Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionvoltage-gated calcium channel activity

CACNA1A TMC2 TRPA1 CATSPER3

1.51e-0546654GO:0005245
GeneOntologyMolecularFunctionmonoatomic cation channel activity

ATP5F1E CACNA1A TMC2 TRPA1 NALCN CATSPER3 ATP5F1EP2

1.23e-04343657GO:0005261
GeneOntologyMolecularFunctionP-type proton-exporting transporter activity

ATP5F1E ATP5F1EP2

4.62e-0410652GO:0008553
GeneOntologyMolecularFunctionmonoatomic ion channel activity

ATP5F1E CACNA1A TMC2 TRPA1 NALCN CATSPER3 ATP5F1EP2

7.14e-04459657GO:0005216
GeneOntologyMolecularFunctionATP-dependent activity

ATP5F1E DNAH10 MYH7B ATP8B1 ASCC3 DNAH14 ATP5F1EP2 CDK7

8.23e-04614658GO:0140657
GeneOntologyMolecularFunctioncalcium channel activity

CACNA1A TMC2 TRPA1 CATSPER3

8.30e-04129654GO:0005262
GeneOntologyMolecularFunctioncalcium ion transmembrane transporter activity

CACNA1A TMC2 TRPA1 CATSPER3

1.49e-03151654GO:0015085
GeneOntologyMolecularFunctionvoltage-gated monoatomic cation channel activity

CACNA1A TMC2 TRPA1 CATSPER3

1.52e-03152654GO:0022843
GeneOntologyMolecularFunctionminus-end-directed microtubule motor activity

DNAH10 DNAH14

1.54e-0318652GO:0008569
GeneOntologyMolecularFunctionproton-transporting ATP synthase activity, rotational mechanism

ATP5F1E ATP5F1EP2

1.54e-0318652GO:0046933
GeneOntologyMolecularFunctionchannel activity

ATP5F1E CACNA1A TMC2 TRPA1 NALCN CATSPER3 ATP5F1EP2

1.56e-03525657GO:0015267
GeneOntologyMolecularFunctionpassive transmembrane transporter activity

ATP5F1E CACNA1A TMC2 TRPA1 NALCN CATSPER3 ATP5F1EP2

1.57e-03526657GO:0022803
GeneOntologyMolecularFunctionvoltage-gated monoatomic ion channel activity

CACNA1A TMC2 TRPA1 CATSPER3

2.93e-03182654GO:0005244
GeneOntologyMolecularFunctionvoltage-gated channel activity

CACNA1A TMC2 TRPA1 CATSPER3

3.05e-03184654GO:0022832
GeneOntologyMolecularFunctionproton channel activity

ATP5F1E ATP5F1EP2

3.47e-0327652GO:0015252
GeneOntologyBiologicalProcessnegative regulation of lung goblet cell differentiation

FOXP4 FOXP1

1.01e-052662GO:1901250
GeneOntologyBiologicalProcessregulation of lung goblet cell differentiation

FOXP4 FOXP1

3.02e-053662GO:1901249
GeneOntologyCellularComponentproton-transporting ATP synthase complex, catalytic core F(1)

ATP5F1E ATP5F1EP2

1.33e-046632GO:0045261
GeneOntologyCellularComponentvoltage-gated calcium channel complex

CACNA1A EFCAB9 CATSPER3

3.61e-0446633GO:0005891
GeneOntologyCellularComponentcation channel complex

ATP5F1E CACNA1A EFCAB9 CATSPER3 ATP5F1EP2

7.11e-04235635GO:0034703
GeneOntologyCellularComponentCatSper complex

EFCAB9 CATSPER3

9.15e-0415632GO:0036128
GeneOntologyCellularComponentmonoatomic ion channel complex

ATP5F1E CACNA1A EFCAB9 NALCN CATSPER3 ATP5F1EP2

9.58e-04378636GO:0034702
GeneOntologyCellularComponenttransporter complex

ATP5F1E CACNA1A EFCAB9 NALCN CATSPER3 ATP8B1 ATP5F1EP2

1.30e-03550637GO:1990351
GeneOntologyCellularComponentcalcium channel complex

CACNA1A EFCAB9 CATSPER3

1.40e-0373633GO:0034704
GeneOntologyCellularComponentproton-transporting two-sector ATPase complex, catalytic domain

ATP5F1E ATP5F1EP2

1.48e-0319632GO:0033178
GeneOntologyCellularComponentstereocilium bundle

TMC2 TRPA1 ATP8B1

1.75e-0379633GO:0032421
GeneOntologyCellularComponentproton-transporting ATP synthase complex

