Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	supraspliceosomal complex	RBMXL1 RBMX	5.69e-05	4	65	2	GO:0044530
GeneOntologyCellularComponent	microtubule minus-end	SVIL NUMA1	1.98e-04	7	65	2	GO:0036449
Domain	IMD	BAIAP2L2 MTSS2	1.04e-04	5	61	2	PS51338
Domain	IMD	BAIAP2L2 MTSS2	1.56e-04	6	61	2	PF08397
Domain	RBM1CTR	RBMXL1 RBMX	2.90e-04	8	61	2	PF08081
Domain	RBM1CTR	RBMXL1 RBMX	2.90e-04	8	61	2	IPR012604
Domain	I-BAR_dom	BAIAP2L2 MTSS2	8.00e-04	13	61	2	IPR013606
Domain	RRM_dom_euk	RBMXL1 RBMX	2.54e-03	23	61	2	IPR003954
Domain	RRM_1	RBMXL1 RBMX	2.54e-03	23	61	2	SM00361
Domain	HECT	UBR5 NEDD4	3.49e-03	27	61	2	PF00632
Domain	HECTc	UBR5 NEDD4	3.49e-03	27	61	2	SM00119
Domain	HECT_dom	UBR5 NEDD4	3.49e-03	27	61	2	IPR000569
Domain	HECT	UBR5 NEDD4	3.49e-03	27	61	2	PS50237
Domain	DEAD_ATP_HELICASE	DDX20 DDX3X	4.59e-03	31	61	2	PS00039
Domain	RNA-helicase_DEAD-box_CS	DDX20 DDX3X	5.19e-03	33	61	2	IPR000629
Domain	Q_MOTIF	DDX20 DDX3X	6.49e-03	37	61	2	PS51195
Domain	RNA_helicase_DEAD_Q_motif	DDX20 DDX3X	6.49e-03	37	61	2	IPR014014
Pubmed	RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy.	ALMS1 TTC28 MEIOC SVIL TMEM131 LRRC7 EMD	6.25e-07	263	65	7	34702444
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	SNPH PXDN TTC28 UBE4B UBR5 PUM2 LRRC7 NEDD4	9.26e-07	407	65	8	12693553
Pubmed	An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.	ALMS1 TTC28 L3MBTL2 AGFG1 PUM2 PEX13 TMEM131 DDX20 XRCC1 MGA	1.02e-06	733	65	10	34672954
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	ALMS1 TTC28 UBR5 PHLPP1 PUM2 DAGLA	4.12e-06	225	65	6	12168954
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	FSIP2 ALMS1 TTC28 SVIL AGFG1 PLK4 MEX3B DDX3X MTSS2 NEDD4	4.29e-06	861	65	10	36931259
Pubmed	TBK1 phosphorylation activates LIR-dependent degradation of the inflammation repressor TNIP1.	PXDN RBMXL1 CDK13 RBMX SVIL NUMA1 DDX20 EMD XRCC1 DDX3X	1.00e-05	949	65	10	36574265
Pubmed	Transcriptional control of CBX5 by the RNA binding proteins RBMX and RBMXL1 maintains chromatin state in myeloid leukemia.	RBMXL1 RBMX	1.03e-05	3	65	2	34458856
Pubmed	RBMX is a novel hepatic transcriptional regulator of SREBP-1c gene response to high-fructose diet.	RBMXL1 RBMX	1.03e-05	3	65	2	17188681
Pubmed	NANOS1 and PUMILIO2 bind microRNA biogenesis factor GEMIN3, within chromatoid body in human germ cells.	PUM2 DDX20	1.03e-05	3	65	2	21800163
Pubmed	RBMY evolved on the Y chromosome from a ubiquitously transcribed X-Y identical gene.	RBMXL1 RBMX	1.03e-05	3	65	2	10391207
Pubmed	PUM2 promoted osteoarthritis progression through PTEN-mediated chondrocyte ferroptosis by facilitating NEDD4 mRNA degradation.	PUM2 NEDD4	1.03e-05	3	65	2	38733337
Pubmed	PMEPA1/TMEPAI Is a Unique Tumorigenic Activator of AKT Promoting Proteasomal Degradation of PHLPP1 in Triple-Negative Breast Cancer Cells.	PHLPP1 NEDD4	1.03e-05	3	65	2	34638419
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	UBR5 SVIL NUMA1 LRRC7 GRM1 MGA TRIM3 DDX3X MTSS2 NEDD4	1.14e-05	963	65	10	28671696
Pubmed	Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.	SP4 NUMA1 AGFG1 GRM1 MGA MEX3B NEDD4	1.58e-05	430	65	7	35044719
Pubmed	A High-Density Human Mitochondrial Proximity Interaction Network.	ALMS1 TTC28 RBMXL1 CDK13 RBMX FGA PUM2 PEX13 TMEM131 DDX20 EMD SUCO	1.87e-05	1496	65	12	32877691
Pubmed	Transcriptional regulation of the Alström syndrome gene ALMS1 by members of the RFX family and Sp1.	ALMS1 RFX1	2.06e-05	4	65	2	20381594
Pubmed	SAFB1, an RBMX-binding protein, is a newly identified regulator of hepatic SREBP-1c gene.	RBMXL1 RBMX	2.06e-05	4	65	2	19403048
Pubmed	Targeting TRIM37-driven centrosome dysfunction in 17q23-amplified breast cancer.	ALMS1 UBR5 RBMX SVIL MGA	2.51e-05	184	65	5	32908313
Pubmed	Comparative interactome analysis of α-arrestin families in human and Drosophila.	SVIL NUMA1 DDX20 ARRDC2 TRIM3 NEDD4	2.68e-05	313	65	6	38270169
Pubmed	The human cytoplasmic dynein interactome reveals novel activators of motility.	ALMS1 TTC28 L3MBTL2 MEIOC UBR5 SVIL TMEM131 MGA DDX3X	2.88e-05	853	65	9	28718761
Pubmed	ADAMTS9 is a cell-autonomously acting, anti-angiogenic metalloprotease expressed by microvascular endothelial cells.	ADAMTS9 EMCN	3.43e-05	5	65	2	20093484
Pubmed	Activity-Based Probes for HECT E3 Ubiquitin Ligases.	UBR5 NEDD4	3.43e-05	5	65	2	28425671
Pubmed	Proteomic and biochemical studies of calcium- and phosphorylation-dependent calmodulin complexes in Mammalian cells.	UBR5 DDX3X	3.43e-05	5	65	2	17696464
Pubmed	Translational regulation of HIV-1 replication by HIV-1 Rev cellular cofactors Sam68, eIF5A, hRIP, and DDX3.	AGFG1 DDX3X	3.43e-05	5	65	2	21360055
Pubmed	Fibril treatment changes protein interactions of tau and α-synuclein in human neurons.	CDK13 SVIL NUMA1 XRCC1 TRIM3 DDX3X PRPH	4.02e-05	498	65	7	36634849
Pubmed	Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis.	SVIL CSMD1 ZIC1	5.43e-05	39	65	3	19010793
Pubmed	Interaction of LATS1 with SMAC links the MST2/Hippo pathway with apoptosis in an IAP-dependent manner.	ALMS1 L3MBTL2 SVIL EMD MGA	6.13e-05	222	65	5	35941108
Pubmed	A hypomorphic myogenin allele reveals distinct myogenin expression levels required for viability, skeletal muscle development, and sternum formation.	MYH8 MEF2C	7.18e-05	7	65	2	10075840
Pubmed	Comprehensive identification of phosphorylation sites in postsynaptic density preparations.	FGA LRRC7 DAGLA TRIM3 NEDD4	7.39e-05	231	65	5	16452087
