Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	voltage-gated sodium channel activity	SCN11A SCN1A SCN2A SCN3A SCN7A SCN8A	6.36e-09	26	114	6	GO:0005248
GeneOntologyMolecularFunction	sodium channel activity	SCN11A ASIC1 SCN1A SCN2A SCN3A SCN7A SCN8A	1.78e-08	52	114	7	GO:0005272
GeneOntologyMolecularFunction	sodium ion binding	SCN1A SCN2A SCN3A SCN8A	9.65e-07	14	114	4	GO:0031402
GeneOntologyMolecularFunction	sodium ion transmembrane transporter activity	SCN11A ASIC1 SCN1A SCN2A SCN3A SCN7A SCN8A SLC4A9	6.25e-06	171	114	8	GO:0015081
GeneOntologyMolecularFunction	alkali metal ion binding	SCN1A SCN2A SCN3A SCN8A	1.37e-05	26	114	4	GO:0031420
GeneOntologyMolecularFunction	monoatomic cation channel activity	SCN11A ASIC1 GRIN2A SCN1A SCN2A SCN3A SCN7A SCN8A UNC80	1.56e-04	343	114	9	GO:0005261
GeneOntologyMolecularFunction	carnitine O-palmitoyltransferase activity	CPT1A CPT1B	1.92e-04	4	114	2	GO:0004095
GeneOntologyMolecularFunction	monoatomic ion channel activity	GABRP SCN11A ASIC1 GRIN2A SCN1A SCN2A SCN3A SCN7A SCN8A UNC80	3.02e-04	459	114	10	GO:0005216
GeneOntologyMolecularFunction	O-palmitoyltransferase activity	CPT1A CPT1B	3.19e-04	5	114	2	GO:0016416
GeneOntologyMolecularFunction	triglyceride binding	FITM1 FITM2	3.19e-04	5	114	2	GO:0017129
GeneOntologyMolecularFunction	metal ion transmembrane transporter activity	SCN11A ASIC1 GRIN2A SLC30A5 SCN1A SCN2A SCN3A SCN7A SCN8A SLC4A9	3.34e-04	465	114	10	GO:0046873
GeneOntologyMolecularFunction	carnitine O-acyltransferase activity	CPT1A CPT1B	4.77e-04	6	114	2	GO:0016406
GeneOntologyMolecularFunction	coenzyme A diphosphatase activity	FITM1 FITM2	4.77e-04	6	114	2	GO:0010945
GeneOntologyMolecularFunction	oxidoreductase activity, acting on the CH-NH group of donors	NOXRED1 BLVRB PRODH	6.58e-04	30	114	3	GO:0016645
GeneOntologyMolecularFunction	amino acid binding	MAT1A CASR GRIN2A PRODH	8.10e-04	73	114	4	GO:0016597
GeneOntologyMolecularFunction	channel activity	GABRP SCN11A ASIC1 GRIN2A SCN1A SCN2A SCN3A SCN7A SCN8A UNC80	8.56e-04	525	114	10	GO:0015267
GeneOntologyMolecularFunction	passive transmembrane transporter activity	GABRP SCN11A ASIC1 GRIN2A SCN1A SCN2A SCN3A SCN7A SCN8A UNC80	8.69e-04	526	114	10	GO:0022803
GeneOntologyMolecularFunction	monoatomic cation transmembrane transporter activity	SCN11A ASIC1 GRIN2A SLC30A5 SCN1A SCN2A SCN3A SCN7A SCN8A SLC4A9 UNC80	1.47e-03	664	114	11	GO:0008324
GeneOntologyMolecularFunction	monoatomic ion transmembrane transporter activity	GABRP SCN11A ASIC1 GRIN2A SLC30A5 SCN1A SCN2A SCN3A SCN7A SCN8A SLC4A9 UNC80	1.92e-03	793	114	12	GO:0015075
GeneOntologyBiologicalProcess	cardiac muscle cell action potential involved in contraction	SCN11A SCN1A SCN2A SCN3A SCN7A SCN8A	1.02e-06	62	111	6	GO:0086002
GeneOntologyBiologicalProcess	membrane depolarization during action potential	SCN11A SCN1A SCN2A SCN3A SCN8A	1.36e-06	36	111	5	GO:0086010
GeneOntologyBiologicalProcess	cardiac muscle cell action potential	SCN11A SCN1A SCN2A SCN3A SCN7A SCN8A	7.51e-06	87	111	6	GO:0086001
GeneOntologyBiologicalProcess	cardiac muscle cell contraction	SCN11A SCN1A SCN2A SCN3A SCN7A SCN8A	1.10e-05	93	111	6	GO:0086003
GeneOntologyBiologicalProcess	sodium ion transmembrane transport	SCN11A ASIC1 SCN1A SCN2A SCN3A SCN7A SCN8A SLC4A9	1.70e-05	208	111	8	GO:0035725
GeneOntologyBiologicalProcess	neuronal action potential	SCN11A SCN1A SCN2A SCN3A SCN8A	2.26e-05	63	111	5	GO:0019228
GeneOntologyBiologicalProcess	actin-mediated cell contraction	SCN11A SCN1A SCN2A SCN3A SCN7A SCN8A	6.46e-05	127	111	6	GO:0070252
GeneOntologyBiologicalProcess	action potential	SCN11A GRIN2A SCN1A SCN2A SCN3A SCN7A SCN8A	1.09e-04	201	111	7	GO:0001508
GeneOntologyBiologicalProcess	sodium ion transport	SCN11A ASIC1 SCN1A SCN2A SCN3A SCN7A SCN8A SLC4A9	1.22e-04	275	111	8	GO:0006814
GeneOntologyBiologicalProcess	cellular catabolic process	ABCA2 ERCC4 MAT1A CYP4F2 TRIM68 CPT1A CPT1B TRIM23 ULK3 PIK3C2B GCAT SEC16A RAB2B PNPLA7 SMCR8 RAB2A FITM2 PRODH	1.22e-04	1253	111	18	GO:0044248
GeneOntologyBiologicalProcess	detection of stimulus	SCN11A OR9K2 OR11G2 OR1S2 CASR GRIN2A OR1N1 OR51L1 OR4S1 GUCA1B SCN1A OR52E1 OR52M1	1.36e-04	722	111	13	GO:0051606
GeneOntologyBiologicalProcess	carnitine shuttle	CPT1A CPT1B	1.71e-04	4	111	2	GO:0006853
GeneOntologyBiologicalProcess	actin filament-based movement	SCN11A SCN1A SCN2A SCN3A SCN7A SCN8A	1.80e-04	153	111	6	GO:0030048
GeneOntologyBiologicalProcess	sensory perception	SCN11A OR9K2 OR11G2 ASIC1 OR1S2 GRIN2A OR1N1 OR51L1 OR4S1 THRB GUCA1B SCN1A SCN8A OR52E1 ANKRD24 OR52M1	1.97e-04	1072	111	16	GO:0007600
GeneOntologyBiologicalProcess	cardiac muscle contraction	SCN11A SCN1A SCN2A SCN3A SCN7A SCN8A	2.89e-04	167	111	6	GO:0060048
GeneOntologyBiologicalProcess	detection of stimulus involved in sensory perception	SCN11A OR9K2 OR11G2 OR1S2 GRIN2A OR1N1 OR51L1 OR4S1 SCN1A OR52E1 OR52M1	3.04e-04	582	111	11	GO:0050906
GeneOntologyBiologicalProcess	behavior	SCN11A ABCA2 UTS2R ASIC1 SPIRE1 CASR GRIN2A CPT1A LGI4 THRB SCN1A SCN2A SCN3A SCN8A	3.05e-04	891	111	14	GO:0007610
GeneOntologyBiologicalProcess	transmission of nerve impulse	SCN11A SCN1A SCN2A SCN3A SCN8A	3.50e-04	112	111	5	GO:0019226
GeneOntologyBiologicalProcess	detection of mechanical stimulus involved in sensory perception of pain	SCN11A GRIN2A SCN1A	3.60e-04	26	111	3	GO:0050966
GeneOntologyCellularComponent	sodium channel complex	SCN11A SCN1A SCN2A SCN3A SCN7A SCN8A UNC80	1.68e-10	29	114	7	GO:0034706
GeneOntologyCellularComponent	voltage-gated sodium channel complex	SCN11A SCN1A SCN2A SCN3A SCN7A SCN8A	2.71e-10	17	114	6	GO:0001518
GeneOntologyCellularComponent	node of Ranvier	SCN1A SCN2A SCN8A	1.68e-04	20	114	3	GO:0033268
GeneOntologyCellularComponent	transporter complex	GABRP SCN11A ABCA2 GRIN2A ATP8B2 SCN1A SCN2A SCN3A SCN7A SCN8A UNC80	2.11e-04	550	114	11	GO:1990351
GeneOntologyCellularComponent	monoatomic ion channel complex	GABRP SCN11A GRIN2A SCN1A SCN2A SCN3A SCN7A SCN8A UNC80	2.29e-04	378	114	9	GO:0034702
GeneOntologyCellularComponent	Mon1-Ccz1 complex	CCZ1B CCZ1	2.92e-04	5	114	2	GO:0035658
GeneOntologyCellularComponent	guanyl-nucleotide exchange factor complex	CCZ1B CCZ1 SMCR8	2.94e-04	24	114	3	GO:0032045
GeneOntologyCellularComponent	cation channel complex	SCN11A SCN1A SCN2A SCN3A SCN7A SCN8A UNC80	3.08e-04	235	114	7	GO:0034703
GeneOntologyCellularComponent	axon initial segment	SCN1A SCN2A SCN8A	5.20e-04	29	114	3	GO:0043194
GeneOntologyCellularComponent	transmembrane transporter complex	GABRP SCN11A ABCA2 GRIN2A SCN1A SCN2A SCN3A SCN7A SCN8A UNC80	5.87e-04	523	114	10	GO:1902495
HumanPheno	Focal impaired awareness seizure	CASR GRIN2A LGI4 SCN1A SCN2A SCN3A SCN8A	1.48e-05	126	34	7	HP:0002384
HumanPheno	Focal hemiclonic seizure	GRIN2A SCN1A SCN2A SCN8A	1.90e-05	25	34	4	HP:0006813
