTPRZ1 BCAM

6.59e-051931586739fb2a57772a800a2e94bdd6c71285bb2c162a7
ToppCellfacs-Large_Intestine-Distal-3m-Epithelial-secretory_cell|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HEXB CD164 NR4A1 DNAJC10 ATP2C2 MUC4

6.59e-051931586aaa5042388dc451bff384c6bb237348f08280a08
ToppCellfacs-Thymus-nan-3m|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TAPT1 CD164 COLQ LYST CD8B MYB

6.78e-051941586f1661f9f2439fca5c1012c693b0744c4e3b90a9b
ToppCellfacs-Brain_Myeloid-Cortex-3m-Myeloid-microglial_cell|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HEXB CD164 NPTN AP1B1 EGR1 GCN1

6.78e-0519415862224c7c943cfd5c1a329dfcf19d6e5ef8c49d85d
ToppCellSmart-seq2-lymph_node_(Smart-seq2)-lymphocytic-B_lymphocytic-B_cell|lymph_node_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

SREBF2 NR4A1 LYST DMXL1 DNAJC10 AP1B1

6.78e-051941586ff661419b697aef51a53fdeac8d37d870d65f491
ToppCellfacs-Thymus-nan|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TAPT1 CD164 COLQ LYST CD8B MYB

6.78e-051941586cda1b197efb199330ea7ab25a7cee22cae22589d
ToppCellfacs-Thymus-nan-3m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TAPT1 CD164 COLQ LYST CD8B MYB

6.78e-05194158666c056232ac216780acf4cc8ea325bd8ed1909c9
ToppCellCOVID-19-kidney-Fibroblast-2|COVID-19 / Disease (COVID-19 only), tissue and cell type

MAMLD1 REV3L CPED1 TMEM200A SLC7A2 ZFHX4

6.98e-0519515863d62ce1c696f47d4d7eb0c5bb0eec2c24b122bb2
ToppCell3'-Child09-12-SmallIntestine-Epithelial-goblet|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CD164 NR4A1 DNAJC10 EGR1 ATP2C2 MUC4

7.18e-051961586c2d17630f7bfc9e727de55e093c17fddac61b61f
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW09-Macroglial-Glia_progenitor_cell|GW09 / Sample Type, Dataset, Time_group, and Cell type.

LMTK2 COLQ CNTN6 DNAJC10 AP1G1 TAF4

7.18e-0519615867be50b9156394dea44d7b8b476d4dd516abfafae
ToppCell3'-Child09-12-SmallIntestine-Epithelial-goblet-Goblet_cell|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CD164 NR4A1 DNAJC10 EGR1 ATP2C2 MUC4

7.18e-05196158654c30023d04e7265373647f56fc93885804938b0
ToppCellBronchial_Biopsy-Epithelial-Basal_1|Bronchial_Biopsy / Tissue, Lineage and Cell class of Lung Cells from 10X

NR4A1 SLC38A2 TSC22D1 EGR1 PTPRZ1 BCAM

7.38e-051971586a4855c5aebea4f0fed4eb035844572e82e5bac46
ToppCell10x3'2.3-week_17-19|World / cell types per 3 fetal stages;per 3',per 5'

TAPT1 NR4A1 MEX3C SLC38A2 EGR1 MYB

7.38e-051971586f5cfad0b42d0f817e22cc78b9bfb2b4b7e4330ed
ToppCellBronchial_Biopsy-Epithelial-Basal_1|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X

NR4A1 SLC38A2 TSC22D1 EGR1 PTPRZ1 BCAM

7.38e-05197158661c1c29a62d4c033999b7f0183c1e9cdd6a62925
ToppCellParenchymal-NucSeq-Epithelial-Epi_airway_secretory-Secretory_Club|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

RUNX2 RUNX1 CNTN6 SLC44A5 EGR1 MUC4

7.59e-0519815861408e02e053ad3406229bfe8189da03be6366e81
ToppCell21-Trachea-Epithelial-Basal_cell|Trachea / Age, Tissue, Lineage and Cell class

