Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	acetyl-CoA carboxylase activity	ACACA ACACB	2.65e-06	2	33	2	GO:0003989
GeneOntologyMolecularFunction	CoA carboxylase activity	ACACA ACACB	3.96e-05	6	33	2	GO:0016421
GeneOntologyMolecularFunction	biotin binding	ACACA ACACB	3.96e-05	6	33	2	GO:0009374
GeneOntologyMolecularFunction	ligase activity, forming carbon-carbon bonds	ACACA ACACB	5.53e-05	7	33	2	GO:0016885
GeneOntologyMolecularFunction	inositol-polyphosphate 5-phosphatase activity	INPP5E INPP5B	7.37e-05	8	33	2	GO:0004445
GeneOntologyMolecularFunction	phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity	INPP5E INPP5B	1.18e-04	10	33	2	GO:0004439
GeneOntologyMolecularFunction	phosphatidylinositol-4,5-bisphosphate phosphatase activity	INPP5E INPP5B	1.73e-04	12	33	2	GO:0106019
GeneOntologyMolecularFunction	phosphatidylinositol phosphate 5-phosphatase activity	INPP5E INPP5B	2.04e-04	13	33	2	GO:0034595
GeneOntologyMolecularFunction	inositol trisphosphate phosphatase activity	INPP5E INPP5B	2.38e-04	14	33	2	GO:0046030
GeneOntologyMolecularFunction	ligand-gated monoatomic ion channel activity	TRPM4 TTYH3 ASIC1 ANO3	2.78e-04	193	33	4	GO:0015276
GeneOntologyMolecularFunction	lipid transporter activity	SLC22A9 ANO3 PLTP GRAMD1A	2.95e-04	196	33	4	GO:0005319
GeneOntologyMolecularFunction	ligand-gated channel activity	TRPM4 TTYH3 ASIC1 ANO3	3.01e-04	197	33	4	GO:0022834
GeneOntologyMolecularFunction	inositol phosphate phosphatase activity	INPP5E INPP5B	4.94e-04	20	33	2	GO:0052745
GeneOntologyMolecularFunction	intracellularly calcium-gated channel activity	TTYH3 ANO3	4.94e-04	20	33	2	GO:0141147
GeneOntologyMolecularFunction	intracellularly calcium-gated chloride channel activity	TTYH3 ANO3	4.94e-04	20	33	2	GO:0005229
GeneOntologyMolecularFunction	cholesterol transfer activity	PLTP GRAMD1A	7.15e-04	24	33	2	GO:0120020
GeneOntologyMolecularFunction	sterol transfer activity	PLTP GRAMD1A	7.76e-04	25	33	2	GO:0120015
GeneOntologyMolecularFunction	phosphatidylinositol bisphosphate phosphatase activity	INPP5E INPP5B	9.06e-04	27	33	2	GO:0034593
GeneOntologyMolecularFunction	transporter activity	SLC22A9 TRPM4 TTYH3 ASIC1 ANO3 PLTP GRAMD1A XPR1	9.58e-04	1289	33	8	GO:0005215
GeneOntologyMolecularFunction	phosphatidylinositol phosphate phosphatase activity	INPP5E INPP5B	1.12e-03	30	33	2	GO:0052866
GeneOntologyMolecularFunction	monoatomic ion-gated channel activity	TRPM4 ASIC1	1.20e-03	31	33	2	GO:0022839
GeneOntologyMolecularFunction	amide binding	CD1B ACACA ACACB PLTP	1.43e-03	299	33	4	GO:0033218
GeneOntologyMolecularFunction	oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor	SRD5A3 DUS3L	1.44e-03	34	33	2	GO:0016628
GeneOntologyMolecularFunction	gated channel activity	TRPM4 TTYH3 ASIC1 ANO3	2.15e-03	334	33	4	GO:0022836
GeneOntologyMolecularFunction	vitamin binding	ACACA ACACB SEC14L2	2.35e-03	161	33	3	GO:0019842
GeneOntologyMolecularFunction	inorganic anion transmembrane transporter activity	TTYH3 ANO3 XPR1	2.79e-03	171	33	3	GO:0015103
GeneOntologyMolecularFunction	ligand-gated monoatomic anion channel activity	TTYH3 ANO3	3.09e-03	50	33	2	GO:0099095
GeneOntologyMolecularFunction	sodium channel activity	TRPM4 ASIC1	3.34e-03	52	33	2	GO:0005272
GeneOntologyMolecularFunction	lipid transfer activity	PLTP GRAMD1A	3.99e-03	57	33	2	GO:0120013
GeneOntologyMolecularFunction	oxidoreductase activity, acting on the CH-CH group of donors	SRD5A3 DUS3L	4.71e-03	62	33	2	GO:0016627
GeneOntologyMolecularFunction	phospholipid transporter activity	ANO3 PLTP	6.64e-03	74	33	2	GO:0005548
GeneOntologyMolecularFunction	monoatomic ion channel activity	TRPM4 TTYH3 ASIC1 ANO3	6.65e-03	459	33	4	GO:0005216
GeneOntologyMolecularFunction	inorganic molecular entity transmembrane transporter activity	TRPM4 TTYH3 ASIC1 ANO3 XPR1	7.64e-03	758	33	5	GO:0015318
GeneOntologyMolecularFunction	chloride channel activity	TTYH3 ANO3	8.88e-03	86	33	2	GO:0005254
GeneOntologyMolecularFunction	nucleoside-triphosphatase regulator activity	TBC1D25 TBC1D15 ARHGEF40 TBC1D5	9.38e-03	507	33	4	GO:0060589
GeneOntologyMolecularFunction	GTPase regulator activity	TBC1D25 TBC1D15 ARHGEF40 TBC1D5	9.38e-03	507	33	4	GO:0030695
GeneOntologyMolecularFunction	channel activity	TRPM4 TTYH3 ASIC1 ANO3	1.06e-02	525	33	4	GO:0015267
GeneOntologyMolecularFunction	passive transmembrane transporter activity	TRPM4 TTYH3 ASIC1 ANO3	1.06e-02	526	33	4	GO:0022803
GeneOntologyMolecularFunction	GTPase activator activity	TBC1D25 TBC1D15 TBC1D5	1.08e-02	279	33	3	GO:0005096
GeneOntologyMolecularFunction	transmembrane transporter activity	SLC22A9 TRPM4 TTYH3 ASIC1 ANO3 XPR1	1.18e-02	1180	33	6	GO:0022857
GeneOntologyMolecularFunction	alcohol binding	GRAMD1A XPR1	1.23e-02	102	33	2	GO:0043178
GeneOntologyMolecularFunction	monoatomic anion channel activity	TTYH3 ANO3	1.25e-02	103	33	2	GO:0005253
GeneOntologyMolecularFunction	monocarboxylic acid binding	ACACA ACACB	1.35e-02	107	33	2	GO:0033293
GeneOntologyMolecularFunction	sulfur compound binding	ACACA ACACB PCIF1	1.60e-02	323	33	3	GO:1901681
GeneOntologyMolecularFunction	chloride transmembrane transporter activity	TTYH3 ANO3	1.81e-02	125	33	2	GO:0015108
GeneOntologyMolecularFunction	enzyme activator activity	TBC1D25 TBC1D15 TBC1D5 SEC14L2	2.22e-02	656	33	4	GO:0008047
GeneOntologyMolecularFunction	ligand-gated monoatomic cation channel activity	TRPM4 ASIC1	2.24e-02	140	33	2	GO:0099094
GeneOntologyBiologicalProcess	malonyl-CoA biosynthetic process	ACACA ACACB	2.48e-06	2	33	2	GO:2001295
GeneOntologyBiologicalProcess	malonyl-CoA metabolic process	ACACA ACACB	3.71e-05	6	33	2	GO:2001293
GeneOntologyCellularComponent	autophagosome	TBC1D25 TBC1D5 GRAMD1A	7.91e-04	119	32	3	GO:0005776
Domain	AcCoA_COase_cen	ACACA ACACB	3.03e-06	2	33	2	IPR013537
Domain	ACC_central	ACACA ACACB	3.03e-06	2	33	2	PF08326
Domain	Carboxyl_trans	ACACA ACACB	1.81e-05	4	33	2	PF01039