ATP5F1E ATP5F1EP2

2.17e-0323632GO:0045259
DomainFOXP-CC

FOXP4 FOXP1

6.06e-054602PF16159
DomainFOXP-CC

FOXP4 FOXP1

6.06e-054602IPR032354
DomainDDT

BAZ1A BAZ2B

6.06e-054602PF02791
DomainDDT

BAZ1A BAZ2B

1.01e-045602SM00571
DomainWSD

BAZ1A BAZ2B

1.01e-045602PF15613
DomainDDT_dom

BAZ1A BAZ2B

1.01e-045602IPR018501
DomainWHIM2_dom

BAZ1A BAZ2B

1.01e-045602IPR028941
DomainDDT

BAZ1A BAZ2B

1.51e-046602PS50827
DomainIon_trans_dom

CACNA1A TRPA1 NALCN CATSPER3

4.93e-04114604IPR005821
DomainIon_trans

CACNA1A TRPA1 NALCN CATSPER3

4.93e-04114604PF00520
DomainDynein_heavy_chain_D4_dom

DNAH10 DNAH14

9.01e-0414602IPR024317
DomainDynein_HC_stalk

DNAH10 DNAH14

9.01e-0414602IPR024743
DomainMT

DNAH10 DNAH14

9.01e-0414602PF12777
DomainAAA_8

DNAH10 DNAH14

9.01e-0414602PF12780
DomainDHC_fam

DNAH10 DNAH14

1.04e-0315602IPR026983
DomainDynein_heavy_dom

DNAH10 DNAH14

1.04e-0315602IPR004273
DomainDynein_heavy

DNAH10 DNAH14

1.04e-0315602PF03028
DomainBromodomain_CS

BAZ1A BAZ2B

3.14e-0326602IPR018359
Pubmed

Foxp1 and Foxp4 Deletion Causes the Loss of Follicle Stem Cell Niche and Cyclic Hair Shedding by Inducing Inner Bulge Cell Apoptosis.

FOXP4 FOXP1

3.55e-06266235759955
Pubmed

Foxp4: a novel member of the Foxp subfamily of winged-helix genes co-expressed with Foxp1 and Foxp2 in pulmonary and gut tissues.

FOXP4 FOXP1

1.06e-05366214516685
Pubmed

Deletion of tumor necrosis factor-alpha receptor type 1 exacerbates insulin resistance and hepatic steatosis in aromatase knockout mice.

CYP19A1 TNFRSF1A

1.06e-05366220226875
Pubmed

Human-specific transcriptional regulation of CNS development genes by FOXP2.

FOXP4 FOXP1

1.06e-05366219907493
Pubmed

Cloning, characterization and mapping of the human ATP5E gene, identification of pseudogene ATP5EP1, and definition of the ATP5E motif.

ATP5F1E ATP5F1EP2

1.06e-05366210727396
Pubmed

Protein-Protein Interaction Among the FoxP Family Members and their Regulation of Two Target Genes, VLDLR and CNTNAP2 in the Zebra Finch Song System.

FOXP4 FOXP1

1.06e-05366228507505
Pubmed

Transcriptional regulation by FOXP1, FOXP2, and FOXP4 dimerization.

FOXP4 FOXP1

1.06e-05366225027557
Pubmed

The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells.

FOXP4 BAZ2B MAEA USP24 ASCC3 MRPS22

1.63e-0528266623667531
Pubmed

Transcriptional and DNA binding activity of the Foxp1/2/4 family is modulated by heterotypic and homotypic protein interactions.

FOXP4 FOXP1

2.12e-05466214701752
Pubmed

Epithelium-generated neuropeptide Y induces smooth muscle contraction to promote airway hyperresponsiveness.

FOXP4 FOXP1

2.12e-05466227088802
Pubmed

Identification and characterization of T reg-like cells in zebrafish.

FOXP4 FOXP1

2.12e-05466229066577
Pubmed

Transcriptional genomics associates FOX transcription factors with human heart failure.

FOXP4 FOXP1

3.53e-05566216952980
Pubmed

Non-coding RNA Neat1 and Abhd11os expressions are dysregulated in medium spiny neurons of Huntington disease model mice.

SMIM10L2A SMIM10L2B

3.53e-05566230391555
Pubmed

A novel family of bromodomain genes.

BAZ1A BAZ2B

3.53e-05566210662543
Pubmed

Human FOX gene family (Review).

FOXP4 FOXP1

3.53e-05566215492844
Pubmed

Generation of mice with a conditional Foxp2 null allele.

