Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	ferroxidase activity	HEPHL1 HEPH	9.53e-05	6	51	2	GO:0004322
GeneOntologyMolecularFunction	oxidoreductase activity, acting on metal ions, oxygen as acceptor	HEPHL1 HEPH	9.53e-05	6	51	2	GO:0016724
GeneOntologyMolecularFunction	CCR1 chemokine receptor binding	CCL4L1 CCL4	4.15e-04	12	51	2	GO:0031726
GeneOntologyMolecularFunction	CCR5 chemokine receptor binding	CCL4L1 CCL4	4.90e-04	13	51	2	GO:0031730
GeneOntologyMolecularFunction	glycerophospholipid flippase activity	ATP8A2 ATP8B2	5.71e-04	14	51	2	GO:0140333
GeneOntologyMolecularFunction	floppase activity	ATP8A2 ATP8B2	7.50e-04	16	51	2	GO:0140328
GeneOntologyMolecularFunction	flippase activity	ATP8A2 ATP8B2	8.49e-04	17	51	2	GO:0140327
GeneOntologyMolecularFunction	ATP hydrolysis activity	ATP8A2 CHD5 MCM9 DNAH2 ATP8B2 DYNC1H1	8.71e-04	441	51	6	GO:0016887
GeneOntologyMolecularFunction	ATP-dependent activity	IPO8 ATP8A2 CHD5 MCM9 DNAH2 ATP8B2 DYNC1H1	8.98e-04	614	51	7	GO:0140657
GeneOntologyMolecularFunction	minus-end-directed microtubule motor activity	DNAH2 DYNC1H1	9.53e-04	18	51	2	GO:0008569
GeneOntologyMolecularFunction	oxidoreductase activity, acting on metal ions	HEPHL1 HEPH	9.53e-04	18	51	2	GO:0016722
GeneOntologyMolecularFunction	copper ion binding	HEPHL1 F5 HEPH	1.04e-03	78	51	3	GO:0005507
GeneOntologyMolecularFunction	RNA cap binding	LARP1 EIF4G3	1.30e-03	21	51	2	GO:0000339
GeneOntologyMolecularFunction	dynein light intermediate chain binding	DNAH2 DYNC1H1	2.32e-03	28	51	2	GO:0051959
GeneOntologyMolecularFunction	ATPase-coupled intramembrane lipid transporter activity	ATP8A2 ATP8B2	2.32e-03	28	51	2	GO:0140326
GeneOntologyMolecularFunction	low-density lipoprotein particle receptor binding	LRP2 APOB	3.41e-03	34	51	2	GO:0050750
GeneOntologyMolecularFunction	cytoskeletal motor activity	DNAI1 DNAH2 DYNC1H1	3.41e-03	118	51	3	GO:0003774
GeneOntologyCellularComponent	excitatory synapse	RAB3GAP1 NETO1 ITGA3 UNC13A	1.45e-04	107	52	4	GO:0060076
GeneOntologyCellularComponent	Cul5-RING ubiquitin ligase complex	KLHDC1 ASB4	2.70e-04	10	52	2	GO:0031466
GeneOntologyCellularComponent	axon	PTPN5 SCN11A NETO1 DYRK1A LRP2 EXOC3 ITGA3 UNC13A DYNC1H1	3.15e-04	891	52	9	GO:0030424
GeneOntologyCellularComponent	dynein complex	DNAI1 DNAH2 DYNC1H1	3.29e-04	54	52	3	GO:0030286
GeneOntologyCellularComponent	phospholipid-translocating ATPase complex	ATP8A2 ATP8B2	5.42e-04	14	52	2	GO:1990531
GeneOntologyCellularComponent	synaptic membrane	PTPN5 SCN11A NETO1 EXOC3 CNKSR2 ITGA3 UNC13A	5.70e-04	583	52	7	GO:0097060
Domain	Cu_oxidase_CS	HEPHL1 F5 HEPH	2.03e-07	5	52	3	IPR033138
Domain	Cu-oxidase_3	HEPHL1 F5 HEPH	2.03e-07	5	52	3	IPR011707
Domain	MULTICOPPER_OXIDASE1	HEPHL1 F5 HEPH	2.03e-07	5	52	3	PS00079
Domain	Cu-oxidase_3	HEPHL1 F5 HEPH	2.03e-07	5	52	3	PF07732
Domain	Cu_oxidase_Cu_BS	HEPHL1 F5 HEPH	4.05e-07	6	52	3	IPR002355
Domain	-	HEPHL1 F5 HEPH	7.25e-06	14	52	3	2.60.40.420
Domain	Cse1	IPO8 IPO7	2.28e-05	3	52	2	IPR013713
Domain	MULTICOPPER_OXIDASE2	HEPHL1 HEPH	2.28e-05	3	52	2	PS00080
Domain	Cse1	IPO8 IPO7	2.28e-05	3	52	2	PF08506
Domain	Cupredoxin	HEPHL1 F5 HEPH	3.02e-05	22	52	3	IPR008972
Domain	Cu-oxidase_2	HEPHL1 HEPH	4.55e-05	4	52	2	IPR011706
Domain	Cu-oxidase_2	HEPHL1 HEPH	4.55e-05	4	52	2	PF07731
Domain	DHC_N1	DNAH2 DYNC1H1	2.11e-04	8	52	2	PF08385
Domain	Dynein_heavy_dom-1	DNAH2 DYNC1H1	2.11e-04	8	52	2	IPR013594
Domain	Dynein_heavy_chain_D4_dom	DNAH2 DYNC1H1	6.77e-04	14	52	2	IPR024317
Domain	Dynein_HC_stalk	DNAH2 DYNC1H1	6.77e-04	14	52	2	IPR024743
Domain	Dynein_heavy_dom-2	DNAH2 DYNC1H1	6.77e-04	14	52	2	IPR013602
Domain	DHC_N2	DNAH2 DYNC1H1	6.77e-04	14	52	2	PF08393