Domain	COA_CT_N	ACACA ACACB	1.81e-05	4	33	2	IPR011762
Domain	COA_CT_C	ACACA ACACB	1.81e-05	4	33	2	IPR011763
Domain	COA_CT_CTER	ACACA ACACB	1.81e-05	4	33	2	PS50989
Domain	Carboxyl_trans	ACACA ACACB	1.81e-05	4	33	2	IPR000022
Domain	COA_CT_NTER	ACACA ACACB	1.81e-05	4	33	2	PS50980
Domain	Biotin_COase_C	ACACA ACACB	3.02e-05	5	33	2	IPR005482
Domain	Biotin_BS	ACACA ACACB	3.02e-05	5	33	2	IPR001882
Domain	Biotin_carb_C	ACACA ACACB	3.02e-05	5	33	2	SM00878
Domain	Biotin_carb_C	ACACA ACACB	3.02e-05	5	33	2	PF02785
Domain	Biotin_carboxylation_dom	ACACA ACACB	3.02e-05	5	33	2	IPR011764
Domain	BIOTIN	ACACA ACACB	3.02e-05	5	33	2	PS00188
Domain	CPSASE_1	ACACA ACACB	3.02e-05	5	33	2	PS00866
Domain	BC	ACACA ACACB	3.02e-05	5	33	2	PS50979
Domain	Rudment_hybrid_motif	ACACA ACACB	4.52e-05	6	33	2	IPR011054
Domain	CPSASE_2	ACACA ACACB	4.52e-05	6	33	2	PS00867
Domain	CbamoylP_synth_lsu-like_ATP-bd	ACACA ACACB	6.32e-05	7	33	2	IPR005479
Domain	BC-like_N	ACACA ACACB	6.32e-05	7	33	2	IPR005481
Domain	Biotin_carb_N	ACACA ACACB	6.32e-05	7	33	2	PF00289
Domain	CPSase_L_D2	ACACA ACACB	6.32e-05	7	33	2	PF02786
Domain	TBC	TBC1D25 TBC1D15 TBC1D5	8.76e-05	49	33	3	SM00164
Domain	Biotin_lipoyl	ACACA ACACB	1.08e-04	9	33	2	PF00364
Domain	RabGAP-TBC	TBC1D25 TBC1D15 TBC1D5	1.11e-04	53	33	3	PF00566
Domain	TBC_RABGAP	TBC1D25 TBC1D15 TBC1D5	1.24e-04	55	33	3	PS50086
Domain	Rab-GTPase-TBC_dom	TBC1D25 TBC1D15 TBC1D5	1.24e-04	55	33	3	IPR000195
Domain	IPPc	INPP5E INPP5B	1.35e-04	10	33	2	IPR000300
Domain	Biotin_lipoyl	ACACA ACACB	1.35e-04	10	33	2	IPR000089
Domain	BIOTINYL_LIPOYL	ACACA ACACB	1.35e-04	10	33	2	PS50968
Domain	IPPc	INPP5E INPP5B	1.35e-04	10	33	2	SM00128
Domain	Single_hybrid_motif	ACACA ACACB	1.98e-04	12	33	2	IPR011053
Domain	-	ACACA ACACB	2.33e-04	13	33	2	3.40.50.20
Domain	ATP-grasp	ACACA ACACB	2.72e-04	14	33	2	IPR011761
Domain	PreATP-grasp_dom	ACACA ACACB	2.72e-04	14	33	2	IPR016185
Domain	ATP_GRASP	ACACA ACACB	2.72e-04	14	33	2	PS50975
Domain	-	ACACA ACACB	3.13e-04	15	33	2	3.30.1490.20
Domain	-	ACACA ACACB	4.55e-04	18	33	2	3.30.470.20
Domain	ATP_grasp_subdomain_1	ACACA ACACB	4.55e-04	18	33	2	IPR013815
Domain	-	ACACA ACACB	6.23e-04	21	33	2	3.90.226.10
Domain	ClpP/crotonase-like_dom	ACACA ACACB	6.23e-04	21	33	2	IPR029045
Domain	-	INPP5E INPP5B	9.58e-04	26	33	2	3.60.10.10
Domain	Exo_endo_phos	INPP5E INPP5B	9.58e-04	26	33	2	PF03372
Domain	Endo/exonuclease/phosphatase	INPP5E INPP5B	1.03e-03	27	33	2	IPR005135
Domain	ATP_grasp_subdomain_2	ACACA ACACB	1.36e-03	31	33	2	IPR013816
Pathway	REACTOME_STIMULI_SENSING_CHANNELS	TRPM4 TTYH3 ASIC1 ANO3	1.52e-05	99	22	4	MM14910
Pathway	REACTOME_STIMULI_SENSING_CHANNELS	TRPM4 TTYH3 ASIC1 ANO3	1.99e-05	106	22	4	M27200
Pathway	REACTOME_CHREBP_ACTIVATES_METABOLIC_GENE_EXPRESSION	ACACA ACACB	6.47e-05	8	22	2	M26991
Pathway	WP_BIOTIN_METABOLISM_INCLUDING_IMDS	ACACA ACACB	8.31e-05	9	22	2	M40064
Pathway	REACTOME_BIOTIN_TRANSPORT_AND_METABOLISM	ACACA ACACB	1.27e-04	11	22	2	M27086
Pathway	REACTOME_BIOTIN_TRANSPORT_AND_METABOLISM	ACACA ACACB	1.27e-04	11	22	2	MM14764
Pathway	REACTOME_ION_CHANNEL_TRANSPORT	TRPM4 TTYH3 ASIC1 ANO3	1.44e-04	176	22	4	MM15718
Pathway	REACTOME_ION_CHANNEL_TRANSPORT	TRPM4 TTYH3 ASIC1 ANO3	1.67e-04	183	22	4	M997
Pathway	REACTOME_CARNITINE_METABOLISM	ACACA ACACB	2.09e-04	14	22	2	M27098
Pathway	REACTOME_CARNITINE_METABOLISM	ACACA ACACB	2.09e-04	14	22	2	MM14788
Pathway	WP_HEREDITARY_LEIOMYOMATOSIS_AND_RENAL_CELL_CARCINOMA_PATHWAY	ACACA ACACB	4.34e-04	20	22	2	M39751
Pathway	WP_FATTY_ACID_BIOSYNTHESIS	ACACA ACACB	5.27e-04	22	22	2	M39440
Pathway	WP_FATTY_ACID_BIOSYNTHESIS	ACACA ACACB	5.77e-04	23	22	2	MM15885
Pathway	WP_GLYCOSYLATION_AND_RELATED_CONGENITAL_DEFECTS	ALG11 SRD5A3	6.82e-04	25	22	2	M39813
Pathway	KEGG_PROPANOATE_METABOLISM	ACACA ACACB	1.19e-03	33	22	2	M4086
Pathway	REACTOME_TBC_RABGAPS	TBC1D25 TBC1D15	1.34e-03	35	22	2	MM15494
Pathway	REACTOME_METABOLISM_OF_STEROIDS	SRD5A3 ACACA ACACB	1.69e-03	154	22	3	M27832
Pathway	KEGG_PYRUVATE_METABOLISM	ACACA ACACB	1.75e-03	40	22	2	M7934
Pathway	REACTOME_ACTIVATION_OF_GENE_EXPRESSION_BY_SREBF_SREBP	ACACA ACACB	1.93e-03	42	22	2	M27172
Pathway	REACTOME_TBC_RABGAPS	TBC1D25 TBC1D15	2.11e-03	44	22	2	M27748
Pathway	REACTOME_METABOLISM_OF_LIPIDS	SIN3B SRD5A3 ACACA ACACB INPP5E	2.29e-03	620	22	5	MM15193
Pathway	KEGG_INOSITOL_PHOSPHATE_METABOLISM	INPP5E INPP5B	3.17e-03	54	22	2	M3896
Pathway	REACTOME_REGULATION_OF_CHOLESTEROL_BIOSYNTHESIS_BY_SREBP_SREBF	ACACA ACACB	3.28e-03	55	22	2	M27001
Pathway	REACTOME_TRANSPORT_OF_SMALL_MOLECULES	TRPM4 TTYH3 ASIC1 ANO3 PLTP	3.44e-03	681	22	5	MM14985
Pathway	WP_NGLYCAN_BIOSYNTHESIS	ALG11 SRD5A3	3.52e-03	57	22	2	M48051
Pathway	REACTOME_TRANSPORT_OF_SMALL_MOLECULES	TRPM4 TTYH3 ASIC1 ANO3 PLTP	4.80e-03	736	22	5	M27287
Pathway	WP_AMPACTIVATED_PROTEIN_KINASE_SIGNALING	ACACA ACACB	4.83e-03	67	22	2	M39630
Pathway	REACTOME_METABOLISM_OF_LIPIDS	SIN3B SRD5A3 ACACA ACACB INPP5E	5.40e-03	757	22	5	M27451
Pathway	WP_LEPTIN_SIGNALING	ACACA ACACB	6.18e-03	76	22	2	M39491
Pathway	KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	INPP5E INPP5B	6.18e-03	76	22	2	M9052
Pathway	REACTOME_DISEASES_OF_METABOLISM	ALG11 SRD5A3 ACACA	6.61e-03	250	22	3	M27554
Pathway	REACTOME_BIOSYNTHESIS_OF_THE_N_GLYCAN_PRECURSOR_DOLICHOL_LIPID_LINKED_OLIGOSACCHARIDE_LLO_AND_TRANSFER_TO_A_NASCENT_PROTEIN	ALG11 SRD5A3	6.66e-03	79	22	2	M897
Pubmed	Blocking AMPK signalling to acetyl-CoA carboxylase increases cisplatin-induced acute kidney injury and suppresses the benefit of metformin.	ACACA ACACB	9.28e-07	2	34	2	36076520
Pubmed	De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cells.	ACACA ACACB	9.28e-07	2	34	2	25282359
Pubmed	AMPK-dependent inhibitory phosphorylation of ACC is not essential for maintaining myocardial fatty acid oxidation.	ACACA ACACB	9.28e-07	2	34	2	25001074
