Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	potassium:chloride symporter activity	SLC12A6 SLC12A4 SLC12A7	3.27e-06	9	69	3	GO:0015379
GeneOntologyMolecularFunction	ammonium channel activity	SLC12A6 SLC12A4 SLC12A7	8.50e-06	12	69	3	GO:0008519
GeneOntologyMolecularFunction	chloride:monoatomic cation symporter activity	SLC12A6 SLC12A4 SLC12A7	6.66e-05	23	69	3	GO:0015377
GeneOntologyMolecularFunction	monoatomic anion:monoatomic cation symporter activity	SLC12A6 SLC12A4 SLC12A7	9.70e-05	26	69	3	GO:0015296
GeneOntologyMolecularFunction	G protein-coupled opioid receptor activity	OPRD1 OPRK1	2.44e-04	7	69	2	GO:0004985
GeneOntologyMolecularFunction	GTPase activator activity	DOCK1 ARHGAP32 RIN3 NF1 ADGRB3 NCKAP1L	4.04e-04	279	69	6	GO:0005096
GeneOntologyMolecularFunction	solute:monoatomic cation symporter activity	SLC12A6 SLC12A4 SLC12A7 SLC1A1	7.69e-04	119	69	4	GO:0015294
GeneOntologyMolecularFunction	G protein-coupled receptor activity	OR56A5 ADGRB3 OR1E1 TACR3 CMKLR1 OR56A4 OR52P1 GRM8 OPRD1 OPRK1	8.73e-04	884	69	10	GO:0004930
GeneOntologyMolecularFunction	chloride transmembrane transporter activity	SLC12A6 SLC12A4 SLC12A7 SLC1A1	9.24e-04	125	69	4	GO:0015108
GeneOntologyMolecularFunction	active transmembrane transporter activity	SLC12A6 SLC12A4 ABCG2 SLC12A7 SLC1A1 SLC9C2 ABCA9	1.28e-03	477	69	7	GO:0022804
GeneOntologyMolecularFunction	nucleoside-triphosphatase regulator activity	DOCK1 ARHGAP32 RIN3 CCDC88A NF1 ADGRB3 NCKAP1L	1.81e-03	507	69	7	GO:0060589
GeneOntologyMolecularFunction	GTPase regulator activity	DOCK1 ARHGAP32 RIN3 CCDC88A NF1 ADGRB3 NCKAP1L	1.81e-03	507	69	7	GO:0030695
GeneOntologyMolecularFunction	symporter activity	SLC12A6 SLC12A4 SLC12A7 SLC1A1	1.81e-03	150	69	4	GO:0015293
GeneOntologyMolecularFunction	monoatomic anion transmembrane transporter activity	SLC12A6 SLC12A4 SLC12A7 SLC1A1	1.86e-03	151	69	4	GO:0008509
GeneOntologyMolecularFunction	enzyme activator activity	DOCK1 ARHGAP32 RIN3 CCDC88A NF1 ADGRB3 CCNB1 NCKAP1L	1.86e-03	656	69	8	GO:0008047
GeneOntologyMolecularFunction	transmembrane signaling receptor activity	NRXN2 PTPRM OR56A5 ADGRB3 OR1E1 TACR3 CMKLR1 OR56A4 OR52P1 GRM8 OPRD1 OPRK1	2.14e-03	1353	69	12	GO:0004888
GeneOntologyMolecularFunction	potassium ion transmembrane transporter activity	SLC12A6 SLC12A4 SLC12A7 SLC9C2	2.67e-03	167	69	4	GO:0015079
GeneOntologyMolecularFunction	inorganic anion transmembrane transporter activity	SLC12A6 SLC12A4 SLC12A7 SLC1A1	2.91e-03	171	69	4	GO:0015103
GeneOntologyMolecularFunction	secondary active transmembrane transporter activity	SLC12A6 SLC12A4 SLC12A7 SLC1A1 SLC9C2	3.59e-03	296	69	5	GO:0015291
GeneOntologyBiologicalProcess	ammonium import across plasma membrane	SLC12A6 SLC12A4 SLC12A7	1.37e-07	4	68	3	GO:0140157
GeneOntologyBiologicalProcess	observational learning	NF1 FOXP2 NRXN2	2.84e-06	9	68	3	GO:0098597
GeneOntologyBiologicalProcess	ammonium transmembrane transport	SLC12A6 SLC12A4 SLC12A7	9.57e-06	13	68	3	GO:0072488
GeneOntologyBiologicalProcess	behavior	NF1 FOXP2 NRXN2 LMX1B GLI3 ADGRB3 PEX13 TACR3 SLC1A1 UNC79 OPRD1 OPRK1	3.06e-05	891	68	12	GO:0007610
GeneOntologyBiologicalProcess	vocalization behavior	FOXP2 NRXN2 GLI3	6.60e-05	24	68	3	GO:0071625
GeneOntologyBiologicalProcess	learning	NF1 FOXP2 NRXN2 ADGRB3 SLC1A1 OPRK1	7.07e-05	212	68	6	GO:0007612
GeneOntologyBiologicalProcess	chloride ion homeostasis	SLC12A6 SLC12A4 SLC12A7	7.48e-05	25	68	3	GO:0055064
GeneOntologyBiologicalProcess	monoatomic anion homeostasis	SLC12A6 SLC12A4 SLC12A7	1.06e-04	28	68	3	GO:0055081
GeneOntologyBiologicalProcess	smooth muscle tissue development	NF1 FOXP2 EFEMP2	1.18e-04	29	68	3	GO:0048745
GeneOntologyBiologicalProcess	conditioned place preference	SLC1A1 OPRK1	1.59e-04	6	68	2	GO:1990708
GeneOntologyBiologicalProcess	feeding behavior	PEX13 TACR3 UNC79 OPRD1 OPRK1	1.96e-04	162	68	5	GO:0007631
GeneOntologyBiologicalProcess	vocal learning	FOXP2 NRXN2	2.23e-04	7	68	2	GO:0042297
GeneOntologyBiologicalProcess	imitative learning	FOXP2 NRXN2	2.23e-04	7	68	2	GO:0098596
GeneOntologyBiologicalProcess	learning or memory	NF1 FOXP2 NRXN2 LMX1B ADGRB3 SLC1A1 OPRK1	2.25e-04	373	68	7	GO:0007611
GeneOntologyBiologicalProcess	potassium ion homeostasis	SLC12A6 SLC12A4 SLC12A7	2.46e-04	37	68	3	GO:0055075
GeneOntologyBiologicalProcess	cell volume homeostasis	SLC12A6 SLC12A4 SLC12A7	3.59e-04	42	68	3	GO:0006884
GeneOntologyCellularComponent	sperm principal piece	AKAP4 AKAP3 CATSPERG	3.96e-04	44	68	3	GO:0097228
GeneOntologyCellularComponent	sperm flagellum	AKAP4 AKAP3 TACR3 CATSPERG DNAH8	6.63e-04	214	68	5	GO:0036126
GeneOntologyCellularComponent	nucleotide-excision repair complex	ERCC3 RAD23B	7.95e-04	13	68	2	GO:0000109
GeneOntologyCellularComponent	sperm fibrous sheath	AKAP4 AKAP3	7.95e-04	13	68	2	GO:0035686
GeneOntologyCellularComponent	transcription preinitiation complex	GTF2B ERCC3	1.07e-03	15	68	2	GO:0097550
GeneOntologyCellularComponent	9+2 motile cilium	AKAP4 AKAP3 TACR3 CATSPERG DNAH8	1.07e-03	238	68	5	GO:0097729
GeneOntologyCellularComponent	sperm midpiece	AKAP4 AKAP3 TACR3	1.19e-03	64	68	3	GO:0097225
Domain	KCL_cotranspt	SLC12A6 SLC12A4 SLC12A7	1.53e-07	4	64	3	IPR000076
Domain	SLC12A_fam	SLC12A6 SLC12A4 SLC12A7	1.33e-06	7	64	3	IPR004842
Domain	SLC12_C	SLC12A6 SLC12A4 SLC12A7	2.12e-06	8	64	3	IPR018491
Domain	SLC12	SLC12A6 SLC12A4 SLC12A7	2.12e-06	8	64	3	PF03522
Domain	KCC1	SLC12A6 SLC12A4	1.16e-05	2	64	2	IPR000622
Domain	AKAP_110	AKAP4 AKAP3	1.16e-05	2	64	2	IPR020799
Domain	AKAP_110	AKAP4 AKAP3	1.16e-05	2	64	2	SM00807
Domain	AKAP_110_C	AKAP4 AKAP3	3.46e-05	3	64	2	IPR018292
Domain	AA-permease/SLC12A_dom	SLC12A6 SLC12A4 SLC12A7	5.64e-05	22	64	3	IPR004841
Domain	AA_permease	SLC12A6 SLC12A4 SLC12A7	5.64e-05	22	64	3	PF00324
Domain	Opioid_rcpt	OPRD1 OPRK1	6.90e-05	4	64	2	IPR001418
Domain	SPHK1-interactor_AKAP_110	AKAP4 AKAP3	6.90e-05	4	64	2	IPR008382
Domain	AKAP_110	AKAP4 AKAP3	6.90e-05	4	64	2	PF05716
Domain	RII_binding_1	AKAP4 AKAP3	1.15e-04	5	64	2	PF10522
Domain	RII_binding_1	AKAP4 AKAP3	1.15e-04	5	64	2	IPR018459
Domain	SEA	MUC16 MUC3A	1.02e-03	14	64	2	SM00200
Domain	SH3_1	DOCK1 STAM2 ARHGAP32 PEX13	2.42e-03	164	64	4	PF00018
Domain	SH3_9	DOCK1 ARHGAP32 PEX13	2.43e-03	78	64	3	PF14604
Domain	SEA	MUC16 MUC3A	2.79e-03	23	64	2	PS50024
Domain	SEA_dom	MUC16 MUC3A	2.79e-03	23	64	2	IPR000082
Domain	SH3	DOCK1 STAM2 ARHGAP32 PEX13	6.43e-03	216	64	4	SM00326
Domain	SH3	DOCK1 STAM2 ARHGAP32 PEX13	6.43e-03	216	64	4	PS50002
Domain	SH3_domain	DOCK1 STAM2 ARHGAP32 PEX13	6.86e-03	220	64	4	IPR001452
Domain	CYCLIN	GTF2B CCNB1	7.51e-03	38	64	2	SM00385
Domain	GPCR_Rhodpsn_7TM	OR56A5 OR1E1 TACR3 CMKLR1 OR56A4 OPRD1 OPRK1	7.83e-03	670	64	7	IPR017452
Domain	7tm_1	OR56A5 OR1E1 TACR3 CMKLR1 OR56A4 OPRD1 OPRK1	8.26e-03	677	64	7	PF00001
Domain	-	GTF2B CCNB1	8.29e-03	40	64	2	1.10.472.10
Domain	EGF_3	NRXN2 EFEMP2 MUC3A PGAP6	8.61e-03	235	64	4	PS50026
Domain	EGF	NRXN2 EFEMP2 MUC3A PGAP6	8.61e-03	235	64	4	SM00181
Domain	G_PROTEIN_RECEP_F1_1	OR56A5 OR1E1 TACR3 CMKLR1 OR56A4 OPRD1 OPRK1	8.79e-03	685	64	7	PS00237
