Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionmolecular adaptor activity

RETREG2 RBM33 OBSL1 BRD3 TDG CHD4 CBX4 ATG2A RAD54L2 AHDC1 ZXDA ZXDB PARP10 KMT2D SHANK2 PIK3R1 EIF4G1 MAMSTR MED12L SCRIB MED12 ZNF541 MRTFA

5.16e-06135612023GO:0060090
GeneOntologyMolecularFunctionprotein-macromolecule adaptor activity

RETREG2 RBM33 OBSL1 BRD3 TDG CHD4 CBX4 ATG2A RAD54L2 ZXDA ZXDB PARP10 KMT2D SHANK2 PIK3R1 MAMSTR MED12L SCRIB MED12 ZNF541 MRTFA

5.26e-06116012021GO:0030674
GeneOntologyMolecularFunctiontranscription coregulator activity

TDG CHD4 CBX4 RAD54L2 ZXDA ZXDB PARP10 KMT2D MAMSTR MED12L MED12 ZNF541 MRTFA

3.39e-0556212013GO:0003712
GeneOntologyMolecularFunctionmodification-dependent protein binding

CHD8 BRD3 CBX4 XRCC1 PWWP2A PARP10 TAF1L

2.50e-042061207GO:0140030
GeneOntologyMolecularFunctionchromatin binding

CHD8 BRD3 CHD4 CBX4 AHDC1 BAHD1 PWWP2A AUTS2 CDT1 HSF1 TAF1L MED12 RAD21

5.05e-0473912013GO:0003682
GeneOntologyBiologicalProcessactin cytoskeleton organization

PDGFRB WASHC1 OBSL1 CAVIN3 BCAR1 SMTN PIK3R1 PIK3R2 PAK1 PRKAR1A AUTS2 PAK3 TTC17 TNXB MRTFA

5.44e-0580311815GO:0030036
GeneOntologyBiologicalProcesspositive regulation of plasma membrane bounded cell projection assembly

WASHC1 DEF8 PLEKHM1 PIK3R1 AUTS2 PPP1R35

7.60e-051231186GO:0120034
GeneOntologyBiologicalProcessregulation of cell cycle process

CCSAP PDGFRB OBSL1 PIK3R4 CDCA2 IER3 EIF4G1 CCAR2 PKN2 CDT1 PPP1R35 HSF1 CSPP1 CDC23 RAD21

9.63e-0584511815GO:0010564
GeneOntologyBiologicalProcessregulation of plasma membrane bounded cell projection organization

NUMBL FAT3 WASHC1 DEF8 OBSL1 PLEKHM1 TBC1D17 NFATC4 PIK3R1 PAK1 AUTS2 PAK3 PPP1R35 GOLGA2 SEZ6

9.75e-0584611815GO:0120035
GeneOntologyBiologicalProcessorganelle fission

CCSAP PDGFRB WASHC1 OBSL1 STAT2 CDCA2 CDT1 HSF1 GOLGA2 ZNF541 CDC23 RAD21

1.07e-0457111812GO:0048285
GeneOntologyBiologicalProcessregulation of cell projection organization

NUMBL FAT3 WASHC1 DEF8 OBSL1 PLEKHM1 TBC1D17 NFATC4 PIK3R1 PAK1 AUTS2 PAK3 PPP1R35 GOLGA2 SEZ6

1.21e-0486311815GO:0031344
GeneOntologyBiologicalProcesspositive regulation of cell projection organization

NUMBL WASHC1 DEF8 OBSL1 PLEKHM1 PIK3R1 PAK1 AUTS2 PAK3 PPP1R35 GOLGA2

1.27e-0449411811GO:0031346
HumanPhenoDepressed nasal bridge

PDGFRB SCARF2 OBSL1 CHD8 AHDC1 KMT2D PIK3R2 DLL3 MED12L PRKAR1A AUTS2 CSPP1 MED12 GOLGA2 RAD21

2.08e-056123915HP:0005280
HumanPhenoFlattened nasal bridge

PDGFRB SCARF2 OBSL1 CHD8 AHDC1 KMT2D PIK3R2 DLL3 MED12L PRKAR1A AUTS2 CSPP1 MED12 GOLGA2 RAD21

2.08e-056123915HP:0000425
HumanPhenoGracile long bones

PDGFRB SCARF2 OBSL1 PIK3R1 CDT1 MED12

4.93e-0589396HP:0003061
HumanPhenoSlender long bone

PDGFRB SCARF2 OBSL1 PIK3R1 CDT1 MED12

4.93e-0589396HP:0003100
HumanPhenoAbnormality of mouth shape

CCDC174 CHD8 KMT2D PIK3R1 DCHS1 MED12L PRKAR1A PAK3 MED12 RAD21

5.00e-052943910HP:0011338
HumanPhenoElevated circulating thyroid-stimulating hormone concentration