Pubmed	Arginine methylation and ubiquitylation crosstalk controls DNA end-resection and homologous recombination repair.	L3MBTL2 RBMX DDX20 EMD MGA DDX3X PRPH	7.59e-05	551	65	7	34728620
Pubmed	A function for cyclin D1 in DNA repair uncovered by protein interactome analyses in human cancers.	L3MBTL2 NUMA1 MGA PRPH	9.09e-05	125	65	4	21654808
Pubmed	Cooperation of two ADAMTS metalloproteases in closure of the mouse palate identifies a requirement for versican proteolysis in regulating palatal mesenchyme proliferation.	ADAMTS9 EMCN	9.56e-05	8	65	2	21041365
Pubmed	CIP2A Interacts with TopBP1 and Drives Basal-Like Breast Cancer Tumorigenesis.	WWC3 UBR5	9.56e-05	8	65	2	34145035
Pubmed	Serine/Threonine Kinase 40 (Stk40) Functions as a Novel Regulator of Skeletal Muscle Differentiation.	MYH8 MEF2C	9.56e-05	8	65	2	27899448
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	UBE4B CDK13 RBMX SVIL NUMA1 PUM2 DDX20 RFX1	9.57e-05	774	65	8	15302935
Pubmed	PLK4 deubiquitination by Spata2-CYLD suppresses NEK7-mediated NLRP3 inflammasome activation at the centrosome.	ALMS1 PLK4 DDX3X	1.08e-04	49	65	3	31762063
Pubmed	Functional proteomics mapping of a human signaling pathway.	EPN3 UBR5 CDK13 RFX1 MGA DDX3X NEDD4	1.17e-04	591	65	7	15231748
Pubmed	Rev-ing up post-transcriptional HIV-1 RNA expression.	AGFG1 DDX3X	1.23e-04	9	65	2	21358275
Pubmed	Nuclear import of histone deacetylase 5 by requisite nuclear localization signal phosphorylation.	RBMX NUMA1 DDX20 EMD DDX3X	1.24e-04	258	65	5	21081666
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	ALMS1 TTC28 L3MBTL2 UBR5 RFX1 MGA	1.32e-04	418	65	6	34709266
Pubmed	Linc01232 promotes the metastasis of pancreatic cancer by suppressing the ubiquitin-mediated degradation of HNRNPA2B1 and activating the A-Raf-induced MAPK/ERK signaling pathway.	RBMX DDX3X	1.53e-04	10	65	2	32814086
Pubmed	U box proteins as a new family of ubiquitin-protein ligases.	UBE4B NEDD4	1.53e-04	10	65	2	11435423
Pubmed	Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.	UBE4B UBR5 LRRC7 GRM1 NEDD4	1.85e-04	281	65	5	28706196
Pubmed	Variants in LRRC7 lead to intellectual disability, autism, aggression and abnormal eating behaviors.	LRRC7 DDX3X	1.87e-04	11	65	2	39256359
Pubmed	Multiple interactions between the ESCRT machinery and arrestin-related proteins: implications for PPXY-dependent budding.	ARRDC2 NEDD4	1.87e-04	11	65	2	21191027
Pubmed	PCGF6 controls neuroectoderm specification of human pluripotent stem cells by activating SOX2 expression.	L3MBTL2 MGA	1.87e-04	11	65	2	35933409
Pubmed	Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.	L3MBTL2 UBR5 RBMX XRCC1 RFX1 MGA MEF2C TRIM3	1.92e-04	857	65	8	25609649
Pubmed	Proteomic characterization of chromosomal common fragile site (CFS)-associated proteins uncovers ATRX as a regulator of CFS stability.	RBMXL1 RBMX SVIL NUMA1 FGA EMD DDX3X	2.14e-04	652	65	7	31180492
Pubmed	SARS-CoV-2 Nsp6 damages Drosophila heart and mouse cardiomyocytes through MGA/MAX complex-mediated increased glycolysis.	L3MBTL2 UBR5 RBMX DDX20 EMD MGA DDX3X	2.24e-04	657	65	7	36180527
Pubmed	Single-cell transcriptomic profiling unveils dysregulation of cardiac progenitor cells and cardiomyocytes in a mouse model of maternal hyperglycemia.	MEF2C EMCN	2.24e-04	12	65	2	35970860
Pubmed	Replication of top markers of a genome-wide association study in multiple sclerosis in Spain.	CSMD1 ZIC1	2.24e-04	12	65	2	20944657
Pubmed	Cellular proteins and HIV-1 Rev function.	AGFG1 DDX3X	2.24e-04	12	65	2	19149558
Pubmed	Aerobic glycolysis tunes YAP/TAZ transcriptional activity.	WWC3 NUMA1 ZBTB18 DDX3X	2.46e-04	162	65	4	25796446
Pubmed	PRC1 and PRC2 are not required for targeting of H2A.Z to developmental genes in embryonic stem cells.	L3MBTL2 RFX1 MGA	2.51e-04	65	65	3	22496869
Pubmed	Charting the landscape of tandem BRCT domain-mediated protein interactions.	ALMS1 UBR5 CDK13 NUMA1 DDX20 EMD CUBN	2.52e-04	670	65	7	22990118
Pubmed	Vascular dimorphism ensured by regulated proteoglycan dynamics favors rapid umbilical artery closure at birth.	ADAMTS9 EMCN	2.65e-04	13	65	2	32909945
Pubmed	TRIP12 ubiquitination of glucocerebrosidase contributes to neurodegeneration in Parkinson's disease.	MYH8 MEIOC SVIL	2.74e-04	67	65	3	34644545
Pubmed	Identification of novel Ack1-interacting proteins and Ack1 phosphorylated sites in mouse brain by mass spectrometry.	SVIL LRRC7 NEDD4	2.74e-04	67	65	3	29254152
Pubmed	Human transcription factor protein interaction networks.	ALMS1 L3MBTL2 SVIL NUMA1 PUM2 EMD XRCC1 RFX1 MGA MEF2C	3.03e-04	1429	65	10	35140242
Pubmed	Defective excitation-contraction coupling is partially responsible for impaired contractility in hindlimb muscles of Stac3 knockout mice.	MYH8 MEF2C	3.08e-04	14	65	2	27184118
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	SHROOM4 ALMS1 ADAMTS9 CDK13 MGA MEX3B	3.20e-04	493	65	6	15368895
Pubmed	Fgf and Esrrb integrate epigenetic and transcriptional networks that regulate self-renewal of trophoblast stem cells.	NUMA1 XRCC1 MGA DDX3X	3.45e-04	177	65	4	26206133
Pubmed	Mammalian α arrestins link activated seven transmembrane receptors to Nedd4 family e3 ubiquitin ligases and interact with β arrestins.	ARRDC2 NEDD4	3.56e-04	15	65	2	23236378
