Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionsmall GTPase binding

IPO8 IPO7 NCF2 IQGAP1 CSE1L APPL2 GCC2 DAAM1

1.48e-04321958GO:0031267
GeneOntologyMolecularFunctionATP:ADP antiporter activity

SLC25A5 SLC25A6

2.22e-045952GO:0005471
GeneOntologyMolecularFunctioncytoskeleton-nuclear membrane anchor activity

SYNE1 SYNE2

2.22e-045952GO:0140444
GeneOntologyMolecularFunctionGTPase binding

IPO8 IPO7 NCF2 IQGAP1 CSE1L APPL2 GCC2 DAAM1

3.21e-04360958GO:0051020
GeneOntologyCellularComponentBLOC-2 complex

HPS3 HPS5

5.98e-053942GO:0031084
GeneOntologyCellularComponentgranulocyte macrophage colony-stimulating factor receptor complex

JAK2 CSF2RB

1.19e-044942GO:0030526
GeneOntologyCellularComponentsarcoplasmic reticulum

MTMR12 XDH RYR1 SYNE2

6.70e-0488944GO:0016529
GeneOntologyCellularComponentmicrotubule organizing center attachment site

SYNE1 SYNE2

1.07e-0311942GO:0034992
GeneOntologyCellularComponentmeiotic nuclear membrane microtubule tethering complex

SYNE1 SYNE2

1.07e-0311942GO:0034993
GeneOntologyCellularComponentnuclear membrane protein complex

SYNE1 SYNE2

1.07e-0311942GO:0106083
GeneOntologyCellularComponentnuclear membrane microtubule tethering complex

SYNE1 SYNE2

1.07e-0311942GO:0106094
HumanPhenoProximal lower limb amyotrophy

SYNE1 ANO5 SPG11 RYR1 SYNE2

1.20e-0720335HP:0008956
HumanPhenoAbnormality thigh musculature morphology

SYNE1 ANO5 SPG11 RYR1 SYNE2

1.57e-0721335HP:0001441
HumanPhenoProximal amyotrophy

SYNE1 ANO5 SPG11 RYR1 SYNE2

2.99e-0558335HP:0007126
HumanPhenoAbnormal pulse pressure

RYR1 ALB

4.07e-052332HP:0030850
HumanPhenoMuscle fiber atrophy

SYNE1 ANO5 SPG11 RYR1 SYNE2

6.04e-0567335HP:0100295
HumanPhenoProximal muscle weakness in upper limbs

SYNE1 ANO5 SPG11 RYR1 SYNE2

6.49e-0568335HP:0008997
HumanPhenoAbnormal calf musculature morphology

ANO5 SPG11 RYR1 KLHL9 SACS

8.00e-0571335HP:0001430
HumanPhenoLimb-girdle muscular dystrophy

SYNE1 ANO5 SYNE2

1.58e-0417333HP:0006785
HumanPhenoType 1 muscle fiber atrophy

SYNE1 RYR1 SYNE2

1.89e-0418333HP:0011807
DomainCse1

IPO8 IPO7 CSE1L

1.27e-073953IPR013713
DomainCse1

IPO8 IPO7 CSE1L

1.27e-073953PF08506
DomainSpectrin_repeat

SYNE1 SPTA1 KRT77 SYNE2

1.35e-0529954IPR002017
DomainSpectrin/alpha-actinin

SYNE1 SPTA1 KRT77 SYNE2

2.03e-0532954IPR018159
DomainSPEC

SYNE1 SPTA1 KRT77 SYNE2

2.03e-0532954SM00150
DomainIMPORTIN_B_NT

IPO8 IPO7 CSE1L

4.46e-0514953PS50166
DomainIBN_N

IPO8 IPO7 CSE1L

5.55e-0515953PF03810
DomainIBN_N

IPO8 IPO7 CSE1L

6.80e-0516953SM00913
DomainImportin-beta_N

IPO8 IPO7 CSE1L

8.23e-0517953IPR001494
DomainKASH

SYNE1 SYNE2

1.53e-044952PF10541
DomainKASH

SYNE1 SYNE2

1.53e-044952IPR012315
DomainKASH

SYNE1 SYNE2

1.53e-044952PS51049
DomainKASH

SYNE1 SYNE2

1.53e-044952SM01249
DomainSpectrin

SYNE1 SPTA1 SYNE2

2.10e-0423953PF00435
DomainAnoct_dimer

ANO1 ANO5

5.29e-047952PF16178
DomainAnoct_dimer

ANO1 ANO5

5.29e-047952IPR032394
DomainTMC

TMC4 TMC8

7.03e-048952PF07810
DomainTMC

TMC4 TMC8

7.03e-048952IPR012496
Domain-

RELCH IPO8 IPO7 CSE1L ELMO2 DAAM1

9.50e-042229561.25.10.10
DomainAnoctamin

ANO1 ANO5

1.12e-0310952PF04547
DomainAnoctamin

ANO1 ANO5

1.12e-0310952IPR007632
DomainPH_dom-like

MTMR12 JAK2 APPL2 ELMO2 DGKK OSBPL8 ARHGAP20 ARHGEF26

1.48e-03426958IPR011993
DomainGrpE_coiled_coil

KRT77 CNGA1

1.63e-0312952IPR013805
DomainMit_uncoupling

SLC25A5 SLC25A6

1.63e-0312952IPR002030
DomainARM-type_fold

RELCH IPO8 IPO7 CSE1L CEBPZ ELMO2 DAAM1

1.72e-03339957IPR016024
DomainARM-like

RELCH IPO8 IPO7 CSE1L ELMO2 DAAM1

2.56e-03270956IPR011989
DomainPH

APPL2 ELMO2 DGKK OSBPL8 ARHGAP20 ARHGEF26

2.96e-03278956SM00233
DomainPH_DOMAIN

APPL2 ELMO2 DGKK OSBPL8 ARHGAP20 ARHGEF26

3.02e-03279956PS50003
DomainPH_domain

APPL2 ELMO2 DGKK OSBPL8 ARHGAP20 ARHGEF26

3.07e-03280956IPR001849
Domain-

MTMR12 APPL2 ELMO2 DGKK OSBPL8 ARHGAP20 ARHGEF26

3.81e-033919572.30.29.30
DomainCH

SYNE1 IQGAP1 SYNE2

4.43e-0365953SM00033
DomainTetraspanin_CS

CD82 CD53

5.05e-0321952IPR018503
DomainCH

SYNE1 IQGAP1 SYNE2

5.46e-0370953PF00307
Domain-

SYNE1 IQGAP1 SYNE2

5.68e-03719531.10.418.10
DomainActinin_actin-bd_CS

SYNE1 SYNE2

6.04e-0323952IPR001589
DomainACTININ_2

SYNE1 SYNE2

6.04e-0323952PS00020
DomainACTININ_1

SYNE1 SYNE2

6.04e-0323952PS00019
DomainCH

SYNE1 IQGAP1 SYNE2

6.13e-0373953PS50021
DomainCH-domain

SYNE1 IQGAP1 SYNE2

6.61e-0375953IPR001715
DomainTM4_1

CD82 CD53

7.68e-0326952PS00421
Pubmed

A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.

IPO7 SYNE1 LRRC2 SUCLG2 RYR1 APPL2 ATG12 DPY30 SYNE2 TGS1

1.48e-06497981023414517
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

NEMP1 RELCH SPG11 KBTBD2 IQGAP1 TUBGCP6 KLHL9 DAAM1 ARHGAP20 HPS5

2.58e-06529981014621295
Pubmed

Multiple novel nesprin-1 and nesprin-2 variants act as versatile tissue-specific intracellular scaffolds.

SYNE1 SYNE2

7.86e-06298222768332
Pubmed

Xanthine Oxidase Activity in Type 2 Diabetes Mellitus Patients with and without Diabetic Peripheral Neuropathy.

XDH ALB

7.86e-06298227965983
Pubmed

Nesprins: a novel family of spectrin-repeat-containing proteins that localize to the nuclear membrane in multiple tissues.

