Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	modified amino acid transmembrane transporter activity	SLC5A6 SLC22A15 SLC6A14	1.26e-04	33	59	3	GO:0072349
GeneOntologyMolecularFunction	ubiquitin-protein transferase activity	TRAF3 LNX2 SIAH1 ZNRF4 SH3RF3 RNF138 WDR24	4.71e-04	473	59	7	GO:0004842
GeneOntologyMolecularFunction	semaphorin receptor activity	PLXNA3 MET	5.56e-04	12	59	2	GO:0017154
GeneOntologyMolecularFunction	ubiquitin-like protein transferase activity	TRAF3 LNX2 SIAH1 ZNRF4 SH3RF3 RNF138 WDR24	7.53e-04	512	59	7	GO:0019787
GeneOntologyMolecularFunction	ubiquitin protein ligase activity	TRAF3 SIAH1 ZNRF4 SH3RF3 RNF138 WDR24	7.87e-04	372	59	6	GO:0061630
GeneOntologyMolecularFunction	quaternary ammonium group transmembrane transporter activity	SLC22A15 SLC6A14	8.79e-04	15	59	2	GO:0015651
GeneOntologyMolecularFunction	aminoacyltransferase activity	TRAF3 LNX2 SIAH1 ZNRF4 SH3RF3 RNF138 WDR24	9.42e-04	532	59	7	GO:0016755
GeneOntologyMolecularFunction	ubiquitin-like protein ligase activity	TRAF3 SIAH1 ZNRF4 SH3RF3 RNF138 WDR24	1.12e-03	398	59	6	GO:0061659
Domain	ZF_RING_1	TRAF3 LNX2 SIAH1 ZNRF4 RNF207 SH3RF3 RNF138	3.16e-05	291	58	7	PS00518
Domain	ZF_RING_2	TRAF3 LNX2 SIAH1 ZNRF4 RNF207 SH3RF3 RNF138	3.68e-05	298	58	7	PS50089
Domain	RING	TRAF3 LNX2 SIAH1 ZNRF4 RNF207 SH3RF3 RNF138	4.26e-05	305	58	7	SM00184
Domain	Znf_RING	TRAF3 LNX2 SIAH1 ZNRF4 RNF207 SH3RF3 RNF138	6.48e-05	326	58	7	IPR001841
Domain	IPT	PLXNA3 MET PKHD1	7.88e-05	27	58	3	SM00429
Domain	TIG	PLXNA3 MET PKHD1	1.20e-04	31	58	3	PF01833
Domain	IPT	PLXNA3 MET PKHD1	1.32e-04	32	58	3	IPR002909
Domain	Ig_E-set	PLXNA3 MET POGLUT3 PKHD1	3.06e-04	104	58	4	IPR014756
Domain	-	TRAF3 LNX2 SIAH1 ZNRF4 RNF207 SH3RF3 RNF138	4.62e-04	449	58	7	3.30.40.10
Domain	Znf_RING/FYVE/PHD	TRAF3 LNX2 SIAH1 ZNRF4 RNF207 SH3RF3 RNF138	5.27e-04	459	58	7	IPR013083
Domain	TIL	TECTA OTOG	6.13e-04	12	58	2	PF01826
Domain	C8	TECTA OTOG	6.13e-04	12	58	2	PF08742
Domain	Unchr_dom_Cys-rich	TECTA OTOG	7.23e-04	13	58	2	IPR014853
Domain	C8	TECTA OTOG	7.23e-04	13	58	2	SM00832
Domain	-	RORC RERE NR1I3	7.38e-04	57	58	3	3.30.50.10
Domain	Znf_NHR/GATA	RORC RERE NR1I3	7.77e-04	58	58	3	IPR013088
Domain	Znf_C2H2	RLF ZNF28 SALL1 ZNF813 ZNF525 ZNF761 ZFPM1 ZNF468 RNF138	7.84e-04	805	58	9	IPR007087
Domain	ZnF_C2H2	RLF ZNF28 SALL1 ZNF813 ZNF525 ZNF761 ZFPM1 ZNF468 RNF138	8.05e-04	808	58	9	SM00355
Domain	TIL_dom	TECTA OTOG	8.42e-04	14	58	2	IPR002919
Domain	-	TRAF3 SIAH1	8.42e-04	14	58	2	3.90.890.10
Domain	-	TRAF3 SIAH1	8.42e-04	14	58	2	2.60.210.10
Domain	SIAH-type	TRAF3 SIAH1	1.11e-03	16	58	2	IPR013323
Domain	VWD	TECTA OTOG	1.11e-03	16	58	2	SM00216
Domain	VWF_type-D	TECTA OTOG	1.11e-03	16	58	2	IPR001846
Domain	VWFD	TECTA OTOG	1.11e-03	16	58	2	PS51233