NR4A1 TSC22D1 EGR1 PTPRZ1 ATP2C2 BCAM

7.59e-0519815866ed75b53030028be915a90c0bca4d12e471914a5
ToppCellmild-low-quality_cells|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

BDP1 ZBTB20 RTTN PYHIN1 BRAF MACF1

7.80e-051991586f0b0097df0026496470a80d8cc9375ffd8389b00
ToppCell3'-Broncho-tracheal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.2.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DCHS2 TSC22D1 EGR1 PTPRZ1 BCAM MUC4

7.80e-0519915864099df3c052a9536d72ba01492317be7d83a79ad
ToppCellmLN-ILC-ILC|mLN / Region, Cell class and subclass

ESPN PDE4A MBOAT7 NR4A1 RUNX2 EGR1

7.80e-051991586ab09a06cdea2597e9fe4b4b304655e9de4d433f6
ToppCellmLN-ILC|mLN / Region, Cell class and subclass

ESPN PDE4A MBOAT7 NR4A1 RUNX2 EGR1

7.80e-051991586d6c299312c747fb1b7c53644c53efc03a5fffe85
ToppCellmLN-(3)_ILC|mLN / shred on region, Cell_type, and subtype

ESPN PDE4A MBOAT7 NR4A1 RUNX2 EGR1

7.80e-05199158600e0e2a766dd9c4d0a65f53d88fa50df4b6a3d60
ToppCellmLN-(3)_ILC-(30)_ILC|mLN / shred on region, Cell_type, and subtype

ESPN PDE4A MBOAT7 NR4A1 RUNX2 EGR1

7.80e-05199158633ac6d77099076df01299be429f4ba96f2f34cc1
ToppCellBronchial_Biopsy-Epithelial|Bronchial_Biopsy / Tissue, Lineage and Cell class of Lung Cells from 10X

MUC16 RUNX1 TSC22D1 PTPRZ1 ATP2C2 MUC4

7.80e-051991586ef5d8917c8d011184830a0b8197afc6266707b37
ToppCellParenchymal-NucSeq-Epithelial-Epi_submucosal-gland-SMG_Duct|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

DCHS2 MUC16 RUNX2 RUNX1 PTPRZ1 MUC4

8.02e-052001586b992eeddee38e6fe3564e9b1850f6b20b89bf47d
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Epithelial-Epithelial,_Airway-squamous_epithelial_cell|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

LMTK2 MUC16 CDCP1 TSC22D1 LAMP3 MUC4

8.02e-0520015861c02a7f4047d1d2208cc522c6bb4a4989d7845bb
ToppCellNS-control|NS / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

MUC16 SLC7A2 TSC22D1 PTPRZ1 BCAM MUC4

8.02e-052001586ecbe89ff95d046155b984c8c150e0b9e7278f839
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Epithelial-Epithelial,_Airway-squamous_epithelial_cell-Epi-Squamous|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

LMTK2 MUC16 CDCP1 TSC22D1 LAMP3 MUC4

8.02e-05200158603051d2190244208905e1611019d4b8fd200bae0
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Gpc3_Slc18a3|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

ZBTB20 TECTA ZNF804A SLC44A5 PTPRZ1

1.29e-041371585d346086f42d8f04d3fa67fe696834284acdc7080
DrugStrophanthidin [66-28-4]; Up 200; 9.8uM; HL60; HT_HG-U133A

SP1 RC3H2 TTLL5 POU2F1 NR4A1 RUNX1 CREB1 AP1G1 EGR1 NFAT5

1.57e-07166150102525_UP
DrugMethapyrilene hydrochloride [135-23-9]; Up 200; 13.4uM; HL60; HG-U133A

CD164 CREB1 NCOR1 DNAJC10 AP1G1 MACF1 PLD2 MED17 CA7

6.84e-0619815091588_UP
DrugBiotin [58-85-5]; Down 200; 16.4uM; HL60; HT_HG-U133A

RC3H2 CENPT TTLL5 RUNX1 AP3B1 BRAF MACF1 NFAT5 MRTFA

6.84e-0619815092428_DN
DrugHelveticoside [630-64-8]; Up 200; 7.4uM; MCF7; HT_HG-U133A