Domain	G_PROTEIN_RECEP_F1_2	OR56A5 OR1E1 TACR3 CMKLR1 OR56A4 OPRD1 OPRK1	9.19e-03	691	64	7	PS50262
Domain	GPCR_Rhodpsn	OR56A5 OR1E1 TACR3 CMKLR1 OR56A4 OPRD1 OPRK1	9.26e-03	692	64	7	IPR000276
Domain	Cyclin-like	GTF2B CCNB1	9.54e-03	43	64	2	IPR013763
Pathway	REACTOME_CATION_COUPLED_CHLORIDE_COTRANSPORTERS	SLC12A6 SLC12A4 SLC12A7	1.84e-06	7	54	3	M27339
Pathway	REACTOME_CATION_COUPLED_CHLORIDE_COTRANSPORTERS	SLC12A6 SLC12A4 SLC12A7	1.84e-06	7	54	3	MM15081
Pubmed	A dominant negative mutant of the KCC1 K-Cl cotransporter: both N- and C-terminal cytoplasmic domains are required for K-Cl cotransport activity.	SLC12A6 SLC12A4 SLC12A7	7.47e-09	3	69	3	11551954
Pubmed	Insulin-like growth factor 1 stimulates KCl cotransport, which is necessary for invasion and proliferation of cervical cancer and ovarian cancer cells.	SLC12A6 SLC12A4 SLC12A7	7.47e-09	3	69	3	15262997
Pubmed	K-Cl cotransporter gene expression during human and murine erythroid differentiation.	SLC12A6 SLC12A4 SLC12A7	7.47e-09	3	69	3	21733850
Pubmed	Influence of K-Cl cotransporter activity on activation of volume-sensitive Cl- channels in human osteoblasts.	SLC12A6 SLC12A4 SLC12A7	2.99e-08	4	69	3	12637262
Pubmed	Disruption of KCC2 reveals an essential role of K-Cl cotransport already in early synaptic inhibition.	SLC12A6 SLC12A4 SLC12A7	4.16e-07	8	69	3	11395011
Pubmed	The WNK-regulated SPAK/OSR1 kinases directly phosphorylate and inhibit the K+-Cl- co-transporters.	SLC12A6 SLC12A4 SLC12A7	4.16e-07	8	69	3	24393035
Pubmed	Similar effects of all WNK3 variants on SLC12 cotransporters.	SLC12A6 SLC12A4 SLC12A7	4.16e-07	8	69	3	21613606
Pubmed	Cation chloride cotransporters interact with the stress-related kinases Ste20-related proline-alanine-rich kinase (SPAK) and oxidative stress response 1 (OSR1).	SLC12A6 SLC12A4 SLC12A7	4.16e-07	8	69	3	12386165
Pubmed	Cation-chloride cotransporters and neuronal function.	SLC12A6 SLC12A4 SLC12A7	6.22e-07	9	69	3	19323993
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	SULF2 CCDC88A NRXN2 VPS13C TTLL4 ADGRB3 ZBTB5 XPO4 CACHD1	1.03e-06	529	69	9	14621295
Pubmed	Genome-wide characterization of Foxa2 targets reveals upregulation of floor plate genes and repression of ventrolateral genes in midbrain dopaminergic progenitors.	FOXP2 LMX1B KLF5 FOXA1	1.99e-06	45	69	4	22696295
Pubmed	Phospho-regulation, nucleotide binding and ion access control in potassium-chloride cotransporters.	SLC12A6 SLC12A4	3.88e-06	2	69	2	34031912
Pubmed	The seventh transmembrane domains of the delta and kappa opioid receptors have different accessibility patterns and interhelical interactions.	OPRD1 OPRK1	3.88e-06	2	69	2	16331961
Pubmed	Identification of kappa- and delta-opioid receptor transcripts in immune cells.	OPRD1 OPRK1	3.88e-06	2	69	2	7649271
Pubmed	Anti-nociception mediated by a κ opioid receptor agonist is blocked by a δ receptor agonist.	OPRD1 OPRK1	3.88e-06	2	69	2	24923251
Pubmed	Cloning and functional comparison of kappa and delta opioid receptors from mouse brain.	OPRD1 OPRK1	3.88e-06	2	69	2	8393575
Pubmed	μ-Opioid receptor antibody reveals tissue-dependent specific staining and increased neuronal μ-receptor immunoreactivity at the injured nerve trunk in mice.	OPRD1 OPRK1	3.88e-06	2	69	2	24278116
Pubmed	SLC12A ion transporter mutations in sporadic and familial human congenital hydrocephalus.	SLC12A6 SLC12A7	3.88e-06	2	69	2	31393094
Pubmed	Regulations of opioid dependence by opioid receptor types.	OPRD1 OPRK1	3.88e-06	2	69	2	11316510
Pubmed	G-protein-coupled receptor heterodimerization modulates receptor function.	OPRD1 OPRK1	3.88e-06	2	69	2	10385123
Pubmed	Disruption of erythroid K-Cl cotransporters alters erythrocyte volume and partially rescues erythrocyte dehydration in SAD mice.	SLC12A6 SLC12A4	3.88e-06	2	69	2	17510708
Pubmed	The OPRD1 and OPRK1 loci in alcohol or drug dependence: OPRD1 variation modulates substance dependence risk.	OPRD1 OPRK1	3.88e-06	2	69	2	17622222
Pubmed	Cloning and characterization of KCC3 and KCC4, new members of the cation-chloride cotransporter gene family.	SLC12A6 SLC12A7	3.88e-06	2	69	2	10347194
Pubmed	Role of kappa- and delta-opioid receptors in the antinociceptive effect of oxytocin in formalin-induced pain response in mice.	OPRD1 OPRK1	3.88e-06	2	69	2	16712978
Pubmed	Genetic disruption of KCC cotransporters in a mouse model of thalassemia intermedia.	SLC12A6 SLC12A4	3.88e-06	2	69	2	31835175
Pubmed	Neuroprotective role of FOXA1 in Parkinson's disease: Involvements of NF1 transcription activation and MAPK signaling pathway inhibition.	NF1 FOXA1	3.88e-06	2	69	2	38143008
Pubmed	Lack of AKAP3 disrupts integrity of the subcellular structure and proteome of mouse sperm and causes male sterility.	AKAP4 AKAP3	3.88e-06	2	69	2	31969357
Pubmed	A common variant in DRD3 receptor is associated with autism spectrum disorder.	SLC12A6 FOXP2 GRM8 OPRD1 OPRK1	5.81e-06	128	69	5	19058789
Pubmed	Rare independent mutations in renal salt handling genes contribute to blood pressure variation.	SLC12A6 SLC12A4 SLC12A7	1.12e-05	22	69	3	18391953
Pubmed	Isolation and molecular characterization of AKAP110, a novel, sperm-specific protein kinase A-anchoring protein.	AKAP4 AKAP3	1.16e-05	3	69	2	10319321
Pubmed	Association between human opioid receptor genes polymorphisms and pressure pain sensitivity in females*.	OPRD1 OPRK1	1.16e-05	3	69	2	19032295
Pubmed	Combined genetic disruption of K-Cl cotransporters and Gardos channel KCNN4 rescues erythrocyte dehydration in the SAD mouse model of sickle cell disease.	SLC12A6 SLC12A4	1.16e-05	3	69	2	31352162
Pubmed	The delta agonists DPDPE and deltorphin II recruit predominantly mu receptors to produce thermal analgesia: a parallel study of mu, delta and combinatorial opioid receptor knockout mice.	OPRD1 OPRK1	1.16e-05	3	69	2	15090050
Pubmed	Quantitative autoradiography of mu-,delta- and kappa1 opioid receptors in kappa-opioid receptor knockout mice.	OPRD1 OPRK1	1.16e-05	3	69	2	10082819
Pubmed	Cell-specific actions of HIV-Tat and morphine on opioid receptor expression in glia.	OPRD1 OPRK1	1.16e-05	3	69	2	18338799
Pubmed	Effects of opioid receptor gene variation on targeted nalmefene treatment in heavy drinkers.	OPRD1 OPRK1	1.16e-05	3	69	2	18537939
Pubmed	Acute antinociceptive responses in single and combinatorial opioid receptor knockout mice: distinct mu, delta and kappa tones.	OPRD1 OPRK1	1.16e-05	3	69	2	12603260
Pubmed	Long-term alterations in mu, delta and kappa opioidergic receptors following middle cerebral artery occlusion in mice.	OPRD1 OPRK1	1.16e-05	3	69	2	17676326
Pubmed	Searching for evidence of genetic mediation of opioid withdrawal by opioid receptor gene polymorphisms.	OPRD1 OPRK1	1.16e-05	3	69	2	26692286
Pubmed	IGF-1 upregulates electroneutral K-Cl cotransporter KCC3 and KCC4 which are differentially required for breast cancer cell proliferation and invasiveness.	SLC12A6 SLC12A7	1.16e-05	3	69	2	17133354