Domain	VWD	TECTA OTOG	1.11e-03	16	58	2	PF00094
Domain	zf-C2H2	RLF ZNF28 SALL1 ZNF813 ZNF525 ZNF761 ZFPM1 ZNF468	1.28e-03	693	58	8	PF00096
Domain	VWC_out	TECTA OTOG	1.57e-03	19	58	2	SM00215
Domain	Znf_RING_CS	TRAF3 LNX2 RNF207 SH3RF3	1.64e-03	163	58	4	IPR017907
Domain	TRAF-like	TRAF3 SIAH1	2.50e-03	24	58	2	IPR008974
Domain	ZINC_FINGER_C2H2_2	RLF ZNF28 SALL1 ZNF813 ZNF525 ZNF761 ZFPM1 ZNF468	2.59e-03	775	58	8	PS50157
Domain	ZINC_FINGER_C2H2_1	RLF ZNF28 SALL1 ZNF813 ZNF525 ZNF761 ZFPM1 ZNF468	2.63e-03	777	58	8	PS00028
Domain	Znf_C2H2-like	RLF ZNF28 SALL1 ZNF813 ZNF761 ZFPM1 ZNF468 RNF138	3.05e-03	796	58	8	IPR015880
Domain	Sema	PLXNA3 MET	4.16e-03	31	58	2	SM00630
Domain	Semap_dom	PLXNA3 MET	4.16e-03	31	58	2	IPR001627
Domain	Sema	PLXNA3 MET	4.16e-03	31	58	2	PF01403
Domain	SEMA	PLXNA3 MET	4.16e-03	31	58	2	PS51004
Domain	PSI	PLXNA3 MET	4.43e-03	32	58	2	PF01437
Domain	Plexin_repeat	PLXNA3 MET	4.43e-03	32	58	2	IPR002165
Domain	-	RLF ZNF28 SALL1 ZNF813 ZNF761 ZFPM1 ZNF468	4.89e-03	679	58	7	3.30.160.60
Domain	zf-C3HC4	LNX2 ZNRF4 RNF207 RNF138	5.07e-03	223	58	4	PF00097
Domain	Znf_C2H2/integrase_DNA-bd	RLF ZNF28 SALL1 ZNF813 ZNF761 ZFPM1 ZNF468	5.51e-03	694	58	7	IPR013087
Pubmed	The alpha1beta1 integrin and TNF receptor II protect airway CD8+ effector T cells from apoptosis during influenza infection.	ITGA1 TNFRSF1B	2.83e-06	2	59	2	17911590
Pubmed	Mammalian Auditory Hair Cell Bundle Stiffness Affects Frequency Tuning by Increasing Coupling along the Length of the Cochlea.	TRIOBP TECTA	8.48e-06	3	59	2	29874579
Pubmed	MET is required for the recruitment of anti-tumoural neutrophils.	MET TNFRSF1B	8.48e-06	3	59	2	25985180
Pubmed	P75 Involved in the Ubiquitination of α-synuclein in Rotenone-based Parkinson's Disease Models.	SIAH1 TNFRSF1B	1.69e-05	4	59	2	30081046
Pubmed	A tectorin-based matrix and planar cell polarity genes are required for normal collagen-fibril orientation in the developing tectorial membrane.	TECTA OTOG	1.69e-05	4	59	2	28935705
Pubmed	NIK signaling axis regulates dendritic cell function in intestinal immunity and homeostasis.	RORC TNFRSF1B	2.82e-05	5	59	2	30250187
Pubmed	Binding sites of cytoplasmic effectors TRAF1, 2, and 3 on CD30 and other members of the TNF receptor superfamily.	TRAF3 TNFRSF1B	4.23e-05	6	59	2	9168896
Pubmed	I-TRAF is a novel TRAF-interacting protein that regulates TRAF-mediated signal transduction.	TRAF3 TNFRSF1B	4.23e-05	6	59	2	8710854
Pubmed	Herpesvirus entry mediator, a member of the tumor necrosis factor receptor (TNFR) family, interacts with members of the TNFR-associated factor family and activates the transcription factors NF-kappaB and AP-1.	TRAF3 TNFRSF1B	5.91e-05	7	59	2	9162022
