Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
DomainLEM/LEM-like_dom

ANKLE1 ANKLE2

1.24e-047462IPR011015
DomainLEM_dom

ANKLE1 ANKLE2

1.24e-047462IPR003887
DomainLEM

ANKLE1 ANKLE2

1.24e-047462PS50954
Domain-

ANKLE1 ANKLE2

1.24e-0474621.10.720.40
DomainLEM

ANKLE1 ANKLE2

1.24e-047462PF03020
DomainGrowth_fac_rcpt_

ELAPOR2 THBD LAMB2

6.67e-03156463IPR009030
PathwayREACTOME_RELEASE_OF_HH_NP_FROM_THE_SECRETING_CELL

NOTUM IHH

9.13e-057302MM15187
PathwayREACTOME_RELEASE_OF_HH_NP_FROM_THE_SECRETING_CELL

NOTUM IHH

1.22e-048302M27444
PathwayREACTOME_PYRIMIDINE_SALVAGE

TK2 TYMP

2.38e-0411302MM15422
PathwayREACTOME_PYRIMIDINE_SALVAGE

TK2 TYMP

2.38e-0411302M27689
PathwayWP_BIOMARKERS_FOR_PYRIMIDINE_METABOLISM_DISORDERS

TK2 TYMP

4.52e-0415302M39841
PathwayWP_PYRIMIDINE_METABOLISM_AND_RELATED_DISEASES

TK2 TYMP

8.12e-0420302M39765
PathwayREACTOME_NUCLEOTIDE_SALVAGE

TK2 TYMP

1.08e-0323302M27831
PathwayREACTOME_NUCLEOTIDE_SALVAGE

TK2 TYMP

1.08e-0323302MM15552
Pubmed

Comparative sequence of human and mouse BAC clones from the mnd2 region of chromosome 2p13.

HTRA2 LOXL3

2.10e-0555129927484
Pubmed

DPYD, TYMS, TYMP, TK1, and TK2 genetic expressions as response markers in locally advanced rectal cancer patients treated with fluoropyrimidine-based chemoradiotherapy.

TK2 TYMP

2.10e-05551224455740
Pubmed

Disruption of a hedgehog-foxf1-rspo2 signaling axis leads to tracheomalacia and a loss of sox9+ tracheal chondrocytes.

NOTUM IHH

2.50e-041651233328171
Pubmed

Aberrant and constitutive expression of FOXL2 impairs ovarian development and functions in mice.

AMH IHH

2.83e-041751232945847
Pubmed

Epithelial hedgehog signals pattern the intestinal crypt-villus axis.

CHGA IHH

3.18e-041851215590741
Pubmed

TRIM28-dependent SUMOylation protects the adult ovary from activation of the testicular pathway.

AMH IHH

4.78e-042251235906245
Pubmed

Endodermal Hedgehog signals modulate Notch pathway activity in the developing digestive tract mesenchyme.

CHGA IHH

4.78e-042251221750033
Pubmed

Comparison of an expanded ataxia interactome with patient medical records reveals a relationship between macular degeneration and ataxia.

LAMB2 CARD10 EIF3A

7.04e-0411851321078624
Pubmed

Transcription factor ATF5 is required for terminal differentiation and survival of olfactory sensory neurons.

CHGA KIRREL2

7.23e-042751223090999
Pubmed

Eliminating SF-1 (NR5A1) sumoylation in vivo results in ectopic hedgehog signaling and disruption of endocrine development.

AMH CHGA

7.78e-042851221820362
Pubmed

Kruppel-like factor 5 controls villus formation and initiation of cytodifferentiation in the embryonic intestinal epithelium.

CHGA IHH

1.36e-033751223266329
Pubmed

The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4.

SLC49A4 HELZ2 ANKLE2 RNF227

1.43e-0333251437433992
GeneFamilyLEM domain containing

ANKLE1 ANKLE2

7.17e-0573421087
ToppCelldroplet-Pancreas-Endocrine-18m-Epithelial-nan|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EPM2A PRSS53 GRIP2 CHGA

3.61e-0516650466026988509e39e41274fa0de738383219e8ff30
ToppCell3'_v3-bone_marrow-Myeloid_Mac-Intermediate_macrophages|bone_marrow / Manually curated celltypes from each tissue

THBD LAMB2 LOXL3 SPOCD1

3.78e-051685048ade4d098aeecda2d80c1cad1cebe9a063eae948
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell_prolif|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

RASAL3 GRIP2 SLC15A3 B3GAT2

3.87e-051695047c994653b0d629dfb046755d6b678452de0a15d2
ToppCellfacs-Pancreas-Exocrine-3m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ELAPOR2 ABHD15 EPM2A PRSS53

