Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	phosphopyruvate hydratase activity	ENO1 ENO2 ENO3	8.22e-07	4	119	3	GO:0004634
GeneOntologyBiologicalProcess	regulation of postsynapse assembly	CARMIL3 NRXN2 GNA13 AFDN PPP1R9B	5.33e-06	44	119	5	GO:0150052
GeneOntologyBiologicalProcess	postsynapse assembly	CARMIL3 NRXN1 NRXN2 GNA13 AFDN PPP1R9B	1.64e-05	93	119	6	GO:0099068
GeneOntologyCellularComponent	phosphopyruvate hydratase complex	ENO1 ENO2 ENO3	6.81e-07	4	117	3	GO:0000015
GeneOntologyCellularComponent	cell body	CYP11A1 SLC1A2 KIF3A ITPR3 SLC6A1 BMPR2 RACK1 NRXN1 PYCARD LRP1 ASTN1 PPP1R9B C4A C4B ENO2 ALK	6.08e-05	929	117	16	GO:0044297
GeneOntologyCellularComponent	axon	BCR SLC1A2 KIF3A SLC6A1 BMPR2 NRXN1 CNTN5 LRP1 AFDN PPP1R9B C4A C4B ENO1 ENO2 ALK	1.35e-04	891	117	15	GO:0030424
GeneOntologyCellularComponent	somatodendritic compartment	CYP11A1 BCR SLC1A2 KIF3A ITPR3 SLC6A1 BMPR2 RACK1 NRXN1 PYCARD LRP1 ASTN1 AFDN PPP1R9B C4A C4B ENO2 ALOX5	1.60e-04	1228	117	18	GO:0036477
GeneOntologyCellularComponent	neuronal cell body	CYP11A1 KIF3A ITPR3 SLC6A1 BMPR2 RACK1 NRXN1 PYCARD LRP1 ASTN1 PPP1R9B C4A C4B ENO2	2.39e-04	835	117	14	GO:0043025
GeneOntologyCellularComponent	symbiont cell surface	C4A C4B	8.51e-04	8	117	2	GO:0106139
Domain	Enolase_N	ENO1 ENO2 ENO3	2.16e-07	3	113	3	PF03952
Domain	Enolase	ENO1 ENO2 ENO3	2.16e-07	3	113	3	IPR000941
Domain	Enolase_C	ENO1 ENO2 ENO3	2.16e-07	3	113	3	IPR020810
Domain	Enolase_N	ENO1 ENO2 ENO3	2.16e-07	3	113	3	IPR020811
Domain	Enolase_CS	ENO1 ENO2 ENO3	2.16e-07	3	113	3	IPR020809
Domain	Enolase_C	ENO1 ENO2 ENO3	2.16e-07	3	113	3	PF00113
Domain	Enolase_N	ENO1 ENO2 ENO3	2.16e-07	3	113	3	SM01193
Domain	Enolase_C	ENO1 ENO2 ENO3	2.16e-07	3	113	3	SM01192
Domain	ENOLASE	ENO1 ENO2 ENO3	2.16e-07	3	113	3	PS00164
Domain	-	ENO1 ENO2 ENO3	8.59e-07	4	113	3	3.30.390.10
Domain	-	ENO1 ENO2 ENO3	8.59e-07	4	113	3	3.20.20.120
Domain	Enolase_C-like	ENO1 ENO2 ENO3	8.59e-07	4	113	3	IPR029065
Domain	Enolase_N-like	ENO1 ENO2 ENO3	8.59e-07	4	113	3	IPR029017
Domain	MULTICOPPER_OXIDASE2	CP HEPHL1	1.08e-04	3	113	2	PS00080
Domain	Cu-oxidase_2	CP HEPHL1	2.16e-04	4	113	2	IPR011706
Domain	Cu-oxidase_2	CP HEPHL1	2.16e-04	4	113	2	PF07731
Domain	Anaphylatoxin_comp_syst	C4A C4B	3.59e-04	5	113	2	IPR018081
Domain	-	RBM15B XRCC6	3.59e-04	5	113	2	2.40.290.10
Domain	Anaphylatoxn_comp_syst_dom	C4A C4B	3.59e-04	5	113	2	IPR001840
Domain	Cu-oxidase_3	CP HEPHL1	3.59e-04	5	113	2	IPR011707
Domain	MULTICOPPER_OXIDASE1	CP HEPHL1	3.59e-04	5	113	2	PS00079
Domain	Cu_oxidase_CS	CP HEPHL1	3.59e-04	5	113	2	IPR033138
Domain	SPOC-like_C_dom	RBM15B XRCC6	3.59e-04	5	113	2	IPR016194
Domain	Cu-oxidase_3	CP HEPHL1	3.59e-04	5	113	2	PF07732
Domain	Cu_oxidase_Cu_BS	CP HEPHL1	5.36e-04	6	113	2	IPR002355
Domain	ANATO	C4A C4B	7.47e-04	7	113	2	SM00104
Domain	ANAPHYLATOXIN_2	C4A C4B	7.47e-04	7	113	2	PS01178
Domain	ANAPHYLATOXIN_1	C4A C4B	7.47e-04	7	113	2	PS01177
Domain	Syndecan	NRXN1 NRXN2	7.47e-04	7	113	2	PF01034
Domain	ANATO	C4A C4B	7.47e-04	7	113	2	PF01821
Domain	Syndecan/Neurexin_dom	NRXN1 NRXN2	7.47e-04	7	113	2	IPR027789
Domain	Anaphylatoxin/fibulin	C4A C4B	7.47e-04	7	113	2	IPR000020
Domain	MacrogloblnA2_thiol-ester-bond	C4A C4B	9.92e-04	8	113	2	IPR019565
Domain	Thiol-ester_cl	C4A C4B	9.92e-04	8	113	2	PF10569
Domain	MacrogloblnA2_CS	C4A C4B	9.92e-04	8	113	2	IPR019742
Domain	LAM_G_DOMAIN	CELSR1 NRXN1 NRXN2	1.56e-03	38	113	3	PS50025
Domain	A2M	C4A C4B	1.58e-03	10	113	2	PF00207
Domain	A2M_N_2	C4A C4B	1.58e-03	10	113	2	IPR011625
Domain	A2M_comp	C4A C4B	1.58e-03	10	113	2	IPR011626
Domain	A2M_recep	C4A C4B	1.58e-03	10	113	2	PF07677
Domain	A2M_comp	C4A C4B	1.58e-03	10	113	2	PF07678
Domain	A2M_N	C4A C4B	1.58e-03	10	113	2	PF01835
Domain	A2M_N	C4A C4B	1.58e-03	10	113	2	IPR002890
Domain	A-macroglobulin_rcpt-bd	C4A C4B	1.58e-03	10	113	2	IPR009048
Domain	ALPHA_2_MACROGLOBULIN	C4A C4B	1.58e-03	10	113	2	PS00477
Domain	A2M_N_2	C4A C4B	1.58e-03	10	113	2	PF07703
Domain	Macroglobln_a2	C4A C4B	1.58e-03	10	113	2	IPR001599
Domain	G-protein_beta_WD-40_rep	WSB1 FBXW10B FBXW10 RACK1	1.76e-03	85	113	4	IPR020472
Domain	Laminin_G_2	CELSR1 NRXN1 NRXN2	1.81e-03	40	113	3	PF02210
Domain	LamG	CELSR1 NRXN1 NRXN2	2.38e-03	44	113	3	SM00282
Domain	-	CP HEPHL1	3.15e-03	14	113	2	2.60.40.420
Domain	Neurexin-like	NRXN1 NRXN2	3.15e-03	14	113	2	IPR003585
Domain	4.1m	NRXN1 NRXN2	3.15e-03	14	113	2	SM00294
Domain	WD40_repeat_CS	WSB1 FBXW10B FBXW10 RACK1 WDR72	3.22e-03	164	113	5	IPR019775
Domain	-	WSB1 FBXW10B FBXW10 EDC4 SEMA6D RACK1 WDR72	4.14e-03	333	113	7	2.130.10.10
Domain	WD40/YVTN_repeat-like_dom	WSB1 FBXW10B FBXW10 EDC4 SEMA6D RACK1 WDR72	4.28e-03	335	113	7	IPR015943
Domain	C345C	C4A C4B	4.65e-03	17	113	2	SM00643
Domain	Terpenoid_cyclase/PrenylTrfase	C4A C4B	5.21e-03	18	113	2	IPR008930
Domain	Laminin_G	CELSR1 NRXN1 NRXN2	5.23e-03	58	113	3	IPR001791
Domain	NTR	C4A C4B	5.80e-03	19	113	2	PF01759
Domain	Netrin_module_non-TIMP	C4A C4B	5.80e-03	19	113	2	IPR018933
Domain	WD40	WSB1 FBXW10B FBXW10 EDC4 RACK1 WDR72	5.81e-03	268	113	6	SM00320
Pubmed	Solution structure of AF-6 PDZ domain and its interaction with the C-terminal peptides from Neurexin and Bcr.	BCR NRXN1 AFDN	4.01e-08	3	120	3	15684424
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	DDX19A TBC1D15 ACADVL ACLY RPS5 BTAF1 IDH3A EDC4 ITPR3 RACK1 PRPF3 GNA13 TMPO AFDN ENO1 XRCC6 RBM17	9.09e-08	1024	120	17	24711643
Pubmed	A Moonlighting Human Protein Is Involved in Mitochondrial Import of tRNA.	ENO1 ENO2 ENO3	1.60e-07	4	120	3	25918939
Pubmed	ARHGAP24 represses β-catenin transactivation-induced invasiveness in hepatocellular carcinoma mainly by acting as a GTPase-independent scaffold.	ARHGAP24 ACLY RPS5 NCAPG2 ZNF557 PRPF3 PPP1R9B ENO1 ENO2 ENO3 XRCC6	5.05e-07	451	120	11	36168627
Pubmed	Cathepsin X cleaves the C-terminal dipeptide of alpha- and gamma-enolase and impairs survival and neuritogenesis of neuronal cells.	ENO1 ENO2 ENO3	7.95e-07	6	120	3	19433310
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	NEBL ACLY ANKRD26 BTAF1 EDC4 WNK1 NEK1 RACK1 PRPF3 ZMAT2 TMPO PPP1R9B ENO1 XRCC6 RBM17	8.38e-07	934	120	15	33916271
Pubmed	A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.	SGCB MYOZ2 ANKRD26 WNK1 KIF3A RACK1 RBM5 ENO1 ENO3 MED13 XRCC6	1.30e-06	497	120	11	23414517
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	VAPA EVL ACADVL IDH3A EDC4 BCR SLC1A2 SLC6A1 RACK1 NRXN1 ASTN1 AFDN PPP1R9B ENO1 ALDH6A1 RBM17	2.01e-06	1139	120	16	36417873
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	EVL ACLY RPS5 IDH3A EDC4 BCR SLC1A2 KIF3A SLC6A1 RACK1 NRXN2 TMPO AFDN PPP1R9B C4A C4B ENO2 GOLGA3	2.08e-06	1431	120	18	37142655
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	VAPA EVL ACADVL RPS5 ANKRD26 CCDC150 NRXN1 GNA13 ZMAT2 RBM5 TMPO PPP1R9B ATM ENO1 DNAH8 MED13 XRCC6 CCDC158	2.32e-06	1442	120	18	35575683
Pubmed	PDZ-domain-mediated interaction of the Eph-related receptor tyrosine kinase EphB3 and the ras-binding protein AF6 depends on the kinase activity of the receptor.	NRXN1 NRXN2 AFDN	3.31e-06	9	120	3	9707552
