Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionATP-dependent activity

MYO1G HSP90B1 MYO5A EIF4A3 SMC4 ABCB6 MSH3 KIF7 RAD50 ATP12A ABCD2 ATP4A HSPA9 TOP2A TOP2B SLC27A4 KIF2C

3.97e-0561417917GO:0140657
GeneOntologyMolecularFunctionstructural constituent of postsynaptic density

SHANK1 SHANK2 DLG3

1.11e-04111793GO:0098919
GeneOntologyMolecularFunctionstructural constituent of postsynaptic specialization

SHANK1 SHANK2 DLG3

1.90e-04131793GO:0098879
GeneOntologyMolecularFunctionP-type potassium:proton transporter activity

ATP12A ATP4A

2.38e-0431792GO:0008900
GeneOntologyMolecularFunctionphosphatidylinositol-3-phosphate phosphatase activity

MTMR1 MTMR14 FIG4

2.40e-04141793GO:0004438
GeneOntologyMolecularFunctionphosphatidylinositol monophosphate phosphatase activity

MTMR1 MTMR14 FIG4

2.98e-04151793GO:0052744
GeneOntologyMolecularFunctionphosphatidylinositol-3,5-bisphosphate phosphatase activity

MTMR1 MTMR14 FIG4

3.64e-04161793GO:0106018
GeneOntologyMolecularFunctionsynaptic receptor adaptor activity

SHANK1 SHANK2

4.74e-0441792GO:0030160
GeneOntologyMolecularFunctionDNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity

TOP2A TOP2B

4.74e-0441792GO:0003918
GeneOntologyBiologicalProcesssynaptic signaling

SHANK1 CLSTN3 ERBB4 MYO5A EIF4A3 LILRB2 NTNG1 ZZEF1 LRIT3 CHRNB2 PRR7 TBC1D24 SLC6A3 SLC6A6 CDKL5 RNF167 IGF1R NF1 PTPRD SHANK2 AKAP9 PRKAR2A DLG3 TNR LARGE1

9.88e-0797617725GO:0099536
GeneOntologyBiologicalProcessmodulation of chemical synaptic transmission

SHANK1 CLSTN3 ERBB4 MYO5A EIF4A3 LILRB2 NTNG1 ZZEF1 CHRNB2 TBC1D24 SLC6A6 CDKL5 RNF167 IGF1R NF1 PTPRD SHANK2 PRKAR2A TNR LARGE1

1.14e-0666317720GO:0050804
GeneOntologyBiologicalProcessregulation of trans-synaptic signaling

SHANK1 CLSTN3 ERBB4 MYO5A EIF4A3 LILRB2 NTNG1 ZZEF1 CHRNB2 TBC1D24 SLC6A6 CDKL5 RNF167 IGF1R NF1 PTPRD SHANK2 PRKAR2A TNR LARGE1

1.17e-0666417720GO:0099177
GeneOntologyBiologicalProcesssynapse organization

SHANK1 DOCK1 CLSTN3 ERBB4 PRMT8 MYO5A LILRB2 NTNG1 LRIT3 CHRNB2 CDKL5 IGF1R NF1 PTPRD SHANK2 PLXNC1 GPC4 TNR KIF2C LARGE1

1.88e-0668517720GO:0050808
GeneOntologyBiologicalProcessanterograde trans-synaptic signaling

SHANK1 CLSTN3 ERBB4 MYO5A EIF4A3 LILRB2 NTNG1 ZZEF1 CHRNB2 TBC1D24 SLC6A3 SLC6A6 CDKL5 RNF167 IGF1R NF1 PTPRD SHANK2 AKAP9 PRKAR2A DLG3 TNR LARGE1

5.09e-0693117723GO:0098916
GeneOntologyBiologicalProcesschemical synaptic transmission

SHANK1 CLSTN3 ERBB4 MYO5A EIF4A3 LILRB2 NTNG1 ZZEF1 CHRNB2 TBC1D24 SLC6A3 SLC6A6 CDKL5 RNF167 IGF1R NF1 PTPRD SHANK2 AKAP9 PRKAR2A DLG3 TNR LARGE1

5.09e-0693117723GO:0007268
GeneOntologyBiologicalProcesstrans-synaptic signaling

SHANK1 CLSTN3 ERBB4 MYO5A EIF4A3 LILRB2 NTNG1 ZZEF1 CHRNB2 TBC1D24 SLC6A3 SLC6A6 CDKL5 RNF167 IGF1R NF1 PTPRD SHANK2 AKAP9 PRKAR2A DLG3 TNR LARGE1