Pubmed	Acetyl-CoA carboxylase rewires cancer metabolism to allow cancer cells to survive inhibition of the Warburg effect by cetuximab.	ACACA ACACB	9.28e-07	2	34	2	27693630
Pubmed	AMPK signaling to acetyl-CoA carboxylase is required for fasting- and cold-induced appetite but not thermogenesis.	ACACA ACACB	9.28e-07	2	34	2	29433631
Pubmed	Structure and regulation of acetyl-CoA carboxylase genes of metazoa.	ACACA ACACB	9.28e-07	2	34	2	15749055
Pubmed	The subcellular localization of acetyl-CoA carboxylase 2.	ACACA ACACB	9.28e-07	2	34	2	10677481
Pubmed	Inhibition of hepatic lipogenesis enhances liver tumorigenesis by increasing antioxidant defence and promoting cell survival.	ACACA ACACB	9.28e-07	2	34	2	28290443
Pubmed	Effects of PKB/Akt inhibitors on insulin-stimulated lipogenesis and phosphorylation state of lipogenic enzymes in white adipose tissue.	ACACA ACACB	9.28e-07	2	34	2	32215608
Pubmed	Inhibition of Acetyl-CoA Carboxylase by Phosphorylation or the Inhibitor ND-654 Suppresses Lipogenesis and Hepatocellular Carcinoma.	ACACA ACACB	9.28e-07	2	34	2	30244972
Pubmed	Hormonal regulation of acetyl-CoA carboxylase isoenzyme gene transcription.	ACACA ACACB	9.28e-07	2	34	2	20139635
Pubmed	Activity and structure of human acetyl-CoA carboxylase targeted by a specific inhibitor.	ACACA ACACB	9.28e-07	2	34	2	29772612
Pubmed	Inhibition of Acetyl-CoA Carboxylase 1 (ACC1) and 2 (ACC2) Reduces Proliferation and De Novo Lipogenesis of EGFRvIII Human Glioblastoma Cells.	ACACA ACACB	9.28e-07	2	34	2	28081256
Pubmed	Susceptibility of podocytes to palmitic acid is regulated by fatty acid oxidation and inversely depends on acetyl-CoA carboxylases 1 and 2.	ACACA ACACB	9.28e-07	2	34	2	24338821
Pubmed	Phosphorylation of Acetyl-CoA Carboxylase by AMPK Reduces Renal Fibrosis and Is Essential for the Anti-Fibrotic Effect of Metformin.	ACACA ACACB	9.28e-07	2	34	2	29976587
Pubmed	Acetyl-CoA carboxylase inhibition by ND-630 reduces hepatic steatosis, improves insulin sensitivity, and modulates dyslipidemia in rats.	ACACA ACACB	9.28e-07	2	34	2	26976583
Pubmed	Genetic inhibition of hepatic acetyl-CoA carboxylase activity increases liver fat and alters global protein acetylation.	ACACA ACACB	9.28e-07	2	34	2	24944901
Pubmed	Differential activation of recombinant human acetyl-CoA carboxylases 1 and 2 by citrate.	ACACA ACACB	2.78e-06	3	34	2	18455495
Pubmed	Acetyl CoA Carboxylase Inhibition Reduces Hepatic Steatosis but Elevates Plasma Triglycerides in Mice and Humans: A Bedside to Bench Investigation.	ACACA ACACB	2.78e-06	3	34	2	28877461
Pubmed	AMPK activation by SC4 inhibits noradrenaline-induced lipolysis and insulin-stimulated lipogenesis in white adipose tissue.	ACACA ACACB	2.78e-06	3	34	2	34668531
Pubmed	Induced polymerization of mammalian acetyl-CoA carboxylase by MIG12 provides a tertiary level of regulation of fatty acid synthesis.	ACACA ACACB	2.78e-06	3	34	2	20457939
Pubmed	Acetyl-CoA carboxylase 1 and 2 inhibition ameliorates steatosis and hepatic fibrosis in a MC4R knockout murine model of nonalcoholic steatohepatitis.	ACACA ACACB	2.78e-06	3	34	2	31990961
Pubmed	AMPK-ACC signaling modulates platelet phospholipids and potentiates thrombus formation.	ACACA ACACB	2.78e-06	3	34	2	30018077
Pubmed	Macrophage acetyl-CoA carboxylase regulates acute inflammation through control of glucose and lipid metabolism.	ACACA ACACB	2.78e-06	3	34	2	36417534
Pubmed	The Na+/Glucose Cotransporter Inhibitor Canagliflozin Activates AMPK by Inhibiting Mitochondrial Function and Increasing Cellular AMP Levels.	ACACA ACACB	2.78e-06	3	34	2	27381369
Pubmed	Hepatic de novo lipogenesis is present in liver-specific ACC1-deficient mice.	ACACA ACACB	2.78e-06	3	34	2	17210641
Pubmed	Acetyl-coenzyme A carboxylase alpha gene variations may be associated with the direct effects of some antipsychotics on triglyceride levels.	ACACA ACACB	2.78e-06	3	34	2	19846279
Pubmed	Exploring genetic variations that may be associated with the direct effects of some antipsychotics on lipid levels.	ACACA ACACB	2.78e-06	3	34	2	18031993
Pubmed	Specific pattern of LKB1 and phospho-acetyl-CoA carboxylase protein immunostaining in human normal tissues and lung carcinomas.	ACACA ACACB	2.78e-06	3	34	2	17521700
Pubmed	Acetyl CoA Carboxylase Inhibition Reduces Hepatic Steatosis but Elevates Plasma Triglycerides in Mice and Humans: A Bedside to Bench Investigation.	ACACA ACACB	2.78e-06	3	34	2	28768177
Pubmed	Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin.	ACACA ACACB	5.56e-06	4	34	2	24185692
Pubmed	Crystal structure of Spot 14, a modulator of fatty acid synthesis.	ACACA ACACB	5.56e-06	4	34	2	20952656
Pubmed	Hepatic malonyl-CoA synthesis restrains gluconeogenesis by suppressing fat oxidation, pyruvate carboxylation, and amino acid availability.	ACACA ACACB	5.56e-06	4	34	2	38447582
Pubmed	Acetyl-CoA carboxylase 1 is a suppressor of the adipocyte thermogenic program.	ACACA ACACB	9.26e-06	5	34	2	37163372
Pubmed	Metformin-induced increases in GDF15 are important for suppressing appetite and promoting weight loss.	ACACA ACACB	9.26e-06	5	34	2	32694673
Pubmed	TRB3 links the E3 ubiquitin ligase COP1 to lipid metabolism.	ACACA ACACB	9.26e-06	5	34	2	16794074
Pubmed	Identification and characterization of a novel Tre-2/Bub2/Cdc16 (TBC) protein that possesses Rab3A-GAP activity.	TBC1D25 TBC1D15 TBC1D5	1.03e-05	43	34	3	19077034
Pubmed	The AMPK-HOXB9-KRAS axis regulates lung adenocarcinoma growth in response to cellular energy alterations.	ACACA ACACB	2.59e-05	8	34	2	36001969
Pubmed	SIRT1 regulates Tat-induced HIV-1 transactivation through activating AMP-activated protein kinase.	ACACA ACACB	4.15e-05	10	34	2	19720090
Pubmed	HDAC1/NFκB pathway is involved in curcumin inhibiting of Tat-mediated long terminal repeat transactivation.	ACACA ACACB	6.08e-05	12	34	2	21344388
Pubmed	AMP-activated protein kinase (AMPK) activity is not required for neuronal development but regulates axogenesis during metabolic stress.	ACACA ACACB	6.08e-05	12	34	2	21436046