Pubmed	Huntingtin interacting proteins are genetic modifiers of neurodegeneration.	ARHGAP24 FNBP4 SLC1A2 SLC6A1 RACK1 ENO1 ENO3	5.83e-06	197	120	7	17500595
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	ARHGAP24 SPATA20 EDC4 BCR SLC1A2 KIF3A RACK1 NRXN1 LRP1 AFDN PPP1R9B ENO1 GOLGA3 XRCC6	6.26e-06	963	120	14	28671696
Pubmed	BPA modulates the WDR5/TET2 complex to regulate ERβ expression in eutopic endometrium and drives the development of endometriosis.	VAPA RPS5 IDH3A EDC4 ITPR3 ADSL RACK1 TMPO AFDN HEPHL1 ENO1 XRCC6	6.85e-06	711	120	12	33022573
Pubmed	Copy number analysis of complement C4A, C4B and C4A silencing mutation by real-time quantitative polymerase chain reaction.	C4A C4B	1.18e-05	2	120	2	22737222
Pubmed	Deficiency of C4 from donor or recipient mouse fails to prevent renal allograft rejection.	C4A C4B	1.18e-05	2	120	2	16565498
Pubmed	Complete deficiencies of complement C4A and C4B including 2-bp insertion in codon 1213 are genetic risk factors of systemic lupus erythematosus in Thai populations.	C4A C4B	1.18e-05	2	120	2	15998580
Pubmed	High-throughput analysis of the C4 polymorphism by a combination of MLPA and isotype-specific ELISA's.	C4A C4B	1.18e-05	2	120	2	19062096
Pubmed	Activation of innate and humoral immunity in the peripheral nervous system of ALS transgenic mice.	C4A C4B	1.18e-05	2	120	2	19933335
Pubmed	Structural basis for the C4d.1/C4d.2 serologic allotypes of murine complement component C4.	C4A C4B	1.18e-05	2	120	2	2459207
Pubmed	Antigen-induced B cell apoptosis is independent of complement C4.	C4A C4B	1.18e-05	2	120	2	17645767
Pubmed	Distribution of serum neuron-specific enolase and the establishment of a population reference interval in healthy adults.	ENO1 ENO2	1.18e-05	2	120	2	30779465
Pubmed	Anti-DNA autoreactivity in C4-deficient mice.	C4A C4B	1.18e-05	2	120	2	12207352
Pubmed	Complement C4A and C4B Gene Copy Number Study in Alzheimer's Disease Patients.	C4A C4B	1.18e-05	2	120	2	27758680
Pubmed	Genetically determined partial complement C4 deficiency states are not independent risk factors for SLE in UK and Spanish populations.	C4A C4B	1.18e-05	2	120	2	22387014
Pubmed	Complement C4 maintains peripheral B-cell tolerance in a myeloid cell dependent manner.	C4A C4B	1.18e-05	2	120	2	23749435
Pubmed	Copy number variations of complement component C4 are associated with Behçet's disease but not with ankylosing spondylitis associated with acute anterior uveitis.	C4A C4B	1.18e-05	2	120	2	23918728
Pubmed	Differential expression of muscle-specific enolase in embryonic and fetal myogenic cells during mouse development.	ENO1 ENO3	1.18e-05	2	120	2	2090519
Pubmed	Molecular genetics of androgen-dependent and -independent expression of mouse sex-limited protein.	C4A C4B	1.18e-05	2	120	2	3037333
Pubmed	Evidence of a role for C4 in modulating interstitial inflammation in experimental glomerulonephritis.	C4A C4B	1.18e-05	2	120	2	11726230
Pubmed	Quantitative variations in the expression of the mouse serum antigen Ss and its sex-limited allotype Slp.	C4A C4B	1.18e-05	2	120	2	4216347
Pubmed	Mutations in NRXN1 and NRXN2 in a patient with early-onset epileptic encephalopathy and respiratory depression.	NRXN1 NRXN2	1.18e-05	2	120	2	30709877
Pubmed	Sequence determination of the thiolester site of the fourth component of human complement.	C4A C4B	1.18e-05	2	120	2	6950384
Pubmed	Visual demonstration of the organization of the human complement C4 and 21-hydroxylase genes by high-resolution fluorescence in situ hybridization.	C4A C4B	1.18e-05	2	120	2	8660986
Pubmed	Tissue-specific RNA processing for the complement C4 gene transcript in the H-2k mouse strain.	C4A C4B	1.18e-05	2	120	2	8428773
Pubmed	Complement C4 deficiency--a plausible risk factor for non-tuberculous mycobacteria (NTM) infection in apparently immunocompetent patients.	C4A C4B	1.18e-05	2	120	2	24638111
Pubmed	Transcriptional repression of C4 complement by hepatitis C virus proteins.	C4A C4B	1.18e-05	2	120	2	21345967
Pubmed	Restriction fragment analysis of H-2 recombinant mouse strains with crossovers between E alpha and C4 genes.	C4A C4B	1.18e-05	2	120	2	2572548
Pubmed	The complement component C4 of mammals.	C4A C4B	1.18e-05	2	120	2	2302180
Pubmed	Identification of zyklopen, a new member of the vertebrate multicopper ferroxidase family, and characterization in rodents and human cells.	CP HEPHL1	1.18e-05	2	120	2	20685892
Pubmed	Gene CNVs and protein levels of complement C4A and C4B as novel biomarkers for partial disease remissions in new-onset type 1 diabetes patients.	C4A C4B	1.18e-05	2	120	2	22151770
Pubmed	C4d-positive chronic rejection: a frequent entity with a poor outcome.	C4A C4B	1.18e-05	2	120	2	18091514
Pubmed	Comprehensive approach to study complement C4 in systemic lupus erythematosus: Gene polymorphisms, protein levels and functional activity.	C4A C4B	1.18e-05	2	120	2	29080553
Pubmed	Genes for murine fourth complement component (C4) and sex-limited protein (Slp) identified by hybridization to C4- and Slp-specific cDNA.	C4A C4B	1.18e-05	2	120	2	6589636
Pubmed	C4 Deficiency is a predisposing factor for Streptococcus pneumoniae-induced autoantibody production.	C4A C4B	1.18e-05	2	120	2	25339671
Pubmed	A study of association of the complement C4 mutations with systemic lupus erythematosus in the Malaysian population.	C4A C4B	1.18e-05	2	120	2	17728371
Pubmed	Structure and organization of the C4 genes.	C4A C4B	1.18e-05	2	120	2	6149580
Pubmed	Sequence heterogeneity of murine complementary DNA clones related to the C4 and C4-Slp isoforms of the fourth complement component.	C4A C4B	1.18e-05	2	120	2	6149581
Pubmed	The follicular dendritic cell restricted epitope, FDC-M2, is complement C4; localization of immune complexes in mouse tissues.	C4A C4B	1.18e-05	2	120	2	12115608
Pubmed	Biochemistry and biology of anaphylatoxins.	C4A C4B	1.18e-05	2	120	2	3542363
Pubmed	The Placental Ferroxidase Zyklopen Is Not Essential for Iron Transport to the Fetus in Mice.	CP HEPHL1	1.18e-05	2	120	2	34114013
Pubmed	C4 from C4-high and C4-low mouse strains have identical sequences in the region corresponding to the isotype-specific segment of human C4.	C4A C4B	1.18e-05	2	120	2	2387317
Pubmed	HUPO BPP pilot study: a proteomics analysis of the mouse brain of different developmental stages.	ENO1 ENO2	1.18e-05	2	120	2	17922513
Pubmed	Identification of the size and antigenic determinants of the human C4 gene by a polymerase chain-reaction-based amplification method.	C4A C4B	1.18e-05	2	120	2	16908004
Pubmed	Structural studies on the murine fourth component of complement (C4). IV. Demonstration that C4 and Slp are encoded by separate loci.	C4A C4B	1.18e-05	2	120	2	7365238
Pubmed	Interaction between the labile binding sites of the fourth (C4) and fifth (C5) human complement proteins and erythrocyte cell membranes.	C4A C4B	1.18e-05	2	120	2	7391573
Pubmed	Peritubular capillary C4d deposition in lupus nephritis different from antibody-mediated renal rejection.	C4A C4B	1.18e-05	2	120	2	17971360
