Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	heparin binding	SLIT2 THBS2 THBS3 THBS4 REG4 COMP	1.15e-05	192	53	6	GO:0008201
GeneOntologyMolecularFunction	sulfur compound binding	SLIT2 THBS2 THBS3 THBS4 REG4 COMP RYR2	2.21e-05	323	53	7	GO:1901681
GeneOntologyMolecularFunction	calcium ion binding	SLIT2 DUOX1 THBS2 THBS3 THBS4 DST REG4 COMP SUSD1 RYR2	2.35e-05	749	53	10	GO:0005509
GeneOntologyMolecularFunction	glycosaminoglycan binding	SLIT2 THBS2 THBS3 THBS4 REG4 COMP	7.48e-05	268	53	6	GO:0005539
GeneOntologyMolecularFunction	extracellular matrix structural constituent	SLIT2 THBS2 THBS3 THBS4 COMP	1.40e-04	188	53	5	GO:0005201
GeneOntologyMolecularFunction	laminin-1 binding	SLIT2 THBS4	1.92e-04	8	53	2	GO:0043237
GeneOntologyMolecularFunction	non-membrane spanning protein tyrosine phosphatase activity	PTPN9 PTPN12	4.49e-04	12	53	2	GO:0004726
GeneOntologyBiologicalProcess	epithelial cell-cell adhesion	THBS4 DSP KIT	1.13e-05	18	51	3	GO:0090136
MousePheno	abnormal response to injury	FAH THBS2 THBS4 DST COMP DSP GLP1R INPP5F PRMT7 KIT RYR2	1.53e-06	607	43	11	MP:0005164
MousePheno	increased response of heart to induced stress	THBS4 DSP INPP5F RYR2	2.04e-05	53	43	4	MP:0004485
MousePheno	duplex kidney	SLIT2 CC2D2A DNAH11	2.54e-05	19	43	3	MP:0004017
MousePheno	biventricular, discordant atrioventricular connection	CC2D2A DNAH11	2.77e-05	3	43	2	MP:0011510
MousePheno	increased susceptibility to injury	FAH THBS4 DSP INPP5F KIT RYR2	3.89e-05	208	43	6	MP:0005165
MousePheno	abnormal blood vessel morphology	PCSK1 MED24 FAH SLIT2 THBS2 FBXW8 THBS4 PTPN12 DST RRM2B PRMT7 KIT CREBBP DNAH11	7.98e-05	1472	43	14	MP:0001614
MousePheno	cardiac fibrosis	THBS4 DSP RRM2B INPP5F RYR2	9.52e-05	151	43	5	MP:0003141
MousePheno	absent endocochlear potential	KCNJ10 KIT	1.92e-04	7	43	2	MP:0004410
MousePheno	superior-inferior ventricles	CC2D2A DNAH11	1.92e-04	7	43	2	MP:0011254
MousePheno	decreased vascular endothelial cell number	PTPN12 CREBBP	2.56e-04	8	43	2	MP:0006057
Domain	TSP_3	THBS2 THBS3 THBS4 COMP	2.67e-10	5	52	4	PF02412
Domain	TSP3	THBS2 THBS3 THBS4 COMP	2.67e-10	5	52	4	PS51234
Domain	TSP_CTER	THBS2 THBS3 THBS4 COMP	2.67e-10	5	52	4	PS51236
Domain	-	THBS2 THBS3 THBS4 COMP	2.67e-10	5	52	4	4.10.1080.10
Domain	Thrombospondin_C	THBS2 THBS3 THBS4 COMP	2.67e-10	5	52	4	IPR008859
Domain	TSP_C	THBS2 THBS3 THBS4 COMP	2.67e-10	5	52	4	PF05735
Domain	Thrombospondin_3_rpt	THBS2 THBS3 THBS4 COMP	2.67e-10	5	52	4	IPR017897
Domain	Thrombospondin_3-like_rpt	THBS2 THBS3 THBS4 COMP	2.67e-10	5	52	4	IPR003367
Domain	TSP_type-3_rpt	THBS2 THBS3 THBS4 COMP	2.67e-10	5	52	4	IPR028974
Domain	Thbs/COMP_coiled-coil	THBS3 THBS4 COMP	2.04e-08	3	52	3	IPR024665
Domain	COMP	THBS3 THBS4 COMP	2.04e-08	3	52	3	PF11598
Domain	-	SLIT2 THBS2 THBS3 THBS4 COMP CNTNAP4	2.49e-07	95	52	6	2.60.120.200
Domain	Laminin_G	SLIT2 THBS2 THBS3 THBS4 CNTNAP4	5.63e-07	58	52	5	IPR001791
Domain	EGF_CA	SLIT2 THBS2 THBS3 THBS4 COMP SUSD1	1.09e-06	122	52	6	SM00179
Domain	EGF-like_Ca-bd_dom	SLIT2 THBS2 THBS3 THBS4 COMP SUSD1	1.20e-06	124	52	6	IPR001881
Domain	ConA-like_dom	SLIT2 THBS2 THBS3 THBS4 COMP CNTNAP4 RYR2	2.37e-06	219	52	7	IPR013320
Domain	EGF_3	SLIT2 THBS2 THBS3 THBS4 COMP SUSD1 CNTNAP4	3.77e-06	235	52	7	PS50026
Domain	EGF	SLIT2 THBS2 THBS3 THBS4 COMP SUSD1 CNTNAP4	3.77e-06	235	52	7	SM00181
Domain	EGF_CA	THBS2 THBS3 THBS4 COMP SUSD1	4.03e-06	86	52	5	PF07645
Domain	EGF-like_dom	SLIT2 THBS2 THBS3 THBS4 COMP SUSD1 CNTNAP4	5.52e-06	249	52	7	IPR000742
Domain	EGF_1	SLIT2 THBS2 THBS3 THBS4 COMP SUSD1 CNTNAP4	6.45e-06	255	52	7	PS00022
Domain	EGF_Ca-bd_CS	SLIT2 THBS3 THBS4 COMP SUSD1	7.30e-06	97	52	5	IPR018097
Domain	EGF-like_CS	SLIT2 THBS2 THBS3 THBS4 COMP SUSD1 CNTNAP4	7.51e-06	261	52	7	IPR013032
Domain	EGF_CA	SLIT2 THBS3 THBS4 COMP SUSD1	8.06e-06	99	52	5	PS01187
Domain	EGF_2	SLIT2 THBS2 THBS3 THBS4 COMP SUSD1 CNTNAP4	8.30e-06	265	52	7	PS01186
Domain	TSPN	THBS2 THBS3 THBS4	3.47e-05	23	52	3	SM00210
Domain	-	DST DSP	1.13e-04	6	52	2	3.90.1290.10
Domain	Plectin_repeat	DST DSP	1.58e-04	7	52	2	IPR001101
Domain	Plectin	DST DSP	1.58e-04	7	52	2	PF00681
Domain	PLEC	DST DSP	1.58e-04	7	52	2	SM00250
Domain	EGF	SLIT2 THBS2 THBS4 CNTNAP4	4.16e-04	126	52	4	PF00008
Domain	ATPase_dyneun-rel_AAA	MDN1 DNAH11	6.77e-04	14	52	2	IPR011704
Domain	AAA_5	MDN1 DNAH11	6.77e-04	14	52	2	PF07728
Domain	Growth_fac_rcpt_	THBS3 THBS4 COMP SUSD1	9.28e-04	156	52	4	IPR009030
Domain	TAS2R	TAS2R45 TAS2R46	2.37e-03	26	52	2	PF05296
Domain	T2R	TAS2R45 TAS2R46	2.37e-03	26	52	2	IPR007960
Domain	Spectrin_repeat	DST DSP	2.94e-03	29	52	2	IPR002017
Domain	Spectrin/alpha-actinin	DST DSP	3.57e-03	32	52	2	IPR018159
Domain	SPEC	DST DSP	3.57e-03	32	52	2	SM00150
Domain	PTPc	PTPN9 PTPN12	4.51e-03	36	52	2	SM00194
Domain	LAM_G_DOMAIN	SLIT2 CNTNAP4	5.01e-03	38	52	2	PS50025
Domain	TYR_PHOSPHATASE_PTP	PTPN9 PTPN12	5.27e-03	39	52	2	PS50055
Domain	Laminin_G_2	SLIT2 CNTNAP4	5.54e-03	40	52	2	PF02210
Pathway	KEGG_TGF_BETA_SIGNALING_PATHWAY	THBS2 THBS3 THBS4 COMP CREBBP	7.58e-06	86	45	5	M2642
Pathway	REACTOME_SIGNALING_BY_PDGF	THBS2 THBS3 THBS4 PTPN12	3.16e-05	57	45	4	MM14713
Pathway	REACTOME_SIGNALING_BY_PDGF	THBS2 THBS3 THBS4 PTPN12	3.39e-05	58	45	4	M2049
Pathway	KEGG_ECM_RECEPTOR_INTERACTION	THBS2 THBS3 THBS4 COMP	1.45e-04	84	45	4	M7098
Pathway	WP_GLP1_FROM_INTESTINE_AND_PANCREAS_AND_ROLE_IN_GLUCOSE_HOMEOSTASIS	PCSK1 GLP1R	1.48e-04	6	45	2	M48303