5.86e-0693917723GO:0099537
GeneOntologyBiologicalProcessassociative learning

SHANK1 EIF4A3 ZZEF1 CHRNB2 NF1 SHANK2 AP1S2 TNR

1.67e-051301778GO:0008306
GeneOntologyBiologicalProcessmelanosome assembly

ABCB6 HPS3 AP1S2 HPS5

1.84e-05191774GO:1903232
GeneOntologyBiologicalProcesscell junction organization

SHANK1 DOCK1 CLSTN3 ERBB4 PRMT8 MYO5A LILRB2 NTNG1 LRIT3 CHRNB2 CDKL5 IGF1R NF1 PTPRD SHANK2 PLXNC1 GPC4 MMP14 TNR TBCD KIF2C LARGE1

3.29e-0597417722GO:0034330
GeneOntologyBiologicalProcessdephosphorylation

HSP90B1 RNGTT LILRB2 MTMR1 SMG5 PTPRU PPP4R3B PTPRD DUSP29 NUAK1 MTMR14 FIG4

4.79e-0534717712GO:0016311
GeneOntologyBiologicalProcessplatelet dense granule organization

F2RL3 HPS3 AP1S2 HPS5

5.76e-05251774GO:0060155
GeneOntologyBiologicalProcessprotein localization to synapse

SHANK1 CLSTN3 ERBB4 VPS26B GPC4 OLFM2 KIF2C

6.12e-051151777GO:0035418
GeneOntologyBiologicalProcessneurotransmitter receptor localization to postsynaptic specialization membrane

ERBB4 VPS26B GPC4 OLFM2 KIF2C

6.18e-05491775GO:0099645
GeneOntologyBiologicalProcessprotein localization to postsynaptic specialization membrane

ERBB4 VPS26B GPC4 OLFM2 KIF2C

6.18e-05491775GO:0099633
GeneOntologyBiologicalProcesspositive regulation of single stranded viral RNA replication via double stranded DNA intermediate

TOP2A TOP2B

7.32e-0521772GO:0045870
GeneOntologyBiologicalProcesscognition

SHANK1 CLSTN3 WASHC4 EIF4A3 LILRB2 ZZEF1 CHRNB2 SLC6A3 NF1 SHANK2 AP1S2 TNR LARGE1

7.73e-0542317713GO:0050890
GeneOntologyBiologicalProcesslearning

SHANK1 CLSTN3 EIF4A3 ZZEF1 CHRNB2 NF1 SHANK2 AP1S2 TNR

9.31e-052121779GO:0007612
GeneOntologyBiologicalProcesspeptidyl-amino acid modification

CDC42BPG FLT1 ERBB4 PRMT8 EOGT EID3 DPY19L1 RET NSMCE3 ZZEF1 IFNA8 TBC1D24 IGF1R AKAP9 CSNK1D CSNK1E RPS6KA6 DLG3 PRKDC TAF1 PLK1

1.00e-0497617721GO:0018193
GeneOntologyBiologicalProcesspigmentation

MYO5A ABCB6 HPS3 NF1 FIG4 AP1S2 HPS5

1.04e-041251777GO:0043473
GeneOntologyBiologicalProcesssynaptic transmission, glutamatergic

CLSTN3 MYO5A ZZEF1 RNF167 NF1 SHANK2 TNR

1.46e-041321777GO:0035249
GeneOntologyBiologicalProcesscellular pigmentation

MYO5A ABCB6 HPS3 AP1S2 HPS5

2.23e-04641775GO:0033059
GeneOntologyBiologicalProcessreceptor localization to synapse

ERBB4 VPS26B GPC4 DLG3 OLFM2 KIF2C

2.37e-041011776GO:0097120
GeneOntologyBiologicalProcesscell morphogenesis involved in neuron differentiation

SHANK1 NTNG1 LAMC3 RET GDI1 CHRNB2 TBC1D24 CDKL5 IGF1R PTPRD PLXNC1 CCR5 TNR PLS1 TOP2B TBCD CLRN2

2.53e-0474817717GO:0048667
GeneOntologyBiologicalProcessprotein localization to cell junction