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	PHLDB3 TRPM4 TBC1D25 ARHGEF40 TTYH3 ACACA INPP5E	8.14e-05	1105	34	7	35748872
Pubmed	AMP-activated protein kinase phosphorylates retinoblastoma protein to control mammalian brain development.	ACACA ACACB	1.93e-04	21	34	2	19217427
Pubmed	Genetic variability of the fatty acid synthase pathway is not associated with prostate cancer risk in the European Prospective Investigation on Cancer (EPIC).	ACACA ACACB	2.12e-04	22	34	2	20965718
Pubmed	ATP-citrate lyase deficiency in the mouse.	ACACA ACACB	2.32e-04	23	34	2	14662765
Pubmed	Rab GTPase-activating proteins in autophagy: regulation of endocytic and autophagy pathways by direct binding to human ATG8 modifiers.	TBC1D25 TBC1D5	3.21e-04	27	34	2	22354992
Pubmed	WWP2 is an E3 ubiquitin ligase for PTEN.	ACACA ACACB	3.70e-04	29	34	2	21532586
Pubmed	Inceptor counteracts insulin signalling in β-cells to control glycaemia.	ACACA ACACB	5.10e-04	34	34	2	33505018
Pubmed	LKB1 deletion causes early changes in atrial channel expression and electrophysiology prior to atrial fibrillation.	ACACA ACACB	5.10e-04	34	34	2	26378152
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	SIN3B TBC1D15 ACACA ACACB	7.17e-04	418	34	4	34709266
Pubmed	A Multipronged Unbiased Strategy Guides the Development of an Anti-EGFR/EPHA2-Bispecific Antibody for Combination Cancer Therapy.	PHLDB3 ACACA ACACB XPR1	7.36e-04	421	34	4	36976175
Pubmed	Proteomic analysis of HIV-1 Gag interacting partners using proximity-dependent biotinylation.	ACACA ACACB	7.79e-04	42	34	2	26362536
Pubmed	Functional dissection of Rab GTPases involved in primary cilium formation.	TBC1D15 TBC1D5	8.17e-04	43	34	2	17646400
Pubmed	Congenital Disorders of N-Linked Glycosylation and Multiple Pathway Overview	ALG11 SRD5A3	8.55e-04	44	34	2	20301507
Pubmed	Developmental waves of mechanosensitivity acquisition in sensory neuron subtypes during embryonic development.	TRPM4 ASIC1	8.55e-04	44	34	2	19322198
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	ACACA ACACB ANO3 INPP5B XPR1	8.93e-04	777	34	5	35844135
Interaction	SGCB interactions	SLC22A9 SGCZ CD1B PLTP	1.20e-05	87	33	4	int:SGCB
Interaction	PTPRN interactions	ALG11 TBC1D15 TTYH3 GRAMD1A	3.88e-05	117	33	4	int:PTPRN
Cytoband	20q13.12	PLTP PCIF1	9.17e-04	60	34	2	20q13.12
Cytoband	19p13.11	SIN3B TMEM221	1.35e-03	73	34	2	19p13.11
Cytoband	Ensembl 112 genes in cytogenetic band chr19q13	PHLDB3 TRPM4 C5AR1 KIR3DL2 GRAMD1A	1.74e-03	1192	34	5	chr19q13
Cytoband	Ensembl 112 genes in cytogenetic band chr19p13	SIN3B TMEM221 DUS3L ATG4D	2.76e-03	797	34	4	chr19p13
GeneFamily	Phosphoinositide phosphatases	INPP5E INPP5B	6.86e-04	32	22	2	1079
GeneFamily	ADAM metallopeptidase domain containing\|CD molecules	CD1B C5AR1 KIR3DL2	1.16e-02	394	22	3	471
ToppCell	5'-Adult-LargeIntestine-Hematopoietic-Myeloid-Macrophages\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CD1B TTYH3 C5AR1 PLTP	1.49e-05	197	34	4	e698a0bbb20bd4868ff4348f2ac9f609942b55fa
ToppCell	Frontal_cortex-Endothelial-ENDOTHELIAL_TIP-Dcn_2-Dcn_2_2-Endothelial_Tip.Dcn.Dapl1_(Dapl1)\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	PHLDB3 MPZ TMEM221	7.21e-05	106	34	3	7079111add27d7b3411dfe739280d62dc256a174
ToppCell	Frontal_cortex-Endothelial-ENDOTHELIAL_TIP-Dcn_2-Dcn_2_2-Endothelial_Tip.Dcn.Dapl1_(Dapl1)-\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	PHLDB3 MPZ TMEM221	7.21e-05	106	34	3	a6334b67be05f78145b57271b7959471b80bd67f
ToppCell	BAL-Severe-cDC_4\|Severe / Compartment, Disease Groups and Clusters	ACACB INPP5E TBC1D5	2.35e-04	158	34	3	73f66689ef59f71b14cb7141ca5951cc47fe57c1
ToppCell	facs-Pancreas-Exocrine-18m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PHLDB3 SGCZ TBC1D25	2.57e-04	163	34	3	132aece9c79499b4bb3c2bde68d3d7202e1d8772
ToppCell	wk_15-18-Mesenchymal-Myofibro_&_SMC-Myofibro_3\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	TMEM221 ASIC1 ANO3	2.62e-04	164	34	3	583dda853cee9491dbdcb228c23d8deadc20eb08
ToppCell	droplet-Liver-HEPATOCYTES-1m-Epithelial-Hepatocyte_(Pericentral_and_Periportal)\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACACA ACACB SEC14L2	2.67e-04	165	34	3	d449a568664a81d9b5538e8f409301448a32ac37
ToppCell	390C-Myeloid-Macrophage-M2-like_Macrophage_(MARCO_negative)\|390C / Donor, Lineage, Cell class and subclass (all cells)	TTYH3 C5AR1 PLTP	2.86e-04	169	34	3	2c851b2703c7b8b656026f996f5fc027e4a79b36
ToppCell	droplet-Lung-nan-21m-Myeloid-basophil\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TRPM4 C5AR1 INPP5B	3.01e-04	172	34	3	b3c53fd7e50f36de6a8585ae21d04e17932f262c
ToppCell	droplet-Lung-nan-21m-Myeloid-Basophil\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TRPM4 C5AR1 INPP5B	3.01e-04	172	34	3	1b133be191252e7053faeacf9547730c3ae28d21
ToppCell	droplet-Lung-immune-endo-depleted-3m-Myeloid-basophil\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PHLDB3 TRPM4 C5AR1	3.06e-04	173	34	3	3612772632ddf11eb48579cae9a8ccab6b3f1f52
ToppCell	droplet-Lung-immune-endo-depleted-3m-Myeloid-Basophil\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PHLDB3 TRPM4 C5AR1	3.06e-04	173	34	3	4dc261ebcdb9bdcfca1451da1bd254f0dc5de203
ToppCell	Control-Myeloid-MoAM2,_CCL18\|Control / Condition, Lineage and Cell class	ARHGEF40 TTYH3 PLTP	3.11e-04	174	34	3	4c64ff5666812fb4efa440ba4faeca51d916d68e
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-Mono-Mono_anti-infl-B\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	TTYH3 C5AR1 PLTP	3.27e-04	177	34	3	382f0d6bbff01e84b0c7840e74ac865864e6da89
ToppCell	Control-Myeloid-MoAM2,_CCL18\|Myeloid / Condition, Lineage and Cell class	ARHGEF40 TTYH3 PLTP	3.27e-04	177	34	3	470f54fe2b21c7350ea471e02039461a3808f700