Pubmed	Thrombospondin-3 augments injury-induced cardiomyopathy by intracellular integrin inhibition and sarcolemmal instability.	THBS2 THBS3 THBS4 COMP	2.40e-11	5	53	4	30622267
Pubmed	Thrombospondins 1 and 2 are important for afferent synapse formation and function in the inner ear.	THBS2 THBS3 THBS4 COMP	3.35e-10	8	53	4	24460873
Pubmed	Pathological Significance and Prognostic Roles of Thrombospondin-3, 4 and 5 in Bladder Cancer.	THBS3 THBS4 COMP	3.34e-09	3	53	3	33910854
Pubmed	Immunohistochemical localisation of thrombospondin in human megakaryocytes and platelets.	THBS2 THBS3 THBS4	1.34e-08	4	53	3	6338048
Pubmed	Skeletal abnormalities in mice lacking extracellular matrix proteins, thrombospondin-1, thrombospondin-3, thrombospondin-5, and type IX collagen.	THBS3 THBS4 COMP	3.33e-08	5	53	3	18467703
Pubmed	GLP-1 receptor signaling increases PCSK1 and β cell features in human α cells.	PCSK1 GLP1R	2.28e-06	2	53	2	33554958
Pubmed	Biophysical characterization of the signature domains of thrombospondin-4 and thrombospondin-2.	THBS2 THBS4	2.28e-06	2	53	2	16246837
Pubmed	Overnight transduction with foamyviral vectors restores the long-term repopulating activity of Fancc-/- stem cells.	FANCC KIT	2.28e-06	2	53	2	18684868
Pubmed	Corneal stromal cells (keratocytes) express thrombospondins 2 and 3 in wound repair phenotype.	THBS2 THBS3	2.28e-06	2	53	2	11943589
Pubmed	Associations of THBS2 and THBS4 polymorphisms to gastric cancer in a Southeast Chinese population.	THBS2 THBS4	2.28e-06	2	53	2	27160021
Pubmed	Cultured human retinal pigment epithelial cells differentially express thrombospondin-1, -2, -3, and -4.	THBS3 THBS4	2.28e-06	2	53	2	11137453
Pubmed	Relative abundance of thrombospondin 2 and thrombospondin 3 mRNAs in human tissues.	THBS2 THBS3	2.28e-06	2	53	2	10329465
Pubmed	Variants within the COMP and THBS2 genes are not associated with Achilles tendinopathy in a case-control study of South African and Australian populations.	THBS2 COMP	2.28e-06	2	53	2	23875975
Pubmed	COMP and TSP-4 interact specifically with the novel GXKGHR motif only found in fibrillar collagens.	THBS4 COMP	2.28e-06	2	53	2	30464261
Pubmed	Increased cortical expression of two synaptogenic thrombospondins in human brain evolution.	THBS2 THBS4	2.28e-06	2	53	2	17182969
Pubmed	Expression and function of thrombospondin-1 in myelinating glial cells of the central nervous system.	THBS2 THBS3	6.83e-06	3	53	2	9373030
Pubmed	Large scale association analysis for identification of genes underlying premature coronary heart disease: cumulative perspective from analysis of 111 candidate genes.	THBS2 THBS4	6.83e-06	3	53	2	15121769
Pubmed	Thrombospondin-2 polymorphism is associated with a reduced risk of premature myocardial infarction.	THBS2 THBS4	6.83e-06	3	53	2	12482844
Pubmed	Thrombospondin-1, -2 and -5 have differential effects on vascular smooth muscle cell physiology.	THBS2 COMP	6.83e-06	3	53	2	26168731
Pubmed	Association between single nucleotide polymorphisms in thrombospondins genes and coronary artery disease: A meta-analysis.	THBS2 THBS4	6.83e-06	3	53	2	25976449
Pubmed	mRNA Expression of thrombospondin 1, 2 and 3 from proximal to distal in human abdominal aortic aneurysm - preliminary report.	THBS2 THBS3	6.83e-06	3	53	2	34669362
Pubmed	Thrombospondin 1 and thrombospondin 2 are expressed as both homo- and heterotrimers.	THBS2 THBS3	6.83e-06	3	53	2	1459996
Pubmed	Polymorphisms in thrombospondin genes and myocardial infarction: a case-control study and a meta-analysis of available evidence.	THBS2 THBS4	6.83e-06	3	53	2	18178577
Pubmed	Differential expression of thrombospondin 1, 2, and 3 during murine development.	THBS2 THBS3	6.83e-06	3	53	2	8400410
Pubmed	An inhibitor of the acetyltransferases CBP/p300 exerts antineoplastic effects on gastrointestinal stromal tumor cells.	KIT CREBBP	1.36e-05	4	53	2	27633918
Pubmed	Cdc42 is required for male germline niche development in mice.	PLEKHA5 KIT	1.36e-05	4	53	2	34407418
Pubmed	Expression status of candidate genes in mesothelioma tissues and cell lines.	THBS2 DSP	1.36e-05	4	53	2	25771974
Pubmed	TBX1 is required for normal stria vascularis and semicircular canal development.	THBS4 COMP KCNJ10	1.46e-05	31	53	3	31550482
Pubmed	Synaptic hyperexcitability of cytomegalic pyramidal neurons contributes to epileptogenesis in tuberous sclerosis complex.	THBS2 THBS4 KCNJ10	2.11e-05	35	53	3	35858542
Pubmed	Cytogenetic characterization of radiosensitive mouse mutants.	DST KIT	2.27e-05	5	53	2	1720867
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	ACTR1A PTPN12 MDN1 DST MBOAT7 DSP NIPSNAP1 PLEKHA5 HUWE1 CREBBP	3.26e-05	1353	53	10	29467282
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	DST DSP PLEKHA5 HUWE1 INPP5F SPAG5	4.14e-05	418	53	6	34709266
Pubmed	Sertoli cells are the source of stem cell factor for spermatogenesis.	PLEKHA5 KIT	4.76e-05	7	53	2	36861441
Pubmed	Large-scale structural analysis of the classical human protein tyrosine phosphatome.	PTPN9 PTPN12 KIT	5.17e-05	47	53	3	19167335
Pubmed	Peptidyl arginine deiminase 2 (Padi2) is expressed in Sertoli cells in a specific manner and regulated by SOX9 during testicular development.	PLEKHA5 KIT	6.34e-05	8	53	2	30185873
Pubmed	K63-polyubiquitinated HAUSP deubiquitinates HIF-1α and dictates H3K56 acetylation promoting hypoxia-induced tumour progression.	HUWE1 CREBBP	6.34e-05	8	53	2	27934968