4.73e-05178504fcbbcc44271515de1969b4732b6441c012693d5f
ToppCell3'-Broncho-tracheal-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.0.3.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

THBD SLC15A3 TYMP SPOCD1

4.73e-051785040b398656f26c4061b11ccf98908d0e2e1367585a
ToppCellPCW_07-8.5-Neuronal-Neuronal_postreplicative-neuro_migrating_neuronal_(3)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

NOTUM GRIP2 CHGA SLC15A3

4.84e-05179504df6d2cdc4e204ce1a4628dc71dfbc5e6c6309b2a
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d14-21-Myeloid-Dendritic-conventional_dendritic_cell-DC_c2-CD1C|Severe-critical_convalescent_d14-21 / Compartment, severity and other cell annotations on 10x 3' data (130k)

THBD PLB1 SLC15A3 TYMP

4.94e-051805042bc3fd2e4c249bf236340c5f0483747faa5c04ec
ToppCellwk_20-22-Epithelial-PNS-intermediate_Schwann|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

CARD10 GRIP2 KIRREL2 GASK1B

5.38e-051845044e3ba64692868563a579902aa9c6f88cab5bce26
ToppCellfacs-Pancreas-Endocrine-3m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ELAPOR2 ABHD15 PRSS53 CHGA

6.22e-05191504f76f3f5c7902a3659d8cbe470f96ce57c8a6744d
ToppCellfacs-Pancreas-Endocrine-3m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ELAPOR2 ABHD15 PRSS53 CHGA

6.35e-051925045b7093d5af5ae7b0e6d3a464cc56272440ecedad
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Myeloid|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

THBD SLC15A3 TYMP GASK1B

6.48e-051935042ebb950476767f330241b0077ced22e55e124359
ToppCellMesenchymal_cells-Fibro/Chondro_p.|World / Lineage and Cell class

NOTUM LOXL3 PROSER2 IHH

6.88e-05196504ddc168849e0e97005a111be004463bb72d433853
ToppCellTracheal-NucSeq-Stromal-Mesofibroblastic-Mesothelia|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

THBD TK2 RPUSD3 LOXL3

7.01e-05197504e91572edbe48d40269ee2cf7c858764cff6985ac
ToppCell3'_v3-GI_small-bowel-Myeloid_Monocytic|GI_small-bowel / Manually curated celltypes from each tissue

THBD SLC15A3 TYMP GASK1B

7.01e-05197504dcf0009057576a7db9065e644a3919d6de2ac8e6
ToppCellTracheal-NucSeq-Stromal-Mesofibroblastic|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

THBD TK2 RPUSD3 LOXL3

7.01e-051975047e3f78a61089d1200cc6b0fa2034bf2998651694
ToppCell10x5'-Liver-Myeloid_Monocytic-Classical_monocytes|Liver / Manually curated celltypes from each tissue

THBD SLC15A3 TYMP GASK1B

7.29e-0519950446491e8e76aa4d7ada036946f93cf71609c85462
ToppCell10x5'-bone_marrow-Myeloid_Monocytic-Classical_monocytes|bone_marrow / Manually curated celltypes from each tissue

THBD SLC15A3 TYMP GASK1B

7.29e-051995042c747e9265594e12d46bd8c8de75c45e83144155
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW10-Mesenchymal|GW10 / Sample Type, Dataset, Time_group, and Cell type.

THBD RASAL3 HELZ2 GASK1B

7.44e-052005045c638c80661017c85f9390f1b398ac7728c8f001
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW10-Mesenchymal-BMP_responsible_cell|GW10 / Sample Type, Dataset, Time_group, and Cell type.

THBD RASAL3 HELZ2 GASK1B

7.44e-05200504604a88633d4162337e394155c7346dbdef8b9f5a
ToppCellsevere-HLA-DR-_S100A+_Monocyte|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

THBD SLC15A3 TYMP GASK1B

7.44e-05200504a5eb50cbf3e94f0b3aa0fbef888989a11cffea37
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW12-Mesenchymal-Unfolded_protein_responsible_cell|GW12 / Sample Type, Dataset, Time_group, and Cell type.

ABHD15 EPM2A ZNF337 KIRREL2

7.44e-052005046b7314c425f6b40f1301dd39cc02b0436e96a2ec
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW12-Mesenchymal|GW12 / Sample Type, Dataset, Time_group, and Cell type.