Pubmed	Zbtb7b engages the long noncoding RNA Blnc1 to drive brown and beige fat development and thermogenesis.	DDX3X NEDD4	3.56e-04	15	65	2	28784777
Pubmed	Rp58 is essential for the growth and patterning of the cerebellum and for glutamatergic and GABAergic neuron development.	ZBTB18 ZIC1	3.56e-04	15	65	2	22513377
Pubmed	A comprehensive SARS-CoV-2-human protein-protein interactome reveals COVID-19 pathobiology and potential host therapeutic targets.	RBMXL1 RBMX SVIL FGA TMEM131 EMD	3.57e-04	503	65	6	36217030
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	RBMX NUMA1 AGFG1 EMD XRCC1 RFX1 MGA DDX3X	3.94e-04	954	65	8	36373674
Pubmed	Destabilization of Atoh1 by E3 Ubiquitin Ligase Huwe1 and Casein Kinase 1 Is Essential for Normal Sensory Hair Cell Development.	UBR5 RBMX MGA	3.97e-04	76	65	3	27542412
Pubmed	Splicing factor Srsf5 deletion disrupts alternative splicing and causes noncompaction of ventricular myocardium.	MYH8 EMCN	4.59e-04	17	65	2	34622152
Pubmed	LINC00240 in the 6p22.1 risk locus promotes gastric cancer progression through USP10-mediated DDX21 stabilization.	RBMX NUMA1	4.59e-04	17	65	2	37072811
Pubmed	MEF2C transcription factor controls chondrocyte hypertrophy and bone development.	MEF2C EMCN	4.59e-04	17	65	2	17336904
Pubmed	TRIM24 is an insulin-responsive regulator of P-bodies.	RBMXL1 RBMX PUM2	4.62e-04	80	65	3	35803934
Pubmed	The functional interactome of PYHIN immune regulators reveals IFIX is a sensor of viral DNA.	NUMA1 EMD XRCC1 RFX1 MGA	4.99e-04	349	65	5	25665578
Pubmed	Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain.	PXDN PUM2 TMEM131	5.14e-04	83	65	3	9039502
Pubmed	The nuclear import of the small GTPase Rac1 is mediated by the direct interaction with karyopherin alpha2.	RBMX DDX3X	5.16e-04	18	65	2	19961560
Pubmed	SPATA2-Mediated Binding of CYLD to HOIP Enables CYLD Recruitment to Signaling Complexes.	RBMX SVIL EMD MGA DDX3X	5.25e-04	353	65	5	27545878
Pubmed	Circular rapid amplification of cDNA ends for high-throughput extension cloning of partial genes.	CSF1R FGA CSMD1	5.33e-04	84	65	3	15203218
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	UBR5 RBMX SVIL NUMA1 EMD XRCC1 MGA DDX3X	6.28e-04	1024	65	8	24711643
Pubmed	E-cadherin interactome complexity and robustness resolved by quantitative proteomics.	EPN3 SVIL AGFG1 LRRC7 EMD DDX3X	6.57e-04	565	65	6	25468996
Pubmed	An expanded Oct4 interaction network: implications for stem cell biology, development, and disease.	EMD XRCC1 CUBN	6.73e-04	91	65	3	20362542
Pubmed	The Tbr2 Molecular Network Controls Cortical Neuronal Differentiation Through Complementary Genetic and Epigenetic Pathways.	ZBTB18 MEF2C	7.06e-04	21	65	2	27600842
Pubmed	The Tumor Suppressor CIC Directly Regulates MAPK Pathway Genes via Histone Deacetylation.	L3MBTL2 RBMX EMD RFX1 MGA DDX3X	7.73e-04	583	65	6	29844126
Pubmed	A new role for the calcineurin/NFAT pathway in neonatal myosin heavy chain expression via the NFATc2/MyoD complex during mouse myogenesis.	MYH8 MEF2C	7.76e-04	22	65	2	24301466
Pubmed	BDNF and NT4 play interchangeable roles in gustatory development.	CSF1R MGA	8.48e-04	23	65	2	24378336
Pubmed	ADAMTS9-Mediated Extracellular Matrix Dynamics Regulates Umbilical Cord Vascular Smooth Muscle Differentiation and Rotation.	ADAMTS9 EMCN	8.48e-04	23	65	2	26027930
Pubmed	Systematic identification of cancer cell vulnerabilities to natural killer cell-mediated immune surveillance.	UBR5 NUMA1 AGFG1 MGA	8.62e-04	226	65	4	31452512
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	FSIP2 L3MBTL2 NUMA1 XRCC1 RFX1 MGA	9.60e-04	608	65	6	36089195
Pubmed	Cellular localization and characterization of cytosolic binding partners for Gla domain-containing proteins PRRG4 and PRRG2.	PEX13 NEDD4	1.00e-03	25	65	2	23873930
Pubmed	Lmx1b controls the differentiation and migration of the superficial dorsal horn neurons of the spinal cord.	ZIC1 PRPH	1.00e-03	25	65	2	15229182
Pubmed	AP-2δ is a crucial transcriptional regulator of the posterior midbrain.	MYH8 MEF2C	1.00e-03	25	65	2	21858141
Pubmed	Characterization of SARS-CoV-2 proteins reveals Orf6 pathogenicity, subcellular localization, host interactions and attenuation by Selinexor.	L3MBTL2 UBR5 DDX20 MGA DDX3X	1.01e-03	408	65	5	33766124
Pubmed	System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes.	UBR5 NEDD4	1.09e-03	26	65	2	26949039
Pubmed	Interactome of the negative regulator of nuclear import BRCA1-binding protein 2.	NUMA1 PHLPP1	1.09e-03	26	65	2	25820252
Pubmed	Molecular Characterization of the Oncogene BTF3 and Its Targets in Colorectal Cancer.	RBMX SVIL NUMA1 EMD XRCC1 DDX3X	1.12e-03	626	65	6	33644029
Pubmed	Characterization of gene regulation and protein interaction networks for Matrin 3 encoding mutations linked to amyotrophic lateral sclerosis and myopathy.	RBMXL1 RBMX DDX3X	1.14e-03	109	65	3	29511296
Pubmed	Interactome analyses revealed that the U1 snRNP machinery overlaps extensively with the RNAP II machinery and contains multiple ALS/SMA-causative proteins.	RBMX NUMA1 DDX20 DDX3X	1.14e-03	244	65	4	29884807
Pubmed	Identification of proteins associated with ligand-activated estrogen receptor α in human breast cancer cell nuclei by tandem affinity purification and nano LC-MS/MS.	RBMX NUMA1 EMD DDX3X	1.16e-03	245	65	4	21182205