Pubmed	The Epstein-Barr virus transforming protein LMP1 engages signaling proteins for the tumor necrosis factor receptor family.	TRAF3 TNFRSF1B	7.87e-05	8	59	2	7859281
Pubmed	TTRAP, a novel protein that associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor-associated factors (TRAFs), and that inhibits nuclear factor-kappa B activation.	TRAF3 TNFRSF1B	7.87e-05	8	59	2	10764746
Pubmed	Triptolide attenuates inhibition of ankylosing spondylitis-derived mesenchymal stem cells on the osteoclastogenesis through modulating exosomal transfer of circ-0110634.	TRAF3 TNFRSF1B	7.87e-05	8	59	2	36185580
Pubmed	Otogelin, otogelin-like, and stereocilin form links connecting outer hair cell stereocilia to each other and the tectorial membrane.	TECTA OTOG	1.54e-04	11	59	2	31776257
Pubmed	The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.	RLF ZNF28 MARS1 SLC5A6 ZNF813 ZNF525 RERE ZNF468 CCNY	1.82e-04	1203	59	9	29180619
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	RLF DCAF6 KCND3 MARS1 TRIOBP RERE TECTA NAALADL2 SH3RF3 CCNY	1.86e-04	1489	59	10	28611215
Pubmed	A genome-wide association study of optic disc parameters.	SALL1 RERE	2.54e-04	14	59	2	20548946
Pubmed	Inflammation-induced formation of fat-associated lymphoid clusters.	RORC TNFRSF1B	2.54e-04	14	59	2	26147686
Pubmed	RelA and RelB transcription factors in distinct thymocyte populations control lymphotoxin-dependent interleukin-17 production in γδ T cells.	RORC TNFRSF1B	2.54e-04	14	59	2	21419662
Pubmed	Dysplastic definitive hematopoiesis in AML1/EVI1 knock-in embryos.	CSF2RA ZFPM1	3.34e-04	16	59	2	15914564
Pubmed	A diverse family of proteins containing tumor necrosis factor receptor-associated factor domains.	TRAF3 TNFRSF1B	3.34e-04	16	59	2	11279055
Pubmed	Genetic determinants of P wave duration and PR segment.	MET KCND3	3.79e-04	17	59	2	24850809
Pubmed	Mammalian Otolin: a multimeric glycoprotein specific to the inner ear that interacts with otoconial matrix protein Otoconin-90 and Cerebellin-1.	TECTA OTOG	3.79e-04	17	59	2	20856818
Pubmed	The planar cell polarity gene Vangl2 is required for mammalian kidney-branching morphogenesis and glomerular maturation.	MET SALL1 PKHD1	5.74e-04	95	59	3	20843830
Pubmed	Analysis of FGF20-regulated genes in organ of Corti progenitors by translating ribosome affinity purification.	SALL1 TECTA	5.82e-04	21	59	2	32492250
Pubmed	Meta-analysis of genome-wide association studies identifies novel loci that influence cupping and the glaucomatous process.	SALL1 RERE	6.39e-04	22	59	2	25241763
Pubmed	Confirmation of multiple Crohn's disease susceptibility loci in a large Dutch-Belgian cohort.	TNFRSF1B CCNY	6.39e-04	22	59	2	19174780
Pubmed	PRDM16 expression and function in mammalian cochlear development.	SALL1 TECTA	7.00e-04	23	59	2	35451126