SYNE1 SYNE2

7.86e-06298211792814
Pubmed

BioID screen of Salmonella type 3 secreted effectors reveals host factors involved in vacuole positioning and stability during infection.

HPS3 HPS5

7.86e-06298231611645
Pubmed

Nesprin-1 and nesprin-2 regulate endothelial cell shape and migration.

SYNE1 SYNE2

7.86e-06298224931616
Pubmed

PIMT Controls Insulin Synthesis and Secretion through PDX1.

PDX1 TGS1

7.86e-06298237175791
Pubmed

Syne-1 and Syne-2 play crucial roles in myonuclear anchorage and motor neuron innervation.

SYNE1 SYNE2

7.86e-06298217267447
Pubmed

Changes in the expression of the human adenine nucleotide translocase isoforms condition cellular metabolic/proliferative status.

SLC25A5 SLC25A6

7.86e-06298226842067
Pubmed

Nesprins: tissue-specific expression of epsilon and other short isoforms.

SYNE1 SYNE2

7.86e-06298224718612
Pubmed

Targeted ablation of nesprin 1 and nesprin 2 from murine myocardium results in cardiomyopathy, altered nuclear morphology and inhibition of the biomechanical gene response.

SYNE1 SYNE2

7.86e-06298224586179
Pubmed

Nesprin-1 and -2 are involved in the pathogenesis of Emery Dreifuss muscular dystrophy and are critical for nuclear envelope integrity.

SYNE1 SYNE2

7.86e-06298217761684
Pubmed

Nesprin-1-alpha2 associates with kinesin at myotube outer nuclear membranes, but is restricted to neuromuscular junction nuclei in adult muscle.

SYNE1 SYNE2

7.86e-06298231578382
Pubmed

Glucagon-like peptide 1 receptor agonist ameliorates the insulin resistance function of islet β cells via the activation of PDX-1/JAK signaling transduction in C57/BL6 mice with high-fat diet-induced diabetes.

PDX1 JAK2

7.86e-06298228290604
Pubmed

Kelch Domain of Gigaxonin Interacts with Intermediate Filament Proteins Affected in Giant Axonal Neuropathy.

SLC25A5 SLC25A6 SYNE1 SPTA1 CEBPZ SYNE2

1.56e-0518798626460568
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

TOB2 MTMR12 SYNE1 GCC2 HERC3 UBE3C SLC39A14 CLEC16A

2.06e-0540798812693553
Pubmed

Characterization of BLOC-2, a complex containing the Hermansky-Pudlak syndrome proteins HPS3, HPS5 and HPS6.

HPS3 HPS5

2.35e-05398215030569
Pubmed

Diabetes Susceptibility Genes Pdx1 and Clec16a Function in a Pathway Regulating Mitophagy in β-Cells.

PDX1 CLEC16A

2.35e-05398226085571
Pubmed

The Hermansky-Pudlak syndrome 3 (cocoa) protein is a component of the biogenesis of lysosome-related organelles complex-2 (BLOC-2).

HPS3 HPS5

2.35e-05398214718540
Pubmed

Growth factor pleiotropy is controlled by a receptor Tyr/Ser motif that acts as a binary switch.

JAK2 CSF2RB

2.35e-05398216437163
Pubmed

Syne-1, a dystrophin- and Klarsicht-related protein associated with synaptic nuclei at the neuromuscular junction.

SYNE1 SYNE2

2.35e-05398210878022
Pubmed

Three lysine residues in the common β chain of the interleukin-5 receptor are required for Janus kinase (JAK)-dependent receptor ubiquitination, endocytosis, and signaling.

JAK2 CSF2RB

2.35e-05398221965659
Pubmed

DOT1L O-GlcNAcylation promotes its protein stability and MLL-fusion leukemia cell proliferation.

UBE3C DOT1L

2.35e-05398234551297
Pubmed

The inner nuclear membrane protein Sun1 mediates the anchorage of Nesprin-2 to the nuclear envelope.

SYNE1 SYNE2

2.35e-05398216079285
Pubmed

The human mitochondrial ADP/ATP carriers: kinetic properties and biogenesis of wild-type and mutant proteins in the yeast S. cerevisiae.

SLC25A5 SLC25A6

2.35e-05398212450408
Pubmed

The nesprins are giant actin-binding proteins, orthologous to Drosophila melanogaster muscle protein MSP-300.

SYNE1 SYNE2

2.35e-05398212408964
Pubmed

Preferential utilization of Imp7/8 in nuclear import of Smads.

IPO8 IPO7

2.35e-05398218519565
Pubmed

The amino-terminal portion of the JAK2 protein kinase is necessary for binding and phosphorylation of the granulocyte-macrophage colony-stimulating factor receptor beta c chain.

JAK2 CSF2RB

2.35e-0539827775438
Pubmed

Convergence of signaling by interleukin-3, granulocyte-macrophage colony-stimulating factor, and mast cell growth factor on JAK2 tyrosine kinase.

JAK2 CSF2RB

2.35e-0539827527392
Pubmed

DNA sequences of two expressed nuclear genes for human mitochondrial ADP/ATP translocase.

SLC25A5 SLC25A6

2.35e-0539822541251
Pubmed

Distinct functional domains in nesprin-1alpha and nesprin-2beta bind directly to emerin and both interactions are disrupted in X-linked Emery-Dreifuss muscular dystrophy.

SYNE1 SYNE2

2.35e-05398217462627
Pubmed

NGS-based 100-gene panel of hypopigmentation identifies mutations in Chinese Hermansky-Pudlak syndrome patients.

HPS3 HPS5

2.35e-05398227593200
Pubmed

Two distinct genes for ADP/ATP translocase are expressed at the mRNA level in adult human liver.

SLC25A5 SLC25A6

2.35e-0539822829183
Pubmed

KIF2C promotes clear cell renal cell carcinoma progression via activating JAK2/STAT3 signaling pathway.

JAK2 KIF2C

2.35e-05398237863123
Pubmed

Ptf1a binds to and activates area III, a highly conserved region of the Pdx1 promoter that mediates early pancreas-wide Pdx1 expression.

PDX1 ALB

2.35e-05398217403901
Pubmed

Ph(-) myeloproliferative neoplasm red blood cells display deregulation of IQGAP1-Rho GTPase signaling depending on CALR/JAK2 status.

IQGAP1 JAK2

2.35e-05398227566291
Pubmed

Structures of FHOD1-Nesprin1/2 complexes reveal alternate binding modes for the FH3 domain of formins.

SYNE1 SYNE2

2.35e-05398233472039
Pubmed

Jak2V617F driven myeloproliferative neoplasm occurs independently of interleukin-3 receptor beta common signaling.

JAK2 CSF2RB

2.35e-05398226589916
Pubmed

Nesprins anchor kinesin-1 motors to the nucleus to drive nuclear distribution in muscle cells.

SYNE1 SYNE2

2.35e-05398225516977
Pubmed

Defining the human deubiquitinating enzyme interaction landscape.

IPO7 USP29 SUCLG2 IQGAP1 KLHL9 CSE1L GCC2 KRT77 DPY30 ALB STAMBPL1 RAD17

2.63e-051005981219615732
Pubmed

BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.

IPO7 SLC25A5 SRPRA HM13 IQGAP1 RABL6 CSE1L OSBPL8 ARHGEF26 KIF2C

3.21e-05708981039231216
Pubmed

An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.

ARHGAP17 SRPRA SPG11 HM13 ZWINT KLHL9 CEBPZ OSBPL8 UBE3C TGS1

4.30e-05733981034672954
Pubmed

Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

NEMP1 SYNE1 SYNE2 OSBPL8 HPS5 CLEC16A

4.40e-0522598612168954
Pubmed

Identification of a novel function of the clathrin-coated structure at the plasma membrane in facilitating GM-CSF receptor-mediated activation of JAK2.

JAK2 CSF2RB

4.70e-05498222935703
Pubmed

Differential Expression of ADP/ATP Carriers as a Biomarker of Metabolic Remodeling and Survival in Kidney Cancers.

SLC25A5 SLC25A6

4.70e-05498233396658
Pubmed

Defective development of the gall bladder and cystic duct in Lgr4- hypomorphic mice.