Domain	IMPORTIN_B_NT	IPO8 IPO7	6.77e-04	14	52	2	PS50166
Domain	MT	DNAH2 DYNC1H1	6.77e-04	14	52	2	PF12777
Domain	AAA_8	DNAH2 DYNC1H1	6.77e-04	14	52	2	PF12780
Domain	P_typ_ATPase_c	ATP8A2 ATP8B2	6.77e-04	14	52	2	IPR032630
Domain	P-type_ATPase_N	ATP8A2 ATP8B2	6.77e-04	14	52	2	IPR032631
Domain	ATPase_dyneun-rel_AAA	DNAH2 DYNC1H1	6.77e-04	14	52	2	IPR011704
Domain	P-type_ATPase_IV	ATP8A2 ATP8B2	6.77e-04	14	52	2	IPR006539
Domain	PhoLip_ATPase_C	ATP8A2 ATP8B2	6.77e-04	14	52	2	PF16212
Domain	PhoLip_ATPase_N	ATP8A2 ATP8B2	6.77e-04	14	52	2	PF16209
Domain	AAA_5	DNAH2 DYNC1H1	6.77e-04	14	52	2	PF07728
Domain	DHC_fam	DNAH2 DYNC1H1	7.80e-04	15	52	2	IPR026983
Domain	IBN_N	IPO8 IPO7	7.80e-04	15	52	2	PF03810
Domain	Dynein_heavy_dom	DNAH2 DYNC1H1	7.80e-04	15	52	2	IPR004273
Domain	Dynein_heavy	DNAH2 DYNC1H1	7.80e-04	15	52	2	PF03028
Domain	IBN_N	IPO8 IPO7	8.90e-04	16	52	2	SM00913
Domain	Importin-beta_N	IPO8 IPO7	1.01e-03	17	52	2	IPR001494
Domain	Cadherin_cytoplasmic-dom	CDH5 CDH15	2.19e-03	25	52	2	IPR000233
Domain	Cadherin_C	CDH5 CDH15	2.19e-03	25	52	2	PF01049
Domain	ARM-type_fold	IPO8 IPO7 INTS1 APOB EIF4G3	2.47e-03	339	52	5	IPR016024
Domain	Catenin_binding_dom	CDH5 CDH15	2.94e-03	29	52	2	IPR027397
Domain	-	CDH5 CDH15	2.94e-03	29	52	2	4.10.900.10
Domain	-	ATP8A2 ATP8B2	3.57e-03	32	52	2	3.40.1110.10
Domain	-	ATP8A2 ATP8B2	3.57e-03	32	52	2	2.70.150.10
Domain	ATPase_P-typ_cyto_domN	ATP8A2 ATP8B2	4.27e-03	35	52	2	IPR023299
Domain	P_typ_ATPase	ATP8A2 ATP8B2	4.51e-03	36	52	2	IPR001757
Domain	ATPase_P-typ_P_site	ATP8A2 ATP8B2	4.51e-03	36	52	2	IPR018303
Domain	ATPASE_E1_E2	ATP8A2 ATP8B2	4.51e-03	36	52	2	PS00154
Domain	ATPase_P-typ_transduc_dom_A	ATP8A2 ATP8B2	4.76e-03	37	52	2	IPR008250
Domain	E1-E2_ATPase	ATP8A2 ATP8B2	4.76e-03	37	52	2	PF00122
Domain	LDLR_class-A_CS	NETO1 LRP2	5.54e-03	40	52	2	IPR023415
Pubmed	Identification and characterization of two genes (MIP-1beta, VE-CADHERIN) implicated in acute rejection in human heart transplantation: use of murine models in tandem with cDNA arrays.	CCL4L1 CCL4 CDH5	1.34e-08	4	53	3	15897346
Pubmed	Genetic polymorphisms associated with thrombophilia and vascular disease in women with unexplained late intrauterine fetal death: a multicenter study.	APOB ITGA3 F5	3.98e-07	10	53	3	14706682
Pubmed	A neomorphic cancer cell-specific role of MAGE-A4 in trans-lesion synthesis.	LRPPRC IPO7 RCN1 ITGA3 DYNC1H1	1.04e-06	118	53	5	27377895
Pubmed	Flt3 ligand induces tyrosine phosphorylation of gab1 and gab2 and their association with shp-2, grb2, and PI3 kinase.	FLT3 SHC1	2.28e-06	2	53	2	11027663
Pubmed	Cloning and expression of a lymphocyte activation gene (LAG-1).	CCL4L1 CCL4	2.28e-06	2	53	2	2247088
Pubmed	Truncated apo B-70.5-containing lipoproteins bind to megalin but not the LDL receptor.	LRP2 APOB	2.28e-06	2	53	2	10330424
Pubmed	Systematic Analysis of Human Protein Phosphatase Interactions and Dynamics.	PTPN5 LRPPRC IPO8 IPO7 INTS1 PPP2R3B DYNC1H1 TP53BP2	2.39e-06	573	53	8	28330616
Pubmed	Inhibition of macrophage inflammatory protein-1β improves endothelial progenitor cell function and ischemia-induced angiogenesis in diabetes.	CCL4L1 CCL4	6.83e-06	3	53	2	29987448
Pubmed	The gene encoding the Act-2 cytokine. Genomic structure, HTLV-I/Tax responsiveness of 5' upstream sequences, and chromosomal localization.	CCL4L1 CCL4	6.83e-06	3	53	2	1894635
Pubmed	A Novel Resolution of Diabetes: C-C Chemokine Motif Ligand 4 Is a Common Target in Different Types of Diabetes by Protecting Pancreatic Islet Cell and Modulating Inflammation.	CCL4L1 CCL4	6.83e-06	3	53	2	33968046
Pubmed	High-resolution solution structure of the beta chemokine hMIP-1 beta by multidimensional NMR.	CCL4L1 CCL4	6.83e-06	3	53	2	8134838