Pubmed	Nuclear organization of nucleotide excision repair is mediated by RING1B dependent H2A-ubiquitylation.	RBMXL1 RBMX DDX3X	1.23e-03	112	65	3	28416769
Pubmed	Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant.	UBR5 LRRC7 DAGLA MTSS2 PRPH	1.27e-03	430	65	5	32581705
Pubmed	Maintenance of silent chromatin through replication requires SWI/SNF-like chromatin remodeler SMARCAD1.	L3MBTL2 NUMA1 DDX3X	1.36e-03	116	65	3	21549307
Interaction	BTRC interactions	CSF1R ALMS1 BCL2L11 PHF19 UBE4B RBMX PHLPP1 EMD XRCC1 PLK4 DDX3X NEDD4	2.96e-06	775	61	12	int:BTRC
Interaction	FBXW11 interactions	CSF1R BCL2L11 RBMXL1 UBE4B UBR5 RBMX PLK4 DDX3X MTSS2	1.18e-05	473	61	9	int:FBXW11
Interaction	PAIP2 interactions	UBR5 RBMX PUM2 MEX3B	3.96e-05	63	61	4	int:PAIP2
Interaction	RNF43 interactions	ALMS1 TTC28 MEIOC UBR5 SVIL TMEM131 LRRC7 EMD	4.19e-05	427	61	8	int:RNF43
Interaction	TRIM52 interactions	ALMS1 L3MBTL2 MEIOC MGA NEDD4	5.13e-05	133	61	5	int:TRIM52
Interaction	LATS1 interactions	MYH8 ALMS1 WWC3 L3MBTL2 SVIL EMD MGA NEDD4	5.18e-05	440	61	8	int:LATS1
Interaction	POU5F1 interactions	L3MBTL2 UBR5 NUMA1 DDX20 EMD XRCC1 CUBN MGA NEDD4	6.13e-05	584	61	9	int:POU5F1
Interaction	CNOT9 interactions	ALMS1 PUM2 TMEM131 DDX20 MGA MEX3B	6.97e-05	231	61	6	int:CNOT9
Interaction	CHAMP1 interactions	L3MBTL2 PHF19 NUMA1 MGA MTSS2	8.53e-05	148	61	5	int:CHAMP1
Interaction	LITAF interactions	EPN3 PUM2 ZIC1 NEDD4	8.71e-05	77	61	4	int:LITAF
Cytoband	4q28	FGA PLK4	7.06e-05	9	65	2	4q28
GeneFamily	I-BAR domain containing	BAIAP2L2 MTSS2	6.58e-05	5	47	2	1287
Coexpression	GSE45365_WT_VS_IFNAR_KO_BCELL_MCMV_INFECTION_UP	ALMS1 MEIOC PHF19 DSPP CDK13 NUMA1 XRCC1	3.70e-07	184	65	7	M9988
Coexpression	GSE45365_HEALTHY_VS_MCMV_INFECTION_CD11B_DC_UP	ALMS1 MEIOC DSPP XRCC1 ARRDC2 TRIM3	7.53e-06	189	65	6	M9978
Coexpression	NAKAYA_PLASMACYTOID_DENDRITIC_CELL_FLUMIST_AGE_18_50YO_7DY_UP	SP4 BCL2L11 UBE4B UBR5 CDK13 NUMA1 PUM2 PEX13 TMEM131 ZBTB18 PLK4 MEF2C	3.85e-05	1215	65	12	M41122
Coexpression	DACOSTA_UV_RESPONSE_VIA_ERCC3_DN	TTC28 UBR5 CDK13 AGFG1 PHLPP1 PUM2 TMEM131 SUCO ZBTB18 NEDD4	4.61e-05	856	65	10	M4500
ToppCell	Children_(3_yrs)-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	SHROOM4 PXDN WWC3 PHLPP1 EMCN NEDD4	3.52e-07	190	65	6	0a351609a72fd638c84b2435782e312ee6a33aac
ToppCell	Brain_organoid-organoid_Velasco_nature-6_mon-Neuronal-Immature_CPNs\|6_mon / Sample Type, Dataset, Time_group, and Cell type.	TTC28 SRRM4 LRRC7 C1orf216 ZBTB18 MEX3B	4.48e-07	198	65	6	4e598aab92141e7d32ec963291ddeed14a21beba
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-3m\|organoid_Tanaka_cellReport / Sample Type, Dataset, Time_group, and Cell type.	SRRM4 LRRC7 C1orf216 ZBTB18 MEX3B MEF2C	4.75e-07	200	65	6	e4f0bb57be1112869c7068d0a789c2b802a442dd
ToppCell	PND10-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte-Pericyte_G2M\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	L3MBTL2 PHF19 DAGLA PLK4 PRPH	5.75e-06	175	65	5	15c69dd5635c9251c535f1e22467712e9667ae92
ToppCell	droplet-Liver-HEPATOCYTES-1m-Endothelial-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PXDN ADAMTS9 MEF2C EMCN MTSS2	7.53e-06	185	65	5	742350093d90f96735dc73e3360cdd749bae63fd
ToppCell	356C-Endothelial_cells-Endothelial-E-\|356C / Donor, Lineage, Cell class and subclass (all cells)	SHROOM4 TSPAN11 PXDN CUBN EMCN	7.73e-06	186	65	5	2e024097ee361eeb1d855a4edb8ac8cdad35da06
ToppCell	356C-Endothelial_cells-Endothelial-E\|356C / Donor, Lineage, Cell class and subclass (all cells)	SHROOM4 TSPAN11 PXDN CUBN EMCN	7.73e-06	186	65	5	c3449e54454009973818fc1101933c6f0168258c
ToppCell	Adult-Endothelial-capillary_endothelial_cell_(Cap1)-D175\|Adult / Lineage, Cell type, age group and donor	SHROOM4 PXDN TTC28 EMCN NEDD4	7.93e-06	187	65	5	f3548817f2fded5978137bb252cb628ac199e4f6
ToppCell	Control-Endothelial-VE_Capillary_B\|Control / Disease state, Lineage and Cell class	SHROOM4 PXDN TTC28 ADAMTS9 EMCN	8.79e-06	191	65	5	322237793a1278bafb14e63cab688b353e352dcc
ToppCell	LPS_only-Endothelial-Endothelial-Vein\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SHROOM4 SYT16 ADAMTS9 MEF2C NEDD4	9.01e-06	192	65	5	52acaecd3703166f5ce3b328aff7c82bd142fee4
ToppCell	COVID-19-Endothelial_cells-Inflamed_endothelial_cells\|COVID-19 / group, cell type (main and fine annotations)	SHROOM4 PXDN ADAMTS9 EMCN NEDD4	9.24e-06	193	65	5	979ebefa527f86bebeea5d94e626ee6c1cc7d53b
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SYT16 SRRM4 LRRC7 CSMD1 MEF2C	9.96e-06	196	65	5	676c56b44ac29f7baecb62f49bb8597cc74c0a88
ToppCell	Brain_organoid-organoid_Velasco_nature-6_mon-Neuronal-CPNs\|6_mon / Sample Type, Dataset, Time_group, and Cell type.	SYT16 LRRC7 C1orf216 ZBTB18 MEF2C	9.96e-06	196	65	5	c9e7ac34993c873de4f198cdae77dcf099731532
ToppCell	3'-Parenchyma_lung-Endothelial-Blood_vessel_EC-capillary_endothelial_cell-EC_general_capillary-EC_general_capillary_L.2.0.2.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SHROOM4 PXDN ADAMTS9 MEF2C EMCN	1.02e-05	197	65	5	15d1e0dffee8f5ba8cee37adfbfa0551a0cd5e15
ToppCell	Somatosensory_Cortex_(S1)-Neuronal\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SYT16 SRRM4 LRRC7 CSMD1 MEF2C	1.05e-05	198	65	5	c01091ef18e096d792ea2a7a715764a5b215355f
ToppCell	primary_auditory_cortex_(A1C)-Neuronal\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SYT16 SRRM4 LRRC7 CSMD1 MEF2C	1.05e-05	198	65	5	6d18b45eda4014759e6dd282d78ffd28df8a6044