ToppCell	10x3'2.3-week_14-16-Myeloid_macrophage-stroma-monocytoid_macrophage\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	TTYH3 C5AR1 PLTP	3.33e-04	178	34	3	e44b0aa82890ae84fc4d1343f1c65ae2fda69a11
ToppCell	metastatic_Lymph_Node-Myeloid_cells-CD207+CD1a+_LCs\|metastatic_Lymph_Node / Location, Cell class and cell subclass	TRPM4 CD1B ASIC1	3.44e-04	180	34	3	289f8c4b53ffd164fee1f459a9315c0deb5f76d0
ToppCell	PBMC-Convalescent-Myeloid-Classical_Monocyte-Classical_Monocyte-cMono_4\|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	ARHGEF40 TTYH3 C5AR1	3.50e-04	181	34	3	2b9b460239d67fd480cee60820cdb306109d3567
ToppCell	PBMC-Convalescent-Myeloid-Classical_Monocyte-Classical_Monocyte-cMono_4\|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	ARHGEF40 TTYH3 C5AR1	3.50e-04	181	34	3	2a1aa4a0ec7bc367857beaff543135e4345c835b
ToppCell	5'-Adult-Appendix-Hematopoietic-Myeloid-Macrophages\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CD1B C5AR1 PLTP	3.55e-04	182	34	3	ea39b1b5db185b0cb11dfa2e01f3f972effbd770
ToppCell	TCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma-Acinar_Adenocarcinoma-7\|TCGA-Prostate / Sample_Type by Project: Shred V9	ACACA ATG4D GRAMD1A	3.55e-04	182	34	3	af16334fec2c757b03c84cf252d00e92fa81e4cd
ToppCell	3'-Broncho-tracheal-Immune_Myeloid-Myeloid_macrophage-elicited_macrophage-Monocyte-derived_macrophage-Monocyte-derived_macrophage_L.1.2.5.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TTYH3 C5AR1 PLTP	3.67e-04	184	34	3	d1ea2b60fb1ca1a0b809d131310c43903a9e84ce
ToppCell	TCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma-Acinar_Adenocarcinoma\|TCGA-Prostate / Sample_Type by Project: Shred V9	PHLDB3 TRPM4 GRAMD1A	3.73e-04	185	34	3	9d53e0a92e4f99370be2e4be1dd737630796b1ca
ToppCell	BAL-Control-Myeloid-MoAM-MoAM4\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	ARHGEF40 TTYH3 PLTP	3.73e-04	185	34	3	274b8acccdfe434d14af4cb32fb615c06ec98435
ToppCell	BAL-Control-Myeloid-MoAM-MoAM4\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	ARHGEF40 TTYH3 PLTP	3.73e-04	185	34	3	29d7ddcb9a2e45f76cd5611f7c52b6df689effd3
ToppCell	BAL-Control-Myeloid-MoAM-MoAM4-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	ARHGEF40 TTYH3 PLTP	3.73e-04	185	34	3	b640d9ed6a1e6aa595053065bb992efc0402353e
ToppCell	Adult-Immune-interstitial_macrophage_(C1Q_positive)-D175\|Adult / Lineage, Cell type, age group and donor	TTYH3 C5AR1 PLTP	3.73e-04	185	34	3	ab5704b96f1d368911308797d10c7c52766ab134
ToppCell	BAL-Control-Myeloid-MoAM-MoAM4-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	ARHGEF40 TTYH3 PLTP	3.73e-04	185	34	3	780bdb63ef913a09930063286011c9108381d3a9
ToppCell	TCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma\|TCGA-Prostate / Sample_Type by Project: Shred V9	PHLDB3 TRPM4 GRAMD1A	3.85e-04	187	34	3	fa0452f3382c22c0391b241d06504fda3c6a19f0
ToppCell	10x5'-bone_marrow-Myeloid_Mac\|bone_marrow / Manually curated celltypes from each tissue	TTYH3 C5AR1 PLTP	3.85e-04	187	34	3	99f39818b896032957fe123936d9e1877311c42e
ToppCell	3'-Adult-LargeIntestine-Hematopoietic-Myeloid-LYVE1+_Macrophage\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TTYH3 C5AR1 PLTP	3.85e-04	187	34	3	8e1d6d25db5b5c91a651bb2d66edfcf073a31704
ToppCell	TCGA-Prostate-Primary_Tumor\|TCGA-Prostate / Sample_Type by Project: Shred V9	PHLDB3 TRPM4 GRAMD1A	3.85e-04	187	34	3	3e6a95c912dad5d61e10497ffaafd2b9027cd13a
ToppCell	facs-Trachea-24m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l32-30\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	MPZ TBC1D25 ACACA	3.91e-04	188	34	3	c2febf9fd4632af1f922067c3a30e5c50f75f480
ToppCell	5'-GW_trimst-2-LargeIntestine-Hematopoietic-Myeloid-LYVE1+_Macrophage\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TTYH3 C5AR1 PLTP	3.91e-04	188	34	3	cb091912f9b627a78a8793a37df7f1de839f887f
ToppCell	normal_Lymph_Node-Myeloid_cells-mo-Mac\|normal_Lymph_Node / Location, Cell class and cell subclass	TTYH3 C5AR1 PLTP	3.91e-04	188	34	3	e83de94a9b47a6a90e98face887eae031a322af6
ToppCell	renal_medulla_nuclei-Adult_normal_reference\|renal_medulla_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group	ACACA ACACB TBC1D5	4.03e-04	190	34	3	f1363f7806cfc4f14fbc1b0e8dac2de813a88eee
ToppCell	Fetal_29-31_weeks-Immune-interstitial_macrophage_(C1Q_positive)-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	TTYH3 C5AR1 PLTP	4.09e-04	191	34	3	24d75b7e1d6fb9d24aa7844f584ee888a449841f
ToppCell	metastatic_Lymph_Node-Myeloid_cells-CD207+CD1a+_LCs\|Myeloid_cells / Location, Cell class and cell subclass	TRPM4 CD1B ASIC1	4.15e-04	192	34	3	f18da8db573e584c8b90df0814afcf020360108e
ToppCell	Control-Myeloid-MoAM4\|Control / Disease group,lineage and cell class （2021.01.30）	ARHGEF40 TTYH3 PLTP	4.15e-04	192	34	3	1da7c303a2e36af4a9d8ec30a11380d9b1897922
ToppCell	Adult-Immune-interstitial_macrophage_(C1Q_positive)\|Adult / Lineage, Cell type, age group and donor	TTYH3 C5AR1 PLTP	4.22e-04	193	34	3	31c0978ba78c9516d498aec0798902e57555e557
ToppCell	Immune-interstitial_macrophage_(C1Q_positive)\|World / Lineage, Cell type, age group and donor	TTYH3 C5AR1 PLTP	4.22e-04	193	34	3	64d598162a256ac6c9f8280c8a9133661dfbb10f
ToppCell	kidney_cells-Adult_normal_reference-Immune-Myeloid-Macrophage_Dendritic-M2_Macrophage\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TTYH3 C5AR1 PLTP	4.28e-04	194	34	3	abce1e824ce2512741c313a5ec336d12f580b093
ToppCell	367C-Myeloid-Macrophage-M2-like_Macrophage_(MARCO_negative)\|367C / Donor, Lineage, Cell class and subclass (all cells)	TTYH3 C5AR1 PLTP	4.28e-04	194	34	3	e3688f4252aae5f849f025d7f453ff4c0c14590b
ToppCell	kidney_cells-Adult_normal_reference-Immune-Myeloid-Macrophage_Dendritic\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TTYH3 C5AR1 PLTP	4.28e-04	194	34	3	6810586080cc893e3270b9c8bee2d95ed78e2893
ToppCell	Monocytes-C1QA+_Monocytes\|World / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues	TTYH3 C5AR1 PLTP	4.28e-04	194	34	3	3e104e85574894c04791252d466d438fc809dde3