FOXP4 FOXP1

5.29e-05666217619227
Pubmed

Interrupted Glucagon Signaling Reveals Hepatic α Cell Axis and Role for L-Glutamine in α Cell Proliferation.

FOXP4 FOXP1

5.29e-05666228591638
Pubmed

Foxp1/2/4-NuRD interactions regulate gene expression and epithelial injury response in the lung via regulation of interleukin-6.

FOXP4 FOXP1

7.40e-05766220185820
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

TYK2 PLEKHH1 FOXP4 SGSM1 MAEA PTDSS1 SMURF1 FOXP1 ATP8B1 DNAH14 STEAP1

1.05e-041489661128611215
Pubmed

Forkhead Box Protein P1 Is Dispensable for Retina but Essential for Lens Development.

FOXP4 FOXP1

1.58e-041066228384713
Pubmed

Foxp1/2/4 regulate endochondral ossification as a suppresser complex.

FOXP4 FOXP1

1.93e-041166225527076
Pubmed

FAM105A/OTULINL Is a Pseudodeubiquitinase of the OTU-Class that Localizes to the ER Membrane.

NUP155 PRXL2A RER1 TBC1D22B HACD2 LCLAT1

2.64e-0446866631056421
Pubmed

Nuclear CDKs drive Smad transcriptional activation and turnover in BMP and TGF-beta pathways.

SMURF1 CDK7

2.73e-041366219914168
Pubmed

Multiple sclerosis susceptibility alleles in African Americans.

TYK2 TNFRSF1A

2.73e-041366219865102
Pubmed

Structure of a mammalian sperm cation channel complex.

EFCAB9 CATSPER3

2.73e-041366234225353
Pubmed

Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians.

PSMD6 MAEA

3.18e-041466222158537
Pubmed

Uncovering a mammalian neural-specific poly(A) binding protein with unique properties.

ATP5F1E ATP5F1EP2

3.67e-041566237704377
Pubmed

A new mouse model of ARX dup24 recapitulates the patients' behavioral and fine motor alterations.

CACNA1A FOXP1

4.18e-041666229659809
Pubmed

The FOXP1, FOXP2 and FOXP4 transcription factors are required for islet alpha cell proliferation and function in mice.

FOXP4 FOXP1

4.18e-041666226021489
Pubmed

Foxp-mediated suppression of N-cadherin regulates neuroepithelial character and progenitor maintenance in the CNS.

FOXP4 FOXP1

4.18e-041666222542185
Pubmed

Loss-of-Function Variants in TBC1D32 Underlie Syndromic Hypopituitarism.

DNAH10 BAZ1A MRPS22

5.01e-048166332060556
Pubmed

Coordinated metabolic responses to cyclophilin D deletion in the developing heart.

ATP5F1E ATP5F1EP2

5.32e-041866238414851
Pubmed

Genome-scale RNAi screen for host factors required for HIV replication.

LRRIQ1 NUP155 BAZ2B SMURF1 ARL9

6.23e-0436166518976975
Pubmed

Foxp1 and lhx1 coordinate motor neuron migration with axon trajectory choice by gating Reelin signalling.

FOXP1 CDH6

6.59e-042066220711475
Pubmed

Assembly of human mitochondrial ATP synthase through two separate intermediates, F1-c-ring and b-e-g complex.

ATP5F1E ATP5F1EP2

7.28e-042166226297831
Pubmed

RUNX1 maintains the identity of the fetal ovary through an interplay with FOXL2.

CYP19A1 FOXP1

7.28e-042166231712577
Pubmed

Foxp1 Regulates Neural Stem Cell Self-Renewal and Bias Toward Deep Layer Cortical Fates.

FOXP4 FOXP1

7.99e-042266232049024
Pubmed

Quantitative trait loci for body size components in mice.

FZD9 FOXP4 FOXP1

8.73e-049866316783635
Pubmed

Synergistic integration of Netrin and ephrin axon guidance signals by spinal motor neurons.

FOXP4 FOXP1

9.53e-042466226633881
Pubmed

Foxg1 confines Cajal-Retzius neuronogenesis and hippocampal morphogenesis to the dorsomedial pallium.

FZD9 CDH6

9.53e-042466215858069
Pubmed

Circular RNA FOXP1 promotes tumor progression and Warburg effect in gallbladder cancer by regulating PKLR expression.

BAZ2B MYH7B FOXP1

9.80e-0410266331623628
Pubmed

Foxp2 and Foxp1 cooperatively regulate lung and esophagus development.