Pubmed	Clinical features of patients with homozygous complement C4A or C4B deficiency.	C4A C4B	1.18e-05	2	120	2	29928053
Pubmed	Analysis of C4 and the C4 binding protein in the MRL/lpr mouse.	C4A C4B	1.18e-05	2	120	2	17971229
Pubmed	Proteomic Study of Blood Serum in Coronary Atherosclerosis.	CP C4A	1.18e-05	2	120	2	28091899
Pubmed	Genetic deficiency of C4 presenting with recurrent infections and a SLE-like disease. Genetic and immunologic studies.	C4A C4B	1.18e-05	2	120	2	6881182
Pubmed	Partial C4 deficiency in juvenile idiopathic arthritis patients.	C4A C4B	1.18e-05	2	120	2	17921792
Pubmed	Complement activation and complement receptors on follicular dendritic cells are critical for the function of a targeted adjuvant.	C4A C4B	1.18e-05	2	120	2	21880985
Pubmed	Amino acid sequence around the thiol and reactive acyl groups of human complement component C4.	C4A C4B	1.18e-05	2	120	2	6978711
Pubmed	Plasma Complement 3 and Complement 4 Are Promising Biomarkers for Distinguishing NMOSD From MOGAD and Are Associated With the Blood-Brain-Barrier Disruption in NMOSD.	C4A C4B	1.18e-05	2	120	2	35898513
Pubmed	Borrelia burgdorferi outer surface protein C (OspC) binds complement component C4b and confers bloodstream survival.	C4A C4B	1.18e-05	2	120	2	28873507
Pubmed	Heterozygous deletion of α-neurexin I or α-neurexin II results in behaviors relevant to autism and schizophrenia.	NRXN1 NRXN2	1.18e-05	2	120	2	26595880
Pubmed	Studies on the murine Ss protein: demonstration that the Ss protein is functionally the fourth component of complement.	C4A C4B	1.18e-05	2	120	2	276882
Pubmed	Amino acid sequence of a polymorphic segment from fragment C4d of human complement component C4.	C4A C4B	1.18e-05	2	120	2	6832377
Pubmed	Recombination of two homologous MHC class III genes of the mouse (C4 and Slp) that accounts for the loss of testosterone dependence of sex-limited protein expression.	C4A C4B	1.18e-05	2	120	2	3794341
Pubmed	Receptor for activated C-kinase 1, a novel interaction partner of type II bone morphogenetic protein receptor, regulates smooth muscle cell proliferation in pulmonary arterial hypertension.	BMPR2 RACK1	1.18e-05	2	120	2	17515463
Pubmed	Fine-tuned characterization of RCCX copy number variants and their relationship with extended MHC haplotypes.	C4A C4B	1.18e-05	2	120	2	22785613
Pubmed	Association between complement 4 copy number variation and systemic lupus erythematosus: a meta-analysis.	C4A C4B	1.18e-05	2	120	2	32691186
Pubmed	The androgen-dependent C4-Slp gene is driven by a constitutively competent promoter.	C4A C4B	1.18e-05	2	120	2	8390682
Pubmed	Structure and expression of murine fourth complement component (C4) and sex-limited protein (Slp).	C4A C4B	1.18e-05	2	120	2	3902619
Pubmed	Structural polymorphism of murine C4 and its linkage to H-2.	C4A C4B	1.18e-05	2	120	2	7373044
Pubmed	The chemical structure of the C4d fragment of the human complement component C4.	C4A C4B	1.18e-05	2	120	2	3696167
Pubmed	Restriction fragment length polymorphism of the murine C4 and Slp genes: two C4 groups.	C4A C4B	1.18e-05	2	120	2	1357031
Pubmed	Nucleotide sequences of cDNAs alpha and gamma enolase mRNAs from mouse brain.	ENO1 ENO2	1.18e-05	2	120	2	2362815
Pubmed	Structural comparison of human C4A3 and C4B1 after proteolytic activation by C1s.	C4A C4B	1.18e-05	2	120	2	16098595
Pubmed	Peptidylarginine deiminase modulates the physiological roles of enolase via citrullination: links between altered multifunction of enolase and neurodegenerative diseases.	ENO1 ENO2	1.18e-05	2	120	2	22551201
Pubmed	Increased frequency of C4B*Q0 alleles in patients with Henoch-Schönlein purpura.	C4A C4B	1.18e-05	2	120	2	15787745
Pubmed	Neuropil contraction in relation to Complement C4 gene copy numbers in independent cohorts of adolescent-onset and young adult-onset schizophrenia patients-a pilot study.	C4A C4B	1.18e-05	2	120	2	30026462
Pubmed	A molecular map of the human major histocompatibility complex class III region linking complement genes C4, C2 and factor B.	C4A C4B	1.18e-05	2	120	2	6559257
Pubmed	Identification of ATP citrate lyase as a positive regulator of glycolytic function in glioblastomas.	ACLY ENO1	1.18e-05	2	120	2	19795461
Pubmed	Complement C4 Is Reduced in iPSC-Derived Astrocytes of Autism Spectrum Disorder Subjects.	C4A C4B	1.18e-05	2	120	2	34299197
Pubmed	Assessment of complement C4 gene copy number using the paralog ratio test.	C4A C4B	1.18e-05	2	120	2	20506482
Pubmed	Polymerase chain reaction based C4AQ0 and C4BQ0 genotyping: association with systemic lupus erythematosus in southwest Han Chinese.	C4A C4B	1.18e-05	2	120	2	12480675
Pubmed	Complete structure of the human gene encoding neuron-specific enolase.	ENO1 ENO2	1.18e-05	2	120	2	2045099
Pubmed	Low C4, C4A and C4B gene copy numbers are stronger risk factors for juvenile-onset than for adult-onset systemic lupus erythematosus.	C4A C4B	1.18e-05	2	120	2	26800705
Pubmed	Murine complement C4 is not required for experimental autoimmune encephalomyelitis.	C4A C4B	1.18e-05	2	120	2	15390104
Pubmed	Loss of expression of the double strand break repair protein ATM is associated with worse prognosis in colorectal cancer and loss of Ku70 expression is associated with CIN.	ATM XRCC6	1.18e-05	2	120	2	23154512
Pubmed	Importance of the alpha 3-fragment of complement C4 for the binding with C4b-binding protein.	C4A C4B	1.18e-05	2	120	2	1699796
Pubmed	Molecular cloning and characterization of complementary and genomic DNA clones for mouse C4 and Slp.	C4A C4B	1.18e-05	2	120	2	2997024
Pubmed	Constitutive expression of Slp genes in mouse strain B10.WR directed by C4 regulatory sequences.	C4A C4B	1.18e-05	2	120	2	3624865
Pubmed	FBXW10 promotes hepatocarcinogenesis in male patients and mice.	FBXW10B FBXW10	1.18e-05	2	120	2	31400758
Pubmed	Determination of the loss of function complement C4 exon 29 CT insertion using a novel paralog-specific assay in healthy UK and Spanish populations.	C4A C4B	1.18e-05	2	120	2	21857912
Pubmed	Isolation of cDNA clones specifying the fourth component of mouse complement and its isotype, sex-limited protein.	C4A C4B	1.18e-05	2	120	2	6208559
Pubmed	The role of the histocompatibility-2-linked Ss-Slp region in the control of mouse complement.	C4A C4B	1.18e-05	2	120	2	4514997
Pubmed	The inheritance of susceptibility to the Gross leukemia virus in mice.	C4A C4B	1.18e-05	2	120	2	5919331
Interaction	ACO2 interactions	VAPA ARHGAP24 ACADVL RPS5 IDH3A ADSL RACK1 COQ9 TMPO PPP1R9B ENO1 XRCC6	2.29e-07	304	118	12	int:ACO2
Cytoband	2q33-q34	BMPR2 IGFBP2	2.41e-04	9	120	2	2q33-q34
GeneFamily	C3 and PZP like, alpha-2-macroglobulin domain containing	C4A C4B	5.53e-04	9	72	2	1234
GeneFamily	WD repeat domain containing\|F-box and WD repeat domain containing	FBXW10B FBXW10	8.40e-04	11	72	2	559
Coexpression	GSE1925_3H_VS_24H_IFNG_STIM_IFNG_PRIMED_MACROPHAGE_UP	DDX19B EVL SGCB SMYD1 KIF3A NEK1 CELSR1 ENO2	3.80e-06	200	119	8	M6300
Coexpression	JOHNSTONE_PARVB_TARGETS_3_UP	ABCC3 ACADVL ACLY SPATA20 HS1BP3 CELSR1 ERRFI1 LRP1 AFDN ATM ENO2	4.69e-06	433	119	11	M2240