Pubmed	Continued expression of GATA3 is necessary for cochlear neurosensory development.	TRIOBP TECTA	7.62e-04	24	59	2	23614009
Pubmed	Systematic analysis of dimeric E3-RING interactions reveals increased combinatorial complexity in human ubiquitination networks.	LNX2 SIAH1 RNF138	7.69e-04	105	59	3	22493164
Pubmed	Retinoic acid deficiency impairs the vestibular function.	TECTA OTOG	8.96e-04	26	59	2	23536097
Pubmed	Genetic risk profiling and prediction of disease course in Crohn's disease patients.	TNFRSF1B CCNY	1.04e-03	28	59	2	19422935
Pubmed	Novel splice variants derived from the receptor tyrosine kinase superfamily are potential therapeutics for rheumatoid arthritis.	MET TNFRSF1B	1.04e-03	28	59	2	18593464
Pubmed	Developmental gene expression profiling along the tonotopic axis of the mouse cochlea.	TECTA OTOG	1.04e-03	28	59	2	22808246
Pubmed	TBX1 is required for normal stria vascularis and semicircular canal development.	RNF138 OTOG	1.27e-03	31	59	2	31550482
Cytoband	19q13.42	ZNF813 KIR3DL3 ZNF525 ZNF761	1.98e-05	125	58	4	19q13.42
Cytoband	19q13.41	ZNF28 ZNF888 ZNF468	1.36e-04	78	58	3	19q13.41
Cytoband	Ensembl 112 genes in cytogenetic band chr19q13	ZNF28 ZNF813 KIR3DL3 ZNF888 ZNF525 ZNF761 ZNF468	7.41e-04	1192	58	7	chr19q13
Cytoband	11q22.3	POGLUT3 ZC3H12C	1.43e-03	44	58	2	11q22.3
Cytoband	5q11.2	ITGA1 DHX29	2.00e-03	52	58	2	5q11.2
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	RLF ZNF28 SALL1 ZNF813 ZNF888 ZNF525 ZNF761 ZFPM1 ZNF468	8.21e-05	718	47	9	28
GeneFamily	Ring finger proteins	LNX2 ZNRF4 RNF207 SH3RF3 RNF138	7.14e-04	275	47	5	58
GeneFamily	Actins\|Deafness associated genes	MET TRIOBP TECTA	3.16e-03	113	47	3	1152
Coexpression	GSE45365_NK_CELL_VS_CD8_TCELL_MCMV_INFECTION_DN	SOCS2 DCAF6 CSF2RA SLC5A6 TNFRSF1B MED13L	4.81e-06	200	57	6	M9961
Disease	serum gamma-glutamyl transferase measurement	MET WWC2 TRAF3 SALL1 PKHD1 TRIOBP RORC ZFPM1 ITGA1 NR1I3	4.51e-06	914	53	10	EFO_0004532
Disease	pulmonary alveolar proteinosis (implicated_via_orthology)	CSF2RA MARS1	3.15e-05	5	53	2	DOID:12120 (implicated_via_orthology)
Disease	blood osmolality measurement	PKHD1 NAALADL2 NDUFV2	1.57e-04	58	53	3	EFO_0007967
Disease	glaucoma	PKHD1 TRIOBP PF4 SRBD1	1.71e-04	154	53	4	MONDO_0005041
Disease	Hypersensitivity	CSF2RA PF4 TNFRSF1B	2.11e-04	64	53	3	C0020517
Disease	response to alcohol	WWC2 PKHD1 NAALADL2	3.37e-04	75	53	3	EFO_0005526
Disease	Nonsyndromic Deafness	MET TECTA OTOG	4.23e-04	81	53	3	C3711374
Disease	aspartate aminotransferase measurement, serum alanine aminotransferase measurement, low density lipoprotein triglyceride measurement, body fat percentage, high density lipoprotein cholesterol measurement, sex hormone-binding globulin measurement	TRAF3 KCNU1 SPHKAP PKHD1 RERE	4.91e-04	364	53	5	EFO_0004612, EFO_0004696, EFO_0004735, EFO_0004736, EFO_0007800, EFO_0009946