HumanPheno	Simple febrile seizure	SCN1A SCN2A SCN3A SCN8A	2.61e-05	27	34	4	HP:0011171
HumanPheno	Generalized tonic seizure	GRIN2A CTCF SCN1A SCN2A SCN8A	5.61e-05	64	34	5	HP:0010818
HumanPheno	Focal automatism seizure	SCN1A SCN2A SCN8A	5.74e-05	12	34	3	HP:0032898
HumanPheno	Generalized clonic seizure	GRIN2A SCN1A SCN2A SCN8A	6.66e-05	34	34	4	HP:0011169
HumanPheno	Complex febrile seizure	SCN1A SCN2A SCN8A	1.43e-04	16	34	3	HP:0011172
HumanPheno	Focal clonic seizure	GRIN2A SCN1A SCN2A SCN8A	1.55e-04	42	34	4	HP:0002266
HumanPheno	Clonic seizure	GRIN2A SCN1A SCN2A SCN3A SCN8A	1.74e-04	81	34	5	HP:0020221
HumanPheno	Non-convulsive status epilepticus without coma	GRIN2A SCN1A SCN2A	2.87e-04	20	34	3	HP:0032671
HumanPheno	Intellectual disability, progressive	ERCC2 ERCC4 SCN1A SCN8A ATIC UNC80	3.22e-04	144	34	6	HP:0006887
HumanPheno	Infection-related seizure	CASR GRIN2A SCN1A SCN2A SCN3A SCN8A	3.34e-04	145	34	6	HP:0032892
HumanPheno	Seizure precipitated by febrile infection	CASR GRIN2A SCN1A SCN2A SCN3A SCN8A	3.34e-04	145	34	6	HP:0032894
HumanPheno	Febrile seizure (within the age range of 3 months to 6 years)	CASR GRIN2A SCN1A SCN2A SCN3A SCN8A	3.34e-04	145	34	6	HP:0002373
HumanPheno	Bilateral tonic-clonic seizure with focal onset	GRIN2A SCN1A SCN2A SCN8A	3.57e-04	52	34	4	HP:0007334
HumanPheno	Bilateral tonic-clonic seizure with generalized onset	GRIN2A CTCF SCN1A SCN2A	3.57e-04	52	34	4	HP:0025190
HumanPheno	Abnormal peripheral nervous system morphology	SCN11A ERCC2 ERCC4 GBF1 SGCB MAT1A CASR GRIN2A XRCC2 CPT1A LGI4 TERT LYST PPP2R2B SCN1A SCN3A SCN8A CPLANE1 UNC80	4.12e-04	1395	34	19	HP:0000759
HumanPheno	Neonatal electro-clinical non-motor seizure	SCN2A SCN8A	4.27e-04	5	34	2	HP:0032812
HumanPheno	Neonatal seizure with electrographic correlate	SCN2A SCN8A	4.27e-04	5	34	2	HP:0032808
HumanPheno	Neonatal electro-clinical seizure	SCN2A SCN8A	4.27e-04	5	34	2	HP:0032809
HumanPheno	Neonatal electro-clinical seizure with behavior arrest	SCN2A SCN8A	4.27e-04	5	34	2	HP:0032823
HumanPheno	Focal head nodding automatism seizure	SCN2A SCN8A	4.27e-04	5	34	2	HP:0032906
HumanPheno	Squamous cell carcinoma of the skin	ERCC2 ERCC4 TERT	4.39e-04	23	34	3	HP:0006739
Domain	Na_channel_asu	SCN11A SCN1A SCN2A SCN3A SCN7A SCN8A	8.83e-12	10	113	6	IPR001696
Domain	Na_trans_assoc	SCN11A SCN1A SCN2A SCN3A SCN7A SCN8A	8.83e-12	10	113	6	IPR010526
Domain	Na_trans_assoc	SCN11A SCN1A SCN2A SCN3A SCN7A SCN8A	8.83e-12	10	113	6	PF06512
Domain	Na_trans_cytopl	SCN1A SCN2A SCN3A SCN8A	1.89e-08	6	113	4	PF11933
Domain	Na_trans_cytopl	SCN1A SCN2A SCN3A SCN8A	1.89e-08	6	113	4	IPR024583
Domain	Channel_four-helix_dom	SCN11A SCN1A SCN2A SCN3A SCN7A SCN8A	1.21e-06	57	113	6	IPR027359
Domain	-	SCN11A SCN1A SCN2A SCN3A SCN7A SCN8A	1.21e-06	57	113	6	1.20.120.350
Domain	DUF1712	CCZ1B CCZ1	3.63e-05	2	113	2	PF08217
Domain	FIT	FITM1 FITM2	3.63e-05	2	113	2	IPR019388
Domain	Scs3p	FITM1 FITM2	3.63e-05	2	113	2	PF10261
Domain	DUF1712_fun	CCZ1B CCZ1	3.63e-05	2	113	2	IPR013176
Domain	Ion_trans_dom	SCN11A SCN1A SCN2A SCN3A SCN7A SCN8A	6.73e-05	114	113	6	IPR005821
Domain	Ion_trans	SCN11A SCN1A SCN2A SCN3A SCN7A SCN8A	6.73e-05	114	113	6	PF00520
Domain	CPT_N	CPT1A CPT1B	1.08e-04	3	113	2	IPR032476
Domain	CPT_N	CPT1A CPT1B	1.08e-04	3	113	2	PF16484
Domain	IQ	SCN1A SCN2A SCN3A SCN7A SCN8A	1.32e-04	81	113	5	SM00015
Domain	PP2A_PR55	PPP2R2D PPP2R2B	2.16e-04	4	113	2	IPR000009
Domain	PP2A_PR55_CS	PPP2R2D PPP2R2B	2.16e-04	4	113	2	IPR018067
Domain	PR55_2	PPP2R2D PPP2R2B	2.16e-04	4	113	2	PS01025
Domain	PR55_1	PPP2R2D PPP2R2B	2.16e-04	4	113	2	PS01024
Domain	IQ_motif_EF-hand-BS	SCN1A SCN2A SCN3A SCN7A SCN8A	2.16e-04	90	113	5	IPR000048
Domain	EF-hand-dom_pair	CIB4 CAPN13 EFHC2 GUCA1B SCN1A SCN3A SCN7A SCN8A	3.58e-04	287	113	8	IPR011992
Domain	Carn_acyltransf	CPT1A CPT1B	7.47e-04	7	113	2	PF00755
Domain	ACYLTRANSF_C_1	CPT1A CPT1B	7.47e-04	7	113	2	PS00439
Domain	Carn_acyl_trans	CPT1A CPT1B	7.47e-04	7	113	2	IPR000542
Domain	ACYLTRANSF_C_2	CPT1A CPT1B	7.47e-04	7	113	2	PS00440
Domain	DNA/RNA_helicase_DEAH_CS	ERCC2 DHX57 DHX33	1.23e-03	35	113	3	IPR002464
Domain	DEAH_ATP_HELICASE	ERCC2 DHX57 DHX33	1.56e-03	38	113	3	PS00690
Domain	IQ	SCN1A SCN2A SCN3A SCN8A	2.45e-03	93	113	4	PS50096
Domain	-	CNBD2 CNNM1 PNPLA7	3.06e-03	48	113	3	2.60.120.10
Domain	RmlC-like_jellyroll	CNBD2 CNNM1 PNPLA7	3.64e-03	51	113	3	IPR014710
Domain	-	PPP2R2D BIRC6 LYST PPP2R2B WDR90 DMWD WDR72	4.14e-03	333	113	7	2.130.10.10
Domain	WD40/YVTN_repeat-like_dom	PPP2R2D BIRC6 LYST PPP2R2B WDR90 DMWD WDR72	4.28e-03	335	113	7	IPR015943
Domain	DUF1605	DHX57 DHX33	4.65e-03	17	113	2	IPR011709
Domain	OB_NTP_bind	DHX57 DHX33	4.65e-03	17	113	2	PF07717
Domain	WD40	PPP2R2D LYST PPP2R2B WDR90 DMWD WDR72	4.93e-03	259	113	6	PF00400
Domain	HA2	DHX57 DHX33	5.21e-03	18	113	2	SM00847
Domain	HA2	DHX57 DHX33	5.21e-03	18	113	2	PF04408
Domain	Helicase-assoc_dom	DHX57 DHX33	5.21e-03	18	113	2	IPR007502
Domain	WD40	PPP2R2D LYST PPP2R2B WDR90 DMWD WDR72	5.81e-03	268	113	6	SM00320
Domain	WD40_repeat	PPP2R2D LYST PPP2R2B WDR90 DMWD WDR72	6.23e-03	272	113	6	IPR001680
Pathway	REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS	SCN11A SCN1A SCN2A SCN3A SCN7A SCN8A	2.62e-08	31	85	6	M877
Pathway	REACTOME_PHASE_0_RAPID_DEPOLARISATION	SCN11A SCN1A SCN2A SCN3A SCN7A SCN8A	3.21e-08	32	85	6	M27455
Pathway	REACTOME_L1CAM_INTERACTIONS	SCN11A ITGA2B SCN1A SCN2A SCN3A SCN7A SCN8A	8.18e-06	121	85	7	M872
Pathway	WP_DRAVET_SYNDROME	SCN1A SCN2A SCN3A SCN8A	2.26e-05	28	85	4	M45519
Pathway	WP_ADHD_AND_AUTISM_ASD_PATHWAYS	SCN11A MAT1A GRIN2A GCAT SCN1A SCN2A SCN3A SCN7A SCN8A ATIC	6.98e-05	367	85	10	M48346
Pathway	REACTOME_CARDIAC_CONDUCTION	SCN11A SCN1A SCN2A SCN3A SCN7A SCN8A	1.32e-04	130	85	6	M27454
Pathway	WP_RETT_SYNDROME	GRIN2A SCN1A SCN2A SCN8A	1.96e-04	48	85	4	M39759
Pathway	REACTOME_LIPID_PARTICLE_ORGANIZATION	FITM1 FITM2	5.31e-04	6	85	2	M27852
Pathway	REACTOME_LIPID_PARTICLE_ORGANIZATION	FITM1 FITM2	5.31e-04	6	85	2	MM15571
Pubmed	International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels.	SCN11A SCN1A SCN2A SCN3A SCN8A	4.32e-11	9	114	5	16382098
Pubmed	Nav1.1 localizes to axons of parvalbumin-positive inhibitory interneurons: a circuit basis for epileptic seizures in mice carrying an Scn1a gene mutation.	SCN1A SCN2A SCN3A SCN8A	1.09e-10	4	114	4	17537961
Pubmed	Sodium channel expression and transcript variation in the developing brain of human, Rhesus monkey, and mouse.	SCN1A SCN2A SCN3A SCN8A	1.09e-10	4	114	4	35031483
Pubmed	Abnormal changes in voltage-gated sodium channels subtypes NaV1.1, NaV1.2, NaV1.3, NaV1.6 and CaM/CaMKII pathway in low-grade astrocytoma.	SCN1A SCN2A SCN3A SCN8A	1.09e-10	4	114	4	29578003
Pubmed	A 'toothache tree' alkylamide inhibits Aδ mechanonociceptors to alleviate mechanical pain.	SCN1A SCN2A SCN3A SCN8A	1.63e-09	6	114	4	23652591
