Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	molecular adaptor activity	SHANK1 COL4A2 COL4A4 BCL9L ZSWIM8 RIPK3 ARID3A PPRC1 NACA POU2AF1 TAB2 SUPT20HL2 ATG2A KMT2E MIDEAS G3BP1 HGS SHARPIN SYN1 EIF3B BRD1 HYAL2 TNS3	3.79e-05	1356	135	23	GO:0060090
GeneOntologyMolecularFunction	extracellular matrix structural constituent	COL4A2 COL4A4 COL4A5 NID2 EFEMP2 ENAM ACAN NPNT	4.25e-05	188	135	8	GO:0005201
GeneOntologyMolecularFunction	phosphatase regulator activity	LMTK2 PPP6R1 ZEB2 PPP1R10 DMPK CABIN1	1.19e-04	113	135	6	GO:0019208
GeneOntologyMolecularFunction	protein-macromolecule adaptor activity	SHANK1 BCL9L ZSWIM8 RIPK3 ARID3A PPRC1 NACA POU2AF1 SUPT20HL2 ATG2A KMT2E MIDEAS G3BP1 HGS SHARPIN SYN1 BRD1 HYAL2 TNS3	3.01e-04	1160	135	19	GO:0030674
GeneOntologyMolecularFunction	protein phosphatase regulator activity	LMTK2 PPP6R1 PPP1R10 DMPK CABIN1	5.90e-04	100	135	5	GO:0019888
GeneOntologyCellularComponent	basement membrane	COL4A2 COL4A4 COL4A5 NID2 LAMB4 EFEMP2 LOXL1 ACAN NPNT	1.26e-07	122	139	9	GO:0005604
GeneOntologyCellularComponent	collagen type IV trimer	COL4A2 COL4A4 COL4A5	5.67e-06	6	139	3	GO:0005587
GeneOntologyCellularComponent	basement membrane collagen trimer	COL4A2 COL4A4 COL4A5	1.57e-05	8	139	3	GO:0098651
GeneOntologyCellularComponent	network-forming collagen trimer	COL4A2 COL4A4 COL4A5	1.57e-05	8	139	3	GO:0098642
GeneOntologyCellularComponent	collagen network	COL4A2 COL4A4 COL4A5	1.57e-05	8	139	3	GO:0098645
GeneOntologyCellularComponent	complex of collagen trimers	COL4A2 COL4A4 COL4A5	3.51e-04	21	139	3	GO:0098644
Domain	LRRC37AB_C	LRRC37A3 LRRC37A2 LRRC37A	1.54e-06	4	137	3	IPR029423
Domain	LRRC37AB_C	LRRC37A3 LRRC37A2 LRRC37A	1.54e-06	4	137	3	PF14914
Domain	LRRC37_N	LRRC37A3 LRRC37A2 LRRC37A	1.54e-06	4	137	3	IPR032754
Domain	LRRC37	LRRC37A3 LRRC37A2 LRRC37A	1.54e-06	4	137	3	PF15779
Domain	LRRC37A/B-like	LRRC37A3 LRRC37A2 LRRC37A	1.54e-06	4	137	3	IPR015753
Domain	C4	COL4A2 COL4A4 COL4A5	7.60e-06	6	137	3	SM00111
Domain	Collagen_VI_NC	COL4A2 COL4A4 COL4A5	7.60e-06	6	137	3	IPR001442
Domain	NC1_IV	COL4A2 COL4A4 COL4A5	7.60e-06	6	137	3	PS51403
Domain	-	COL4A2 COL4A4 COL4A5	7.60e-06	6	137	3	2.170.240.10
Domain	C4	COL4A2 COL4A4 COL4A5	7.60e-06	6	137	3	PF01413
Domain	Znf_FYVE_PHD	SPIRE2 ZBTB4 PHRF1 KMT2E HGS BRD1 BSN	1.06e-04	147	137	7	IPR011011
Domain	-	ZC3H6 PPP1R10 MBNL2 RBM27	2.06e-04	40	137	4	4.10.1000.10
Domain	WWE	DTX4 DTX2	3.17e-04	4	137	2	SM00678
Domain	WWE-dom_subgr	DTX4 DTX2	3.17e-04	4	137	2	IPR018123
Domain	zf-CCCH	ZC3H6 PPP1R10 MBNL2 RBM27	4.54e-04	49	137	4	PF00642
Domain	VWA_2	INTS6L INTS6	5.26e-04	5	137	2	PF13519
Domain	EGF-like_CS	NID2 LAMB4 EFEMP2 CELSR3 ADAM33 LTBP3 HYAL2 NPNT	6.92e-04	261	137	8	IPR013032
Domain	EGF_2	NID2 LAMB4 EFEMP2 CELSR3 ADAM33 LTBP3 HYAL2 NPNT	7.64e-04	265	137	8	PS01186
Domain	ASX_HYDROXYL	NID2 EFEMP2 CELSR3 LTBP3 NPNT	8.51e-04	100	137	5	PS00010
Domain	Znf_CCCH	ZC3H6 PPP1R10 MBNL2 RBM27	8.65e-04	58	137	4	IPR000571
Domain	ZF_C3H1	ZC3H6 PPP1R10 MBNL2 RBM27	8.65e-04	58	137	4	PS50103
Domain	cEGF	NID2 EFEMP2 LTBP3	8.87e-04	26	137	3	PF12662
Domain	cEGF	NID2 EFEMP2 LTBP3	8.87e-04	26	137	3	IPR026823
Domain	EGF-type_Asp/Asn_hydroxyl_site	NID2 EFEMP2 CELSR3 LTBP3 NPNT	1.11e-03	106	137	5	IPR000152
Domain	INT_SG_DDX_CT_C	INTS6L INTS6	1.45e-03	8	137	2	PF15300
Domain	INT_SG_DDX_CT_C	INTS6L INTS6	1.45e-03	8	137	2	IPR029307
Pathway	BIOCARTA_VITCB_PATHWAY	COL4A2 COL4A4 COL4A5 SLC23A1	4.95e-07	11	90	4	M15422
Pathway	BIOCARTA_VITCB_PATHWAY	COL4A2 COL4A4 COL4A5 SLC23A1	7.39e-07	12	90	4	MM1526
Pathway	REACTOME_LAMININ_INTERACTIONS	COL4A2 COL4A4 COL4A5 NID2	2.01e-06	15	90	4	MM14922
Pathway	REACTOME_CROSSLINKING_OF_COLLAGEN_FIBRILS	COL4A2 COL4A4 COL4A5 LOXL1	4.44e-06	18	90	4	M27164
Pathway	REACTOME_CROSSLINKING_OF_COLLAGEN_FIBRILS	COL4A2 COL4A4 COL4A5 LOXL1	4.44e-06	18	90	4	MM14882
Pathway	BIOCARTA_NPP1_PATHWAY	COL4A2 COL4A4 COL4A5	2.92e-05	10	90	3	M22040
Pathway	BIOCARTA_NPP1_PATHWAY	COL4A2 COL4A4 COL4A5	2.92e-05	10	90	3	MM1560
Pathway	REACTOME_SIGNALING_BY_PDGF	COL4A2 COL4A4 COL4A5 RAPGEF1 BCAR1	3.06e-05	57	90	5	MM14713
Pathway	REACTOME_SIGNALING_BY_PDGF	COL4A2 COL4A4 COL4A5 RAPGEF1 BCAR1	3.33e-05	58	90	5	M2049
Pathway	REACTOME_LAMININ_INTERACTIONS	COL4A2 COL4A4 COL4A5 NID2	3.75e-05	30	90	4	M27216
Pathway	REACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION	COL4A2 COL4A4 COL4A5 NID2 EFEMP2 LOXL1 ACAN LTBP3 ADAMTS14	3.89e-05	258	90	9	MM14572
Pathway	BIOCARTA_ACE2_PATHWAY	COL4A2 COL4A4 COL4A5	6.87e-05	13	90	3	MM1347
Pathway	BIOCARTA_ACE2_PATHWAY	COL4A2 COL4A4 COL4A5	6.87e-05	13	90	3	M12950
Pathway	BIOCARTA_PLATELETAPP_PATHWAY	COL4A2 COL4A4 COL4A5	8.71e-05	14	90	3	MM1458
Pathway	BIOCARTA_PLATELETAPP_PATHWAY	COL4A2 COL4A4 COL4A5	8.71e-05	14	90	3	M6487
Pathway	REACTOME_ANCHORING_FIBRIL_FORMATION	COL4A2 COL4A4 COL4A5	1.08e-04	15	90	3	M27161
Pathway	REACTOME_COLLAGEN_FORMATION	COL4A2 COL4A4 COL4A5 LOXL1 ADAMTS14	1.23e-04	76	90	5	MM14573
Pathway	REACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION	COL4A2 COL4A4 COL4A5 NID2 EFEMP2 LOXL1 ACAN LTBP3 ADAMTS14	1.24e-04	300	90	9	M610
Pathway	PID_MET_PATHWAY	PAK4 RAPGEF1 BCAR1 MAP3K1 HGS	1.47e-04	79	90	5	M48
Pathway	BIOCARTA_AMI_PATHWAY	COL4A2 COL4A4 COL4A5	2.65e-04	20	90	3	M15394
Pathway	REACTOME_NCAM1_INTERACTIONS	COL4A2 COL4A4 COL4A5	2.65e-04	20	90	3	MM15061
Pathway	REACTOME_COLLAGEN_FORMATION	COL4A2 COL4A4 COL4A5 LOXL1 ADAMTS14	2.72e-04	90	90	5	M631
Pathway	REACTOME_ASSEMBLY_OF_COLLAGEN_FIBRILS_AND_OTHER_MULTIMERIC_STRUCTURES	COL4A2 COL4A4 COL4A5 LOXL1	2.86e-04	50	90	4	MM14796
Pathway	BIOCARTA_INTRINSIC_PATHWAY	COL4A2 COL4A4 COL4A5	4.06e-04	23	90	3	M15997
Pathway	BIOCARTA_INTRINSIC_PATHWAY	COL4A2 COL4A4 COL4A5	4.06e-04	23	90	3	MM1427
Pathway	REACTOME_SIGNALING_BY_RECEPTOR_TYROSINE_KINASES	COL4A2 COL4A4 COL4A5 ERBB3 RAPGEF1 FGFRL1 TAB2 BCAR1 PGR HGS TNS3	5.58e-04	532	90	11	M27870
Pathway	REACTOME_ASSEMBLY_OF_COLLAGEN_FIBRILS_AND_OTHER_MULTIMERIC_STRUCTURES	COL4A2 COL4A4 COL4A5 LOXL1	6.14e-04	61	90	4	M27103
Pathway	REACTOME_COLLAGEN_BIOSYNTHESIS_AND_MODIFYING_ENZYMES	COL4A2 COL4A4 COL4A5 ADAMTS14	6.14e-04	61	90	4	MM14637
Pathway	REACTOME_COLLAGEN_BIOSYNTHESIS_AND_MODIFYING_ENZYMES	COL4A2 COL4A4 COL4A5 ADAMTS14	8.76e-04	67	90	4	M26999
Pathway	REACTOME_NON_INTEGRIN_MEMBRANE_ECM_INTERACTIONS	COL4A2 COL4A4 COL4A5	1.09e-03	32	90	3	MM14924
Pathway	REACTOME_SIGNALING_BY_RECEPTOR_TYROSINE_KINASES	COL4A2 COL4A4 COL4A5 ERBB3 RAPGEF1 FGFRL1 BCAR1 HGS TNS3	1.38e-03	418	90	9	MM15587
Pathway	REACTOME_ECM_PROTEOGLYCANS	COL4A2 COL4A4 COL4A5 ACAN	1.40e-03	76	90	4	M27219
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	COL4A5 SPIRE2 ARID3A EP400 PPRC1 ESYT1 ZBTB4 OBSCN ADGRB2 FBRSL1 LMTK2 RAPGEF1 FGFRL1 PPP6R1 ATG2A IFNLR1 PHC2 MDN1 CELSR3 TMEM259 MCM3AP PLA2G6 LTBP3 DTX2 CABIN1 AHNAK2	6.96e-13	1105	144	26	35748872