Coexpression	GARY_CD5_TARGETS_UP	WSB1 SAMD1 TCF4 ACLY WNK1 KIF3A GNA13 PPP1R9B ALDH6A1 ENO2 ALOX5	1.08e-05	473	119	11	M17693
ToppCell	human_hepatoblastoma-Tumor_cells-T8\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	ABCC3 CP ONECUT1 SLC1A2 IGFBP2 EXOC3L4 ERRFI1 FYB2	5.31e-08	192	120	8	e785135262f4c9cc66c403bf362bb34643b212c5
ToppCell	3'-Parenchyma_lung-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ABCC3 RPS5 CP IGFBP2 HOXD10 ERRFI1 ENO1 WDR72	6.22e-08	196	120	8	279f43deeba4528cd63f5217a8441b5452bf0b16
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ABCC3 NEBL CREB5 CELSR1 DIP2C AFDN WDR72	9.80e-07	194	120	7	7002937e8903e037332a215d00fbc7c7843b33f2
ToppCell	CV-Moderate\|CV / Virus stimulation, Condition and Cluster	CARMIL3 RPS5 KIF3A RACK1 TMPO AFDN CSGALNACT1	1.09e-06	197	120	7	8747a57ded96175a8365f066101ce2af80c8081d
ToppCell	3'-Parenchyma_lung-Epithelial-Airway_epithelium-respiratory_basal_cell\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ABCC3 RPS5 CP IGFBP2 HOXD10 ERRFI1 ENO1	1.12e-06	198	120	7	eaeb70c0f7f7ca21f7d5bc5ea6c7c1a49a293c45
ToppCell	Control_saline-Epithelial_airway\|Control_saline / Treatment groups by lineage, cell group, cell type	CP SLC1A2 CELSR1 KRT24 CFAP206 HEPHL1 FYB2	1.12e-06	198	120	7	e6863238e022ecfb6a8e3f4b7661b376e92c5d8f
ToppCell	Control_saline-Epithelial_airway-airway_epithelial\|Control_saline / Treatment groups by lineage, cell group, cell type	CP SLC1A2 CELSR1 KRT24 CFAP206 HEPHL1 FYB2	1.12e-06	198	120	7	e7aa42e5fbd42c68f50cda4a8f3aa464c862c007
ToppCell	3'-Parenchyma_lung-Epithelial-Airway_epithelium\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ABCC3 RPS5 CP IGFBP2 HOXD10 ERRFI1 ENO1	1.12e-06	198	120	7	9ec0ed556860e5543d327f4bf2370efc571ad75e
ToppCell	Posterior_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_1-Calb1-Excitatory_Neuron.Sc17a7.Calb1-Ddit4l_(Neurofilament,_Layer4?)\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	SERPINB7 PIWIL2 GARIN4 CFAP206	2.36e-06	35	120	4	afb8cd52dffd630ffe8e7812874d5fd52e0b6752
ToppCell	Control-Epithelial_cells-Airway_basal\|Control / group, cell type (main and fine annotations)	CP SLC6A1 CELSR1 IGFBP2 SULF1 ERRFI1	7.05e-06	171	120	6	3965ced4be6db14265a90673502fceee425837ca
ToppCell	nucseq-Epithelial-Epithelial_Airway-Basal/Suprabasal\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	CP SLC6A1 CELSR1 IGFBP2 SULF1 ERRFI1	8.58e-06	177	120	6	cbad1a23851151dbef01ea2af960e6f0944f838b
ToppCell	nucseq-Epithelial-Epithelial_Airway-Basal/Suprabasal-Basal\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	CP SLC6A1 CELSR1 IGFBP2 SULF1 ERRFI1	8.58e-06	177	120	6	ce86dfaeb74d995a19aea62f0fb15c4c0bb854b0
ToppCell	Children_(3_yrs)-Epithelial-basal_cell\|Children_(3_yrs) / Lineage, Cell type, age group and donor	CP CELSR1 IGFBP2 NRXN1 SULF1 ERRFI1	8.86e-06	178	120	6	fba2e38c05cbf031e0c6d47b1602575fea734a57
ToppCell	COVID-19-kidney-AQP1+SLC14A1+EC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	TCF4 CP BCR SULF1 DOCK6 CSGALNACT1	9.15e-06	179	120	6	1ce8d18f63e8dd2d3db41fbeca4601bd3b305fba
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Myeloid-Dendritic-conventional_dendritic_cell-DC_c2-CD1C\|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)	BCR CREB5 NEK1 PYCARD PPP1R9B ENO3	1.14e-05	186	120	6	b9e0a819cd0b250f077b26eba99e6986d68d647b
ToppCell	Smart-seq2-blood_(Smart-seq2)-myeloid-myeloid_monocytic-classical_monocyte\|blood_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	CREB5 CNTN5 LRP1 ASTN1 PPP1R9B DNAH8	1.14e-05	186	120	6	23b8d51d20b05795a73892d3e20e0f9b6a207820
ToppCell	Control-Lymphoid_B-B_memory\|Control / Disease group, lineage and cell class	TCF4 ARHGAP24 RPS5 BLNK RACK1 DNAH8	1.21e-05	188	120	6	ba4245de3bee29118abab57c4fce60b2007a189c
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	WSB1 NEBL BLNK WNK1 HOXD10 CSGALNACT1	1.21e-05	188	120	6	4154f4787483c7e076e87a187733a9f666742c3d
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	WSB1 NEBL BLNK HOXD10 CSGALNACT1 FYB2	1.25e-05	189	120	6	8ff3c3232eff9de4b5c9b22ecb82bc509d773f58
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	WSB1 NEBL BLNK WNK1 HOXD10 CSGALNACT1	1.25e-05	189	120	6	90aae7e806882bebfad78a78e9a16cf56af3ecd4
ToppCell	pdx-Tumor_cells-T8\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	ABCC3 ONECUT1 SLC1A2 SLC6A1 EXOC3L4 FYB2	1.28e-05	190	120	6	b05db0de9b6ae01dd30074453f7de44f7397631e
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	WSB1 NEBL BLNK HOXD10 CSGALNACT1 FYB2	1.28e-05	190	120	6	4836ea19308d2a96694f12ab0653b7ce7b101d2f
ToppCell	facs-Skin\|facs / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ITPR3 GARIN4 CELSR1 KRT24 PYCARD AFDN	1.32e-05	191	120	6	ae524103331fa53fa82888dbb567fc36abcee7e0
ToppCell	droplet-Limb_Muscle-MUSCLE-30m-Mesenchymal-nan\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARHGAP24 CP CREB5 BMPR2 SULF1 ERRFI1	1.32e-05	191	120	6	7d1595e616f6f111fc2f5bc1b179c5d67d624cc9
ToppCell	343B-Endothelial_cells-Endothelial-B_(Artery)\|343B / Donor, Lineage, Cell class and subclass (all cells)	TCF4 CP OTC BMPR2 SULF1 CSGALNACT1	1.32e-05	191	120	6	27a532a35d9e8822014f581fd56c4ca62e39f8fe
ToppCell	343B-Endothelial_cells-Endothelial-B_(Artery)-\|343B / Donor, Lineage, Cell class and subclass (all cells)	TCF4 CP OTC BMPR2 SULF1 CSGALNACT1	1.32e-05	191	120	6	1dfcff08e01e6a695953334342bcfde04ba005ad
ToppCell	facs-Lung-nan-3m-Mesenchymal\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ASPN CP SULF1 ERRFI1 LRP1 C4B	1.40e-05	193	120	6	d9c20a092b507c43fcf7ccb04073fecd27d1749c
ToppCell	PBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Lymphocytic-Lymphocytic_B-B_cell-B_c02-MS4A1-CD27\|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)	TCF4 ARHGAP24 BLNK CELSR1 CSGALNACT1 ALOX5	1.40e-05	193	120	6	749faa5c592ee354733f5a7363a4277ef3462b93
ToppCell	LPS-IL1RA-Endothelial\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TCF4 BMPR2 IGFBP2 AFDN DOCK6 CSGALNACT1	1.44e-05	194	120	6	43f92b0533e26633dc94cce554045d641ef8fd76
ToppCell	LPS-IL1RA-Endothelial-Endothelial-Gen_Cap\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TCF4 BMPR2 IGFBP2 AFDN DOCK6 CSGALNACT1	1.44e-05	194	120	6	0b9cd96fa0b616da7cc90e92ff71157e9bba518f
ToppCell	LPS-IL1RA-Endothelial-Endothelial\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TCF4 BMPR2 IGFBP2 AFDN DOCK6 CSGALNACT1	1.44e-05	194	120	6	1d39d968730a7e85b6161c1c8a6bd38afe9bcad7
ToppCell	LPS_only-Endothelial\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TCF4 BMPR2 IGFBP2 AFDN DOCK6 CSGALNACT1	1.44e-05	194	120	6	58f069efdefa0366033764446b9d6ffd4a17807e
ToppCell	LPS_only-Endothelial-Endothelial\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TCF4 BMPR2 IGFBP2 AFDN DOCK6 CSGALNACT1	1.44e-05	194	120	6	bfd92ec75facb0ba55c31e5f2e089d983b3d0169
ToppCell	facs-Diaphragm-Limb_Muscle-3m-Mesenchymal\|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VAPA WSB1 TCF4 ARHGAP24 SULF1 ERRFI1	1.49e-05	195	120	6	4d63e0dca30ae57960459d2fbcba09122273e37b