Pubmed	Association of common promoter polymorphisms of MCP1 with hepatitis B virus clearance.	THBS2 THBS4	6.34e-05	8	53	2	17202846
Pubmed	Microarray analysis on Runx2-deficient mouse embryos reveals novel Runx2 functions and target genes during intramembranous and endochondral bone formation.	SLIT2 COMP	6.34e-05	8	53	2	16774856
Pubmed	Analysis of the interactions between BP180, BP230, plectin and the integrin alpha6beta4 important for hemidesmosome assembly.	DST DSP	8.15e-05	9	53	2	12482924
Pubmed	Isolation of novel mouse genes that were differentially expressed in W/W(V) mouse fundus.	MBOAT7 KIT	1.02e-04	10	53	2	15065000
Pubmed	Arrhythmogenic Right Ventricular Cardiomyopathy Overview	DSP RYR2	1.02e-04	10	53	2	20301310
Pubmed	Interaction of the bullous pemphigoid antigen 1 (BP230) and desmoplakin with intermediate filaments is mediated by distinct sequences within their COOH terminus.	DST DSP	1.24e-04	11	53	2	12802069
Pubmed	Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study.	SLIT2 RYR2	1.24e-04	11	53	2	17903301
Pubmed	Cardiac disease and arrhythmogenesis: Mechanistic insights from mouse models.	DSP RYR2	1.24e-04	11	53	2	27766308
Pubmed	Genomic analysis of mouse retinal development.	FANCC MED24 SLIT2 PTPN12 DST PRMT7 KIT CCNK	1.33e-04	1006	53	8	15226823
Pubmed	Identification of a transcriptionally active peroxisome proliferator-activated receptor alpha -interacting cofactor complex in rat liver and characterization of PRIC285 as a coactivator.	MED24 CREBBP	1.49e-04	12	53	2	12189208
Pubmed	The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides.	TAS2R45 TAS2R46	1.49e-04	12	53	2	12379855
Pubmed	Transcriptomic analysis of mouse limb tendon cells during development.	THBS2 THBS4	1.49e-04	12	53	2	25249460
Pubmed	Retinoic Acid Receptors Control Spermatogonia Cell-Fate and Induce Expression of the SALL4A Transcription Factor.	PLEKHA5 KIT	1.49e-04	12	53	2	26427057
Pubmed	The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4.	TNRC18 DST NIPSNAP1 HUWE1 CREBBP	1.52e-04	332	53	5	37433992
Pubmed	Haplotypes at the Tas2r locus on distal chromosome 6 vary with quinine taste sensitivity in inbred mice.	TAS2R45 TAS2R46	1.76e-04	13	53	2	15938754
Pubmed	Identifying genes differentially expressed between PGCs and ES cells reveals a role for CREB-binding protein in germ cell survival.	KIT CREBBP	2.05e-04	14	53	2	17936260
Pubmed	Headbobber: a combined morphogenetic and cochleosaccular mouse model to study 10qter deletions in human deafness.	KCNJ10 KIT	2.05e-04	14	53	2	23457544
Pubmed	Subcellular localization of intracellular protein tyrosine phosphatases in T cells.	PTPN9 PTPN12	2.05e-04	14	53	2	10940933
Pubmed	Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis.	ACTR1A DUOX1 MDN1 DST DSP HUWE1 SPAG5	2.15e-04	807	53	7	30575818
Pubmed	Functional screening of FxxLF-like peptide motifs identifies SMARCD1/BAF60a as an androgen receptor cofactor that modulates TMPRSS2 expression.	MED24 MDN1	2.36e-04	15	53	2	19762545
Pubmed	Functional proteomics mapping of a human signaling pathway.	PTPN12 DST SUSD1 HUWE1 CREBBP RYR2	2.74e-04	591	53	6	15231748
Pubmed	Interactomes of Glycogen Synthase Kinase-3 Isoforms.	PTPN12 DST PLEKHA5 SPAG5	2.95e-04	209	53	4	36779422
Pubmed	Nell1-deficient mice have reduced expression of extracellular matrix proteins causing cranial and vertebral defects.	THBS2 THBS3 THBS4 COMP	3.00e-04	210	53	4	16537572
Pubmed	Protein tyrosine phosphatases expression during development of mouse superior colliculus.	PTPN9 PTPN12	3.05e-04	17	53	2	19727691
Pubmed	The CCND1 c.870G>A polymorphism is a risk factor for t(11;14)(q13;q32) multiple myeloma.	MED24 DNAH11	3.05e-04	17	53	2	23502783
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	TNRC18 MBOAT7 DSP NIPSNAP1 AKR7A3 AASDHPPT HUWE1 RYR2	3.09e-04	1139	53	8	36417873
Pubmed	Large-scale screen for genes involved in gonad development.	MED24 NIPSNAP1 PLEKHA5	3.13e-04	86	53	3	11044607
Pubmed	Morphogenetic competence of HNF4 alpha-deficient mouse hepatic cells.	FAH KIT	3.43e-04	18	53	2	18617288
Pubmed	An ARC/Mediator subunit required for SREBP control of cholesterol and lipid homeostasis.	MED24 CREBBP	3.83e-04	19	53	2	16799563
Pubmed	Acetylation of poly(ADP-ribose) polymerase-1 by p300/CREB-binding protein regulates coactivation of NF-kappaB-dependent transcription.	MED24 CREBBP	3.83e-04	19	53	2	16204234
Pubmed	TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.	PTPN9 MDN1 MBOAT7 CREBBP RYR2 DNAH11	4.11e-04	638	53	6	31182584
Pubmed	QKI is a critical pre-mRNA alternative splicing regulator of cardiac myofibrillogenesis and contractile function.	DST RYR2	4.25e-04	20	53	2	33397958
Pubmed	Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes.	MED24 ACTR1A DST HUWE1 CREBBP SPAG5	4.35e-04	645	53	6	25281560
Pubmed	USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.	SLIT2 MDN1 DST DSP	4.52e-04	234	53	4	36243803
Pubmed	A novel family of mammalian taste receptors.	TAS2R45 TAS2R46	4.70e-04	21	53	2	10761934
Pubmed	Polymorphisms in the platelet-specific collagen receptor GP6 are associated with risk of nonfatal myocardial infarction in Caucasians.	THBS2 THBS4	4.70e-04	21	53	2	20227257
Pubmed	Global genetic analysis in mice unveils central role for cilia in congenital heart disease.	SLIT2 CC2D2A DNAH11	4.87e-04	100	53	3	25807483