ToppCell	Bronchus_Control_(B.)-Endothelial-TX\|Bronchus_Control_(B.) / Sample group, Lineage and Cell type	SYT16 MEIOC SRRM4 LRRC7 EMCN	1.05e-05	198	65	5	feac39036b5c0ab97b524cc366286942d136d42f
ToppCell	Brain_organoid-organoid_Velasco_nature-3_mon-Neuronal\|3_mon / Sample Type, Dataset, Time_group, and Cell type.	SRRM4 LRRC7 C1orf216 ZBTB18 MEF2C	1.05e-05	198	65	5	a0032e3ed259e39324a659490b9d340c5d9ba0fc
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SYT16 SRRM4 LRRC7 CSMD1 MEF2C	1.05e-05	198	65	5	0ff30edfd3c133a42e8cb96e1631a1143215f808
ToppCell	Bronchus_Control_(B.)-Endothelial-TX-Bronchial_vessel\|Bronchus_Control_(B.) / Sample group, Lineage and Cell type	SYT16 MEIOC SRRM4 LRRC7 EMCN	1.05e-05	198	65	5	dcf334d13e5b0018fee24febccfef91c9e17843b
ToppCell	Brain_organoid-organoid_Paulsen_bioRxiv-3.5_mon-Neuronal\|3.5_mon / Sample Type, Dataset, Time_group, and Cell type.	SRRM4 LRRC7 C1orf216 ZBTB18 MEF2C	1.07e-05	199	65	5	0cd3e4e0fba000c996feaf012ff32198e1048c9d
ToppCell	Parenchymal-10x3prime_v2-Endothelial-Endothelia_vascular-VE_systemic_arterial\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	SHROOM4 TSPAN11 ADAMTS9 MEF2C TRIM3	1.10e-05	200	65	5	a8b59e6fe04271fef61db911a286b5c48438bb84
ToppCell	Neuronal\|World / cells hierarchy compared to all cells using T-Statistic	SYT16 SRRM4 LRRC7 CSMD1 MEF2C	1.10e-05	200	65	5	48d801219bc771d6c7e151dc88ca4c179988de85
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-3m-Neuronal-Cortical_neuron\|3m / Sample Type, Dataset, Time_group, and Cell type.	SRRM4 LRRC7 C1orf216 ZBTB18 MEF2C	1.10e-05	200	65	5	c248233b004f8ef0bab3c65ecfe295887966f2ee
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-3m-Neuronal\|3m / Sample Type, Dataset, Time_group, and Cell type.	SRRM4 LRRC7 C1orf216 ZBTB18 MEF2C	1.10e-05	200	65	5	af99d90070e2933fd2e9512590c6cf3bd6e15539
ToppCell	Brain_organoid-organoid_Paulsen_bioRxiv-3.5_mon-Neuronal-CPNs\|3.5_mon / Sample Type, Dataset, Time_group, and Cell type.	TTC28 LRRC7 C1orf216 ZBTB18 MEF2C	1.10e-05	200	65	5	71cbefbef4ae5bbb5f6e419914f4b3b3b5a5f9e3
ToppCell	TCGA-Skin-Metastatic-Melanoma-Skin_Cutaneous_Melanoma-3\|TCGA-Skin / Sample_Type by Project: Shred V9	TTC28 PHLPP1 EMCN MTSS2	8.60e-05	159	65	4	fb222c42f66901852b01cec073ec0732245ee973
ToppCell	Hippocampus-Neuronal-Inhibitory-iN2(Gad1Gad2)-Tox\|Hippocampus / BrainAtlas - Mouse McCarroll V32	FSIP2 MSH4 BAIAP2L2	1.13e-04	64	65	3	bf923a66b17e717b8d3817b9d0e201b82a7e4a88
ToppCell	Hippocampus-Neuronal-Inhibitory-iN2(Gad1Gad2)-Tox-Inhibitory_Gad1Gad2_Cplx3.Tox_(Interneuron,_lacunosum_oriens1?)\|Hippocampus / BrainAtlas - Mouse McCarroll V32	FSIP2 MSH4 BAIAP2L2	1.13e-04	64	65	3	a3e852600c53b11175eb579e92962fa711f5678b
ToppCell	Hippocampus-Neuronal-Inhibitory-iN2(Gad1Gad2)-Tox-Inhibitory_Gad1Gad2_Cplx3.Tox_(Interneuron,_lacunosum_oriens1?)-\|Hippocampus / BrainAtlas - Mouse McCarroll V32	FSIP2 MSH4 BAIAP2L2	1.13e-04	64	65	3	f8f43ad9354c786b418bac54614f96f50e8bea68
ToppCell	AT1-AT2_cells-Cryobiopsy_01\|World / lung cells shred on cell class, cell subclass, sample id	EPN3 FSIP2 PXDN SRRM4	1.16e-04	172	65	4	0be41df5d35d818deb7316ac21c9366eb4b7bfd1
ToppCell	COVID-19-kidney-AQP1+SLC14A1+EC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	TTC28 ADAMTS9 MEF2C EMCN	1.36e-04	179	65	4	1ce8d18f63e8dd2d3db41fbeca4601bd3b305fba
ToppCell	metastatic_Brain-Endothelial_cells-Lymphatic_ECs\|metastatic_Brain / Location, Cell class and cell subclass	ADAMTS9 SVIL ZIC1 EMCN	1.36e-04	179	65	4	56fe381ffbaba3a4f2f587a3e367b0d11fbd4a2a
ToppCell	COVID-19-Endothelial_cells-Endothelial_cells_(other)\|COVID-19 / group, cell type (main and fine annotations)	SHROOM4 PXDN ADAMTS9 EMCN	1.42e-04	181	65	4	26eb4ee57a70dbf54e096b73129fda9dfda1f6ec
ToppCell	COVID-19-Endothelial_cells-Capillary_endothelial_cells\|COVID-19 / group, cell type (main and fine annotations)	SHROOM4 PXDN EMCN NEDD4	1.42e-04	181	65	4	c5f9c92af1384d9089c65afdf41c6feb8345a3ae
ToppCell	Adult-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)-D175\|Adult / Lineage, Cell type, age group and donor	SNPH PXDN EMCN NEDD4	1.45e-04	182	65	4	8b4a07ebd7a133a33ef333cfa29d12c4f3d4d9ac
ToppCell	COVID-19-Heart-Fib_+_EC_+_Pericyte\|COVID-19 / Disease (COVID-19 only), tissue and cell type	MYH8 PXDN ADAMTS9 EMCN	1.45e-04	182	65	4	fbd5e332df73bf7141c822fa67b76367dc962017
ToppCell	5'-Parenchyma_lung-Endothelial-Blood_vessel_EC-pulmonary_artery_endothelial_cell-EC_arterial-EC_arterial_L.2.4.1.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SHROOM4 PXDN CUBN MEF2C	1.48e-04	183	65	4	ce8be9418b473ea94ec806edc7a2078cc30c1703
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_Arw_fibro_(16)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	TSPAN11 SVIL LRRC7 CSMD1	1.54e-04	185	65	4	7dcdc009c5681ee05dd18968f7e85c3403fe34af
ToppCell	LPS-IL1RA-Endothelial-Endothelial-Activated_Gen_Cap\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SHROOM4 ADAMTS9 MEF2C NEDD4	1.54e-04	185	65	4	808d5e880069aff8866cd2c733b9fe568a37701f
ToppCell	COPD-Endothelial-VE_Peribronchial\|World / Disease state, Lineage and Cell class	SHROOM4 PXDN ADAMTS9 EMCN	1.54e-04	185	65	4	4abe04198ab5047c211f8d09cdb9650fa52a3cd6
ToppCell	COPD-Endothelial-VE_Peribronchial\|COPD / Disease state, Lineage and Cell class	SHROOM4 PXDN ADAMTS9 EMCN	1.57e-04	186	65	4	23c7d0e8372a71546d687278b985f761d282f92f