Pubmed	Expression pattern of neuronal and skeletal muscle voltage-gated Na+ channels in the developing mouse heart.	SCN1A SCN2A SCN3A SCN8A	1.36e-08	9	114	4	15746173
Pubmed	SCN1A, SCN2A and SCN3A gene polymorphisms and responsiveness to antiepileptic drugs: a multicenter cohort study and meta-analysis.	SCN1A SCN2A SCN3A	3.43e-08	3	114	3	23859570
Pubmed	Sodium channels SCN1A, SCN2A and SCN3A in familial autism.	SCN1A SCN2A SCN3A	3.43e-08	3	114	3	12610651
Pubmed	Multidrug resistance in epilepsy and polymorphisms in the voltage-gated sodium channel genes SCN1A, SCN2A, and SCN3A: correlation among phenotype, genotype, and mRNA expression.	SCN1A SCN2A SCN3A	3.43e-08	3	114	3	18784617
Pubmed	Characterization of 5' untranslated regions of the voltage-gated sodium channels SCN1A, SCN2A, and SCN3A and identification of cis-conserved noncoding sequences.	SCN1A SCN2A SCN3A	3.43e-08	3	114	3	17544618
Pubmed	Variable patterns of mutation density among NaV1.1, NaV1.2 and NaV1.6 point to channel-specific functional differences associated with childhood epilepsy.	SCN1A SCN2A SCN8A	3.43e-08	3	114	3	32845893
Pubmed	Comparison and optimization of in silico algorithms for predicting the pathogenicity of sodium channel variants in epilepsy.	SCN1A SCN2A SCN8A	3.43e-08	3	114	3	28518218
Pubmed	Reduced sodium current in Purkinje neurons from Nav1.1 mutant mice: implications for ataxia in severe myoclonic epilepsy in infancy.	SCN1A SCN2A SCN8A	3.43e-08	3	114	3	17928448
Pubmed	Early expression of sodium channel transcripts and sodium current by cajal-retzius cells in the preplate of the embryonic mouse neocortex.	SCN1A SCN2A SCN3A	3.43e-08	3	114	3	14973256
Pubmed	Nav1.2 haplodeficiency in excitatory neurons causes absence-like seizures in mice.	SCN1A SCN2A SCN3A SCN8A	5.31e-08	12	114	4	30175250
Pubmed	Regulation of neuronal voltage-gated sodium channels by the ubiquitin-protein ligases Nedd4 and Nedd4-2.	SCN1A SCN2A SCN3A SCN8A	7.65e-08	13	114	4	15123669
Pubmed	Association of sodium voltage-gated channel genes polymorphisms with epilepsy risk and prognosis in the Saudi population.	SCN1A SCN2A SCN3A	1.37e-07	4	114	3	35801810
Pubmed	Neuronal voltage-gated ion channels are genetic modifiers of generalized epilepsy with febrile seizures plus.	SCN1A SCN2A SCN8A	1.37e-07	4	114	3	21156207
Pubmed	Use of recombinant inbred strains for studying genetic determinants of responses to alcohol.	SCN1A SCN2A SCN3A	1.37e-07	4	114	3	8974318
Pubmed	Confirmation of quantitative trait loci for alcohol preference in mice.	SCN1A SCN2A SCN3A SCN7A	1.45e-07	15	114	4	9726281
Pubmed	Three brain sodium channel alpha-subunit genes are clustered on the proximal segment of mouse chromosome 2.	SCN1A SCN2A SCN3A	3.41e-07	5	114	3	1679748
Pubmed	A new sodium channel alpha-subunit gene (Scn9a) from Schwann cells maps to the Scn1a, Scn2a, Scn3a cluster of mouse chromosome 2.	SCN1A SCN2A SCN3A	3.41e-07	5	114	3	8812438
Pubmed	Early development of electrical excitability in the mouse enteric nervous system.	SCN11A SCN3A SCN8A	3.41e-07	5	114	3	22875929
Pubmed	Small CTD phosphatases function in silencing neuronal gene expression.	CTDSP1 GRIN2A SCN2A	3.41e-07	5	114	3	15681389
Pubmed	Case-control association study of polymorphisms in the voltage-gated sodium channel genes SCN1A, SCN2A, SCN3A, SCN1B, and SCN2B and epilepsy.	SCN1A SCN2A SCN3A	3.41e-07	5	114	3	24337656
Pubmed	Structure/function characterization of micro-conotoxin KIIIA, an analgesic, nearly irreversible blocker of mammalian neuronal sodium channels.	SCN2A SCN3A SCN8A	3.41e-07	5	114	3	17724025
Pubmed	Are voltage-dependent ion channels involved in the endothelial cell control of vasomotor tone?	SCN11A SCN2A SCN8A	6.81e-07	6	114	3	17513486
Pubmed	An animal model of oxaliplatin-induced cold allodynia reveals a crucial role for Nav1.6 in peripheral pain pathways.	SCN11A SCN3A SCN8A	6.81e-07	6	114	3	23711479
Pubmed	Polymorphisms/haplotypes in DNA repair genes and smoking: a bladder cancer case-control study.	ERCC2 ERCC4 XRCC2	6.81e-07	6	114	3	16284380
Pubmed	DNA repair gene variants associated with benign breast disease in high cancer risk women.	ERCC2 ERCC4 XRCC2	1.19e-06	7	114	3	19124519
Pubmed	Diagnostic yield of genetic testing in epileptic encephalopathy in childhood.	SCN1A SCN2A SCN8A	1.19e-06	7	114	3	25818041
Pubmed	Polymorphism in nucleotide excision repair gene XPC correlates with bleomycin-induced chromosomal aberrations.	ERCC2 ERCC4 XRCC2	5.55e-06	11	114	3	17685459
Pubmed	International Lung Cancer Consortium: pooled analysis of sequence variants in DNA repair and cell cycle pathways.	ERCC2 ERCC4 XRCC2	7.38e-06	12	114	3	18990748
Pubmed	Quantitative trait loci mapping of genes that influence the sensitivity and tolerance to ethanol-induced hypothermia in BXD recombinant inbred mice.	SCN1A SCN2A SCN3A	7.38e-06	12	114	3	8169823
Pubmed	Molecular cloning and characterization of a novel human Rab ( Rab2B) gene.	RAB2B RAB2A	1.07e-05	2	114	2	12376746
Pubmed	Variants within the muscle and liver isoforms of the carnitine palmitoyltransferase I (CPT1) gene interact with fat intake to modulate indices of obesity in French-Canadians.	CPT1A CPT1B	1.07e-05	2	114	2	17089095
Pubmed	Array-CGH detection of a de novo 2.8 Mb deletion in 2q24.2-->q24.3 in a girl with autistic features and developmental delay.	SCN2A SCN3A	1.07e-05	2	114	2	20346423
Pubmed	Reduction of Kcnt1 is therapeutic in mouse models of SCN1A and SCN8A epilepsy.	SCN1A SCN8A	1.07e-05	2	114	2	37901435
Pubmed	An Scn1a epilepsy mutation in Scn8a alters seizure susceptibility and behavior.	SCN1A SCN8A	1.07e-05	2	114	2	26410685
Pubmed	Neuronal death and perinatal lethality in voltage-gated sodium channel alpha(II)-deficient mice.	SCN1A SCN2A	1.07e-05	2	114	2	10827969
Pubmed	Differential role of sodium channels SCN1A and SCN2A gene polymorphisms with epilepsy and multiple drug resistance in the north Indian population.	SCN1A SCN2A	1.07e-05	2	114	2	19694741
Pubmed	Commonalities and distinctions between two neurodevelopmental disorder subtypes associated with SCN2A and SCN8A variants and literature review.	SCN2A SCN8A	1.07e-05	2	114	2	35348308
Pubmed	Genomic structures of SCN2A and SCN3A - candidate genes for deafness at the DFNA16 locus.	SCN2A SCN3A	1.07e-05	2	114	2	11245985
Pubmed	Electrophysiological properties of two axonal sodium channels, Nav1.2 and Nav1.6, expressed in mouse spinal sensory neurones.	SCN2A SCN8A	1.07e-05	2	114	2	15760941
Pubmed	Differential expression of two sodium channel subtypes in human brain.	SCN1A SCN2A	1.07e-05	2	114	2	1317301
Pubmed	Duplication of the sodium channel gene cluster on 2q24 in children with early onset epilepsy.	SCN2A SCN3A	1.07e-05	2	114	2	23016767
Pubmed	Whole gene duplication of SCN2A and SCN3A is associated with neonatal seizures and a normal intellectual development.	SCN2A SCN3A	1.07e-05	2	114	2	27153334