Pubmed	Evolutionary relationships of the Tas2r receptor gene families in mouse and human.	TAS2R45 TAS2R46	5.16e-04	22	53	2	12734386
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	PTPN12 DST DSP AASDHPPT PRMT7 CCNK SPAG5	5.18e-04	934	53	7	33916271
Pubmed	Composite co-activator ARC mediates chromatin-directed transcriptional activation.	MED24 CREBBP	5.65e-04	23	53	2	10235267
Pubmed	The molecular receptive ranges of human TAS2R bitter taste receptors.	TAS2R45 TAS2R46	5.65e-04	23	53	2	20022913
Pubmed	Reprogramming of Sertoli cells to fetal-like Leydig cells by Wt1 ablation.	THBS2 PLEKHA5	5.65e-04	23	53	2	25775596
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	ACTR1A PTPN9 MDN1 DST KCNJ10 PLEKHA5 HUWE1	6.20e-04	963	53	7	28671696
Pubmed	Cilia gene mutations cause atrioventricular septal defects by multiple mechanisms.	CC2D2A DNAH11	6.68e-04	25	53	2	27340223
Pubmed	Receptors for bitter and sweet taste.	TAS2R45 TAS2R46	6.68e-04	25	53	2	12139982
Pubmed	Molecular mechanisms of bitter and sweet taste transduction.	TAS2R45 TAS2R46	7.23e-04	26	53	2	11696554
Pubmed	Deletion of the tyrosine phosphatase Shp2 in Sertoli cells causes infertility in mice.	PLEKHA5 KIT	7.23e-04	26	53	2	26265072
Pubmed	Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner.	MED24 TNRC18 CREBBP CCNK	7.50e-04	268	53	4	33640491
Pubmed	A novel role for the peptidyl-prolyl cis-trans isomerase Cyclophilin A in DNA-repair following replication fork stalling via the MRE11-RAD50-NBS1 complex.	DST PLEKHA5 PRMT7 CCNK SPAG5	7.57e-04	472	53	5	38943005
Pubmed	Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways.	TAS2R45 TAS2R46	7.80e-04	27	53	2	12581520
Pubmed	Genetic link between renal birth defects and congenital heart disease.	SLIT2 CC2D2A	8.40e-04	28	53	2	27002738
Pubmed	Lineage-specific loss of function of bitter taste receptor genes in humans and nonhuman primates.	TAS2R45 TAS2R46	8.40e-04	28	53	2	15744053
Pubmed	Large-scale proteomics and phosphoproteomics of urinary exosomes.	FAH SLIT2 ACTR1A DSP AKR7A3 AASDHPPT HUWE1	8.50e-04	1016	53	7	19056867
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	SLIT2 FBXW8 MDN1 DST DSP NIPSNAP1 HUWE1	8.90e-04	1024	53	7	24711643
Pubmed	Prox2 and Runx3 vagal sensory neurons regulate esophageal motility.	GLP1R KIT	9.01e-04	29	53	2	37192624
Pubmed	BMP4-BMPR1A signaling in beta cells is required for and augments glucose-stimulated insulin secretion.	PCSK1 GLP1R	9.01e-04	29	53	2	17339028
Pubmed	Mapping of QTLs for oral alcohol self-administration in B6.C and B6.I quasi-congenic RQI strains.	TAS2R45 TAS2R46	9.64e-04	30	53	2	17273929
Pubmed	Adaptive diversification of bitter taste receptor genes in Mammalian evolution.	TAS2R45 TAS2R46	9.64e-04	30	53	2	12679530
Pubmed	VCP phosphorylation-dependent interaction partners prevent apoptosis in Helicobacter pylori-infected gastric epithelial cells.	PTPN9 MDN1 DSP HUWE1	9.80e-04	288	53	4	23383273
Pubmed	HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis.	MED24 PLB1 THBS4 DSP AASDHPPT CREBBP	9.83e-04	754	53	6	35906200
Pubmed	Large-scale analysis of ion channel gene expression in the mouse heart during perinatal development.	KCNJ10 KCNMB4 RYR2	1.26e-03	139	53	3	16985003
Pubmed	[IMAGE: molecular integration of the analysis of the human genome and its expression].	CNTNAP4 MRPL35	1.31e-03	35	53	2	7757816
Pubmed	A Novel Interacting Protein SERP1 Regulates the N-Linked Glycosylation and Function of GLP-1 Receptor in the Liver.	TMEM176B GLP1R	1.31e-03	35	53	2	28597972
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	ACTR1A THBS4 DST MBOAT7 DSP NIPSNAP1 PLEKHA5 DNAH11	1.37e-03	1431	53	8	37142655
GeneFamily	EF-hand domain containing\|Plakins	DST DSP	1.07e-04	8	36	2	939
GeneFamily	Protein tyrosine phosphatases, non-receptor type	PTPN9 PTPN12	5.78e-04	18	36	2	812
GeneFamily	Taste 2 receptors	TAS2R45 TAS2R46	2.73e-03	39	36	2	1162
Coexpression	CUI_TCF21_TARGETS_2_UP	SLIT2 TMEM176B COMP NIPSNAP1 AKR7A3 UGT2B4 PRMT7	3.51e-05	455	53	7	MM1189
Coexpression	BUSSLINGER_GASTRIC_X_CELLS	PCSK1 DST TMEM176B DSP NIPSNAP1	4.21e-05	191	53	5	M40019
Coexpression	NABA_ECM_GLYCOPROTEINS	SLIT2 THBS2 THBS3 THBS4 COMP	4.21e-05	191	53	5	MM17059
Coexpression	BUSSLINGER_GASTRIC_G_CELLS	PCSK1 DST TMEM176B DSP	4.67e-05	98	53	4	M40018
Coexpression	NABA_ECM_GLYCOPROTEINS	SLIT2 THBS2 THBS3 THBS4 COMP	4.76e-05	196	53	5	M3008
Coexpression	DACOSTA_UV_RESPONSE_VIA_ERCC3_DN	SLIT2 THBS2 PTPN9 PTPN12 MDN1 DST SGMS1 INPP5F CREBBP	4.94e-05	856	53	9	M4500
Coexpression	GSE40277_EOS_AND_LEF1_TRANSDUCED_VS_GATA1_AND_SATB1_TRANSDUCED_CD4_TCELL_UP	PTPN9 CC2D2A GNA15 INPP5F RYR2	5.24e-05	200	53	5	M9169
Coexpression	WONG_ADULT_TISSUE_STEM_MODULE	THBS4 PTPN12 DST TMEM176B NIPSNAP1 PLEKHA5 KIT RYR2	9.36e-05	721	53	8	M1999
ToppCell	COVID-19-Fibroblasts-Other_FB\|COVID-19 / group, cell type (main and fine annotations)	SLIT2 THBS2 DST COMP PLEKHA5 RYR2	9.96e-08	193	52	6	e6b75be08e33c1de079fb5c02f0b4468128b369c
ToppCell	10x_3'_v2v3-Non-neoplastic-Glial-Neuronal-Oligodendrocyte-Oligodendrocyte-B\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	DST TMC7 KCNJ10 CNTNAP4 KCNMB4 INPP5F	1.12e-07	197	52	6	82b8e22317cad6d3786bd70d91107007c0ccd7cd
ToppCell	droplet-Kidney-KIDNEY-1m-Epithelial-Epcam____thick_ascending_tube_S_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLIT2 DST DSP KCNJ10 SPAG5	2.68e-06	188	52	5	14e120b20e76baa07b6510a94f0c2dcdfdd52357