Pubmed	Critical role of CCL4 in eosinophil recruitment into the airway.	CCL4L1 CCL4	6.83e-06	3	53	2	30854716
Pubmed	Multiple products derived from two CCL4 loci: high incidence of a new polymorphism in HIV+ patients.	CCL4L1 CCL4	6.83e-06	3	53	2	15843566
Pubmed	Identification, cloning, and characterization of an immune activation gene.	CCL4L1 CCL4	6.83e-06	3	53	2	2462251
Pubmed	Preferential utilization of Imp7/8 in nuclear import of Smads.	IPO8 IPO7	6.83e-06	3	53	2	18519565
Pubmed	An ATF/CREB-binding site is essential for cell-specific and inducible transcription of the murine MIP-1 beta cytokine gene.	CCL4L1 CCL4	6.83e-06	3	53	2	7835696
Pubmed	Vascular endothelial growth factor induces SHC association with vascular endothelial cadherin: a potential feedback mechanism to control vascular endothelial growth factor receptor-2 signaling.	SHC1 CDH5	6.83e-06	3	53	2	11950700
Pubmed	The human MIP-1beta chemokine is encoded by two paralogous genes, ACT-2 and LAG-1.	CCL4L1 CCL4	6.83e-06	3	53	2	11685466
Pubmed	Involvement of CD4+ and CD8+ T-lymphocytes in the modulation of nociceptive processing evoked by CCL4 in mice.	CCL4L1 CCL4	6.83e-06	3	53	2	34999112
Pubmed	CCL4 protects from type 1 diabetes by altering islet beta-cell-targeted inflammatory responses.	CCL4L1 CCL4	6.83e-06	3	53	2	17327452
Pubmed	Phosphorylation screening identifies translational initiation factor 4GII as an intracellular target of Ca(2+)/calmodulin-dependent protein kinase I.	CAMK1 EIF4G3	6.83e-06	3	53	2	14507913
Pubmed	Isolation and characterization of a cDNA encoding a putative cytokine which is induced by stimulation via the CD2 structure on human T lymphocytes.	CCL4L1 CCL4	6.83e-06	3	53	2	2568930
Pubmed	[Ceruloplasmin, hephaestin and zyklopen: the three multicopper oxidases important for human iron metabolism].	HEPHL1 HEPH	6.83e-06	3	53	2	24988611
Pubmed	Independent expression of the two paralogous CCL4 genes in monocytes and B lymphocytes.	CCL4L1 CCL4	6.83e-06	3	53	2	14673550
Pubmed	Bone marrow-derived monocyte lineage cells recruited by MIP-1β promote physiological revascularization in mouse model of oxygen-induced retinopathy.	CCL4L1 CCL4	6.83e-06	3	53	2	21912378
Pubmed	Decreased IgG production but increased MIP-1beta expression in collagen-induced arthritis in C-C chemokine receptor 5-deficient mice.	CCL4L1 CCL4	1.36e-05	4	53	2	15967376
Pubmed	Natural truncation of the chemokine MIP-1 beta /CCL4 affects receptor specificity but not anti-HIV-1 activity.	CCL4L1 CCL4	1.36e-05	4	53	2	12070155
Pubmed	Characterization of P4 ATPase Phospholipid Translocases (Flippases) in Human and Rat Pancreatic Beta Cells: THEIR GENE SILENCING INHIBITS INSULIN SECRETION.	ATP8A2 ATP8B2	1.36e-05	4	53	2	26240149
Pubmed	Lumican, an extracellular matrix proteoglycan, is a novel requisite for hepatic fibrosis.	CCL4L1 CCL4	1.36e-05	4	53	2	23007134
Pubmed	A novel polypeptide secreted by activated human T lymphocytes.	CCL4L1 CCL4	1.36e-05	4	53	2	2809212
Pubmed	Rab3 GTPase-activating protein regulates synaptic transmission and plasticity through the inactivation of Rab3.	RAB3GAP1 UNC13A	1.36e-05	4	53	2	16782817
Pubmed	Flt3 signaling involves tyrosyl-phosphorylation of SHP-2 and SHIP and their association with Grb2 and Shc in Baf3/Flt3 cells.	FLT3 SHC1	1.36e-05	4	53	2	10080542
Pubmed	CC-chemokine ligand 4/macrophage inflammatory protein-1β participates in the induction of neuropathic pain after peripheral nerve injury.	CCL4L1 CCL4	1.36e-05	4	53	2	22528550