FOXP4 FOXP1

1.03e-032566217428829
Pubmed

Zbtb20 modulates the sequential generation of neuronal layers in developing cortex.

FOXP1 CDH6

1.03e-032566227282384
Pubmed

Foxp transcription factors suppress a non-pulmonary gene expression program to permit proper lung development.

FOXP4 FOXP1

1.12e-032666227341756
Pubmed

Proteomic analysis of FOXP proteins reveals interactions between cortical transcription factors associated with neurodevelopmental disorders.

FOXP4 FOXP1

1.30e-032866229365100
Pubmed

Motor neuron position and topographic order imposed by β- and γ-catenin activities.

FOXP1 CDH6

1.39e-032966222036570
Pubmed

Expressed sequence tag analysis of human RPE/choroid for the NEIBank Project: over 6000 non-redundant transcripts, novel genes and splice variants.

EPHX2 SMIM10L2A DNAH14

1.45e-0311766312107410
Pubmed

TRAF4 promotes TGF-β receptor signaling and drives breast cancer metastasis.

SMURF1 MRPS22

1.49e-033066223973329
Pubmed

The G4 resolvase Dhx36 modulates cardiomyocyte differentiation and ventricular conduction system development.

PLEKHH1 MYH7B

1.49e-033066239366945
Pubmed

Spontaneous preterm birth in African Americans is associated with infection and inflammatory response gene variants.

EPHX2 CYP19A1 TNFRSF1A

1.76e-0312566319019335
Pubmed

Control of a neuronal morphology program by an RNA-binding zinc finger protein, Unkempt.

NUP155 RER1 FOXP1 ATP5F1EP2

1.78e-0327166425737280
Pubmed

Hox repertoires for motor neuron diversity and connectivity gated by a single accessory factor, FoxP1.

FOXP4 FOXP1

1.80e-033366218662545
Pubmed

Preterm birth in Caucasians is associated with coagulation and inflammation pathway gene variants.

EPHX2 CYP19A1 TNFRSF1A

1.88e-0312866318818748
Pubmed

Racial disparity in pathophysiologic pathways of preterm birth based on genetic variants.

EPHX2 CYP19A1 TNFRSF1A

1.88e-0312866319527514
Cytoband3p14.1

PSMD6 FOXP1

5.50e-04246623p14.1
Cytoband5q12.1

ELOVL7 CDK7

5.50e-04246625q12.1
GeneFamilyDyneins, axonemal

DNAH10 DNAH14

8.04e-0417452536
Diseasemitochondrial complex V (ATP synthase) deficiency nuclear type 3 (implicated_via_orthology)

ATP5F1E ATP5F1EP2

4.07e-062602DOID:0060332 (implicated_via_orthology)
Diseaselevel of Sterol ester (27:1/16:0) in blood serum

USP24 TTC22 TM6SF2

2.01e-0526603OBA_2045191
Diseasespecific developmental disorder (implicated_via_orthology)

FOXP4 FOXP1

2.43e-054602DOID:0060038 (implicated_via_orthology)
DiseaseCachexia

TNFRSF1A CDH6

2.65e-0412602C0006625
Diseaseprotein C measurement

FZD9 MYH7B

5.42e-0417602EFO_0004633
Diseaselevel of Sterol ester (27:1/20:3) in blood serum

USP24 TM6SF2

6.80e-0419602OBA_2045199
Diseaseesophagus adenocarcinoma (is_implicated_in)

CYP19A1 FOXP1

8.33e-0421602DOID:4914 (is_implicated_in)
Diseaseproprotein convertase subtilisin/kexin type 9 measurement