Pubmed	Opioid receptor gene (OPRM1, OPRK1, and OPRD1) variants and response to naltrexone treatment for alcohol dependence: results from the VA Cooperative Study.	OPRD1 OPRK1	1.16e-05	3	69	2	17374034
Pubmed	Oxytocin Is a Positive Allosteric Modulator of κ-Opioid Receptors but Not δ-Opioid Receptors in the G Protein Signaling Pathway.	OPRD1 OPRK1	1.16e-05	3	69	2	34685631
Pubmed	Immunosuppression by delta-opioid antagonist naltrindole: delta- and triple mu/delta/kappa-opioid receptor knockout mice reveal a nonopioid activity.	OPRD1 OPRK1	1.16e-05	3	69	2	11504820
Pubmed	No evidence for G-protein-coupled epsilon receptor in the brain of triple opioid receptor knockout mouse.	OPRD1 OPRK1	1.16e-05	3	69	2	15178356
Pubmed	Autoradiography of opioid and ORL1 ligands in opioid receptor triple knockout mice.	OPRD1 OPRK1	1.16e-05	3	69	2	12431223
Pubmed	The efficacy of Dynorphin fragments at the κ, μ and δ opioid receptor in transfected HEK cells and in an animal model of unilateral peripheral inflammation.	OPRD1 OPRK1	1.16e-05	3	69	2	28049031
Pubmed	Erythroid-specific inactivation of Slc12a6/Kcc3 by EpoR promoter-driven Cre expression reduces K-Cl cotransport activity in mouse erythrocytes.	SLC12A6 SLC12A4	1.16e-05	3	69	2	35274823
Pubmed	Modelling the PKPD of oxycodone in experimental pain - Impact of opioid receptor polymorphisms.	OPRD1 OPRK1	1.16e-05	3	69	2	26946441
Pubmed	Nociception increases during opioid infusion in opioid receptor triple knock-out mice.	OPRD1 OPRK1	1.16e-05	3	69	2	17544222
Pubmed	Homozygous loss-of-function mutations in FSIP2 cause male infertility with asthenoteratospermia.	AKAP4 AKAP3	1.16e-05	3	69	2	30745215
Pubmed	Endogenous opioid receptor genes and alcohol dependence among Taiwanese Han.	OPRD1 OPRK1	1.16e-05	3	69	2	14745298
Pubmed	Pharmacological characterization of the cloned kappa-, delta-, and mu-opioid receptors.	OPRD1 OPRK1	1.16e-05	3	69	2	8114680
Pubmed	Opioid receptor characterisation of neuronally stimulated isolated human vas deferens.	OPRD1 OPRK1	1.16e-05	3	69	2	22752269
Pubmed	Improgan, a cimetidine analog, induces morphine-like antinociception in opioid receptor-knockout mice.	OPRD1 OPRK1	1.16e-05	3	69	2	11032994
Pubmed	Systemic morphine treatment derails normal uterine receptivity, leading to embryo implantation failure in mice.	OPRD1 OPRK1	1.16e-05	3	69	2	25855262
Pubmed	Opioid receptors: from binding sites to visible molecules in vivo.	OPRD1 OPRK1	1.16e-05	3	69	2	18718480
Pubmed	Distinct mu, delta, and kappa opioid receptor mechanisms underlie low sociability and depressive-like behaviors during heroin abstinence.	OPRD1 OPRK1	1.16e-05	3	69	2	24874714
Pubmed	Molecular evidence for a role for K(+)-Cl(-) cotransporters in the kidney.	SLC12A6 SLC12A7	1.16e-05	3	69	2	24089410
Pubmed	Motivational effects of cannabinoids are mediated by mu-opioid and kappa-opioid receptors.	OPRD1 OPRK1	1.16e-05	3	69	2	11826143
Pubmed	Multiple OPR genes influence personality traits in substance dependent and healthy subjects in two American populations.	OPRD1 OPRK1	1.16e-05	3	69	2	18213616
Pubmed	Controlling opioid receptor functional selectivity by targeting distinct subpockets of the orthosteric site.	OPRD1 OPRK1	1.16e-05	3	69	2	33555255
Pubmed	Enhanced humoral response in kappa-opioid receptor knockout mice.	OPRD1 OPRK1	1.16e-05	3	69	2	12507774
Pubmed	Neurofilament proteins and cAMP pathway in brains of mu-, delta- or kappa-opioid receptor gene knock-out mice: effects of chronic morphine administration.	OPRD1 OPRK1	1.16e-05	3	69	2	14975676
Pubmed	Ammonium transport and pH regulation by K(+)-Cl(-) cotransporters.	SLC12A6 SLC12A7	1.16e-05	3	69	2	12657561
Pubmed	Heterodimerization of mu and delta opioid receptors: A role in opiate synergy.	OPRD1 OPRK1	1.16e-05	3	69	2	11069979
Pubmed	Human chromosome 11 DNA sequence and analysis including novel gene identification.	NRXN2 EFEMP2 OR56A5 FADS2B	2.00e-05	80	69	4	16554811
Pubmed	A Multipronged Unbiased Strategy Guides the Development of an Anti-EGFR/EPHA2-Bispecific Antibody for Combination Cancer Therapy.	SLC12A6 STAM2 ARHGAP32 CCDC88A PTPRM CACHD1 SLC12A7	2.05e-05	421	69	7	36976175
Pubmed	Tlx1/3 and Ptf1a control the expression of distinct sets of transmitter and peptide receptor genes in the developing dorsal spinal cord.	TACR3 GRM8 OPRD1 OPRK1	2.10e-05	81	69	4	22723691
Pubmed	Nuclear protein CBP is a coactivator for the transcription factor CREB.	GTF2B GLI3	2.32e-05	4	69	2	7913207
Pubmed	Multiple opioid receptor-like genes are identified in diverse vertebrate phyla.	OPRD1 OPRK1	2.32e-05	4	69	2	8941707
Pubmed	Krüppel-like factor 5 promotes mitosis by activating the cyclin B1/Cdc2 complex during oncogenic Ras-mediated transformation.	KLF5 CCNB1	2.32e-05	4	69	2	16102754
Pubmed	The xeroderma pigmentosum group C protein complex XPC-HR23B plays an important role in the recruitment of transcription factor IIH to damaged DNA.	ERCC3 RAD23B	2.32e-05	4	69	2	10734143
Pubmed	Interactions of opioid and chemokine receptors: oligomerization of mu, kappa, and delta with CCR5 on immune cells.	OPRD1 OPRK1	2.32e-05	4	69	2	12413885
Pubmed	Developmental expression of the mu, kappa, and delta opioid receptor mRNAs in mouse.	OPRD1 OPRK1	2.32e-05	4	69	2	9502813
Pubmed	Deregulated expression of Kruppel-like factors in acute myeloid leukemia.	KLF5 KLF3	2.32e-05	4	69	2	21470678
Pubmed	Differential dependencies of human RNA polymerase II promoters on TBP, TAF1, TFIIB and XPB.	GTF2B ERCC3	2.32e-05	4	69	2	35947745
Pubmed	Activation of delta-, kappa-, and mu-opioid receptors induces phosphorylation of tuberin in transfected HEK 293 cells and native cells.	OPRD1 OPRK1	2.32e-05	4	69	2	16053916
Pubmed	Quantitative autoradiographic mapping of the ORL1, mu-, delta- and kappa-receptors in the brains of knockout mice lacking the ORL1 receptor gene.	OPRD1 OPRK1	2.32e-05	4	69	2	11430857
Pubmed	A Dual Noradrenergic Mechanism for the Relief of Neuropathic Allodynia by the Antidepressant Drugs Duloxetine and Amitriptyline.	OPRD1 OPRK1	2.32e-05	4	69	2	30249798
Pubmed	Genome-wide characterisation of Foxa1 binding sites reveals several mechanisms for regulating neuronal differentiation in midbrain dopamine cells.	FOXP2 LMX1B FOXA1	2.92e-05	30	69	3	25804738
Pubmed	Tangential Intrahypothalamic Migration of the Mouse Ventral Premamillary Nucleus and Fgf8 Signaling.	FOXP2 LMX1B FOXA1	3.23e-05	31	69	3	34095148
Pubmed	Regulation of arcuate neurons coexpressing kisspeptin, neurokinin B, and dynorphin by modulators of neurokinin 3 and κ-opioid receptors in adult male mice.	TACR3 OPRK1	3.86e-05	5	69	2	23744642
Pubmed	CABYR isoforms expressed in late steps of spermiogenesis bind with AKAPs and ropporin in mouse sperm fibrous sheath.	AKAP4 AKAP3	3.86e-05	5	69	2	20731842
Pubmed	Transcriptional activation domain of human BTEB2, a GC box-binding factor.	GTF2B KLF5	3.86e-05	5	69	2	9089417
Pubmed	Variations in opioid receptor genes in neonatal abstinence syndrome.	OPRD1 OPRK1	3.86e-05	5	69	2	26233486
Pubmed	Human spermatozoa contain multiple targets for protein S-nitrosylation: an alternative mechanism of the modulation of sperm function by nitric oxide?	AKAP4 AKAP3	3.86e-05	5	69	2	17683036