Pubmed	Essential roles of the interaction between cancer cell-derived chemokine, CCL4, and intra-bone CCR5-expressing fibroblasts in breast cancer bone metastasis.	CCL4L1 CCL4	1.36e-05	4	53	2	27177471
Pubmed	Macrophage inflammatory protein-1β as a novel therapeutic target for renal protection in diabetic kidney disease.	CCL4L1 CCL4	1.36e-05	4	53	2	36863097
Pubmed	Resolution of the two components of macrophage inflammatory protein 1, and cloning and characterization of one of those components, macrophage inflammatory protein 1 beta.	CCL4L1 CCL4	1.36e-05	4	53	2	3058856
Pubmed	Activating transcription factor 3 (ATF3) represses the expression of CCL4 in murine macrophages.	CCL4L1 CCL4	1.36e-05	4	53	2	16982098
Pubmed	Alternatively-Activated Macrophages Upregulate Mesothelial Expression of P-Selectin to Enhance Adhesion of Ovarian Cancer Cells.	CCL4L1 CCL4	1.36e-05	4	53	2	29739756
Pubmed	A biochemical framework for eIF4E-dependent mRNA export and nuclear recycling of the export machinery.	LRPPRC IPO8	1.36e-05	4	53	2	28325843
Pubmed	A novel role of Yin-Yang-1 in pulmonary tuberculosis through the regulation of the chemokine CCL4.	CCL4L1 CCL4	1.36e-05	4	53	2	26786659
Pubmed	Altered thymocyte migration during experimental acute Trypanosoma cruzi infection: combined role of fibronectin and the chemokines CXCL12 and CCL4.	CCL4L1 CCL4	1.36e-05	4	53	2	16637021
Pubmed	Protection from liver fibrosis by a peroxisome proliferator-activated receptor δ agonist.	CCL4L1 CCL4	1.36e-05	4	53	2	22538808
Pubmed	Mitogenic activation of human T cells induces two closely related genes which share structural similarities with a new family of secreted factors.	CCL4L1 CCL4	1.36e-05	4	53	2	2521882
Pubmed	Identification of RANTES, MIP-1 alpha, and MIP-1 beta as the major HIV-suppressive factors produced by CD8+ T cells.	CCL4L1 CCL4	2.27e-05	5	53	2	8525373
Pubmed	WSX-1 signalling inhibits CD4⁺ T cell migration to the liver during malaria infection by repressing chemokine-independent pathways.	CCL4L1 CCL4	2.27e-05	5	53	2	24244314
Pubmed	The CBL-related protein CBLB participates in FLT3 and interleukin-7 receptor signal transduction in pro-B cells.	FLT3 SHC1	2.27e-05	5	53	2	9614102
Pubmed	CCL3L1 and CCL4L1: variable gene copy number in adolescents with and without human immunodeficiency virus type 1 (HIV-1) infection.	CCL4L1 CCL4	2.27e-05	5	53	2	17330138
Pubmed	Hypoxia-induced neutrophil survival is mediated by HIF-1alpha-dependent NF-kappaB activity.	CCL4L1 CCL4	2.27e-05	5	53	2	15630139
Pubmed	Role of dynein, dynactin, and CLIP-170 interactions in LIS1 kinetochore function.	DNAI1 DYNC1H1	2.27e-05	5	53	2	11889140
Pubmed	A novel class of RanGTP binding proteins.	IPO8 IPO7	2.27e-05	5	53	2	9214382
Pubmed	LDL-cholesterol concentrations: a genome-wide association study.	TDRD15 APOB	2.27e-05	5	53	2	18262040
Pubmed	Antagonism of VEGF-A-induced increase in vascular permeability by an integrin α3β1-Shp-1-cAMP/PKA pathway.	ITGA3 CDH5	2.27e-05	5	53	2	23074279
Pubmed	Identification of the CC chemokines TARC and macrophage inflammatory protein-1 beta as novel functional ligands for the CCR8 receptor.	CCL4L1 CCL4	2.27e-05	5	53	2	9521068
Pubmed	The assignment of chemokine-chemokine receptor pairs: TARC and MIP-1 beta are not ligands for human CC-chemokine receptor 8.	CCL4L1 CCL4	2.27e-05	5	53	2	10540332
Pubmed	Role of IL-6 trans-signaling in CCl₄induced liver damage.	CCL4L1 CCL4	2.27e-05	5	53	2	20691261
Pubmed	Chemokine gene expression in the brains of mice with lymphocytic choriomeningitis.	CCL4L1 CCL4	2.27e-05	5	53	2	9311871
Pubmed	Identification of multipotent progenitors in the embryonic mouse kidney by a novel colony-forming assay.	LRP2 ITGA3 CDH5	2.50e-05	37	53	3	16319116