PLVAP PDGFRB SLC16A2 PRKAR1A

6.97e-0530394HP:0002925
HumanPhenoAbnormal auditory canal morphology

KMT2D DCHS1 CDT1 MED12 MRTFA RAD21

8.49e-0598396HP:0000372
DomainMediator_Med12

MED12L MED12

3.96e-0521182IPR019035
DomainMed12

MED12L MED12

3.96e-0521182PF09497
DomainMediator_Med12_LCEWAV

MED12L MED12

3.96e-0521182IPR021990
DomainMediator_Med12_catenin-bd

MED12L MED12

3.96e-0521182IPR021989
DomainMed12-PQL

MED12L MED12

3.96e-0521182PF12144
DomainMed12-LCEWAV

MED12L MED12

3.96e-0521182PF12145
DomainMed12

MED12L MED12

3.96e-0521182SM01281
DomainPI3K_P85_iSH2

PIK3R1 PIK3R2

1.18e-0431182IPR032498
DomainPI3K_P85_iSH2

PIK3R1 PIK3R2

1.18e-0431182PF16454
DomainCRIB

PAK1 PAK3 TNK2

2.59e-04201183PS50108
DomainCRIB_dom

PAK1 PAK3 TNK2

3.01e-04211183IPR000095
Domainzf-RING_9

DEF8 PLEKHM1

3.91e-0451182PF13901
DomainPI3kinase_P85

PIK3R1 PIK3R2

3.91e-0451182IPR001720
DomainDUF4206

DEF8 PLEKHM1

3.91e-0451182SM01175
DomainZf-RING_9

DEF8 PLEKHM1

3.91e-0451182IPR025258
DomainChromo_domain

CHD8 CHD4 CBX4

4.52e-04241183IPR023780
DomainChromo

CHD8 CHD4 CBX4

5.75e-04261183PF00385
DomainF-box-assoc_dom

NCCRP1 FBXO27

5.84e-0461182IPR007397
DomainFBA

NCCRP1 FBXO27

5.84e-0461182PS51114
DomainFBA

NCCRP1 FBXO27

5.84e-0461182PF04300
DomainFBA

NCCRP1 FBXO27

5.84e-0461182SM01198
DomainPAK_BD

PAK1 PAK3

5.84e-0461182IPR033923
DomainCHROMO_1

CHD8 CHD4 CBX4

7.18e-04281183PS00598
DomainCHROMO_2

CHD8 CHD4 CBX4

7.18e-04281183PS50013
DomainSNF2_N

CHD8 CHD4 RAD54L2

1.07e-03321183IPR000330
DomainChromodomain-like

CHD8 CHD4 CBX4

1.07e-03321183IPR016197
DomainSNF2_N

CHD8 CHD4 RAD54L2

1.07e-03321183PF00176
DomainChromo/shadow_dom

CHD8 CHD4 CBX4

1.17e-03331183IPR000953
DomainCHROMO

CHD8 CHD4 CBX4

1.17e-03331183SM00298
DomainPHD

JADE2 DIDO1 CHD4 KMT2D

1.30e-03751184PF00628
DomainZnf_PHD-finger

JADE2 DIDO1 CHD4 KMT2D

1.58e-03791184IPR019787
DomainDUF4939

PEG10 RTL3

1.72e-03101182PF16297
DomainDUF4939

PEG10 RTL3

1.72e-03101182IPR032549
DomainLDOC1-rel

PEG10 RTL3

2.10e-03111182IPR032567
DomainZnf_FYVE_PHD

JADE2 DIDO1 CHD4 RPH3A KMT2D

2.42e-031471185IPR011011
DomainPHD

JADE2 DIDO1 CHD4 KMT2D

2.45e-03891184SM00249
Domain-

PAK1 PAK3

2.51e-031211823.90.810.10
DomainZnf_PHD

JADE2 DIDO1 CHD4 KMT2D

2.65e-03911184IPR001965
DomainZF_PHD_2

JADE2 DIDO1 CHD4 KMT2D

3.10e-03951184PS50016
DomainZF_PHD_1

JADE2 DIDO1 CHD4 KMT2D

3.22e-03961184PS01359
DomainPBD

PAK1 PAK3

4.48e-03161182SM00285
DomainTPR_8

TTC7B TTC17 CDC23

4.58e-03531183PF13181
DomainHelicase_C

CHD8 CHD4 RAD54L2 DDX39A

4.74e-031071184PF00271
DomainHELICc

CHD8 CHD4 RAD54L2 DDX39A

4.74e-031071184SM00490
DomainHelicase_C

CHD8 CHD4 RAD54L2 DDX39A

4.90e-031081184IPR001650
DomainPBD

PAK1 PAK3

5.06e-03171182PF00786
DomainHELICASE_CTER

CHD8 CHD4 RAD54L2 DDX39A

5.06e-031091184PS51194
DomainHELICASE_ATP_BIND_1

CHD8 CHD4 RAD54L2 DDX39A

5.06e-031091184PS51192
DomainDEXDc

CHD8 CHD4 RAD54L2 DDX39A

5.06e-031091184SM00487
DomainHelicase_ATP-bd

CHD8 CHD4 RAD54L2 DDX39A

5.23e-031101184IPR014001
PathwayWP_FOCAL_ADHESION

PDGFRB BCAR1 PIK3R4 PIK3R1 PIK3R2 PAK1 PAK3 TNK2 TNXB

7.78e-07187779MM15913
PathwayWP_EGFR1_SIGNALING_PATHWAY

RALGDS BCAR1 STAT2 PIK3R1 PIK3R2 PAK1 PRKAR1A TNK2 PKN2

8.14e-07188779MM15828
PathwayREACTOME_RHOJ_GTPASE_CYCLE

PIK3R1 PIK3R2 PAK1 PAK3 SCRIB

1.20e-0555775M41815
PathwayWP_FOCAL_ADHESION

PDGFRB BCAR1 PIK3R1 PIK3R2 PAK1 PAK3 TNK2 TNXB

1.25e-05199778M39402
PathwayREACTOME_DOWNSTREAM_SIGNAL_TRANSDUCTION

PDGFRB BCAR1 PIK3R1 PIK3R2

1.31e-0527774MM14712
PathwayWP_REGULATION_OF_ACTIN_CYTOSKELETON

PDGFRB BCAR1 PIK3R4 PIK3R1 PIK3R2 PAK1 PAK3

1.73e-05150777M39520
PathwayREACTOME_DOWNSTREAM_SIGNAL_TRANSDUCTION

PDGFRB BCAR1 PIK3R1 PIK3R2

1.76e-0529774M779
PathwayWP_REGULATION_OF_ACTIN_CYTOSKELETON

PDGFRB BCAR1 PIK3R4 PIK3R1 PIK3R2 PAK1 PAK3

1.89e-05152777MM15834
PathwayREACTOME_SIGNALING_BY_LTK

PIK3R1 PIK3R2 TNK2

2.51e-0511773MM17235
PathwayREACTOME_CD28_CO_STIMULATION

PIK3R1 PIK3R2 PAK1 PAK3

2.99e-0533774M11725
PathwayREACTOME_SIGNALING_BY_LTK

PIK3R1 PIK3R2 TNK2

3.33e-0512773M48256
PathwayREACTOME_CD28_CO_STIMULATION

PIK3R1 PIK3R2 PAK1 PAK3

3.37e-0534774MM14992
PathwayREACTOME_RHOU_GTPASE_CYCLE

PIK3R1 PIK3R2 PAK1 PAK3

5.85e-0539774MM15607
PathwayWP_RAS_SIGNALING

RALGDS PDGFRB RASAL3 PIK3R1 PIK3R2 PAK1 PAK3

6.41e-05184777M39764
PathwayREACTOME_RHOU_GTPASE_CYCLE

PIK3R1 PIK3R2 PAK1 PAK3

6.48e-0540774M41816
PathwayPID_PDGFRB_PATHWAY

PDGFRB BCAR1 SIPA1 PIK3R1 PIK3R2 PAK1

7.28e-05129776M186
PathwayREACTOME_SIGNALING_BY_RECEPTOR_TYROSINE_KINASES

RALGDS PDGFRB CHD4 BCAR1 PIK3R4 PIK3R1 PIK3R2 PAK1 PAK3 TNK2

8.78e-054187710MM15587
PathwayKEGG_FOCAL_ADHESION

PDGFRB BCAR1 PIK3R1 PIK3R2 PAK1 PAK3 TNXB

1.05e-04199777M7253
PathwayWP_PANCREATIC_ADENOCARCINOMA_PATHWAY

RALGDS PIK3R1 PIK3R2 PAK1 PAK3

1.24e-0489775M39732
PathwayPID_EPHA2_FWD_PATHWAY

BCAR1 PIK3R1 PAK1

1.43e-0419773M273
PathwayPID_CXCR4_PATHWAY

BCAR1 STAT2 PIK3R1 PIK3R2 PAK1

2.14e-04100775M124
PathwayREACTOME_SIGNALING_BY_VEGF

BCAR1 PIK3R1 PIK3R2 PAK1 PAK3

2.46e-04103775MM14752
PathwayWP_EGFEGFR_SIGNALING

RALGDS BCAR1 PIK3R1 PIK3R2 PAK1 TNK2

2.54e-04162776M39334
PathwayREACTOME_SIGNALING_BY_PDGF

PDGFRB BCAR1 PIK3R1 PIK3R2

2.61e-0457774MM14713
PathwayREACTOME_SIGNALING_BY_PDGF

PDGFRB BCAR1 PIK3R1 PIK3R2

2.79e-0458774M2049
PathwayREACTOME_SIGNALING_BY_VEGF

BCAR1 PIK3R1 PIK3R2 PAK1 PAK3

2.81e-04106775M27077
PathwayWP_MET_IN_TYPE_1_PAPILLARY_RENAL_CELL_CARCINOMA

PIK3R1 PIK3R2 PAK1 PAK3

2.98e-0459774M39750
PathwayKEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY

NFATC4 PIK3R1 PIK3R2 PAK1 PAK3

3.07e-04108775M9904
PathwayREACTOME_MAPK_FAMILY_SIGNALING_CASCADES

RALGDS PDGFRB RASAL3 PIK3R1 PIK3R2 PAK1 PAK3 APBB1IP

3.34e-04318778MM15278
PathwayWP_NOTCH_SIGNALING_WP61

NUMBL PIK3R1 PIK3R2 DLL3

3.39e-0461774M39540
PathwayREACTOME_SIGNALING_BY_NTRK1_TRKA

RALGDS CHD4 PIK3R1 PIK3R2

3.84e-0463774MM14714
PathwayREACTOME_MAPK_FAMILY_SIGNALING_CASCADES

RALGDS PDGFRB RASAL3 PIK3R1 PIK3R2 PAK1 PAK3 APBB1IP

4.03e-04327778M27565
PathwayWP_THYROID_STIMULATING_HORMONE_TSH_SIGNALING

RALGDS PIK3R1 PIK3R2 SCRIB

4.59e-0466774M39684
PathwayREACTOME_COSTIMULATION_BY_THE_CD28_FAMILY

PIK3R1 PIK3R2 PAK1 PAK3

4.59e-0466774MM14990
PathwayKEGG_RENAL_CELL_CARCINOMA

PIK3R1 PIK3R2 PAK1 PAK3

5.74e-0470774M13266
PathwayPID_CDC42_PATHWAY

BCAR1 PIK3R1 PAK1 TNK2

5.74e-0470774M81
PathwayREACTOME_SIGNALING_BY_LTK_IN_CANCER

PIK3R1 PIK3R2

6.08e-047772M48255
PathwayBIOCARTA_CDC42RAC_PATHWAY

PIK3R1 PAK1

6.08e-047772MM1487
PathwayREACTOME_SIGNALING_BY_RECEPTOR_TYROSINE_KINASES

RALGDS PDGFRB CHD4 BCAR1 PIK3R4 PIK3R1 PIK3R2 PAK1 PAK3 TNK2

6.08e-045327710M27870
PathwayPID_NETRIN_PATHWAY

BCAR1 PIK3R1 PAK1

6.93e-0432773M108
PathwayREACTOME_COSTIMULATION_BY_THE_CD28_FAMILY

PIK3R1 PIK3R2 PAK1 PAK3

7.09e-0474774M17386
PathwayREACTOME_SIGNALING_BY_NTRKS

RALGDS CHD4 PIK3R1 PIK3R2

7.46e-0475774MM14652
PathwayBIOCARTA_CDC42RAC_PATHWAY

PIK3R1 PAK1

8.07e-048772M5291
PathwayREACTOME_PI3K_AKT_ACTIVATION

PIK3R1 PIK3R2

8.07e-048772MM14776
PathwayPID_ERBB1_RECEPTOR_PROXIMAL_PATHWAY

PIK3R1 PIK3R2 PAK1

9.04e-0435773M127
PathwayKEGG_MEDICUS_REFERENCE_PDL_PD1_SHP_PI3K_SIGNALING_PATHWAY

PIK3R1 PIK3R2

1.03e-039772M47757
PathwayKEGG_MEDICUS_REFERENCE_ICOSLG_ICOS_PI3K_SIGNALING_PATHWAY

PIK3R1 PIK3R2

1.03e-039772M47972
PathwayREACTOME_PI3K_AKT_ACTIVATION

PIK3R1 PIK3R2

1.03e-039772M714
PathwayKEGG_REGULATION_OF_ACTIN_CYTOSKELETON

PDGFRB BCAR1 PIK3R1 PIK3R2 PAK1 PAK3

1.08e-03213776M18306
PathwayWP_G13_SIGNALING

PIK3R2 PAK3 TNK2

1.15e-0338773M39606
PathwayWP_G13_SIGNALING_PATHWAY

PIK3R2 PAK3 TNK2

1.24e-0339773MM15898
PathwayKEGG_ERBB_SIGNALING_PATHWAY

PIK3R1 PIK3R2 PAK1 PAK3

1.30e-0387774M12467
PathwayWP_NEURAL_CREST_CELL_MIGRATION_DURING_DEVELOPMENT

PIK3R4 PAK1 PAK3

1.34e-0340773M39798
PathwayWP_PDGF_PATHWAY

PDGFRB PIK3R1 PAK1

1.34e-0340773M39555
PathwayREACTOME_IRS_MEDIATED_SIGNALLING

PIK3R4 PIK3R1 PIK3R2

1.44e-0341773MM14505
PathwayREACTOME_RND3_GTPASE_CYCLE

PIK3R1 PIK3R2 SCRIB

1.54e-0342773M41826
PathwayPID_TCPTP_PATHWAY

PDGFRB PIK3R1 PIK3R2

1.54e-0342773M91
PathwayREACTOME_RND3_GTPASE_CYCLE

PIK3R1 PIK3R2 SCRIB

1.54e-0342773MM15677
PathwayREACTOME_CDC42_GTPASE_CYCLE

PIK3R1 PIK3R2 PAK1 PAK3 SCRIB

1.57e-03155775M41808
PathwayREACTOME_INTRACELLULAR_SIGNALING_BY_SECOND_MESSENGERS

PDGFRB CHD4 CBX4 IER3 PIK3R1 PIK3R2 PRKAR1A

1.58e-03313777M27867
PathwayWP_ERBB_SIGNALING

PIK3R1 PIK3R2 PAK1 PAK3

1.60e-0392774M39715
PathwayREACTOME_RND2_GTPASE_CYCLE

PIK3R1 PIK3R2 SCRIB

1.65e-0343773M41827
PathwayWP_NEURAL_CREST_CELL_MIGRATION_IN_CANCER

PIK3R4 PAK1 PAK3

1.65e-0343773M39788
PathwayPID_ERBB2_ERBB3_PATHWAY

NFATC4 PIK3R1 PIK3R2

1.77e-0344773M175
PathwayREACTOME_RND2_GTPASE_CYCLE

PIK3R1 PIK3R2 SCRIB

1.77e-0344773MM15678
PathwayREACTOME_CD28_DEPENDENT_VAV1_PATHWAY

PAK1 PAK3

1.88e-0312772M13618
PathwayREACTOME_SIGNALING_BY_PDGFRA_TRANSMEMBRANE_JUXTAMEMBRANE_AND_KINASE_DOMAIN_MUTANTS

PIK3R1 PIK3R2

1.88e-0312772M29851
PathwayREACTOME_CD28_DEPENDENT_VAV1_PATHWAY

PAK1 PAK3

1.88e-0312772MM14994
PathwaySIG_CHEMOTAXIS

PIK3R1 PAK1 PAK3

1.89e-0345773M5193
PathwayWP_TRANSLATION_INHIBITORS_IN_CHRONICALLY_ACTIVATED_PDGFRA_CELLS

PIK3R1 PIK3R2 EIF4G1

2.01e-0346773M39805
PathwayWP_CHEMOKINE_SIGNALING

BCAR1 STAT2 PIK3R1 PIK3R2 PAK1

2.07e-03165775M39400
PathwayREACTOME_SIGNALING_BY_TYPE_1_INSULIN_LIKE_GROWTH_FACTOR_1_RECEPTOR_IGF1R

PIK3R4 PIK3R1 PIK3R2

2.14e-0347773MM14885
PathwayREACTOME_ACTIVATION_OF_RAC1

PAK1 PAK3

2.21e-0313772M6322
PathwayREACTOME_IRS_MEDIATED_SIGNALLING

PIK3R4 PIK3R1 PIK3R2

2.27e-0348773M26916
PathwayREACTOME_INSULIN_RECEPTOR_SIGNALLING_CASCADE

PIK3R4 PIK3R1 PIK3R2

2.27e-0348773MM15441
PathwayWP_INTEGRINMEDIATED_CELL_ADHESION

BCAR1 PIK3R2 PAK1 PAK3

2.33e-03102774M39577
PathwayWP_INTEGRINMEDIATED_CELL_ADHESION

BCAR1 PIK3R2 PAK1 PAK3

2.33e-03102774MM15830
PathwayBIOCARTA_NFAT_PATHWAY

NFATC4 PIK3R1 PRKAR1A

2.41e-0349773MM1442
PathwayREACTOME_INTRACELLULAR_SIGNALING_BY_SECOND_MESSENGERS

PDGFRB CHD4 IER3 PIK3R1 PIK3R2 PRKAR1A

2.53e-03252776MM15585
PathwayREACTOME_SEMA3A_PAK_DEPENDENT_AXON_REPULSION

PAK1 PAK3

2.57e-0314772MM15029
PathwayWP_CANCER_IMMUNOTHERAPY_BY_CTLA4_BLOCKADE

PIK3R1 PIK3R2

2.57e-0314772M39840
PathwayREACTOME_RAC1_GTPASE_CYCLE

PIK3R1 PIK3R2 PAK1 PAK3 PKN2

2.68e-03175775MM15599
PathwayBIOCARTA_NFAT_PATHWAY

NFATC4 PIK3R1 PRKAR1A

2.70e-0351773M2288
PathwayPID_PTP1B_PATHWAY

PDGFRB BCAR1 PIK3R1

2.86e-0352773M50
PathwayREACTOME_P130CAS_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS

BCAR1 APBB1IP

2.95e-0315772M12101
PathwayKEGG_MEDICUS_REFERENCE_BCR_BCAP_CD19_PI3K_SIGNALING_PATHWAY

PIK3R1 PIK3R2

2.95e-0315772M47971
PathwayREACTOME_P130CAS_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS

BCAR1 APBB1IP

2.95e-0315772MM14961
PathwayREACTOME_INTERLEUKIN_7_SIGNALING

PIK3R1 PIK3R2

2.95e-0315772MM14536
PathwayREACTOME_TCR_SIGNALING

PIK3R1 PIK3R2 PAK1 PAK3

3.17e-03111774MM14803
PathwayREACTOME_SIGNALING_BY_TYPE_1_INSULIN_LIKE_GROWTH_FACTOR_1_RECEPTOR_IGF1R

PIK3R4 PIK3R1 PIK3R2

3.18e-0354773M27168
PathwayREACTOME_INSULIN_RECEPTOR_SIGNALLING_CASCADE

PIK3R4 PIK3R1 PIK3R2

3.18e-0354773M620
PathwayWP_INTERFERON_TYPE_I_SIGNALING

STAT2 PIK3R1 PIK3R2

3.18e-0354773M39435
PathwayREACTOME_RAC1_GTPASE_CYCLE

PIK3R1 PIK3R2 PAK1 PAK3 PKN2

3.32e-03184775M41809
PathwayWP_CHEMOKINE_SIGNALING_PATHWAY

BCAR1 STAT2 PIK3R1 PIK3R2 PAK1

3.32e-03184775MM15943
PathwayREACTOME_SEMA3A_PAK_DEPENDENT_AXON_REPULSION

PAK1 PAK3

3.36e-0316772M16498
PathwayKEGG_MEDICUS_REFERENCE_COHESIN_DISSOCIATION_IN_ANAPHASE

CDC23 RAD21

3.36e-0316772M47871
PathwayREACTOME_RHOJ_GTPASE_CYCLE

PIK3R1 PIK3R2

3.36e-0316772MM15605
PathwayREACTOME_NEGATIVE_REGULATION_OF_THE_PI3K_AKT_NETWORK

PDGFRB IER3 PIK3R1 PIK3R2

3.38e-03113774MM14783
PathwayWP_GASTRIN_SIGNALING

BCAR1 PIK3R1 PIK3R2 PAK1

3.60e-03115774M39866
PathwayKEGG_CHEMOKINE_SIGNALING_PATHWAY

BCAR1 STAT2 PIK3R1 PIK3R2 PAK1

3.64e-03188775M4844
Pubmed

A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.