TTLL5 NACA POU2F1 NR4A1 RUNX1 SLC38A2 EGR1 NFAT5

1.54e-0516715086047_UP
DrugLanatoside C [17575-22-3]; Up 200; 4uM; HL60; HT_HG-U133A

GON4L POU2F1 RABGAP1 NR4A1 RUNX1 CREB1 AP1G1 EGR1

1.68e-0516915082193_UP
Drug1,4-bis-(phenoxyacetyl)piperazine

SP1 CD164 POU2F1 AP3B1 CREB1 LYST AP1B1 AP1G1 LAMP3

1.90e-052251509CID001008511
DrugClomipramine hydrochloride [17321-77-6]; Up 200; 11.4uM; MCF7; HT_HG-U133A

PDE4A SOX30 NR4A1 RUNX1 SRCAP EGR1 MAGEC1 MRTFA

3.89e-0519015086825_UP
DrugHydroxytacrine maleate (R,S) [118909-22-1]; Down 200; 12.2uM; HL60; HT_HG-U133A

MBOAT7 TTLL5 KIAA0319L GON4L RABGAP1 RUNX1 SRCAP CDCP1

4.51e-0519415082430_DN
DrugSpiramycin [8025-81-8]; Down 200; 4.8uM; MCF7; HT_HG-U133A

KIAA0319L RABGAP1 NR4A1 TRIP11 PYHIN1 HOXC11 NFAT5 MRTFA

4.51e-0519415083938_DN
Drugfullerene C60

ESPN NCOA6 B4GALNT4 ZBTB38 ABL1 ZBTB20 MBOAT7 PIEZO1 NRG2 CCDC187 POU2F1 PFAS RUNX2 SRCAP NCOR1 GTPBP2 AP1B1 GYS2 PLD2 BCAM TAF12 MUC4 MUC7 MED13

4.53e-05149815024ctd:C069837
DrugCefmetazole sodium salt [56796-39-5]; Down 200; 8.2uM; PC3; HT_HG-U133A

TTLL5 SREBF2 NRG2 MED13L RUNX1 MEX3C NUP210 BICRAL

4.85e-0519615085868_DN
DrugPivmecillinam hydrochloride [32887-03-9]; Down 200; 8.4uM; PC3; HT_HG-U133A

KIAA0319L NRG2 RABGAP1 RUNX1 GTPBP2 BICRAL PLD2 MYB

4.85e-0519615087312_DN
DrugBuflomedil hydrochloride [35543-24-9]; Up 200; 11.6uM; HL60; HT_HG-U133A

RC3H2 CENPT TTLL5 RUNX1 CDCP1 BRAF EGR1 NFAT5

4.85e-0519615081338_UP
DrugMCC-555

RUNX2 LYST GYS2 TAF12

4.96e-05311504CID000204109
DrugStreptomycin sulfate [3810-74-0]; Down 200; 2.8uM; HL60; HG-U133A

MGAM PDE4A NACA NR4A1 NCOR1 PTPRA EGR1 MED13

5.02e-0519715081578_DN
DrugCalciferol [50-14-6]; Up 200; 10uM; PC3; HT_HG-U133A

PRTN3 ZBTB20 TTLL5 RUNX1 PLPPR4 TTLL4 MUC7 MRTFA

5.21e-0519815086746_UP
DrugCephapirin sodium salt [24356-60-3]; Down 200; 9uM; HL60; HT_HG-U133A

RC3H2 NRG2 RUNX1 SRCAP NOD2 NCOR1 ZFHX4 EGR1

5.21e-0519815082730_DN
DrugDacarbazine [4342-03-4]; Up 200; 22uM; MCF7; HT_HG-U133A

PRR36 KIAA0319L LMTK2 NR4A1 RUNX1 TTLL4 LAMP3 IMPG2

5.21e-0519815082754_UP
DrugZidovudine, AZT [30516-87-1]; Up 200; 15uM; MCF7; HT_HG-U133A

CENPT TTLL5 KIAA0319L TRIP11 EGR1 TTLL4 NUP210 LAMP3

5.39e-0519915085333_UP
DrugZoxazolamine [61-80-3]; Up 200; 23.8uM; HL60; HT_HG-U133A