SHANK1 CLSTN3 ERBB4 VPS26B GPC4 OLFM2 KIF2C

2.95e-041481777GO:1902414
GeneOntologyBiologicalProcessregulation of protein localization to synapse

CLSTN3 VPS26B GPC4 KIF2C

3.08e-04381774GO:1902473
GeneOntologyBiologicalProcessmelanosome organization

ABCB6 HPS3 AP1S2 HPS5

3.41e-04391774GO:0032438
GeneOntologyBiologicalProcesspigment granule organization

ABCB6 HPS3 AP1S2 HPS5

3.76e-04401774GO:0048753
GeneOntologyBiologicalProcesslearning or memory

SHANK1 CLSTN3 EIF4A3 LILRB2 ZZEF1 CHRNB2 NF1 SHANK2 AP1S2 TNR LARGE1

3.93e-0437317711GO:0007611
GeneOntologyBiologicalProcessGDF15-GFRAL signaling pathway

RET MMP14

4.34e-0441772GO:0160144
GeneOntologyBiologicalProcesssynaptic vesicle budding from endosome

BTBD8 AP1S2

4.34e-0441772GO:0016182
GeneOntologyBiologicalProcessregulation of hematopoietic stem cell differentiation

PRKDC HSPA9 PUS7

4.61e-04181773GO:1902036
GeneOntologyCellularComponentglutamatergic synapse

SHANK1 DOCK1 CLSTN3 ERBB4 MYO5A VPS26B EIF4A3 NTNG1 PRR7 CDKL5 IGF1R NF1 PTPRD SHANK2 AKAP9 PLXNC1 GPC4 PRKAR2A DLG3 OLFM2 TNR KIF2C

2.05e-0681717922GO:0098978
GeneOntologyCellularComponentmembrane protein complex

MAGEL2 BTBD8 VPS26B LILRB2 BEST3 ABCB6 RET NDUFS3 CHRNB2 RYR2 SLC6A3 SLC6A6 KCNH6 IGF1R TRPM5 AKAP9 KCNH2 AP5B1 AP1S2 DLG3 OLFM2 OSMR AP4B1 ATP12A NCF1C NCF1B ATP4A HSPA9

7.59e-05149817928GO:0098796
GeneOntologyCellularComponentpotassium:proton exchanging ATPase complex

ATP12A ATP4A

2.18e-0431792GO:0005889
GeneOntologyCellularComponentBLOC-2 complex

HPS3 HPS5

2.18e-0431792GO:0031084
GeneOntologyCellularComponentplasma membrane protein complex

BTBD8 LILRB2 ABCB6 RET CHRNB2 SLC6A3 SLC6A6 IGF1R AKAP9 KCNH2 DLG3 OLFM2 OSMR ATP12A NCF1C NCF1B ATP4A

4.31e-0478517917GO:0098797
GeneOntologyCellularComponentsynaptic membrane

SHANK1 CLSTN3 ERBB4 NTNG1 CHRNB2 PRR7 SLC6A3 SLC6A6 PTPRD SHANK2 AKAP9 GPC4 DLG3 OLFM2

5.15e-0458317914GO:0097060
GeneOntologyCellularComponenttransmembrane transporter complex

BEST3 ABCB6 NDUFS3 CHRNB2 RYR2 KCNH6 TRPM5 AKAP9 KCNH2 DLG3 OLFM2 ATP12A ATP4A

5.93e-0452317913GO:1902495
GeneOntologyCellularComponentAP-type membrane coat adaptor complex

BTBD8 AP5B1 AP1S2 AP4B1

7.54e-04481794GO:0030119
GeneOntologyCellularComponentpostsynaptic membrane

SHANK1 CLSTN3 ERBB4 CHRNB2 PRR7 SLC6A3 SLC6A6 SHANK2 AKAP9 DLG3 OLFM2

7.65e-0440517911GO:0045211
GeneOntologyCellularComponentsomatodendritic compartment

SHANK1 CLSTN3 ERBB4 MYO5A EIF4A3 RET GDI1 LRIT3 PRR7 SLC6A3 SLC6A6 CDKL5 IGF1R TRPM5 NF1 SHANK2 AKAP9 CSNK1E DLG3 NCF1C NCF1B CKMT1A