Pubmed	Compound genetic ablation of nidogen 1 and 2 causes basement membrane defects and perinatal lethality in mice.	COL4A2 COL4A4 COL4A5 NID2	1.36e-07	12	144	4	16024816
Pubmed	Primate segmental duplication creates novel promoters for the LRRC37 gene family within the 17q21.31 inversion polymorphism region.	LRRC37A3 LRRC37A2 LRRC37A	2.77e-07	4	144	3	22419166
Pubmed	Identification of a novel cell-adhesive protein spatiotemporally expressed in the basement membrane of mouse developing hair follicle.	COL4A2 COL4A4 COL4A5 NID2	4.93e-07	16	144	4	15878328
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	NID2 ZSWIM8 PSD EP400 POLD1 PHRF1 FBRSL1 PPP6R1 NCKAP5L TUBGCP6 INTS6 GSE1 ATXN7 GLI3 MCM3AP BRD1 SEZ6L LRRC41	9.20e-07	1116	144	18	31753913
Pubmed	Extracellular matrix of the human optic nerve head.	COL4A2 COL4A4 COL4A5	1.38e-06	6	144	3	2426947
Pubmed	Insertional mutation of the collagen genes Col4a3 and Col4a4 in a mouse model of Alport syndrome.	COL4A2 COL4A4 COL4A5	1.38e-06	6	144	3	10534397
Pubmed	Developmental distribution of collagen IV isoforms and relevance to ocular diseases.	COL4A2 COL4A4 COL4A5	1.38e-06	6	144	3	19275937
Pubmed	Distribution of basement membrane proteins in normal and fibrotic human liver: collagen type IV, laminin, and fibronectin.	COL4A2 COL4A4 COL4A5	1.38e-06	6	144	3	6988303
Pubmed	Stimulation of extracellular matrix components in the normal brain by invading glioma cells.	COL4A2 COL4A4 COL4A5	1.38e-06	6	144	3	9506531
Pubmed	HIV-1 gp160 protein-macrophage interactions modulate mesangial cell proliferation and matrix synthesis.	COL4A2 COL4A4 COL4A5	1.38e-06	6	144	3	7495302
Pubmed	Angiogenesis and collagen type IV expression in different endothelial cell culture systems.	COL4A2 COL4A4 COL4A5	1.38e-06	6	144	3	23551189
Pubmed	Monoclonal antibody to human basement membrane collagen type IV.	COL4A2 COL4A4 COL4A5	1.38e-06	6	144	3	6811420
Pubmed	Immunolocalization of collagen types, laminin and fibronectin in the normal human pancreas.	COL4A2 COL4A4 COL4A5	1.38e-06	6	144	3	6389236
Pubmed	Collagen IV in the developing lens capsule.	COL4A2 COL4A4 COL4A5	1.38e-06	6	144	3	12225806
Pubmed	A tumor derived motility factor that stimulates cell migration on extracellular matrix.	COL4A2 COL4A4 COL4A5	1.38e-06	6	144	3	9673377
Pubmed	Localization of type IV collagen a 1 to a 6 chains in basement membrane during mouse molar germ development.	COL4A2 COL4A4 COL4A5	1.38e-06	6	144	3	11732842
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	EP400 PAK4 NACA PHRF1 FBRSL1 LMTK2 ATG2A TUBGCP6 MAST4 CELSR3 RBM27 BSN	2.28e-06	529	144	12	14621295
Pubmed	Regulation of protease nexin-1 target protease specificity by collagen type IV.	COL4A2 COL4A4 COL4A5	2.40e-06	7	144	3	8006028
Pubmed	Corneal cell proteins and ocular surface pathology.	COL4A2 COL4A4 COL4A5	2.40e-06	7	144	3	10416788
Pubmed	Hypoplastic basement membrane of the lens anlage in the inheritable lens aplastic mouse (lap mouse).	COL4A2 COL4A4 COL4A5	2.40e-06	7	144	3	10716744
Pubmed	Complex patterns of expression suggest extensive roles for the alpha 2 beta 1 integrin in murine development.	COL4A2 COL4A4 COL4A5	2.40e-06	7	144	3	7521231
Pubmed	Nidogen-1. Expression and ultrastructural localization during the onset of mesoderm formation in the early mouse embryo.	COL4A2 COL4A4 COL4A5	2.40e-06	7	144	3	10639489
Pubmed	Interstitial collagens I, III, and VI sequester and modulate the multifunctional cytokine oncostatin M.	COL4A2 COL4A4 COL4A5	2.40e-06	7	144	3	11711546
Pubmed	Purification, partial characterization of rat kidney hyaluronic acid binding protein and its localization on the cell surface.	COL4A2 COL4A4 COL4A5	2.40e-06	7	144	3	1724753
Pubmed	Functional consequence of fibulin-4 missense mutations associated with vascular and skeletal abnormalities and cutis laxa.	EFEMP2 LOXL1 LTBP3	3.83e-06	8	144	3	27339457
Pubmed	Appearance and persistence of fibronectin in cartilage. Specific interaction of fibronectin with collagen type II.	COL4A2 COL4A4 COL4A5	3.83e-06	8	144	3	3997552
Pubmed	Type IV collagen α6 chain is a regulator of keratin 10 in keratinization of oral mucosal epithelium.	COL4A2 COL4A4 COL4A5	3.83e-06	8	144	3	29422532
Pubmed	Transforming growth factor-beta and p-21: multiple molecular targets of decorin-mediated suppression of neoplastic growth.	COL4A2 COL4A4 COL4A5	3.83e-06	8	144	3	10382266
Pubmed	Differential gene expression during capillary morphogenesis in 3D collagen matrices: regulated expression of genes involved in basement membrane matrix assembly, cell cycle progression, cellular differentiation and G-protein signaling.	COL4A2 COL4A4 COL4A5	3.83e-06	8	144	3	11683410
Pubmed	Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.	LRRC37A3 PPRC1 ZEB2 LRRC37A MCM3AP PACS2	5.21e-06	105	144	6	9628581
Pubmed	Developmental changes in seminiferous tubule extracellular matrix components of the mouse testis: alpha 3(IV) collagen chain expressed at the initiation of spermatogenesis.	COL4A2 COL4A4 COL4A5	5.73e-06	9	144	3	8562707
Pubmed	Krüppel-like zinc-finger transcription factor KLF5/BTEB2 is a target for angiotensin II signaling and an essential regulator of cardiovascular remodeling.	COL4A2 COL4A4 COL4A5	5.73e-06	9	144	3	12101409
Pubmed	MMP-9 from TNF alpha-stimulated keratinocytes binds to cell membranes and type I collagen: a cause for extended matrix degradation in inflammation?	COL4A2 COL4A4 COL4A5	5.73e-06	9	144	3	9878537
Pubmed	TBK1 and IKKε prevent TNF-induced cell death by RIPK1 phosphorylation.	RIPK3 TNIP2 TAB2 SHARPIN	7.10e-06	30	144	4	30420664
Pubmed	Human transcription factor protein interaction networks.	BCL9L ARID3A EP400 TNIP2 NACA FBRSL1 ETV5 PPP6R1 MIDEAS ZEB2 GSE1 G3BP1 RBM27 ATXN7 FUBP1 GLI3 HGS EIF3B CABIN1	7.48e-06	1429	144	19	35140242
Pubmed	Evolutionary dynamism of the primate LRRC37 gene family.	LRRC37A3 LRRC37A2 LRRC37A	8.17e-06	10	144	3	23064749
Pubmed	Distribution of fibronectin, type I collagen, type IV collagen, and laminin in the cardiac jelly of the mouse embryonic heart with retinoic acid-induced complete transposition of the great arteries.	COL4A2 COL4A4 COL4A5	8.17e-06	10	144	3	9415455
Pubmed	Interaction between Alzheimer's disease beta A4 precursor protein (APP) and the extracellular matrix: evidence for the participation of heparan sulfate proteoglycans.	COL4A2 COL4A4 COL4A5	8.17e-06	10	144	3	9136074
Pubmed	Binding of mouse and human fibulin-2 to extracellular matrix ligands.	COL4A2 COL4A4 COL4A5	1.12e-05	11	144	3	7500359
Pubmed	Collagen IV is essential for basement membrane stability but dispensable for initiation of its assembly during early development.	COL4A2 COL4A4 COL4A5	1.12e-05	11	144	3	14998921
Pubmed	Sensory ataxia and muscle spindle agenesis in mice lacking the transcription factor Egr3.	COL4A2 COL4A4 COL4A5	1.12e-05	11	144	3	9731539
Pubmed	Muscle progenitor cells failing to respond to positional cues adopt non-myogenic fates in myf-5 null mice.	COL4A2 COL4A4 COL4A5	1.49e-05	12	144	3	8918877