Pubmed	Stasimon/Tmem41b localizes to mitochondria-associated ER membranes and is essential for mouse embryonic development.	LRPPRC IPO8 IPO7 APOB	2.74e-05	113	53	4	30352685
Pubmed	C16orf72/HAPSTR1 is a molecular rheostat in an integrated network of stress response pathways.	LRPPRC IPO8 IPO7 LARP1	3.35e-05	119	53	4	35776542
Pubmed	Dihydro-CDDO-trifluoroethyl amide suppresses inflammatory responses in macrophages via activation of Nrf2.	CCL4L1 CCL4	3.40e-05	6	53	2	24486487
Pubmed	Predictive role of coagulation-balance gene polymorphisms in the efficacy of photodynamic therapy with verteporfin for classic choroidal neovascularization secondary to age-related macular degeneration.	MTR F5	3.40e-05	6	53	2	18004208
Pubmed	Increased responsiveness of murine eosinophils to MIP-1beta (CCL4) and TCA-3 (CCL1) is mediated by their specific receptors, CCR5 and CCR8.	CCL4L1 CCL4	3.40e-05	6	53	2	12050188
Pubmed	Coagulation gene predictors of photodynamic therapy for occult choroidal neovascularization in age-related macular degeneration.	MTR F5	3.40e-05	6	53	2	18378576
Pubmed	CCAAT/enhancer-binding protein homologous (CHOP) protein promotes carcinogenesis in the DEN-induced hepatocellular carcinoma model.	CCL4L1 CCL4	3.40e-05	6	53	2	24339898
Pubmed	Tetraspanin CD81 is linked to ERK/MAPKinase signaling by Shc in liver tumor cells.	SHC1 ITGA3	3.40e-05	6	53	2	14676841
Pubmed	Infiltrating macrophages promote prostate tumorigenesis via modulating androgen receptor-mediated CCL4-STAT3 signaling.	CCL4L1 CCL4	3.40e-05	6	53	2	23878190
Pubmed	FBW7 suppresses ovarian cancer development by targeting the N6-methyladenosine binding protein YTHDF2.	LRPPRC IPO7 RCN1 DYRK1A LARP1 EXOC3 DYNC1H1	3.44e-05	601	53	7	33658012
Pubmed	An improved smaller biotin ligase for BioID proximity labeling.	ATG4A NETO1 LARP1 EIF4G3	3.81e-05	123	53	4	26912792
Pubmed	Signal recognition particle protein 19 is imported into the nucleus by importin 8 (RanBP8) and transportin.	IPO8 IPO7	4.76e-05	7	53	2	11682607
Pubmed	Regulation of chemokines, CCL3 and CCL4, by interferon γ and nitric oxide synthase 2 in mouse macrophages and during Salmonella enterica serovar typhimurium infection.	CCL4L1 CCL4	4.76e-05	7	53	2	23431040
Pubmed	Role of the autocrine chemokines MIP-1alpha and MIP-1beta in the metastatic behavior of murine T cell lymphoma.	CCL4L1 CCL4	4.76e-05	7	53	2	12377948
Pubmed	Bifidobacterium infantis suppression of Peyer's patch MIP-1α and MIP-1β secretion during Salmonella infection correlates with increased local CD4+CD25+ T cell numbers.	CCL4L1 CCL4	4.76e-05	7	53	2	23648818
Pubmed	Two inflammatory mediator cytokine genes are closely linked and variably amplified on chromosome 17q.	CCL4L1 CCL4	4.76e-05	7	53	2	1972563
Pubmed	Heteromeric interactions required for abundance and subcellular localization of human CDC50 proteins and class 1 P4-ATPases.	ATP8A2 ATP8B2	4.76e-05	7	53	2	20947505
Pubmed	Prostaglandin E2 inhibits production of the inflammatory chemokines CCL3 and CCL4 in dendritic cells.	CCL4L1 CCL4	4.76e-05	7	53	2	12960284
Pubmed	Macrophage inflammatory protein-1.	CCL4L1 CCL4	4.76e-05	7	53	2	12401480
Pubmed	Association of signaling proteins with a nonmitogenic heterodimeric complex composed of epidermal growth factor receptor and kinase-inactive p185c-neu.	RAPGEF5 SHC1	4.76e-05	7	53	2	8561895
Pubmed	SHC and SHIP phosphorylation and interaction in response to activation of the FLT3 receptor.	FLT3 SHC1	4.76e-05	7	53	2	10482988
Pubmed	Platelet GPIaC807T polymorphism is associated with negative outcome of sudden hearing loss.	ITGA3 F5	4.76e-05	7	53	2	15109703