Pubmed	A-kinase anchoring protein 4 binding proteins in the fibrous sheath of the sperm flagellum.	AKAP4 AKAP3	3.86e-05	5	69	2	12606363
Pubmed	Identification and characterization of novel candidate compounds targeting 6- and 7-transmembrane μ-opioid receptor isoforms.	OPRD1 OPRK1	3.86e-05	5	69	2	33782947
Pubmed	Sonic hedgehog signaling proteins and ATP-binding cassette G2 are aberrantly expressed in diffuse large B-cell lymphoma.	GLI3 ABCG2	3.86e-05	5	69	2	19593328
Pubmed	Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV.	SLC12A6 STAM2 NF1 GPAA1 SLC12A4 PTPRM WDR83OS PEX13 SLC12A7 RAD23B	4.45e-05	1061	69	10	33845483
Pubmed	Genetic susceptibility to heroin addiction: a candidate gene association study.	OPRD1 OPRK1	5.79e-05	6	69	2	18518925
Pubmed	Opioid receptor gene expression in dopamine transporter knock-out mice in adult and during development.	OPRD1 OPRK1	5.79e-05	6	69	2	12044478
Pubmed	Expression of opioid receptors and ligands in pregnant mouse uterus and placenta.	OPRD1 OPRK1	5.79e-05	6	69	2	9746745
Pubmed	Epigenetic silencing of Kruppel like factor-3 increases expression of pro-metastatic miR-182.	NF1 KLF3	5.79e-05	6	69	2	26314219
Pubmed	Cre fate mapping reveals lineage specific defects in neuronal migration with loss of Pitx2 function in the developing mouse hypothalamus and subthalamic nucleus.	FOXP2 LMX1B	5.79e-05	6	69	2	18206388
Pubmed	Combinatorial receptor codes for odors.	OR56A5 OR56A4	5.79e-05	6	69	2	10089886
Pubmed	Phox2a Defines a Developmental Origin of the Anterolateral System in Mice and Humans.	FOXP2 LMX1B TACR3	7.01e-05	40	69	3	33238113
Pubmed	BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.	DOCK1 STAM2 ARHGAP32 CCDC88A ISOC1 MAGI3 CACHD1 NUDC	7.94e-05	708	69	8	39231216
Pubmed	Foxa1 is essential for development and functional integrity of the subthalamic nucleus.	FOXP2 FOXA1	8.09e-05	7	69	2	27934886
Pubmed	Preimplantation mouse embryo is a target for opioid ligand-receptor signaling.	OPRD1 OPRK1	1.08e-04	8	69	2	24855103
Interaction	NRN1 interactions	SLC12A6 SLC12A4 SLC12A7 SLC1A1	8.25e-06	40	65	4	int:NRN1
Interaction	RHOB interactions	DOCK1 SLC12A6 STAM2 ARHGAP32 CCDC88A NF1 SLC12A4 PTPRM CACHD1 SLC12A7 NUP160 CCNB1	1.34e-05	840	65	12	int:RHOB
Cytoband	14q32.12	RIN3 UNC79	8.80e-04	29	69	2	14q32.12
Cytoband	2p16.1	CCDC88A PEX13	1.07e-03	32	69	2	2p16.1
Cytoband	11p15.4	OR56A5 OR56A4 OR52P1	3.45e-03	200	69	3	11p15.4
GeneFamily	Opioid receptors	OPRD1 OPRK1	4.66e-05	4	51	2	245
GeneFamily	Olfactory receptors, family 56	OR56A5 OR56A4	2.77e-04	9	51	2	167
GeneFamily	Zinc fingers C2H2-type\|Kruppel like factors	KLF5 KLF3	1.16e-03	18	51	2	624
GeneFamily	CD molecules\|Mucins	MUC16 MUC3A	1.58e-03	21	51	2	648
GeneFamily	General transcription factors\|Xeroderma pigmentosum complementation groups\|DNA helicases\|ERCC excision repair associated	GTF2B ERCC3	2.25e-03	25	51	2	565
GeneFamily	Zinc fingers MYND-type\|A-kinase anchoring proteins	AKAP4 AKAP3	3.02e-03	29	51	2	396
GeneFamily	Solute carriers	SLC12A6 SLC12A4 SLC12A7 SLC1A1 SLC9C2	5.00e-03	395	51	5	752
GeneFamily	Forkhead boxes	FOXP2 FOXA1	6.54e-03	43	51	2	508
Coexpression	MANNO_MIDBRAIN_NEUROTYPES_HDA	FOXP2 NRXN2 RTL9 MUC16 FOXA1 GRM8 UNC79 OPRK1 PDZRN4	6.22e-06	506	68	9	M39067
Coexpression	GSE17721_PAM3CSK4_VS_CPG_6H_BMDC_DN	FOXP2 PEX13 KLF3 ABCG2 GRM8 DNAH8	1.35e-05	200	68	6	M3864
Coexpression	MANNO_MIDBRAIN_NEUROTYPES_HDA1	CCDC88A FOXP2 NRXN2 LMX1B FOXA1 GRM8 UNC79 OPRK1 PDZRN4	1.95e-05	584	68	9	M39068
CoexpressionAtlas	ratio_induced-DefinitiveEndoderm_vs_StemCell_top-relative-expression-ranked_500	RIN3 SULF2 FOXP2 PTPRM LMX1B KLF5 EFEMP2 FOXA1 PDZRN4	1.28e-05	495	62	9	PCBC_ratio_DE_vs_SC_500
ToppCell	TCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma-Acinar_Adenocarcinoma-4\|TCGA-Prostate / Sample_Type by Project: Shred V9	RIN3 SULF2 SLC12A4 GLI3 EFEMP2 CACHD1	5.86e-07	195	69	6	5562665dd3beb70e2358aa32611a337bef5731c1
ToppCell	Parenchymal-NucSeq\|Parenchymal / Cell types per location group and 10X technology with lineage, and cell group designations	DOCK1 ARHGAP32 NF1 FOXP2 PTPRM MAGI3	6.41e-07	198	69	6	1996373bdccc55aac347d349bd22f6aad6d0c668
ToppCell	Tracheal-NucSeq\|Tracheal / Cell types per location group and 10X technology with lineage, and cell group designations	DOCK1 ARHGAP32 NF1 FOXP2 ADGRB3 MAGI3	6.60e-07	199	69	6	94b94b17ca18b8dc27b91da1f2ccf89e03cc7035
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_5-Exc_L4-6_RORB_HPCA\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SULF2 FOXP2 MAGI3 GRM8 PDZRN4	9.59e-06	183	69	5	c7e94fe3e7669db9304b249979fef7a69c30a143
ToppCell	15-Distal-Epithelial-Secretory_progenitor\|Distal / Age, Tissue, Lineage and Cell class	KLF5 CAPS MAGI3 FOXA1 OPRK1	1.09e-05	188	69	5	9a64fb07de611de38d6f24673feb3b81a5e85384
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-Adaptive_/_Maladaptive_/_Repairing_Fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	FOXP2 KLF5 GLI3 ABCA9 PDZRN4	1.09e-05	188	69	5	ce85a56ac27a6432421dde93a1bafa8b943244b9
ToppCell	COVID-19-Heart-EC_3\|Heart / Disease (COVID-19 only), tissue and cell type	SULF2 PTPRM IFI44L CACHD1 SLC1A1	1.15e-05	190	69	5	78e7c502b0450c0b37652b1896a2a752fd8a2111
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SULF2 PTPRM ADGRB3 ABCG2 CACHD1	1.21e-05	192	69	5	c0e59e642b42c055cf73d029cf54d07d9b719359
ToppCell	PCW_05-06-Epithelial-Epithelial_airway\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	KLF5 FOXA1 GRM8 SLC1A1 OPRK1	1.24e-05	193	69	5	af6ec2c2ba92aef3e41531c3c7215b3300437bd9
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SULF2 PTPRM ADGRB3 ABCG2 CACHD1	1.24e-05	193	69	5	52e918884877b6659cdca0496390e440f73694a9
ToppCell	10x5'-GI_small-bowel-Lymphocytic_T_CD4\|GI_small-bowel / Manually curated celltypes from each tissue	DLGAP1 PTPRM MAGI3 KLF3 IFI44L	1.27e-05	194	69	5	4547b57669be5d4f0de55175802ee04372288a6a
ToppCell	PCW_05-06-Epithelial-Epithelial_airway-epi_proximal_secretory_(0)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	KLF5 FOXA1 GRM8 SLC1A1 OPRK1	1.27e-05	194	69	5	b19e16a76d7342ff9a665d19c9151652916f17d4
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SULF2 PTPRM ADGRB3 IFI44L CMKLR1	1.34e-05	196	69	5	023312af38f816a44b407e0daa32590d953caf99
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_no-steroids\|BALF-PFMC / Compartment, severity and other cell annotations on 10x 3' data (130k)	ARHGAP32 KLF5 MUC16 IFI44L FOXA1	1.37e-05	197	69	5	495bfdb40b640591fbbaaa99f419bb6468cef405
ToppCell	wk_08-11-Epithelial-Airway_epithelial_progenitor-epi-airway_progenitor_early\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	KLF5 MAGI3 FOXA1 GRM8 OPRK1	1.37e-05	197	69	5	4ae08ccb6f1da626c4f0fb0140a2811cb6e31ba1
ToppCell	Bronchus_Control_(B.)-Immune-TX-TRAM-2\|Bronchus_Control_(B.) / Sample group, Lineage and Cell type	CCDC88A IFI44L ABCG2 CMKLR1 NCKAP1L	1.37e-05	197	69	5	eecb693367510da20a6b1e9355e68785a1e3b85c