Pubmed	Basement membrane fragility underlies embryonic lethality in fukutin-null mice.	COL4A2 COL4A4 COL4A5	1.49e-05	12	144	3	15837576
Pubmed	Urogenital development in Pallister-Hall syndrome is disrupted in a cell-lineage-specific manner by constitutive expression of GLI3 repressor.	ETV5 GLI3 SIX2	1.49e-05	12	144	3	26604140
Pubmed	Matrilin-2 interacts with itself and with other extracellular matrix proteins.	COL4A2 COL4A4 COL4A5	1.49e-05	12	144	3	12180907
Pubmed	The clinical spectrum of type IV collagen mutations.	COL4A4 COL4A5	1.70e-05	2	144	2	9195222
Pubmed	Structures of collagen IV globular domains: insight into associated pathologies, folding and network assembly.	COL4A2 COL4A4	1.70e-05	2	144	2	30443360
Pubmed	Frequent COL4 mutations in familial microhematuria accompanied by later-onset Alport nephropathy due to focal segmental glomerulosclerosis.	COL4A4 COL4A5	1.70e-05	2	144	2	28632965
Pubmed	[Collagen alpha5 and alpha2 (IV) chain coexpression: The procedure of choice to diagnose Alport syndrome from skin biopsies].	COL4A2 COL4A5	1.70e-05	2	144	2	18706356
Pubmed	Direct binding of p130(Cas) to the guanine nucleotide exchange factor C3G.	RAPGEF1 BCAR1	1.70e-05	2	144	2	9748234
Pubmed	Sharpin, a novel postsynaptic density protein that directly interacts with the shank family of proteins.	SHANK1 SHARPIN	1.70e-05	2	144	2	11178875
Pubmed	Glomerular expression of alpha2(IV) and alpha5(IV) chains of type IV collagen in patients with IgA nephropathy.	COL4A2 COL4A5	1.70e-05	2	144	2	12021518
Pubmed	Collagen alpha5 and alpha2(IV) chain coexpression: analysis of skin biopsies of Alport patients.	COL4A2 COL4A5	1.70e-05	2	144	2	17554254
Pubmed	Modification of an aggressive model of Alport Syndrome reveals early differences in disease pathogenesis due to genetic background.	COL4A4 COL4A5	1.70e-05	2	144	2	31892712
Pubmed	Basal lamina molecules are concentrated in myogenic regions of the mouse limb bud.	COL4A2 COL4A4 COL4A5	1.93e-05	13	144	3	9833687
Pubmed	Transcriptome-based systematic identification of extracellular matrix proteins.	COL4A2 COL4A4 COL4A5 NID2 NPNT	2.00e-05	79	144	5	18757743
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	EP400 SAMD4B PHRF1 USP19 PHC2 TUBGCP6 MDN1 GSE1 G3BP1 ATXN7 FUBP1 PACS2 EIF3B	2.16e-05	774	144	13	15302935
Pubmed	Abnormal expression of collagen IV in lens activates unfolded protein response resulting in cataract.	COL4A2 COL4A4 COL4A5	2.45e-05	14	144	3	19858219
Pubmed	Neural crest-specific removal of Zfhx1b in mouse leads to a wide range of neurocristopathies reminiscent of Mowat-Wilson syndrome.	ERBB3 PNMT ZEB2	2.45e-05	14	144	3	17478475
Pubmed	Characterization of the enzymatic activity of human kallikrein 6: Autoactivation, substrate specificity, and regulation by inhibitors.	COL4A2 COL4A4 COL4A5	2.45e-05	14	144	3	12878203
Pubmed	The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells.	ARID3A EP400 SAMD4B PPP6R1 ZEB2 PHC2 MDN1 GLI3	2.46e-05	282	144	8	23667531
Pubmed	Defective glomerulogenesis in the absence of laminin alpha5 demonstrates a developmental role for the kidney glomerular basement membrane.	COL4A2 COL4A4 COL4A5	3.05e-05	15	144	3	10625553
Pubmed	Localization of basement membrane-associated protein isoforms during development of the ocular surface of mouse eye.	COL4A2 COL4A4 COL4A5	3.05e-05	15	144	3	9264260
Pubmed	Inhibition of distal lung morphogenesis in Nkx2.1(-/-) embryos.	COL4A2 COL4A4 COL4A5	3.05e-05	15	144	3	10706142
Pubmed	A human MAP kinase interactome.	SHANK1 INTS6L ZNF142 PAK4 RAPGEF1 NCKAP5L MIDEAS MCM3AP HGS ANKRD24	3.75e-05	486	144	10	20936779
Pubmed	The variant Polycomb Repressor Complex 1 component PCGF1 interacts with a pluripotency sub-network that includes DPPA4, a regulator of embryogenesis.	ERBB3 CHERP ARID3A EP400 SAMD4B NACA PHC2 RBM27 LRRC41	4.32e-05	396	144	9	26687479
Pubmed	Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.	INTS6L COL4A2 ASB16-AS1 CTTNBP2 CHERP OBSCN RAPGEF1 BCAR1 NCKAP5L IFNLR1 TUBGCP6 SMYD4 FUBP1 SHARPIN ANKRD24 ADAMTS14	4.64e-05	1215	144	16	15146197
Pubmed	Collagen IV diseases: A focus on the glomerular basement membrane in Alport syndrome.	COL4A4 COL4A5	5.09e-05	3	144	2	27576055
Pubmed	A mouse Col4a4 mutation causing Alport glomerulosclerosis with abnormal collagen α3α4α5(IV) trimers.	COL4A4 COL4A5	5.09e-05	3	144	2	24522496
Pubmed	Collagen IV alpha 3, alpha 4, and alpha 5 chains in rodent basal laminae: sequence, distribution, association with laminins, and developmental switches.	COL4A4 COL4A5	5.09e-05	3	144	2	7962065
Pubmed	Autosomal dominant form of type IV collagen nephropathy exists among patients with hereditary nephritis difficult to diagnose clinicopathologically.	COL4A4 COL4A5	5.09e-05	3	144	2	28704582
Pubmed	Integration of Genetic Testing and Pathology for the Diagnosis of Adults with FSGS.	COL4A4 COL4A5	5.09e-05	3	144	2	30647093
Pubmed	Integrated bioinformatics analysis reveals novel key biomarkers and potential candidate small molecule drugs in gastric cancer.	COL4A2 NID2	5.09e-05	3	144	2	30975489
Pubmed	Genetic Variants of the COL4A3 , COL4A4 , and COL4A5 Genes Contribute to Thinned Glomerular Basement Membrane Lesions in Sporadic IgA Nephropathy Patients.	COL4A4 COL4A5	5.09e-05	3	144	2	36130833
Pubmed	Genetic diagnosis of Alport syndrome in 16 Chinese families.	COL4A4 COL4A5	5.09e-05	3	144	2	38433557
Pubmed	Selective inhibition of progesterone receptor in osteochondral progenitor cells, but not in mature chondrocytes, modulated subchondral bone structures.	PGR ACAN	5.09e-05	3	144	2	31863959
Pubmed	T cells develop normally in the absence of both Deltex1 and Deltex2.	DTX4 DTX2	5.09e-05	3	144	2	16923970
Pubmed	Sense and Antisense DMPK RNA Foci Accumulate in DM1 Tissues during Development.	MBNL2 DMPK	5.09e-05	3	144	2	26339785
Pubmed	Characterization of assembly of recombinant type IV collagen alpha3, alpha4, and alpha5 chains in transfected cell strains.	COL4A4 COL4A5	5.09e-05	3	144	2	14633121
Pubmed	Novel COL4A5, COL4A4, and COL4A3 mutations in Alport syndrome.	COL4A4 COL4A5	5.09e-05	3	144	2	15954103
Pubmed	Alport syndrome: impact of digenic inheritance in patients management.	COL4A4 COL4A5	5.09e-05	3	144	2	27859054
Pubmed	Novel human and mouse genes encoding a shank-interacting protein and its upregulation in gastric fundus of W/WV mouse.	SHANK1 SHARPIN	5.09e-05	3	144	2	12753155
Pubmed	Sixteen novel mutations identified in COL4A3, COL4A4, and COL4A5 genes in Slovenian families with Alport syndrome and benign familial hematuria.	COL4A4 COL4A5	5.09e-05	3	144	2	17396119
Pubmed	Collagen types in various layers of the human aorta and their changes with the atherosclerotic process.	COL4A2 COL4A4	5.09e-05	3	144	2	3089234