ToppCell	systemic_lupus_erythematosus-flare-Lymphocytic-lymphocyte-male\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	TBC1D25 TBC1D15 KIR3DL2	4.28e-04	194	34	3	8f4b63b0b9a40765205e4ca6bd94a675a83dbe3d
ToppCell	3'-Pediatric_IBD-SmallIntestine-Hematopoietic-Myeloid-LYVE1+_Macrophage\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TTYH3 C5AR1 PLTP	4.35e-04	195	34	3	c16479a10f5ca2e89aea1742dbc5cc4dc9f3ea88
ToppCell	severe_COVID-19-Non-classical_Monocyte\|World / disease group, cell group and cell class (v2)	TTYH3 C5AR1 PLTP	4.35e-04	195	34	3	72928a1d987a3a5361c666f3972292aefec5f548
ToppCell	Monocytes-M2-like_CD16+_macrophages\|World / Immune cells in Kidney/Urine in Lupus Nephritis	ARHGEF40 C5AR1 PLTP	4.35e-04	195	34	3	10fa47bdcf6c9784ea930b75a5861e139421feed
ToppCell	medial-2-Hematologic-IGSF21+_Dendritic\|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	TTYH3 C5AR1 PLTP	4.35e-04	195	34	3	bb612979360b2322289545dda3d3c343d005ee6f
ToppCell	Fetal_29-31_weeks-Immune-interstitial_macrophage_(C1Q_positive)\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	TTYH3 C5AR1 PLTP	4.35e-04	195	34	3	312d9625655b38f1a7c2bf8f8bb7b667ebdf9617
ToppCell	medial-Hematologic-IGSF21+_Dendritic-2\|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	TTYH3 C5AR1 PLTP	4.35e-04	195	34	3	779130c2cfcbc603955b0c0332b855b22ab6e9e6
ToppCell	medial-Hematologic-IGSF21+_Dendritic\|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	TTYH3 C5AR1 PLTP	4.35e-04	195	34	3	330b688d703d53cb7feb29373b5a6e6e529169ec
ToppCell	10x3'2.3-week_14-16-Myeloid_macrophage-stroma\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	TTYH3 C5AR1 PLTP	4.41e-04	196	34	3	bd2c2de103e28b65ea537c22f71225cb0deef1e0
ToppCell	distal-Hematologic-EREG+_Dendritic-2\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	CD1B TTYH3 C5AR1	4.41e-04	196	34	3	c17bb7b3992bfec194bfa310f201a5c64b35868e
ToppCell	distal-Hematologic-EREG+_Dendritic\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	CD1B TTYH3 C5AR1	4.41e-04	196	34	3	14c6870d125fc2bdacf4199883399cec0dd3f569
ToppCell	10x3'2.3-week_14-16-Myeloid_macrophage\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	TTYH3 C5AR1 PLTP	4.41e-04	196	34	3	072a4150ae521c6589b0f7cd60e975fb33715bf4
ToppCell	normal_Lung-Myeloid_cells-mo-Mac\|normal_Lung / Location, Cell class and cell subclass	TTYH3 C5AR1 PLTP	4.41e-04	196	34	3	4d3a3264b3d781139899448cde3b7a4f214ca14d
ToppCell	mLN-T_cell-gd_T\|T_cell / Region, Cell class and subclass	KIR3DL2 PLTP EBLN2	4.41e-04	196	34	3	8f476408cd5a4ea9d25c763c66565343d7989b38
ToppCell	(3)_Macrophage_MARCOneg\|World / Lung cell shreds - cell class (v4) and cell subclass (v4)	TTYH3 C5AR1 PLTP	4.48e-04	197	34	3	b0ee2ce1179b60b4542559acb300a34295277dbc
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Myeloid-Macrophage-macrophage,_alveolar-Macro_c1-C1QC\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	TTYH3 C5AR1 PLTP	4.48e-04	197	34	3	1ded28732ea5d1f9ebca0b136575103540600ff1
ToppCell	5'-Adult-LargeIntestine-Hematopoietic-Myeloid-LYVE1+_Macrophage\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TTYH3 C5AR1 PLTP	4.48e-04	197	34	3	555ea43eccc3eb22be230c27e13d8b3b64c2a61f
ToppCell	COVID-19_Moderate-Classical_Monocyte\|COVID-19_Moderate / disease group, cell group and cell class	ARHGEF40 TTYH3 C5AR1	4.48e-04	197	34	3	98d4107e457e7399a84439acd73bf8f59598971b
ToppCell	3'-GW_trimst-2-LargeIntestine-Hematopoietic-Myeloid-LYVE1+_Macrophage\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TTYH3 C5AR1 PLTP	4.48e-04	197	34	3	b72dc02b76a782f08eb1350ce131b072caec1ab0
ToppCell	nucseq-Immune-Immune_Myeloid-IM\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	TTYH3 C5AR1 PLTP	4.48e-04	197	34	3	6f41c8f815851968849428ec92c16745bd01a3fb
ToppCell	mLN-T_cell-gd_T\|mLN / Region, Cell class and subclass	KIR3DL2 PLTP EBLN2	4.48e-04	197	34	3	8ef03bdbd34a874671aebfdbb7111106aa37b2a9
ToppCell	10x3'2.3-week_14-16-Myeloid_macrophage-stroma-stromal_macrophage\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	TTYH3 C5AR1 PLTP	4.48e-04	197	34	3	72775eb6c24cfb956436642ac9cd6e4d5c01ea5f
ToppCell	mLN-(1)_T_cell-(17)_gd_T\|mLN / shred on region, Cell_type, and subtype	KIR3DL2 PLTP EBLN2	4.48e-04	197	34	3	5c781ded147db2f3804ee1f21ef0898c4f354890
ToppCell	distal-2-Hematologic-EREG+_Dendritic\|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	CD1B TTYH3 C5AR1	4.48e-04	197	34	3	6fcca7c071e35786b715adeb18be317d34315d7e
ToppCell	nucseq-Immune-Immune_Myeloid-IM-IM\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	TTYH3 C5AR1 PLTP	4.48e-04	197	34	3	304044ace926943b8eb588f686ecbe5d1689a809
ToppCell	Bronchial-NucSeq-Immune_Myeloid-Macrophage_other-Macrophage_intravascular\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	TTYH3 C5AR1 PLTP	4.54e-04	198	34	3	c7dbf24caae5c4ef285845d13055de9e07281bb3
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Myeloid-Macrophage-macrophage,_alveolar-Macro_c1-C1QC\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	TTYH3 C5AR1 PLTP	4.54e-04	198	34	3	579a22199643440b98e381147779ced630d4ed66
ToppCell	Macrophages-IPF_03\|World / lung cells shred on cell class, cell subclass, sample id	TTYH3 C5AR1 PLTP	4.54e-04	198	34	3	8517386a2f0d14c7d5fc6283e4e16b94d7c5732a
ToppCell	5'-GW_trimst-2-SmallIntestine-Hematopoietic-Myeloid-LYVE1+_Macrophage\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TTYH3 C5AR1 PLTP	4.54e-04	198	34	3	acb84681569651447d684aa3960f0510d7ff17e8
ToppCell	PBMC-Mild-Myeloid-Classical_Monocyte-Classical_Monocyte-cMono_4\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	ARHGEF40 TTYH3 C5AR1	4.54e-04	198	34	3	06201b34d3e38f22c93b759511f7b376504bac06
ToppCell	distal-2-Hematologic-IGSF21+_Dendritic\|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	TTYH3 C5AR1 PLTP	4.54e-04	198	34	3	bcb62e466fc9b9b58cef30a87b98101d19a82ed4