ToppCell	droplet-Kidney-KIDNEY-1m-Epithelial-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLIT2 DST DSP KCNJ10 SPAG5	2.75e-06	189	52	5	443359d90fafae0c1de6bdcce9e8c95df6ea4de8
ToppCell	10x_3'_v2v3-Non-neoplastic-Glial-Neuronal-Oligodendrocyte-Oligodendrocyte-D\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	DST KCNJ10 CNTNAP4 KCNMB4 INPP5F	3.04e-06	193	52	5	947200ef6c3a2e35ad7e6b4af29d92384bdf73f5
ToppCell	Parenchymal-NucSeq-Stromal-Fibroblastic-Fibro_myofibroblast\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	SLIT2 THBS2 DST COMP RYR2	3.36e-06	197	52	5	6d0d68d460243a0259ada93ebda40fa7b3088eeb
ToppCell	Parenchymal-10x3prime_v2-Stromal-Mesofibroblastic\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	FAH THBS3 COMP TTLL1 SPAG5	3.45e-06	198	52	5	0cd930e374c2c48d1991b51c025f9801b22ecee7
ToppCell	Parenchymal-10x3prime_v2-Stromal-Mesofibroblastic-Mesothelia\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	FAH THBS3 COMP TTLL1 SPAG5	3.45e-06	198	52	5	e0df6d6ff2a9c41d813f84a2a5ee7cb5f6fc3e30
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	DST TMC7 KCNJ10 CNTNAP4 KCNMB4	3.62e-06	200	52	5	acdef0b9096c774040948fc75621ff2b08ea2ee8
ToppCell	Control-NK\|World / Disease group and Cell class	DUOX1 DST KCNMB4 KIT	2.35e-05	143	52	4	fe08adc9472dfd4242497d6c614d0490713261da
ToppCell	5'-Adult-LymphNode-Hematopoietic-Myeloid-Lymphoid_DC\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	DUOX1 GNA15 KIT DNAH11	4.21e-05	166	52	4	da10d0be6b616199d49dd922591c2901f9681583
ToppCell	droplet-Thymus-nan-24m-Lymphocytic-Macrophage\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FBXW8 PTPN9 TMEM176B GNA15	4.52e-05	169	52	4	780fb0050852626062a729dd1b82b0cf61e7e9ca
ToppCell	facs-MAT-Fat-3m-Lymphocytic-T_cell\|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PCSK1 TMEM176B GNA15 KIT	5.29e-05	176	52	4	71b3309ddadd035a1224fca4fc5946dc4c0283fe
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-3m-Neuronal-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	REG4 CNTNAP4 PLEKHA5 RYR2	5.77e-05	180	52	4	f6a2208960d0df1500c974cc44c3c054cd7475a9
ToppCell	PND07-Epithelial-Epithelial_Airway-Basal-Basal\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DUOX1 PLB1 DST DSP	5.90e-05	181	52	4	6b43dcaeeb02ad5900772b6f16f1581847050e38
ToppCell	5'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast-Myofibroblasts-Myofibroblasts_L.2.3.2.2\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	THBS2 DST COMP RYR2	5.90e-05	181	52	4	b116c68393d8836bac080f81a8fcbeb52e0403e7
ToppCell	PND07-Epithelial-Epithelial_Airway-Basal\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DUOX1 PLB1 DST DSP	5.90e-05	181	52	4	f50561fdacfb83ba85fe6476e7cbc2bad1ebc826
ToppCell	droplet-Heart-HEART_(LV+RV_ONLY)-30m-Mesenchymal-cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	THBS4 DSP TTLL1 RYR2	6.03e-05	182	52	4	c4a7007c864a9455a7e7447e28ccd380878a6a0f
ToppCell	droplet-Heart-HEART_(LV+RV_ONLY)-30m-Mesenchymal-atrial_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	THBS4 DSP TTLL1 RYR2	6.03e-05	182	52	4	c315d820ffad912c014ba5eac6f5fa6de1a94384
ToppCell	droplet-Kidney-nan-21m-Epithelial-kidney_loop_of_Henle_ascending_limb_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLIT2 DST KCNJ10 RYR2	6.56e-05	186	52	4	8eafd4bea692f7ef33de27dd53f9d1fe67deaad8
ToppCell	5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Alveolar_fibroblasts-Alveolar_fibroblasts_L.2.1.1.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SLIT2 THBS2 DST RYR2	6.56e-05	186	52	4	5473283fb95cee556b1f6934cf72169b676b5bcc
ToppCell	LPS-IL1RA+antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_3\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SLIT2 THBS2 GLP1R RYR2	6.56e-05	186	52	4	a95744b8649096bd7cfc3591a02841fa411085b3
ToppCell	COVID-19-Fibroblasts-Airway_smooth_muscle\|COVID-19 / group, cell type (main and fine annotations)	SLIT2 THBS2 DST RYR2	6.69e-05	187	52	4	464a0c3b92b778911b5f9cd73642e09e3472063a
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SLIT2 THBS2 DST RYR2	7.12e-05	190	52	4	2e88e366d377d74deb53a4ea870973ce5c6532e8
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SLIT2 THBS2 DST RYR2	7.12e-05	190	52	4	0028f886c789ba238c031eae5d96acaed4af8c25
ToppCell	LPS-IL1RA-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_3\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SLIT2 THBS2 GLP1R RYR2	7.12e-05	190	52	4	73d94fbae92029745989a8712eed8b99fd84c193
ToppCell	Control-Fibroblasts\|Control / group, cell type (main and fine annotations)	SLIT2 THBS2 DST RYR2	7.12e-05	190	52	4	3a42a9b98d954685d38a741f44545898d0e3e9ce
ToppCell	ASK454-Mesenchymal\|ASK454 / Donor, Lineage and Cell class of Lung cells from Dropseq	SLIT2 DST COMP RYR2	7.27e-05	191	52	4	e30ae7a12439f8a79820b13f03e822c1223fd0cb
ToppCell	ASK454-Mesenchymal-Fibroblast\|ASK454 / Donor, Lineage and Cell class of Lung cells from Dropseq	SLIT2 DST COMP RYR2	7.27e-05	191	52	4	1726add3f392a061536b7aff72ba84303f4a0b1f
ToppCell	Children_(3_yrs)-Mesenchymal-matrix_fibroblast_1_cell\|Children_(3_yrs) / Lineage, Cell type, age group and donor	SLIT2 DST UGT2B4 RYR2	7.56e-05	193	52	4	99525545552b371c86b18b6ea6f4897dc6e9a9ec
ToppCell	Adult-Mesenchymal-matrix_fibroblast_1_cell-D231\|Adult / Lineage, Cell type, age group and donor	SLIT2 THBS2 UGT2B4 RYR2	7.56e-05	193	52	4	ef2f456c094e6e3c6ee81e0668c953cb8d0e1c0a