PDX1 ALB

4.70e-05498219301403
Pubmed

SUN1 interacts with nuclear lamin A and cytoplasmic nesprins to provide a physical connection between the nuclear lamina and the cytoskeleton.

SYNE1 SYNE2

4.70e-05498216648470
Pubmed

Gamma-glutamyl transpeptidase, an ecto-enzyme regulator of intracellular redox potential, is a component of TM4 signal transduction complexes.

CD82 CD53

4.70e-0549829862348
Pubmed

Simultaneous activation of JAK1 and JAK2 confers IL-3 independent growth on Ba/F3 pro-B cells.

JAK2 CSF2RB

4.70e-05498215988755
Pubmed

LINC complexes mediate the positioning of cone photoreceptor nuclei in mouse retina.

SYNE1 SYNE2

4.70e-05498223071752
Pubmed

SH2-Containing protein tyrosine phosphatase-1 (SHP-1) association with Jak2 in UT-7/Epo cells.

JAK2 CSF2RB

4.70e-05498210772872
Pubmed

Nesprins, but not sun proteins, switch isoforms at the nuclear envelope during muscle development.

SYNE1 SYNE2

4.70e-05498220108321
Pubmed

JAK2 and JAK1 constitutively associate with an interleukin-5 (IL-5) receptor alpha and betac subunit, respectively, and are activated upon IL-5 stimulation.

JAK2 CSF2RB

4.70e-0549829516124
Pubmed

HPS6 interacts with dynactin p150Glued to mediate retrograde trafficking and maturation of lysosomes.

HPS3 HPS5

4.70e-05498225189619
Pubmed

Platelet alpha granules in BLOC-2 and BLOC-3 subtypes of Hermansky-Pudlak syndrome.

HPS3 HPS5

4.70e-05498217365864
Pubmed

Molecular cloning of a second subunit of the receptor for human granulocyte-macrophage colony-stimulating factor (GM-CSF): reconstitution of a high-affinity GM-CSF receptor.

JAK2 CSF2RB

4.70e-0549821702217
Pubmed

Nesprin-2 interacts with meckelin and mediates ciliogenesis via remodelling of the actin cytoskeleton.

SYNE1 SYNE2

4.70e-05498219596800
Pubmed

Conformational Changes in the GM-CSF Receptor Suggest a Molecular Mechanism for Affinity Conversion and Receptor Signaling.

JAK2 CSF2RB

4.70e-05498227396825
Pubmed

Functional cross-talk between cytokine receptors revealed by activating mutations in the extracellular domain of the beta-subunit of the GM-CSF receptor.

JAK2 CSF2RB

4.70e-05498212488507
Pubmed

Outer nuclear membrane protein Kuduk modulates the LINC complex and nuclear envelope architecture.

SYNE1 SYNE2

4.70e-05498228716842
Pubmed

Proteomic analysis and identification of cellular interactors of the giant ubiquitin ligase HERC2.

HM13 HPS3 GCC2 HPS5 CDC25C

4.78e-0513998525476789
Pubmed

A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.

IPO8 IPO7 SLC25A6 SRPRA SUCLG2 CTSA IQGAP1 CSE1L CEBPZ DPY30 SYNE2 OSBPL8 UBE3C SLC39A14

5.16e-051440981430833792
Pubmed

A High-Density Human Mitochondrial Proximity Interaction Network.

NEMP1 IPO8 SLC25A5 SLC25A6 SYNE1 SRPRA HM13 SUCLG2 KRT77 SYNE2 OSBPL8 UBE3C SLC39A14 KIF2C

7.75e-051496981432877691
Pubmed

A novel class of RanGTP binding proteins.

IPO8 IPO7

7.82e-0559829214382
Pubmed

Identification of tumor-associated antigens in chronic lymphocytic leukemia by SEREX.

GCC2 TGS1

7.82e-05598212200376
Pubmed

Structural requirements for the assembly of LINC complexes and their function in cellular mechanical stiffness.

SYNE1 SYNE2

7.82e-05598218396275
Pubmed

LINC complexes form by binding of three KASH peptides to domain interfaces of trimeric SUN proteins.

SYNE1 SYNE2

7.82e-05598222632968
Pubmed

Granulocyte-macrophage colony-stimulating factor stimulates JAK2 signaling pathway and rapidly activates p93fes, STAT1 p91, and STAT3 p92 in polymorphonuclear leukocytes.

JAK2 CSF2RB

7.82e-0559828631962
Pubmed

Supramolecular complexes of MHC class I, MHC class II, CD20, and tetraspan molecules (CD53, CD81, and CD82) at the surface of a B cell line JY.

CD82 CD53

7.82e-0559828816400
Pubmed

Reactive-site-centric chemoproteomics identifies a distinct class of deubiquitinase enzymes.

RELCH CSE1L KRT77 ALB

9.62e-058498429563501
Pubmed

Deubiquitinating enzyme PSMD14 promotes tumor metastasis through stabilizing SNAIL in human esophageal squamous cell carcinoma.

IPO8 IPO7 SLC25A5 SLC25A6 CSE1L ELMO2 ALB

1.09e-0438398729331416
Pubmed

Defining the membrane proteome of NK cells.

ENDOD1 IPO7 SLC25A5 HM13 CTSA TUBGCP6 CSE1L GCC2 OSBPL8 STAMBPL1 DAAM1 KIF2C

1.11e-041168981219946888
Pubmed

The structure of the GM-CSF receptor complex reveals a distinct mode of cytokine receptor activation.

JAK2 CSF2RB

1.17e-04698218692472
Pubmed

Melanoregulin, product of the dsu locus, links the BLOC-pathway and OA1 in organelle biogenesis.

HPS3 HPS5

1.17e-04698222984402
Pubmed

The HIV-1 viral protein R induces apoptosis via a direct effect on the mitochondrial permeability transition pore.

SLC25A5 SLC25A6

1.17e-04698210620603
Pubmed

Identification and characterization of TMEM16E and TMEM16F genes in silico.

ANO1 ANO5

1.17e-04698215067359
Pubmed

Structural Analysis of Different LINC Complexes Reveals Distinct Binding Modes.

SYNE1 SYNE2

1.17e-04698233058875
Pubmed

TorsinA binds the KASH domain of nesprins and participates in linkage between nuclear envelope and cytoskeleton.

SYNE1 SYNE2

1.17e-04698218827015
Pubmed

A bipotential precursor population for pancreas and liver within the embryonic endoderm.

PDX1 ALB

1.17e-04698211222142
Pubmed

HIV-1 Tat depresses DNA-PK(CS) expression and DNA repair, and sensitizes cells to ionizing radiation.

CDC25C KIF2C

1.17e-04698216751065
Pubmed

Regulation of insulin secretion by SIRT4, a mitochondrial ADP-ribosyltransferase.

SLC25A5 SLC25A6

1.17e-04698217715127
Pubmed

Identifying biological pathways that underlie primordial short stature using network analysis.

IPO7 SLC25A5 SLC25A6 SYNE1 IQGAP1 CSE1L SACS CEBPZ KRT77 SYNE2 ALB

1.48e-041024981124711643
Pubmed

Signal recognition particle protein 19 is imported into the nucleus by importin 8 (RanBP8) and transportin.

IPO8 IPO7

1.64e-04798211682607
Pubmed

Expression of leucine-rich repeat kinase 2 (LRRK2) inhibits the processing of uMtCK to induce cell death in a cell culture model system.

SLC25A5 SLC25A6

1.64e-04798221370995
Pubmed

ANOs 3-7 in the anoctamin/Tmem16 Cl- channel family are intracellular proteins.

ANO1 ANO5

1.64e-04798222075693
Pubmed

Transmembrane-4 superfamily proteins CD81 (TAPA-1), CD82, CD63, and CD53 specifically associated with integrin alpha 4 beta 1 (CD49d/CD29).

CD82 CD53

1.64e-0479828757325
Pubmed

An atlas of genetic influences on human blood metabolites.