ACD NUMBL RBM33 CCDC174 CAVIN3 ATG2A NCKAP5L STAT2 TBC1D17 PIK3R4 SHANK2 PRKAR1A BLOC1S3 CCAR2 CDT1 PPP1R35 R3HDM1 MED12 GOLGA2 MRTFA CDC23

7.74e-1110381212126673895
Pubmed

Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.

ATG2A RAD54L2 BCAR1 APOBR PRR14 RASAL3 NFATC4 PIK3R1 PIK3R2 IPCEF1 PAK1 TNK2 WNK4 MRTFA

3.60e-104301211435044719
Pubmed

A human MAP kinase interactome.

RALGDS RBM33 JADE2 CHD8 NCKAP5L RASAL3 PIK3R1 PIK3R2 PAK1 PRKAR1A PAK3 TNK2 WASH2P GOLGA2

1.74e-094861211420936779
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

NUMBL ZBTB22 DIDO1 CHD8 CHD4 SIPA1 DNAJC6 RPH3A SHANK2 EIF4G1 PAK1 DCHS1 PRKAR1A PAK3 CCAR2 SCRIB PRRC2A GOLGA2

6.86e-099631211828671696
Pubmed

Human transcription factor protein interaction networks.

RBM33 CCDC174 PEG10 KRI1 DIDO1 CHD8 XRCC1 RAD54L2 NDUFA8 STAT2 CDCA2 KMT2D NFATC4 DGKK EIF4G1 AUTS2 CCAR2 R3HDM1 TAF1L PRRC2A RAD21

2.24e-0814291212135140242
Pubmed

A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

TROAP DIDO1 CHD8 BCAR1 ZXDA EIF4G1 PAK1 PKN2 SCRIB PRRC2A GOLGA2 MRTFA CDC23

2.46e-085031211316964243
Pubmed

Identification of Human Neuronal Protein Complexes Reveals Biochemical Activities and Convergent Mechanisms of Action in Autism Spectrum Disorders.

CCSAP TROAP CHD8 CHD4 EIF4G1 DCHS1 PRRC2A

6.79e-08101121726949739
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

DIDO1 BRD3 CHD4 SMTN KMT2D EIF4G1 PPP1R18 CCAR2 PKN2 CDT1 SCRIB HSF1 PRRC2A MRTFA CDC23

8.65e-087741211515302935
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

PDGFRB JADE2 PEG10 DEF8 OBSL1 CHD4 RAD54L2 RPH3A PIK3R4 RBM22 TTC7B PIK3R1 EIF4G1 PAK1 PRKAR1A TTC17 SCRIB R3HDM1 PRRC2A

1.03e-0712851211935914814
Pubmed

Assembly of nuclear dimers of PI3K regulatory subunits is regulated by the Cdc42-activated tyrosine kinase ACK.

PIK3R1 PIK3R2 TNK2

4.09e-075121335429500
Pubmed

Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity.

OBSL1 CHD4 BCAR1 PIK3R4 NFATC4 PIK3R2 EIF4G1 PRKAR1A AUTS2 PAK3 TNK2 PKN2 TAF1L GOLGA2 CDC23

6.75e-079101211536736316
Pubmed

Transcription factor Foxp3 and its protein partners form a complex regulatory network.

KRI1 CHD8 CHD4 CBX4 EIF4G1 PPP1R18 CCAR2 TAF1L PRRC2A RAD21

7.31e-073701211022922362
Pubmed

The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.

NUMBL RBM33 DIDO1 CHD8 BRD3 CBX4 XRCC1 NDUFA8 AHDC1 PWWP2A RBM22 SHANK2 EIF4G1 PRKAR1A PPP1R18 TAF1L PRRC2A MED12 RAD21

1.04e-0614971211931527615
Pubmed

A High-Density Map for Navigating the Human Polycomb Complexome.

TROAP DIDO1 CHD4 CBX4 AHDC1 PWWP2A PRR14 KMT2D SOWAHA EIF4G1 AUTS2

1.36e-064951211127705803
Pubmed

PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.

RBM33 CCDC174 DIDO1 CHD8 CHD4 XRCC1 RAD54L2 AHDC1 RBM22 KMT2D CCAR2 DDX39A PRRC2A MED12 CDC23 RAD21

1.49e-0611031211634189442
Pubmed

Identification of Grb4/Nckbeta, a src homology 2 and 3 domain-containing adapter protein having similar binding and biological properties to Nck.

PDGFRB PAK1 PKN2

2.27e-068121310026169
Pubmed

The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.

KRI1 DIDO1 CHD4 XRCC1 PIK3R4 CDCA2 ZNF358 EIF4G1 CCAR2 DDX39A PRRC2A MED12 RAD21

2.60e-067591211335915203
Pubmed

Identification of SUMO Binding Proteins Enriched after Covalent Photo-Cross-Linking.

DIDO1 CHD8 CHD4 RAD54L2 EIF4G1 CCAR2 PKN2 DDX39A RAD21

2.61e-06332121932786267
Pubmed

Identification of proximal SUMO-dependent interactors using SUMO-ID.

NUMBL CHD8 CBX4 RAD54L2 AHDC1 SMTN RBM22 EIF4G1 PAK1 HSF1

3.73e-064441211034795231
Pubmed

Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.

NUMBL KRI1 BRD3 XRCC1 BCAR1 NCKAP5L CDCA2 KMT2D TTC7B PIK3R1 PPP1R18 CCAR2 SCRIB CSPP1 PRRC2A

3.86e-0610491211527880917
Pubmed

Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism.

CCSAP DIDO1 BRD3 TDG CHD4 XRCC1 BCAR1 TBC1D17 SMTN NFATC4 EIF4G1 PRRC2A MRTFA SEZ6

4.37e-069251211428986522
Pubmed

Large-scale concatenation cDNA sequencing.

ACD PEG10 WBP1L OBSL1 BRD3 AHDC1 SHANK2 SLC16A2 PRKAR1A PAK3 CDT1

5.06e-06568121119110174
Pubmed

A "double adaptor" method for improved shotgun library construction.

ACD PEG10 WBP1L OBSL1 BRD3 AHDC1 SHANK2 SLC16A2 PRKAR1A PAK3 CDT1

5.59e-06574121118619474
Pubmed

The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.

RBM33 CCDC174 KRI1 DIDO1 CHD8 CHD4 CBX4 XRCC1 NDUFA8 CDCA2 EIF4G1 TAF1L PRRC2A RAD21

6.20e-069541211436373674
Pubmed

Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.

CHD8 CHD4 PIK3R4 PAK1 MED12L PKN2 SCRIB DDX39A APBB1IP CDC23 RAD21

6.37e-065821211120467437
Pubmed

A novel role for the peptidyl-prolyl cis-trans isomerase Cyclophilin A in DNA-repair following replication fork stalling via the MRE11-RAD50-NBS1 complex.

RBM33 CCDC174 DIDO1 CHD8 NCCRP1 SMTN RBM22 MED12 GOLGA2 MRTFA

6.37e-064721211038943005
Pubmed

Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.

RBM33 CCDC174 OBSL1 CBX4 RAD54L2 BCAR1 NCKAP5L STAT2 RBM22 GOLGA2 CDC23

7.01e-065881211138580884
Pubmed

Structure of a specific peptide complex of the carboxy-terminal SH2 domain from the p85 alpha subunit of phosphatidylinositol 3-kinase.

PDGFRB PIK3R1

1.20e-05212128670861
Pubmed

Class IA phosphoinositide 3-kinase regulates heart size and physiological cardiac hypertrophy.

PIK3R1 PIK3R2

1.20e-052121216227599
Pubmed

Molecular mechanism behind rotavirus NSP1-mediated PI3 kinase activation: interaction between NSP1 and the p85 subunit of PI3 kinase.

PIK3R1 PIK3R2

1.20e-052121223221569
Pubmed

NMR trial models: experiences with the colicin immunity protein Im7 and the p85alpha C-terminal SH2-peptide complex.