ToppCell	HSPCs-Ery_prog.\|World / Lineage and Cell class	AASDHPPT GNA15 PRMT7 KIT	7.56e-05	193	52	4	484c2e0daedc6cb0d50d164add8c1658123a60f9
ToppCell	Control-Fibroblasts-Intermediate_pathological_FB\|Control / group, cell type (main and fine annotations)	SLIT2 THBS2 DST RYR2	7.72e-05	194	52	4	03a269f75a481ea54aea8e6444605db8d6df493d
ToppCell	Mesenchymal_cells-Arteriolar_fibro.\|World / Lineage and Cell class	THBS2 THBS3 THBS4 COMP	7.72e-05	194	52	4	c1e8923a50b4138a1e4c054c0c17b7f7122aa8a9
ToppCell	Fetal_29-31_weeks-Mesenchymal-matrix_fibroblast_1_cell-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	SLIT2 DST UGT2B4 RYR2	7.72e-05	194	52	4	35f132cc38ac133be01834ed0946188aa0757eb4
ToppCell	droplet-Limb_Muscle-nan-21m-Mesenchymal-chondrocyte-like\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	THBS2 THBS4 TMEM176B COMP	7.87e-05	195	52	4	d2c9c58b46bf96f9a536e177b995e340b55c6750
ToppCell	ASK428-Mesenchymal\|ASK428 / Donor, Lineage and Cell class of Lung cells from Dropseq	SLIT2 THBS2 TMEM176B COMP	7.87e-05	195	52	4	2b156163975d9a3d3fda1402acd9831d0fdc9e25
ToppCell	COVID-19-Fibroblasts-Alveolar_FB\|COVID-19 / group, cell type (main and fine annotations)	SLIT2 DST PLEKHA5 RYR2	7.87e-05	195	52	4	603050beeb33c331d4b2e3fa46cae3f3e0e4bdc7
ToppCell	ASK428-Mesenchymal-Fibroblast\|ASK428 / Donor, Lineage and Cell class of Lung cells from Dropseq	SLIT2 THBS2 TMEM176B COMP	7.87e-05	195	52	4	c269c0d894a0f55da6495b59d4b9abb9f68df684
ToppCell	hematopoetic_progenitors-CD34+_MPP\|World / Lineage and Cell class	FAH MBOAT7 GNA15 KIT	7.87e-05	195	52	4	851064ca1ab727b4972ad4b72234ee130998a799
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Oligodendrocyte-Oligodendrocyte-A\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	PCSK1 CNTNAP4 KCNMB4 INPP5F	7.87e-05	195	52	4	1e28617ca55e5f318a228357737b968dfac8cca0
ToppCell	367C-Fibroblasts-Fibroblast-C_(Myofibroblast)-\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	SLIT2 DST TMEM176B UGT2B4	8.03e-05	196	52	4	6730743cf088c419ccc2d28765769fc09d3ba6a7
ToppCell	3'-Broncho-tracheal-Mesenchymal-Fibroblastic-fibroblastic_type_2-Peribronchial_fibroblasts-Peribronchial_fibroblasts_L.2.1.3.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SLIT2 THBS2 TMEM176B COMP	8.03e-05	196	52	4	e7bfd4fb400ae0c473131d0fa306c26be08a6d03
ToppCell	3'-Broncho-tracheal-Mesenchymal-Fibroblastic-fibroblastic_type_2-Peribronchial_fibroblasts\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SLIT2 THBS2 TMEM176B COMP	8.03e-05	196	52	4	82fad623212d986a7fca3496faf3f8c8f5b83a11
ToppCell	droplet-Limb_Muscle-nan-24m-Mesenchymal-chondrocyte-like\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	THBS2 THBS4 TMEM176B COMP	8.03e-05	196	52	4	61bee32ca299219f31a30b57124e44e85b798e9f
ToppCell	IPF-Stromal-Myofibroblast\|World / Disease state, Lineage and Cell class	SLIT2 THBS2 COMP RYR2	8.03e-05	196	52	4	7fc9894ceb79dab9f0495acc84e2d6d0d1c69bb7
ToppCell	367C-Fibroblasts-Fibroblast-C_(Myofibroblast)\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	SLIT2 DST TMEM176B UGT2B4	8.03e-05	196	52	4	21dab89f3699037138a9c7a0e4dc98739a9fad9c
ToppCell	droplet-Limb_Muscle-nan-18m-Mesenchymal-chondrocyte-like\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	THBS2 THBS4 TMEM176B COMP	8.03e-05	196	52	4	fcb275746bf51269ed8ba4cf93edb054a45f1ccd
ToppCell	IPF-Stromal-Myofibroblast\|IPF / Disease state, Lineage and Cell class	SLIT2 THBS2 COMP RYR2	8.03e-05	196	52	4	2d0a48e49b3b37bb66e33e74c52915911e1f8a74
ToppCell	3'-Broncho-tracheal-Mesenchymal-Fibroblastic-fibroblastic_type_2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SLIT2 THBS2 TMEM176B COMP	8.03e-05	196	52	4	85e5046f774537684e1443c0fc147d562b7068d0
ToppCell	nucseq-Mesenchymal-Fibroblastic\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	SLIT2 THBS2 DST RYR2	8.03e-05	196	52	4	7d8505dac15fa59935ccf592afc54b04c4c6554f
ToppCell	COVID-19-Fibroblasts-Intermediate_pathological_FB\|COVID-19 / group, cell type (main and fine annotations)	SLIT2 THBS2 DST RYR2	8.19e-05	197	52	4	f1c8936986123a3151140c374fcd62d6705c530b
ToppCell	COVID-19-Fibroblasts\|COVID-19 / group, cell type (main and fine annotations)	SLIT2 THBS2 DST RYR2	8.19e-05	197	52	4	fb847f2277609c31fffcdf49517243ce0684facf
ToppCell	droplet-Limb_Muscle-MUSCLE-30m-Mesenchymal-chondrocyte-like\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	THBS2 THBS4 TMEM176B COMP	8.19e-05	197	52	4	cfd4cc5fb8d7a60dd5c0d2a1a7bad7ba38c19d40
ToppCell	Mesenchymal_cells-Arteriolar_fibro.\|Mesenchymal_cells / Lineage and Cell class	THBS2 THBS3 THBS4 COMP	8.19e-05	197	52	4	cb321836980e7b4efbb9284c6af7ccd34079d2be
ToppCell	IPF-Stromal-Myofibroblast\|Stromal / Disease state, Lineage and Cell class	SLIT2 COMP PLEKHA5 RYR2	8.19e-05	197	52	4	f304d42fc4936fe20996e07c8dccc698a6e5e5ef
ToppCell	COVID-19-lung-Fibroblast\|COVID-19 / Disease (COVID-19 only), tissue and cell type	SLIT2 THBS2 DST RYR2	8.35e-05	198	52	4	3ec01a55ade5e1627258cc3cfebb2c3207a4cb43
ToppCell	10x_3'_v2v3-Non-neoplastic-Glial-Neuronal-Oligodendrocyte-Oligodendrocyte-G\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	TMC7 KCNJ10 CNTNAP4 KCNMB4	8.35e-05	198	52	4	bdabdb11217ea16e5863aa6bfb0f04d48b17f81e
ToppCell	Parenchymal-10x5prime-Stromal-Fibroblastic-Fibro_peribronchial\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	SLIT2 THBS2 TMEM176B COMP	8.35e-05	198	52	4	300d7cc56207d77168390fa1ffcbcf76767b1b80