SLC16A9 ARHGAP17 TMC4 SUCLG2 HPS5

2.08e-0419098524816252
Pubmed

Characterization of the transmembrane channel-like (TMC) gene family: functional clues from hearing loss and epidermodysplasia verruciformis.

TMC4 TMC8

2.18e-04898212906855
Pubmed

Different thresholds of fibroblast growth factors pattern the ventral foregut into liver and lung.

PDX1 ALB

2.18e-04898215576401
Pubmed

Expression and function of epithelial anoctamins.

ANO1 ANO5

2.18e-04898220056604
Pubmed

TMC and EVER genes belong to a larger novel family, the TMC gene family encoding transmembrane proteins.

TMC4 TMC8

2.18e-04898212812529
Pubmed

TSPO ligands stimulate ZnPPIX transport and ROS accumulation leading to the inhibition of P. falciparum growth in human blood.

SLC25A5 SLC25A6

2.18e-04898227641616
Pubmed

Anoctamins are a family of Ca2+-activated Cl- channels.

ANO1 ANO5

2.18e-04898222946059
Pubmed

Importin 8 mediates m7G cap-sensitive nuclear import of the eukaryotic translation initiation factor eIF4E.

IPO8 IPO7

2.18e-04898227114554
Pubmed

E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.

NEMP1 SLC25A5 SRPRA RYR1 IGSF10 JAK2 KCNS2 ALB ARHGAP20

2.39e-0473698929676528
Pubmed

LukS-PV inhibits hepatocellular carcinoma cells migration by downregulating HDAC6 expression.

SLC25A5 SLC25A6 SRPRA IQGAP1 CSE1L KRT77 OSBPL8 ALB

2.41e-0458098835676659
Pubmed

Suppression of DDX39B sensitizes ovarian cancer cells to DNA-damaging chemotherapeutic agents via destabilizing BRCA1 mRNA.

HM13 IQGAP1 KRT77 ALB

2.45e-0410798432989256
Pubmed

Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.

IPO8 IPO7 SLC25A6 SYNE1 SRPRA SPG11 HM13 TUBGCP6 SACS CEBPZ SYNE2 OSBPL8 DAAM1

2.77e-041487981333957083
Pubmed

The kinase LRRK2 is a regulator of the transcription factor NFAT that modulates the severity of inflammatory bowel disease.

IQGAP1 CSE1L

2.79e-04998221983832
GeneFamilyBiogenesis of lysosomal organelles complex 2

HPS3 HPS5

4.30e-0536921038
GeneFamilySpectrin repeat containing nuclear envelope family

SYNE1 SYNE2

8.57e-0546921252
GeneFamilyTransmembrane channel likes

TMC4 TMC8

3.96e-0486921135
GeneFamilyAnoctamins

ANO1 ANO5

6.33e-0410692865
GeneFamilyArmadillo repeat containing|Importins

IPO8 IPO7

2.11e-0318692596
CoexpressionGSE33292_WT_VS_TCF1_KO_DN3_THYMOCYTE_DN

NEMP1 ZWINT CSE1L SACS SLC39A14 CDC25C KIF2C

1.01e-05199987M9422
CoexpressionMURARO_PANCREAS_BETA_CELL

ENDOD1 IPO7 SLC16A9 PDX1 SRPRA ANO5 APPL2 ELMO2 GCC2 SYNE2 OSBPL8 UBE3C SLC39A14 RAD17

1.13e-059469814M39169
CoexpressionNAKAYA_PBMC_FLUARIX_FLUVIRIN_AGE_18_50YO_3DY_UP

MTMR12 IPO8 IPO7 ACER3 CTSA NLRC4 HPS3 IQGAP1 DPY30 CD53 HPS5

2.23e-056259811M41067
ToppCellPCW_05-06-Hematologic_Myeloid-Hem_Myeloid_monocytic-im_myeloid_progenitor2_(3)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

NCF2 RYR1 TLR10 CSF2RB TMC8 CD53

3.54e-06188976f4d11d06be46f13adbf36d94bc2bdcd14d0bfa75
ToppCellControl-B_memory-3|Control / disease group and sub_cluster of B and Plasma cells(res = 0.5)

TOB2 CTSA TLR10 CD82 CD53 DAAM1

4.63e-06197976b86385c6c1d52ef4e3d855004d77afab61556978
ToppCellPCW_07-8.5-Hematologic_Myeloid-Hem_Myeloid_dendritic|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

NCF2 RYR1 TLR10 CSF2RB TMC8 CD53

4.77e-061989761d242fbe4ae3628103f6b6f910a7641bb1b75266
ToppCellControl-B_memory-6|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)

TLR10 WASH4P DGKK DAAM1 SERPIND1

7.71e-061249753e987915026f503e8d072a837b6e7a34252e5c63
ToppCellPND07-Immune-Immune_Myeloid-Granulocytic-Basophil|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SYNE1 NCF2 JAK2 CSF2RB CD53

3.53e-05170975bca78719c17355772ad6c53ee75e459faf1d089f
ToppCellPND07-Immune-Immune_Myeloid-Granulocytic-Basophil-Basophil_mature|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SYNE1 NCF2 JAK2 CSF2RB CD53

3.53e-0517097540d863554ec98ae43f76511c1112859688846613
ToppCellfacs|World / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IPO7 CTSA IQGAP1 KLHL9 PCDHGC3

3.74e-05172975a2d0a64ebf09d219a07d6bbad1056bad6d46b9be
ToppCellfacs-Marrow-Granulocytes-3m-Myeloid-macrophage|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACER3 RYR1 DAAM1 SLC39A14 CLEC16A

3.74e-051729757fb31ccbcd0204c3612986a6bc20d57ed6825e9c
ToppCellfacs-Marrow-Granulocytes-3m-Myeloid-CD4+_macrophage|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACER3 RYR1 DAAM1 SLC39A14 CLEC16A

3.74e-051729752a4614b3d25e8c6b095e6992d8ca35371dcdb5e1
ToppCellfacs|World / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IQGAP1 ZWINT KLHL9 ARHGAP20 PCDHGC3

4.06e-0517597553e96956019f984decc1c81376ebc88fbf3c4d40
ToppCellfacs-Lung-EPCAM-3m-Myeloid|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NCF2 RYR1 JAK2 CSF2RB CD53

4.40e-0517897501c90c3952220cc4d6a7ed9c4d575fe4f2f80fd1
ToppCell3'-GW_trimst-1.5-LargeIntestine-Hematopoietic|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

NCF2 RYR1 TLR10 TMC8 CD53

4.52e-05179975716856b2c7c660bf5ce00e63efeda6ed121f2baa
ToppCelldroplet-Lung-1m-Hematologic-myeloid|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

NCF2 CTSA IQGAP1 CSF2RB CD53

4.52e-051799756d2458a887047b5c20389f08345ff5aac7c683e6
ToppCellmetastatic_Lymph_Node-B_lymphocytes-GC_B_cells_in_the_LZ|metastatic_Lymph_Node / Location, Cell class and cell subclass

SLC25A5 TLR10 SYNE2 CD53 DAAM1

5.02e-0518397530db83f600e2c4ad3af68a8a946673f4352a2807
ToppCellfacs-Limb_Muscle-ForelimbandHindlimb|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TOB2 IPO7 CSE1L DAAM1 SLC39A14

5.28e-05185975eb7d3c1363d5fedc611f9c1a91ea823de251355e
ToppCellPCW_05-06-Hematologic_Myeloid-Hem_Myeloid_monocytic-im_myeloid_progenitor3_(13)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

NCF2 RYR1 TLR10 TMC8 CD53

5.42e-051869756575ec6a626cdea169ffd185d47828dfaa29475d
ToppCellPCW_05-06-Hematologic_Myeloid-Hem_Myeloid_macrophage-im_immature_macrophage2_(0)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

NCF2 RYR1 TLR10 TMC8 CD53

5.56e-05187975bde6b90955423eab6a91a0abe75d0a95a1f5330a
ToppCellILEUM-non-inflamed-(1)_T_cell-(1)_T_(gd)|(1)_T_cell / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