8.40e-04122817922GO:0036477
GeneOntologyCellularComponentneuronal cell body

ERBB4 MYO5A EIF4A3 RET GDI1 LRIT3 SLC6A3 SLC6A6 IGF1R TRPM5 SHANK2 AKAP9 CSNK1E DLG3 NCF1C NCF1B CKMT1A

8.59e-0483517917GO:0043025
GeneOntologyCellularComponenttransporter complex

BEST3 ABCB6 NDUFS3 CHRNB2 RYR2 KCNH6 TRPM5 AKAP9 KCNH2 DLG3 OLFM2 ATP12A ATP4A

9.42e-0455017913GO:1990351
GeneOntologyCellularComponentBLOC complex

WASHC4 HPS3 HPS5

9.64e-04231793GO:0031082
GeneOntologyCellularComponentchromosomal region

FLYWCH1 EID3 SMC4 TFIP11 NSMCE3 RAD50 FBXO28 PRKDC PLK1 TOP2A KIF2C

1.05e-0342117911GO:0098687
GeneOntologyCellularComponentdendrite

SHANK1 CLSTN3 ERBB4 MYO5A EIF4A3 RET LRIT3 PRR7 SLC6A6 CDKL5 TRPM5 NF1 SHANK2 AKAP9 DLG3 NCF1C NCF1B

1.15e-0385817917GO:0030425
GeneOntologyCellularComponentdendritic tree

SHANK1 CLSTN3 ERBB4 MYO5A EIF4A3 RET LRIT3 PRR7 SLC6A6 CDKL5 TRPM5 NF1 SHANK2 AKAP9 DLG3 NCF1C NCF1B

1.18e-0386017917GO:0097447
GeneOntologyCellularComponentpostsynapse

SHANK1 DOCK1 CLSTN3 ERBB4 MYO5A VPS26B EIF4A3 ZZEF1 CHRNB2 PRR7 SLC6A3 SLC6A6 CDKL5 IGF1R SHANK2 AKAP9 DLG3 OLFM2 KIF2C

1.20e-03101817919GO:0098794
GeneOntologyCellularComponentpostsynaptic specialization membrane

CLSTN3 ERBB4 CHRNB2 PRR7 AKAP9 DLG3 OLFM2

1.77e-032011797GO:0099634
GeneOntologyCellularComponentneuron to neuron synapse

SHANK1 CLSTN3 ERBB4 PRR7 CDKL5 PTPRD SHANK2 AKAP9 PLXNC1 DLG3 OLFM2 TNR

1.89e-0352317912GO:0098984
GeneOntologyCellularComponentclathrin adaptor complex

BTBD8 AP1S2 AP4B1

2.33e-03311793GO:0030131
GeneOntologyCellularComponentpostsynaptic density membrane

CLSTN3 ERBB4 PRR7 AKAP9 DLG3 OLFM2

2.36e-031571796GO:0098839
GeneOntologyCellularComponentSmc5-Smc6 complex

EID3 NSMCE3

2.52e-0391792GO:0030915
GeneOntologyCellularComponentsarcoplasmic reticulum lumen

HSP90B1 MANF

2.52e-0391792GO:0033018
GeneOntologyCellularComponentcell body

ERBB4 MYO5A EIF4A3 RET GDI1 LRIT3 SLC6A3 SLC6A6 IGF1R TRPM5 SHANK2 AKAP9 CSNK1E DLG3 NCF1C NCF1B CKMT1A

2.67e-0392917917GO:0044297
GeneOntologyCellularComponentactin-based cell projection