ToppCell	facs-Diaphragm-Limb_Muscle-3m-Mesenchymal-nan\|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VAPA WSB1 TCF4 ARHGAP24 SULF1 ERRFI1	1.49e-05	195	120	6	661af601a3561fe3aacf2444ad7b8927fa88b48a
ToppCell	droplet-Limb_Muscle-MUSCLE-30m-Mesenchymal\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARHGAP24 ASPN CP BMPR2 ERRFI1 LRP1	1.49e-05	195	120	6	5c86fddd6d0530beecf45ea5ba6b823123847696
ToppCell	10x_3'_v2v3-Neoplastic-Differentiated-like-MES-like-MES-like_hypoxia_independent-F\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	WSB1 ABCC3 ACADVL SLC1A2 IGFBP2 SEMA6D	1.53e-05	196	120	6	b8b9801181d7604871b48aebacb295d0a57a5eaf
ToppCell	severe_COVID-19-B_memory\|severe_COVID-19 / disease group, cell group and cell class (v2)	TCF4 ARHGAP24 RPS5 BLNK AFDN DNAH8	1.53e-05	196	120	6	c6e00cb59a88b9903cca233cefe05f80c5ea4153
ToppCell	3'-Parenchyma_lung-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.2.4\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ABCC3 CP IGFBP2 ERRFI1 ENO1 WDR72	1.58e-05	197	120	6	ec7b7cebf60beab1d6dbafb8d6bb832fd8380098
ToppCell	Parenchymal-10x3prime_v2-Epithelial-Epi_airway_ciliated-Deuterosomal\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	FBXW10B FBXW10 CP FAM186B SLC1A2 CFAP206	1.58e-05	197	120	6	861e8df9bd74dc5e17bafdc1fb3fef546753c73a
ToppCell	Brain_organoid-organoid_Paulsen_bioRxiv-3.5_mon-Neuronal-PNs\|3.5_mon / Sample Type, Dataset, Time_group, and Cell type.	WSB1 RPS5 IGFBP2 ENO1 ENO2 GOLGA3	1.62e-05	198	120	6	6408653e956fedb284fa5e69ba8f4d620731f556
ToppCell	Sepsis-ICU-NoSEP-Lymphocyte-B-B_intermediate\|ICU-NoSEP / Disease, condition lineage and cell class	TCF4 ARHGAP24 RPS5 BLNK DNAH8 CSGALNACT1	1.67e-05	199	120	6	97a32b664c89e865cf29f83add794d277fa020cd
ToppCell	Control_saline-Epithelial_airway-airway_epithelial-Airway-Club\|Control_saline / Treatment groups by lineage, cell group, cell type	SERPINB7 CP SLC1A2 CELSR1 KRT24 HEPHL1	1.67e-05	199	120	6	5cc8b553a58669a30eb10845beb23983dcdf5a6a
ToppCell	wk_08-11-Epithelial-Airway_epithelial_progenitor-epi-stalk_intermediate\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	SLC1A2 ITPR3 CELSR1 IGFBP2 ERRFI1 ENO1	1.67e-05	199	120	6	debdd7dba774d9ccff7effc3f4c132393d203dfa
ToppCell	10x_3'_v2v3-Neoplastic-Differentiated-like-MES-like-MES-like_hypoxia/MHC-F\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	WSB1 RPS5 IGFBP2 ERRFI1 ENO1 ENO2	1.67e-05	199	120	6	9838fed26d8572ac29e7b5fd7220180f734d750a
ToppCell	LPS_only-Endothelial-Endothelial-Activated_Gen_Cap\|LPS_only / Treatment groups by lineage, cell group, cell type	TCF4 BCR BMPR2 GNA13 AFDN CSGALNACT1	1.72e-05	200	120	6	6f531a418ff25b59a543800cf4bce7b72404ce08
ToppCell	LPS_only-Endothelial\|LPS_only / Treatment groups by lineage, cell group, cell type	TCF4 BCR BMPR2 AFDN DOCK6 CSGALNACT1	1.72e-05	200	120	6	81e76508c9050d533853d5fd2f3097b27613d836
ToppCell	Control_saline-Endothelial-Endothelial\|Control_saline / Treatment groups by lineage, cell group, cell type	TCF4 BMPR2 AFDN PPP1R9B DOCK6 CSGALNACT1	1.72e-05	200	120	6	e77eba6172cabf85b8028638ed35299f2f079cd8
ToppCell	MS-Multiple_Sclerosis-Lymphocyte-B\|Multiple_Sclerosis / Disease, condition lineage and cell class	TCF4 ARHGAP24 RPS5 BLNK DOCK6 ALOX5	1.72e-05	200	120	6	082b3be49fa9d65ed8351d4e80680583f8735207
ToppCell	LPS_IL1RA_TNF-Endothelial-Endothelial\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	TCF4 BMPR2 AFDN PPP1R9B DOCK6 CSGALNACT1	1.72e-05	200	120	6	a1fa6bae5a688faf488d6925cd3fad725dfa916b
ToppCell	LPS_anti-TNF-Endothelial-Endothelial-Alv_Gen_Intermediate\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	TCF4 BMPR2 AFDN PPP1R9B DOCK6 CSGALNACT1	1.72e-05	200	120	6	89a6da2bdedc6b1ad0675c8753bf2b763a99af6a
ToppCell	LPS_anti-TNF-Endothelial\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	TCF4 BMPR2 AFDN PPP1R9B DOCK6 CSGALNACT1	1.72e-05	200	120	6	1d105eeda5a2c51f9a4654ffc79b7e2348ad593b
ToppCell	LPS_IL1RA_TNF-Endothelial-Endothelial-Alv_Gen_Intermediate\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	TCF4 BMPR2 AFDN PPP1R9B DOCK6 CSGALNACT1	1.72e-05	200	120	6	58a7ece7dfdf6c46f2a50cbcb580574dec14c748
ToppCell	LPS_IL1RA_TNF-Endothelial\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	TCF4 BMPR2 AFDN PPP1R9B DOCK6 CSGALNACT1	1.72e-05	200	120	6	d01cec331be3b03cef80e9536fc531285bcf00f6
ToppCell	LPS_anti-TNF-Endothelial-Endothelial\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	TCF4 BMPR2 AFDN PPP1R9B DOCK6 CSGALNACT1	1.72e-05	200	120	6	60d2cbf41f37f1b11eddb4c9d9246c9c1fc5a5af
ToppCell	Control_saline-Endothelial\|Control_saline / Treatment groups by lineage, cell group, cell type	TCF4 BMPR2 AFDN PPP1R9B DOCK6 CSGALNACT1	1.72e-05	200	120	6	3372c488a39fe812fa94e4f0564594186fea3db5
ToppCell	LPS_only-Endothelial-Endothelial\|LPS_only / Treatment groups by lineage, cell group, cell type	TCF4 BCR BMPR2 AFDN DOCK6 CSGALNACT1	1.72e-05	200	120	6	4bb609a284d4e6066f17470a1736076aa4a1f84c
ToppCell	PBMC-Control-Lymphocyte-B-B_cell-B_memory-B_memory-6\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	TCF4 BLNK NRXN1 DNAH8 WDR72	5.22e-05	149	120	5	2cd860b96ed4be4d26844085d464961c1418054a
ToppCell	LPS-antiTNF-Epithelial_alveolar-AT_1-AT1_Progenitor\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CYP11A1 RPS5 RACK1 ERRFI1 ENO1	5.74e-05	152	120	5	960fa1af2a1499796ac79ccbd884fe2ca14c0ca8
ToppCell	droplet-Liver-Hepatocytes-18m-Myeloid-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TMEM170B SLC1A2 NCAPG2 NRXN1 PYCARD	6.50e-05	156	120	5	d72c2f5f72d269e29033f8728d924e0d4c8772c7
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_B-B_cell-B_c03-CD27-AIM2\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	TCF4 ARHGAP24 BLNK CELSR1 EXOC3L4	6.50e-05	156	120	5	4e4b94580969a9736ca28df79715535a4bd1f9b2
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Principal_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	BLNK WNK1 CSGALNACT1 FYB2 WDR72	7.77e-05	162	120	5	285e6d553f485fd9f1075c4e1b940da251b5ea35
ToppCell	E16.5-samps-Mesenchymal-Matrix_fibroblast-_fetal-Mature_Fibroblast_1\|E16.5-samps / Age Group, Lineage, Cell class and subclass	NEBL CYP11A1 CP EXOC3L4 LRP1	7.99e-05	163	120	5	f1ec2625b52664308968b01d8e0275e1e0751480
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	BLNK WNK1 CSGALNACT1 FYB2 WDR72	8.23e-05	164	120	5	6fb2136168f430babfeb81ca7e151ca7a8092ec4
ToppCell	PND03-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TCF4 BCR NRXN2 HOXD10 ASTN1	8.47e-05	165	120	5	347b59aa625a8a960828b8620824d8ac48990e07
ToppCell	PND03-Endothelial-Endothelial_lymphatic-Lymphatic_EC\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TCF4 BCR NRXN2 HOXD10 ASTN1	8.47e-05	165	120	5	507c89ece0a336b8e9c65b79889a714e17ddca27
ToppCell	PND03-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_mature\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TCF4 BCR NRXN2 HOXD10 ASTN1	8.47e-05	165	120	5	39a25be081a5d59c7cf107a997d352793d5025fb