PDGFRB PIK3R1

1.20e-052121211567151
Pubmed

Genetic reduction of class IA PI-3 kinase activity alters fetal hematopoiesis and competitive repopulating ability of hematopoietic stem cells in vivo.

PIK3R1 PIK3R2

1.20e-052121216239435
Pubmed

Acute inhibition of PI3K-PDK1-Akt pathway potentiates insulin secretion through upregulation of newcomer granule fusions in pancreatic β-cells.

PIK3R1 PIK3R2

1.20e-052121223077605
Pubmed

p21-Activated kinases 1 and 3 control brain size through coordinating neuronal complexity and synaptic properties.

PAK1 PAK3

1.20e-052121221115725
Pubmed

Interaction of the p85 subunit of PI 3-kinase and its N-terminal SH2 domain with a PDGF receptor phosphorylation site: structural features and analysis of conformational changes.

PDGFRB PIK3R1

1.20e-05212121330535
Pubmed

T-cell function is partially maintained in the absence of class IA phosphoinositide 3-kinase signaling.

PIK3R1 PIK3R2

1.20e-052121217164340
Pubmed

High content screening for inhibitors of protein interactions and post-translational modifications in primary cells by proximity ligation.

PDGFRB PIK3R1

1.20e-052121219864249
Pubmed

Sjögren's syndrome-like disease in mice with T cells lacking class 1A phosphoinositide-3-kinase.

PIK3R1 PIK3R2

1.20e-052121217071741
Pubmed

A Surveillance Mechanism Ensures Repair of DNA Lesions during Zygotic Reprogramming.

XRCC1 RAD21

1.20e-052121227916276
Pubmed

Association of p130CAS with phosphatidylinositol-3-OH kinase mediates adenovirus cell entry.

BCAR1 PIK3R1

1.20e-052121210799562
Pubmed

Intracellular movement of green fluorescent protein-tagged phosphatidylinositol 3-kinase in response to growth factor receptor signaling.

PIK3R1 PIK3R2

1.20e-052121210459020
Pubmed

Role of phosphoinositide 3-kinase regulatory isoforms in development and actin rearrangement.

PIK3R1 PIK3R2

1.20e-052121215767666
Pubmed

The p21-activated kinase PAK3 forms heterodimers with PAK1 in brain implementing trans-regulation of PAK3 activity.

PAK1 PAK3

1.20e-052121222815483
Pubmed

Two signaling molecules share a phosphotyrosine-containing binding site in the platelet-derived growth factor receptor.

PDGFRB PIK3R1

1.20e-05212127692233
Pubmed

Measurement of the binding of tyrosyl phosphopeptides to SH2 domains: a reappraisal.

PDGFRB PIK3R1

1.20e-05212127536927
Pubmed

Chromosomal localization of human p85 alpha, a subunit of phosphatidylinositol 3-kinase, and its homologue p85 beta.

PIK3R1 PIK3R2

1.20e-05212121314371
Pubmed

Anthrax lethal factor cleaves regulatory subunits of phosphoinositide-3 kinase to contribute to toxin lethality.

PIK3R1 PIK3R2

1.20e-052121232895527
Pubmed

Divergent regulation of hepatic glucose and lipid metabolism by phosphoinositide 3-kinase via Akt and PKClambda/zeta.

PIK3R1 PIK3R2

1.20e-052121216679292
Pubmed

Loss of class IA PI3K signaling in muscle leads to impaired muscle growth, insulin response, and hyperlipidemia.

PIK3R1 PIK3R2

1.20e-052121216679293
Pubmed

Group I p21-activated kinases facilitate Tax-mediated transcriptional activation of the human T-cell leukemia virus type 1 long terminal repeats.

PAK1 PAK3

1.20e-052121223622267
Pubmed

Dual specificity of Src homology 2 domains for phosphotyrosine peptide ligands.

PDGFRB PIK3R1

1.20e-05212129153411
Pubmed

Class IA phosphatidylinositol 3-kinase in pancreatic β cells controls insulin secretion by multiple mechanisms.

PIK3R1 PIK3R2

1.20e-052121221109194
Pubmed

Duplicated zinc finger protein genes on the proximal short arm of the human X chromosome: isolation, characterization and X-inactivation studies.

ZXDA ZXDB

1.20e-05212128268913
Pubmed

Solution structures and biophysical analysis of full-length group A PAKs reveal they are monomeric and auto-inhibited in cis.

PAK1 PAK3

1.20e-052121230858169
Pubmed

Interaction between Nef and phosphatidylinositol-3-kinase leads to activation of p21-activated kinase and increased production of HIV.

PIK3R1 PAK1

1.20e-052121212009866
Pubmed

Pan-cancer analysis on the role of PIK3R1 and PIK3R2 in human tumors.

PIK3R1 PIK3R2

1.20e-052121235395865
Pubmed

Tyrosine phosphorylation-dependent yeast two-hybrid system for the identification of the SH2 domain-binding proteins.

PDGFRB PIK3R1

1.20e-052121211710529
Pubmed

Expression of p21-activated kinases 1 and 3 is altered in the brain of subjects with depression.

PAK1 PAK3

1.20e-052121227474226
Pubmed

PI3K is involved in PDGF-beta receptor upregulation post-PDGF-BB treatment in mouse HSC.

PDGFRB PIK3R1

1.20e-052121216990448
Pubmed

Mechanism of influenza A virus NS1 protein interaction with the p85beta, but not the p85alpha, subunit of phosphatidylinositol 3-kinase (PI3K) and up-regulation of PI3K activity.

PIK3R1 PIK3R2

1.20e-052121218534979
Pubmed

Structure-activity studies of phosphorylated peptide inhibitors of the association of phosphatidylinositol 3-kinase with PDGF-beta receptor.

PDGFRB PIK3R1

1.20e-05212128564419
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

RALGDS JADE2 DIDO1 CHD8 ATG2A BAHD1 KBTBD11 MED12L AUTS2 RAD21

1.71e-055291211014621295
Pubmed

Socs1 binds to multiple signalling proteins and suppresses steel factor-dependent proliferation.

PDGFRB PIK3R1 PIK3R2

2.23e-0516121310022833
Pubmed

The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4.

ZBTB22 CHD8 CHD4 BCAR1 AHDC1 EIF4G1 SCRIB PRRC2A

2.24e-05332121837433992
Pubmed

Human Immunodeficiency Virus Type 1 Vpr Mediates Degradation of APC1, a Scaffolding Component of the Anaphase-Promoting Complex/Cyclosome.

PEG10 OBSL1 MRPS30 SCRIB PRRC2A MED12 CDC23

2.33e-05242121734011540
Pubmed

Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.

PEG10 DIDO1 CHD8 CBX4 XRCC1 STAT2 KMT2D MED12

2.71e-05341121832971831
Pubmed

Sox10 cooperates with the mediator subunit 12 during terminal differentiation of myelinating glia.

NFATC4 MED12L MED12

3.23e-0518121323575864
Pubmed

Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro.

ATG2A DNAJC6 IPCEF1 AUTS2

3.32e-055212149455477
Pubmed

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.

FAT3 OBSL1 CHD8 BRD3 CHD4 CBX4 SIPA1 NCKAP5L SOWAHA RASAL3 PIK3R1 PIK3R2 SCRIB CDC23

3.53e-0511161211431753913
Pubmed

The nuclear interactome of DYRK1A reveals a functional role in DNA damage repair.

TROAP KRI1 KMT2D SCRIB CDC23

3.59e-05106121531024071
Pubmed

Modulation of epithelial neoplasia and lymphoid hyperplasia in PTEN+/- mice by the p85 regulatory subunits of phosphoinositide 3-kinase.

PIK3R1 PIK3R2

3.59e-053121216006513
Pubmed

Altered cortical synaptic morphology and impaired memory consolidation in forebrain- specific dominant-negative PAK transgenic mice.

PAK1 PAK3

3.59e-053121215182717
Pubmed

p85α mediates NFAT3-dependent VEGF induction in the cellular UVB response.

NFATC4 PIK3R1

3.59e-053121223390317
Pubmed

Class 1A PI3K regulates vessel integrity during development and tumorigenesis.

PIK3R1 PIK3R2

3.59e-053121218621722
Pubmed

Specific phosphopeptide binding regulates a conformational change in the PI 3-kinase SH2 domain associated with enzyme activation.

PDGFRB PIK3R1

3.59e-05312128382612
Pubmed

The p85beta regulatory subunit of phosphoinositide 3-kinase has unique and redundant functions in B cells.

PIK3R1 PIK3R2

3.59e-053121219811262
Pubmed

T cell Ig and mucin domain-1-mediated T cell activation requires recruitment and activation of phosphoinositide 3-kinase.