Pubmed	Electrophysiological Differences between the Same Pore Region Mutation in SCN1A and SCN3A.	SCN1A SCN3A	1.07e-05	2	114	2	24990319
Pubmed	Clinical exome sequencing identifies two novel mutations of the SCN1A and SCN2A genes in Moroccan patients with epilepsy: a case series.	SCN1A SCN2A	1.07e-05	2	114	2	31439038
Pubmed	Genetic screen in Drosophila muscle identifies autophagy-mediated T-tubule remodeling and a Rab2 role in autophagy.	RAB2B RAB2A	1.07e-05	2	114	2	28063257
Pubmed	Scn8a Antisense Oligonucleotide Is Protective in Mouse Models of SCN8A Encephalopathy and Dravet Syndrome.	SCN1A SCN8A	1.07e-05	2	114	2	31943325
Pubmed	Severe epilepsy, retardation, and dysmorphic features with a 2q deletion including SCN1A and SCN2A.	SCN1A SCN2A	1.07e-05	2	114	2	15249644
Pubmed	Mapping of a FEB3 homologous febrile seizure locus on mouse chromosome 2 containing candidate genes Scn1a and Scn3a.	SCN1A SCN3A	1.07e-05	2	114	2	27690330
Pubmed	Obesity and genetic polymorphism of ERCC2 and ERCC4 as modifiers of risk of breast cancer.	ERCC2 ERCC4	1.07e-05	2	114	2	15886521
Pubmed	The link of ERCC2 rs13181 and ERCC4 rs2276466 polymorphisms with breast cancer in the Bangladeshi population.	ERCC2 ERCC4	1.07e-05	2	114	2	34837148
Pubmed	Reduced expression of Na(v)1.6 sodium channels and compensation by Na(v)1.2 channels in mice heterozygous for a null mutation in Scn8a.	SCN2A SCN8A	1.07e-05	2	114	2	18601978
Pubmed	Correlations in timing of sodium channel expression, epilepsy, and sudden death in Dravet syndrome.	SCN1A SCN3A	1.07e-05	2	114	2	23965409
Pubmed	FGF14 N-terminal splice variants differentially modulate Nav1.2 and Nav1.6-encoded sodium channels.	SCN2A SCN8A	1.07e-05	2	114	2	19465131
Pubmed	Fine chromosome mapping of the genes for human liver and muscle carnitine palmitoyltransferase I (CPT1A and CPT1B).	CPT1A CPT1B	1.07e-05	2	114	2	9070950
Pubmed	SCN1A and SCN2A polymorphisms are associated with response to valproic acid in Chinese epilepsy patients.	SCN1A SCN2A	1.07e-05	2	114	2	30693367
Pubmed	Block of a subset of sodium channels exacerbates experimental autoimmune encephalomyelitis.	SCN2A SCN8A	1.07e-05	2	114	2	23735284
Pubmed	ERCC2 Lys751Gln rs13181 and XRCC2 Arg188His rs3218536 Gene Polymorphisms Contribute to Subsceptibility of Colon, Gastric, HCC, Lung And Prostate Cancer.	ERCC2 XRCC2	1.07e-05	2	114	2	32277685
Pubmed	Association between SCN1A and SCN2A mutations and clinical/EEG features in Chinese patients from epilepsy or severe seizures.	SCN1A SCN2A	1.07e-05	2	114	2	29649454
Pubmed	Contribution of XPD and XPF Polymorphisms to Susceptibility of Non-Small Cell Lung Cancer in High-Altitude Areas.	ERCC2 ERCC4	1.07e-05	2	114	2	33827099
Pubmed	CTCF mediates the TERT enhancer-promoter interactions in lung cancer cells: identification of a novel enhancer region involved in the regulation of TERT gene.	TERT CTCF	1.07e-05	2	114	2	24174344
Pubmed	Structural insights into triglyceride storage mediated by fat storage-inducing transmembrane (FIT) protein 2.	FITM1 FITM2	1.07e-05	2	114	2	20520733
Pubmed	Mice lacking fat storage-inducing transmembrane protein 2 show improved profiles upon pressure overload-induced heart failure.	FITM1 FITM2	1.07e-05	2	114	2	30923760
Pubmed	Effects of SCN1A and SCN2A polymorphisms on responsiveness to valproic acid monotherapy in epileptic children.	SCN1A SCN2A	1.07e-05	2	114	2	33096315
Pubmed	Direct binding of triglyceride to fat storage-inducing transmembrane proteins 1 and 2 is important for lipid droplet formation.	FITM1 FITM2	1.07e-05	2	114	2	22106267
Pubmed	Sodium channel expression within chronic multiple sclerosis plaques.	SCN2A SCN8A	1.07e-05	2	114	2	17805013
Pubmed	Nomenclature of voltage-gated sodium channels.	SCN11A SCN7A	1.07e-05	2	114	2	11144347
Pubmed	Expression and regulation of carnitine palmitoyltransferase-Ialpha and -Ibeta genes.	CPT1A CPT1B	1.07e-05	2	114	2	10408760
Pubmed	Missense mutations in sodium channel SCN1A and SCN2A predispose children to encephalopathy with severe febrile seizures.	SCN1A SCN2A	1.07e-05	2	114	2	26311622
Pubmed	Aberrant regulation of a poison exon caused by a non-coding variant in a mouse model of Scn1a-associated epileptic encephalopathy.	SCN1A SCN8A	1.07e-05	2	114	2	33411788
Pubmed	An element in the region responsible for premature termination of transcription mediates repression of c-myc gene expression by thyroid hormone in neuroblastoma cells.	THRB CTCF	1.07e-05	2	114	2	10625678
Pubmed	Associations between XRCC2 rs3218536 and ERCC2 rs13181 polymorphisms and ovarian cancer.	ERCC2 XRCC2	1.07e-05	2	114	2	27863412
Pubmed	The DNA repair gene XPD/ERCC2 polymorphisms Arg156Arg (exon 6) and Lys751Gln (exon 23) are closely associated.	ERCC2 XRCC2	1.07e-05	2	114	2	17604576
Pubmed	Calcium-sensing receptor bridges calcium and telomerase reverse transcriptase in gastric cancers via Akt.	CASR TERT	1.07e-05	2	114	2	31650467
Pubmed	Genetic variation in XPD predicts treatment outcome and risk of acute myeloid leukemia following chemotherapy.	ERCC2 XRCC2	1.07e-05	2	114	2	15339847
Pubmed	Evolutionarily conserved gene family important for fat storage.	FITM1 FITM2	1.07e-05	2	114	2	18160536
Pubmed	The developmental changes of Na(v)1.1 and Na(v)1.2 expression in the human hippocampus and temporal lobe.	SCN1A SCN2A	1.07e-05	2	114	2	21377452
Pubmed	LINE-1 (L1) lineages in the mouse.	LYST SCN8A	1.07e-05	2	114	2	10742052
Pubmed	Direct amplification of a single dissected chromosomal segment by polymerase chain reaction: a human brain sodium channel gene is on chromosome 2q22-q23.	SCN2A SCN7A	1.07e-05	2	114	2	1846440
Pubmed	Persistent Nav1.1 and Nav1.6 currents drive spinal locomotor functions through nonlinear dynamics.	SCN1A SCN8A	1.07e-05	2	114	2	37665666
Pubmed	The voltage-gated sodium channel Scn8a is a genetic modifier of severe myoclonic epilepsy of infancy.	SCN1A SCN8A	1.07e-05	2	114	2	17881658
Pubmed	Polymorphisms in the DNA repair genes XPD (ERCC2) and XPF (ERCC4) are not associated with sporadic late-onset Alzheimer's disease.	ERCC2 ERCC4	1.07e-05	2	114	2	16806697
Pubmed	Inhibition of carnitine palmitoyltransferase I augments sphingolipid synthesis and palmitate-induced apoptosis.	CPT1A CPT1B	1.07e-05	2	114	2	9013572
Pubmed	Polymorphisms in genes of nucleotide and base excision repair: risk and prognosis of colorectal cancer.	ERCC2 ERCC4 XRCC2	1.52e-05	15	114	3	16609022
Pubmed	Influence of polymorphisms in xenobiotic-metabolizing genes and DNA-repair genes on diepoxybutane-induced SCE frequency.	ERCC2 ERCC4 XRCC2	2.26e-05	17	114	3	17078101
Pubmed	Voltage-gated sodium channels in taste bud cells.	SCN2A SCN3A	3.19e-05	3	114	2	19284629