Pubmed	Novel mutations in COL4A3, COL4A4, and COL4A5 in Chinese patients with Alport Syndrome.	COL4A4 COL4A5	5.09e-05	3	144	2	28542346
Pubmed	Dysregulation of the Pdx1/Ovol2/Zeb2 axis in dedifferentiated β-cells triggers the induction of genes associated with epithelial-mesenchymal transition in diabetes.	PDX1 ZEB2	5.09e-05	3	144	2	33989778
Pubmed	Identification of noncollagenous sites encoding specific interactions and quaternary assembly of alpha 3 alpha 4 alpha 5(IV) collagen: implications for Alport gene therapy.	COL4A4 COL4A5	5.09e-05	3	144	2	18930919
Pubmed	Four novel mutations identified in the COL4A3, COL4A4 and COL4A5 genes in 10 families with Alport syndrome.	COL4A4 COL4A5	5.09e-05	3	144	2	38978054
Pubmed	Alport Syndrome	COL4A4 COL4A5	5.09e-05	3	144	2	20301386
Pubmed	PAK4 suppresses RELB to prevent senescence-like growth arrest in breast cancer.	FOXN1 PAK4	5.09e-05	3	144	2	31399573
Pubmed	A human-mouse chimera of the alpha3alpha4alpha5(IV) collagen protomer rescues the renal phenotype in Col4a3-/- Alport mice.	COL4A4 COL4A5	5.09e-05	3	144	2	14507670
Pubmed	Evidence of digenic inheritance in Alport syndrome.	COL4A4 COL4A5	5.09e-05	3	144	2	25575550
Pubmed	Redefining thymus medulla specialization for central tolerance.	FOXN1 LTBR	5.09e-05	3	144	2	28830910
Pubmed	TAB2 deficiency induces dilated cardiomyopathy by promoting RIPK1-dependent apoptosis and necroptosis.	RIPK3 TAB2	5.09e-05	3	144	2	34990405
Pubmed	Unbiased next generation sequencing analysis confirms the existence of autosomal dominant Alport syndrome in a relevant fraction of cases.	COL4A4 COL4A5	5.09e-05	3	144	2	24033287
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	EP400 PPRC1 PPP6R1 ZEB2 USP19 GSE1 MCM3AP PACS2 SEZ6L	5.34e-05	407	144	9	12693553
Pubmed	Modulating TRADD to restore cellular homeostasis and inhibit apoptosis.	RIPK3 TAB2 SHARPIN	5.42e-05	18	144	3	32968279
Pubmed	Transcription factor Sp1 is essential for early embryonic development but dispensable for cell growth and differentiation.	COL4A2 COL4A4 COL4A5	5.42e-05	18	144	3	9160753
Pubmed	Identification of motif-based interactions between SARS-CoV-2 protein domains and human peptide ligands pinpoint antiviral targets.	ETV5 KMT2E ATXN7 GLI3 BSN TEX28 TNS3	5.59e-05	233	144	7	37704626
Interaction	TOP3B interactions	COL4A5 SPIRE2 ARID3A EP400 PPRC1 ESYT1 SAMD4B ZBTB4 OBSCN ADGRB2 FBRSL1 LMTK2 RAPGEF1 FGFRL1 PPP6R1 ATG2A IFNLR1 PHC2 MDN1 CELSR3 G3BP1 TMEM259 MCM3AP PLA2G6 LTBP3 DTX2 CABIN1 AHNAK2	8.58e-07	1470	140	28	int:TOP3B
Interaction	CRX interactions	BCL9L ARID3A EP400 FBRSL1 MIDEAS ZEB2 M1AP PRR35 ATXN7 HGS	1.16e-05	254	140	10	int:CRX
Interaction	USP54 interactions	CHERP TNIP2 NUDT22 BCAR1 PRR35 HGS SHARPIN PLA2G6 DTX2	1.77e-05	212	140	9	int:USP54
Cytoband	11q13.1	EFEMP2 NUDT22 ATG2A LTBP3	4.79e-05	63	144	4	11q13.1
Cytoband	3p21.31	USP19 P4HTM CELSR3 BSN	2.88e-04	100	144	4	3p21.31
GeneFamily	Zinc fingers CCCH-type	ZC3H6 MBNL2 RBM27	8.14e-04	35	95	3	73
GeneFamily	Zinc fingers SWIM-type\|Mitogen-activated protein kinase kinase kinases	ZSWIM8 MAP3K1	9.60e-04	9	95	2	90
Coexpression	NABA_BASEMENT_MEMBRANES	COL4A2 COL4A4 COL4A5 NID2 LAMB4 NPNT	8.15e-08	40	144	6	M5887
Coexpression	NABA_CORE_MATRISOME	INTS6L COL4A2 COL4A4 COL4A5 NID2 LAMB4 EFEMP2 ACAN LTBP3 NPNT	3.07e-06	275	144	10	M5884
Coexpression	NABA_CORE_MATRISOME	INTS6L COL4A2 COL4A4 COL4A5 NID2 EFEMP2 ACAN LTBP3 NPNT	1.94e-05	270	144	9	MM17057
Coexpression	MILI_PSEUDOPODIA_HAPTOTAXIS_DN	COL4A2 COL4A5 ZNF142 PCDHGB1 ESYT1 SLC22A23 PHRF1 LMTK2 FGFRL1 USP19 PPP1R10 TMEM259 LTBP3 HYAL2	3.48e-05	703	144	14	MM1055
Coexpression	YAMAZAKI_TCEB3_TARGETS_UP	INTS6L COL4A2 COL4A5 NID2 EFEMP2 MBNL2 B4GALNT2	3.82e-05	166	144	7	M1542
Coexpression	CHARAFE_BREAST_CANCER_LUMINAL_VS_BASAL_UP	ZSWIM8 ERBB3 ARID3A NACA ADGRB2 FBRSL1 PGR P4HTM GSE1 EIF3B	5.58e-05	385	144	10	M2840
Coexpression	YAMAZAKI_TCEB3_TARGETS_UP	INTS6L COL4A2 COL4A5 NID2 EFEMP2 MBNL2 B4GALNT2	6.16e-05	179	144	7	MM660
Coexpression	MONNIER_POSTRADIATION_TUMOR_ESCAPE_UP	SPIRE2 NOA1 SLC22A23 RAPGEF1 USP19 PPP1R10 INTS6 RBM27 EIF3B TNS3	9.02e-05	408	144	10	M11891
Coexpression	MILI_PSEUDOPODIA_HAPTOTAXIS_DN	COL4A2 COL4A5 ZNF142 ESYT1 SLC22A23 PHRF1 LMTK2 FGFRL1 USP19 PPP1R10 TMEM259 LTBP3 HYAL2	1.02e-04	681	144	13	M5314
Coexpression	MONNIER_POSTRADIATION_TUMOR_ESCAPE_UP	SPIRE2 NOA1 SLC22A23 RAPGEF1 USP19 PPP1R10 INTS6 RBM27 EIF3B TNS3	1.04e-04	415	144	10	MM1028
Coexpression	GINESTIER_BREAST_CANCER_ZNF217_AMPLIFIED_DN	NEU4 PPRC1 FBRSL1 APBA3 NCKAP5L MDN1 TMEM259 EIF3B BRD1	1.10e-04	338	144	9	M17094
Coexpression	GSE12845_NAIVE_VS_DARKZONE_GC_TONSIL_BCELL_UP	ARID3A ESYT1 APBA3 ZEB2 GSE1 ACAN LTBP3	1.16e-04	198	144	7	M3200
Coexpression	GSE17721_POLYIC_VS_GARDIQUIMOD_1H_BMDC_UP	COL4A4 BCL9L RAPGEF1 ATXN7 FUBP1 ADAM33 DTX2	1.23e-04	200	144	7	M4016
Coexpression	GSE43863_TH1_VS_TFH_MEMORY_CD4_TCELL_DN	INTS6L ARID3A POU2AF1 MIDEAS PHC2 GLI3 HGS	1.23e-04	200	144	7	M9735
Coexpression	ZENG_GU_ICB_CONTROL_METAGENE_31_PRECICTIVE_ICB_RESISTANCE	ADGRB2 FAM131C ETV5 POU2AF1 HUNK SIX2 SEZ6L	1.27e-04	201	144	7	MM17086
ToppCell	LPS_IL1RA-Epithelial_alveolar-AT_1-Differentiating_AT1\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	COL4A4 NID2 SLC22A23 MISP PLA2G6 LTBP3 TNS3 NPNT	2.75e-07	198	144	8	b598ab958e31f1e98bd06dc0097b58ac3a3f90a3
ToppCell	LPS_IL1RA_TNF-Epithelial_alveolar-AT_1-Differentiating_AT1\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	COL4A4 NID2 SLC22A23 MISP PLA2G6 LTBP3 TNS3 NPNT	2.97e-07	200	144	8	ddfb1f006365bf16203ee49f20200f68220cc288
ToppCell	Frontal_cortex-Macroglia-POLYDENDROCYTE\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	NEU4 ERBB3 PAK4 METRN GUCY2F ACAN TNS3	1.33e-06	169	144	7	50cc0f5a022b95986949db63208a627cef9f4a69
ToppCell	PND28-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1-AT1_mature\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	COL4A4 COL4A5 ERBB3 MFSD2B IFNLR1 AHNAK2 NPNT	1.88e-06	178	144	7	a3af5d9c55858e36be0498081029ecb0acaeb3d3
ToppCell	PND28-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	COL4A4 COL4A5 ERBB3 MFSD2B IFNLR1 AHNAK2 NPNT	1.88e-06	178	144	7	b3b88989bd602cfb55bb5c47731deb99288a8952
ToppCell	mild-B_cell\|mild / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	COL4A4 PGBD1 RAPGEF1 POU2AF1 APBA3 ENAM PLA2G6	2.26e-06	183	144	7	175aaf8fbbff52eab87d78a49d5ab02cd489c438
ToppCell	LPS_anti-TNF-Epithelial_alveolar-AT_1-Differentiating_AT1\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	COL4A4 NID2 SLC22A23 MISP PLA2G6 LTBP3 NPNT	3.92e-06	199	144	7	d43c605a4ff221cf78d91678c15d2ad20f831c7f
ToppCell	LPS_anti-TNF-Epithelial_alveolar-AT_1\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	COL4A4 NID2 SLC22A23 MISP PLA2G6 LTBP3 NPNT	4.06e-06	200	144	7	8683445ad5b70748c4a1f12eb77d47623085147e