ToppCell	distal-Hematologic-IGSF21+_Dendritic-2\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	TTYH3 C5AR1 PLTP	4.54e-04	198	34	3	323b4e6c31e18227546bb30566c1d872fda45e36
ToppCell	Smart-seq2-tissue-resident_(Smart-seq2)-myeloid-myeloid_macrophage-macrophage\|tissue-resident_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	TTYH3 C5AR1 PLTP	4.54e-04	198	34	3	76db943db8b5483754f38e4c6af7f5955cec420c
ToppCell	PBMC-Mild-Myeloid-Classical_Monocyte-Classical_Monocyte-cMono_4\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	ARHGEF40 TTYH3 C5AR1	4.54e-04	198	34	3	1ca91559fef231896e16180f5e050155c38f7cfa
ToppCell	ILEUM-inflamed-(3)_MNP-(3)_Resident_macrophages\|(3)_MNP / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	TTYH3 C5AR1 PLTP	4.54e-04	198	34	3	30bf78d4d657cf5140549d3dbf43d4f00482e300
ToppCell	Smart-seq2-thymus_(Smart-seq2)-myeloid\|thymus_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	TTYH3 C5AR1 PLTP	4.54e-04	198	34	3	2e470249edc7cf85bed550795ff84cbef22895c0
ToppCell	distal-1-Hematologic-EREG+_Dendritic\|1 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	TTYH3 C5AR1 PLTP	4.61e-04	199	34	3	15249f2f48b1e99d9d062835fd4c705a159e4abb
ToppCell	Healthy_donor-Classical_Monocyte\|World / disease group, cell group and cell class (v2)	ARHGEF40 TTYH3 C5AR1	4.61e-04	199	34	3	45e9099a13becb1e235435ceaaffb92b82ce34ee
ToppCell	wk_20-22-Hematologic-Myeloid-SPP1+_Mac\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	TTYH3 C5AR1 PLTP	4.61e-04	199	34	3	7c19f1b1f4369edd035ca9cdcf4e653771fc4648
ToppCell	5'-Adult-LargeIntestine-Hematopoietic-Myeloid\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TTYH3 C5AR1 PLTP	4.61e-04	199	34	3	a4785c1921a3de18a9190e4d674ede6a90f80004
ToppCell	10x_3'_v3-thymus_(10x_3'_v3)-myeloid-myeloid_macrophage-macrophage\|thymus_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	TTYH3 C5AR1 PLTP	4.61e-04	199	34	3	c0dcdda30485bb920d3706dcfb06f11b76b6ea37
ToppCell	tumor_Lung-Myeloid_cells-mo-Mac\|tumor_Lung / Location, Cell class and cell subclass	TTYH3 C5AR1 PLTP	4.61e-04	199	34	3	77d46acf655029eab23471dc4c4a1b0832b24306
ToppCell	10x_3'_v3-thymus_(10x_3'_v3)-myeloid-myeloid_macrophage\|thymus_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	TTYH3 C5AR1 PLTP	4.61e-04	199	34	3	b827dd8a249f904a0ff930a6c4d3b00fb7bc6fb1
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-Mono-Mono_anti-infl-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	TTYH3 C5AR1 PLTP	4.61e-04	199	34	3	667b8b47a5b388506e3177b46747267fad8024f6
ToppCell	5'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-lung_macrophage-Interstitial_macrophage_perivascular-Interstitial_macrophage_perivascular_L.1.2.1.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TTYH3 C5AR1 PLTP	4.61e-04	199	34	3	4e552015989defc32fe9068e0ba28521b2a1a09c
ToppCell	3'_v3-GI_small-bowel-Myeloid_Mac\|GI_small-bowel / Manually curated celltypes from each tissue	TTYH3 C5AR1 PLTP	4.61e-04	199	34	3	8990a3d69e24cb3aaba9d6def3d0be9ee973436d
ToppCell	3'_v3-GI_small-bowel-Myeloid_Mac-Intestinal_macrophages\|GI_small-bowel / Manually curated celltypes from each tissue	TTYH3 C5AR1 PLTP	4.61e-04	199	34	3	96070b5ffcbab4952970f43b536969ddd2ca5d14
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Myeloid-Macrophage-macrophage,_alveolar\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	TTYH3 C5AR1 PLTP	4.61e-04	199	34	3	697a9a58c0cdb77222700d029873355d37f6ab28
ToppCell	Smart-seq2-tissue-resident_(Smart-seq2)-myeloid-myeloid_macrophage\|tissue-resident_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	TTYH3 C5AR1 PLTP	4.61e-04	199	34	3	bcf7d15b6a08b24e7dd0ce106817659cb976f833
ToppCell	5'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-lung_macrophage-Interstitial_macrophage_perivascular\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TTYH3 C5AR1 PLTP	4.61e-04	199	34	3	0554f41ae53c275c92fe692bd999d7578d244fce
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Myeloid-Macrophage\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	TTYH3 C5AR1 PLTP	4.61e-04	199	34	3	c4fc638a8dad3a9b77634e8912a9326c8a2f11f5
ToppCell	Healthy/Control-Classical_Monocyte\|World / Disease group and Cell class	ARHGEF40 TTYH3 C5AR1	4.61e-04	199	34	3	527c767a09f911e319f7ad230b6518cebc0f367d
ToppCell	Parenchymal-10x5prime-Immune_Myeloid-Macrophage_other-Macro_CHIT1\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	TTYH3 C5AR1 PLTP	4.61e-04	199	34	3	f987f48970aec46156b80656e49b9f3604f3758c
ToppCell	5'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-lung_macrophage\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TTYH3 C5AR1 PLTP	4.61e-04	199	34	3	42d57522aa05892f37790d0039d936e065565359
ToppCell	cellseq-Immune-Immune_Myeloid-IM\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	TTYH3 C5AR1 PLTP	4.61e-04	199	34	3	b3267d5a7ae0461f5e9e6a3ab6783317a8c42506
Drug	Oxethazaine [126-27-2]; Up 200; 8.6uM; HL60; HG-U133A	MPZ C5AR1 ACACA ASIC1 INPP5E	9.95e-06	195	34	5	1984_UP
Drug	Cephalosporanic acid, 7-amino [957-68-6]; Up 200; 14.6uM; MCF7; HT_HG-U133A	ARHGEF40 ACACB ASIC1 PLTP PCIF1	1.07e-05	198	34	5	3258_UP
Drug	4,6,4'-trimethylangelicin	MPZ C5AR1	2.16e-05	5	34	2	CID000107731
Disease	level of phospholipid transfer protein in blood serum	PLTP PCIF1	1.29e-06	2	34	2	OBA_2042934
Disease	sarcoplasmic/endoplasmic reticulum calcium ATPase 3 measurement	PLTP PCIF1	3.86e-06	3	34	2	EFO_0802036
Disease	Fc receptor-like protein 5 measurement	PLTP PCIF1	3.86e-06	3	34	2	EFO_0802545
Disease	kit ligand measurement	PLTP PCIF1	3.86e-06	3	34	2	EFO_0010612
Disease	hemoglobin measurement, hemoglobin A2 measurement	PLTP PCIF1	1.29e-05	5	34	2	EFO_0004509, EFO_0005845
Disease	muscular disease (implicated_via_orthology)	ACACA ACACB	1.29e-05	5	34	2	DOID:0080000 (implicated_via_orthology)