TAPT1 TTLL5 RABGAP1 NR4A1 RUNX1 PTPRA EGR1 NUP210

5.39e-0519915081270_UP
DrugCimetidine [51481-61-9]; Up 200; 15.8uM; HL60; HG-U133A

MGAM CENPT SREBF2 GON4L NR4A1 EGR1 TTLL4 BICRAL

5.39e-0519915081964_UP
Diseasevisual epilepsy (biomarker_via_orthology)

PDE4A SREBF2 SLC38A2 EGR1 PTPRZ1 PLD2

7.95e-06901546DOID:11832 (biomarker_via_orthology)
DiseaseMyeloid Leukemia, Chronic

PRTN3 ABL1 RUNX1 BRAF

1.53e-05291544C0023473
Diseaseobesity (implicated_via_orthology)

DCHS2 FAT4 MED13L GORASP2 ZFHX4 MED13 GNL3 TMEM18

1.83e-052151548DOID:9970 (implicated_via_orthology)
DiseaseHIV infection

AP3B1 PTPRA

2.71e-0521542EFO_0000764
Diseaseacute graft vs. host disease, donor genotype effect measurement

MDGA2 EYS TMEM131

6.06e-05151543EFO_0004599, EFO_0007892
Diseasetetranectin measurement

CDCP1 CLEC3B

8.09e-0531542EFO_0020957
Diseasemean corpuscular hemoglobin concentration

SP1 PIEZO1 RTTN GON4L PFAS RUNX1 CREB1 DMXL1 UBE2R2 MACF1 UBE3C MED17 LRIF1 MED13 MYB IMPG2

2.27e-04110515416EFO_0004528
DiseaseClear cell sarcoma of kidney

NUTM2E NUTM2B

4.00e-0461542C0334488
Diseaseretinitis pigmentosa

EYS DNAJC10

4.00e-0461542MONDO_0019200
DiseaseFailure to Thrive

ABL1 AP1B1

4.00e-0461542C0015544
DiseaseCystic kidney

TMEM67 FAT4

4.00e-0461542C0022679
DiseaseHeadache, fasting blood glucose measurement

AP3B1 UBE3C

5.59e-0471542EFO_0004465, HP_0002315
Diseaseprogressive supranuclear palsy

SP1 RUNX2 CD8B

5.63e-04311543MONDO_0019037
DiseasePolyarthritis, Juvenile, Rheumatoid Factor Positive

TTLL5 MEX3C CD8B EGR1 UBE3C

6.37e-041311545C4704862
DiseasePolyarthritis, Juvenile, Rheumatoid Factor Negative

TTLL5 MEX3C CD8B EGR1 UBE3C

6.37e-041311545C4552091
DiseaseJuvenile arthritis

TTLL5 MEX3C CD8B EGR1 UBE3C

6.37e-041311545C3495559
DiseaseJuvenile psoriatic arthritis

TTLL5 MEX3C CD8B EGR1 UBE3C

6.37e-041311545C3714758
DiseaseJuvenile-Onset Still Disease

TTLL5 MEX3C CD8B EGR1 UBE3C

7.29e-041351545C0087031
DiseaseNonsyndromic Deafness

ESPN BDP1 CD164 TECTA

8.69e-04811544C3711374
Diseaseosteoarthritis, knee, body mass index

B4GALNT4 NFAT5 TMEM18

1.28e-03411543EFO_0004340, EFO_0004616
DiseaseCystic Kidney Diseases

TMEM67 FAT4

1.44e-03111542C1691228
DiseaseProstatic Neoplasms

ZBTB20 RPN2 LMTK2 RUNX1 PYHIN1 NCOR1 DNAJC10 BRAF EGR1 MUC4

1.53e-0361615410C0033578
DiseaseMalignant neoplasm of prostate

ZBTB20 RPN2 LMTK2 RUNX1 PYHIN1 NCOR1 DNAJC10 BRAF EGR1 MUC4

1.53e-0361615410C0376358
DiseaseC-reactive protein measurement

NCOA6 SP3 DCHS2 ZBTB9 NCOR1 ZNF106 GYS2 PKD1 MACF1 TAF4 PLD2 BCAM NFAT5 GCN1 TMEM18

1.67e-03120615415EFO_0004458
Diseasehemoglobin A1 measurement

MGAM RC3H2 ZBTB38 PIEZO1 CD164 PTPRA MACF1 UBE3C YTHDF2

1.70e-035201549EFO_0007629
Diseaseresponse to diuretic, high density lipoprotein cholesterol measurement