ToppCell	5'-Airway_Nasal-Epithelial-Airway_epithelium-respiratory_basal_cell-Basal_resting-Basal_resting_L.0.0.0.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	COL4A5 FOXN1 LAMB4 GLI3 SIX2 AHNAK2	1.93e-05	170	144	6	0cc20322cb3e3e7bbd4daad8785c99f80e355c16
ToppCell	5'-Airway_Nasal-Epithelial-Airway_epithelium-respiratory_basal_cell-Basal_resting\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	COL4A5 FOXN1 LAMB4 GLI3 SIX2 AHNAK2	1.93e-05	170	144	6	2d880223d01bde4bf777bd6f50b7d2768489075f
ToppCell	356C-Fibroblasts-Fibroblast-C_(Myofibroblast)-\|356C / Donor, Lineage, Cell class and subclass (all cells)	COL4A2 NID2 IL17B EFEMP2 PGR LOXL1	2.42e-05	177	144	6	cdfd2f0ee2f692271b1525e414b0f645cdadb1f6
ToppCell	356C-Fibroblasts-Fibroblast-C_(Myofibroblast)\|356C / Donor, Lineage, Cell class and subclass (all cells)	COL4A2 NID2 IL17B EFEMP2 PGR LOXL1	2.42e-05	177	144	6	db222faaecbe5600da39277243c4e7e764eb63c9
ToppCell	LPS-antiTNF-Epithelial_alveolar-AT_1-Differentiating_AT1\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	COL4A4 COL4A5 SLC22A23 MISP TNS3 NPNT	2.75e-05	181	144	6	b45b11428d13950369347e051d4d517efb2bd4fd
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	NID2 CTTNBP2 HUNK MAP3K1 TNS3 NPNT	2.75e-05	181	144	6	6956ecd6264f7469a25e555673bce4eb97d28f7a
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Macula_Densa_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	COL4A4 LAMB4 ARID3A ETV5 TSC22D2 NPNT	2.75e-05	181	144	6	22363c5835dd6cef8f895ab9362e0837d92b15b1
ToppCell	5'-Adult-LymphNode-Mesenchymal-myocytic\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	NID2 EFEMP2 ZBTB4 PGBD1 ADAM33 DMPK	2.92e-05	183	144	6	d67454baf0cf791a743b51afd1cb25bfb5765385
ToppCell	3'-Child09-12-SmallIntestine-Mesenchymal-myocytic-myofibroblast\|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	COL4A2 LAMB4 ADAM33 SEZ6L AHNAK2 NPNT	2.92e-05	183	144	6	6b5eef96b28911c752a8b6c0975918c4572cec38
ToppCell	5'-Adult-LymphNode-Mesenchymal-myocytic-myofibroblast_(RSPO2+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	NID2 EFEMP2 ZBTB4 PGBD1 ADAM33 DMPK	2.92e-05	183	144	6	e49ac8314b6fe98426b1514ea68d646297b8bc0f
ToppCell	AT1-AT2_cells-Donor_02\|World / lung cells shred on cell class, cell subclass, sample id	COL4A2 COL4A4 COL4A5 ERBB3 LMTK2 NPNT	2.92e-05	183	144	6	6821dca076318115d360ff426eb1218cfe104063
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_1\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	COL4A4 CTTNBP2 SLC22A23 HUNK MAP3K1 TNS3	3.01e-05	184	144	6	da06ff24ee2b2cf4715fdfce43030b2da9e0aaf8
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	COL4A2 COL4A5 NID2 CTTNBP2 ADGRB2 LOXL1	3.40e-05	188	144	6	b21e93a70583c30d05c0833cd3d4d4bca44a039e
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	COL4A2 COL4A5 NID2 CTTNBP2 ADGRB2 LOXL1	3.40e-05	188	144	6	874404a4fd9aa42873f6c53dc42da22d3b0fdb9e
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	COL4A2 COL4A4 CTTNBP2 HUNK MAP3K1 TNS3	3.71e-05	191	144	6	d0e9afe7b6334dd515d3e68892efdc76347a55e5
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Mesenchymal-Pericytes-Contractile_pericyte_(PLN+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	COL4A2 IL17B ESAM ZSCAN5B ACAN DMPK	3.82e-05	192	144	6	dee97f650ae6f4d07a142ade402aae1905791a22
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_COL13A1^pos_fibro1_(4)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	CTTNBP2 SLC22A23 ZEB2 PGR MAST4 NPNT	3.93e-05	193	144	6	9f69edc97b868d23998abc98928a2e89a885ef8a
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Mesenchymal-myocytic\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	COL4A2 PSD IL17B DMPK AHNAK2 NPNT	3.93e-05	193	144	6	b1893193766ae41bf2ab6ed4083285c9c814e608
ToppCell	10x_5'_v1-Non-neoplastic-Lymphoid-NK-NK-Z\|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	RIPK3 EP400 FGFRL1 TUBGCP6 INTS6 LRRC37A	4.05e-05	194	144	6	3211d89440a6f4a9b3d4cfb755890816944242ec
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Mesenchymal-myocytic-SMC_(PLPP2+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	COL4A2 PSD IL17B DMPK AHNAK2 NPNT	4.05e-05	194	144	6	bea369e9a7018d862e4d7f1c9ec2de50f3fd38ec
ToppCell	mild-B_cell\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	COL4A4 PGBD1 RAPGEF1 POU2AF1 APBA3 ENAM	4.16e-05	195	144	6	1e5f1967bcc898318f4e970b844b4a944eb168e5
ToppCell	3'-Pediatric_IBD-SmallIntestine-Mesenchymal-myocytic-myofibroblast\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	COL4A2 LAMB4 EFEMP2 SEZ6L AHNAK2 NPNT	4.16e-05	195	144	6	eb2003d4f15cad213d17eda8ab7479f5a0c62164
ToppCell	3'-Pediatric_IBD-SmallIntestine-Mesenchymal-myocytic\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	COL4A2 LAMB4 EFEMP2 SEZ6L AHNAK2 NPNT	4.16e-05	195	144	6	44f67437ea65d530133a0240b17f9860d9cc0e99
ToppCell	kidney_cells-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	COL4A2 COL4A5 NID2 CTTNBP2 ADGRB2 LOXL1	4.28e-05	196	144	6	34e79918a448f6c19b87e1b1ce13c012b24be1f8
ToppCell	kidney_cells-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	COL4A2 COL4A5 NID2 CTTNBP2 ADGRB2 LOXL1	4.28e-05	196	144	6	8f82e01ca50aa4cd6149547505b4474a02fad618
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	COL4A2 COL4A4 NID2 MBNL2 LOXL1 TNS3	4.41e-05	197	144	6	85a8f1d18e0dd1d31341f5131eecd217553bf042
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	COL4A2 COL4A4 NID2 MBNL2 LOXL1 TNS3	4.41e-05	197	144	6	e8e3ba791dfaa0fab35e0329a5e34376f9ee6143
ToppCell	10x3'2.3-week_17-19-Endothelial-stroma-tip_EC\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	COL4A2 NID2 ESAM BCAR1 MAST4 HYAL2	4.41e-05	197	144	6	b212ff28ca2d1fea4140f186ab90941bdca21249
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Vascular-Mural_cell-Pericyte-F\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	COL4A2 PGR MAST4 LTBR SLC23A1 TNS3	4.41e-05	197	144	6	2872a78b1be61aa1d50bc9a49294a21e922dc033
ToppCell	Control_saline-Epithelial_alveolar-AT_1-Differentiating_AT1\|Control_saline / Treatment groups by lineage, cell group, cell type	COL4A4 NID2 MISP LTBP3 TNS3 NPNT	4.53e-05	198	144	6	85f424cd9bb3117c9e322031024aabb87696ce47
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Pvalb-Pvalb_Reln_Itm2a\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	PCDHGB1 IFNLR1 NKX6-3 ACAN	4.56e-05	61	144	4	59471f0b5235dcf9420d14221a9b4d75a8ddf78e
ToppCell	LPS_IL1RA_TNF-Epithelial_alveolar-AT_1\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	COL4A4 NID2 MISP LTBP3 TNS3 NPNT	4.66e-05	199	144	6	1c70e7d6bd25980e1b92aa1cac3f3c95d9651b4b
ToppCell	LPS_IL1RA-Epithelial_alveolar-AT_1\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	COL4A4 COL4A5 SLC22A23 MISP LTBP3 NPNT	4.66e-05	199	144	6	a270630626df614f8605abddb7dee7c4d74f6149
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW26\|fetalBrain_Zhong_nature / Sample Type, Dataset, Time_group, and Cell type.	PSD OBSCN MAST4 ANKRD24 SEZ6L NPNT	4.79e-05	200	144	6	61d7dd0a78942b069c3f5e75044368dc00e6e8e6