PIK3R1 PIK3R2

3.59e-053121218453570
Pubmed

SHP-1 associates with both platelet-derived growth factor receptor and the p85 subunit of phosphatidylinositol 3-kinase.

PDGFRB PIK3R1

3.59e-05312129452499
Pubmed

Construction of an SH2 domain-binding site with mixed specificity.

PDGFRB PIK3R1

3.59e-05312127876130
Pubmed

High frequency of PIK3R1 and PIK3R2 mutations in endometrial cancer elucidates a novel mechanism for regulation of PTEN protein stability.

PIK3R1 PIK3R2

3.59e-053121221984976
Pubmed

A photoaffinity scan maps regions of the p85 SH2 domain involved in phosphoprotein binding.

PDGFRB PIK3R1

3.59e-05312127680644
Pubmed

The role of SRC-CAS interactions in cellular transformation: ectopic expression of the carboxy terminus of CAS inhibits SRC-CAS interaction but has no effect on cellular transformation.

BCAR1 PIK3R1

3.59e-053121210487518
Pubmed

PERK utilizes intrinsic lipid kinase activity to generate phosphatidic acid, mediate Akt activation, and promote adipocyte differentiation.

PIK3R1 PIK3R2

3.59e-053121222493067
Pubmed

The protein kinase Pak3 positively regulates Raf-1 activity through phosphorylation of serine 338.

PAK1 PAK3

3.59e-05312129823899
Pubmed

A novel interaction between fibroblast growth factor receptor 3 and the p85 subunit of phosphoinositide 3-kinase: activation-dependent regulation of ERK by p85 in multiple myeloma cells.

PIK3R1 PIK3R2

3.59e-053121219286672
Pubmed

Phosphorylation sites in the PDGF receptor with different specificities for binding GAP and PI3 kinase in vivo.

PDGFRB PIK3R1

3.59e-05312121314164
Pubmed

PAK1 regulates ATXN1 levels providing an opportunity to modify its toxicity in spinocerebellar ataxia type 1.

PAK1 PAK3

3.59e-053121229860311
Pubmed

p85 Associates with unphosphorylated PTEN and the PTEN-associated complex.

PIK3R1 PIK3R2

3.59e-053121219635806
Pubmed

MED12 interacts with the heat-shock transcription factor HSF1 and recruits CDK8 to promote the heat-shock response in mammalian cells.

HSF1 MED12

3.59e-053121234056708
Pubmed

Stimulation of CD28 triggers an association between CD28 and phosphatidylinositol 3-kinase in Jurkat T cells.

PIK3R1 PIK3R2

3.59e-05312127509360
Pubmed

Transforming activity of receptor tyrosine kinase tyro3 is mediated, at least in part, by the PI3 kinase-signaling pathway.

PIK3R1 PIK3R2

3.59e-053121210627473
Pubmed

Multisite autophosphorylation of p21-activated protein kinase gamma-PAK as a function of activation.

PAK1 PAK3

3.59e-053121210075701
Pubmed

Interactions between SH2 domains and tyrosine-phosphorylated platelet-derived growth factor beta-receptor sequences: analysis of kinetic parameters by a novel biosensor-based approach.

PDGFRB PIK3R1

3.59e-05312128388538
Pubmed

The Rac GTPase effector p21-activated kinase is essential for hematopoietic stem/progenitor cell migration and engraftment.

PAK1 PAK3

3.59e-053121223335370
Pubmed

Group I Paks as therapeutic targets in NF2-deficient meningioma.

PAK1 PAK3

3.59e-053121225596744
Pubmed

HIV-1 Nef associated PAK and PI3-kinases stimulate Akt-independent Bad-phosphorylation to induce anti-apoptotic signals.

PIK3R1 PAK1

3.59e-053121211689886
Pubmed

Hyperosmotic stress inhibits insulin receptor substrate-1 function by distinct mechanisms in 3T3-L1 adipocytes.

PIK3R1 PIK3R2

3.59e-053121212730242
Pubmed

The four mammalian splice variants encoded by the p21-activated kinase 3 gene have different biological properties.

PAK1 PAK3

3.59e-053121218507705
Pubmed

Activation of the Eck receptor protein tyrosine kinase stimulates phosphatidylinositol 3-kinase activity.

PIK3R1 PIK3R2

3.59e-05312127982920
Pubmed

Porocarcinomas with PAK1/2/3 fusions: a series of 12 cases.

PAK1 PAK3

3.59e-053121238785043
InteractionH4C3 interactions

OBSL1 BRD3 CHD4 HSF1 RAD21

1.13e-05501195int:H4C3
InteractionNCK1 interactions

PDGFRB SCARF2 BCAR1 PIK3R1 PAK1 PAK3 TNK2 PKN2 DDX39A

1.47e-052441199int:NCK1
InteractionH4C4 interactions

OBSL1 BRD3 CHD4 RAD21

2.45e-05291194int:H4C4
InteractionH4C16 interactions

OBSL1 BRD3 CHD4 CBX4 PARP10 PAK1 RAD21

3.34e-051521197int:H4C16
InteractionMEN1 interactions

JADE2 PEG10 KRI1 DIDO1 CHD8 CHD4 CBX4 XRCC1 AHDC1 STAT2 KMT2D EIF4G1 PRKAR1A PRRC2A MED12 GOLGA2 CDC23 RAD21

3.34e-05102911918int:MEN1
InteractionCHAF1B interactions

OBSL1 BRD3 CHD4 BCAR1 PWWP2A EIF4G1 HSF1

4.28e-051581197int:CHAF1B
InteractionFBLN5 interactions

TROAP OBSL1 CHD8 CBX4 RAD54L2 ZXDB R3HDM1

4.46e-051591197int:FBLN5
InteractionH4C5 interactions

OBSL1 BRD3 CHD4 RAD21

4.67e-05341194int:H4C5
CytobandEnsembl 112 genes in cytogenetic band chr19q13

NUMBL ODAD1 XRCC1 NCCRP1 TBC1D17 SELENOV DLL3 MAMSTR BLOC1S3 FBXO27 LILRB5 ZNF541

7.75e-05119212112chr19q13
Cytoband12q13.12

TROAP NCKAP5L KMT2D

1.41e-0438121312q13.12
Cytoband19q13.33

ODAD1 TBC1D17 MAMSTR ZNF541

1.85e-04106121419q13.33
Cytoband8q24.3

PARP10 SCRIB HSF1 PPP1R16A

2.37e-0411312148q24.3
Cytoband6p21.3

ZBTB22 IER3 PPP1R18 PRRC2A TNXB

5.47e-0425012156p21.3
Cytoband19q13.2

XRCC1 NCCRP1 SELENOV FBXO27

9.64e-04164121419q13.2
Cytoband5q33.1

PDGFRB RBM22

2.15e-032612125q33.1
CytobandEnsembl 112 genes in cytogenetic band chr8q24

PARP10 SCRIB HSF1 PPP1R16A RAD21

2.57e-033551215chr8q24
GeneFamilyAtaxins|Trinucleotide repeat containing

NUMBL KMT2D MED12

1.54e-0425763775
GeneFamilyPHD finger proteins

JADE2 DIDO1 CHD4 KMT2D

5.60e-049076488
GeneFamilyArmadillo repeat containing|Protein phosphatase 1 regulatory subunits

PPP1R3G CDCA2 PPP1R18 PPP1R35 PPP1R16A

9.90e-04181765694
GeneFamilyWiskott-Aldrich Syndrome protein family

WASHC1 WASH2P

2.01e-031676214
GeneFamilyCadherin related

FAT3 DCHS1

2.28e-031776224
CoexpressionGSE11924_TFH_VS_TH17_CD4_TCELL_UP

AMPD3 ACD CHD8 CBX4 ZXDB SMTN KMT2D PPP1R35

4.15e-061991218M3156
CoexpressionTHAKAR_PBMC_INACTIVATED_INFLUENZA_AGE_21_30YO_RESPONDERS_28DY_DN

RBM33 WASHC1 DEF8 DIDO1 ATG2A RAD54L2 APOBR PLEKHM1 STAT2 PARP10 PRR14 RASAL3 PIK3R2 PPP1R18 TNK2 PPP1R35

4.32e-0690512116M40865
CoexpressionTABULA_MURIS_SENIS_BRAIN_NON_MYELOID_NEURON_AGEING