Disease	body weight loss	SALL1 PKHD1	7.15e-04	22	53	2	EFO_0005245
Disease	brain connectivity measurement	MET SKIDA1 TRIOBP RERE SH3RF3	7.51e-04	400	53	5	EFO_0005210
Disease	vascular endothelial function measurement	ZNF28 ZNF761 ZNF468	7.60e-04	99	53	3	EFO_0803369
Disease	red blood cell density measurement	WWC2 POGLUT3 DENND4A SALL1 PKHD1 SIAH1 ITGA1	9.56e-04	880	53	7	EFO_0007978
Disease	C-reactive protein measurement	SALL1 KCND3 SPHKAP SLC5A6 RORC ZFPM1 ITGA1 RERE	1.31e-03	1206	53	8	EFO_0004458
Disease	basophil count	CSF2RA MARS1 TRIOBP ZFPM1 RERE	1.73e-03	483	53	5	EFO_0005090

Protein segments in the cluster

Peptide	Gene	Start	Entry
SCCVSSSPKLRRNAH	CCNY	6	Q8ND76
PSHLNNKSCRVTSLC	DCAF6	246	Q58WW2
SKCNIVCTQPRRISA	DHX29	621	Q7Z478
RLTPSQVKSTHNCDR	DENND4A	1831	Q7Z401
SKTQRRHCPACRLQK	NR1I3	56	Q14994
CCSRRSKKTTHLPNS	KCND3	546	Q9UK17
DPTQRVSCSCSRHKL	MED13L	416	Q71F56
CTRKNCNPLTITVHD	ERVS71-1	181	P61550
RPSSHKDLTQCVTCQ	LNX2	451	Q8N448
CQHRRTKNCSAAPTF	CALHM2	86	Q9HA72
SQKGTRCSHPRITQI	PLXNA3	831	P51805
HCVFTQRKITRPSQR	KIR3DL3	386	Q8N743
QCRKSCPSASSLEIH	ZFPM1	296	Q8IX07
ITNCGCKSRSRQHIT	KCNU1	616	A8MYU2
SLEPIKQTCCSSRQH	ITGA1	541	P56199
VKCTTVFRSHCIQPS	ALDH18A1	21	P54886
VKHLTSACPNVCRIS	PDSS1	61	Q5T2R2
SQKSPQARALCRSCS	FAM163B	81	P0C2L3
CHIPTRNASKACQTL	KRTAP24-1	131	Q3LI83
KCTFSLTHPANRSCR	SLC22A15	276	Q8IZD6
RSHTKERPFICTVCN	SALL1	1021	Q9NSC2
PSNVTVRCNTTHCLV	CSF2RA	221	P15509
CHTSRCTTVLDPLTN	OTOG	2711	Q6ZRI0
QHRSNSEIICCTTPS	MET	791	P08581
GRLTCPLCQHQTVLK	RNF207	56	Q6ZRF8
QACRKSDHLSVRPSC	SPHKAP	1166	Q2M3C7
SLLPLSCQKRLHCRS	SLC5A6	571	Q9Y289
REARKCLQTTPTTHC	SKIDA1	596	Q1XH10
KTPVRTTACQHVFCR	RNF138	26	Q8WVD3
PSLQHLCRLTINKCT	SOCS2	161	O14508
QSGHLVCSNCRPKLT	SIAH1	56	Q8IUQ4
AKRKRNCPTVTCTSH	PKHD1	3616	P08F94
KLVHNSQACCRSPTP	RERE	131	Q9P2R6
TKQKCAAQPHTVRRT	SRBD1	116	Q8N5C6
CCTQKENLRPSSPHR	TRIOBP	871	Q9H2D6
TAQRISCRPKTHISN	ZNF525	176	Q8N782
SCKITCPHNSRIATD	TECTA	2051	O75443
STAICQCHRKKPSRE	POGLUT3	491	Q7Z4H8
VVSCPHKCSVQTLLR	TRAF3	201	Q13114
TAQRISCRPKTHISN	ZNF761	176	Q86XN6
LRCSPVNSHLCLSRQ	WWC2	266	Q6AWC2
SCTRQQNCPIDRTSR	RORC	66	P51449
PFQCHICQRSFTRKT	RLF	1171	Q13129
TTAKVLPCQHTFCRR	SH3RF3	66	Q8TEJ3
ACCSHRRPVKTSTCQ	ZNRF4	281	Q8WWF5
SSQPRKRLVSVCDHC	TLNRD1	26	Q9H1K6
THIRCLNCRSTSQKV	USP38	596	Q8NB14
CLCVKTTSQVRPRHI	PF4	41	P02776
TSQRISCRPKTHISN	ZNF813	176	Q6ZN06
SQRISCRPKTHISNN	ZNF888	176	P0CJ79
TSQRICCRPKTHISN	ZNF28	176	P17035
NTTSSTDICRPHQIC	TNFRSF1B	171	P20333
GLITKTHRQLCRSPC	ZC3H12C	111	Q9C0D7
ASTTLHVNCSHCKRP	WDR24	711	Q96S15
DKNCSRSPIVTHCNV	SLC6A14	161	Q9UN76
TSQRICCRPKTHISN	ZNF468	176	Q5VIY5
KVCRSCPVVQSSQHL	MARS1	436	P56192
TRSAPKSNRCNFCHV	NAALADL2	111	Q58DX5
HIQVCTTTPCMLRNS	NDUFV2	131	P19404