Pubmed	MIP-1alpha and MIP-1beta differentially mediate mucosal and systemic adaptive immunity.	CCL4L1 CCL4	4.76e-05	7	53	2	12393512
Pubmed	High dilutions of antimony modulate cytokines production and macrophage - Leishmania (L.) amazonensis interaction in vitro.	CCL4L1 CCL4	4.76e-05	7	53	2	28092793
Pubmed	Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.	IPO7 CHD5 CNKSR2 EIF4G3 DYNC1H1 TP53BP2	4.85e-05	430	53	6	35044719
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	SCN11A LRPPRC CHD5 DNAH2 RCN1 RBM5 LARP1 APOB EIF4G3 ERICH6	5.57e-05	1442	53	10	35575683
Pubmed	Differential expression and regulation of macrophage inflammatory protein (MIP)-1alpha and MIP-2 genes by alveolar and peritoneal macrophages in LPS-hyporesponsive C3H/HeJ mice.	CCL4L1 CCL4	6.34e-05	8	53	2	11069716
Pubmed	Regulatory T cells increase the avidity of primary CD8+ T cell responses and promote memory.	CCL4L1 CCL4	6.34e-05	8	53	2	23112334
Pubmed	27-Hydroxycholesterol and 7alpha-hydroxycholesterol trigger a sequence of events leading to migration of CCR5-expressing Th1 lymphocytes.	CCL4L1 CCL4	6.34e-05	8	53	2	24370436
Pubmed	Regulation of hyaluronan-induced chemokine gene expression by IL-10 and IFN-gamma in mouse macrophages.	CCL4L1 CCL4	6.34e-05	8	53	2	9510207
Pubmed	Importin 8 mediates m7G cap-sensitive nuclear import of the eukaryotic translation initiation factor eIF4E.	IPO8 IPO7	6.34e-05	8	53	2	27114554
Pubmed	Basophils Promote Tumor Rejection via Chemotaxis and Infiltration of CD8+ T Cells.	CCL4L1 CCL4	6.34e-05	8	53	2	27879269
Pubmed	A novel signaling pathway mediates the inhibition of CCL3/4 expression by prostaglandin E2.	CCL4L1 CCL4	6.34e-05	8	53	2	15498767
Pubmed	LINC01554-Mediated Glucose Metabolism Reprogramming Suppresses Tumorigenicity in Hepatocellular Carcinoma via Downregulating PKM2 Expression and Inhibiting Akt/mTOR Signaling Pathway.	LRPPRC IPO7 DNAH2 DYNC1H1	6.68e-05	142	53	4	30809309
Pubmed	Impact of genetic polymorphisms on platelet function and aspirin resistance.	APOB F5	8.15e-05	9	53	2	19923980
Pubmed	Cytotoxic T cells swarm by homotypic chemokine signalling.	CCL4L1 CCL4	8.15e-05	9	53	2	33046212
Pubmed	A family of small inducible proteins secreted by leukocytes are members of a new superfamily that includes leukocyte and fibroblast-derived inflammatory agents, growth factors, and indicators of various activation processes.	CCL4L1 CCL4	8.15e-05	9	53	2	2521353
Pubmed	Expression of Th-1 chemokines and chemokine receptors on the ocular surface of C57BL/6 mice: effects of desiccating stress.	CCL4L1 CCL4	8.15e-05	9	53	2	17525185
Pubmed	Reduced GRK2 level in T cells potentiates chemotaxis and signaling in response to CCL4.	CCL4L1 CCL4	8.15e-05	9	53	2	14761932
Pubmed	Genes associated with antibody-dependent cell activation are overexpressed in renal biopsies from patients with antibody-mediated rejection.	CCL4L1 CCL4	8.15e-05	9	53	2	25449536
Pubmed	Genetic linkage of thymic T-cell proliferative unresponsiveness to mouse chromosome 11 in NOD mice. A possible role for chemokine genes.	CCL4L1 CCL4	8.15e-05	9	53	2	7789623
Pubmed	Fat-storing multilocular cells expressing CCR5 increase in the thymus with advancing age: potential role for CCR5 ligands on the differentiation and migration of preadipocytes.	CCL4L1 CCL4	8.15e-05	9	53	2	20046229
Pubmed	Marked increase in CC chemokine gene expression in both human and mouse mast cell transcriptomes following Fcepsilon receptor I cross-linking: an interspecies comparison.	CCL4L1 CCL4	8.15e-05	9	53	2	12393595
Cytoband	13q12	FLT3 ATP8A2	3.55e-04	24	53	2	13q12
Cytoband	17q21.33	MBTD1 ITGA3	1.04e-03	41	53	2	17q21.33