ToppCell	BL-critical-LOC-Epithelial\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	ARHGAP32 KLF5 CAPS MUC16 FOXA1	1.40e-05	198	69	5	6218a25b94d5fa2c69880539adf9c63bfe52dcd3
ToppCell	NS-critical-LOC-Epithelial\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	ARHGAP32 KLF5 CAPS MUC16 FOXA1	1.44e-05	199	69	5	d64adb68502be596ce55fb2cb63fe1cfa2c5f8ba
ToppCell	PSB-critical-LOC-Epithelial\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	ARHGAP32 KLF5 CAPS MUC16 FOXA1	1.44e-05	199	69	5	58dcb0eedafa8629585dc99e53147e2287f49689
ToppCell	NS-critical-d_07-13-Epithelial\|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	ARHGAP32 KLF5 CAPS MUC16 FOXA1	1.44e-05	199	69	5	b88a81cd2a89f4d27100c96ae4324dcee68daf83
ToppCell	mLN-(5)_Dendritic_cell-(54)_pDC\|mLN / shred on region, Cell_type, and subtype	SULF2 CCDC88A CMKLR1 OR56A4 OPRK1	1.44e-05	199	69	5	1e738219784a446ee8b0ddeb408e0050e1929e60
ToppCell	mLN-Dendritic_cell-pDC\|mLN / Region, Cell class and subclass	SULF2 CCDC88A CMKLR1 OR56A4 OPRK1	1.44e-05	199	69	5	54f1abb57af7bf8a8b82a38b933f257df3b5d8df
ToppCell	control-Epithelial\|control / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	ARHGAP32 KLF5 MUC16 KLF3 FOXA1	1.47e-05	200	69	5	f95bbb94e51ac28b1995026c599ec3a34e012916
ToppCell	NS-control-d_0-4-Epithelial\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	ARHGAP32 KLF5 MUC16 KLF3 FOXA1	1.47e-05	200	69	5	d014959891893b6d3854a471fba1dc50c6625a0a
ToppCell	Tracheal\|World / Cell types per location group and 10X technology with lineage, and cell group designations	ARHGAP32 FOXP2 KLF5 ADGRB3 MUC16	1.47e-05	200	69	5	682960e28542a3d6c119047cd0131941932cfdea
ToppCell	(54)_pDC\|World / shred on Cell_type and subtype	SULF2 CCDC88A CMKLR1 OR56A4 OPRK1	1.58e-05	203	69	5	b8ba3e51770ff7b45cd02472f3e63aa4d5816f6f
ToppCell	facs-Marrow-B-cells-3m-Myeloid-granulocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AKAP3 FOXA1 CATSPERG PDZRN4	6.10e-05	137	69	4	4dcb15de821439011df1bb0bbd7682d674bd725d
ToppCell	facs-Marrow-B-cells-3m-Myeloid-granulocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AKAP3 FOXA1 CATSPERG PDZRN4	6.10e-05	137	69	4	c05ceeb7b483324604cb3f647d2da2b3786071b1
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron-L6_CT-L6_CT_VISp_Krt80_Sla\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	SLC12A4 FOXP2 GRM8 PDZRN4	8.90e-05	151	69	4	f50c5ae9dae507df750df25e151b58685fec70ce
ToppCell	368C-Fibroblasts-Fibroblast-H-\|368C / Donor, Lineage, Cell class and subclass (all cells)	FOXP2 NRXN2 PTPRM CCNB1	9.13e-05	152	69	4	dbfb4d4de36ef9f5c7da1950baa915b12788685e
ToppCell	368C-Fibroblasts-Fibroblast-H\|368C / Donor, Lineage, Cell class and subclass (all cells)	FOXP2 NRXN2 PTPRM CCNB1	9.13e-05	152	69	4	9f3682da00fd627e80aa820ecc6f5fed23b9738a
ToppCell	10x_3'_v2v3-Neoplastic-Stem-like-NPC-like-NPC-like_OPC-D\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	FOXP2 LMX1B OPRD1 RAD23B	1.01e-04	156	69	4	27590a4d2b419644966f0037c67c761fc275e0aa
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-1M-Radial_glial-gliogenic/outer_RGCs_and_astrocytes\|Organoid-1M / Sample Type, Dataset, Time_group, and Cell type.	DOCK1 ARHGAP32 RIN3 CATSPERG	1.03e-04	157	69	4	2c1219ee19a6246a3b9f5c2c1a37f26ea934a822
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron-L6_CT\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	SLC12A4 FOXP2 ABCG2 GRM8	1.17e-04	162	69	4	58da6bc04cdac0002b0e6a751c96ff95e1a7f70f
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron-L6_CT-L6_CT_VISp_Ctxn3_Brinp3\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	SLC12A4 FOXP2 ABCG2 GRM8	1.19e-04	163	69	4	b0aa4a620bd58011225b42ea6dda04e3101ba342
ToppCell	facs-Lung-EPCAM-3m-Myeloid-Myeloid_Dendritic_Type_1\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SULF2 CCDC88A ABCA9 NCKAP1L	1.25e-04	165	69	4	2477b0f1a0ea26184cf3cc4a9ffcdfa825cbc615
ToppCell	facs-Aorta-Heart-3m-Mesenchymal-fibrocyte\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GRM8 PGAP6 OPRD1 NCKAP1L	1.25e-04	165	69	4	8a52f2dbcbd2bc1662b5e3fac381463fdcc3bf14
ToppCell	Substantia_nigra-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Th\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	LMX1B TACR3 FOXA1 OPRK1	1.28e-04	166	69	4	6a6ed5c7a43fee9a8a9be42dfa99303815b8e8ef
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell_prolif\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	GLI3 ADGRB3 IFI44L CMKLR1	1.28e-04	166	69	4	9d4b44eb56ad38c26aed73444edf389abca6bdf6
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_5-Exc_L5-6_RORB_LINC00320\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SULF2 FOXP2 MUC3A PDZRN4	1.34e-04	168	69	4	3db0453296914011b733b82234b3e8e45ebc86b6
ToppCell	TCGA-Endometrium-Solid_Tissue_Normal-Endometrium_normal_tissue-Endometrium-7\|TCGA-Endometrium / Sample_Type by Project: Shred V9	FOXP2 ABCG2 ABCA9 PDZRN4	1.34e-04	168	69	4	a97e8e07ba949b30805aeed5f60fa5e092b9d3d4
ToppCell	RA-01._Fibroblast_I\|RA / Chamber and Cluster_Paper	FOXP2 ADGRB3 CACHD1 ABCA9	1.37e-04	169	69	4	6373562ab3b1765060212a6a53d6543e7e942e80
ToppCell	facs-Marrow-T-cells-3m-Myeloid-promonocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SULF2 CCDC88A VPS13C ABCA9	1.40e-04	170	69	4	a78d9789c3e7c84a36e1bd380192d7aba4a4d443
ToppCell	facs-Marrow-T-cells-3m-Myeloid-monocyte_+_promonocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SULF2 CCDC88A VPS13C ABCA9	1.40e-04	170	69	4	ff68600b945b3a5437b14e5411b3db800d0ccbe5
ToppCell	droplet-Marrow-nan-3m-Myeloid-monocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SULF2 CCDC88A VPS13C ABCA9	1.44e-04	171	69	4	992df143d76f9e7fb1997a8996f61e941f0f9d4f
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Macrophage_Dendritic-Plasmacytoid_Dendritic_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SULF2 CCDC88A ADGRB3 CMKLR1	1.44e-04	171	69	4	af1c93eb75f45c042ea475d93db56e4da207e31f
ToppCell	10x5'-bone_marrow-Myeloid_Dendritic-DC2\|bone_marrow / Manually curated celltypes from each tissue	DOCK1 SULF2 CCDC88A FOXA1	1.47e-04	172	69	4	64928cea7e5b60e4bc4af016454b0173ebcc07c7
ToppCell	Mild-CD4+_T_Exhausted\|World / Disease group and Cell class	IFI44L FOXA1 SLC1A1 NCKAP1L	1.47e-04	172	69	4	efe68d9477aa873b1637ee689f298120303aa322
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Macrophage_Dendritic-Classical_Dendritic_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	RIN3 SULF2 CCDC88A NCKAP1L	1.50e-04	173	69	4	73f858f2c45d19b9ec8d99ac02c91551790f670c
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	FOXP2 KLF5 MAGI3 SLC1A1	1.50e-04	173	69	4	b799c06a6a5754668e789f70c0c8bc1508568575
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	MAGI3 CACHD1 OPRK1 PDZRN4	1.54e-04	174	69	4	bc978a2148a0261a4f9d1ca5479b707e224566be
ToppCell	facs-Marrow-KLS-18m-Myeloid-granulocytopoietic_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EFEMP2 MAGI3 DNAH8 CCNB1	1.54e-04	174	69	4	9d5dcd46cf346c381dea68ada6665f7fb68114a3