SLC25A5 ANO5 CTSA IGSF10 KCNS2

5.56e-05187975e5713a7bda53d1d5178ab4e0dbadc2292b6005bc
ToppCellPCW_07-8.5-Hematologic_Myeloid-Hem_Myeloid_dendritic-im_migrating_dendritic_(5)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

RYR1 TLR10 CSF2RB TMC8 CD53

5.70e-051889758fc15c8b78fdd1a578e34325011bc5a87a8aab31
ToppCellPCW_07-8.5-Hematologic_Myeloid-Hem_Myeloid_monocytic-im_myeloid_progenitor2_(3)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

NCF2 RYR1 CSF2RB TMC8 CD53

5.99e-05190975081b7bc07b6e5685e8a91b9ae6c1141623723700
ToppCellPCW_07-8.5-Hematologic_Myeloid-Hem_Myeloid_macrophage-im_immature_macrophage2_(0)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

NCF2 RYR1 CSF2RB TMC8 CD53

5.99e-05190975912aa106581d1ed7e147c92f9a367e8e6b04052b
ToppCell5'-Airway_Nasal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.1.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SLC25A5 ANO1 RYR1 ZWINT KIF2C

6.15e-051919750f9443da0f73d07456142fae08b2dc92a5b7b592
ToppCellPCW_07-8.5-Hematologic_Myeloid-Hem_Myeloid_macrophage|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

NCF2 RYR1 CSF2RB TMC8 CD53

6.15e-05191975bce138f067b8962ecef1ddec6511a3f142d81d78
ToppCellPCW_13-14-Hematologic_Myeloid-Hem_Myeloid_monocytic-im_proliferating_myeloid_(8)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

NCF2 RYR1 TLR10 CSF2RB CD53

6.30e-05192975b204ef6e05170855259b902829a1700094eb9159
ToppCellPCW_07-8.5-Hematologic_Myeloid-Hem_Myeloid_macrophage-im_immature_macrophage1_(2)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

NCF2 RYR1 CSF2RB TMC8 CD53

6.30e-051929754e3deefd30adb7bf1eba294610eed3d077aa9418
ToppCellPCW_07-8.5-Hematologic_ErythroMegGranulo-Hem_Granulocytic-im_neutrophils_(9)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

NCF2 NLRC4 TLR10 TMC8 CD53

6.46e-05193975c9e3fefa8d68d0e2b954f85ce37813185ff98d84
ToppCellPCW_13-14-Hematologic_ErythroMegGranulo-Hem_Granulocytic-im_neutrophils_(9)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

NCF2 NLRC4 CSF2RB TMC8 CD53

6.46e-05193975888b11d7d66970931d1c33bea714659ca3cfe149
ToppCellnormal_Lymph_Node-B_lymphocytes-GC_B_cells_in_the_DZ|normal_Lymph_Node / Location, Cell class and cell subclass

SLC25A5 ZWINT DAAM1 CDC25C KIF2C

6.46e-051939755ce93860bc60ce6ecfed3a3d985f84e28781eec1
ToppCellPBMC-Control-Myeloid-cDC-cDC-cDC_3|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ACER3 RYR1 TLR10 JAK2 HPS5

6.61e-05194975b16ed97eb6b7b7a220e943474c0d85c141b6e3a5
ToppCellPCW_07-8.5-Hematologic_Myeloid|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

NCF2 RYR1 CSF2RB TMC8 CD53

6.61e-05194975260649f5c4aeaa9cbf5ed5ae5e9f293d75bb0457
ToppCell3'-Child04-06-SmallIntestine-Hematopoietic-B_cells-LZ_GC_cell|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TLR10 IGSF10 SYNE2 CD53 DAAM1

6.78e-05195975cccc9c70bb8f6df8c6ab94534c17475af1d3e224
ToppCellControl-B_memory-3|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)

TOB2 TLR10 CD82 CD53 DAAM1

6.78e-05195975135234f068da3e8db7213b53c09ed6d1d0cdc351
ToppCellCOVID-19-kidney-Proliferating_T_cell|kidney / Disease (COVID-19 only), tissue and cell type

SPTA1 TMC8 CD53 CDC25C KIF2C

6.78e-051959757e05e56f8d0a7a052830c7db12b10dace7d10760
ToppCellPCW_10-12-Hematologic_Myeloid-Hem_Myeloid_monocytic-im_myeloid_progenitor3_(13)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

NCF2 RYR1 TLR10 TMC8 CD53

6.78e-05195975c707885d092aedbbe14f51f7de4a5911c9214289
ToppCellBLOOD--(2)_B_cell-(2)_Memory_B_cells|(2)_B_cell / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

SLC25A6 CTSA TLR10 CD82 DAAM1

6.78e-05195975c25391931659881d4104b06cf07cb44efa635e39
ToppCellSmart-start-Cell-Wel_seq-Neoplastic-Differentiated-like-AC-like-AC-like_Prolif-C|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

SLC25A6 CD82 CDC25C PCDHGC3 KIF2C

6.78e-05195975bda3ca3d26afd06c226bc6fd1d8fd85a0e4fb52b
ToppCellLPS_anti-TNF-Mesenchymal_fibroblastic-Fibroblasts-Activated_MatrixFB|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

SYNE1 OGN IGSF10 SLC39A14 ARHGAP20

7.11e-05197975fdb92985f7df0c280b87d3e43c2394e70786a2c7
ToppCellBL|World / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

NCF2 IQGAP1 CSF2RB CD53 OSBPL8

7.11e-051979751acf0191fa0a25cd20bfd9ea7bf727a1555986a1
ToppCellPBMC-Control-Lymphocyte-T/NK-Other_T|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

SYNE1 ZWINT SYNE2 CDC25C KIF2C

7.28e-0519897580b105a7c7d00ea3b5e586831fbb755bd84f9d1a
ToppCellPBMC-Control-Lymphocyte-T/NK-Other_T|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

SYNE1 ZWINT SYNE2 CDC25C KIF2C

7.28e-05198975c73e906d2d12d6eba0e606958be16e63a2292cd0
ToppCell3'-GW_trimst-1-SmallIntestine-Neuronal-neuron_precursor-cycling_neuroblast|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

NPY2R ZWINT SYT14 CDC25C KIF2C

7.28e-051989752ee8ac82ef1b8ebabc8dd824211bbb471f2af8ac
ToppCellSevere-B_intermediate-6|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)

NCF2 TLR10 CD82 SACS SNX8

7.28e-051989758402421dc060926e968efe39a4e907f1e8ae5b1f
ToppCellParenchyma_Control_(B.)-Immune-TX-MoAM-3|Parenchyma_Control_(B.) / Sample group, Lineage and Cell type

NCF2 HM13 CTSA SNX8 CD53

7.46e-051999751ce46d9edabb3252f940a5143dd3f2404422d185
ToppCellMild/Remission-B_memory-3|Mild/Remission / disease group and sub_cluster of B and Plasma cells(res = 0.5)

TOB2 TLR10 CD82 CD53 DAAM1

7.46e-05199975493d043beef70b60338cc199db82592cdc6e635d
ToppCell(09)_Interm._secr.>cil.-(2)_GFP_FOXI1|(09)_Interm._secr.>cil. / shred by cell type by condition

IQGAP1 GCC2 SYNE2 OSBPL8 HPS5

7.46e-05199975fc680f85ebd3bab4c72876a19a461b0afb5f51ce
ToppCellPBMC-Mild-Lymphocyte-T/NK-Other_T|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)

SYNE1 ZWINT SYNE2 CDC25C KIF2C

7.46e-05199975101f78fe6dd1bf9e2e4dd5ad8a970312b3540927
ToppCellPBMC-Mild-Lymphocyte-T/NK-Other_T|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

SYNE1 ZWINT SYNE2 CDC25C KIF2C

7.46e-05199975e0fcec796afe75e42467ca86355b9fc5aa9ae0a1
ToppCell(03)_KRT6B+-(2)_GFP_FOXI1|(03)_KRT6B+ / shred by cell type by condition

SLC25A5 GCC2 SYNE2 OSBPL8 HPS5

7.46e-05199975c425e7975f492ed5cfcca022248adb627e1d27d4
ToppCell(05)_Secretory-(2)_GFP_FOXI1|(05)_Secretory / shred by cell type by condition