GeneFamily	ATPase phospholipid transporting	ATP8A2 ATP8B2	4.44e-04	15	38	2	1210
GeneFamily	Dyneins, axonemal	DNAI1 DNAH2	5.73e-04	17	38	2	536
GeneFamily	Armadillo repeat containing\|Importins	IPO8 IPO7	6.44e-04	18	38	2	596
GeneFamily	Chemokine ligands\|Endogenous ligands	CCL4L1 CCL4	4.02e-03	45	38	2	483
Drug	3,8-dihydroxyquinoline	NETO1 APOB	5.32e-06	2	53	2	CID000177338
Drug	B151	NETO1 APOB	5.32e-06	2	53	2	CID000063117
Drug	Cholesterylene	NETO1 APOB	5.32e-06	2	53	2	CID000092835
Drug	Dibucaine [85-79-0]; Up 200; 11.6uM; PC3; HT_HG-U133A	CHD5 DNAH2 APOB OMD UNC13A HEPH	6.74e-06	199	53	6	4068_UP
Drug	virus Tat	NETO1 APOB F5	7.91e-06	17	53	3	CID000071655
Drug	2-oxononanal	NETO1 APOB	1.59e-05	3	53	2	CID000142757
Drug	D05547	NETO1 APOB	1.59e-05	3	53	2	CID010154203
Drug	Tris-Gal-Chol	NETO1 APOB	1.59e-05	3	53	2	CID000174825
Drug	CGS 24565	NETO1 APOB	1.59e-05	3	53	2	CID006443293
Drug	pirozadil	NETO1 APOB	1.59e-05	3	53	2	CID000068711
Drug	2,4,6-trimethylpyrylium	NETO1 APOB	1.59e-05	3	53	2	CID000135854
Drug	CGP 43371	NETO1 APOB	1.59e-05	3	53	2	CID006441203
Drug	copper nitride	NETO1 APOB	1.59e-05	3	53	2	CID000061847
Drug	L-beta-aspartyl phosphate	PTPN5 ATP8A2 EXOC3 ATP8B2	2.02e-05	69	53	4	CID000000832
Drug	hepta-2,4-dienal	NETO1 APOB	3.18e-05	4	53	2	CID000020307
Drug	CL 277082	NETO1 APOB	3.18e-05	4	53	2	CID000125893
Drug	timefurone	NETO1 APOB	3.18e-05	4	53	2	CID000072161
Drug	Sedalipid	NETO1 APOB	5.29e-05	5	53	2	CID000173846
Drug	Advicor	NETO1 APOB	5.29e-05	5	53	2	CID000151176
Drug	Cetyl sulfate	NETO1 APOB	5.29e-05	5	53	2	CID000008911
Drug	Crilvastatine	NETO1 APOB	5.29e-05	5	53	2	CID000060724
Drug	diazinon	DNAI1 NETO1 ATP8A2 DYNC1H1	8.04e-05	98	53	4	CID000003017
Drug	TIBA	DYRK1A MTR DYNC1H1	8.75e-05	37	53	3	CID000006948
Drug	Aminohippuric acid [61-78-9]; Down 200; 20.6uM; MCF7; HT_HG-U133A	MBTD1 IPO8 LRP2 RBM5 DAPK3	9.22e-05	196	53	5	5394_DN
Drug	Nystatine [1400-61-9]; Up 200; 4.4uM; MCF7; HT_HG-U133A	SCN11A IPO8 DAPK3 CAMK1 F5	9.22e-05	196	53	5	4807_UP
Drug	S(+)-Terguride [37686-84-3]; Down 200; 11.8uM; MCF7; HT_HG-U133A	MBTD1 IPO8 LRP2 RBM5 ATP8B2	9.44e-05	197	53	5	5400_DN
Drug	Tridihexethyl chloride; Up 200; 11.4uM; PC3; HT_HG-U133A	RAPGEF5 APOB OMD F5 CDH5	9.67e-05	198	53	5	5067_UP
Drug	Betulinic acid [472-15-1]; Up 200; 8.8uM; PC3; HT_HG-U133A	SCN11A DYRK1A APOB F5 CDH15	9.67e-05	198	53	5	4101_UP
Drug	Tropine [120-29-6]; Up 200; 28.4uM; MCF7; HT_HG-U133A	DFFB SCN11A RBM5 DAPK3 CDH5	1.01e-04	200	53	5	6264_UP
Drug	PSA11-SPM	NETO1 APOB	1.11e-04	7	53	2	CID006439362
Drug	N-ethylmorpholine	NETO1 APOB	1.11e-04	7	53	2	CID000007525
Drug	phthalic acid	NETO1 DYRK1A APOB TP53BP2	1.21e-04	109	53	4	CID000001017
Drug	LGE2	NETO1 APOB	1.48e-04	8	53	2	CID005771742
Drug	iodoquinol	DAPK3 DYNC1H1	1.48e-04	8	53	2	CID000003728
Drug	CP-113,818	NETO1 APOB	1.48e-04	8	53	2	CID000164373
Drug	cholesteryl linoleyl ether	NETO1 APOB	1.48e-04	8	53	2	CID006438363
Drug	S 422	NETO1 APOB	1.48e-04	8	53	2	CID000035748
Drug	4-hydroxyoctenal	NETO1 APOB	1.89e-04	9	53	2	CID005283334
Drug	pentol	NETO1 APOB	1.89e-04	9	53	2	CID006436590
Drug	SureCN3420785	PTPN5 EXOC3	1.89e-04	9	53	2	CID011291331
Disease	proprotein convertase subtilisin/kexin type 9 measurement	TDRD15 APOB CNKSR2	7.76e-06	22	52	3	EFO_0009312
Disease	R-6-hydroxywarfarin measurement	FLT3 NETO1 DNAH2 MTR	4.96e-05	114	52	4	EFO_0803327
Disease	esterified cholesterol measurement, intermediate density lipoprotein measurement	TDRD15 APOB	8.47e-05	8	52	2	EFO_0008589, EFO_0008595
Disease	epilepsy (implicated_via_orthology)	SCN11A ITGA3 UNC13A DYNC1H1	1.98e-04	163	52	4	DOID:1826 (implicated_via_orthology)
Disease	Colorectal Carcinoma	CHD5 RCN1 LRP2 APOB CNKSR2 F5 CDH5	2.21e-04	702	52	7	C0009402