ToppCell	PND03-Endothelial-Endothelial_lymphatic\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TCF4 BCR NRXN2 HOXD10 ASTN1	8.47e-05	165	120	5	1890f9c33b0c5b381d57f97042da2610a093a6de
ToppCell	droplet-Liver-LIVER_HEPATOCYTES-30m-Myeloid-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NEBL PIWIL2 CREB5 LRRC9 CCDC158	8.96e-05	167	120	5	cf6206c506715cd846799c62cf7c06e3fa99f7af
ToppCell	3'_v3-GI_small-bowel-Lymphocytic_B-Memory_B_cells\|GI_small-bowel / Manually curated celltypes from each tissue	TCF4 ARHGAP24 BLNK CELSR1 CSGALNACT1	9.22e-05	168	120	5	8e025bb0541746e232b77ac0e31412ae71420c47
ToppCell	droplet-Lung-LUNG-30m-Myeloid-plasmacytoid_dendritic_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TCF4 BLNK BCR NRXN2 FYB2	9.22e-05	168	120	5	e156297a7515e785a9e79a9676700bd3a9d92b98
ToppCell	Control-Epithelial_airway-Club_cells-Airway\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CP SLC1A2 CELSR1 KRT24 OTOP1	9.22e-05	168	120	5	ce87981f4da2779de952c2e5d2bbcdabb265e705
ToppCell	COVID-19-Heart-Neuronal\|COVID-19 / Disease (COVID-19 only), tissue and cell type	ARHGAP24 SEMA6D NRXN1 DIP2C ALK	9.22e-05	168	120	5	88c2c574f428c2502b5fe099bd73b0758f668ef6
ToppCell	droplet-Lung-LUNG-30m-Myeloid-Plasmacytoid_Dendritic\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TCF4 BLNK BCR NRXN2 FYB2	9.22e-05	168	120	5	32e0bc0873baa13027241063283ef26d2aab56f5
ToppCell	Control-Epithelial_airway-Club_cells\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CP SLC1A2 CELSR1 KRT24 OTOP1	9.22e-05	168	120	5	e85bc5398eb36b2b0773a8a7082e3ba740452165
ToppCell	URO-Lymphocyte-B-B_intermediate\|URO / Disease, Lineage and Cell Type	TCF4 ARHGAP24 BLNK CELSR1 CSGALNACT1	9.74e-05	170	120	5	e11d1510518cedabeece96d4adbb90999e6326fa
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Vip\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	WSB1 TCF4 ARHGAP24 CP SLC6A1	1.00e-04	171	120	5	5efd15300f865ebf651e0888265cbd717bc3b9d3
ToppCell	Int-URO-Lymphocyte-B-B_memory\|Int-URO / Disease, Lineage and Cell Type	TCF4 ARHGAP24 RPS5 FAM186B DNAH8	1.03e-04	172	120	5	38ebfb060c1c9ce9dea6b5833051c5bccb687e29
ToppCell	droplet-Marrow-BM_(NON-STC)-30m-Lymphocytic-plasma_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CP ONECUT1 SLC6A1 SEMA6D C4B	1.03e-04	172	120	5	7295bf3ae21a61dd6bcfa0dfb7a37d0f3e8f94ab
ToppCell	facs-Large_Intestine-Distal-18m-Epithelial-epithelial_cell_of_large_intestine\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ASPN RPS5 NCAPG2 GARIN4 DNAH8	1.06e-04	173	120	5	a5172dee859bf6c2eed46c48bd64dfef0ff9f28f
ToppCell	facs-Large_Intestine-Distal-18m-Epithelial-Lgr5-_amplifying_undifferentiated_cell\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ASPN RPS5 NCAPG2 GARIN4 DNAH8	1.06e-04	173	120	5	639b5b0b33ce5aa0bc26363c059717012ddc14c0
ToppCell	droplet-Lung-30m-Hematologic-myeloid-plasmacytoid_dendritic_cell\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	TCF4 BLNK BCR NRXN2 FYB2	1.06e-04	173	120	5	4f0c065e876197ad8cae7856669f09e37ecafa3f
ToppCell	droplet-Lung-30m-Hematologic-myeloid-plasmacytoid_dendritic_cell-plasmacytoid_dendritic\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	TCF4 BLNK BCR NRXN2 FYB2	1.06e-04	173	120	5	9bbea566964281f47bf75d665b7d69ba8326e207
ToppCell	facs-Brain_Non-Myeloid-Cortex_-18m-Myeloid-microglial_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABCC3 ARL11 BLNK PIWIL2 OTOP1	1.09e-04	174	120	5	8d6df5938cef542f23259ce471eea1a1afbed03c
ToppCell	facs-Brain_Non-Myeloid-Cortex_-18m-Myeloid\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABCC3 ARL11 BLNK PIWIL2 OTOP1	1.09e-04	174	120	5	2af54c3427aacfa232e2aca6003b4a8ecb8bba66
ToppCell	facs-Brain_Non-Myeloid-Cortex_-18m-Myeloid-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABCC3 ARL11 BLNK PIWIL2 OTOP1	1.09e-04	174	120	5	eca643b8f5b92aeed5a77c94b4301fd8100f9401
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW10-Neuronal-GABAergic_neurons\|GW10 / Sample Type, Dataset, Time_group, and Cell type.	MYOZ2 SLC6A1 CFAP206 ALK GOLGA3	1.12e-04	175	120	5	d4ff1f197ad4086286e86817cbff24fa718293fc
ToppCell	PBMC-Convalescent-Lymphocyte-B-B_cell-B_intermediate-B_intermediate-14\|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	ARHGAP24 ARL11 BLNK AFDN ALOX5	1.12e-04	175	120	5	87e557f7508c88b2087db5d57e77d5e2c92ca083
ToppCell	droplet-Marrow-nan-3m-Lymphocytic-NK_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	WSB1 IL12RB2 LRP1 ENO1 ENO3	1.12e-04	175	120	5	cf53a15bfb37b6019e7052ffdf594a9ac040900e
ToppCell	(1)_B_cell-(100)_CD19+_Naive_B_cell\|(1)_B_cell / immune cells in Peripheral Blood (logTPM normalization)	EVL ARHGAP24 RPS5 RACK1 ALOX5	1.15e-04	176	120	5	08bf8485422fce1a4a3b1e7f6b9fab735ce61d46
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_IT_L5/L6_Car3_THEMIS-Exc_L5-6_THEMIS_GPR21\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ABCC3 SMYD1 CREB5 SEMA6D CSGALNACT1	1.15e-04	176	120	5	03d194c9814e12802cd932afade69e868814cb78
ToppCell	(1)_B_cell-(10)_B_cell-(100)_CD19+_Naive_B_cell\|(10)_B_cell / immune cells in Peripheral Blood (logTPM normalization)	EVL ARHGAP24 RPS5 RACK1 ALOX5	1.15e-04	176	120	5	184f46f01d30630e4bc14eaefb3de9e2a147ccd4
ToppCell	PND14-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_T-CD4_T\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	EVL RPS5 RACK1 PYCARD ENO1	1.18e-04	177	120	5	0d6167c6a11c7dec0717ae7c8b4c45341585804f
ToppCell	COVID-19_Moderate-B_intermediate\|COVID-19_Moderate / disease group, cell group and cell class	TCF4 ARHGAP24 BLNK CFAP206 DNAH8	1.18e-04	177	120	5	68e3d12a0c048a2d0f1b9680c7338a35855bba30
ToppCell	droplet-Limb_Muscle-nan-18m-Mesenchymal-skeletal_muscle_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SMYD1 MYOZ2 IDH3A COQ9 ENO3	1.18e-04	177	120	5	f6ff1b035fa2418f2448c99d81faa927ece93dfa
ToppCell	TCGA-Brain-Primary_Tumor-Low_Grade_Glioma\|TCGA-Brain / Sample_Type by Project: Shred V9	ANKRD26 BCR KIF3A DIP2C RBM17	1.18e-04	177	120	5	e8ab340b20cd41554c3841fe980e078e878af35f
ToppCell	PBMC-Convalescent-Lymphocyte-B-B_cell-B_intermediate-B_intermediate-0\|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	TCF4 ARHGAP24 BLNK CSGALNACT1 ALOX5	1.21e-04	178	120	5	be1d991c5a0a5be22f14f57d34ee1330f1a12963
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_IT_L5/L6_Car3_THEMIS\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ABCC3 SMYD1 CREB5 SEMA6D CSGALNACT1	1.21e-04	178	120	5	a62137d7f5fac16619f8a02844cdb0be7a794bf2
ToppCell	COVID-19_Moderate-B_intermediate\|World / disease group, cell group and cell class	TCF4 ARHGAP24 BLNK CFAP206 DNAH8	1.27e-04	180	120	5	bd81b87a6dc81e5ab4a6c948eb0c80f14401a6a7
ToppCell	droplet-Heart-nan-24m-Mesenchymal-smooth_muscle_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IL12RB2 ASPN NRXN1 ERRFI1 ASTN1	1.27e-04	180	120	5	78fdcfb3fdbf36469cae78407cda5bd0996930d8
Drug	dimidium	CP ENO1 ENO2 ENO3	1.06e-08	6	119	4	CID000068207
Drug	N-tert-butylacrylamide	ADSL ENO1 ENO2 ENO3	2.45e-08	7	119	4	CID000007877
Drug	N-succinylphenylglycine	ENO1 ENO2 ENO3	1.39e-07	3	119	3	CID000448582