ToppCell	facs-Brain_Non-Myeloid-Striatum_-18m-Neuronal-interneuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GRM1 ZBTB18 ZIC1 MTSS2	1.57e-04	186	65	4	a1ab273b01971d6a892912560d387685dd657179
ToppCell	10x3'2.3-week_17-19-Endothelial-stroma-proliferating_EC\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	SHROOM4 TTC28 ADAMTS9 EMCN	1.57e-04	186	65	4	a844d4f79e0ad5d6c60a4488ffd8f4f21b7eed04
ToppCell	LV-10._Endothelium_II\|World / Chamber and Cluster_Paper	SHROOM4 ADAMTS9 EMCN NEDD4	1.60e-04	187	65	4	7876dcb4800c2e54874df3d933efb79307a64a97
ToppCell	facs-Brain_Non-Myeloid-Striatum_-18m-Neuronal-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GRM1 ZBTB18 ZIC1 MTSS2	1.60e-04	187	65	4	ef3c85c01bc3da408ae288b6e3096ad888a12e63
ToppCell	Control-Endothelial-VE_Capillary_A\|Control / Disease state, Lineage and Cell class	SHROOM4 PXDN EMCN NEDD4	1.60e-04	187	65	4	54d7588172ac145ff5045ad9771636729ca3f0ca
ToppCell	Control-Endothelial-VE_Peribronchial\|Control / Disease state, Lineage and Cell class	SHROOM4 PXDN ADAMTS9 EMCN	1.64e-04	188	65	4	f5b7dbc89f992c13280d36a34935be83906b1bc0
ToppCell	nucseq-Endothelial-Endothelial_Vascular-Endothelial_capillary-CAP2\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	SHROOM4 PXDN EMCN NEDD4	1.67e-04	189	65	4	b6b4da51bc7f2c13a2f940540fdc61027d084835
ToppCell	LPS_only-Endothelial-Endothelial-Artery\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SHROOM4 TSPAN11 CSMD1 MEF2C	1.67e-04	189	65	4	b028466fcd36fdeceec752e55a24286a1cd62ae4
ToppCell	COVID-19-Endothelial_cells-Endothelial_cells_(general)\|COVID-19 / group, cell type (main and fine annotations)	SHROOM4 TTC28 ADAMTS9 EMCN	1.71e-04	190	65	4	812e11314c76c0179fbe5a9bea29b41ce5cbc93d
ToppCell	facs-GAT-Fat-3m\|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TSPAN11 CSF1R SVIL DDX3X	1.71e-04	190	65	4	1d92be1b41cff59e834a9d28868f554bd1f3e471
ToppCell	human_hepatoblastoma-Endothelial_cells\|World / Sample and Cell Type and Tumor Cluster (all cells)	PXDN ADAMTS9 MEF2C EMCN	1.71e-04	190	65	4	8d6ef93d69e96cd6921816d152bea3b0710cf147
ToppCell	COVID-19-Endothelial_cells\|COVID-19 / group, cell type (main and fine annotations)	SHROOM4 TTC28 ADAMTS9 EMCN	1.71e-04	190	65	4	9fbd92cd6d4683b2490504d29c43cf42020433d4
ToppCell	Endothelial-A-Myositis-ILD_01\|World / lung cells shred on cell class, cell subclass, sample id	SHROOM4 PXDN ADAMTS9 EMCN	1.74e-04	191	65	4	f702dfe88a9b04091dae87df61b2b4f43525f86a
ToppCell	Control-Endothelial-VE_Capillary_B\|World / Disease state, Lineage and Cell class	SHROOM4 TTC28 EMCN NEDD4	1.74e-04	191	65	4	c672c8e28d06d555335976b3f8bd2ea6d3b34aae
ToppCell	Mesenchymal-vascular_smooth_muscle_cell\|World / Lineage, Cell type, age group and donor	PXDN ADAMTS9 CSMD1 MEF2C	1.74e-04	191	65	4	fd89fbc62aa1c73e0f659991e3bd726a0c97bd68
ToppCell	COVID-19-kidney-AQP1+PLVAP+EC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	TTC28 ADAMTS9 MEF2C EMCN	1.78e-04	192	65	4	27ff3621e177e7932dd44dd6baa81551ea75a874
ToppCell	human_hepatoblastoma-Endothelial_cells\|human_hepatoblastoma / Sample and Cell Type and Tumor Cluster (all cells)	PXDN ADAMTS9 MEF2C EMCN	1.78e-04	192	65	4	e09f609fed033a25baacaf4a07bbbae1076da366
ToppCell	RA-09._Endothelium_I\|RA / Chamber and Cluster_Paper	SHROOM4 ADAMTS9 MEF2C EMCN	1.78e-04	192	65	4	8a1b1c3e83a68ad74f8f4eb00455c9e41aa57cfc
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	MYH8 CUBN CSMD1 BAIAP2L2	1.78e-04	192	65	4	3e1a4cb0d83efd502c8613d41a1692bdda5860ed
ToppCell	nucseq-Endothelial-Endothelial_Vascular-Endothelial_capillary\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	SHROOM4 TTC28 EMCN NEDD4	1.81e-04	193	65	4	f582e939e3e08a8a3f71deec78c33715be8faa51
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Lymphocytic-Lymphocytic_B-B_cell-B_c02-MS4A1-CD27\|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)	BCL2L11 AGFG1 PHLPP1 MEF2C	1.81e-04	193	65	4	08696a99309f5b088692ddac8cca35413b5e810d
ToppCell	droplet-Liver-LIVER_HEP-30m-Endothelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TTC28 MEF2C EMCN MTSS2	1.81e-04	193	65	4	826b8dd801298b3e0cd76232feae5a14026b8806
ToppCell	RV-10._Endothelium_II\|RV / Chamber and Cluster_Paper	SHROOM4 ADAMTS9 EMCN NEDD4	1.81e-04	193	65	4	01c2df9206f1527c578e808978e58196c35e72f5
ToppCell	LPS-antiTNF-Endothelial-Endothelial\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SHROOM4 MEF2C EMCN NEDD4	1.81e-04	193	65	4	02f633b016ab19bfa65bfd0cf32f000549a62148
ToppCell	droplet-Liver-LIVER_HEP-30m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TTC28 MEF2C EMCN MTSS2	1.81e-04	193	65	4	87d3a577d37fb0cb4b6313c596310de452bc3872
ToppCell	IPF-Endothelial-VE_Capillary_B\|World / Disease state, Lineage and Cell class	SHROOM4 PXDN ADAMTS9 EMCN	1.81e-04	193	65	4	d7750a7575ef257963b7f1c64fa67c52dbff797b
ToppCell	LPS-antiTNF-Endothelial\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SHROOM4 MEF2C EMCN NEDD4	1.81e-04	193	65	4	5122b1ffba42de190061be34ecdc6176f84e56a3
ToppCell	Fetal_29-31_weeks-Endothelial-capillary_endothelial_cell_(Cap1)-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	PXDN ADAMTS9 MEF2C EMCN	1.81e-04	193	65	4	ad2df9b77999780860141be6ec366afc0172a331