ABHD15 EPM2A ZNF337 KIRREL2

7.44e-05200504be83f442179ba4217d12f0458059586ff3130991
Diseaseendometrial cancer (is_marker_for)

HTRA2 TYMP

1.62e-0335502DOID:1380 (is_marker_for)
Diseasehair color

PLB1 NOTUM SLC49A4 ZNF831

1.90e-03311504EFO_0003924
Diseaseend stage renal disease (is_marker_for)

THBD CHGA

2.78e-0346502DOID:783 (is_marker_for)
Diseaseocular hypertension, response to triamcinolone acetonide

RRP7BP RPUSD3

3.15e-0349502EFO_0006954, EFO_1001069

Protein segments in the cluster

PeptideGeneStartEntry
VREVRGLLGRPGWRD

CARD10

951

Q9BWT7
IAVRWLVRRLGPRPG

ANKLE2

26

Q86XL3
APAGEPRLTRWLRRG

CYB561D1

11

Q8N8Q1
AGWPPARRRRLGVHL

ANKLE1

576

Q8NAG6
EQGRVVLWGREGRPG

CXorf49;

71

A8MYA2
WRRPAGHRRKDPGII

CALHM3

81

Q86XJ0
WGGVDIRRGGIPVLR

FBXO10

601

Q9UK96
WAGYRPGPVRRRGKV

BCL2L12

41

Q9HB09
GSRLGPIVRRWAPRP

CCNP

11

Q9H8S5
LGPRLRGPWGRAVGE

ABHD15

21

Q6UXT9
RGPWGRAVGERTLPG

ABHD15

26

Q6UXT9
ARRRQSAGPWPRPKG

RASAL3

826

Q86YV0
WELGGRPLRPGARVR

OBSL1

1751

O75147
RPELGRWEPRGAVRL

EPM2A

26

O95278
IRPAVGWGRRPLPVT

LOXL3

171

P58215
RERGRGQPLPWELRL

LAMB2

6

P55268
VEWRGRDPRGPGRAQ

AMH

436

P03971
ASGPGPRRVQRRAWP

TK2

26

O00142
RGPVRGRGWGRPAEA

ELAPOR2

6

A8MWY0
GRGWGRPAEAPRRGR

ELAPOR2

11

A8MWY0
EGRKTWRRRGQQPPP

NOTUM

21

Q6P988
GERPWRLVRGPGVRA

GASK1B

176

Q6UWH4
GGIRWGRRPRLTPDL

HTRA2

21

O43464
DDGRRKPGIGGRERW

CD99L2

81

Q8TCZ2
PCLRRLWGRGARPEV

DNLZ

21

Q5SXM8
RGPPEKEWRRGEGRD

EIF3A

911

Q14152
DRGPRRGLDDDRGPW

EIF3A

1106

Q14152
RPRDEGGWRRGPAEE

EIF3A

1241

Q14152
VPGPGRVYGRRWLVL

SLC49A4

41

Q96SL1
VWPVGLVGGRRYERP

B3GAT2

206

Q9NPZ5
RGPPGWRRREELRLP

C6orf118

166

Q5T5N4
ATPREGGPRRRWLRE

FRMD6-AS1

316

P0C7T7
RGNPLPRVTWTRRGG

KIRREL2

336

Q6UWL6
VEQGVAQRRRWPPRG

HELZ2

951

Q9BYK8
LEGRPGHRPWQRGRE

GRIP2

906

Q9C0E4
RQPLLPRGARGPRRW

SLC15A3

16

Q8IY34
WGCGPGRVVGSRRRP

IHH

26

Q14623
GWRRGLGVRPVPEDA

RPUSD3

21

Q6P087
VGRRRLWIGLQLPPG

THBD

81

P07204
RPGEWRTPAARGPRS

PROSER2

221

Q86WR7
RWLWPRRAVGPARRP

MTRF1L

11

Q9UGC7
WGRGPIRRGLGPRSS

PRR3

81

P79522
DRVLGPARRWRRPLP

RNF227

156

A6NIN4
VVWRCRRGGRREDPP

PLB1

1436

Q6P1J6
PGPQLRRGWRPSSRE

CHGA

386

P10645
LWGPCPRIRRGIRGG

CLCNKB

21

P51801
GWVKVTRRGRRPVLP

RRP7BP

26

Q9NSQ0
PDGERGWVLGRARPG

PRSS53

411

Q2L4Q9
GRACPWREPIRGRRG

STK19

51

P49842
WREPIRGRRGARPGG

STK19

56

P49842
RDRGPRLLGEPRWGQ

ZNF48

91

Q96MX3
RGISAWQRPPRGRGR

SPOCD1

1081

Q6ZMY3
RPGGSRLRGGTWTPR

PYCARD-AS1

96

I3L0S3
PGRRRAPGPVRSTWT

ZNF831

461

Q5JPB2
LRRGTPWLRVHRDGP

TYMP

431

P19971
SLGRRPRRKWEVFPG

ZDHHC18

61

Q9NUE0
QGEVPWGEERRRRPG

ZNF337

66

Q9Y3M9
WGEERRRRPGPCAGI

ZNF337

71

Q9Y3M9
GLRREPGGPRRWVTV

MZF1

121

P28698