Drug	AC1MOUJL	ENO1 ENO2 ENO3	1.39e-07	3	119	3	CID003400924
Drug	C03356	ENO1 ENO2 ENO3	1.39e-07	3	119	3	CID000439988
Drug	3-bromo-2-(bromomethyl)propionic acid	ENO1 ENO2 ENO3	1.39e-07	3	119	3	CID000318915
Drug	C04309	ENO1 ENO2 ENO3	1.39e-07	3	119	3	CID000440293
Drug	2,3-diketo-1-phosphohexane	ENO1 ENO2 ENO3	1.39e-07	3	119	3	CID000192519
Drug	dimethyl chlorophosphate	ENO1 ENO2 ENO3	5.55e-07	4	119	3	CID000101863
Drug	[2-(oxidoamino)-2-oxoethyl]phosphonic acid	ENO1 ENO2 ENO3	5.55e-07	4	119	3	CID011969443
Drug	3-aminoenolpyruvate-2-phosphate	ENO1 ENO2 ENO3	5.55e-07	4	119	3	CID003037152
Drug	2-ptz	ENO1 ENO2 ENO3	5.55e-07	4	119	3	CID000445375
Drug	tricyclohexylammonium	ENO1 ENO2 ENO3	5.55e-07	4	119	3	CID000226271
Drug	N-methylacrylamide	ENO1 ENO2 ENO3	1.38e-06	5	119	3	CID000014471
Drug	AC1L1CAI	ENO1 ENO2 ENO3	1.38e-06	5	119	3	CID000000145
Drug	tartronate semialdehyde phosphate	ENO1 ENO2 ENO3	1.38e-06	5	119	3	CID000151938
Drug	2-phospho-3-butenoic acid	ENO1 ENO2 ENO3	1.38e-06	5	119	3	CID000191423
Drug	1-Pdmsp	ENO1 ENO2 ENO3	1.38e-06	5	119	3	CID000000561
Drug	AC1L1A7Z	IDH3A ENO1 ENO2 ENO3	2.05e-06	18	119	4	CID000000874
Drug	Z(2-Cl)-OSu	ENO1 ENO2 ENO3	2.75e-06	6	119	3	CID000580665
Drug	4-(N,N-dimethylamino)cinnamoyl-CoA	ENO1 ENO2 ENO3	2.75e-06	6	119	3	CID000445461
Drug	glycidol phosphate	ENO1 ENO2 ENO3	4.80e-06	7	119	3	CID000152659
Drug	lavendustin C6	ENO1 ENO2 ENO3	4.80e-06	7	119	3	CID000126839
Drug	CPEP	ENO1 ENO2 ENO3	4.80e-06	7	119	3	CID000360637
Drug	OF L	IL12RB2 SLC6A1 ENO1 ENO2 ENO3	5.69e-06	49	119	5	CID000445155
Drug	Aspidium	VAPA ACLY IDH3A BCR OTC GK2 ENO1 ENO2	5.71e-06	184	119	8	CID000000815
Drug	Dicumarol [66-76-2]; Down 200; 11.8uM; PC3; HT_HG-U133A	WSB1 SGCB WNK1 CREB5 GNA13 RBM5 TMPO ATM	6.43e-06	187	119	8	4323_DN
Drug	macrophomate	ENO1 ENO2 ENO3	7.65e-06	8	119	3	CID010889109
Drug	phosphoglycolate	BLNK ITPR3 ENO1 ENO2 ENO3 XRCC6	7.82e-06	90	119	6	CID000000529
Drug	Benzydamine hydrochloride [132-69-4]; Down 200; 11.6uM; PC3; HT_HG-U133A	TCF4 BCR KIF3A BMPR2 RBM5 TMPO ATM ALDH6A1	9.41e-06	197	119	8	5811_DN
Drug	AC1L19IJ	ENO1 ENO2 ENO3	1.14e-05	9	119	3	CID000000562
Drug	AC1L1A4W	ENO1 ENO2 ENO3	1.14e-05	9	119	3	CID000000837
Drug	tetrahydroaldosterone-3-glucuronide	LRP1 ENO1 ENO2 ENO3	1.52e-05	29	119	4	CID000167918
Drug	pyrene-4,5-dione	ENO1 ENO2 ENO3	1.63e-05	10	119	3	CID000160814
Drug	L-fuconic acid	ENO1 ENO2 ENO3	1.63e-05	10	119	3	CID000345732
Drug	phosphoenolthiopyruvate	ENO1 ENO2 ENO3	1.63e-05	10	119	3	CID000194910
Drug	xylonate	ENO1 ENO2 ENO3	1.63e-05	10	119	3	CID000010264
Drug	octanoylcarnitine	ACADVL OTC C4A ATM	1.75e-05	30	119	4	CID000123701
Drug	QS-21	EVL BCR OTC ENO1 ENO2 ENO3	1.80e-05	104	119	6	CID000060866
Drug	LG61	ENO1 ENO2 ENO3	2.96e-05	12	119	3	CID000520177
Drug	AC1L18ZV	ENO1 ENO2 ENO3	2.96e-05	12	119	3	CID000000329
Drug	B-43	ENO1 ENO2 ENO3	4.86e-05	14	119	3	CID006603792
Drug	Hecameg	ENO1 ENO2 ENO3	4.86e-05	14	119	3	CID002733955
Drug	pipemidic acid	ENO1 ENO2 ENO3	6.05e-05	15	119	3	CID000004831
Drug	1 IN	ENO1 ENO2 ENO3	6.05e-05	15	119	3	CID000449311
Drug	Cloperastine hydrochloride [14984-68-0]; Down 200; 11uM; PC3; HT_HG-U133A	TCF4 ARHGAP24 SGCB WNK1 SPIN1 RBM5 TMPO	6.22e-05	189	119	7	4271_DN
Drug	Beclomethasone dipropionate [5534-09-8]; Up 200; 7.6uM; PC3; HT_HG-U133A	WSB1 MYOZ2 CREB5 ITPR3 GK2 SULF1 AFDN	6.65e-05	191	119	7	4580_UP
Drug	Pempidine tartrate [546-48-5]; Down 200; 13uM; MCF7; HT_HG-U133A	WSB1 ABCC3 SGCB WNK1 SPIN1 RBM5 TMPO	6.65e-05	191	119	7	3926_DN
Drug	Freon 22	ENO1 ENO2 ENO3	7.42e-05	16	119	3	CID000006372
Drug	succinate	SGCB CYP11A1 IDH3A OTC ADSL NRXN2 ENO1 ENO2 ENO3	7.44e-05	339	119	9	CID000001110
Drug	Atractyloside potassium salt [102130-43-8]; Down 200; 5uM; PC3; HT_HG-U133A	NEBL BCR CREB5 DOCK6 ALDH6A1 ALK BMP15	7.57e-05	195	119	7	3695_DN
Drug	(-)-Adenosine 3',5'-cyclic monophosphate [60-92-4]; Up 200; 12.2uM; HL60; HT_HG-U133A	TCF4 ASPN BCR SEMA6D TMPO AFDN DOCK6	7.82e-05	196	119	7	2969_UP
Drug	STOCK1N-35874; Down 200; 14uM; PC3; HT_HG-U133A	ABCC3 SGCB ANKRD26 HS1BP3 WNK1 ENO1 ALDH6A1	8.07e-05	197	119	7	6561_DN
Drug	Mepenzolate bromide [76-90-4]; Down 200; 9.6uM; PC3; HT_HG-U133A	ACLY WNK1 NEK1 BMPR2 RBM5 TMPO DOCK6	8.07e-05	197	119	7	3748_DN
Drug	2-aminothiophenol	C4A C4B	8.10e-05	3	119	2	ctd:C005464
Drug	Butylparaben [94-26-8]; Down 200; 20.6uM; MCF7; HT_HG-U133A	ANKRD26 IDH3A NEK1 GNA13 RBM5 ATM ENO1	8.33e-05	198	119	7	6446_DN
Drug	Doxylamine succinate [562-10-7]; Down 200; 10.2uM; PC3; HG-U133A	ABCC3 EVL CEP85 ACLY ITPR3 DOCK6 ENO1	8.33e-05	198	119	7	1893_DN
Drug	Dioxybenzone [131-53-3]; Up 200; 16.4uM; HL60; HT_HG-U133A	NEBL KIF3A NRXN1 DOCK6 ALK ALOX5 BMP15	8.60e-05	199	119	7	3101_UP
Drug	2-PE	ENO1 ENO2 ENO3	8.97e-05	17	119	3	CID000004867
Drug	beta-hydroxyaspartic acid	SLC1A2 ADSL PYCARD C4A	1.06e-04	47	119	4	CID000005425
Drug	hydroxyl radical	RPS5 CP GK2 SPIN1 RBM5 TMPO ALOX5	1.07e-04	206	119	7	CID000157350
Drug	N,N-Dichlorourethane	ENO1 ENO2 ENO3	1.07e-04	18	119	3	CID000026195
Drug	o-succinylbenzoic acid	ENO1 ENO2 ENO3	1.07e-04	18	119	3	CID000000955
Drug	purpurin-18	ENO1 ENO2 ENO3	1.27e-04	19	119	3	CID005489047
Drug	AC1L2YVP	ENO1 ENO2 ENO3	1.27e-04	19	119	3	CID000080135
Drug	histidinol phosphate	ENO1 ENO2 ENO3	1.27e-04	19	119	3	CID000000845
Drug	Chlorpyrifos	ABCC3 TCF4 CYP11A1 FNBP4 SPATA20 EDC4 BCR SLC1A2 SULF1 GNA13 PYCARD ERRFI1 RBM5 ATM ALK	1.46e-04	960	119	15	ctd:D004390
Drug	enoxacin	ENO1 ENO2 ENO3	1.49e-04	20	119	3	CID000003229
Drug	2-iodo-7,8-dibromodibenzo-p-dioxin	ADSL ATM	1.61e-04	4	119	2	CID000159485
Drug	borate	WNK1 ITPR3 OTC ADSL C4A	1.65e-04	98	119	5	CID000007628
Drug	beta-ketoadipate	ADSL ENO1 ENO2 ENO3	1.70e-04	53	119	4	CID000000093
Drug	glycerol-3-phosphate	ACLY IDH3A SLC6A1 GK2 ENO1 ENO2 ENO3	1.89e-04	226	119	7	CID000000754
Drug	Acth(11-24)	ENO1 ENO2 ENO3	1.99e-04	22	119	3	CID003037130
Drug	allulose 6-phosphate	ACADVL ACLY GK2 ENO1 ENO2 ENO3	2.12e-04	162	119	6	CID000000603
Drug	hydroxymalonate	ENO1 ENO2 ENO3	2.28e-04	23	119	3	CID000000044
Disease	Adenocarcinoma of lung (disorder)	WNK1 NEK1 ATM ENO1 ALK ALOX5 XRCC6	1.51e-05	206	113	7	C0152013
Disease	PITT-HOPKINS SYNDROME	TCF4 NRXN1	4.35e-05	3	113	2	C1970431
Disease	Rheumatoid Arthritis	ABCC3 CP HOXD10 TMPO ENO1 ALOX5	5.78e-05	174	113	6	C0003873
Disease	chronotype measurement	TMEM170B TCF4 ARHGAP24 FNBP4 SEMA6D NRXN1 PRPF3 SULF1 CNTN5 RBM5 DIP2C WDR72	1.47e-04	882	113	12	EFO_0008328
Disease	Amyotrophic Lateral Sclerosis With Dementia	SLC1A2 SLC6A1 NEK1	1.86e-04	29	113	3	C0393554
Disease	Liver Cirrhosis, Experimental	TCF4 SGCB ASPN ARL11 BCR RIT1 OTC IGFBP2 SEMA6D PYCARD CSGALNACT1	1.94e-04	774	113	11	C0023893
Disease	Amyotrophic Lateral Sclerosis, Guam Form	SLC1A2 SLC6A1 NEK1	2.27e-04	31	113	3	C0543859
Disease	Endotoxemia	OTC ALOX5	4.01e-04	8	113	2	C0376618
Disease	beta-defensin 119 measurement	WNK1 C4B	4.01e-04	8	113	2	EFO_0801419
Disease	Bipolar Disorder	VAPA TCF4 BCR SLC1A2 IGFBP2 RACK1 NRXN1 DNAH8	5.12e-04	477	113	8	C0005586
Disease	Schizophrenia	TCF4 CP SLC1A2 SLC6A1 NRXN1 NRXN2 LRP1 PPP1R9B ATM ENO2 ALK	5.88e-04	883	113	11	C0036341