ToppCell	facs-Marrow-KLS-18m-Myeloid-granulocytopoietic_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EFEMP2 MAGI3 DNAH8 CCNB1	1.54e-04	174	69	4	53cec5c666c45278a71c21dd9c62a052a97e0fdf
ToppCell	facs-Lung-24m-Hematologic-myeloid-myeloid_dendritic_cell-myeloid_dendritic_type_1\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	RIN3 SULF2 CCDC88A NCKAP1L	1.60e-04	176	69	4	a85ad8b4815fde72edd5c900e882a0bc04033ea8
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_5-Exc_L5_RORB_LINC01202\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SULF2 FOXP2 CACHD1 PDZRN4	1.64e-04	177	69	4	b6476a91abd06b8271b4d0ad7431d24b44022b47
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_5-Exc_L4-6_RORB_HPCA\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SULF2 FOXP2 FADS2B PDZRN4	1.68e-04	178	69	4	f2766913de010b718ba3799996d658b8f499adc5
ToppCell	Posterior_cortex-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	FOXA1 OPRK1 CCNB1	1.68e-04	69	69	3	4831573a45ace5f06cd409f0e75bce838ed65a88
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4-Exc_L4-5_RORB_RPL31P31\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SULF2 FOXP2 SLC12A7 GRM8	1.71e-04	179	69	4	b35a7f8115c997c390201da01d7cb10b10769aec
ToppCell	Control-Epithelial_cells-AT2\|Control / group, cell type (main and fine annotations)	DLGAP1 FOXP2 MAGI3 CACHD1	1.75e-04	180	69	4	198b19e7910b4a8cc7e820c525ab357c7f99f578
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_5\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SULF2 FOXP2 MAGI3 PDZRN4	1.79e-04	181	69	4	6e8c5460021d3999daec58e3d6661a6fa998fd16
ToppCell	PCW_05-06-Epithelial-Epithelial_airway-epi_proximal_progenitor1_(6)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	FOXA1 GRM8 SLC1A1 OPRK1	1.86e-04	183	69	4	c5b10571599dc26476170b54b53f09c23e6b3117
ToppCell	Control-Epithelial_cells-Airway_mucous\|Control / group, cell type (main and fine annotations)	SULF2 KLF5 MUC16 MUC3A	1.86e-04	183	69	4	15d24a4fb1ffe6cbafbd54fcd7dde9ddcfbe03b2
ToppCell	B_cells-ABCs\|B_cells / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues	NRXN2 IFI44L SLC1A1 DNAH8	1.86e-04	183	69	4	bf9c6fe3ce4e44e4056027257eab8448c39c4fb8
ToppCell	COVID-19-Epithelial_cells-AT2\|COVID-19 / group, cell type (main and fine annotations)	DLGAP1 FOXP2 MAGI3 CACHD1	1.90e-04	184	69	4	369b82f793deab672204558ae4e112cfa5aa9ccc
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4-Exc_L4-5_RORB_RPL31P31\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SULF2 FOXP2 SLC12A7 GRM8	1.90e-04	184	69	4	9cc5c588f7c6631b3fb8a522214a09ca32947e72
ToppCell	facs-Limb_Muscle-Muscle_forelimb_and_hindlimb-18m-Endothelial-endothelial_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RIN3 PTPRM ABCG2 SLC1A1	1.94e-04	185	69	4	c3105978d971da7d0fad1a717ee29afee5ed6357
ToppCell	facs-Limb_Muscle-Muscle_forelimb_and_hindlimb-18m-Endothelial-nan\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RIN3 PTPRM ABCG2 SLC1A1	1.94e-04	185	69	4	4cfef50aeed5b3000ce5e864a41c13740b8267b1
ToppCell	facs-Limb_Muscle-Muscle_forelimb_and_hindlimb-18m-Endothelial\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RIN3 PTPRM ABCG2 SLC1A1	1.94e-04	185	69	4	09256c6f42f59b7eb89160b2ea706172a5b743be
ToppCell	COPD-Epithelial-Goblet\|World / Disease state, Lineage and Cell class	FOXP2 KLF5 MUC16 FOXA1	1.98e-04	186	69	4	d75fe7640a4b2c450c9759a1b3c3ef2a087f0092
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Macrophage_Dendritic-Classical_Dendritic_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	RIN3 SULF2 CCDC88A NCKAP1L	1.98e-04	186	69	4	305f1726b8b5add32f1c29c74991ff34f42e0da7
ToppCell	Smart-seq2-blood_(Smart-seq2)-myeloid-myeloid_monocytic-classical_monocyte\|blood_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	CCDC88A VPS13C MUC16 DNAH8	1.98e-04	186	69	4	23b8d51d20b05795a73892d3e20e0f9b6a207820
ToppCell	CF-Lymphoid-pDC\|Lymphoid / Disease state, Lineage and Cell class	DOCK1 SULF2 CCDC88A SLC12A7	2.02e-04	187	69	4	adc79e5804ab98006dbdf1d76ef0d8f85cc5cb0f
ToppCell	facs-Trachea-3m-Endothelial-endothelial_cell_of_trachea\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	RIN3 PTPRM ABCG2 SLC1A1	2.06e-04	188	69	4	20072a2a3f9ecbe727c850629f19420cf60e4bc5
ToppCell	facs-Trachea-3m-Endothelial\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	RIN3 PTPRM ABCG2 SLC1A1	2.06e-04	188	69	4	dd817059e1b4225e84733559f7839cc973b7dfd6
ToppCell	COVID-19-Epithelial_cells\|COVID-19 / group, cell type (main and fine annotations)	FOXP2 KLF5 MAGI3 SLC1A1	2.06e-04	188	69	4	c9cdee6f8d42ee69f5fb335f25084603c511bd29
ToppCell	facs-Trachea-3m-Endothelial-endothelial_cell_of_trachea-tracheal_endothelial_cell\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	RIN3 PTPRM ABCG2 SLC1A1	2.06e-04	188	69	4	6ab5ce8569f896a0fe7a76b8b4a83661e5499b8c
ToppCell	human_hepatoblastoma-Tumor_cells-T5\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	DOCK1 CACHD1 UNC79 PDZRN4	2.06e-04	188	69	4	b070a0667f1ee9b825b267b6c389b7c42fc436f9
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	KLF5 GLI3 ABCA9 PDZRN4	2.15e-04	190	69	4	efb757f11c2809e66ddb48a5c84f5433f111cb7c
ToppCell	facs-Trachea-3m-Endothelial-endothelial_cell_of_trachea-tracheal_endothelial_cell-tracheal_endothelial_cell_l10\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	RIN3 PTPRM ABCG2 SLC12A7	2.15e-04	190	69	4	2655df8c0883dd811fa7617301f9c4b0a4dd55ec
ToppCell	E15.5-Epithelial-alveolar_epithelial_cell-type_I_pneumocyte\|E15.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	FOXP2 KLF5 MAGI3 FOXA1	2.19e-04	191	69	4	402c341b00f98e8215458766b3c219fff8dcb447
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	FOXP2 MAGI3 CACHD1 SLC1A1	2.19e-04	191	69	4	ca5669bd6f4a17471acae3eb229f845cc2e08efa
ToppCell	Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)\|World / Lineage, Cell type, age group and donor	FOXP2 MAGI3 CACHD1 SLC1A1	2.19e-04	191	69	4	d3733c8c4bda70c4390e5601fdda6188a64be944
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PTPRM ADGRB3 IFI44L CMKLR1	2.24e-04	192	69	4	1ee4783051ec94ea94600f040edcb385fc4289f1
ToppCell	Epithelial\|World / Lineage, Cell type, age group and donor	FOXP2 KLF5 MAGI3 CACHD1	2.24e-04	192	69	4	499e8893afea5e6d3371e0bd018f7e86a524d669
ToppCell	COPD-Epithelial\|COPD / Disease state, Lineage and Cell class	FOXP2 KLF5 CAPS SLC1A1	2.24e-04	192	69	4	0644fad5df18f0021f6f49cca996d8cf47f972ff
ToppCell	PCW_05-06-Epithelial-Epithelial_airway-epi_proximal_progenitor2_(4)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	KLF5 MUC16 FOXA1 OPRK1	2.24e-04	192	69	4	c15841f35e24d6ef6ce2a9a6dc62e66efdc3d9d5
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PTPRM ADGRB3 IFI44L ABCG2	2.24e-04	192	69	4	25cb6cc6cbf8dc20139d938adfc02ed7a8c3dfb6
ToppCell	COVID-19-lung-Secretory\|COVID-19 / Disease (COVID-19 only), tissue and cell type	KLF5 MAGI3 CACHD1 FOXA1	2.24e-04	192	69	4	59261098ccb52306f837f632ebaea45b90ad30fe
ToppCell	COPD-Epithelial-Goblet\|COPD / Disease state, Lineage and Cell class	FOXP2 KLF5 MUC16 FOXA1	2.24e-04	192	69	4	93b2ca0a97776d28c7e8f1a0642c4b63a5554aab