Disease	common carotid intimal medial thickness	TDRD15 ATP8A2 APOB	2.28e-04	67	52	3	EFO_0004860
Disease	esterified cholesterol measurement, low density lipoprotein cholesterol measurement	TDRD15 APOB	2.73e-04	14	52	2	EFO_0004611, EFO_0008589
Disease	low density lipoprotein triglyceride measurement	TDRD15 APOB	3.15e-04	15	52	2	EFO_0009946
Disease	response to statin, LDL cholesterol change measurement	TDRD15 APOB	3.15e-04	15	52	2	EFO_0007804, GO_0036273
Disease	HMG CoA reductase inhibitor use measurement	TDRD15 LRPPRC APOB HERC3	3.47e-04	189	52	4	EFO_0009932
Disease	cholesterol to total lipids in chylomicrons and extremely large VLDL percentage	TDRD15 APOB	4.07e-04	17	52	2	EFO_0022232
Disease	very low density lipoprotein cholesterol measurement, esterified cholesterol measurement	TDRD15 APOB	4.58e-04	18	52	2	EFO_0008317, EFO_0008589
Disease	low density lipoprotein cholesterol measurement, alcohol consumption measurement	TDRD15 RAB3GAP1 APOB	7.19e-04	99	52	3	EFO_0004611, EFO_0007878
Disease	low density lipoprotein cholesterol measurement, alcohol drinking	TDRD15 RAB3GAP1 APOB	7.84e-04	102	52	3	EFO_0004329, EFO_0004611
Disease	level of Sterol ester (27:1/18:2) in blood serum	TDRD15 APOB	9.64e-04	26	52	2	OBA_2045194
Disease	cholesterol to total lipids in medium LDL percentage	TDRD15 APOB	1.04e-03	27	52	2	EFO_0022238
Disease	anti-basement membrane glomerulonephritis (biomarker_via_orthology)	CCL4L1 CCL4	1.28e-03	30	52	2	DOID:4780 (biomarker_via_orthology)
Disease	triacylglycerol 54:3 measurement	CACNA2D4 ATP8A2	1.37e-03	31	52	2	EFO_0010421
Disease	pack-years measurement, systolic blood pressure	CACNA2D4 LRP2	1.65e-03	34	52	2	EFO_0006335, EFO_0006526

Protein segments in the cluster

Peptide	Gene	Start	Entry
GDDAWKVYYDETAQE	UNC13A	846	Q9UPW8
EYLWKVTDIGDYDDD	ERICH6	76	Q7L0X2
TDYLEEYPDTDELVW	ATG4A	16	Q8WYN0
QCTWEIDDIDIPYYD	CHD5	621	Q8TDI0
RAIPDDDLEKYWDFY	ASB4	356	Q9Y574
IKEQDGREVDWEYFY	DFFB	276	O76075
NQWEIYDAYVEELEK	DNAI1	226	Q9UI46
DDDNYDYIVKNGEKW	DYRK1A	141	Q13627
DIYNEKELDREVYPW	CDH5	426	P33151
VIYALWDYEPQNDDE	TP53BP2	1061	Q13625
YADLSENEYEEWLKV	ATP8A2	631	Q9NTI2
ENEYEEWLKVYQEAS	ATP8A2	636	Q9NTI2
VLAYKDLDEEYYEEW	ATP8B2	616	P98198
DYDRDKDDKISWEEY	RCN1	126	Q15293
WYSPRDYIEEEVIDE	RAB3GAP1	701	Q15042
ELYFDEKYSIEPSWE	NETO1	81	Q8TDF5
GPELSDWEKYAAEEY	PPP2R3B	496	Q9Y5P8
DWEKYAAEEYDILVA	PPP2R3B	501	Q9Y5P8
EKCTEYWPEEQVAYD	PTPN5	406	P54829
YEQDLWAEKFEPEYS	LARP1	686	Q6PKG0
EEYDQWVDCESPDLY	MBTD1	531	Q05BQ5
WVESEYLDYLFEVEP	IFNLR1	111	Q8IU57
YEEDENWPEIFVKVY	INTS1	216	Q8N201
NWEELEETAIYKGDY	HERC3	941	Q15034
DPSESWVQEYVYDLE	CCL4	76	P13236
EWDLSEYSYKDPEDQ	ITGA3	231	P26006
TDADEELWQEDPYEY	IPO7	361	O95373
LAAIYEEKEAWYREE	DAPK3	356	O43293
EVPFDVPELWYEDEK	LRPPRC	1006	P42704
DDAEQYIYWVENPGE	LRP2	1786	P98164
EEYIQAVDYDWDPKD	LRP2	4081	P98164
LYWDGEKETYVPAAE	RBM5	496	P52756
LKAEYEFDSPYWDDI	CAMK1	231	Q14012
EYEYDLKWEFPRENL	FLT3	596	P36888
AEYEEDGKYEGLQEW	APOB	3956	P04114
DPSESWVQEYVYDLE	CCL4L1	76	Q8NHW4
GAVEDYEPVFEKYNW	CACNA2D4	406	Q7Z3S7
YIAAEEVEWDYAPNK	HEPHL1	736	Q6MZM0
PYYKVFEEDALSWED	DYNC1H1	1511	Q14204
DNEVYLPNDEIWTYD	KLHDC1	36	Q8N7A1
WVKETEPEADQDGYY	EXOC3	406	O60645
DEYEETPWDALKYLI	DNAH2	4026	Q9P225
SYSKDYDPEDWLQVD	CDH15	411	P55291
YDEEVISEDAFYKWE	EIF4G3	1536	O43432
QWDEDYDQEPDDDYQ	OMD	26	Q99983
YKDEDEELWQEDPYE	IPO8	361	O15397
DEEVQKEFEDFWEYY	MCM9	281	Q9NXL9
NEPDEIWDDKTVDYF	TDRD15	1416	B5MCY1
EYFIAAEEVIWDYAP	F5	351	P12259
YKDDSYTDEVAQPAW	HEPH	81	Q9BQS7
FEDYDLQKLVDYIDW	MTR	961	Q99707
YFKYIDEEDEDDEWS	RAPGEF5	36	Q92565
ASLYWYINEEDEKAE	CNKSR2	601	Q8WXI2
ENFVYPWYRDVTDDE	SNX14	146	Q9Y5W7
DDFDIFYEVWEKFDP	SCN11A	1621	Q9UI33
AWDEEEEEPPDHQYY	SHC1	336	P29353