ToppCell	droplet-Trachea-3m-Mesenchymal-fibroblast\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	EFEMP2 ETV5 FGFRL1 ACAN LTBP3 NPNT	4.79e-05	200	144	6	be527df943a8cedc6452ecef3cafc282db34ceb8
ToppCell	LPS_only-Epithelial_alveolar-AT_1-Differentiating_AT1\|LPS_only / Treatment groups by lineage, cell group, cell type	COL4A4 COL4A5 SLC22A23 MISP LTBP3 NPNT	4.79e-05	200	144	6	2dadf317a42a7e27cc1fac74f91b806c93a57108
ToppCell	droplet-Trachea-3m-Mesenchymal-fibroblast-fibroblast_of_trachea-tracheal_fibroblast_l28\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	EFEMP2 ETV5 FGFRL1 ACAN LTBP3 NPNT	4.79e-05	200	144	6	d254f6634895486f81d7a8b6f006fbc2679eaa5b
ToppCell	droplet-Trachea-3m-Mesenchymal-fibroblast-fibroblast_of_trachea\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	EFEMP2 ETV5 FGFRL1 ACAN LTBP3 NPNT	4.79e-05	200	144	6	8e41a484038216f0c2ad258fd46c0e702a4bb8bf
ToppCell	droplet-Trachea-nan-3m-Mesenchymal-fibroblast\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EFEMP2 ETV5 FGFRL1 ACAN LTBP3 NPNT	4.79e-05	200	144	6	c935caef2988f165e96d8f1ef99ae8963ab9377f
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW26\|organoid_Tanaka_cellReport / Sample Type, Dataset, Time_group, and Cell type.	PSD OBSCN MAST4 ANKRD24 SEZ6L NPNT	4.79e-05	200	144	6	5c7263c862093ad9dbc81d06b16b6f74e8a6b634
ToppCell	frontal_cortex-Non-neuronal-oligodendrocyte-Oligo-OPC_Pdgfra_Grm5\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	NEU4 FGFRL1 GUCY2F ACAN TNS3	7.25e-05	133	144	5	63d2f096ae47d9b587acc6c5fbd346e5e58842b8
ToppCell	3'-GW_trimst-2-SmallIntestine-Mesenchymal-immature_mesenchymal_cell-Mesoderm_1_(HAND1+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	COL4A4 ADGRB2 ANKRD24 DTX2 BSN	7.78e-05	135	144	5	5113bb1713f99d01103b9a99de5d80393081cf87
ToppCell	Posterior_cortex-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Pvalb\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	TMC2 TOGARAM2 NKX6-3 ACAN	9.73e-05	74	144	4	06760e7179980685beddaaf7b14f4f9f932fe79c
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Outer_Medullary_Collecting_Duct_Intercalated_Cell_Type_A\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PNMT SLC22A23 ENAM M1AP CELSR3	1.05e-04	144	144	5	cc11cce43d1af8ac63140d05faf215ae9a10cde1
ToppCell	TCGA-Breast-Primary_Tumor-Breast_Carcinoma-Ductal_and_Mucinous_Carcinoma-1\|TCGA-Breast / Sample_Type by Project: Shred V9	PSD SYN1 BSN SIX2 SEZ6L	1.09e-04	145	144	5	1e52e3c615b49e7388cd58a04e74cafac9552447
ToppCell	TCGA-Breast-Primary_Tumor-Breast_Carcinoma-Mucinous_Carcinoma-1\|TCGA-Breast / Sample_Type by Project: Shred V9	PSD P4HTM SYN1 BSN SEZ6L	1.24e-04	149	144	5	649eb3441fa859591ea85f1ed5fcf08af272a32b
ToppCell	Substantia_nigra-Macroglia-POLYDENDROCYTE\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	NEU4 ERBB3 PAK4 BCAR1 TNS3	1.28e-04	150	144	5	70ac8ae4b1683fb17278a8e4606f2fa0b94988c0
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_3\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	COL4A4 COL4A5 HUNK MAP3K1 TNS3	1.32e-04	151	144	5	16fc903fc71e25717b9908416f0bcd29c0a65a61
ToppCell	lymphoid-T_cell-pro-T_cell\|World / Lineage, cell class and subclass	ZSWIM8 OBSCN ANKRD63 MIDEAS	1.32e-04	80	144	4	9bd3ad5029eb84efcdbf08fe268c29fa9b0b302b
ToppCell	Adult-Immune-mast_cell-D122\|Adult / Lineage, Cell type, age group and donor	INTS6L TMC2 PNMT MFSD2B BSN	1.49e-04	155	144	5	7c9de0591d1bf756b8e268b278bbe10bd5415dcd
ToppCell	3'_v3-blood-Lymphocytic_Invariant-Inducer-like-ILC3\|blood / Manually curated celltypes from each tissue	SHANK1 COL4A4 PNMT MFSD2B SIX2	1.58e-04	157	144	5	eb2520c237543ea4869d4386afc0457b111f6193
ToppCell	BL-critical-LOC-Myeloid-Basophil\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	INTS6L CTTNBP2 PNMT ADGRB2 GSE1	1.83e-04	162	144	5	25ec9df914445b4daae4fd28fd0e60b64797c46d
ToppCell	droplet-Liver-Hepatocytes-24m-Myeloid-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SHANK1 ETV5 WDFY4 METRN SYN1	1.88e-04	163	144	5	8dc0128eeede933537e3bcc5d6ec0322711552f3
ToppCell	droplet-Liver-Hepatocytes-24m-Myeloid-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SHANK1 ETV5 WDFY4 METRN SYN1	1.88e-04	163	144	5	fd243ca223079033be480a24817a399f281fa4d4
ToppCell	TCGA-Colorectal-Primary_Tumor-Colorectal_Adenocarcinoma-Colon_Adenocarcinoma-3\|TCGA-Colorectal / Sample_Type by Project: Shred V9	POLD1 FGFRL1 APBA3 P4HTM HYAL2	1.94e-04	164	144	5	201aee6387e69f918d87fa87d9b5b2ab3b305f61
ToppCell	Thalamus-Macroglia-POLYDENDROCYTE\|Thalamus / BrainAtlas - Mouse McCarroll V32	NEU4 ERBB3 IL17B PAK4 BCAR1	2.11e-04	167	144	5	1e144c03409df94ccd39760842590e8ea7487e29
ToppCell	facs-Liver-Hepatocytes-24m-Myeloid-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NID2 ETV5 WDFY4 SYN1 DMPK	2.16e-04	168	144	5	04e168fe1d6f5f9e3d3bf9d7c13e800e3594868a
ToppCell	Control-Mast_cells\|Control / group, cell type (main and fine annotations)	INTS6L CTTNBP2 MFSD2B ZEB2 GSE1	2.23e-04	169	144	5	fdb9abca1d0f4fdc32dd8ac6231651ef34aa5afb
ToppCell	droplet-Marrow-nan-3m-Myeloid-basophil\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PAK4 RAPGEF1 ZEB2 CELSR3 ADAM33	2.23e-04	169	144	5	5f5bec13208f4c3b6eacbba180c8a6402743b76e
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_3\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	COL4A4 CTTNBP2 HUNK MAP3K1 TNS3	2.29e-04	170	144	5	5d5f208682be21ed58320f5fc083a7898f8712da
ToppCell	Control-Mast_cells-Mast_cells\|Control / group, cell type (main and fine annotations)	INTS6L CTTNBP2 MFSD2B ZEB2 GSE1	2.29e-04	170	144	5	c80f6d29096c372da95a8407f402349ff1bb7018
ToppCell	5'-Adult-Appendix-Mesenchymal-myocytic\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	COL4A2 COL4A5 FAM131C ADAM33 NPNT	2.48e-04	173	144	5	f8e3dded726bb3a6c24bfedf8c6732bb46262308
ToppCell	Mesenchymal_cells-Osteo-CAR\|Mesenchymal_cells / Lineage and Cell class	HUNK WDFY4 ZEB2 TNS3 NPNT	2.55e-04	174	144	5	430e3cd61bc2a471959faa40e817aa4dd7d82d28
ToppCell	PND14-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1/AT2\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	COL4A4 COL4A5 ALDH1L1 MISP LTBP3	2.61e-04	175	144	5	96219e58dcb327fd27190be78193e7a0d611e62b
ToppCell	facs-Trachea-24m-Mesenchymal-fibroblast-fibroblast_of_trachea-tracheal_fibroblast_l28\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	FBRSL1 FGFRL1 NCKAP5L TUBGCP6 NPNT	2.61e-04	175	144	5	aa168aeb9ad71aa6c0c28a0657c9eb92a0b28183
ToppCell	PND14-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1/AT2-AT1/AT2_mature\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	COL4A4 COL4A5 ALDH1L1 MISP LTBP3	2.61e-04	175	144	5	cb974fbebe8cb58c7d3f7defabb4e056f2fee5fa
ToppCell	droplet-Kidney-nan-18m-Epithelial-collecting_duct_principal_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FAM131C FGFRL1 MIDEAS IFNLR1 PGR	2.68e-04	176	144	5	533d544852038c0612aacf87f4b1c88ff7aace82