IQGAP1 GCC2 SYNE2 OSBPL8 HPS5

7.46e-05199975d72d87e1e530ed894c0ad5e7b5b2b1d6b59fa098
ToppCellLPS_IL1RA-Mesenchymal_fibroblastic-Fibroblasts-Activated_MatrixFB|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

SYNE1 IGSF10 JAK2 CD82 SLC39A14

7.46e-051999758b86c69aaf60feff53aa782559cfece7342a23de
ToppCellControl_saline-Mesenchymal_fibroblastic|Control_saline / Treatment groups by lineage, cell group, cell type

SYNE1 OGN IGSF10 STAMBPL1 ARHGAP20

7.64e-0520097564ae5cf6cb4fc94cf1052abd82648f6b8e6445fe
ToppCellmLN-Macrophage-LYVE1_Macrophage|Macrophage / Region, Cell class and subclass

ACER3 SRPRA SPG11 HM13 IQGAP1

7.64e-05200975e3c15e0e1c2602b0cc9ab8cc50c978d265350c94
ToppCellControl_saline-Mesenchymal_fibroblastic-Fibroblasts|Control_saline / Treatment groups by lineage, cell group, cell type

SYNE1 OGN IGSF10 STAMBPL1 ARHGAP20

7.64e-05200975a1fc74c1b27e104895910bc7cdce7ba33d30df7e
ToppCellControl_saline-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB|Control_saline / Treatment groups by lineage, cell group, cell type

SYNE1 OGN IGSF10 STAMBPL1 ARHGAP20

7.64e-05200975bd8cf33502adea320e91ca2af14e1911d88ad374
ToppCellLPS-antiTNF-Unknown-Endothelial|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ZWINT TLR10 CDC25C KIF2C

1.87e-04130974615c233c7c2600c1c2bc5cf5b1c501fc474564ef
ToppCellfrontal_cortex-Neuronal-glutamatergic_neuron-L2/3_IT-L2/3_IT_ALM_Sla|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

CLXN RYR1 GREB1L KRT77

1.99e-04132974ddebc0b233fdbb73ceb70187945bbed8fd273f2a
ToppCellLPS-IL1RA-Lymphocytic_NKT-iNKT/MAIT-Erythroid|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

MAGEE1 DGKK TMC8 CNGA1

2.04e-041339742ec3490cbf60152c3cece95eb566d749c9666517
ToppCellTCGA-Bladder-Solid_Tissue_Normal-Urothelial_normal_tissue-Urothelial_normal_tissue-2|TCGA-Bladder / Sample_Type by Project: Shred V9

LRRC2 OGN IGSF10 ARHGAP20

2.55e-041419741baa054c2ae3b446d1954244b7fbf8af824ef345
ToppCellPND01-Immune-Immune_Myeloid-Granulocytic|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SYNE1 NCF2 CSF2RB CD53

3.07e-0414897474f1f9d1a53dc1a09cb6a504cbbdc7496c5b6879
ToppCellPND10-Immune-Immune_Myeloid-Granulocytic|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SYNE1 NCF2 CSF2RB CD53

3.15e-04149974c9334f319a0c943268e54b6f0c9446736172c3a9
ToppCelldroplet-Fat-Scat-21m-Myeloid-monocyte|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACER3 NCF2 RYR1 CD53

3.23e-04150974b6e5e04aaf1c5265ac07581868d3159f9292a84c
ToppCellFrontal_cortex-Neuronal-Inhibitory-iN2(Gad1Gad2)-Synpr-Inhibitory_Neuron.Gad1Gad2-Chat.Synpr-Slc5a7_(Cholinergic_cortical__interneurons)-|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

NPY2R MAGEB5 TMC8

3.35e-0462973d63e8417192ebe5d44f0868c5991d28c83bfd75d
ToppCellFrontal_cortex-Neuronal-Inhibitory-iN2(Gad1Gad2)-Synpr-Inhibitory_Neuron.Gad1Gad2-Chat.Synpr-Slc5a7_(Cholinergic_cortical__interneurons)|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

NPY2R MAGEB5 TMC8

3.35e-0462973faf2f54e6ddb34f342ce18470fb44b3a5b1d4139
ToppCelldroplet-Marrow-BM_(NON-STC)-30m-Lymphocytic-NK_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CTSA RYR1 CD53 ARHGEF26

3.40e-0415297482a493ffb2f1704cd6f68a82d970fe12f537d20e
ToppCellfacs-Liver-Non-hepatocytes-3m-Myeloid-Kupffer_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NLRC4 GREB1L STAMBPL1 MGAT4C

3.40e-04152974b61d2f6ee819c8dd4b4b601a8bc8388b1983de58
ToppCellControl-Myeloid-Neutrophils|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

XDH NCF2 CSF2RB CD53

3.48e-04153974c33d63b2d1a220bc428e776b157b23faa43ea8ca
ToppCellControl-Myeloid-Neutrophils-Neutrophils|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

XDH NCF2 CSF2RB CD53

3.48e-04153974e3630f2b10f33092a3b6a63dba3a39fbdecbc7bd
ToppCellPND07-Immune-Immune_Myeloid-Granulocytic|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SYNE1 NCF2 CSF2RB CD53

3.57e-04154974f92d83c5f8b532fe5624f1cd352632f543d96ea9
ToppCellfacs-Brain_Myeloid-Cortex_-18m-Myeloid-macrophage|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

XDH NLRC4 RYR1 IQGAP1

3.75e-041569742ba838bc864c2c1767bcab7bb4d790af96b91387
ToppCellCOVID-19_Moderate-multiplets|World / disease group, cell group and cell class

SYNE1 SYNE2 TMC8 ARHGAP20

3.75e-04156974afdc025fa75e7926b1cc182c4a33654a2186abb1
ToppCellPND14-Immune-Immune_Myeloid-DC-cDC2-cDC2_prolif|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SLC25A5 CSE1L CSF2RB SYT14

3.75e-041569748349604bd801e20d33770f7d8243598c3756302b
ToppCelldroplet-Liver-Hepatocytes-24m-Myeloid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC16A9 NCF2 IQGAP1 CSF2RB

3.84e-04157974ec433d2fe827abdb647be4176c231b7052482b6f
ToppCellE15.5-Hematopoietic|E15.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

SPTA1 NCF2 CSF2RB CD53

3.84e-041579746315aef4b9bf673069d43a730d4e940011509ac1
ToppCellfacs-Heart-Unknown-3m-Myeloid-monocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ANO5 RYR1 ALB SERPIND1

3.84e-041579748d30d8e6fae93afcada6bd68799439335cd65b69
ToppCellfacs-Heart-Unknown-3m-Myeloid|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ANO5 RYR1 ALB SERPIND1

3.84e-041579742ac4695d9e4ca8d4ba19c555e9a1d86ac8f398ab
ToppCellfacs-Heart-Unknown-3m-Myeloid-monocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ANO5 RYR1 ALB SERPIND1

3.84e-041579748a393eece90fb9a1b7c356736bdb36277261fbd3
ToppCellE18.5-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_prolif|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SPTA1 NCF2 CSF2RB CD53

3.94e-04158974f61ebe3a316e4259387cd9da83707f15e6473cae
ToppCellfacs-Lung-Endomucin-24m-Myeloid|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NCF2 NLRC4 CSF2RB CD53

4.03e-04159974886cbaef39a3517514a3896b6b960d01a3af043d
ToppCellTCGA-Bladder-Solid_Tissue_Normal-Urothelial_normal_tissue-Urothelial_normal_tissue|TCGA-Bladder / Sample_Type by Project: Shred V9

LRRC2 OGN IGSF10 ARHGAP20

4.13e-041609748a41e2c96e0e170ac35daf6c403bf961b8d7c30b
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Chrna2_Glra3|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

USP29 ANO5 SNX8 MGAT4C

4.13e-041609740bfdaf979e6f128cba2928ce16bca4d3deff8ac9
ToppCellTCGA-Bladder-Solid_Tissue_Normal|TCGA-Bladder / Sample_Type by Project: Shred V9