Pubmed	Association of SCN1A, SCN2A, and UGT2B7 Polymorphisms with Responsiveness to Valproic Acid in the Treatment of Epilepsy.	SCN1A SCN2A	3.19e-05	3	114	2	32185219
Pubmed	Clinical exome sequencing as the first-tier test for diagnosing developmental disorders covering both CNV and SNV: a Chinese cohort.	SCN1A SCN2A	3.19e-05	3	114	2	32005694
Pubmed	Mutations in the sodium channel genes SCN1A, SCN3A, and SCN9A in children with epilepsy with febrile seizures plus(EFS+).	SCN1A SCN3A	3.19e-05	3	114	2	33895391
Pubmed	PI3KC3 complex subunit NRBF2 is required for apoptotic cell clearance to restrict intestinal inflammation.	CCZ1B CCZ1	3.19e-05	3	114	2	32160108
Pubmed	Genomic structure of and a cardiac promoter for the mouse carnitine palmitoyltransferase II gene.	CPT1A CPT1B	3.19e-05	3	114	2	8307575
Pubmed	Where is the spike generator of the cochlear nerve? Voltage-gated sodium channels in the mouse cochlea.	SCN2A SCN8A	3.19e-05	3	114	2	16033895
Pubmed	GAPDH-mediated posttranscriptional regulations of sodium channel Scn1a and Scn3a genes under seizure and ketogenic diet conditions.	SCN1A SCN3A	3.19e-05	3	114	2	27816501
Pubmed	Polymorphisms in DNA repair genes in gastrointestinal stromal tumours: susceptibility and correlation with tumour characteristics and clinical outcome.	ERCC2 ERCC4	3.19e-05	3	114	2	27460091
Pubmed	Inter-individual variation in nucleotide excision repair in young adults: effects of age, adiposity, micronutrient supplementation and genotype.	ERCC2 ERCC4	3.19e-05	3	114	2	18838045
Pubmed	Experimental and computational evidence that Calpain-10 binds to the carboxy terminus of NaV1.2 and NaV1.6.	SCN2A SCN8A	3.19e-05	3	114	2	38514708
Interaction	SCN4B interactions	SCN1A SCN2A SCN8A	7.99e-06	8	107	3	int:SCN4B
Cytoband	Ensembl 112 genes in cytogenetic band chr2q24	SCN1A SCN2A SCN3A SCN7A	2.95e-04	127	114	4	chr2q24
Cytoband	2q24.3	SCN1A SCN2A	7.17e-04	16	114	2	2q24.3
Cytoband	2q35	CTDSP1 ATIC UNC80	1.03e-03	79	114	3	2q35
Cytoband	Ensembl 112 genes in cytogenetic band chr9q34	ABCA2 TOR2A SEC16A PNPLA7 QSOX2	1.35e-03	325	114	5	chr9q34
Cytoband	11p15.4	TRIM68 OR51L1 OR52E1 OR52M1	1.61e-03	200	114	4	11p15.4
Cytoband	9q34.3	SEC16A PNPLA7 QSOX2	2.39e-03	106	114	3	9q34.3
Cytoband	Ensembl 112 genes in cytogenetic band chr11p15	BRSK2 TRIM68 ZBED5 OR51L1 OR52E1 OR52M1	2.92e-03	564	114	6	chr11p15
GeneFamily	Sodium voltage-gated channel alpha subunits	SCN11A SCN1A SCN2A SCN3A SCN8A	1.33e-10	9	75	5	1203
GeneFamily	WD repeat domain containing\|ERCC excision repair associated	ERCC2 ERCC4	3.52e-04	7	75	2	1268
GeneFamily	WD repeat domain containing\|Xeroderma pigmentosum complementation groups\|Nucleotide excision repair	ERCC2 ERCC4	4.68e-04	8	75	2	1125
GeneFamily	WD repeat domain containing	PPP2R2D LYST PPP2R2B WDR90 DMWD WDR72	7.63e-04	262	75	6	362
GeneFamily	WD repeat domain containing\|Protein phosphatase 2 regulatory subunits	PPP2R2D PPP2R2B	1.72e-03	15	75	2	696
GeneFamily	DEAH-box helicases	DHX57 DHX33	1.96e-03	16	75	2	500
GeneFamily	Ring finger proteins\|Fanconi anemia complementation groups\|Protein phosphatase 1 regulatory subunits\|BRCA1 A complex\|BRCA1 B complex\|BRCA1 C complex	ERCC4 XRCC2	3.07e-03	20	75	2	548
ToppCell	Parenchymal-NucSeq-Epithelial-Epi_airway_neuro-secretory-Neuroendocrine\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	TCERG1L BRSK2 CASR RFX6 SCN2A SCN3A SCN8A UNC80	4.21e-08	198	113	8	8f25e8dff42bad8e779ca618bdb1cb1610667962
ToppCell	Parenchymal-NucSeq-Epithelial-Epi_airway_neuro-secretory\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	TCERG1L BRSK2 CASR RFX6 SCN2A SCN3A SCN8A UNC80	4.21e-08	198	113	8	e3e0aa3ef20b2370f5b133048510677aaa562dfa
ToppCell	Fetal_29-31_weeks-Epithelial-lung_neuroendocrine_cell_(PNEC)\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	TCERG1L BRSK2 RFX6 SCN2A SCN3A SCN8A UNC80	4.92e-07	186	113	7	b45cce768e4bf91da194fd9660cab7520dfb15ac
ToppCell	Fetal_29-31_weeks-Epithelial-lung_neuroendocrine_cell_(PNEC)-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	TCERG1L BRSK2 RFX6 SCN2A SCN3A SCN8A UNC80	5.29e-07	188	113	7	c4c3b21ab723b0e9beff9ec84f8d68485f771528
ToppCell	Somatosensory_Cortex_(S1)-Neuronal\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GRIN2A THRB SCN1A SCN2A SCN3A SCN8A UNC80	7.49e-07	198	113	7	c01091ef18e096d792ea2a7a715764a5b215355f
ToppCell	primary_auditory_cortex_(A1C)-Neuronal\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GRIN2A THRB SCN1A SCN2A SCN3A SCN8A UNC80	7.49e-07	198	113	7	6d18b45eda4014759e6dd282d78ffd28df8a6044
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GRIN2A THRB SCN1A SCN2A SCN3A SCN8A UNC80	7.49e-07	198	113	7	4ca5ff320905ab4ff60ed90a5522227c782142a6
ToppCell	5'-GW_trimst-2-LargeIntestine-Epithelial-neuro-epithelial-EECs\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RFX6 GRIN2A CPT1B CAPN13 SCN3A PNPLA7	4.06e-06	165	113	6	4b4e75ad0eb0a6b00c30a000ec6267e23ba2e496
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Outer_Medullary_Collecting_Duct_Intercalated_Cell_Type_A\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SPIRE1 SCN2A SCN3A SLC4A9 TMEM117 WDR72	4.20e-06	166	113	6	6fe8db8d45177a78605681f22e04fa8d0594f2df
ToppCell	Epithelial-lung_neuroendocrine_cell_(PNEC)\|World / Lineage, Cell type, age group and donor	TCERG1L RFX6 SCN2A SCN3A SCN8A UNC80	7.12e-06	182	113	6	57bf4ffb304324e2e392e196336a530d9f78fe0d
ToppCell	droplet-Heart-4Chambers-18m-Neuronal-cardiac_neuron\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DHX33 XRCC2 LGI4 SCN7A MPZL2 UNC80	7.12e-06	182	113	6	6fdaf3c8c3952a8f14dd7288e523ed58eb1d3517
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Neuronal-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BRSK2 CNNM1 SCN1A SCN2A SCN8A UNC80	8.83e-06	189	113	6	f57200c93d39c9bce1adba0a6a1c178c028dd86b
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SPIRE1 SCN2A SCN3A SLC4A9 TMEM117 WDR72	8.83e-06	189	113	6	532aaf02b364c5c4f58a2021c7c21d86df3875c9
ToppCell	PCW_07-8.5-Epithelial-Epithelial_neuroendo-epi_neuroendocrine1[NE1]_(11)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	TCERG1L RFX6 CNNM1 PPP2R2B SCN3A UNC80	9.10e-06	190	113	6	b1095b2a7467c152d16e4f19a9515aeb61fc9e3d
ToppCell	facs-Brain_Non-Myeloid-Cortex-24m-Neuronal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MATK CNNM1 SCN1A SCN2A SCN8A UNC80	9.95e-06	193	113	6	be28070c049e7cb68bcd54f582226eb2f5e4bc1c
ToppCell	facs-Brain_Non-Myeloid-Cortex-24m-Neuronal-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MATK CNNM1 SCN1A SCN2A SCN8A UNC80	9.95e-06	193	113	6	0c652ebe22ce5d2927599dd97ef1920547858395
ToppCell	facs-Brain_Non-Myeloid-Cortex-24m-Neuronal-neuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MATK CNNM1 SCN1A SCN2A SCN8A UNC80	9.95e-06	193	113	6	8689a70a33a7c3823dc647d41ac0160e7c3ae396