ToppCell	Children_(3_yrs)-Immune-monocyte-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	RIN3 SULF2 CCDC88A NCKAP1L	2.28e-04	193	69	4	58e1930a1d80ad3729ab9604ac8ebf7308232a3d
ToppCell	LA\|World / Chamber and Cluster_Paper	FOXP2 GLI3 ABCA9 PDZRN4	2.28e-04	193	69	4	d4bf89437216baf489ea0239136dcedf3b6714af
ToppCell	RV-02._Fibroblast_II\|RV / Chamber and Cluster_Paper	FOXP2 ADGRB3 ABCA9 PDZRN4	2.33e-04	194	69	4	11c79a8c56ece42713b04b321982e41e239f07a5
ToppCell	droplet-Heart-nan-3m-Mesenchymal-fibroblast\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SULF2 FOXP2 CMKLR1 ABCA9	2.33e-04	194	69	4	ce32e60bcea1b8baf496ce9050832bc8c77d8434
ToppCell	Neuron-Postmitotic-Inhibitory_Neuron-MGE2\|World / Primary Cells by Cluster	CCDC88A NRXN2 PTPRM PDZRN4	2.33e-04	194	69	4	b42fd64b0fb95434a9e4e6586f31d26114a4074b
ToppCell	Neuron-Postmitotic-Inhibitory_Neuron-MGE2-10\|World / Primary Cells by Cluster	CCDC88A NRXN2 PTPRM PDZRN4	2.33e-04	194	69	4	81e7bc6516ab8d02ccd1c76a56a3533b788c27c8
ToppCell	LV-02._Fibroblast_II\|LV / Chamber and Cluster_Paper	FOXP2 ADGRB3 ABCA9 PDZRN4	2.33e-04	194	69	4	014d2feb5db2a6a35ef759761a41e466e108c3c1
ToppCell	droplet-Heart-nan-3m-Mesenchymal-fibroblast_of_cardiac_tissue\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SULF2 FOXP2 CMKLR1 ABCA9	2.33e-04	194	69	4	a1dc157148885cc8d3685ac81a1f4e3562aeecc9
ToppCell	PCW_07-8.5-Epithelial-Epithelial_airway-epi_proximal_progenitor2_(4)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	KLF5 FOXA1 GRM8 OPRK1	2.33e-04	194	69	4	6b286992d4bb56013c0ea5a7601d3476d806175a
ToppCell	LA-14._Fibroblast_III\|World / Chamber and Cluster_Paper	FOXP2 GLI3 ABCA9 PDZRN4	2.33e-04	194	69	4	803fa83ceada17c38ca9f933b888f7e7b0b90761
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SULF2 PTPRM ADGRB3 CMKLR1	2.33e-04	194	69	4	e55dc30e200c9f576804acb642175eb4fa9146b5
Drug	Potassium Chloride	SLC12A6 SLC12A4 SLC12A7	4.62e-07	6	66	3	DB00761
Drug	tilidine	ABCG2 OPRD1 OPRK1	5.02e-06	12	66	3	CID000030131
Drug	erinacine E	OPRD1 OPRK1	8.28e-06	2	66	2	CID005317180
Drug	((2-n-butyl-6,7-dichloro-2-cyclopentyl-2,3-dihydro-1-oxo-1H-inden-5-yl)oxy)acetic acid	SLC12A4 SLC12A7	8.28e-06	2	66	2	ctd:C095651
Drug	Dynorphin (1-11)	OPRD1 OPRK1	8.28e-06	2	66	2	CID003086114
Drug	(-)-EKC	OPRD1 OPRK1	8.28e-06	2	66	2	CID000042800
Drug	trefentanil	OPRD1 OPRK1	8.28e-06	2	66	2	CID000060727
Drug	2-aminooxazole	OPRD1 OPRK1	8.28e-06	2	66	2	CID000558521
Drug	MR-1353	OPRD1 OPRK1	8.28e-06	2	66	2	CID000197198
Drug	Tyr-w-mif-1	TACR3 OPRD1 OPRK1	1.03e-05	15	66	3	CID000132632
Drug	Bumetanide	SLC12A6 SLC12A4 SLC12A7	1.27e-05	16	66	3	ctd:D002034
Drug	Tyr-mif-1	TACR3 OPRD1 OPRK1	1.54e-05	17	66	3	CID000115085
Drug	Rapamycin; Down 200; 0.1uM; PC3; HT_HG-U133A	ARHGAP32 RIN3 NF1 TTLL4 SLC12A7 NUP160	2.17e-05	195	66	6	1207_DN
Drug	cyclorphan	OPRD1 OPRK1	2.48e-05	3	66	2	ctd:C084603
Drug	up hit	OPRD1 OPRK1	2.48e-05	3	66	2	CID000129713
Drug	TRK 820	OPRD1 OPRK1	2.48e-05	3	66	2	ctd:C111212
Drug	Oxycodone	OPRD1 OPRK1	2.48e-05	3	66	2	DB00497
Drug	Hydromorphone	OPRD1 OPRK1	2.48e-05	3	66	2	DB00327
Drug	Codeine	OPRD1 OPRK1	2.48e-05	3	66	2	DB00318
Drug	Carfentanil	OPRD1 OPRK1	2.48e-05	3	66	2	DB01535
Drug	Morphine	OPRD1 OPRK1	2.48e-05	3	66	2	DB00295
Drug	Hydrocodone	OPRD1 OPRK1	2.48e-05	3	66	2	ctd:D006853
Drug	3-Methylfentanyl	OPRD1 OPRK1	2.48e-05	3	66	2	DB01571
Drug	Alvimopan	OPRD1 OPRK1	2.48e-05	3	66	2	DB06274
Drug	dextrallorphan	OPRD1 OPRK1	2.48e-05	3	66	2	ctd:C044130
Drug	Heroin	OPRD1 OPRK1	2.48e-05	3	66	2	DB01452
Drug	3-Methylthiofentanyl	OPRD1 OPRK1	2.48e-05	3	66	2	DB01439
Drug	14-phenylpropoxymetopon	OPRD1 OPRK1	2.48e-05	3	66	2	ctd:C478565
Drug	morphine-7,8-oxide	OPRD1 OPRK1	2.48e-05	3	66	2	CID005491901
Drug	Levorphanol	OPRD1 OPRK1	2.48e-05	3	66	2	ctd:D007981
Drug	Levallorphan	OPRD1 OPRK1	2.48e-05	3	66	2	ctd:D007977
Drug	NSC612112	OPRD1 OPRK1	2.48e-05	3	66	2	CID000356432
Drug	NSC11411	OPRD1 OPRK1	2.48e-05	3	66	2	CID000408117
Drug	indolin-3-one	OPRD1 OPRK1	2.48e-05	3	66	2	CID000230915
Drug	naloxazine	OPRD1 OPRK1	2.48e-05	3	66	2	CID003081567
Drug	Buprenorphine	OPRD1 OPRK1	2.48e-05	3	66	2	DB00921
Drug	Levorphanol	OPRD1 OPRK1	2.48e-05	3	66	2	DB00854
Drug	Remifentanil	OPRD1 OPRK1	2.48e-05	3	66	2	DB00899
Drug	Nalbuphine	OPRD1 OPRK1	2.48e-05	3	66	2	DB00844
Drug	Fentanyl	OPRD1 OPRK1	2.48e-05	3	66	2	DB00813
Drug	Sufentanil	OPRD1 OPRK1	2.48e-05	3	66	2	DB00708
Drug	Ro 64-6198	OPRD1 OPRK1	2.48e-05	3	66	2	CID009844019
Drug	Propoxyphene	OPRD1 OPRK1	2.48e-05	3	66	2	DB00647
Drug	Butorphanol	OPRD1 OPRK1	2.48e-05	3	66	2	DB00611
Drug	Butorphanol	OPRD1 OPRK1	2.48e-05	3	66	2	ctd:D002077
Drug	3-deazacytidine	SLC12A6 GTF2B ERCC3 NF1 SLC12A4 LMX1B	2.95e-05	206	66	6	CID000001652
Drug	Dynorphins	OPRD1 OPRK1	4.95e-05	4	66	2	ctd:D004399
Drug	AC1L5BQM	OPRD1 OPRK1	4.95e-05	4	66	2	CID000174892
Drug	Diprenorphine	OPRD1 OPRK1	4.95e-05	4	66	2	DB01548
Drug	3B-b	OPRD1 OPRK1	4.95e-05	4	66	2	CID000533975
Drug	picenadol	OPRD1 OPRK1	4.95e-05	4	66	2	CID000053076
Drug	sulforhodamine B acid chloride	OPRD1 OPRK1	4.95e-05	4	66	2	CID000065223
Drug	Methadyl Acetate	OPRD1 OPRK1	4.95e-05	4	66	2	ctd:D008692
Drug	7-hydroxymitragynine	OPRD1 OPRK1	4.95e-05	4	66	2	ctd:C482678
Drug	Naltrexone	OPRD1 OPRK1	4.95e-05	4	66	2	DB00704
Drug	ifenprodil	GRM8 SLC1A1 OPRD1 OPRK1	5.41e-05	71	66	4	CID000003689
Drug	Barium	SLC12A4 SLC12A7 OPRD1 OPRK1	5.71e-05	72	66	4	ctd:D001464
Drug	chelerythrine	SLC12A6 SLC12A4 SLC12A7 GRM8 SLC1A1 OPRD1 OPRK1	7.73e-05	357	66	7	CID000002703
Drug	K 185	OPRD1 OPRK1	8.23e-05	5	66	2	CID005311198
Drug	AC1L2FKQ	OPRD1 OPRK1	8.23e-05	5	66	2	CID000020114
Drug	Tyr-tic-phe-phe-OH	OPRD1 OPRK1	8.23e-05	5	66	2	CID003035452
Drug	Dihydromorphine	OPRD1 OPRK1	8.23e-05	5	66	2	DB01565
Drug	ICI 197067	OPRD1 OPRK1	8.23e-05	5	66	2	CID003081077
Drug	metkephamid acetate	OPRD1 OPRK1	8.23e-05	5	66	2	CID005464183
Drug	R-84760	OPRD1 OPRK1	8.23e-05	5	66	2	CID000133035
Drug	Naloxone	OPRD1 OPRK1	8.23e-05	5	66	2	DB01183
Drug	DALECK	OPRD1 OPRK1	8.23e-05	5	66	2	CID015942760
Drug	GPA 1657	OPRD1 OPRK1	8.23e-05	5	66	2	CID000030503
Drug	oxymorphamine	OPRD1 OPRK1	8.23e-05	5	66	2	CID000134844
Drug	RLH-033	OPRD1 OPRK1	8.23e-05	5	66	2	CID000190867
Drug	mirfentanil	OPRD1 OPRK1	8.23e-05	5	66	2	CID000060697
Drug	Trichlormethiazide	SLC12A4 SLC12A7	8.23e-05	5	66	2	ctd:D014237
Drug	Sc 39566	OPRD1 OPRK1	8.23e-05	5	66	2	CID000130018
Drug	BRL 52537	OPRD1 OPRK1	8.23e-05	5	66	2	CID005244802
Drug	AC1L1TDW	OPRD1 OPRK1	8.23e-05	5	66	2	CID000060509
Drug	Mr2097	OPRD1 OPRK1	8.23e-05	5	66	2	CID005745592
Drug	trichlormethiazide	SLC12A6 STAM2 SLC12A4	1.09e-04	32	66	3	CID000005560
Drug	AC1L2TFU	OPRD1 OPRK1	1.23e-04	6	66	2	CID000128241
Drug	Etorphine	OPRD1 OPRK1	1.23e-04	6	66	2	DB01497
Drug	NIH10236	OPRD1 OPRK1	1.23e-04	6	66	2	CID006439828
Drug	DuP 747	OPRD1 OPRK1	1.23e-04	6	66	2	CID000132447
Drug	AC1L2OET	OPRD1 OPRK1	1.23e-04	6	66	2	CID000125331
Drug	AC1L3OP4	OPRD1 OPRK1	1.23e-04	6	66	2	CID000092720
Drug	beta-methyl-2',6'-dimethyltyrosine	OPRD1 OPRK1	1.23e-04	6	66	2	CID000189865