RABGAP1 TRIP11

1.73e-03121542EFO_0004612, GO_0036270
DiseaseCarcinogenesis

ABL1 BRAF

2.03e-03131542C0596263
DiseaseArthritis, Psoriatic

RUNX2 NOD2

2.36e-03141542C0003872
Diseaseeosinophil measurement

HEXB PRTN3 TMEM131L TMEM131

2.51e-031081544EFO_0803540
Diseasebody weight

MGAM ZBTB38 RTTN GON4L MDGA2 RABGAP1 AP3B1 MEX3C SLC38A2 NCOR1 EYS USF3 EGR1 PKD1 TMEM18

2.55e-03126115415EFO_0004338
Diseaseplatelet storage pool deficiency (implicated_via_orthology)

AP3B1 LYST

2.72e-03151542DOID:2223 (implicated_via_orthology)
Diseaseendometriosis (biomarker_via_orthology)

RUNX1 EGR1

3.10e-03161542DOID:289 (biomarker_via_orthology)
Diseasecolorectal mucinous adenocarcinoma

ZBTB20 PTPRA

3.10e-03161542EFO_0009361
Diseaseautosomal recessive polycystic kidney disease (implicated_via_orthology)

TMEM67 PKD1

3.10e-03161542DOID:0110861 (implicated_via_orthology)
Diseaseserum gamma-glutamyl transferase measurement

SP3 LMTK2 GON4L ZNF804A NPTN EYS POM121 GYS2 PKD1 TAF4 GCN1 MED13

3.14e-0391415412EFO_0004532
Diseasefacial morphology measurement

DCHS2 FAT4 RUNX2 CPED1 ZNF804A ZNF106 EYS MRTFA

3.20e-034661548EFO_0007841
Diseasemean reticulocyte volume

SP1 SP3 ABCB7 PIEZO1 RTTN RUNX1 CPED1 PTPRA TMEM131L TAF4 MYB

3.25e-0379915411EFO_0010701
Diseasephosphatidylcholine 40:6 measurement

NOD2 PTPRA

3.50e-03171542EFO_0010389
Diseaseautosomal dominant intellectual developmental disorder (is_implicated_in)

RFX7 MED13

3.50e-03171542DOID:0060307 (is_implicated_in)
Diseasepulmonary surfactant-associated protein d measurement

NUTM2E ATP2C2

3.92e-03181542EFO_0020693
Diseaseloneliness measurement

ZNF804A CNTN6 MACF1 MBD5

4.12e-031241544EFO_0007865
DiseaseHETE measurement

ZBTB20 PIEZO1 CNTN6

4.21e-03621543EFO_0801166
Diseasepuberty onset measurement

NCOA6 SPEM3 NFAT5 TMEM18

4.24e-031251544EFO_0005677
Diseasehydrocephalus (implicated_via_orthology)

TMEM67 MBOAT7

4.37e-03191542DOID:10908 (implicated_via_orthology)
Diseasehair colour measurement