ToppCell	TCGA-Endometrium-Primary_Tumor-Endometrial_Adenocarcinoma-Endometrioid-2\|TCGA-Endometrium / Sample_Type by Project: Shred V9	APBA3 TUBGCP6 P4HTM TMEM259 DTX2	2.68e-04	176	144	5	179b1778e8f6c4cd777cec971960211e7ba5d84a
ToppCell	facs-Heart-LV-18m-Mesenchymal-fibroblast_of_cardiac_tissue\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL4A4 IL17B LOXL1 GLI3 LTBP3	2.68e-04	176	144	5	fee4e0f32aaf77294040c7af6c1f503571750d43
ToppCell	facs-Heart-LV-18m-Mesenchymal-fibroblast_of_cardiac_tissue\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL4A4 IL17B LOXL1 GLI3 LTBP3	2.68e-04	176	144	5	f25251abd4ef9fb077a978f9f9f658af58e4e0d2
ToppCell	facs-Trachea-24m-Hematologic-lymphocytic-B_cell\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ARID3A POLD1 POU2AF1 WDFY4 MAP3K1	2.68e-04	176	144	5	318dc722b95e269002fb01a0feb91c0c8539e150
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CTTNBP2 SLC22A23 HUNK MAP3K1 TNS3	2.68e-04	176	144	5	327a3e81b724252e36d786de92a3ffd721ea6d7b
ToppCell	facs-Trachea-24m-Hematologic-lymphocytic-B_cell-B_cell_of_the_trachea\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ARID3A POLD1 POU2AF1 WDFY4 MAP3K1	2.68e-04	176	144	5	f6891006d816309edabe75b2abf60675f2958e55
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_1\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	COL4A2 CTTNBP2 SLC22A23 HUNK TNS3	2.75e-04	177	144	5	da8802a6351d3e510822f82e2fde8a4314a2216e
ToppCell	droplet-Lung-1m-Hematologic-lymphocytic-Zbtb32+_B_cell\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	POLD1 POU2AF1 ENAM MISP B4GALNT2	2.75e-04	177	144	5	a58c93be9767e3fe8fbb6b0db1210d3a33aac662
ToppCell	tumor_Lung-Endothelial_cells-EPCs\|tumor_Lung / Location, Cell class and cell subclass	COL4A2 LAMB4 LRRC37A3 ESAM HYAL2	2.75e-04	177	144	5	f8b152c09d56a97e8c0482fb1a3964c05f9dc8c5
ToppCell	droplet-Lung-1m-Hematologic-lymphocytic-Zbtb32+_B_cell-Zbtb32+_B_cell\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	POLD1 POU2AF1 ENAM MISP B4GALNT2	2.75e-04	177	144	5	3ed383e5c0b15d9d5e75b98cf6d10609f48fc422
ToppCell	Control-Epithelial_alveolar-AT_1-Differentiating_AT1\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	COL4A4 COL4A5 SLC22A23 TNS3 NPNT	2.75e-04	177	144	5	9af14a056eb6d88c6f11b09f6d4c0d3448d647d5
ToppCell	Posterior_cortex-Macroglia-POLYDENDROCYTE-P2-Tnr-Polydendrocyte.Tnr.Lims2-Tmsb4x_(Lims2)\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	NEU4 PRR35 GUCY2F ACAN	2.77e-04	97	144	4	2b69f41f0aca06da6705376bb6f530ee0e9ac737
ToppCell	Posterior_cortex-Macroglia-POLYDENDROCYTE-P2-Tnr-Polydendrocyte.Tnr.Lims2-Tmsb4x_(Lims2)-\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	NEU4 PRR35 GUCY2F ACAN	2.77e-04	97	144	4	75485ac0dca0dd6a01fe0abf679b984529d46c79
ToppCell	LPS-IL1RA-Epithelial_alveolar-AT_1-Differentiating_AT1\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	COL4A4 COL4A5 SLC22A23 TNS3 NPNT	2.90e-04	179	144	5	04ce3673e46606f63d9c87bcba3a64c96817d812
ToppCell	IIH-CD8-CD4_Treg\|IIH / Condition, Cell_class and T cell subcluster	PPRC1 LMTK2 METRN LOXL1 PLA2G6	2.98e-04	180	144	5	d1a8b25115c80e5a5bd0b8244167a98250ab9778
ToppCell	facs-Lung-3m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l17\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	COL4A4 COL4A5 NID2 LOXL1 LTBP3	2.98e-04	180	144	5	39ae8586efd91536e9ac6408d26de7e6d6237c41
ToppCell	3'-Pediatric_IBD-SmallIntestine-Mesenchymal-fibroblastic-mLTo\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	COL4A4 EFEMP2 LOXL1 GLI3 TNS3	2.98e-04	180	144	5	d1c52aeceb3627e3c5fb6cc3af77e0400f9380ab
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	COL4A5 CTTNBP2 HUNK MAP3K1 TNS3	3.05e-04	181	144	5	9d782ba5cf5a172cb4f447763fc50e5b13ef7dd9
ToppCell	Pericytes-Donor_01\|World / lung cells shred on cell class, cell subclass, sample id	NID2 CTTNBP2 IL17B ADAM33 DMPK	3.05e-04	181	144	5	ff445a8e56522e57e27405184d123cf905caf8cc
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_3\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	COL4A5 CTTNBP2 HUNK MAP3K1 TNS3	3.13e-04	182	144	5	eb138aa1dca9373f1586600f258df06dcf56d81f
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Non-neuronal-Macroglial-Oligo-OPC\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	NEU4 ERBB3 MAP3K1 TNS3 SEZ6L	3.13e-04	182	144	5	3cc61f5f7ad4a81eba3daf65e122880b5af3adc0
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Non-neuronal-Macroglial-Oligo-OPC-OPC_L1-6_MYT1\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	NEU4 ERBB3 MAP3K1 TNS3 SEZ6L	3.13e-04	182	144	5	5d909e4b5f662905bf1be9c686bbddc3e87d2be9
ToppCell	tumor_Lung-Fibroblasts-Pericytes\|tumor_Lung / Location, Cell class and cell subclass	COL4A2 NID2 IL17B EFEMP2 ACAN	3.21e-04	183	144	5	a03dd563af9b15cb1f5de5732a229405a9f82d84
ToppCell	LPS_only-Epithelial_alveolar-AT_1-Differentiating_AT1\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	COL4A4 COL4A5 SLC22A23 TNS3 NPNT	3.29e-04	184	144	5	42ce855b4f8475a8298192feec785bdc69bc5bb0
ToppCell	Mild/Remission-B_intermediate-6\|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)	BCL9L ARID3A TNIP2 WDFY4 ZEB2	3.29e-04	184	144	5	3d4864605c812862cf8926e02370eea3b8ccf32f
Disease	Alport syndrome	COL4A4 COL4A5	6.31e-05	3	136	2	cv:C1567741
Disease	Collagen IV-related nephropathies	COL4A4 COL4A5	6.31e-05	3	136	2	cv:CN076135
Disease	Hematuria, Benign Familial	COL4A4 COL4A5	1.26e-04	4	136	2	C0241908
Disease	Alport Syndrome	COL4A4 COL4A5	1.26e-04	4	136	2	C1567741
Disease	age-related hearing impairment	FOXN1 NID2 SPIRE2 ADGRB2 VTA1 M1AP ACAN GLI3	1.35e-04	324	136	8	EFO_0005782
Disease	Alport Syndrome, X-Linked	COL4A4 COL4A5	2.09e-04	5	136	2	C1567742
Disease	Alport Syndrome, Autosomal Dominant	COL4A4 COL4A5	2.09e-04	5	136	2	C1567743
Disease	Alport Syndrome, Autosomal Recessive	COL4A4 COL4A5	2.09e-04	5	136	2	C1567744
Disease	myotonic dystrophy type 1 (implicated_via_orthology)	MBNL2 DMPK	3.13e-04	6	136	2	DOID:11722 (implicated_via_orthology)
Disease	primary biliary cirrhosis	ARID3A SLC22A23 POU2AF1 WDFY4 LTBR	3.87e-04	133	136	5	EFO_1001486
Disease	glucose measurement	LRRC37A3 FBRSL1 PDX1 ARMC2 IFNLR1 LRRC37A GLI3 BSN	3.95e-04	380	136	8	EFO_0004468
Disease	coronary artery disease	COL4A2 COL4A4 NOA1 TAB2 BCAR1 ZEB2 MAP3K1 ENAM MAST4 LOXL1 B4GALNT2 BSN CABIN1 TNS3 SEZ6L	4.16e-04	1194	136	15	EFO_0001645
Disease	tumor necrosis factor ligand superfamily member 6, soluble form measurement	CELSR3 BSN	4.36e-04	7	136	2	EFO_0020797
Disease	household income	ERBB3 CTTNBP2 SLC22A23 ADGRB2 KMT2E MAST4 BSN	5.41e-04	304	136	7	EFO_0009695
Disease	hippocampal CA3 volume	SLC22A23 MAP3K1 GLI3	6.12e-04	36	136	3	EFO_0009395
Disease	creatinine measurement	COL4A2 SPIRE2 OBSCN ETV5 POU2AF1 ALDH1L1 PHC2 CELSR3 G3BP1 ATXN7 PLA2G6 BSN SLC23A1	7.14e-04	995	136	13	EFO_0004518