Disease	Small Lymphocytic Lymphoma	ARL11 ATM	6.41e-04	10	113	2	C0855095
Disease	B-CELL MALIGNANCY, LOW-GRADE	ARL11 ATM	6.41e-04	10	113	2	C1868683
Disease	urate measurement	DDX19B TCF4 NEBL INTS7 ASPN BMPR2 NSUN3 NRXN1 NRXN2 SPIN1 LRP1	6.57e-04	895	113	11	EFO_0004531
Disease	Paranoia	TCF4 DNAH8	7.82e-04	11	113	2	C1456784
Disease	argininosuccinate measurement	ADSL ALK	7.82e-04	11	113	2	EFO_0010461
Disease	response to radiation, breast carcinoma	NEBL SEMA6D	7.82e-04	11	113	2	EFO_0000305, GO_0009314
Disease	Cardiomyopathy, Dilated	SGCB TMPO ATM	8.34e-04	48	113	3	C0007193
Disease	attention deficit hyperactivity disorder, substance abuse, antisocial behaviour measurement	TCF4 BLNK BTAF1 FAM186B BMPR2 NSUN3 SEMA6D NRXN1 NRXN2 GOLGA3	1.03e-03	801	113	10	EFO_0003888, EFO_0007052, MONDO_0002491
Disease	Hereditary Motor and Sensory-Neuropathy Type II	WNK1 HOXD10	1.10e-03	13	113	2	C0270914
Disease	Mouth Neoplasms	RACK1 HOXD10 ENO1	1.18e-03	54	113	3	C0026640
Disease	Malignant neoplasm of mouth	RACK1 HOXD10 ENO1	1.18e-03	54	113	3	C0153381
Disease	Squamous cell carcinoma	RACK1 PYCARD ATM ENO1	1.34e-03	124	113	4	C0007137
Disease	loneliness measurement	TCF4 FNBP4 SLC6A1 CNTN5	1.34e-03	124	113	4	EFO_0007865
Disease	Amyotrophic Lateral Sclerosis	SLC1A2 SLC6A1 NEK1	1.45e-03	58	113	3	C0002736
Disease	cigarettes per day measurement	TCF4 BTAF1 WNK1 CREB5 ZNF19 NSUN3 SEMA6D	1.52e-03	438	113	7	EFO_0006525
Disease	Cardiomyopathies	NEBL SGCB MYOZ2 RIT1	1.60e-03	130	113	4	C0878544
Disease	smoking status measurement	FOCAD GK2 NSUN3 SEMA6D NRXN1 NRXN2 PTCD1 CNTN5 DNAH8 ALK GOLGA3 WDR72	1.65e-03	1160	113	12	EFO_0006527
Disease	gout, hyperuricemia	NSUN3 CNTN5	1.68e-03	16	113	2	EFO_0004274, EFO_0009104
Disease	attention deficit hyperactivity disorder, schizophrenia	TCF4 CREB5 SEMA6D	1.92e-03	64	113	3	EFO_0003888, MONDO_0005090
Disease	breast carcinoma (is_marker_for)	AFDN ATM ENO2	2.10e-03	66	113	3	DOID:3459 (is_marker_for)
Disease	schizophrenia (implicated_via_orthology)	SLC6A1 NRXN1 ASTN1	2.29e-03	68	113	3	DOID:5419 (implicated_via_orthology)
Disease	grip strength measurement	TCF4 FNBP4 CREB5 CELSR1 NSUN3 SEMA6D	2.33e-03	350	113	6	EFO_0006941
Disease	uric acid measurement	TCF4 INTS7 BMPR2 NSUN3 NRXN2 SPIN1 DIP2C WDR72	2.44e-03	610	113	8	EFO_0004761
Disease	Non-Small Cell Lung Carcinoma	PYCARD ENO1 ENO2 ALK	3.10e-03	156	113	4	C0007131
Disease	Autistic Disorder	CP ADSL NRXN1 NRXN2 C4B	3.37e-03	261	113	5	C0004352
Disease	Morbilliform Drug Reaction	C4B ALOX5	3.49e-03	23	113	2	C0406537
Disease	Immunologic Deficiency Syndromes	C4A ATM	3.49e-03	23	113	2	C0021051
Disease	Drug Eruptions	C4B ALOX5	3.49e-03	23	113	2	C0011609
Disease	Alcoholic Intoxication, Chronic	SLC1A2 SLC6A1 RACK1 ASTN1 ALK	3.77e-03	268	113	5	C0001973
Disease	Albuminuria	CP PYCARD	3.80e-03	24	113	2	C0001925

Protein segments in the cluster

Peptide	Gene	Start	Entry
MASASGAMAKHEQIL	VAPA	1	Q9P0L0
TMLQSGMKVQFGASH	AFDN	481	P55196
MGLQEMAGQLQAATH	PYCARD	76	Q9ULZ3
ERMHGSQKMSLDAQA	EXOC3L4	596	Q17RC7
SKAMNEASHGQLGML	CSGALNACT1	496	Q8TDX6
GVAHNNLMAMAQETG	C4B	1211	P0C0L5
QAMQMERKKSQHGAG	BCR	206	P11274
MAQQVKMDLSAHGFI	FBXW10	311	Q5XX13
MRNLSVDGKNVDMAG	CELSR1	1621	Q9NYQ6
MAMIRDSGAIAAGHQ	FAM186B	376	Q8IYM0
VHKNNRSDMMSALGL	ANKRD26	396	Q9UPS8
GSHAGNKLAMQEFMI	ENO2	156	P09104
FKGMNALHVLEMSAN	ASPN	191	Q9BXN1
SDSGTKHMAAGVRME	ASTN1	926	O14525
GAQEVEMMTKQLGAH	CFAP206	286	Q8IYR0
GVLMIHNVNQSDAGM	CNTN5	441	O94779
NLDMAHRAKVAMSGR	RBM15B	386	Q8NDT2
NNMVMHFAAVLLDGG	OR7A2P	196	Q8NGA2
MTEQMTLRGTLKGHN	RACK1	1	P63244
DHMGSVMAQVRQKLF	EDC4	1356	Q6P2E9
RQASRMGNHDMAKEL	INTS7	531	Q9NVH2
KNVRRSIQGVGHMMS	ITPR3	911	Q14573
MAMAAGGIQAARVLH	ABCC3	1031	O15438
DMIAERQGHSNFKQM	LRRC9	1081	Q6ZRR7
SRGHKAEAQVVMMGL	ARL11	6	Q969Q4
MAQQVKMDLSAHGFI	FBXW10B	311	O95170
NKMHAINGRMFGNLQ	CP	956	P00450
KRNISMHNAVGGAMT	CREB5	96	Q02930
QANMGAKNHGVVMPD	ALDH6A1	281	Q02252
NSHGNIMPMDIKGIA	NSUN3	281	Q9H649
VKMAAHTMGNATVGR	TMPO	636	P42166
KREAMQNKARAEGHM	NEK1	541	Q96PY6
HLQVDGGMTSNKILM	GK3P	421	Q14409
HGRDVNVMAKMAERS	GARIN4	546	Q8IYT1
AKGFQHQRMTNGAMN	LRP1	4451	Q07954
MHHQQRMAALGTDKE	TCF4	1	P15884
KGIQGHQASEKDMMH	IL12RB2	731	Q99665
VLFMEHRAQMAEGGQ	BMP15	16	O95972
MRVAEGHNKMLSNVA	CARMIL3	786	Q8ND23
GGLVENHVDSTMNML	IGFBP2	156	P18065
MANITRMANHTGKLD	OR2T5	1	Q6IEZ7
DGNNILHSIMMSAAK	OTC	196	P00480
HSRMKPAGSVNDMAL	EVL	361	Q9UI08
VHARKLIQMSMQQGG	DNAH8	3946	Q96JB1
SQQIRKMEHAGAMAG	GPR119	196	Q8TDV5
MNAQLTMEAIGELHG	ONECUT1	1	Q9UBC0
NVTVEGQMAGAHMRL	NRXN2	841	Q9P2S2
MSLNIGGAKGSMNRH	PI4KAP1	71	Q8N8J0
KNHEEEMKNMQGSSG	KRT24	281	Q2M2I5
QQHGDKMMSFDTRAP	GNA13	116	Q14344
NVEGLAHLMMGDQGK	NRXN1	261	Q9ULB1
NADDMDRIMTLGHKN	KIF3A	191	Q9Y496
RLQGEMAHIQVGQMT	GOLGA3	591	Q08378
IDHSNIGNKMLQAMG	RBM5	741	P52756
HQKMQFKSDGVMVGA	OTOP1	301	Q7RTM1
KMGTHSVQNGTVRMG	ARHGAP24	471	Q8N264
GSHAGNKLAMQEFMI	ENO1	156	P06733
KAQEGMREMSHSAEN	ATM	1126	Q13315
TAVHKANIMRMSDGL	IDH3A	196	P50213
NAALGQEMGSRDHMK	TTC26	326	A0AVF1
QEMGSRDHMKIAQQF	TTC26	331	A0AVF1
QHQEVRGKMMSGHVE	HS1BP3	26	Q53T59
MVHDIKNNEGGIMNK	BLNK	21	Q8WV28
MLENVLASHSKMQGA	CCDC150	686	Q8NCX0
GHNFARVKMQVTMSL	DOCK6	1496	Q96HP0
HLQVDGGMTNNKVLM	GK2	421	Q14410
GKMGDSTLEEMIQQH	BTAF1	321	O14981
GANNMPKQVEVRMHD	SLC1A2	6	P43004
SVGMTRNGDLGAMKH	CEP85	126	Q6P2H3
RGLAVNMVDSKHSMN	DDX19B	436	Q9UMR2
SLAKREVNHQNMGMN	HOXD10	56	P28358
TGDRKQGLHSMNMME	BMPR2	176	Q13873
GKMDGLMVVSGRRHN	DIP2C	791	Q9Y2E4
VLAARHQAQGDMATM	CYP11A1	356	P05108
GNLHGLIMNEDTMTN	HEPHL1	976	Q6MZM0
RVNDAMNMGHTAKQV	COQ9	276	O75208
MNMGHTAKQVKSTGE	COQ9	281	O75208
GSHAGNKLAMQEFMI	ENO3	156	P13929
SDGHAMKVAMGMQKQ	CCDC158	721	Q5M9N0
GLAVNMVDSKHSMNI	DDX19A	436	Q9NUU7
TRQVFSMAAMNKEGG	SAMD1	401	Q6SPF0
GVAHNNLMAMAQETG	C4A	1211	P0C0L4
MHLLQMQALKEGQGG	FOCAD	106	Q5VW36
NANMVGLANLHAMGI	PRPF3	226	O43395
RLTNSMMMHGRNNGK	RPS5	71	P46782
MNGDHMVLGSSVTDK	TAS2R60	1	P59551
NMHQMTDGLDKPGQI	SLC6A1	196	P30531
MKAEGGDHSMINLSV	TMEM170B	1	Q5T4T1
AAGMGHQARGMSLQS	FNBP4	846	Q8N3X1
GGHVQMVQRAMKDLT	ALOX5	431	P09917
MRFGMLKDHQAVTGN	PIWIL2	256	Q8TC59
PGRNGAQMMVHIVFK	IQCA1L	601	A6NCM1
HTGRRNMLAGKQEAM	FYB2	426	Q5VWT5
IMAMVKAGGSRQDCH	ADSL	386	P30566
HPNNAQLGMAVMRAG	SMYD1	386	Q8NB12
QGHGKANTMVALMNV	WHAMM	206	Q8TF30
LEHGRQFMDNMSGGK	MED13	1236	Q9UHV7
FHMGGNMELKAENSI	SGCB	241	Q16585
MSLNIGRAKGSMNRH	PI4KAP2	71	A4QPH2
KTGFLHNGRAMGNMR	ERRFI1	16	Q9UJM3
KVAMHILNNGRFGMA	ACADVL	331	P49748
MGIGHRVKSINNPDM	ACLY	971	P53396
GGKNTMMRSHGVSVL	ALK	746	Q9UM73
QGEDNMETEHGSKMR	NCAPG2	76	Q86XI2
RNRTPMGHMKQLDVA	TP53TG5	191	Q9Y2B4
QGQKRFQDMMGHGSD	XRCC6	126	P12956
RDGMMSHGQLKSVPQ	ZNF19	111	P17023
GVGKSAMTMQFISHR	RIT1	31	Q92963
DAGHAGVSANMMKKR	SPIN1	16	Q9Y657
LKMMANGGIRDHVGQ	SPATA20	301	Q8TB22
LANMGGTVAHKIMQK	RBM17	231	Q96I25
MESIHNKMRGAGNDI	WDR72	931	Q3MJ13
SGKAVAMMHQERKFN	SERPINB7	201	O75635
DNMKQMIFRGGLSHA	TBC1D15	336	Q8TC07
KDDGNMMKVLRGHQN	WSB1	201	Q9Y6I7
AMNLSGRRGSKGHMN	WNK1	2261	Q9H4A3
TAQAKAGNLMSAMLH	PTCD1	366	O75127
RNMKMERNHLGATLN	ZNF557	131	Q8N988
NGDTKSMVMDHRGQP	SEMA6D	751	Q8NFY4
QVMNKTRKIMEHGGA	SULF1	61	Q8IWU6
GKKHQRNLGMSMRVE	ZMAT2	101	Q96NC0
TAIMKEVHGNDVDGM	MYOZ2	16	Q9NPC6
GSNVHRIKSMFLQMG	PPP1R9B	51	Q96SB3
GMQAGTDTLEMQHAK	NEBL	461	O76041