ZBTB38 PIEZO1 NRG2 REV3L RUNX2 TRIP11 LYST SLC38A2 MYB

5.14e-036151549EFO_0007822

Protein segments in the cluster

PeptideGeneStartEntry
SSSVSPLILSSNLPV

C2orf49

146

Q9BVC5
LPSSLSVFQNPTDVA

BRAF

131

P15056
LLPSPSVITTQSENI

BDP1

2561

A6H8Y1
TPSLASFDQPATIQT

CCDC187

356

A0A096LP49
QFQLLFPSTTPGIQS

CPED1

466

A4D0V7
LTQPAVALPTSLSLS

CCAR1

106

Q8IX12
LQPSTSLLPTLNRTF

CDCP1

111

Q9H5V8
QPLTPNQIVSTLFTS

ALG3

331

Q92685
QFAQSPNVTPIFTLS

GTPBP2

361

Q9BX10
AIFSTQRQSLPPVTT

GYS2

431

P54840
FPENQPVSSLVTTIT

FAT4

2576

Q6V0I7
SPNQTVEISLPLSTV

AP1B1

786

Q10567
TFTTLLQNIPSFAPV

ATAD2

876

Q6PL18
QTPSPLQELSAQSSV

AMIGO3

421

Q86WK7
TFPPATALALVSTIQ

DPH1

171

Q9BZG8
CPSLLPTQQSASLVS

SLC7A2

481

P52569
QLSRPLSQAVSFSTP

CAMSAP3

396

Q9P1Y5
SSPLSEQTSVPLLFA

DMXL1

2171

Q9Y485
LITLSTVFNLPSPLN

ATP2C2

746

O75185
TSAVIIAAPQNFTPS

AP3B1

1006

O00203
VTSCFSQPLPVSISN

RC3H2

1136

Q9HBD1
SLAQSPLKLFPSQAT

NR4A1

201

P22736
LDQVLTSPFNTTFPL

ANK2

2166

Q01484
QLLSPSSSIVPAFNT

AP1G1

761

O43747
LSNQLSASSTINPVP

RABGAP1

96

Q9Y3P9
LTFSSPVTNQAIAIP

NUP210

1766

Q8TEM1
VLVTTLPSSVAFTPQ

MUC16

4751

Q8WXI7
FTTALISNATPLPVT

MUC4

966

Q99102
VSQPTFINSVLPISA

COLQ

21

Q9Y215
TFPQILAPIIFSTSI

KIAA0100

411

Q14667
ILVFPTSSTIQVAPA

MED13L

1996

Q71F56
SPLQIPVSRSFSSTL

MAGEC1

196

O60732
PVSPSSSSTLLSLFQ

MAGEC1

236

O60732
LTPIFQRTDPISTQT

EYS

1246

Q5T1H1
FTEVQLSSVNPPSLS

GORASP2

231

Q9H8Y8
SSSTSASVQLPIFQP

LRIF1

86

Q5T3J3
ASTNATPVPITTTLF

MGAM2

2011

Q2M2H8
PNVTTLAPISNVTSA

CD164

31

Q04900
LAPISNVTSAPVTSL

CD164

36

Q04900
IVSPQFQEISLPTTS

KIAA0319L

411

Q8IZA0
FPTQQPNTTTLASRK

MGAM

821

O43451
LSPVSFSPVLAQSLE

MGRN1

336

O60291
STQLPNTAFNKTITP

KIAA2026

1161

Q5HYC2
PQLQAFLVPKSTTSS

KIAA2026

1316

Q5HYC2
VSVQPLNFDLSSPTS

ESPN

361

B1AK53
TQQPSLTPLSTIKAF

EGR1

281

P18146
VRSNFSLLTNVPVPS

PDE4A

191

P27815
PTLTLPQSLQSAFSG

DBX1

21

A6NMT0
LATQVPTFEITSPNS

NRG2

611

O14511
SLNIASPPSLILNTV

MACF1

2591

O94854
TPTPFTNAVQLLLTL

MBOAT7

96

Q96N66
QPSNQTTLPATLSIA

LAMP3

161

Q9UQV4
SPAEVFTLSVPNISL

LMTK2

101

Q8IWU2
TPPVNTRVLAFLSSV

GCN1

2086

Q92616
FTQTSPVADAPNILT

MYB

556

P10242