ToppCell	COVID-19-lung-Fibroblast\|lung / Disease (COVID-19 only), tissue and cell type	SLIT2 THBS2 DST RYR2	8.35e-05	198	52	4	df3de77216f5c5d6141ec44d01c56b942f611838
ToppCell	distal-1-mesenchymal-Alveolar_Fibroblast\|1 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	SLIT2 TMEM176B UGT2B4 RYR2	8.35e-05	198	52	4	6594c35ab203dc51462167c61807b0d49fa30fb2
ToppCell	nucseq-Mesenchymal\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	SLIT2 THBS2 DST RYR2	8.35e-05	198	52	4	8f52243ca8b9ba68a75ae411506a3a6de258eb97
ToppCell	droplet-Limb_Muscle-MUSCLE-1m-Mesenchymal-chondrocyte-like\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	THBS2 THBS3 THBS4 COMP	8.35e-05	198	52	4	524305c5d7b1d53e86ec0af775efefa3e0955e47
ToppCell	(1)_Osterolineage_cells-(11)_OLC-2\|(1)_Osterolineage_cells / Cell class and subclass of bone marrow stroma cells in homeostatis	THBS2 THBS3 THBS4 COMP	8.35e-05	198	52	4	9f9dcf23ffb333105263132d87b90095642294cf
ToppCell	Fetal_29-31_weeks-Mesenchymal\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	SLIT2 THBS2 DST RYR2	8.35e-05	198	52	4	21cf4d81386761d09d0f6829c01c198e5524176d
ToppCell	proximal-mesenchymal-Alveolar_Fibroblast\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	SLIT2 DST TMEM176B UGT2B4	8.51e-05	199	52	4	7f4840ae6a888380feca722543e5e52783f3e35d
ToppCell	proximal-3-mesenchymal-Alveolar_Fibroblast\|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	SLIT2 DST TMEM176B UGT2B4	8.51e-05	199	52	4	301d02bbb37e6f1d24b6e865bc3fe3e91260eb30
ToppCell	Mesenchymal\|World / Lineage, Cell type, age group and donor	SLIT2 THBS2 DST RYR2	8.51e-05	199	52	4	4bac110c2b3609f6ee5d0e3275da0824a6240270
ToppCell	proximal-mesenchymal-Alveolar_Fibroblast-3\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	SLIT2 DST TMEM176B UGT2B4	8.51e-05	199	52	4	9a16e519fb0651a7c4d8e05b931df4fb3b0eb3d1
ToppCell	mLN-ILC-ILC\|mLN / Region, Cell class and subclass	DST MBOAT7 GNA15 KIT	8.51e-05	199	52	4	ab09a06cdea2597e9fe4b4b304655e9de4d433f6
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Oligodendrocyte-Oligodendrocyte-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	DST TMC7 CNTNAP4 KCNMB4	8.51e-05	199	52	4	214a6a267e77e5508867b9eb48c4fbc7855ed0a0
ToppCell	mLN-ILC\|mLN / Region, Cell class and subclass	DST MBOAT7 GNA15 KIT	8.51e-05	199	52	4	d6c299312c747fb1b7c53644c53efc03a5fffe85
ToppCell	mLN-(3)_ILC\|mLN / shred on region, Cell_type, and subtype	DST MBOAT7 GNA15 KIT	8.51e-05	199	52	4	00e0e2a766dd9c4d0a65f53d88fa50df4b6a3d60
ToppCell	distal-mesenchymal-Alveolar_Fibroblast-3\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	SLIT2 DST TMEM176B UGT2B4	8.51e-05	199	52	4	fb23ecce41e31e2cc01814e3c0add756f489561f
ToppCell	Fibroblasts-CD34+_Fibroblasts\|World / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues	THBS2 THBS4 DST COMP	8.51e-05	199	52	4	13ff7409e200a0b46cdb7924d15ef33639693622
ToppCell	343B-Fibroblasts-Fibroblast-G\|343B / Donor, Lineage, Cell class and subclass (all cells)	SLIT2 DST TMEM176B RYR2	8.51e-05	199	52	4	f4b6c095cbe7a38b310adc49be4069e4d56e6a66
ToppCell	mLN-(3)_ILC-(30)_ILC\|mLN / shred on region, Cell_type, and subtype	DST MBOAT7 GNA15 KIT	8.51e-05	199	52	4	33ac6d77099076df01299be429f4ba96f2f34cc1
ToppCell	343B-Fibroblasts-Fibroblast-G-\|343B / Donor, Lineage, Cell class and subclass (all cells)	SLIT2 DST TMEM176B RYR2	8.51e-05	199	52	4	9c6d1c328bfbb6547f4c7bb2a784576a56bd72af
ToppCell	343B-Fibroblasts\|343B / Donor, Lineage, Cell class and subclass (all cells)	SLIT2 THBS2 DST TMEM176B	8.68e-05	200	52	4	376c1a77031e090be96948b47c78ac0d393f5775
ToppCell	Bronchial-NucSeq-Stromal\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	SLIT2 THBS2 DST RYR2	8.68e-05	200	52	4	389cc775c8419d90fb77cd794376d2160a7bf44e
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Oligodendrocyte-Oligodendrocyte\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	TMC7 KCNJ10 CNTNAP4 KCNMB4	8.68e-05	200	52	4	091a18d6efed81cab99955c3047f172170f70476
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Oligodendrocyte\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	TMC7 KCNJ10 CNTNAP4 KCNMB4	8.68e-05	200	52	4	3b8513defe25262ab4b492345b2628570eaefd17
ToppCell	Parenchymal-NucSeq-Stromal\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	SLIT2 THBS2 DST RYR2	8.68e-05	200	52	4	cf433f9b43d7db07acaf70e060f8f77c974e72f3
ToppCell	Bronchial-NucSeq-Stromal-Fibroblastic\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	SLIT2 THBS2 DST RYR2	8.68e-05	200	52	4	cae972324d1dfea6efeaf6013f265c7c6bb48db4
ToppCell	Parenchymal-NucSeq-Stromal-Fibroblastic\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	SLIT2 THBS2 DST RYR2	8.68e-05	200	52	4	311fab076f2ceb258e3970eb21e39344b894042a
ToppCell	Sepsis-ICU-NoSEP-Myeloid-cDC1\|ICU-NoSEP / Disease, condition lineage and cell class	DST PLEKHA5 GNA15 KIT	8.68e-05	200	52	4	511e642575182fb678df6791ee6539b0ced3eb17
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Pvalb-Pvalb_Gabrg1\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	SLIT2 GLP1R CNTNAP4	3.54e-04	118	52	3	3f0a304ef9c9e5ba047fc09f4372590eed624328
ToppCell	Hippocampus-Neuronal-Excitatory-eN1(Slc17a7)-eN1_1-C1ql2-Excitatory_Neuron.Slc17a7.C1ql2-Cck_(Dentate_Principal_cells)\|Hippocampus / BrainAtlas - Mouse McCarroll V32	PLB1 SUSD1 DSP	4.59e-04	129	52	3	08ecebb7f09d105dfdfd2191fc310910d3baec0f