MYO1G MYO5A PKHD1L1 SLC6A6 LOXHD1 PLS1 SLC27A4 CLRN2

2.79e-032781798GO:0098858
GeneOntologyCellularComponentmelanosome

HSP90B1 MYO5A ABCB6 FASN MMP14

2.90e-031131795GO:0042470
GeneOntologyCellularComponentpigment granule

HSP90B1 MYO5A ABCB6 FASN MMP14

2.90e-031131795GO:0048770
GeneOntologyCellularComponentstereocilium

PKHD1L1 LOXHD1 PLS1 CLRN2

2.91e-03691794GO:0032420
MousePhenoabnormal spatial learning

SHANK1 ARSG CHRNB2 SLC6A3 NF1 PTPRD SHANK2 AP1S2 DLG3 CCR5 NCF1C NCF1B CKMT1A

6.88e-0627614713MP:0001463
DomainTyr_Pase_AS

RNGTT MTMR1 PTPRU PTPRD DUSP29 MTMR14

6.09e-05731746IPR016130
Domain-

TOP2A TOP2B

8.63e-05217423.40.50.670
DomainDTHCT

TOP2A TOP2B

8.63e-0521742IPR012542
DomainDNA_gyraseB

TOP2A TOP2B

8.63e-0521742PF00204
Domain-

TOP2A TOP2B

8.63e-05217423.90.199.10
DomainTopoIIA_CS

TOP2A TOP2B

8.63e-0521742IPR018522
DomainTopo_IIA

TOP2A TOP2B

8.63e-0521742IPR001241
DomainDNA_topoisoIV

TOP2A TOP2B

8.63e-0521742PF00521
DomainTopo_IIA_A/C_ab

TOP2A TOP2B

8.63e-0521742IPR013758
DomainTopo_IIA_A_a

TOP2A TOP2B

8.63e-0521742IPR013757
DomainTopo_IIA_cen_dom

TOP2A TOP2B

8.63e-0521742IPR013759
DomainTOP4c

TOP2A TOP2B

8.63e-0521742SM00434
DomainTOP2c

TOP2A TOP2B

8.63e-0521742SM00433
DomainTopo_IIA-like_dom

TOP2A TOP2B

8.63e-0521742IPR013760
DomainTopo_IIA_bsu_dom2

TOP2A TOP2B

8.63e-0521742IPR013506
DomainDTHCT

TOP2A TOP2B

8.63e-0521742PF08070
Domain-

TOP2A TOP2B

8.63e-05217421.10.268.10
DomainTOPRIM_C

TOP2A TOP2B

8.63e-0521742IPR031660
DomainTOPRIM_C

TOP2A TOP2B

8.63e-0521742PF16898
DomainTopo_IIA_A/C

TOP2A TOP2B

8.63e-0521742IPR002205
DomainTOPOISOMERASE_II

TOP2A TOP2B

8.63e-0521742PS00177
Domain-

RNGTT MTMR1 PTPRU PTPRD DUSP29 MTMR14

2.21e-049217463.90.190.10
DomainProtein_kinase_ATP_BS

CDC42BPG FLT1 ERBB4 RET CDKL5 IGF1R NUAK1 CSNK1D CSNK1E RPS6KA6 PLK1 SBK2

2.35e-0437917412IPR017441
DomainArg_repress_C-like

TOP2A TOP2B

2.57e-0431742IPR024946
Domain-

TOP2A TOP2B

2.57e-04317423.30.1360.40
DomainK_chnl_volt-dep_ERG

KCNH6 KCNH2

2.57e-0431742IPR003967
DomainRibosomal_S5_D2-typ_fold

HSP90B1 GFM1 TOP2A TOP2B

2.71e-04341744IPR020568
DomainProt-tyrosine_phosphatase-like

RNGTT MTMR1 PTPRU PTPRD DUSP29 MTMR14

3.28e-04991746IPR029021
DomainToprim

TOP2A TOP2B

5.11e-0441742PF01751
DomainToprim_domain

TOP2A TOP2B

5.11e-0441742IPR006171
DomainTOPRIM

TOP2A TOP2B

5.11e-0441742PS50880
DomainHATPase_c

HSP90B1 TOP2A TOP2B

5.85e-04181743SM00387
DomainHATPase_c

HSP90B1 TOP2A TOP2B

6.90e-04191743PF02518
Domain-

HSP90B1 TOP2A TOP2B

8.06e-042017433.30.565.10
Domain-

GFM1 TOP2A TOP2B

9.34e-042117433.30.230.10
DomainHATPase_C

HSP90B1 TOP2A TOP2B

9.34e-04211743IPR003594
DomainRibosomal_S5_D2-typ_fold_subgr

GFM1 TOP2A TOP2B

1.07e-03221743IPR014721
DomainTYR_PHOSPHATASE_1

RNGTT MTMR1 PTPRU PTPRD DUSP29

1.26e-03861745PS00383
DomainP-type_ATPase_IIC

ATP12A ATP4A

1.26e-0361742IPR005775
DomainPROTEIN_KINASE_ATP