ToppCell	COPD-Endothelial\|COPD / Disease state, Lineage and Cell class	SHROOM4 PXDN ADAMTS9 EMCN	1.81e-04	193	65	4	093b28dcccb5841c995d0b33fae0efd6b88f97e0
ToppCell	droplet-Liver-LIVER_HEP-30m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TTC28 MEF2C EMCN MTSS2	1.81e-04	193	65	4	d485634c564b268e344b6a2863c26f6adaec9e38
ToppCell	RV-10._Endothelium_II\|World / Chamber and Cluster_Paper	SHROOM4 ADAMTS9 EMCN NEDD4	1.81e-04	193	65	4	2531266bc57339d4e2b22a88817008e32b8c1598
ToppCell	nucseq-Endothelial-Endothelial_Vascular-Endothelial_capillary-CAP1\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	SHROOM4 TTC28 EMCN NEDD4	1.81e-04	193	65	4	ad3f4fcc8e2816d696cbcde744dc16500e51ccac
ToppCell	Children_(3_yrs)-Endothelial-capillary_endothelial_cell_(Cap1)\|Children_(3_yrs) / Lineage, Cell type, age group and donor	SHROOM4 TTC28 EMCN NEDD4	1.85e-04	194	65	4	71ac69cdf7a08ca3ddfb5b492b14ac56b6cd5e5d
ToppCell	LPS-IL1RA-Endothelial\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SHROOM4 MEF2C EMCN NEDD4	1.85e-04	194	65	4	43f92b0533e26633dc94cce554045d641ef8fd76
ToppCell	COPD-Endothelial-VE_Capillary_B\|World / Disease state, Lineage and Cell class	SHROOM4 PXDN ADAMTS9 EMCN	1.85e-04	194	65	4	68705a6eca947c5b42b943d5224a7aef2a744007
ToppCell	IPF-Endothelial-VE_Capillary_B\|IPF / Disease state, Lineage and Cell class	SHROOM4 PXDN ADAMTS9 EMCN	1.85e-04	194	65	4	169a304d5c13f08c39fad4116f093bc4a0765e9d
ToppCell	IPF-Endothelial\|IPF / Disease state, Lineage and Cell class	SHROOM4 PXDN ADAMTS9 EMCN	1.85e-04	194	65	4	9591993aa2dcba3d09a0f1ea8b8f2439c26482d6
ToppCell	LPS-IL1RA-Endothelial-Endothelial\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SHROOM4 MEF2C EMCN NEDD4	1.85e-04	194	65	4	1d39d968730a7e85b6161c1c8a6bd38afe9bcad7
ToppCell	LPS_only-Endothelial\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SHROOM4 MEF2C EMCN NEDD4	1.85e-04	194	65	4	58f069efdefa0366033764446b9d6ffd4a17807e
ToppCell	COPD-Endothelial-VE_Capillary_B\|COPD / Disease state, Lineage and Cell class	SHROOM4 PXDN ADAMTS9 EMCN	1.85e-04	194	65	4	18b7f901c12ca4f21f9a1eafd092aefe4d668b6d
ToppCell	LPS_only-Endothelial-Endothelial\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SHROOM4 MEF2C EMCN NEDD4	1.85e-04	194	65	4	bfd92ec75facb0ba55c31e5f2e089d983b3d0169
ToppCell	TCGA-Head_and_Esophagus-Primary_Tumor-Head_and_Neck_Carcinoma-Squamous_Cell_Carcinoma-8\|TCGA-Head_and_Esophagus / Sample_Type by Project: Shred V9	MYH8 CSF1R PXDN MEF2C	1.85e-04	194	65	4	55b97095a7a17a312c616703d291738a0f806339
ToppCell	IPF-Endothelial-VE_Peribronchial\|World / Disease state, Lineage and Cell class	SHROOM4 PXDN ADAMTS9 EMCN	1.88e-04	195	65	4	120296531bbc8080dcabacbd64733cc1dc34603a
ToppCell	LPS_only-Endothelial-Endothelial-Activated_Gen_Cap\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SHROOM4 ADAMTS9 MEF2C NEDD4	1.88e-04	195	65	4	56efeb58df19f357d7d5ce87348d4f196a595421
ToppCell	IPF-Endothelial-VE_Peribronchial\|IPF / Disease state, Lineage and Cell class	SHROOM4 PXDN ADAMTS9 EMCN	1.88e-04	195	65	4	2c3ad3cb79f11119ac69c413a938d21199145040
ToppCell	COVID-19-Heart-EC_1\|Heart / Disease (COVID-19 only), tissue and cell type	SHROOM4 ADAMTS9 MEF2C EMCN	1.88e-04	195	65	4	50a193475db1bb1e05b8590225a553688c372c14
ToppCell	Tracheal-10x5prime-Endothelial-Endothelia_vascular-VE_capillary\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	ADAMTS9 GRM1 MEF2C EMCN	1.92e-04	196	65	4	f0b106078212be1d0938f545707a004a1e830857
ToppCell	COVID-19-lung-Capillary_Aerocytes\|COVID-19 / Disease (COVID-19 only), tissue and cell type	PXDN WWC3 EMCN NEDD4	1.92e-04	196	65	4	49cc0a2b9739abad61dff7292ea0b14d28ff35c4
ToppCell	Bronchial-10x5prime-Immune_Myeloid-Macrophage_other-Macro_AW_CX3CR1\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	CSF1R MSH4 PLK4 MEF2C	1.92e-04	196	65	4	b15812354128c12a588d79ef449d787e74835f3b
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TTC28 MEF2C EMCN NEDD4	1.92e-04	196	65	4	b8f89a50114932c08fc5daac4b549adfe9df8e66
ToppCell	nucseq-Endothelial-Endothelial_Vascular\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	SHROOM4 TTC28 EMCN NEDD4	1.92e-04	196	65	4	686533fd3fba8e4df96b9dd1307e870e89db4332
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TTC28 MEF2C EMCN NEDD4	1.92e-04	196	65	4	145fcf73deba9638b391a1af6c39fa205dc9829f
ToppCell	COVID-19-lung-Capillary_Aerocytes\|lung / Disease (COVID-19 only), tissue and cell type	SHROOM4 PXDN EMCN NEDD4	1.92e-04	196	65	4	4ac4073380d939a73cec7413e9f3f5ef616d2924
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Endothelial\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TTC28 MEF2C EMCN NEDD4	1.92e-04	196	65	4	d0ff1082898d2db47c88d2678466514e9e9193d3
ToppCell	3'-Broncho-tracheal-Endothelial-Blood_vessel_EC-vein_endothelial_cell-EC_venous_systemic-EC_venous_systemic_L.2.2.0.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PXDN ADAMTS9 MEF2C EMCN	1.96e-04	197	65	4	78bc83cd5546c7dd128e6791acda97f55089bc1c
ToppCell	COVID-19-lung-Capillary_1\|lung / Disease (COVID-19 only), tissue and cell type	SHROOM4 TTC28 EMCN NEDD4	1.96e-04	197	65	4	7e86ff9dafcbaaa7464d61484dd48bfeb7eae6e4
ToppCell	nucseq-Endothelial\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	TTC28 ADAMTS9 EMCN NEDD4	1.96e-04	197	65	4	ebf9be068eaa658493fa7884fd19f34642922acb