LRRC2 OGN IGSF10 ARHGAP20

4.13e-04160974d6678996e12eaf2b735f1dfae32418cb2fabf268
ToppCellTCGA-Bladder-Solid_Tissue_Normal-Urothelial_normal_tissue|TCGA-Bladder / Sample_Type by Project: Shred V9

LRRC2 OGN IGSF10 ARHGAP20

4.13e-04160974c8dc575562b463fd30832d322c28006f18f7ab9c
ToppCell356C-Lymphocytic-NK_cells-NK_cell_A2|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

SLC16A9 SPTA1 SNX8 CDC25C

4.23e-041619748ec923c230a7a3cce5edf2a736b3a00d607c698a
ToppCellThalamus-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)|Thalamus / BrainAtlas - Mouse McCarroll V32

MAGEE1 ZWINT TACR1 MGAT4C

4.23e-041619740605134a342d74ae81f33700d6ddfcd6e03aeb7b
ToppCell367C-Lymphocytic-NK_cells-NK_cell_B1|367C / Donor, Lineage, Cell class and subclass (all cells)

IPO8 HPS3 SYNE2 UBE3C

4.23e-04161974f470b662566131dfe69a2fd01186ac8491196396
ToppCellfacs-Limb_Muscle-ForelimbandHindlimb-3m-Myeloid-macrophage|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NCF2 CSF2RB SNX8 CD53

4.32e-04162974db1e09324e9fdd5e571600cff4f2b1c0cb3c179d
ToppCelldroplet-Fat-Gat-18m-Myeloid-nan|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACER3 NCF2 SNX8 CD53

4.32e-04162974052f797d8bcab8fc6a43e0bffdd215c88ee12889
ToppCellfacs-Limb_Muscle-ForelimbandHindlimb-3m-Myeloid-nan|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NCF2 CSF2RB SNX8 CD53

4.32e-041629749734943c8b7c04e568792253b7352672a3a5cc58
ToppCellfacs-Limb_Muscle-ForelimbandHindlimb-3m-Myeloid|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NCF2 CSF2RB SNX8 CD53

4.32e-0416297448d7bee271f74b5d06c03c6ae06a662d765a6de3
ToppCell3'_v3-Lung-Hematopoietic_progenitors-Cycling_pre-Myeloid-2|Lung / Manually curated celltypes from each tissue

ZWINT IGSF10 ALB CDC25C

4.43e-0416397447300dec94dc66e965bf71fafff0a9fd24fae968
ToppCellLPS-antiTNF-Endothelial-Endothelial-FOXM1|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ZWINT KRT77 CDC25C KIF2C

4.43e-041639745285318c52aa31c9b22dc2ffff078e32e408604d
ToppCelldroplet-Bladder-nan-3m-Hematologic-leukocyte|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NCF2 RYR1 CSF2RB CD53

4.43e-041639742f32a9ab0230fdca98ffa7fd59397301d50e4f30
ToppCelldroplet-Bladder-nan-3m-Hematologic|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NCF2 RYR1 CSF2RB CD53

4.43e-041639746c2967dee563295febe2adabf503d095cb911ccf
ToppCelldroplet-Lung-21m-Hematologic-myeloid-intermediate_monocyte|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ACER3 NCF2 JAK2 ELMO2

4.53e-04164974cd0794f84dfd346807e2d803723718b7f22e9232
ToppCelldroplet-Lung-21m-Hematologic-myeloid-intermediate_monocyte-intermediate_monocyte_l4|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ACER3 NCF2 JAK2 ELMO2

4.53e-0416497412251a49fd4af32d4edb58046245548c260cf04b
ToppCellPND14-Immune-Immune_Myeloid-Granulocytic-Basophil-Basophil_mature|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SYNE1 NCF2 CSF2RB CD53

4.53e-04164974f4de9f18134a06f3d7fcf5b50b8e21c1506e2083
ToppCellfacs-Trachea-3m-Hematologic-myeloid-tracheal_macrophage-macrophage_of_tracheal_l15|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

NCF2 RYR1 CSF2RB CD53

4.53e-041649745ca7b69684a8bb12dd0b45e7ad94e30d16ed01ce
ToppCellPND14-Immune-Immune_Myeloid-Granulocytic-Basophil|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SYNE1 NCF2 CSF2RB CD53

4.53e-04164974dc22b1fef49c1557a0b63c536eaba574dfcab715
ToppCellfacs-Liver-Liver_non-hepato/SCs-18m-Myeloid-nan|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NCF2 IQGAP1 CSF2RB CD53

4.53e-0416497445a6d809d92fd4eee906da3c812282bacffc9f2f
ToppCellfacs-Liver-Liver_non-hepato/SCs-18m-Myeloid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NCF2 IQGAP1 CSF2RB CD53

4.53e-04164974aa4358311fc767c292897e3328309d1bcda392d4
Disease11beta-hydroxyandrosterone glucuronide measurement

XDH NLRC4 DPY30

6.53e-0612933EFO_0800573
DiseaseMesenteric Vascular Occlusion

JAK2 SERPIND1

9.83e-062932C0025472
Diseaseasthma, Eczema, allergic rhinitis

TOB2 IQGAP1 TLR10 JAK2 CLEC16A

4.16e-05121935EFO_0005854, HP_0000964, MONDO_0004979
DiseaseAutosomal dominant Emery-Dreifuss muscular dystrophy

SYNE1 SYNE2

5.87e-054932cv:CN293514
Diseaseautosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions 2 (implicated_via_orthology)

SLC25A5 SLC25A6

5.87e-054932DOID:0111517 (implicated_via_orthology)
DiseaseAutosomal Recessive Emery-Dreifuss Muscular Dystrophy

SYNE1 SYNE2

9.77e-055932C1450051
DiseaseAutosomal Dominant Emery-Dreifuss Muscular Dystrophy (disorder)

SYNE1 SYNE2

9.77e-055932C0410190
Diseaseinterleukin 18 measurement

XDH NLRC4 DPY30 RAD17

9.97e-0576934EFO_0004581
DiseaseEmery-Dreifuss muscular dystrophy

SYNE1 SYNE2

1.46e-046932cv:C0410189
Diseasesurvival time, prostate carcinoma

SUCLG2 DGKK

1.46e-046932EFO_0000714, EFO_0001663
DiseaseMuscular Dystrophy, Emery-Dreifuss

SYNE1 SYNE2

1.46e-046932C0410189
Diseasehyperuricemia (implicated_via_orthology)

XDH JAK2

2.04e-047932DOID:1920 (implicated_via_orthology)
DiseaseHermansky-Pudlak syndrome (is_implicated_in)

HPS3 HPS5

2.04e-047932DOID:3753 (is_implicated_in)
DiseaseX-Linked Emery-Dreifuss Muscular Dystrophy

SYNE1 SYNE2

2.04e-047932C0751337
DiseaseHermanski-Pudlak Syndrome

HPS3 HPS5

4.35e-0410932C0079504
DiseaseHermansky-Pudlak syndrome

HPS3 HPS5

4.35e-0410932cv:C0079504
Diseasealopecia areata

SLC16A9 SYT14 CLEC16A

5.34e-0450933EFO_0004192
DiseaseEmery-Dreifuss muscular dystrophy (implicated_via_orthology)

SYNE1 SYNE2

6.35e-0412932DOID:11726 (implicated_via_orthology)
Diseaseplatelet storage pool deficiency (implicated_via_orthology)

HPS3 HPS5

1.00e-0315932DOID:2223 (implicated_via_orthology)
Diseaseobesity (biomarker_via_orthology)

NPY2R XDH NCF2 JAK2

1.22e-03147934DOID:9970 (biomarker_via_orthology)
Diseaserenal fibrosis (implicated_via_orthology)