USP24 TM6SF2

9.15e-0422602EFO_0009312
Diseaselumbar disc degeneration

EYS MYH7B

1.49e-0328602EFO_0004994
Diseasedihydroxy docosatrienoic acid measurement

PSMD6 EYS

1.94e-0332602EFO_0005275

Protein segments in the cluster

PeptideGeneStartEntry
RFYIRRMVKTQAFYW

CACNA1A

476

O00555
FMALWTSYDIRYRLF

CATSPER3

66

Q86XQ3
RCFYWLMQRAGFPYR

ACTR8

316

Q9H981
MFGQDRYRRRYWILP

BAZ2B

1376

Q9UIF8
FRSYWEMYLSKGLLL

ARL9

76

Q6T311
WVLYEMPNYRGRQYL

CRYGA

131

P11844
MVAYWRQAGLSYIRY

ATP5F1E

1

P56381
MVAYWRQAGLSYIRY

ATP5F1EP2

1

Q5VTU8
RWSYIRMCKFLRYFF

ATP8B1

941

O43520
NIFPLGRDRMYRRYW

BAZ1A

801

Q9NRL2
LQQMYQYLLFDFRIW

NBEAL1

996

Q6ZS30
MFFKGRHLWRIYYDI

MMP27

296

Q9H306
QVWMYCRLYRTFERF

RENBP

71

P51606
ARWRMLIQQFRYDNY

MAEA

261

Q7L5Y9
RYLCFLRWAGNMYLE

EYS

551

Q5T1H1
FLWNCLMRYSYLRLE

LCLAT1

131

Q6UWP7
MRLKQGSFLWYLYLD

EFCAB9

1

A8MZ26
LRQRYARWMIYTYSG

MYH7B

146

A7E2Y1
IYNWFTRMFAYFRRN

FOXP1

491

Q9H334
QMIETYFDFRLYRLW

NSMF

501

Q6X4W1
NEIYNWFTRMFAYFR

FOXP4

491

Q8IVH2
VIQSYWRGYLMRRQT

LRRIQ1

1341

Q96JM4
DQNRVRYMDLLWRYY

NUP155

1071

O75694
YTLMDIAYIYPWRRN

PCGF2

206

P35227
YVYERLNMDFWRLRA

FZD9

466

O00144
VWYMALFYPERVRAV

EPHX2

341

P34913
MWNRYFVFYLLLLSA

COL28A1

1

Q2UY09
YYNRVYGEFMRVWIS

CYP19A1

76

P11511
LRMARTCWLYYFSKF

ELOVL7

111

A1L3X0
RWYRAPELLFGARMY

CDK7

176

P50613
WARYTLFIVLYPMGV

HACD2

166

Q6Y1H2
YTAIQRRYMRFVTVW

DNAH14

3281

Q0VDD8
MRTYRYFLLLFWVGQ

CDH6

1

P55285
MVYFLRRFSQYMLWV

DNAH10

4301

Q8IVF4
WLFAPHYRYYVREMR

PSMD6

286

Q15008
VFPMYRYFVTVWLRH

MROH2A

256

A6NES4
LLRSTRYFGGMVWYF

MRPS22

261

P82650
SFVYMIRVYLLQGWY

RER1

51

O15258
RRWFVLRGNMLFYFE

PHETA1

36

Q8N4B1
RRYEVEYLQFAFRWM

TBC1D22B

396

Q9NU19
QLRAQVWRYLTYIFM

RHBDL3

206

P58872
FTAWYRRMSVVYGIG

SMIM26

6

A0A096LP01
AWRLRMNFPYFYIVA

SMIM10L2A

51

P0DMW4
AWRLRMNFPYFYIVA

SMIM10L2B

51

P0DMW5
LRYFRIFIALWNIFM

SMIM7

51

Q9BQ49
MGFIRLGVWYNFFRA

PRXL2A

151

Q9BRX8
EYVRLYVNWRFMRGI

SMURF1

586

Q9HCE7
SYPMRRSYRYKLLNW

STEAP1

181

Q9UHE8
WISYTYLYVRMRANP

ASCC3

916

Q8N3C0
LDYITWTYFFRRLIM

ASCC3

1751

Q8N3C0
WTYFFRRLIMNPSYY

ASCC3

1756

Q8N3C0
QYRLRYVMVYTLWAA

NKAIN4

56

Q8IVV8
FYWMNFLLYLQRFEN

TRPA1

841

O75762
CRILLFPFMYWSYGR

TLCD3A

191

Q8TBR7
KRGYAMILWFLYIFV

TMEM121

71

Q9BTD3
LMTYFIQLGFAWIRF

RHPN2P1

86

A8MT19
NMKYQILSRAFYGWL

SGSM1

541

Q2NKQ1
KRRWFVLRQGQIMYY

PLEKHH1

596

Q9ULM0
DVRRRYWNAYMLFYQ

USP24

2026

Q9UPU5
RYRNFGLYWLGSFAM

TM6SF2

136

Q9BZW4
SYFIFLRWMYGVNLV

TMC2

251

Q8TDI7
RGWYFTMATLYIRLD

TTC22

196

Q5TAA0
SLLFIGLMYRYQRWK

TNFRSF1A

226

P19438
LIRETIYGRMWYFTS

TMLHE

211

Q9NVH6
WRMVFGLSVLYFLFL

PTDSS1

101

P48651
LYFRIRFYFRNWHGM

TYK2

101

P29597
WTMTYVFYRENLRRL

NLRP14

436

Q86W24
MYRAIDSFPRWRSYF

NALCN

286

Q8IZF0