Drug	NSC612111	OPRD1 OPRK1	1.23e-04	6	66	2	CID000163346
Drug	AC1L1FBI	OPRD1 OPRK1	1.23e-04	6	66	2	CID000053641
Drug	Loperamide	OPRD1 OPRK1	1.23e-04	6	66	2	DB00836
Drug	KT-90	OPRD1 OPRK1	1.23e-04	6	66	2	CID005492465
Drug	RX8008M	OPRD1 OPRK1	1.23e-04	6	66	2	CID000162443
Drug	phenylquinone	TACR3 OPRD1 OPRK1	1.55e-04	36	66	3	CID000009688
Drug	Tyr-ala-phe-gly	OPRD1 OPRK1	1.72e-04	7	66	2	CID005487532
Drug	Dextropropoxyphene	OPRD1 OPRK1	1.72e-04	7	66	2	ctd:D011431
Drug	GR89696	OPRD1 OPRK1	1.72e-04	7	66	2	CID000003505
Drug	EET-HO	OPRD1 OPRK1	1.72e-04	7	66	2	CID000135928
Drug	Enkephalin, D-Penicillamine (2,5)-	OPRD1 OPRK1	1.72e-04	7	66	2	ctd:D020881
Drug	MET-CAMO	OPRD1 OPRK1	1.72e-04	7	66	2	CID006450159
Drug	AC1L2YDY	OPRD1 OPRK1	1.72e-04	7	66	2	CID000130992
Drug	phenylmorphan	OPRD1 OPRK1	1.72e-04	7	66	2	CID000146306
Drug	AC1Q6ZKG	OPRD1 OPRK1	1.72e-04	7	66	2	CID000031785
Drug	AC1L9PCU	OPRD1 OPRK1	1.72e-04	7	66	2	CID000451042
Disease	epilepsy (implicated_via_orthology)	SLC12A6 SLC12A4 SLC12A7 GRM8 NUDC SLC1A1	1.49e-06	163	64	6	DOID:1826 (implicated_via_orthology)
Disease	Colorectal Carcinoma	GTF2B NF1 KLF5 GLI3 AKAP3 ABCG2 DNAH8 ABCA9 PDZRN4	1.99e-05	702	64	9	C0009402
Disease	autistic disorder (is_implicated_in)	NF1 FOXP2 GRM8	1.05e-04	42	64	3	DOID:12849 (is_implicated_in)
Disease	Schizophrenia	DLGAP1 ARHGAP32 FOXP2 NRXN2 LMX1B KLF5 TACR3 GRM8 SLC1A1	1.16e-04	883	64	9	C0036341
Disease	drug use measurement	FOXP2 TACR3	1.29e-04	8	64	2	EFO_0007010
Disease	Cocaine Dependence	TACR3 DNAH8 OPRD1 OPRK1	2.41e-04	139	64	4	C0600427
Disease	polybrominated biphenyl measurement, gestational serum measurement, fetal genotype effect measurement, polybrominated diphenyl ether measurement	FOXP2 PTPRM	2.52e-04	11	64	2	EFO_0007959, EFO_0007961, EFO_0007962, EFO_0007964
Disease	5-oxoproline measurement	GPAA1 DNAH8	5.45e-04	16	64	2	EFO_0010988
Disease	cyclic adenosine monophosphate measurement	PTPRM ABCG2	6.17e-04	17	64	2	EFO_0010473
Disease	X-12063 measurement	DLGAP1 NF1 FOXP2 XPO4	7.23e-04	186	64	4	EFO_0021283
Disease	intraocular pressure measurement	GTF2B LMX1B KLF5 ISOC1 FOXA1 NUP160	8.23e-04	509	64	6	EFO_0004695
Disease	smoking status measurement	DLGAP1 STAM2 FOXP2 NRXN2 ADGRB3 CMKLR1 GRM8 DNAH8 UNC79	8.56e-04	1160	64	9	EFO_0006527
Disease	attention deficit hyperactivity disorder (is_implicated_in)	FOXP2 GRM8	8.58e-04	20	64	2	DOID:1094 (is_implicated_in)
Disease	aspartate aminotransferase measurement, serum alanine aminotransferase measurement, low density lipoprotein triglyceride measurement, body fat percentage, high density lipoprotein cholesterol measurement, sex hormone-binding globulin measurement	RIN3 SULF2 KLF3 UNC79 PDZRN4	1.17e-03	364	64	5	EFO_0004612, EFO_0004696, EFO_0004735, EFO_0004736, EFO_0007800, EFO_0009946
Disease	gastroesophageal reflux disease	FOXP2 GRM8 UNC79	1.39e-03	101	64	3	EFO_0003948
Disease	Antiglaucoma preparations and miotics use measurement	LMX1B NUP160	1.46e-03	26	64	2	EFO_0009944
Disease	neuroblastoma, cutaneous melanoma	XPO4 MAGI3	1.69e-03	28	64	2	EFO_0000389, EFO_0000621
Disease	Drug habituation	DOCK1 DNAH8 OPRD1	2.02e-03	115	64	3	C0013170
Disease	Substance-Related Disorders	DOCK1 DNAH8 OPRD1	2.02e-03	115	64	3	C0236969
Disease	Drug abuse	DOCK1 DNAH8 OPRD1	2.02e-03	115	64	3	C0013146
Disease	Drug Use Disorders	DOCK1 DNAH8 OPRD1	2.02e-03	115	64	3	C0013222
Disease	Drug Dependence	DOCK1 DNAH8 OPRD1	2.02e-03	115	64	3	C1510472
Disease	Substance Dependence	DOCK1 DNAH8 OPRD1	2.02e-03	115	64	3	C0038580
Disease	Substance Use Disorders	DOCK1 DNAH8 OPRD1	2.02e-03	115	64	3	C0038586
Disease	Organic Mental Disorders, Substance-Induced	DOCK1 DNAH8 OPRD1	2.02e-03	115	64	3	C0029231
Disease	Prescription Drug Abuse	DOCK1 DNAH8 OPRD1	2.02e-03	115	64	3	C4316881
Disease	Substance abuse problem	DOCK1 DNAH8 OPRD1	2.07e-03	116	64	3	C0740858
Disease	neuroimaging measurement	SULF2 CCDC88A NF1 FOXP2 GLI3 KLF3 ABCG2 RAD23B	2.12e-03	1069	64	8	EFO_0004346
Disease	Cocaine-Related Disorders	TACR3 DNAH8 OPRK1	2.12e-03	117	64	3	C0236736

Protein segments in the cluster

Peptide	Gene	Start	Entry
HSRMGSMFSSRMTED	CATSPERG	1131	Q6ZRH7
SASMNTDEEFVAMMT	CAPS	256	Q13938
MMAYSDTTMMSDDID	AKAP4	1	Q5JQC9
ERMMESDYIVMPRSS	ADGRB3	1301	O60242
TQERQYITSLMTMMG	ABCA9	246	Q8IUA7
YITSLMTMMGLRESA	ABCA9	251	Q8IUA7
FTLMMVAYSASSMAL	ABCG2	511	Q9UNQ0
MTQMEMSSLNTYIVR	CACHD1	716	Q5VU97
YMRAMSTISQVSEME	DLGAP1	441	O14490
SRSSEDTKQMMSSFM	WDR83OS	71	Q9Y284
MSSFMLSISAVVMSY	WDR83OS	81	Q9Y284
TGQSYENMVTEIMSM	RAD23B	186	P54727
TTDDDTMSEMKMGRY	PDZRN4	926	Q6ZMN7
LTMESCTFMVMAYDR	OR56A4	111	Q8NGH8
RLSSSSMMSESTQMT	MUC16	9941	Q8WXI7
ATSSRSMMDRMFALE	ISOC1	236	Q96CN7
MVSLSEEMENSSSSM	KLF3	166	P57682
SMSTTNMAIGDMSSL	GLI3	1551	P10071
TNSSMDFRNYMMRDE	MAGI3	276	Q5TCQ9
QRTYMSENAMGSTMV	GPAA1	46	O43292
FLNMSRSMTSQSRVM	IFI44L	371	Q53G44
FHQYRSMDSSMSMAD	KIAA1109	1376	Q2LD37
SMDSSMSMADSEAYF	KIAA1109	1381	Q2LD37
YRRSMSMNDLVQSMV	CCDC88A	1486	Q3V6T2
IQTTLTTYMDTSSMM	MUC3A	2821	Q02505
TEMSMVNIMYQTSLA	DNAH8	3696	Q96JB1
MMQESATETISNSSM	FOXP2	1	O15409
MSQRAYGLMMATTSR	NRXN2	761	Q9P2S2
MFAMTLEESAMLRYA	NCKAP1L	551	P55160
MASVGIAIYTSMMTS	PGAP6	701	Q9HCN3
MMESTVLLAMAFDRY	OR52P1	111	Q8NH57
MTYMTTTPATAQMST	ARHGAP32	1261	A7KAX9
SMSLSASVSLGMLYM	GRM8	821	O00222
TTSRDNTKYMLYMQM	IGHV8-51-1	86	P0DTE2
NMFTSIFTLTMMSVD	OPRD1	131	P41143
VYVTQMSHITMRMST	FADS2B	376	A8MWK0
LTMESCTFMIMAYDR	OR56A5	111	P0C7T3
TYMTMNTMTTSGNMT	FOXA1	46	P55317
ETMYMTVSIIDRFMQ	CCNB1	221	P14635
FRSINDMMSSMSDQT	DOCK1	776	Q14185
LYYDVTSSMTTELMM	MDH1B	91	Q5I0G3
TMSSMSGADDTVYME	ERCC3	746	P19447
EMVTMNSLMSYRASS	EFEMP2	416	O95967
YTYERTLMMEQRSQM	SLC12A6	986	Q9UHW9
FTYERTLMMEQRSQM	SLC12A7	921	Q9Y666
EMNMTEESFTAVMTT	SLC1A1	176	P43005
TMSSTRQEMTVMVNS	PTPRM	776	P28827
YSLEMMARQTSSTEM	RIN3	626	Q8TB24
SSTLKDTVMAMMYTV	OR1E1	266	P30953
NMFTSIFTLTMMSVD	OPRK1	141	P41145
TMFTEKMTTTASEAM	RTL9	626	Q8NET4
TYNTMAMHKDVDTSM	SESN1	386	Q9Y6P5
ASVSMMMDATFSAVY	PEX13	141	Q92968
RQSSMYTVTRMESMT	TACR3	396	P29371
SVTVDMSVIMEMSCY	NUP160	616	Q12769
SETRSMVEKMMYDQR	NUDC	281	Q9Y266
YTYERTLMMEQRSQM	SLC12A4	921	Q9UP95
MTYANSVVSDMMVSI	AKAP3	286	O75969
RSFTKMSSMNERTSM	CMKLR1	351	Q99788
AFAALIDMMYTSTLM	ZBTB5	76	O15062
IDMMYTSTLMLGESN	ZBTB5	81	O15062
LMYSLELGMTSMSSE	XPO4	1006	Q9C0E2
SQMSYEEMMTLTEQH	SAMD4B	321	Q5PRF9
YQNRRTMSSSDRAMM	GTF2B	101	Q00403
NTFMEFASVSNMMST	NF1	736	P21359
MGMSVDMSSYQNTTS	STAM2	481	O75886
LMETSMTDMSILSFF	VPS13C	3311	Q709C8
LSSYSDMIIDNMTMK	SLC9C2	1031	Q5TAH2
MVFSMAQPMASSSTE	TTLL4	166	Q14679
MSYAAERSMMSSYER	SON	1001	P18583
ERSMMSSYERSMMSY	SON	1006	P18583
SSYERSMMSYERSMM	SON	1011	P18583
SPMAERSMMSAYERS	SON	1026	P18583
RSMMSAYERSMMSAY	SON	1031	P18583
AYERSMMSAYERSMM	SON	1036	P18583
SPMAERSMMSAYERS	SON	1051	P18583
RSMMSAYERSMMSAY	SON	1056	P18583
AYERSMMSAYERSMM	SON	1061	P18583
MGADRSMMSSYSAAD	SON	1086	P18583
SMMSSYSAADRSMMS	SON	1091	P18583
RSMMSSYSAADRSMM	SON	1101	P18583
DRSMMSSYTADRSMM	SON	1111	P18583
SSYTADRSMMSMAAD	SON	1116	P18583
DRSMMSMAADSYTDS	SON	1121	P18583
TLMSVDDSMETIYNM	SULF2	286	Q8IWU5
LSASSMLMIAMQYTS	UNC79	221	Q9P2D8
TAAMDTLNVSMSAAM	KLF5	246	Q13887
EVLSSRMEGMMASYT	LMX1B	296	O60663