IISQPFPSLQLSISL

MED17

331

Q9NVC6
GSQVFLQPLSSTPVS

TEPSIN

386

Q96N21
PATSAIPFISENISQ

PTPRZ1

591

P23471
TSSVPLVLDSFLTPQ

OR2S2

76

Q9NQN1
SPANLSASVATVQLP

PRTN3

126

P24158
TLTLQTPSSPILCTQ

NFAT5

426

O94916
TNVLSSTFLSPQCSP

MYOCD

621

Q8IZQ8
IDVNISSSTVPPNLT

MDGA2

431

Q7Z553
NIASPPSLILNTVLS

MACF1

6466

Q9UPN3
LLQSQPSITLTSQPA

POU2F1

236

P14859
FLSPESPTNQTTVIV

DCHS2

2046

Q6V1P9
TLTFSNTSTPTFNIP

POM121B

521

A6NF01
SSISTPLPPNQITVF

NCOA6

1586

Q14686
PTLTFSNTSTPTFNI

POM121

936

Q96HA1
LPNVTFLPQNATTIS

MUC7

126

Q8TAX7
QLSVVDFLPTTAQPT

CD8B2

131

A6NJW9
IISTQTAIPATTPTF

IGSF10

1311

Q6WRI0
APQSQFLIPTSLSVS

BICRAL

396

Q6AI39
SNLPVNTSISSVQLP

CACNA2D4

196

Q7Z3S7
QLSVVDFLPTTAQPT

CD8B

131

P10966
TRSLNLTFATPLQPQ

CENPT

186

Q96BT3
AQSSPANFRITSPTV

PYHIN1

461

Q6K0P9
QTIPITTLLVNPTSF

GON4L

1176

Q3T8J9
QPSSTAFIPLISTRV

ABL1

996

P00519
SPIQIFTIQTRTPFS

CNTN6

626

Q9UQ52
ATSSAPTVTLVQLPN

CREB1

46

P16220
LPAFPTSSLLTQSQK

LYST

2106

Q99698
QSFTPQCSLIRSLTP

MAMLD1

471

Q13495
TVSSFLPQAPSRQIS

HOXC11

46

O43248
TAVNSTTQISPIPAL

MBD5

1106

Q9P267
ITIIDSPSFIVSPLN

GNL3

301

Q9BVP2
TSPSVLLNLQCPTTQ

SLC44A5

101

Q8NCS7
SPINIISSQAVYSPS

CA7

31

P43166
PSVVSLTPTTFNELV

DNAJC10

556

Q8IXB1
PINPTLNTTYSFLTT

HEXB

321

P07686
ASLPTVPVLSRTQNF

BCAM

426

P50895
TVPAVLSPNATLALT

PKD1

1026

P98161
LTSLSVAPTFSPNIT

PTPRA

56

P18433
SPNITLGPTYLTTVN

PTPRA

66

P18433
PQETQSAFSIPVSTL

NXF2

546

Q9GZY0
APQVLSSTSLPTNFS

TMEM67

306

Q5HYA8
LVLSTFPSTPLVTEQ

NUTM2B

176

A6NNL0
LVLSTFPSTPLVTEQ

NUTM2E

176

B1AL46
FTLTITVFTNPPQVA

RUNX1

146

Q01196
SFTLTITVFTNPPQV

RUNX2

196

Q13950
LGSTEFQPLVQSTTL

RTTN

1556

Q86VV8
FQPLVQSTTLLPEAS

RTTN

1561

Q86VV8
ATVTSALQPPVLSLT

TAF4

711

O00268
QFEPVLLPTSTTNFT

TMEM131L

331

A2VDJ0
LPNTSESFQPVSTVL

TMEM200A

331

Q86VY9
PSALINLSNFSSIKP

TAF12

6

Q16514
LQASPSPLTTVSLQD

PRR36

531

Q9H6K5
FQNSPSALVSTPVRT

NCOR1

2081

O75376
VSTPNLPQESLTSIL

SPATA31A7

571

Q8IWB4
LLLLSPPAATASQTQ

MEX3C

141

Q5U5Q3
LLPTPITQQASLTSL

PRRC1

166

Q96M27
APSLPQQLVIASQSS

TSC22D1

781

Q15714
QQLPAVSSLPSASSI

TSC22D1

816

Q15714
SSLLSQPNLVAPTSQ

MED13

1471

Q9UHV7