ToppCell	ASK452-Endothelial-Endothelium\|ASK452 / Donor, Lineage and Cell class of Lung cells from Dropseq	SHROOM4 PXDN ADAMTS9 EMCN	2.00e-04	198	65	4	e282769f5fa1765bcce79a0ed9d761bf2e14b012
Drug	Acacetin [480-44-4]; Down 200; 14uM; MCF7; HT_HG-U133A	CSF1R ALMS1 TTC28 NUMA1 PLK4 ZIC1	1.66e-05	192	64	6	6044_DN
Drug	Azaguanine-8 [134-58-7]; Down 200; 26.2uM; MCF7; HT_HG-U133A	ALMS1 UBE4B NUMA1 AGFG1 PLK4 DDX3X	1.81e-05	195	64	6	7444_DN
Drug	Hydralazine hydrochloride [304-20-1]; Up 200; 20.4uM; MCF7; HT_HG-U133A	FGA GRM1 ZBTB18 DAGLA MEF2C MTSS2	1.81e-05	195	64	6	4746_UP
Drug	Merbromin [129-16-8]; Up 200; 5uM; PC3; HT_HG-U133A	FGA GRM1 MEF2C TRIM3 DDX3X MTSS2	1.87e-05	196	64	6	3700_UP
Drug	Glibenclamide [10238-21-8]; Up 200; 8uM; MCF7; HT_HG-U133A	SNPH TTC28 DSPP CDK13 PLK4 EMCN	1.98e-05	198	64	6	3163_UP
Drug	alpha-estradiol; Down 200; 0.01uM; MCF7; HG-U133A	ALMS1 UBE4B UBR5 CDK13 DAGLA PRPH	2.03e-05	199	64	6	122_DN
Drug	Folinic acid calcium salt [6035-45-6]; Down 200; 7.8uM; MCF7; HT_HG-U133A	CSF1R TTC28 DSPP NUMA1 TRIM3 DDX3X	2.03e-05	199	64	6	4725_DN
Disease	invasive ductal carcinoma (is_implicated_in)	UBR5 XRCC1	2.59e-04	11	65	2	DOID:3008 (is_implicated_in)
Disease	glycodeoxycholate measurement	SVIL CSMD1	4.27e-04	14	65	2	EFO_0010493
Disease	nasopharynx carcinoma (is_implicated_in)	CSF1R XRCC1	4.93e-04	15	65	2	DOID:9261 (is_implicated_in)
Disease	T-Cell Lymphoma	MGA DDX3X	5.62e-04	16	65	2	C0079772
Disease	lung cancer (is_implicated_in)	CSF1R XRCC1 DAGLA	5.91e-04	74	65	3	DOID:1324 (is_implicated_in)
Disease	urinary albumin to creatinine ratio	BCL2L11 NUMA1 CUBN MGA	6.64e-04	179	65	4	EFO_0007778
Disease	Abnormality of refraction	TPRA1 PHF19 ADAMTS9 DAGLA MEX3B DDX3X NEDD4	6.89e-04	673	65	7	HP_0000539
Disease	Epilepsy, Cryptogenic	GRM1 MEF2C DDX3X	7.98e-04	82	65	3	C0086237
Disease	Awakening Epilepsy	GRM1 MEF2C DDX3X	7.98e-04	82	65	3	C0751111
Disease	Aura	GRM1 MEF2C DDX3X	7.98e-04	82	65	3	C0236018
Disease	anti-Mullerian hormone measurement	TTC28 MEF2C	8.85e-04	20	65	2	EFO_0004769
Disease	influenza A (H1N1)	WWC3 NUMA1 AGFG1	9.48e-04	87	65	3	EFO_1001488
Disease	platelet crit	SP4 TTC28 MEIOC CDK13 SVIL PHLPP1 CUBN MEF2C	1.13e-03	952	65	8	EFO_0007985
Disease	obsolete Mendelian syndromes with cleft lip/palate	SVIL LRRC7	1.17e-03	23	65	2	MONDO_0015335
Disease	lymphocyte count	ALMS1 BCL2L11 TTC28 PHF19 UBE4B CDK13 PHLPP1 PEX13 ARRDC2 MEX3B	1.30e-03	1464	65	10	EFO_0004587
Disease	alpha-linolenic acid measurement	CSMD1 DAGLA	1.39e-03	25	65	2	EFO_0007759
Disease	colon adenocarcinoma (is_implicated_in)	CSF1R UBR5	1.50e-03	26	65	2	DOID:234 (is_implicated_in)
Disease	Hodgkins lymphoma, multiple myeloma, non-Hodgkins lymphoma	BCL2L11 PHLPP1	1.74e-03	28	65	2	EFO_0000183, EFO_0001378, EFO_0005952
Disease	Epilepsy	GRM1 MEF2C DDX3X	1.81e-03	109	65	3	C0014544
Disease	opioid dependence	CSMD1 MEF2C ZIC1 EMCN	1.87e-03	237	65	4	EFO_0005611

Protein segments in the cluster

Peptide	Gene	Start	Entry
FSGNTALETAYSSTN	CSMD1	2216	Q96PZ7
YSRSRGSPSSYNSSS	EPN3	176	Q9H201
ASSSSYSNREKASIF	ALMS1	1891	Q8TCU4
NGYASSSLSIDSRSS	C1orf216	111	Q8TAB5
SSLLSRSSSGYFSFD	BCL2L11	86	O43521
SDNNSSSRGDASYNS	DSPP	481	Q9NZW4
SDSYSSRTSSQSKGN	DDX20	656	Q9UHI6
TTSSSATSGSNYQRD	C5orf52	26	A6NGY3
STSDYKDNFGSSSFS	CDK13	1331	Q14004
ESRSAGSSTAYTQSY	ARRDC2	61	Q8TBH0
SYSSSRSDLYSSGRD	RBMX	326	P38159
NSFYGSSSLTNSSQS	PUM2	521	Q8TB72
AKYRSASSTSSLFSS	PUM2	671	Q8TB72
DYRQSSGASSSSFSS	DDX3X	601	O00571
GKNASTSATSRSYSS	EMCN	176	Q9ULC0
SSSSSYTNYADSVKG	IGHV3-11	71	P01762
LSNFSTSDNGSYSSN	NEDD4	151	P46934
SSSLQASTTNDSGYR	MGA	686	Q8IWI9
DSFRSYNSSVGSESS	L3MBTL2	31	Q969R5
SARSYSTESYGASQT	LRRC7	1201	Q96NW7
SSLYSGSAQSSRSNS	BAIAP2L2	301	Q6UXY1
LFSGDFSASTYSNSV	FSIP2	4421	Q5CZC0
ASLFSTYASAEADSS	MYH8	621	P13535
KSSRDSLQYSSGYST	MTSS2	461	Q765P7
SLSPGAFSYSSSSRF	PRPH	26	P41219
AFSYSSSSRFSSSRL	PRPH	31	P41219
SSADLSSLSGFNTAS	MEF2C	326	Q06413
LSSSSGGSSSFDRFA	OR5AN1	261	Q8NGI8
RTSSGDFKFSSSYSA	PPP4R3C	766	Q6ZMV5
STGNSLTFHFYSDSS	CUBN	1936	O60494
SSSTSSQAHYRLSAF	ADAMTS9	91	Q9P2N4
YSDGSSSILSTNNAT	CSF1R	61	P07333
FYSRAASSTSQSGLS	FAM126A	351	Q9BYI3
KQFTSSTSYNRGDST	FGA	581	P02671
STSYNRGDSTFESKS	FGA	586	P02671
TESLYSFDSRRSSGF	DAGLA	786	Q9Y4D2
ASSYSFSDLNSTRGD	EMD	56	P50402
SYQGSGKSLTFSDTS	GRM1	936	Q13255
ANSSFYSTRSAPASQ	NUMA1	1831	Q14980
FSSYRNDSSSSLGSA	MEX3B	281	Q6ZN04
NDSSSSLGSASTDSY	MEX3B	286	Q6ZN04
SAFSSFDFSYSGAER	MEIOC	541	A2RUB1
SADTGQYASTSASSS	SP4	341	Q02446
YPSSRDSYSSSSRGA	RBMXL1	356	Q96E39
SSSTFSFSGRDSSFT	SVIL	226	O95425
FNSRGFEDSYATDSS	SYT16	311	Q17RD7
GDASYTASAIRSSTY	RFX1	301	P22670
RDSAYSSFSASSNAS	SHROOM4	186	Q9ULL8
VASNFTFGASSSSAR	MSH4	96	O15457
SSVNTFRPAYSSFSS	PEX13	66	Q92968
RDAYGTSSLSSSSNS	SNPH	26	O15079
AYSSDRSGTSNSQSQ	PLK4	376	O00444
DSVFSSAATSSNAYT	AGFG1	381	P52594
SLSGTSYSFSSLENT	CNK3/IPCEF1	651	G9CGD6
AGASAASYSSTQFDS	TPRA1	326	Q86W33
ASFGASSLSSLYESS	UBE4B	261	O95155
SSLSGVENLNSSYFS	ZBTB18	246	Q99592
QSRSYSSADSYSSTR	SRRM4	596	A7MD48
ARGSYSSIVNSSSSS	TMEM131	1616	Q92545
SAFSTRSDASGTNDF	PXDN	1371	Q92626
AASTSGSASTSLSYD	PHF19	451	Q5T6S3
ESSSASASSYYSQDD	SUCO	31	Q9UBS9
SGYLSVLASSTFAAS	TSPAN11	46	A1L157
LLYSSSQDGFLSSST	nan	16	Q6ZVL8
VGSYSSAAFNSTRDF	ZIC1	86	Q15915
SPALSYSSAGSARSS	TTC28	2321	Q96AY4
YAAATLQASSAASSA	XRCC1	211	P18887
SLSSSGSYSLQATNE	ZNF474	141	Q6S9Z5
LSSATFSSAFSDNGL	PHLPP1	1531	O60346
GNSNSSSSRLSQYFE	UHRF1BP1	301	Q6BDS2
DDSRSYASSFSGYST	WWC3	66	Q9ULE0
ASNASSYLTSASSLA	UBR5	1771	O95071
FDSSGSFLSYINTSA	TRIM3	696	O75382