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GRIN2A THRB SCN2A SCN3A SCN8A UNC80	1.09e-05	196	113	6	676c56b44ac29f7baecb62f49bb8597cc74c0a88
ToppCell	Bronchus_Control_(B.)-Endothelial-TX\|Bronchus_Control_(B.) / Sample group, Lineage and Cell type	TCERG1L BRSK2 PPP2R2B SCN2A SCN3A UNC80	1.15e-05	198	113	6	feac39036b5c0ab97b524cc366286942d136d42f
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GRIN2A THRB SCN2A SCN3A SCN8A UNC80	1.15e-05	198	113	6	0ff30edfd3c133a42e8cb96e1631a1143215f808
ToppCell	Bronchus_Control_(B.)-Endothelial-TX-Bronchial_vessel\|Bronchus_Control_(B.) / Sample group, Lineage and Cell type	TCERG1L BRSK2 PPP2R2B SCN2A SCN3A UNC80	1.15e-05	198	113	6	dcf334d13e5b0018fee24febccfef91c9e17843b
ToppCell	Neuronal\|World / cells hierarchy compared to all cells using T-Statistic	GRIN2A THRB SCN2A SCN3A SCN8A UNC80	1.22e-05	200	113	6	48d801219bc771d6c7e151dc88ca4c179988de85
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Transitional_Principal-Intercalated_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	GALNTL6 SCN2A SCN3A SLC4A9 TMEM117	3.56e-05	146	113	5	e887e9de895fd453faa703997ef372cc6410fc49
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	TRIM68 GUCA1B SCN1A SCN2A SCN7A	4.18e-05	151	113	5	f41c6558a5874b6464c157027fdf202257c60e5b
ToppCell	10x_3'_v2v3-Non-neoplastic-Glial-Neuronal-OPC-OPC-E\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	GALNTL6 ASIC1 SCN1A SCN2A SCN3A	4.73e-05	155	113	5	77fdae85d36efb776db977eb424b32487ef222e4
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Cortical_Collecting_Duct_Intercalated_Cell_Type_A\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SPIRE1 SCN2A ADGRA1 SLC4A9 TMEM117	5.50e-05	160	113	5	1e210e526ea4d84fc58a798a26c0929bcb69fd89
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SPIRE1 SCN2A SLC4A9 TMEM117 WDR72	6.19e-05	164	113	5	d847d509bb1791638032ade6755d8164586b5bd5
ToppCell	PND10-Epithelial-Epithelial_Airway-Neurosecretory-Secretory-Secretory_prolif\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	GABRP MAT1A CNNM1 MPZL2 WDR72	6.19e-05	164	113	5	6ea188e17895961cd112152fb111d08641cc5e45
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Connecting_Tubule_Intercalated_Cell_Type_A\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SPIRE1 SCN2A SCN3A SLC4A9 TMEM117	6.37e-05	165	113	5	9bd332e5ede759a00a47728ea5558c215efdd77a
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Intercalated_Cell_Type_B\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	GRIN2A ADGRA1 SLC4A9 TMEM117 WDR72	6.37e-05	165	113	5	dc570154baed59ed109e5369589448e075ba66a9
ToppCell	P15-Epithelial-airway_epithelial_cell-ciliated_cell_of_airway\|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	ERCC2 LGI4 PIK3C2B PNPLA7 CMTR2	6.74e-05	167	113	5	5c3d0763f73628c71c71f9883556bb4f1639f3cc
ToppCell	Children_(3_yrs)-Epithelial-lung_neuroendocrine_cell_(PNEC)-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	AMH TCERG1L RFX6 CNNM1 UNC80	6.74e-05	167	113	5	c87ebfa8c3284ad33579190e148c95bcaf670d17
ToppCell	CV-Mild-7\|CV / Virus stimulation, Condition and Cluster	SPIRE1 TMEM104 ZBED5 CABIN1 FITM2	7.33e-05	170	113	5	25ebde7d2f8ae1afdfaf5876284ff20bb179eb10
ToppCell	ASK454-Epithelial-Transformed_epithelium\|ASK454 / Donor, Lineage and Cell class of Lung cells from Dropseq	PPP2R2D SGCB DDX51 SLC30A5 FITM2	7.75e-05	172	113	5	3986f0f098ef5e096c8d9ee3d335b8404083701f
ToppCell	COVID-19_Mild-PLT_2\|COVID-19_Mild / Disease Group and Platelet Clusters	ERCC4 CLDN12 ULK3 USP35 ATIC	7.96e-05	173	113	5	d11705e56b6b21eec963ea224717f27680c781ed
ToppCell	CV-Mild-7\|Mild / Virus stimulation, Condition and Cluster	SPIRE1 TMEM104 ZBED5 CABIN1 FITM2	7.96e-05	173	113	5	c9bbca9313a0fdf146c8c995624b94b937e818d8
ToppCell	3'-Child04-06-SmallIntestine-Epithelial-neuro-epithelial-EC_cells_(TAC1+)\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CASR RFX6 ADGRG4 SCN2A SCN3A	8.18e-05	174	113	5	a62531ebf16b32b249168dca11b870f63a8aa81c
ToppCell	3'-Child09-12-SmallIntestine-Epithelial-neuro-epithelial\|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RFX6 ADGRG4 SCN2A SCN3A DISP3	8.63e-05	176	113	5	2e1003dc373b14d27f0464d980453fdcfc1005f0
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Intercalated_Cell_Type_B\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	GRIN2A ADGRA1 SLC4A9 TMEM117 WDR72	8.63e-05	176	113	5	6c7edf1cb38644500bce6c5a1dd90bbe17415cdb
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Transitional_Principal-Intercalated_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SPIRE1 SCN2A SCN3A SLC4A9 TMEM117	8.87e-05	177	113	5	f35b04c3557ebbdeba37dec54c8f45880eafb422
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Intercalated_Cell_Type_B\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	GRIN2A ADGRA1 SLC4A9 TMEM117 WDR72	9.10e-05	178	113	5	51d2188406f04329311b2efd1108fc36617a860e
ToppCell	3'-Pediatric_IBD-SmallIntestine-Epithelial-neuro-epithelial-EC_cells_(TAC1+)\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RFX6 ADGRG4 SCN3A DISP3 SLC4A9	9.35e-05	179	113	5	f2e8fc975c30992611630197b79daaeef7c4211d
ToppCell	3'-Child09-12-SmallIntestine-Epithelial-neuro-epithelial-EC_cells_(TAC1+)\|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SCN11A RFX6 ADGRG4 SCN3A DISP3	9.35e-05	179	113	5	8ce5000088b727783a0619baa16a2cd036d21f54
ToppCell	PCW_13-14-Neuronal-Neuronal_postreplicative-neuro_neuronal_(6)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	BRSK2 PPP2R2B SCN1A SCN2A SCN3A	9.35e-05	179	113	5	af0b54c9ea0b6e4210f22dbb6e88ecd3276a5f86
ToppCell	COVID-19-kidney-CD-IC-B\|COVID-19 / Disease (COVID-19 only), tissue and cell type	GRIN2A ADGRA1 SLC4A9 TMEM117 WDR72	1.01e-04	182	113	5	ee6a8c356bbbdae55e4ea858337e079491f9f4aa
ToppCell	droplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Neuronal-cardiac_neuron\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BRSK2 LGI4 PPP2R2B SCN7A TMEM117	1.01e-04	182	113	5	812ff2a50a510b18d865e89465dba1754a08ef61
ToppCell	Control-Epithelial_cells-Airway_mucous\|Control / group, cell type (main and fine annotations)	GABRP PIK3C2B SCN2A SCN3A MGAM2	1.04e-04	183	113	5	15d24a4fb1ffe6cbafbd54fcd7dde9ddcfbe03b2
ToppCell	3'-GW_trimst-1-SmallIntestine-Epithelial-neuro-epithelial-K_cells_(GIP+)\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CASR RFX6 CNBD2 ADGRG4 ADGRA1	1.04e-04	183	113	5	d23018193b9c0806e0d1a9ac15e6392eb8e96aaf
ToppCell	PND10-Epithelial-Epithelial_Airway-Neurosecretory-Secretory-Secretory_mature\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	GALNTL6 GABRP CAPN13 PPP2R2B WDR72	1.04e-04	183	113	5	514b72a1ae55656934839800513385e19bc240e2
ToppCell	PND10-Epithelial-Epithelial_Airway-Neurosecretory\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	GALNTL6 GABRP CAPN13 PPP2R2B WDR72	1.06e-04	184	113	5	49eccf72725593a8fb4a529e7985a5c413b3ca6a