RALGDS PLVAP NUMBL ZBTB22 OBSL1 DIDO1 CHD8 CHD4 PIK3R4 RBM22 AUTS2 ZFHX2 TNK2 CCAR2 PPP1R35 SEZ6

8.37e-0695412116MM3689
CoexpressionGINESTIER_BREAST_CANCER_ZNF217_AMPLIFIED_DN

RBM33 RAD54L2 NCKAP5L KMT2D ZNF358 TNK2 CCAR2 TTC17 PRRC2A

2.82e-053381219M17094
CoexpressionTHAKAR_PBMC_INACTIVATED_INFLUENZA_AGE_21_30YO_RESPONDERS_7DY_DN

RALGDS RBM33 WASHC1 DEF8 DIDO1 CBX4 ATG2A RAD54L2 RASAL3 PIK3R2 PPP1R18 TNK2

3.84e-0563412112M40866
CoexpressionGSE22589_SIV_VS_HIV_AND_SIV_INFECTED_DC_DN

CHD4 SIPA1 BAHD1 ZXDB PPP1R18 PDIA2 RAD21

4.11e-052001217M7799
ToppCellwk_15-18-Hematologic-Myeloid-Basophil|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

CCSAP AMPD3 CBX4 APOBR PLEKHM1 KBTBD11 MRTFA

8.40e-0718812173638d85452de15a060146628fbbad9d2a36feb13
ToppCellIPF-Myeloid-cDC1|World / Disease state, Lineage and Cell class

PPP1R3G PAK1 MED12L AUTS2 PAK3 FBXO27

1.19e-051861216962c2dada19185628ead77c32fcb07fa95114247
ToppCellControl-Myeloid-cDC1|Control / Disease state, Lineage and Cell class

PPP1R3G PAK1 MED12L AUTS2 PAK3 FBXO27

1.19e-051861216b05c394aa3573ba855abc3066739ca193883b0c3
ToppCellIPF-Myeloid-cDC1|Myeloid / Disease state, Lineage and Cell class

PPP1R3G PAK1 MED12L AUTS2 PAK3 FBXO27

1.27e-05188121647bb6caf84f70a1cda7d09803afdfd5182772e66
ToppCellIPF-Myeloid-cDC1|IPF / Disease state, Lineage and Cell class

PPP1R3G PAK1 MED12L AUTS2 PAK3 FBXO27

1.27e-0518812162331a2bae1383820d598e93aa86c75b101069bac
ToppCellMS-CD8-CD4_Treg|MS / Condition, Cell_class and T cell subcluster

ZBTB22 BAHD1 PLEKHM1 PIK3R1 R3HDM1 PPP1R16A

1.27e-0518812162f0e2c7d79ee2d69a5d908c0247dc950c056c30a
ToppCelldroplet-Pancreas-PANCREAS-30m-Endothelial-nan|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PLVAP CAVIN3 SIPA1 NCKAP5L IER3 DCHS1

1.39e-051911216471205494b91be69926dc8159376132bcea0d9b5
ToppCellCOPD-Myeloid-cDC1|COPD / Disease state, Lineage and Cell class

PPP1R3G PAK1 MED12L AUTS2 PAK3 FBXO27

1.43e-051921216bd3d00b094d92463b06023361a71240851a542b8
ToppCellSmart-start-Cell-Wel_seq-Neoplastic-Stem-like-NPC-like-NPC-like_Prolif|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

TROAP PEG10 SMTN CDCA2 DDX39A RAD21

1.43e-051921216849ac3c115e6f913e68ca050c308bc4c32cf662b
ToppCelldroplet-Liver-LIVER-NPC-1m-Mesenchymal-hepatic_stellate_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PLVAP PDGFRB SCARF2 CAVIN3 NFATC4 TNXB

1.51e-051941216415801a3dfacf05f2b603fb424df3d045190a812
ToppCelldroplet-Liver-LIVER-NPC-1m-Mesenchymal-hepatic_stellate_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PLVAP PDGFRB SCARF2 CAVIN3 NFATC4 TNXB

1.51e-051941216256cb33ec90328f2704921fb0fe0fd9812e138b0
ToppCelldroplet-Liver-LIVER-NPC-1m-Mesenchymal|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PLVAP PDGFRB SCARF2 CAVIN3 NFATC4 TNXB

1.51e-0519412167942bc83c1bdca687795b91aa232824d603f9b09
ToppCellBronchus_Control_(B.)-Epithelial-TX-AT2-2|Bronchus_Control_(B.) / Sample group, Lineage and Cell type

CBX4 ATG2A ZXDA ZXDB SMTN MAMSTR

1.51e-0519412165bfc26668fa8f109f2ebc0d5fd98ab5bd219e62c
DiseaseSquamous cell carcinoma of esophagus

FAT3 DIDO1 XRCC1 KMT2D TNXB

3.46e-05951145C0279626
DiseasePhyllodes Tumor

KMT2D MED12

1.47e-0451142C0010701
DiseaseMalignant Cystosarcoma Phyllodes

KMT2D MED12

1.47e-0451142C0600066
DiseaseGastric Adenocarcinoma

PDGFRB BRD3 TNK2

7.08e-04451143C0278701
Diseasereticulocyte measurement

AMPD3 PLVAP BRD3 SIPA1 PIK3R1 EIF4G1 PRKAR1A PKN2 CDT1 DDX39A MED12 APBB1IP

7.83e-04105311412EFO_0010700
Diseasesmoking cessation

RBM33 JADE2 WBP1L DEF8 MRPS30 AUTS2

1.68e-033251146EFO_0004319
Diseaserespiratory symptom change measurement, response to placebo

CDCA2 PKN2

1.94e-03171142EFO_0008344, EFO_0010068
DiseaseMalignant neoplasm of endometrium

PIK3R2 RAD21

2.17e-03181142C0007103
DiseaseCarcinoma in situ of endometrium

PIK3R2 RAD21

2.17e-03181142C0346191
Diseaseovulation

PLEKHM1 PRRC2A

2.42e-03191142GO_0030728
Diseasereticulocyte count

AMPD3 PLVAP BRD3 SIPA1 RPH3A PIK3R1 PRKAR1A CDT1 DDX39A MED12 APBB1IP

2.43e-03104511411EFO_0007986
Diseaserenal cell carcinoma (is_implicated_in)