XDH NCF2

1.30e-0317932DOID:0050855 (implicated_via_orthology)
Diseaseallergic disease

TOB2 IQGAP1 JAK2 CSF2RB CLEC16A

1.37e-03258935MONDO_0005271
Diseaseetiocholanolone glucuronide measurement

XDH NLRC4

1.62e-0319932EFO_0800362
Diseaseglycerol measurement

ANO5 ZWINT

3.04e-0326932EFO_0010115
Diseaseacute necrotizing pancreatitis (biomarker_via_orthology)

PDX1 TACR1

3.04e-0326932DOID:0080998 (biomarker_via_orthology)

Protein segments in the cluster

PeptideGeneStartEntry
RFTYKFNFNKLVLVN

ERF

101

P50548
FKIKNSVNYHLLFTL

ACER3

111

Q9NUN7
ALNFAFKDKYKQIFL

SLC25A6

86

P12236
LKLLKYVLFFFNLLF

CD53

6

P19397
ENFKALVLIAFAQYL

ALB

41

P02768
LNFIVILILNFFYEK

ANO5

521

Q75V66
ALNFAFKDKYKQIFL

SLC25A5

86

P05141
VYFFLFNDVLIITKK

ARHGEF26

681

Q96DR7
KLLESFKIQYLQFLA

DOT1L

486

Q8TEK3
TTFAIIENLKYFLLK

C1GALT1C1

146

Q96EU7
FLKLVASEQLFIYVN

ATG12

91

O94817
IKVTKYFLFLFNLIF

CD82

6

P27701
VNVNLLIFLLNKKFY

IQGAP1

1641

P46940
FKEFLLRATKYNKLQ

RAD17

196

O75943
KYLHKFFNIPFLQLQ

RABL6

221

Q3YEC7
KLKYLINLETLQSAF

JAK2

251

O60674
QVLDLKEYKLIFTVF

NPY2R

296

P49146
AKFAFNLYRVLKDQV

SERPIND1

131

P05546
FLVNEFLLKNNYKLT

RELCH

261

Q9P260
VKFRSKQNVDYAFLL

MGAT4C

196

Q9UBM8
FKNKVFSALFIAILL

SLC16A9

301

Q7RTY1
KFKQYLNPSQVFDLL

DGKK

511

Q5KSL6
NIKVGLLEQFLLYKF

MAGEB5

41

Q9BZ81
AELLQFLLVKDQSKY

MAGEE1

496

Q9HCI5
LIDYKILGLQFKLFA

NCF2

106

P19878
TLFHTFYDLLIQKNK

NLRC4

361

Q9NPP4
EIQTAYSKFKQLFLI

MTMR12

326

Q9C0I1
VLFNNYITAALKLLE

HERC3

581

Q15034
KILLYSLNLQFKGIQ

KIAA1109

3151

Q2LD37
EILACQFLKKYFFLL

HPS5

771

Q9UPZ3
QFLKKYFFLLNLKRA

HPS5

776

Q9UPZ3
KLFQLIYYLVVAILK

ENDOD1

341

O94919
AQLLELEKEFLFNKY

PDX1

156

P52945
SVLIQKQIFKIFYAL

IPO7

196

O95373
SFSLYLIQLVFKNLQ

NEMP1

226

O14524
DFLKFFKNALNLIDL

KCNS2

251

Q9ULS6
SLLEQLKLFYEQQLF

KBTBD2

16

Q8IY47
LKLFYEQQLFTDIVL

KBTBD2

21

Q8IY47
KYVNNFILKNFPALL

KLHL9

171

Q9P2J3
QIKELEEKFLFLFLF

JAKMIP3

821

Q5VZ66
ELQSFLLYKNKLTYL

LRRC2

261

Q9BYS8
ANAFKKLNNLTFLYL

OGN

206

P20774
SLKKVAYNALFTNLF

TUBGCP6

36

Q96RT7
LFFKIFSQEYINLLL

HM13

91

Q8TCT9
LIFKAFLLKFVNSYT

ANO1

606

Q5XXA6
QKKNLTFYLLLSLIL

PCDHGC3

686

Q9UN70
QFLLEKFLQHASYKL

GREB1L

1786

Q9C091
NLYSQEELFNFFLKK

CDC25C

346

P30307
LQQKDYFIIFLLILL

OSBPL8

866

Q9BZF1
FRLFPEYKNNKLFLT

CTSA

161

P10619
QQRLQSLYFKKKFAE

DAAM1

771

Q9Y4D1
LSYLQIFKISFIKFL

IGSF10

176

Q6WRI0
IFKISFIKFLYLSDN

IGSF10

181

Q6WRI0
IQLFKALKQQDYLSL

CSF2RB

871

P32927
LLKQFDDVLIYLNSF

TTC26

371

A0AVF1
YFAIIEKKTNDLLLL

CCDC63

446

Q8NA47
IQTYAIALINALFLK

ELMO2

231

Q96JJ3
ILFLYNDLLKKRAAF

DCST1

591

Q5T197
LEYLKNVLLQFIFLK

GCC2

1616

Q8IWJ2
LSKQLLAYEKQNFAL

APPL2

61

Q8NEU8
FFFNVYINKEKRLQL

HOXC11

251

O43248
IEFLASYLLKNKAQF

DPY30

81

Q9C005
LYNKQKVLELFESFR

SACS

286

Q9NZJ4
FYLFFFTEKILKILL

SLC39A14

231

Q15043
KFFAKILLPLINQYF

RYR1

2996

P21817
FFEIYNGKLFDLLNK

KIF2C

401

Q99661
FLNLVYKSLKADIVL

CEBPZ

566

Q03701
QELQKFLFLLFLLVY

OR4D1

21

Q15615
YSVLLQKQILKIFYA

IPO8

196

O15397
FLFNDLFVVAKIKYN

ARHGAP20

106

Q9P2F6
LLNFAYIAKILNDYK

TAS2R10

141

Q9NYW0
YFIKQILLNLGVIFF

TAS2R10

171

Q9NYW0
YLLKIANFSNLIFLR

TAS2R45

106

P59539
LLFLYINKKFCFENV

SYT14

41

Q8NB59
KLNLFLDLLQSYKDL

SNX8

316

Q9Y5X2
VFYIQQDKIYLLLTK

TLR10

311

Q9BXR5
LFTSLADNKYIILQK

SYNE1

6496

Q8NF91
YINLDKKLFELFLTL

SYNE2

4526

Q8WXH0
LVLFSLKYQIINEEF

HPS3

156

Q969F9
NFVNFRYLIKFLAKL

ARHGAP17

371

Q68EM7
LINIDLFKDYKLIFQ

NSUN7

261

Q8NE18
DLYLKKFIQQVYLAI

TACR1

276

P25103
ILVFLLAELNTFYLK

PTDSS2

321

Q9BVG9
LLKVFQALFLNDFNK

SETD9

56

Q8NE22
YYISFLKTLSLKLNN

CLEC16A

141

Q2KHT3
YKSNLQFKLDVLSLI

CNGA1

236

P29973
KNILINFYRAFNLDK

C11orf40

51

Q8WZ69
NKFEVNCLIKLFYDL

CLXN

21

Q9HAE3
FNYLEEFKQQRLLKS

SPG11

2361

Q96JI7
AADQITKLYNLFLKI

SUCLG2

221

Q96I99
TFLQLLYTLQGKLLF

ZWINT

211

O95229
ELYKLSIFNFLLTVA

TMC8

426

Q8IU68
FIKSFLVFINLYCIK

CSE1L

786

P55060
LENAFVLYNKFITLF

STAMBPL1

71

Q96FJ0
NTVKFLLLFYLKKLT

TMC4

556

Q7Z404
LLLFNTTENLYKKYV

WASH4P

186

A8MWX3
LKNNVFLFIDKLSYR

USP29

76

Q9HBJ7
ALTLKYKLDNQFELV

SRPRA

51

P08240
FFKFYLTVLQKLGQE

XDH

516

P47989
RKESLNEAQKFYLFL

SPTA1

1281

P02549
FRLSKKITNNIVYFL

TGS1

791

Q96RS0
KVALNFIISYLYNKL

TOB2

6

Q14106
LLFFYKQNEDSKRLI

UBE3C

101

Q15386
VNFLKYLFLTELSQV

KRT77

296

Q7Z794