ToppCell	PND10-Epithelial-Epithelial_Airway-Neurosecretory-Secretory\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	GALNTL6 GABRP CAPN13 PPP2R2B WDR72	1.06e-04	184	113	5	41164109d9d7bb1c431220e2e85e08dc5f56856d
ToppCell	wk_15-18-Epithelial-Proximal_epithelial-intermediate_neuroendocrine\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	TCERG1L BRSK2 RFX6 ANKRD24 UNC80	1.06e-04	184	113	5	9e5f98f9113e5e38bdadba6d9d2c346177fb35fe
ToppCell	facs-Large_Intestine-Proximal-24m-Epithelial-enteroendocrine_cell\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RFX6 ATP8B2 SCN3A SCN8A DMWD	1.09e-04	185	113	5	2a8104f610fa5ce618f8105521616722462a0d42
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SPIRE1 SCN2A SCN3A SLC4A9 TMEM117	1.09e-04	185	113	5	3d73b3e0bceb192257e5cfbe64b7ccb379b6e22d
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	SPIRE1 CASR LYST SCN2A SCN3A	1.15e-04	187	113	5	77886f99c229610abd28c4c370d2c7d1536c9782
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SPIRE1 SCN2A SCN3A SLC4A9 TMEM117	1.15e-04	187	113	5	2d17408b3b5f09d135084fd7ccce98e6b5ca632b
ToppCell	COVID-19-kidney-CD-IC-B\|kidney / Disease (COVID-19 only), tissue and cell type	GRIN2A ADGRA1 SLC4A9 TMEM117 WDR72	1.15e-04	187	113	5	ce05b89860573fe0356102e2998d1ef6d1968034
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SPIRE1 THRB SCN2A SCN3A SSH2	1.15e-04	187	113	5	e3095455d2f255854f339f6b05fa87852af0700f
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	SPIRE1 SCN2A SLC4A9 TMEM117 WDR72	1.18e-04	188	113	5	58ccb31cdf43167872ef0fc737e6f9c51ee2e060
ToppCell	LA-12._Cytoplasmic_Cardiomyocyte_II\|World / Chamber and Cluster_Paper	ABCA2 RFX6 CNBD2 SCN2A	1.18e-04	99	113	4	aed68765f60e54b7e2406c5f09fa744fcd844354
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SPIRE1 SCN2A SCN3A SLC4A9 TMEM117	1.21e-04	189	113	5	a9864873b19ab3e60acf11f288fa7275badc2e42
ToppCell	Globus_pallidus-Neuronal\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	GRIN2A CNNM1 SCN2A SCN8A UNC80	1.24e-04	190	113	5	416de85d8841dac883faa6f5339b2fb461a09e82
ToppCell	Entopeduncular-Neuronal\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	GRIN2A CNNM1 SCN2A SCN8A UNC80	1.30e-04	192	113	5	4c35e5c28a40b439044797ba1f06cb7c36b2a8de
ToppCell	Neuroendocrine\|World / Class top	TCERG1L SCN3A SCN8A UNC80 TMEM117	1.30e-04	192	113	5	0199da3ef9ddb6673e9aa41f346f374838aec182
ToppCell	Posterior_cortex-Neuronal\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	MATK CNNM1 SCN2A SCN8A UNC80	1.33e-04	193	113	5	b4989e3436e84dbec3789b46057e0f7a0ebf09d4
ToppCell	severe-B_cell\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	ITGA2B THRB SCN2A SCN3A PNPLA7	1.36e-04	194	113	5	2fee6083fb56b16d1f04fd0b92ec622fd26ba3fa
ToppCell	Bronchial-NucSeq-Epithelial-Epi_airway_neuro-secretory\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	TCERG1L RFX6 SCN2A SLC4A9 UNC80	1.36e-04	194	113	5	2dcc3b99dbedaf8a6916891c85091ddb79d7ee31
ToppCell	LA-12._Cytoplasmic_Cardiomyocyte_II\|LA / Chamber and Cluster_Paper	ABCA2 RFX6 CNBD2 SCN2A	1.38e-04	103	113	4	e457f25e65a62c94685b15cd73fd3278fb94bf9c
ToppCell	PCW_13-14-Epithelial-Epithelial_neuroendo-epi_neuroendocrine1[NE1]_(11)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	TCERG1L RFX6 PPP2R2B SCN3A UNC80	1.40e-04	195	113	5	5f33ece997f074598b4201ff74f592ee07c86a06
ToppCell	Bronchial-NucSeq-Epithelial-Epi_airway_neuro-secretory-Neuroendocrine\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	TCERG1L RFX6 SCN2A SCN3A UNC80	1.43e-04	196	113	5	4bdc304c0c9d8bebe1a6a8a27e44acd1e8113725
ToppCell	Bronchial-NucSeq-Stromal-Schwann\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	LGI4 PPP2R2B MICALL2 SCN7A UNC80	1.43e-04	196	113	5	a90c76d9c57a4491b94a321ba541b792ec5d8e83
ToppCell	Bronchial-NucSeq-Stromal-Schwann-Schwann_nonmyelinating\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	LGI4 PPP2R2B MICALL2 SCN7A UNC80	1.46e-04	197	113	5	4a7ff67bb0754e034e6f2a1bd34cde86ee3ef899
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GRIN2A SCN1A SCN2A SCN8A UNC80	1.50e-04	198	113	5	8ab40fae14fe02e39bc8c8da187a5cd60c787643
ToppCell	Parenchymal-10x5prime-Epithelial-Epi_airway_neuro-secretory-Neuroendocrine\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	TCERG1L CAPN13 CNNM1 SCN2A SCN3A	1.50e-04	198	113	5	d6812494874be0c14361ac2ac3e418b335bb8f55
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-OPC-OPC-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ASIC1 SCN1A SCN2A ADGRA1 UNC80	1.53e-04	199	113	5	19a97e27a4758e794ce7246d295e112b47931a48
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW26\|organoid_Tanaka_cellReport / Sample Type, Dataset, Time_group, and Cell type.	MATK LGI4 THRB SCN2A ANKRD24	1.57e-04	200	113	5	5c7263c862093ad9dbc81d06b16b6f74e8a6b634
ToppCell	Cerebellum-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Pvalb-Inhibitory_Neuron.Gad1Gad2.Pvalb-Nefh_(Cerebellum_basket_cells_1)\|Cerebellum / BrainAtlas - Mouse McCarroll V32	GALNTL6 UTS2R RFX6	2.31e-04	47	113	3	59811807a4b5baec55505bb4c38ac684b0a49c9a
ToppCell	Cerebellum-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Pvalb-Inhibitory_Neuron.Gad1Gad2.Pvalb-Nefh_(Cerebellum_basket_cells_1)-\|Cerebellum / BrainAtlas - Mouse McCarroll V32	GALNTL6 UTS2R RFX6	2.31e-04	47	113	3	74ed0dc55bcfe6e5f7bab42ee060692d51a39e5a
Drug	Zonisamide	SCN11A SCN1A SCN2A SCN3A	1.26e-06	17	112	4	DB00909
Drug	APETx1, Anthopleura elegantissima	SCN2A SCN3A SCN8A	2.29e-06	6	112	3	ctd:C475726
Drug	2,3,5,6-tetrafluoro-4-methylbenzyl (Z)-(1RS)-cis-3-(2-chloro-3,3,3-trifluoroprop-1-enyl)-2,2-dimethylcyclopropanecarboxylate	SCN2A SCN3A SCN8A	6.37e-06	8	112	3	ctd:C489827
Disease	generalized epilepsy with febrile seizures plus 2 (implicated_via_orthology)	SCN11A SCN1A SCN2A SCN3A SCN7A SCN8A	5.72e-13	10	113	6	DOID:0111294 (implicated_via_orthology)
Disease	Dravet syndrome (implicated_via_orthology)	SCN11A SCN1A SCN2A SCN3A SCN7A SCN8A	5.72e-13	10	113	6	DOID:0080422 (implicated_via_orthology)
Disease	generalized epilepsy with febrile seizures plus (implicated_via_orthology)	SCN11A SCN1A SCN2A SCN3A SCN7A SCN8A	2.50e-12	12	113	6	DOID:0060170 (implicated_via_orthology)
Disease	epilepsy (implicated_via_orthology)	SCN11A GRIN2A SCN1A SCN2A SCN3A SCN7A SCN8A	3.26e-06	163	113	7	DOID:1826 (implicated_via_orthology)
Disease	autosomal recessive congenital ichthyosis (is_implicated_in)	ERCC2 CASP14	1.45e-05	2	113	2	DOID:0060655 (is_implicated_in)
Disease	Siddiqi syndrome (implicated_via_orthology)	FITM1 FITM2	1.45e-05	2	113	2	DOID:0081273 (implicated_via_orthology)
Disease	lipid metabolism disorder (implicated_via_orthology)	MAT1A FITM1 FITM2	2.41e-05	15	113	3	DOID:3146 (implicated_via_orthology)
Disease	Benign familial infantile epilepsy	SCN2A SCN8A	4.35e-05	3	113	2	cv:C5575231