LSIDSLPSSSFTQPV

IMPG2

526

Q9BZV3
FPTQTLSLTPASSLV

SRCAP

1711

Q6ZRS2
ASSLVPTPAQTLSLA

SRCAP

1721

Q6ZRS2
LLPVNSVSAATLTPS

SP1

266

P08047
FSQPVQTTDSLPLTT

NPAP1

401

Q9NZP6
NTTPPSKTVILQSTF

NPAP1

826

Q9NZP6
TSPLTQLTLQASPLQ

MRTFA

481

Q969V6
PVTLFQPSVSSAAQV

SOX30

481

O94993
SPLQITPQTATVAFD

ABCB7

461

O75027
TSFLSLSQVSGPQLP

B4GALNT4

626

Q76KP1
NVLVSQFTPESFPLT

TECTA

76

O75443
QASSPPATFLNIQTT

TSACC

36

Q96A04
VSTPNLPQESLTSIL

SPATA31A3

571

Q5VYP0
VTFSNTLPRANTPSV

PLPPR4

411

Q7Z2D5
PLLNQSISPLSSSVL

ZFHX4

501

Q86UP3
SVISLLNEPNTFSPA

CDC34

126

P49427
SPTDPTSVQTLLFNL

NOD2

396

Q9HC29
TFQPLTQRLSESPVF

REV3L

391

O60673
VSTPNLPQESLTSIL

SPATA31A1

571

Q5TZJ5
ILTSQFPIPSLFATI

SPEM3

636

A0A1B0GUW6
VSTPNLPQESLTSIL

SPATA31A5

571

Q5VU36
RPPTVVSNTFTALIL

RPN2

536

P04844
CLFSLLTQVTTEPPT

CLEC3B

11

P05452
TINTTLTQPTALVPA

SLC38A2

256

Q96QD8
TQSSIPFKSQASVIP

STPG1

31

Q5TH74
FTSTPVSLSTGQLPN

SP3

506

Q02447
FTEPSQVLPFLTSSQ

WDR97

41

A6NE52
GPRLNFSTPTSTNIV

PFAS

91

O15067
QPSPVSNQSLLSESV

ZFAND6

86

Q6FIF0
PSVQRSFTQVTLPSF

SREBF2

86

Q12772
NPALTALTTPIQTAA

SREBF2

271

Q12772
APILATNTIPSATTA

SAP130

381

Q9H0E3
SNLSSALPFTTPANT

TMEM131

1811

Q92545
SPVLPVTLQCNLTSS

NPTN

161

Q9Y639
LSQTPSSAVTPVLNE

USF3

446

Q68DE3
SQPPSITSLSVNNLI

USF3

1231

Q68DE3
LTQILEPSTVFPSAN

RFX7

1186

Q2KHR2
FPISRPNLTFSTLTV

TRBV29-1

81

A0A5B7
TVSQPGLSTFTAQLP

ZBTB20

541

Q9HC78
IRSSPFQTPVQSSAS

ZBTB9

171

Q96C00
LNSSLFSSPVIPIRN

ZNF180

201

Q9UJW8
IISPQLSSASLLTPQ

TRIP11

1311

Q15643
TLPLTQYLLTTSSPT

ZGRF1

1556

Q86YA3
PLLVTSNSDQFLTTP

TAPT1

516

Q6NXT6
SVISLLNEPNTFSPA

UBE2R2

126

Q712K3
PNSTNLLPTEISQSL

PIEZO1

891

Q92508
TVNTLTNSPAIPLET

ZBTB38

621

Q8NAP3
VQSSSTPQSLPLLLF

nan

16

Q6ZS46
FSLPQKSLPVSLTAN

TTLL4

146

Q14679
LLPKSTSTANQLPFT

PLD2

581

O14939
PTGASLQITTSPTFQ

ZNF106

1171

Q9H2Y7
TPQSPFLNLNSTCLT

SLC36A4

486

Q6YBV0
SVSSFPVSIPAVLTQ

TMEM18

6

Q96B42
TFTPQNPLLNSLSVL

TMEM236

281

Q5W0B7
QPTILLNTVSASASP

TTLL5

931

Q6EMB2
ITSNIVASNSLPPAT

YTHDF2

216

Q9Y5A9
QTFLSQLPVSPASAS

UBE3C

346

Q15386
FLSQIPALTRTSLPQ

ZNF804A

1131

Q7Z570
SVQKSSAFPPNLLTS

NACA

146

E9PAV3