ToppCell	TCGA-Lung-Primary_Tumor-Lung_Carcinoma-Lung_Adenocarcinoma_Mixed_Subtype-8\|TCGA-Lung / Sample_Type by Project: Shred V9	PCSK1 AKR7A3 UGT2B4	5.47e-04	137	52	3	05ca83c30e3dbe74c81278b3636d57da2c20b458
ToppCell	droplet-Liver-LIVER_HEP-30m-Epithelial-hepatocyte\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FAH NIPSNAP1 AASDHPPT	7.12e-04	150	52	3	42fd42a0be918a77aca4e0c91f068bdd5a5d9286
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Mesenchymal-fibroblastic-Stromal_3_(KCNN3+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SLIT2 THBS2 AKR7A3	7.12e-04	150	52	3	909ccab92855f5f049dc29593aadab1ea973297b
ToppCell	droplet-Liver-LIVER_HEP-30m-Epithelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FAH NIPSNAP1 AASDHPPT	7.12e-04	150	52	3	c2fcdd62ec85cbf9783a525cd7556e16a1e55cd8
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Connecting_Tubule_Intercalated_Cell_Type_A\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SLIT2 SUSD1 KIT	7.12e-04	150	52	3	87968ce885a4959616f0321f58517fe8029ba1b1
ToppCell	normal_Lung-Myeloid_cells-Pleural_Mac\|Myeloid_cells / Location, Cell class and cell subclass	THBS4 TMEM176B MBOAT7	7.69e-04	154	52	3	835ef49d314ecbcbfd8d1041ba202a5eedcda0bd
ToppCell	droplet-Heart-HEART_(ALL_4:4:4:1:1)-30m-Endothelial-endocardial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SUSD1 NIPSNAP1 INPP5F	8.13e-04	157	52	3	a426c54fd1545093d41426e9620862f71bd06f6b
ToppCell	Control-B_naive-12\|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)	DST KCNMB4 NEMP2	8.13e-04	157	52	3	4803f601c1ba43260aa09172acc7964aac2c8ccf
ToppCell	Control-B_naive-12\|Control / disease group and sub_cluster of B and Plasma cells(res = 0.5)	DST KCNMB4 NEMP2	8.28e-04	158	52	3	41318f864770370ce77ed3fa4a84f76c0c22c482
ToppCell	Adult-Mesenchymal-chondrocyte\|Adult / Lineage, Cell type, age group and donor	SLIT2 THBS2 RYR2	8.43e-04	159	52	3	3f7305ee76447064b5c846c4f576360a2f7e0b7c
ToppCell	PND07-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_prolif\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FAH THBS2 DNAH11	8.43e-04	159	52	3	7ed659163f45e0c4df4782997c0786900c8186c8
ToppCell	droplet-Kidney-KIDNEY-1m-Lymphocytic-lymphocyte\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	THBS4 COMP GNA15	8.43e-04	159	52	3	3bab00f8fb7d9232538e50f83dd0fd70ddd16819
Disease	visceral heterotaxy (implicated_via_orthology)	SLIT2 CC2D2A DNAH11	3.42e-05	37	50	3	DOID:0050545 (implicated_via_orthology)
Disease	Small cell carcinoma of lung	SLIT2 KIT CREBBP	1.07e-04	54	50	3	C0149925
Disease	arrhythmogenic right ventricular cardiomyopathy (is_implicated_in)	DSP RYR2	1.26e-04	10	50	2	DOID:0050431 (is_implicated_in)
Disease	Kartagener syndrome (implicated_via_orthology)	SLIT2 DNAH11	2.53e-04	14	50	2	DOID:0050144 (implicated_via_orthology)
Disease	hyperglycemia (implicated_via_orthology)	PCSK1 GLP1R	3.77e-04	17	50	2	DOID:4195 (implicated_via_orthology)
Disease	acute myeloid leukemia (is_implicated_in)	FANCC KIT CREBBP	3.96e-04	84	50	3	DOID:9119 (is_implicated_in)
Disease	primary ciliary dyskinesia (implicated_via_orthology)	SLIT2 TTLL1	4.72e-04	19	50	2	DOID:9562 (implicated_via_orthology)
Disease	granulocyte count	MED24 REG4 KCNJ10 KIT	9.05e-04	254	50	4	EFO_0007987
Disease	body weight	PCSK1 SLIT2 PTPN9 SUSD1 CNTNAP4 HUWE1 PRMT7 KIT	1.18e-03	1261	50	8	EFO_0004338
Disease	joint hypermobility measurement	THBS2 CC2D2A	1.44e-03	33	50	2	EFO_0007905

Protein segments in the cluster

Peptide	Gene	Start	Entry
EWTQLDMFYRNWALK	AASDHPPT	166	Q9NRN7
NTWAEMYRNRYWKEH	AKR7A3	226	O95154
VVMWKQMEQTYWQAN	COMP	611	P49747
TSKPMYRRWWEQFVQ	CCNK	226	O75909
DVWLMFNNAWLYNRK	CREBBP	1156	Q92793
LMFSDSGWNWKQYRQ	CNTNAP4	111	Q9C0A0
YQADFSRWWQKEMKA	DNAH11	2426	Q96DT5
NTYRDFWLMVWEQKV	PTPN9	381	P43378
SWEVQRFDGWYNNLM	DUOX1	26	Q9NRD9
RATNQDWMLRVKWLY	MDN1	2526	Q9NU22
YLKDLWTTFIDMQWR	KCNJ10	51	P78508
QQWIYMNRTFTDKWE	KIT	346	P10721
LKWMYSTAAQQHQWD	GLP1R	201	P43220
IEAYRAAMQTQWSWI	DST	776	Q03001
LVSVWDYRMNQKLWE	FBXW8	496	Q8N3Y1
NQNSQVEWKYIWSTM	NEMP2	56	A6NFY4
NMTVQWWLAQYIYKS	MBOAT7	321	Q96N66
ISDWLYVQKMNTWFK	FMO6P	251	O60774
TFEKRYAAAMQWLWR	GNA15	126	P30679
MTKYLQSNSNNWRWF	HUWE1	1606	Q7Z6Z7
MEEYRTSLQQWKAWR	CC2D2A	571	Q9P2K1
YAQLVESGRMWSWNK	PRMT7	181	Q9NVM4
KIEAYMDTLQTQWSW	DSP	346	P15924
DYQFWMQKLSVWDQA	FANCC	11	Q00597
KDWNDMERIWQYVYS	ACTR1A	81	P61163
NLESVMNWQQYWKDE	KCNMB4	126	Q86W47
MNDWSARDIQKWEYV	FAH	231	P16930
LWQKVDDRFFWNKYM	INPP5F	201	Q9Y2H2
QESYVWKMYQERCWE	RYR2	4936	Q92736
KRQQWQWIDGAMYLY	REG4	101	Q9BYZ8
TMIEWGNNWARAIKY	NIPSNAP1	196	Q9BPW8
QIVWTKEYEGNMTWK	TAS2R45	151	P59539
QIIWTKEYEGNMTWK	TAS2R46	151	P59540
LQQDWRSMQLDYTTW	SPAG5	641	Q96R06
ERWSDYQWAINMKKF	MED24	16	O75448
ANTVIDFWRMIWEYN	PTPN12	111	Q05209
MTTSFWKRRNWYVDD	MRPL35	161	Q9NZE8
VVMQWSYQEAWNSLL	PLB1	251	Q6P1J6
YRWMRRSQENQWQKE	TMEM176B	176	Q3YBM2
DIWKMYKQAQASFWT	RRM2B	51	Q7LG56
ESWGNNMVVRVKWFY	TNRC18	2846	O15417
VMWKQTEQTYWQATP	THBS4	811	P35443
WSYFSQVQEIMWTFN	UGT2B4	106	P06133
WGQRWYQKEFAQEMT	SUSD1	526	Q6UWL2
TRLFWWYHTMANQQV	SGMS1	341	Q86VZ5
NMQWLSDWVKSEYKE	SLIT2	866	O94813
VVMWKQTEQTYWQAT	THBS3	806	P49746
MWKQVTQTYWEDQPT	THBS2	1041	P35442
RDDTMWQLYEWQQRQ	PLEKHA5	496	Q9HAU0
VMWENYTNVMSVENW	ZNF214	31	Q9UL59
VQVTENEDWNFYWMS	TTLL1	26	O95922
NEDWNFYWMSVQTIR	TTLL1	31	O95922
IQETQMKYLSEWDQW	TMC7	106	Q7Z402
WNQQWYLQDTRMTAA	PCSK1	126	P29120