Disease	anxiety disorder (implicated_via_orthology)	SCN1A SCN2A SCN3A	7.99e-05	22	113	3	DOID:2030 (implicated_via_orthology)
Disease	xeroderma pigmentosum (is_implicated_in)	ERCC2 ERCC4	2.16e-04	6	113	2	DOID:0050427 (is_implicated_in)
Disease	xeroderma pigmentosum (implicated_via_orthology)	ERCC2 ERCC4	2.16e-04	6	113	2	DOID:0050427 (implicated_via_orthology)
Disease	Familial benign neonatal epilepsy	SCN2A SCN8A	2.16e-04	6	113	2	C0220669
Disease	Cockayne syndrome (implicated_via_orthology)	ERCC2 ERCC4	2.16e-04	6	113	2	DOID:2962 (implicated_via_orthology)
Disease	Epilepsy, Cryptogenic	GRIN2A SCN1A SCN2A SCN8A	2.83e-04	82	113	4	C0086237
Disease	Awakening Epilepsy	GRIN2A SCN1A SCN2A SCN8A	2.83e-04	82	113	4	C0751111
Disease	Aura	GRIN2A SCN1A SCN2A SCN8A	2.83e-04	82	113	4	C0236018
Disease	Seizure, Febrile, Simple	SCN1A SCN2A	3.01e-04	7	113	2	C0149886
Disease	Seizure, Febrile, Complex	SCN1A SCN2A	3.01e-04	7	113	2	C0751057
Disease	peripheral neuropathy	GALNTL6 SCN7A	3.01e-04	7	113	2	EFO_0003100
Disease	Intellectual Disability	BRSK2 LGI4 CTCF SCN1A SCN3A SCN8A ATIC ZBTB11	3.33e-04	447	113	8	C3714756
Disease	melanoma	ERCC2 ERCC4 RFX6 GRIN2A TERT CNNM1	3.96e-04	248	113	6	C0025202
Disease	Neurodevelopmental Disorders	BRSK2 SCN1A SCN2A SCN8A	4.58e-04	93	113	4	C1535926
Disease	Xeroderma pigmentosum	ERCC2 ERCC4	5.14e-04	9	113	2	cv:C0043346
Disease	Febrile Convulsions	SCN1A SCN2A	5.14e-04	9	113	2	C0009952
Disease	Generalized Epilepsy with Febrile Seizures Plus	SCN1A SCN2A	5.14e-04	9	113	2	C3502809
Disease	Basal cell carcinoma	ERCC2 ERCC4	7.82e-04	11	113	2	C0007117
Disease	Epilepsy	GRIN2A SCN1A SCN2A SCN8A	8.33e-04	109	113	4	C0014544
Disease	autosomal dominant cerebellar ataxia (implicated_via_orthology)	PPP2R2D PPP2R2B	9.36e-04	12	113	2	DOID:1441 (implicated_via_orthology)
Disease	Amino Acid Metabolism, Inherited Disorders	MAT1A PRODH	1.10e-03	13	113	2	C0750905
Disease	Infantile Severe Myoclonic Epilepsy	SCN1A SCN2A	1.10e-03	13	113	2	C0751122
Disease	Amino Acid Metabolism, Inborn Errors	MAT1A PRODH	1.10e-03	13	113	2	C0002514
Disease	Hermansky-Pudlak syndrome (implicated_via_orthology)	CCZ1B CCZ1	1.28e-03	14	113	2	DOID:3753 (implicated_via_orthology)
Disease	ovarian carcinoma (is_implicated_in)	AMH CABIN1	1.48e-03	15	113	2	DOID:4001 (is_implicated_in)
Disease	MMR-related febrile seizures	SCN1A SCN2A	1.48e-03	15	113	2	EFO_0006519
Disease	Early infantile epileptic encephalopathy with suppression bursts	SCN1A SCN2A	1.68e-03	16	113	2	C0393706
Disease	Febrile seizure (within the age range of 3 months to 6 years)	SCN1A SCN2A	2.14e-03	18	113	2	HP_0002373
Disease	renal system measurement	MICALL2 WDR72	2.64e-03	20	113	2	EFO_0004742

Protein segments in the cluster

Peptide	Gene	Start	Entry
LETDILFGHRCGMTT	BARGIN	621	Q6ZT62
GAGFHLDLFCVAVLM	SLC4A9	751	Q96Q91
DMRASALCDRHTKFF	PPP2R2B	251	Q00005
AVHDFGLFMSLIVSC	DISP3	586	Q9P2K9
VLFLLSMDFTCHADL	BIRC6	2336	Q9NR09
DCDMAFVTSGELVRH	CTCF	326	P49711
LAVLRGDHTFDGMAF	ADGRG4	2566	Q8IZF6
IFITCHEGSLMALGF	CASR	761	P41180
AVSQGHFLDMVFSCL	ADGRA1	276	Q86SQ6
LGHFMLRCLTTDEYD	BLVRB	181	P30043
FTRFMAGLIFVLHSC	CMTR2	651	Q8IYT2
LAMTGSGIDRHLFCL	CPT1A	646	P50416
DMRSSALCDRHSKFF	PPP2R2D	261	Q66LE6
FTTLRDHCLSMGRTF	CAPN13	21	Q6MZZ7
DHCLSMGRTFKDETF	CAPN13	26	Q6MZZ7
MIHSLFLINCSGDIF	AP3M1	1	Q9Y2T2
FHLAAMRGAASCLEV	ANKRD24	86	Q8TF21
GCLRVFHFDSMLLRG	DMWD	306	Q09019
FFRLLSLCHTVMSEE	ATP8B2	486	P98198
AFAREHGLIFMETSA	RAB2A	136	P61019
AFAREHGLIFMETSA	RAB2B	136	Q8WUD1
FLGVDFSSLDMSLCV	QSOX2	651	Q6ZRP7
SSFGSFHLIRMLLDE	RFX6	516	Q8HWS3
RLSCSDLFIHRMISF	OR9K2	211	Q8NGE7
DLFIHRMISFSLSCI	OR9K2	216	Q8NGE7
FFIHLCTGMESAVLV	OR52E1	101	Q8NGJ3
GHLTIDEAVFFCNLM	MATK	176	P42679
LLFARTLCMDTEFHG	MGAM2	511	Q2M2H8
DVLDSMHSLGCFRDR	BRSK2	301	Q8IWQ3
TCAFDHGLEMRTILA	JADE2	336	Q9NQC1
MTTSFRDGLAFCAIL	MICALL2	26	Q8IY33
EGTCSDMDFLIALAH	EFHC2	611	Q5JST6
VLLAMAFDRFVAICH	OR51L1	116	Q8NGJ5
VLFGLFESREMQHTC	OR4S1	11	Q8NGB4
RMGELFECVLFTASL	CTDSP1	141	Q9GZU7
DGLCDHSLSEGVFMF	MAT1A	6	Q00266
FLTFDAMRHAAQCVG	ERCC2	651	P18074
FLNTTFLLMGCAREH	LYPD4	181	Q6UWN0
IHFLALAIGSACALM	MPZL2	151	O60487
QALLFGDDHRCFTRM	AMH	231	P03971
ALVFMDECHATGFLG	GCAT	226	O75600
SDLGMACDRARVFLH	PNPLA7	391	Q6ZV29
LLLGTMAFDHFVAIC	OR1S2	126	Q8NGQ3
VAAFCHMLDILRSGS	PIK3C2B	336	O00750
MLFHGTSSEFVEAIC	PARP11	201	Q9NR21
LCTSGFDRAKHLEFM	CABIN1	716	Q9Y6J0
EGRLEFASMFDTIHA	CPLANE1	541	Q9H799
LHLVLEMGFSRVLCF	DDX51	496	Q8N8A6
HTFLLTFCCLLMAEE	FITM1	186	A5D6W6
DISGHSFLLTFCALM	FITM2	151	Q8N6M3
HLLTQCFSETFGERM	DHX57	216	Q6P158
FMIDASVHPTLDFCR	CCZ1	326	P86791
FMIDASVHPTLDFCR	CCZ1B	326	P86790
DVESVRRCLAHSLFM	DHX33	616	Q9H6R0
GESRLLAARFFDSMC	ABCA2	1561	Q9BZC7
LASEGSACLDMFEHI	CYP4F2	181	P78329
HRGTQELLECFIEMF	LYST	2386	Q99698
ELLECFIEMFFGRHI	LYST	2391	Q99698
SLRVCFLLFESMREH	GBF1	476	Q92538
HALAMDYRSLGFREC	HEY1	116	Q9Y5J3
MGCRDVHAATVLSFL	CLDN12	1	P56749
CAFVVLMAHGREGFL	CASP14	81	P31944
QRTMFVGIDCFHDIV	PIWIL3	646	Q7Z3Z3
LAMTGAGIDRHLFCL	CPT1B	646	Q92523
HLAFVCLSLFTERMC	GABRP	6	O00591
ARIEALGGFVSHMDC	PPM1F	301	P49593
GSTECFFLAVMAFDR	OR11G2	146	Q8NGC1
RGLMIEACAHATFFC	NOXRED1	31	Q6NXP6
MARLSFCVTGEIAHF	OR1N1	161	Q8NGS0
IHCFATVESGIFLAM	OR52M1	106	Q8NGK5
SMARGEVLTFLDSHC	GALNTL6	221	Q49A17
HDIDVGRFQTLMECF	THADA	781	Q6YHU6
TACGRSLFLFDEMDK	TOR2A	151	Q8N2E6
LFELCGRAVSAHMGV	LRRC41	46	Q15345
AHITMAGRRFLFAAC	LGI4	506	Q8N135
ECPSGTLFMHEFKRF	GUCA1B	31	Q9UMX6
HMETFLRCIEASGRV	PRODH	211	O43272
SIREFLCSEAMFHLG	SELENOO	196	Q9BVL4
MVSGDRIHCLDILFA	SCN3A	1841	Q9NY46
CHTTMAFLRDEADFR	ITGA2B	576	P08514
GCDSMEFHESGLLRF	SGCB	96	Q16585
ISGMRSHCEIAVFID	TRPT1	166	Q86TN4
MVSGDRIHCLDILFA	SCN1A	1856	P35498
IEHMFRGDLCYLLTS	SMCR8	341	Q8TEV9
AGHDIRDMLLSCHFR	ASIC1	161	P78348
CRVFSHKGMFSFEDV	CIB4	71	A0PJX0
CFGEMDVLHASVRRS	CNBD2	186	Q96M20
LGDCFMLRSDAVLDF	CNNM1	436	Q9NRU3
HFRDMLLERGVSAFS	TCERG1L	456	Q5VWI1
TACGRSLFLFDEMDK	TOR2A	151	Q5JU69
DLSLCHIRGLSSMFR	TRIML2	231	Q8N7C3
AMLFVCSRSGHILEI	WDR90	571	Q96KV7
DFCSMADVAILARHL	ZBTB11	281	O95625
TFLREPMSIDCGHSF	TRIM68	21	Q6AZZ1
FLHALLGFCMEPVTD	UNC80	861	Q8N2C7
ASRGLLDAAHFCYLM	SEC16A	1731	O15027
RMICLEFTSREFHAG	SSH2	526	Q76I76
CRALFAETMELHTFL	SPIRE1	221	Q08AE8
LQALFMASDFRHCVL	USP35	456	Q9P2H5
TDLRMIGACHASRFL	THRB	426	P10828
MVSGDRIHCLDILFA	SCN2A	1846	Q99250
LSFTAIFCFRGDSLM	TMEM104	321	Q8NE00
LACRVGSSFRMESIH	WDR72	921	Q3MJ13
MVSGDRIHCLDILFA	SCN8A	1836	Q9UQD0
RCESGALMHSFGIFL	STIMATE	26	Q86TL2
RMSSFGDFVALSDVC	ATIC	311	P31939
MCSAFHRAESGTELL	XRCC2	1	O43543
VGCRVLFGLDFLTMH	UTS2R	121	Q9UKP6
LLVFMDSAFRLSDCL	ZBED5	451	Q49AG3
ISDGFHMLFDCSALV	SLC30A5	446	Q8TAD4
IFDSMIVFHGLIELC	SCN7A	571	Q01118
SEDRLHCMDILFAFT	SCN11A	1676	Q9UI33
HCMDILFAFTARVLG	SCN11A	1681	Q9UI33
EGDMFLHSRFIGASL	TMEM117	376	Q9H0C3
FDTGFCHVERVMRNL	ERCC4	171	Q92889
LDMAHCIRTFTEEIS	TRIM23	231	P36406
RLHFCDTMELFIETL	ZFAND4	21	Q86XD8
ASSGLFDVFLRFMCH	TERT	801	O14746
MEFCAGGDLSRFIHT	ULK3	91	Q6PHR2
VCDLMSGARIHGLVF	GRIN2A	86	Q12879