Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	RNA polymerase II cis-regulatory region sequence-specific DNA binding	TCF4 ZNF845 SOX14 ZNF227 ZNF883 ZNF879 ZNF689 CREB3 TET1 ZNF707	3.65e-04	1244	45	10	GO:0000978
GeneOntologyMolecularFunction	cis-regulatory region sequence-specific DNA binding	TCF4 ZNF845 SOX14 ZNF227 ZNF883 ZNF879 ZNF689 CREB3 TET1 ZNF707	4.33e-04	1271	45	10	GO:0000987
HumanPheno	Abnormal large intestine physiology	TCF4 JMJD1C HPS6	2.74e-05	58	6	3	HP:0012700
Domain	TMP21-related	TMED9 TMED4	1.57e-04	8	45	2	IPR015720
Domain	EMP24_GP25L	TMED9 TMED4	2.02e-04	9	45	2	SM01190
Domain	EMP24_GP25L	TMED9 TMED4	5.84e-04	15	45	2	PF01105
Domain	GOLD_dom	TMED9 TMED4	9.46e-04	19	45	2	IPR009038
Domain	GOLD	TMED9 TMED4	9.46e-04	19	45	2	PS50866
Domain	-	ZNF845 ZNF775 ZNF227 ZNF883 ZNF879 ZNF689 ZNF707	1.11e-03	679	45	7	3.30.160.60
Domain	zf-C2H2	ZNF845 ZNF775 ZNF227 ZNF883 ZNF879 ZNF689 ZNF707	1.25e-03	693	45	7	PF00096
Domain	Znf_C2H2/integrase_DNA-bd	ZNF845 ZNF775 ZNF227 ZNF883 ZNF879 ZNF689 ZNF707	1.26e-03	694	45	7	IPR013087
Domain	KRAB	ZNF845 ZNF227 ZNF879 ZNF689 ZNF707	1.64e-03	358	45	5	PS50805
Domain	KRAB	ZNF845 ZNF227 ZNF879 ZNF689 ZNF707	1.64e-03	358	45	5	PF01352
Domain	KRAB	ZNF845 ZNF227 ZNF879 ZNF689 ZNF707	1.87e-03	369	45	5	SM00349
Domain	KRAB	ZNF845 ZNF227 ZNF879 ZNF689 ZNF707	1.89e-03	370	45	5	IPR001909
Domain	ZINC_FINGER_C2H2_2	ZNF845 ZNF775 ZNF227 ZNF883 ZNF879 ZNF689 ZNF707	2.36e-03	775	45	7	PS50157
Domain	ZINC_FINGER_C2H2_1	ZNF845 ZNF775 ZNF227 ZNF883 ZNF879 ZNF689 ZNF707	2.40e-03	777	45	7	PS00028
Domain	Znf_C2H2-like	ZNF845 ZNF775 ZNF227 ZNF883 ZNF879 ZNF689 ZNF707	2.74e-03	796	45	7	IPR015880
Domain	Znf_C2H2	ZNF845 ZNF775 ZNF227 ZNF883 ZNF879 ZNF689 ZNF707	2.92e-03	805	45	7	IPR007087
Domain	ZnF_C2H2	ZNF845 ZNF775 ZNF227 ZNF883 ZNF879 ZNF689 ZNF707	2.98e-03	808	45	7	SM00355
Domain	DNA/RNA_helicase_DEAH_CS	DHX15 TTF2	3.21e-03	35	45	2	IPR002464
Domain	DEAH_ATP_HELICASE	DHX15 TTF2	3.78e-03	38	45	2	PS00690
Pubmed	Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells.	ZNF845 ZNF227 ZNF689 ZNF707	1.06e-04	181	47	4	37372979
Pubmed	HectD1 E3 ligase modifies adenomatous polyposis coli (APC) with polyubiquitin to promote the APC-axin interaction.	TNKS CTTNBP2	1.38e-04	13	47	2	23277359
Pubmed	Identification of candidate genes at the corticoseptal boundary during development.	TCF4 CREB3	1.86e-04	15	47	2	16458080
Pubmed	Zinc-finger genes Fez and Fez-like function in the establishment of diencephalon subdivisions.	TCF4 SOX14	3.34e-04	20	47	2	16971467
Pubmed	NANOG-dependent function of TET1 and TET2 in establishment of pluripotency.	JMJD1C TET1	6.14e-04	27	47	2	23395962
Pubmed	Substrate trapping proteomics reveals targets of the βTrCP2/FBXW11 ubiquitin ligase.	TNKS PTPN13 CTTNBP2	7.01e-04	128	47	3	25332235
Pubmed	Control of developmentally primed erythroid genes by combinatorial co-repressor actions.	TCF4 JMJD1C	7.59e-04	30	47	2	26593974
Pubmed	De novo protein identification in mammalian sperm using in situ cryoelectron tomography and AlphaFold2 docking.	TEKT4 EFCAB6	1.03e-03	35	47	2	37865089