Disease	coiled-coil domain-containing protein 126 measurement	PLTP PCIF1	2.70e-05	7	34	2	EFO_0801482
Disease	proactivator polypeptide-like 1 measurement	PLTP PCIF1	2.70e-05	7	34	2	EFO_0801912
Disease	f-box/LRR-repeat protein 4 measurement	PLTP PCIF1	5.77e-05	10	34	2	EFO_0802538
Disease	cholesteryl ester measurement, very low density lipoprotein cholesterol measurement	ACACB PLTP TBC1D5 PCIF1	1.28e-04	225	34	4	EFO_0008317, EFO_0010351
Disease	free cholesterol:total lipids ratio, intermediate density lipoprotein measurement	ACACB PLTP PCIF1	1.34e-04	86	34	3	EFO_0008595, EFO_0020945
Disease	triglycerides to total lipids in chylomicrons and extremely large VLDL percentage	PLTP PCIF1	1.34e-04	15	34	2	EFO_0022328
Disease	cholesterol to total lipids in chylomicrons and extremely large VLDL percentage	PLTP PCIF1	1.73e-04	17	34	2	EFO_0022232
Disease	esterified cholesterol measurement, high density lipoprotein cholesterol measurement	PLTP PCIF1	2.18e-04	19	34	2	EFO_0004612, EFO_0008589
Disease	sexual dimorphism measurement	ARHGEF40 ASIC1 INPP5E PLTP INPP5B FER1L4 PCIF1	2.26e-04	1106	34	7	EFO_0021796
Disease	free cholesterol to total lipids in chylomicrons and extremely large VLDL percentage	PLTP PCIF1	2.67e-04	21	34	2	EFO_0022277
Disease	cholesteryl esters to total lipids in chylomicrons and extremely large VLDL percentage	PLTP PCIF1	2.67e-04	21	34	2	EFO_0022246
Disease	cholesteryl ester measurement, chylomicron measurement, very low density lipoprotein cholesterol measurement	ACACB PLTP PCIF1	2.77e-04	110	34	3	EFO_0008317, EFO_0008596, EFO_0010351
Disease	chylomicron measurement, total cholesterol measurement, very low density lipoprotein cholesterol measurement	ACACB PLTP PCIF1	2.77e-04	110	34	3	EFO_0004574, EFO_0008317, EFO_0008596
Disease	pneumonia, COVID-19	ACACA ANO3 TBC1D5	3.00e-04	113	34	3	EFO_0003106, MONDO_0100096
Disease	ICAM-1 measurement	SGCZ ATG4D	3.50e-04	24	34	2	EFO_0004520
Disease	metabolite measurement	SLC22A9 SGCZ PLTP SEC14L2 PCIF1	4.27e-04	560	34	5	EFO_0004725
Disease	cholesterol to total lipids in medium LDL percentage	PLTP PCIF1	4.44e-04	27	34	2	EFO_0022238
Disease	cholesterol to total lipids in very large HDL percentage	PLTP PCIF1	5.87e-04	31	34	2	EFO_0022243
Disease	fatty liver disease (implicated_via_orthology)	ACACA ACACB	5.87e-04	31	34	2	DOID:9452 (implicated_via_orthology)
Disease	triglyceride measurement, phospholipid measurement	ACACB PLTP PCIF1	6.35e-04	146	34	3	EFO_0004530, EFO_0004639
Disease	chylomicron measurement, very low density lipoprotein cholesterol measurement, cholesteryl esters:total lipids ratio	PLTP PCIF1	7.06e-04	34	34	2	EFO_0008317, EFO_0008596, EFO_0020944
Disease	chylomicron measurement, triglycerides:total lipids ratio, very low density lipoprotein cholesterol measurement	PLTP PCIF1	7.06e-04	34	34	2	EFO_0008317, EFO_0008596, EFO_0020947
Disease	C-reactive protein measurement, high density lipoprotein cholesterol measurement	PLTP PCIF1	7.06e-04	34	34	2	EFO_0004458, EFO_0004612
Disease	obsolete_red blood cell distribution width	FBXO7 ALG11 INPP5E PLTP INPP5B TBC1D5 PCIF1	7.40e-04	1347	34	7	EFO_0005192
Disease	free cholesterol in small HDL measurement	PLTP PCIF1	7.49e-04	35	34	2	EFO_0022270
Disease	total lipids in small HDL measurement	PLTP PCIF1	7.49e-04	35	34	2	EFO_0022311
Disease	cholesterol in small HDL measurement	PLTP PCIF1	7.92e-04	36	34	2	EFO_0022226
Disease	cholesteryl esters to total lipids in very large HDL percentage	PLTP PCIF1	7.92e-04	36	34	2	EFO_0022257
Disease	phospholipids in small HDL measurement	PLTP PCIF1	8.83e-04	38	34	2	EFO_0022296
Disease	Congenital disorder of glycosylation	ALG11 SRD5A3	8.83e-04	38	34	2	cv:C0282577
Disease	apolipoprotein B measurement	ACACB ATG4D PLTP FER1L4 PCIF1	9.15e-04	663	34	5	EFO_0004615
Disease	triglyceride measurement, low density lipoprotein cholesterol measurement	ACACB PLTP PCIF1	9.20e-04	166	34	3	EFO_0004530, EFO_0004611
Disease	triglycerides to total lipids in large VLDL percentage	PLTP PCIF1	9.30e-04	39	34	2	EFO_0022332
Disease	degree of unsaturation measurement	PLTP PCIF1	9.30e-04	39	34	2	EFO_0022261
Disease	cholesterol in very small VLDL measurement	PLTP PCIF1	9.78e-04	40	34	2	EFO_0022231
Disease	chylomicron measurement, very low density lipoprotein cholesterol measurement, free cholesterol:total lipids ratio	PLTP PCIF1	1.08e-03	42	34	2	EFO_0008317, EFO_0008596, EFO_0020945
Disease	free cholesterol to total lipids in IDL percentage	PLTP PCIF1	1.13e-03	43	34	2	EFO_0022278
Disease	free cholesterol to total lipids in very small VLDL percentage	PLTP PCIF1	1.13e-03	43	34	2	EFO_0022290

Protein segments in the cluster

Peptide	Gene	Start	Entry
RSWCLCKLLRFFYSL	ALG11	6	Q2TAA5
CFELWFRRRRAREAY	ARHGEF40	1336	Q8TER5
SRTFFYWRLRRLLLE	ACACA	2211	Q13085
TRRFLLEWLSFLCRY	DUS3L	571	Q96G46
CYTFILLRTWSRRAT	C5AR1	221	P21730
LLCLALWYMRRRSYQ	CD1B	316	P29016
FGARDRCFLLIFRLW	GRAMD1A	181	Q96CP6
FLEFWKRRRSILTYT	ANO3	486	Q9BYT9
LFILLLFFLLYRWCS	KIR3DL2	351	P43630
TARTFLYWRLRRLLL	ACACB	2321	O00763
KRWFCFDRQARRLAY	PHLDB3	551	Q6NSJ2
LYMSLFIRRDLIWFC	INPP5E	371	Q9NRR6
FFIWRRYWRTLVLLL	FER1L4	1751	A9Z1Z3
SLGLRFRRQLLYWFF	PLTP	96	P55058
LFVWVCDRSYKRSFR	EBLN2	16	Q6P2I7
LWLHSLRRLFECLYV	SRD5A3	136	Q9H8P0
FERFLPRVWCLLRRY	PCIF1	461	Q9H4Z3
LWRFLYLRDFRDNTV	FBXO7	371	Q9Y3I1
FLWLSRYRCAELELE	INPP5B	141	P32019
YFLLRWLRARSFDLQ	SEC14L2	36	O76054
RFLCWSRERLTYFLE	BVES	226	Q8NE79
FYRCAVLLRWRLLHT	MROH5	1191	Q6ZUA9
CYRWLLLELKREFAF	TBC1D25	406	Q3MII6
LSDRFGRRFVLRWCY	SLC22A9	166	Q8IVM8
WYFFLRLHQTLCSRL	SIN3B	781	O75182
WRKRCLYFFVLLLLV	SGCZ	31	Q96LD1
YERLSLKRALWALCF	ASIC1	36	P78348
RFQRDFVSRLWLTYR	ATG4D	111	Q86TL0
AWLRFIQCLRRYRDT	XPR1	456	Q9UBH6
YFCFRWLLIRFKREF	TBC1D15	526	Q8TC07
RRSDWFLYDCRLLRH	TMEM221	106	A6NGB7
LRSSRFRSICWKLFL	TBC1D5	81	Q92609
LLFYSFWLCCRRRKS	TTYH3	61	Q9C0H2
LLYFWAFTLLCEELR	TRPM4	816	Q8TD43
LLLLLFYVVRYCWLR	MPZ	171	P25189