Disease	hepatocyte growth factor-like protein measurement	USP19 CELSR3 BSN	7.18e-04	38	136	3	EFO_0008154
Disease	cup-to-disc ratio measurement	CTTNBP2 RAPGEF1 INTS6 LOXL1 GLI3 PLA2G6 LTBP3 NPNT	8.86e-04	430	136	8	EFO_0006939
Disease	reticulocyte count	SPIRE2 ARID3A MFSD2B FGFRL1 TSC22D2 MIDEAS MAP3K1 DCAF10 ADAM33 PLA2G6 BSN SLC23A1 TNS3	1.12e-03	1045	136	13	EFO_0007986
Disease	pancreatic carcinoma	PNMT NACA PDX1 BCAR1 TNS3	1.30e-03	174	136	5	EFO_0002618
Disease	Amelogenesis Imperfecta	ENAM LTBP3	1.35e-03	12	136	2	C0002452
Disease	collagen disease (implicated_via_orthology)	COL4A4 COL4A5	1.35e-03	12	136	2	DOID:854 (implicated_via_orthology)
Disease	Malignant neoplasm of breast	NID2 ERBB3 NOA1 LRRC37A2 OBSCN BCAR1 ZEB2 MAP3K1 PGR LRRC37A GUCY2F MROH7 ADAM33	1.42e-03	1074	136	13	C0006142
Disease	urinary nitrogen measurement	POLD1 TUBGCP6	1.85e-03	14	136	2	EFO_0005190
Disease	peak expiratory flow	COL4A2 VTA1 TAB2 KMT2E ARMC2 ACAN BRD1 NPNT	2.23e-03	498	136	8	EFO_0009718
Disease	Global developmental delay	ZNF142 KMT2E P4HTM PACS2	3.40e-03	133	136	4	C0557874
Disease	obsolete_red blood cell distribution width	EP400 SLC22A23 LRRC37A2 FBRSL1 MFSD2B MIDEAS MAP3K1 MAST4 G3BP1 RBM27 TMEM259 ATXN7 PLA2G6 SLC23A1	3.79e-03	1347	136	14	EFO_0005192
Disease	osteoarthritis (biomarker_via_orthology)	EFEMP2 ACAN	4.18e-03	21	136	2	DOID:8398 (biomarker_via_orthology)
Disease	FEV/FEC ratio	COL4A2 NID2 ERBB3 CTTNBP2 TNIP2 VTA1 ARMC2 ZEB2 MAP3K1 ACAN ADAM33 LTBP3 NPNT	4.50e-03	1228	136	13	EFO_0004713

Protein segments in the cluster

Peptide	Gene	Start	Entry
LVPGGPAPPAEADLH	ADGRB2	251	O60241
ESGPGIAPGPEPHGL	ERBB3	981	P21860
QPPAAHAKPDPGSGG	ESYT1	26	Q9BSJ8
PGGSAPAQVVHTQPP	EP400	2666	Q96L91
ASEPPAGGLHPAPLQ	FBRSL1	866	Q9HCM7
PGHHNGVTIPAPPLD	BRD1	956	O95696
GDPTGQASPAVPVPH	LINC00242	46	Q5T6M2
ELPGSHAEPPVPAQG	EIF3B	91	P55884
HAEPPVPAQGEAPGE	EIF3B	96	P55884
PLHTVPIPGLQFEGP	B4GALNT2	206	Q8NHY0
TAPGPEGGGTLHPNP	BCAR1	611	P56945
IHPGVGPVLAANPGI	ARMC2	616	Q8NEN0
GPIIVPPGGHSVPST	GSE1	106	Q14687
GIDPSQVGVHPSPGA	APBA3	361	O96018
PGNRGHPGPPGVLVT	COL4A4	346	P53420
GQPGPNGIPSDTLHP	COL4A2	246	P08572
PGAGVLQGHIPGQPV	ADAM33	26	Q9BZ11
HQLQPPGAGAPQPGV	ASB16-AS1	86	Q495Z4
VPGISAGPILHPGAA	ANKRD24	701	Q8TF21
SIPPGIQGPEHPNPG	DTX4	506	Q9Y2E6
EAPGGGHSPSPPDQQ	ATG2A	1646	Q2TAZ0
GTQHPFAPETPIPGA	ADAMTS14	1161	Q8WXS8
AQAPIGLSPHPEGGP	ANKRD63	306	C9JTQ0
SDPGPQHRAQGPGPE	P4HTM	91	Q9NXG6
QHRAQGPGPEPTLGP	P4HTM	96	Q9NXG6
APGLGSGTIPQPHPD	MROH7	26	Q68CQ1
PQGHGQPPPSVVLPI	RBM27	366	Q9P2N5
TPPTVTNHVGGKGPP	INTS6L	636	Q5JSJ4
PVVNNHIGGKGPPAP	INTS6	671	Q9UL03
LQGTPDHGDPRTPGP	MISP	161	Q8IVT2
LVPGHAPGEPQLRPV	HYAL2	396	Q12891
GNDVEPPAIQHGGPP	LRRC37A3	446	O60309
PAPGHGNVQVLGQPP	MDN1	4316	Q9NU22
KVPHGPGDFDAPGLP	GLI3	1121	P10071
AKGEPPGPGHSQRIP	M1AP	366	Q8TC57
GNDVEPPAIQHGGPP	LRRC37A2	446	A6NM11
GNDVEPPAIQHGGPP	LRRC37A	446	A6NMS7
GPTDPSQGPEGLAPH	NCKAP5L	866	Q9HCH0
PGGDGHQESLPPPEF	IFNLR1	416	Q8IU57
GQGRPGPLAPGPHQV	IL17B	31	Q9UHF5
IEPSGPIHVPKGNGT	NPNT	261	Q6UXI9
APGLVDVPGGHPEPQ	NUDT22	146	Q9BRQ3
PELPPQAHGLGVDGA	METRN	156	Q9UJH8
VNPLGPPVPHGPHGV	FUBP1	451	Q96AE4
SIPHGIQGPEHPNPG	DTX2	511	Q86UW9
KSLPGPHPGGVSAPQ	FAM182A	91	Q5T1J6
VNGGPLPPVPRHTPV	MCM3AP	966	O60318
PDPGPEAAQAHGGDP	LOXL1	291	Q08397
VGPGPHEEQRPYPQG	BSN	1961	Q9UPA5
PGLLGNPTFPEGHPS	BSN	2146	Q9UPA5
PPHPFPGALGALEQG	PDX1	46	P52945
EPALHPGPGQAPVPA	PLSCR3	26	Q9NRY6
GSPAAPQHLLGPGPV	FGFRL1	451	Q8N441
SGPGVPPNHSEGTLP	PCDHGB1	731	Q9Y5G3
LGESPGPAPPGQLHT	FAM214B	171	Q7L5A3
EPTPHEGQAAATGPP	DCAF10	21	Q5QP82
ARSPGPDGHPQVGPA	PHRF1	11	Q9P1Y6
PDGHPQVGPADPAGD	PHRF1	16	Q9P1Y6
PHGVQGPQQASPVPG	KMT2E	1821	Q8IZD2
DGGHSGLPPNPVIVI	LMTK2	1061	Q8IWU2
EPHAPEPGPGSAKRG	MFSD2B	16	A6NFX1
HPQVTSPGPEHPEGG	TUBGCP6	826	Q96RT7
AGPVQGVGPAPAPHS	ETV5	166	P41161
GVPGPREHPGQPEDS	PACS2	376	Q86VP3
GSPLQPPLLGPGVHE	NEU4	301	Q8WWR8
QQGGSAPIDPPPVHE	ATXN7	461	O15265
PPSHLDGPPAVAVGQ	DMPK	546	Q09013
TAVPGQPHLPGGVVF	ACAN	466	P16112
LQPRGPVPGSPEHVG	PRR35	391	P0CG20
GGHPGTAQPERPSPD	OBSCN	7011	Q5VST9
PDGHEVPGTQTPPGS	NID2	986	Q14112
VGPPLEGPEHQAPLT	POU2AF1	161	Q16633
APHVAGGPPSPEVGS	PGR	11	P06401
PHGPPQSPGEEGVEA	CEFIP	1401	Q711Q0
SGSAQPPEGHPGKPE	CABIN1	2106	Q9Y6J0
AAAGPRGPGPHDQIP	CHERP	401	Q8IWX8
GVPPTGDVGTHPPVG	CTTNBP2	511	Q8WZ74
PSGAVPVTGIPPHVV	G3BP1	261	Q13283
PVPPPVDKDGQVGHG	GUCY2F	1071	P51841
LQGPPGPPGTSSVAH	COL4A5	1446	P29400
RLPGAQGPEGGTHPP	FAM131C	246	Q96AQ9
EPHQPGPGSTGIPHK	HUNK	536	P57058
TQSLGGPPLEHEVPG	BCL9L	476	Q86UU0
DGAHPQPISPIPGGV	ESAM	351	Q96AP7
IADPPGPGEGPPAQH	LTBP3	191	Q9NS15
HPVPTFPVGPAIGTN	MBNL2	111	Q5VZF2
GPAGGLPHAPQDSVP	TMEM259	571	Q4ZIN3
EGEPGGFSREHQPPP	MAST4	51	O15021
PPGSLGQPHPEALGF	MIDEAS	386	Q6PJG2
PAVHVVLGEPVPGNP	LAMB4	576	A4D0S4
HPVGTTVAPLGPKPG	ENAM	411	Q9NRM1
GEAGIPGHPTPPATL	C1orf127	301	Q8N9H9
HVGGLPPGSAEEAPQ	CELSR3	1896	Q9NYQ7
AVINDLHGEGPPPPV	EFEMP2	86	O95967
IDHYVGPAQPVPGGP	POLD1	101	P28340
GLPGHGAPQTEPTKV	PPRC1	1041	Q5VV67
VVGHPDPALPPSGVN	NOA1	126	Q8NC60
PAPVAGLGPRAPHVQ	FAM8A1	196	Q9UBU6
APSPGVLGPHASEPQ	PAK4	256	O96013
SGTGFQPVAVPPPHG	MAP3K1	101	Q13233
QPVAVPPPHGAASRG	MAP3K1	106	Q13233
PPQGQQHLSGLGPPA	SYN1	486	P17600
AGPRPEPHGPVAVGQ	HSF5	176	Q4G112
VAHTLPQRPEPGEPG	SEZ6L	211	Q9BYH1
VSVLNPGELPPPHHG	SMYD4	266	Q8IYR2
GPLPGPHPSLGSGNE	PSD	336	A5PKW4
HIHGVPPPVLNSPQG	TAB2	196	Q9NYJ8
PLSAVPGGPHAVVPG	TSC22D2	491	O75157
DPGGGPQGVPLHSTI	TOGARAM2	146	Q6ZUX3
PGVPGNAGPPSHIIG	LRRC41	566	Q15345
PGLGPQLAAGTPHGI	NKX6-3	41	A6NJ46
GGAEIQPLPPLHPGG	SLC22A23	46	A1A5C7
PGLPGSPAPQSKHAG	FOXN1	31	O15353
IRGPTQHELQPPPGG	SHARPIN	81	Q9H0F6
QHELQPPPGGPGTLS	SHARPIN	86	Q9H0F6
PPIHGVPAEQGSAAP	PLA2G6	416	O60733
ASGTAGHPEPPRPQG	RNF217	21	Q8TC41
PQGNPQEVSGPVPHG	PGBD1	176	Q96JS3
GVGSGPHPPDTQQPS	TNS3	646	Q68CZ2
APVFVPPHPGISGGL	SHANK1	2051	Q9Y566
AAHPPQPGPQGSTLG	SUPT20HL2	681	P0C7V6
LPEGPVPEGAGPKVH	AHNAK2	901	Q8IVF2
PEGDALPIPGAHRPG	ALDH1L1	256	O75891
VLGGQERPGPGPAHP	ARID3A	191	Q99856
PIDVHQPQPLGAGSP	PNMT	156	P11086
SQQPEPPAEGGHPGA	TNIP2	381	Q8NFZ5
HLPPSPQAGEPGIDG	ZNF503-AS2	21	A6NEH8
PTPDTGPQNGHPEGV	PHC2	426	Q8IXK0
GPQNGHPEGVPHTPQ	PHC2	431	Q8IXK0
STPPGGAPHPLTGQE	USP19	406	O94966
GHGPLPVPGLLPAVQ	ZC3H6	651	P61129
RGLQHPPPVGSQEGP	RIPK3	486	Q9Y572
QLPLGGHPQPDGPLA	RAPGEF1	431	Q13905
GHPQPDGPLAPGQQT	RAPGEF1	436	Q13905
AGAPPPPVHAINRGI	SLC23A1	346	Q9UHI7
PGAEPPLAHPGTDKG	SAMD4B	421	Q5PRF9
GIQIPPGAHAPANTP	VTA1	211	Q9NP79
GLQSATHPPGGTEPP	SPIRE2	456	Q8WWL2
QAEINPVHSPGPAGP	ZSCAN5B	326	A6NJL1
PVPLTEPAAQPGEGH	HGS	351	O14964
PDAGLHPGVTQAPQP	WDFY4	971	Q6ZS81
LPPPVGFRGGPEHVV	ZBTB4	286	Q9P1Z0
PVPVPGGGGADPLQH	SIX2	256	Q9NPC8
GEEELHTGPPAPQGP	PPP6R1	731	Q9UPN7
EGDPGPPGLSTPHQE	LTBR	391	P36941
GNPGPHPAEEPSRGV	ZACN	341	Q401N2
PSKHGGPSAPGALQP	ZSWIM8	1041	A7E2V4
PEPGGEDGPVNLPHA	TEX28	156	O15482
RPEGPGHEPGTVVDP	ZNF142	636	P52746
PPGIGPDSGHAPSQT	TMC2	876	Q8TDI7
PNIPPVGLPVVSHNG	ZEB2	506	O60315
PHGLLGPGPIANGFP	PPP1R10	616	Q96QC0
PGPAGPVSHPSGQEV	ZSCAN5C	336	A6NGD5
GEEPPAGPPVSLHGR	nan	6	Q6ZSA8
AHEPSPGAPAPQELG	GOLGA8CP	516	A6NN73
GGLATPPHKGAPNPA	NACA	1276	E9PAV3