PDGFRB XRCC1 PAK1

2.44e-03691143DOID:4450 (is_implicated_in)
DiseaseProstatic Neoplasms

JADE2 XRCC1 BCAR1 KMT2D PIK3R1 PIK3R2 TAF1L MED12

2.74e-036161148C0033578
DiseaseMalignant neoplasm of prostate

JADE2 XRCC1 BCAR1 KMT2D PIK3R1 PIK3R2 TAF1L MED12

2.74e-036161148C0376358
DiseaseEndometrial Carcinoma

CHD4 PIK3R2 RAD21

2.76e-03721143C0476089
Diseasefumarate measurement

IPCEF1 PPP1R16A

2.96e-03211142EFO_0010480
DiseaseMalignant neoplasm of breast

PRRG1 SCARF2 BCAR1 NDUFA8 FSCB PIK3R4 KMT2D PAK1 PRRC2A MED12 ZNF541

2.99e-03107411411C0006142
Diseasetonsillectomy risk measurement

RPH3A PARP10 PIK3R1 CSPP1 TNXB

3.44e-032601145EFO_0007924
DiseaseLiver carcinoma

PLVAP TROAP DNAJC6 CDCA2 KBTBD11 CDT1 LILRB5

3.60e-035071147C2239176

Protein segments in the cluster

PeptideGeneStartEntry
PEEVPAPAPAQEPVQ

TDG

41

Q13569
QETDTDLPEAPPPPL

CCAR2

491

Q8N163
PDEPVEAPALPAPAA

BRD3

416

Q15059
PLAELQPPPPITEED

CDC23

66

Q9UJX2
PPAAGDEPPDPNLFI

CHD8

1861

Q9HCK8
PALEPTLEPEPPQDT

CAVIN3

226

Q969G5
LVLAAPPPDSPPAED

BCAR1

346

P56945
EEEPQAPQESTPAPP

DDX39A

16

O00148
DDLPPPPADPVLDLP

APBB1IP

126

Q7Z5R6
PDIEPAALPQPPATE

CDT1

341

Q9H211
PPPPVEPATQEEAER

CCSAP

81

Q6IQ19
TEQPGAPAPDLPLPD

DLL3

91

Q9NYJ7
AQALEPPSPEPEPQL

AHDC1

261

Q5TGY3
LPPPEALPADNKPEE

RAD54L2

351

Q9Y4B4
YEELPAQEEPPEPPL

ATG2A

236

Q2TAZ0
AFVPEQARPPPPLED

TNK2

671

Q07912
PPLPQEDPYCLDDAP

AMPD3

201

Q01432
QDLEPEDPLPPEAPD

IGDCC4

1151

Q8TDY8
QPLPDPAPLPELEFE

SLC16A2

56

P36021
PAPAPAPELDPFEAQ

NUMBL

566

Q9Y6R0
NEDFCPPPPNPEDII

CHM

601

P24386
PPPPNPEDIILDGDS

CHM

606

P24386
EESPPPPAPEISQEN

R3HDM1

86

Q15032
QEAPELEPEPELEPP

RASAL3

106

Q86YV0
LPGALPPPPAAEEEA

RBM22

331

Q9NW64
APPPPAEQEEQALSP

RBM33

836

Q96EV2
PVELPPEEPPNICQL

RAD21

501

O60216
VHQPPESPPADPDEA

OBSL1

226

O75147
ESPPADPDEAPAPVV

OBSL1

231

O75147
PPDLAERDPAAPVPV

DCHS1

1321

Q96JQ0
EEDENEPPPVIAPRP

PAK3

196

O75914
LSEASPEPIPEPCPE

DGKK

46

Q5KSL6
EPATEPAPEPATEPA

DGKK

96

Q5KSL6
ATEPAPEPAPEPATE

DGKK

106

Q5KSL6
AEEGVPAPLPPEDAP

IER3

101

P46695
QPLPLPPEEEEEEPT

MED12L

1726

Q86YW9
DDPCEDPGPTPPVQL

NCKAP5L

1216

Q9HCH0
VQPPPAEEAPLVEFP

FSCB

316

Q5H9T9
EESPSEEPPAEILPP

FSCB

356

Q5H9T9
APAEVQPPPAEEAPA

FSCB

606

Q5H9T9
PAEEAPAEVQPPPAE

FSCB

626

Q5H9T9
PAEVQPPPAEEAPAE

FSCB

631

Q5H9T9
EAPAEVQPPPAEEAP

FSCB

641

Q5H9T9
VQPPPAEEAPAEVQP

FSCB

646

Q5H9T9
APAEVQPPPAEEAPA

FSCB

666

Q5H9T9
APDPEASPLAEPPQE

LACTB

71

P83111
AAPEAPELPEPAQPS

NCCRP1

51

Q6ZVX7
ESPPPLAPETPDEAA

JADE2

671

Q9NQC1
ELLSPQEPPRPPEAE

HSF1

441

Q00613
QEPPRPPEAENSSPD

HSF1

446

Q00613
PVPNPQPIDPASLEE

PLVAP

406

Q9BX97
PAIEDDVLPPPSQLP

CSPP1

1111

Q1MSJ5
DPDLVQRTEAPPQPP

AUTS2

321

Q8WXX7
AAAAPPPPIEEECPE

PEG10

66

Q86TG7
PESPPAQEEEAPVSP

KRI1

626

Q8N9T8
PEDEEPPAPTLLEPE

MED12

1746

Q93074
ATEPPPSQEREPPAE

LILRB5

566

O75023
VLPTEEPPEEPAAPF

PDIA2

496

Q13087
PDLAEQFAPPDIAPP

PIK3R1

116

P27986
PPEPPAGPSEVEQQL

GOLGA2

451

Q08379
APLQPPDTLEDPPGF

ODAD1

456

Q96M63
DDDATPPPVIAPRPE

PAK1

181

Q13153
LPDLPEQFSPPDVAP

PIK3R2

111

O00459
EQEDPEIAAETPPPP

IPCEF1

156

Q8WWN9
QDQLPPPLPEDFPDQ

FAT3

4416

Q8TDW7
QEPAAPPPPEDVDLL

DNAJC6

486

O75061
ERPADLPPAAALPQP

CBX4

446

O00257
GDAEADPLEPPPPQQ

DIDO1

41

Q9BTC0
ADEADELPPDLPKPP

BAHD1

86

Q8TBE0
EPEPEPEPTAAPRDL

BLOC1S3

66

Q6QNY0
EPEVESSPELAPPPA

EIF4G1

371

Q04637
PALELEPAPEQDPAP

RALGDS

331

Q12967
DQVEPDDPLPPIPLD

MAMSTR

316

Q6ZN01
QSPVPEPLPQPDFDD

CDCA2

436

Q69YH5
PEEALPELPPGEPEF

DEF8

101

Q6ZN54
DSREDEISPPPPNPV

PRKAR1A

76

P10644
NLPEGEIPPPQDPSE

CCDC174

146

Q6PII3
PEPEPEEALDLSQLP

FBXO27

16

Q8NI29
NSLPPPHPENEEDPE

CHD4

26

Q14839
QEEEAVELQPPPPAP

PPP1R18

416

Q6NYC8
EELGPEPEVPSAPNP

PPP1R18

561

Q6NYC8
PRPDPSPEIEGDLQP

NDUFA8

146

P51970
DSPLEPQDEPEPEPQ

PDGFRB

1061

P09619
SLLEQPPLEAEEPPD

PARP10

686

Q53GL7
PDQPEEPPEAPQGCL

PLEKHM1

641

Q9Y4G2
EPEPEPEPEPALDLA

MRPS30

126

Q9NP92
EFLELPPPQEPLEPS

RTL3

181

Q8N8U3
PEQPPAPEEREEPPL

PWWP2A

121

Q96N64
APEEREEPPLPQPVA

PWWP2A

126

Q96N64
PAAARQPPPPEEEEE

RPH3A

366

Q9Y2J0
PVSQPVPEPDLPCDL

STAT2

781

P52630
ISPTPEPPAALEDNP

NFATC4

121

Q14934
APPPPPEQCLADDEI

TAF1L

316

Q8IZX4
EEAAAVPGPPPEPQV

PPP1R35

16

Q8TAP8
EPPFQPSALPADPLE

PRR14

201

Q9BWN1
PQDSPQPLPAPEEEE

RETREG2

471

Q8NC44
TPETEPEEPAQAPPA

PRRC2A

541

P48634
TGAELRPPPPEEDNP

PPP1R16A

391

Q96I34
PQLQVDLDLDPDPDP

SPATA32

46

Q96LK8
PDPDPDPELEIGQVP

SPATA32

56

Q96LK8
LGLPAEEPEPAFPPV

SIPA1

96

Q96FS4
ELQPEPLEPQQPEAP

PPP1R3G

266

B7ZBB8
PEPPAPERALSPAEL

SCRIB

1476

Q14160
EPAPELPLLPEEDPE

SELENOV

156

P59797
LDFDLEPEPPPAPPR

PKN2

566

Q16513
PGELPEDAVSPPQAP

EXTL1

61

Q92935
ERACPEEPAAPSPEP

KBTBD11

96

O94819
EALQPEPEPVPAPQL

MRTFA

626

Q969V6
DPQAPEPPSQLRPDE

SHANK2

1056

Q9UPX8
TQGPELPPPDPALQD

ACD

246

Q96AP0
QEEPPAPNPPEEELS

APOBR

1026

Q0VD83
LPDCPPPEDPAIAQL

PIK3R4

756

Q99570
QPEGAASDLPPPPDD

TBC1D17

241

Q9HA65
LLLAEPAEPAPAPAP

ZXDB

231

P98169
PEPDAQAEDVAPPPT

ZFHX2

1131

Q9C0A1
PDAEELPAAPPPSAV

SOWAHA

291

Q2M3V2
RDPEVPTVPAEAPAP

SCARF2

576

Q96GP6
PPLPPPQQPQAEEDE

WASH2P

446

Q6VEQ5
ADAPLPEEPSLPDLP

TRPC5OS

51

A6NMA1
EPSTEAPEPPEEPLL

TNXB

2941

P22105
LAPEAPEPPEEPRLG

TNXB

3546

P22105
PPLPPPQQPQAEEDE

WASHC1

446

A8K0Z3
EQLEVPEPCPPAEPG

TROAP

606

Q12815
EELRPALPFQPDPPA

SEZ6

86

Q53EL9
DTESPVPPDPEQPDC

TTC17

146

Q96AE7
LEEAPEPPCPEPRQS

PRR33

201

A8MZF0
LNIITPPPPPDEVFD

PRRG1

126

O14668
EPAEPAPAPAPQEEA

ZXDA

231

P98168
PLEDPPCQSPLDDPL

TTC7B

281

Q86TV6
PPDLPVPELPDFFQG

XRCC1

531

P18887
LPALPVPLPDPSNEE

WNK4

771

Q96J92
PPSIADPDPSDLPVD

WBP1L

171

Q9NX94
PASPEPPLEPAEAQC

SMTN

211

P53814
CPAPTPLVPQDPDLE

ZBTB22

306

O15209
GAPDPPEPEPDTALL

ZNF541

361

Q9H0D2
PNPEDLDPVSEDPEP

ZNF358

31

Q9NW07
SPVPEEPCLSPQPEE

KMT2D

816

O14686