Pubmed	Multiethnic meta-analysis of genome-wide association studies in >100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease.	CD300LF JMJD1C	1.03e-03	35	47	2	23969696
Pubmed	Context-specific function of the LIM homeobox 1 transcription factor in head formation of the mouse embryo.	PCDH11X TCF4	1.03e-03	35	47	2	25977363
Pubmed	The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.	DHX15 TMED9 ZNF845 TNKS ZNF227 JMJD1C ZNF707	1.09e-03	1203	47	7	29180619
Pubmed	In-cell structural insight into the stability of sperm microtubule doublet.	TEKT4 EFCAB6	1.09e-03	36	47	2	37989994
Pubmed	Mouse screen reveals multiple new genes underlying mouse and human hearing loss.	TCF4 CTTNBP2 JMJD1C ZNF879 USP20 MAP3K1 TET1	1.31e-03	1242	47	7	30973865
GeneFamily	Transmembrane p24 trafficking proteins	TMED9 TMED4	1.62e-04	10	35	2	1064
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF845 ZNF775 ZNF227 ZNF883 ZNF879 ZNF689 ZNF707	3.85e-04	718	35	7	28
Disease	social interaction measurement	TCF4 TNKS CTTNBP2	3.52e-04	94	43	3	EFO_0009592
Disease	prothrombin time measurement	TTF2 JMJD1C	4.28e-04	21	43	2	EFO_0008390
Disease	household income	TCF4 CTTNBP2 JMJD1C HPS6	9.93e-04	304	43	4	EFO_0009695
Disease	major depressive disorder	SFTA2 TCF4 CTTNBP2	1.50e-03	155	43	3	MONDO_0002009
Disease	idiopathic osteonecrosis of the femoral head	CTTNBP2 UMODL1	2.63e-03	52	43	2	EFO_1001930

Protein segments in the cluster

Peptide	Gene	Start	Entry
HPSCNVSHSNGTHVL	UMODL1	1021	Q5DID0
QHRTALHLACTSGHV	ANKRD20A1	66	Q5TYW2
RHHSPSQRSHCSPSR	C2orf16	1581	Q68DN1
THAGHAGHTSLPQCI	DHX15	101	O43143
LTSHSSHQECHPEAG	DISP1	91	Q96F81
SSHLVHPSCHGSGAQ	GAB3	231	Q8WWW8
SHIPQSSSYCSLHPH	TCF4	246	P15884
HPFPLHSSSHRTCLN	JMJD1C	736	Q15652
HSSSHRTCLNPGTHH	JMJD1C	741	Q15652
GHPRLESAHASSLSH	JMJD1C	811	Q15652
SSCHRTDPLHRFHTN	FAM199X	51	Q6PEV8
RIAQHLIHCDPSTSH	FAM214A	376	Q32MH5
LCHSPPLSQASTQHH	PCDH11X	1171	Q9BZA7
SEIHAHLHTPGNCSR	GCNT7	76	Q6ZNI0
HTRKFTHSRPHSSPC	EFCAB6	16	Q5THR3
HSLHSPCANTSLHPG	CTTNBP2	426	Q8WZ74
AHHASTQGTSHRPSL	FNDC1	621	Q4ZHG4
VCTGHHTNAHLPLES	FMO5	146	P49326
SSSPTLTGHHLDNRH	CD300LF	136	Q8TDQ1
TVHNTHPRNGHCSSA	FSHR	661	P23945
HTCSHPLSHPTSGQR	CT62	121	P0C5K7
TSLGRTHVLLHHCPA	HPS6	176	Q86YV9
ILSSSNPCLVHHDHT	CREB3	66	O43889
TDLRCHSHRHPSHPT	RTL8C	141	O15255
HHSSSLRSTCPHPQV	DRP2	26	Q13474
RHIHRSGPIITHCSA	PTPN13	2396	Q12923
RPHSQCLNSSPLSHH	MAP3K1	961	Q13233
DALRHTSSCLSSHGH	MIGA1	606	Q8NAN2
SHRPLHRHGSCVETS	TMEM151B	551	Q8IW70
LCLSLEHQGHHSSHP	NHSL2	601	Q5HYW2
CGRHHSQSTEVQAHP	TEKT4	216	Q8WW24
NCSSIPHSSHSIINH	TET1	831	Q8NFU7
SQELTLTCHHRLHTG	ZNF845	281	Q96IR2
TSHTPGEHQICLHSN	TMED9	111	Q9BVK6
SCHSRLLAHQTVHTG	ZNF707	186	Q96C28
GTVNHSHHLASSCPT	TTC24	491	A2A3L6
AAACHTSHHSAGSRP	PLEKHG4B	96	Q96PX9
SHETALHCAVASLHP	TNKS	521	O95271
HQKTHSRPATHSCPE	ZNF775	181	Q96BV0
ICSRHSLTQSHGHHP	RAET1G	241	Q6H3X3
LRSSSRPCSPVHHHE	USP20	386	Q9Y2K6
TFTSHTPGDHQICLH	TMED4	101	Q7Z7H5
HRTTHTGEKPHQCPS	ZNF689	251	Q96CS4
SQCSSLIQHHRIHTG	ZNF879	326	B4DU55
SHNSPLICHRRVHTG	ZNF227	446	Q86WZ6
HLPSGTSVTLHHARS	SFTA2	56	Q6UW10
CHSTSLIRHQRTHTG	ZNF883	191	P0CG24
GQHCSPSHTRLHLTS	C16orf82	6	Q7Z2V1
AFGSLSCPSQHTHTH	SOX14	176	O95416
CHAQHPLGSQHVSLS	SIGLEC11	436	Q96RL6
SHGTLIICPASLIHH	TTF2	641	Q9UNY4