CDC42BPG FLT1 ERBB4 RET CDKL5 IGF1R NUAK1 CSNK1D CSNK1E RPS6KA6 PLK1 SBK2

1.27e-0345917412PS00107
DomainTYR_PHOSPHATASE_dom

RNGTT MTMR1 PTPRU PTPRD DUSP29

1.32e-03871745IPR000387
DomainTYR_PHOSPHATASE_2

RNGTT MTMR1 PTPRU PTPRD DUSP29

1.32e-03871745PS50056
DomainKinase-like_dom

CDC42BPG FLT1 ERBB4 RET CDKL5 IGF1R NUAK1 CSNK1D CSNK1E RPS6KA6 PRKDC PLK1 SBK2

1.74e-0354217413IPR011009
DomainRecep_L_domain

ERBB4 IGF1R

1.76e-0371742PF01030
DomainFurin-like

ERBB4 IGF1R

1.76e-0371742PF00757
DomainRcpt_L-dom

ERBB4 IGF1R

1.76e-0371742IPR000494
DomainFurin-like_Cys-rich_dom

ERBB4 IGF1R

1.76e-0371742IPR006211
Domain-

ERBB4 IGF1R

1.76e-03717423.80.20.20
Pubmed

A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.

TMEM186 SRSF1 RNGTT BZW2 VPS26B SMC4 MTMR1 PTPRU KIF7 RAD50 FASN FAM120A PTPRD DUSP29 MTMR14 CSNK1D CSNK1E LTN1 PRKDC MMP14 PLK1 GFM1 PLS1 PUS7 MAN1B1 SLC27A4 KIF2C

1.96e-129741832728675297
Pubmed

Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.

HSP90B1 SRSF1 WASHC4 MYO5A EIF4A3 SMC4 TFIP11 MSH3 CMAS MTPAP NDUFS3 RAD50 FASN NF1 FAM120A LTN1 BYSL PRKDC MMP14 PLK1 SRSF9 HSPA9 TOP2A TOP2B SLC27A4 KIF2C

1.26e-0813531832629467282
Pubmed

Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.

CDC42BPG HSP90B1 SRSF1 SRSF2 EIF4A3 SMC4 TFIP11 CMAS GDI1 MTPAP NDUFS3 FASN IGF1R FAM120A AKAP9 CSNK1D CSNK1E BUD31 PRKAR2A PRKDC PFDN6 SRSF9 HSPA9 TOP2A

4.69e-0812471832427684187
Pubmed

A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome.

HSP90B1 ERBB4 SRSF2 CCDC146 MTMR1 RET PTPRU IGF1R NF1 SHANK2 DUSP29 MTMR14 HSPA9 CKMT1A

5.79e-084201831428065597
Pubmed

Centrosomal anchoring of the protein kinase CK1delta mediated by attachment to the large, coiled-coil scaffolding protein CG-NAP/AKAP450.

AKAP9 CSNK1D CSNK1E

1.43e-073183312270714
Pubmed

MYC multimers shield stalled replication forks from RNA polymerase.

HSP90B1 SRSF1 SRSF2 EIF4A3 TFIP11 CMAS RAD50 FASN UTP25 NFIC BYSL PRKDC PLK1 GFM1 SRSF9 HSPA9 TOP2A TOP2B SLC27A4 KIF2C

3.11e-079891832036424410
Pubmed

A rational nomenclature for serine/arginine-rich protein splicing factors (SR proteins).

SRSF1 SRSF2 SRSF8 SRSF9

5.11e-0713183420516191
Pubmed

Identification and developmental analysis of genes expressed by dopaminergic neurons of the substantia nigra pars compacta.

SHANK1 ERBB4 MYO5A RUNDC3A AKAP9 CSNK1D PLK1

5.15e-0790183715033168
Pubmed

Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.

DOCK1 HSP90B1 SRSF1 SRSF2 EIF4A3 SMC4 KTI12 RAD50 FASN NF1 PRKDC DEPDC7 PLK1 TOP2A KIF2C

5.25e-075821831520467437
Pubmed

Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.

HSP90B1 SRSF1 SRSF2 EIF4A3 CARS1 SMC4 LAMC3 MSH3 NDUFS3 RAD50 FASN NF1 FAM120A CSNK1E BYSL PRKAR2A PRKDC GFM1 SRSF9 HSPA9 TOP2A TOP2B SLC27A4 CKMT1A

5.31e-0714251832430948266
Pubmed

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.

SHANK1 HSP90B1 SRSF1 SRSF2 BTBD8 MYO5A MTMR1 CMAS GDI1 CCDC177 NDUFS3 TBC1D24 CDKL5 FASN NF1 FAM120A TTC7B SHANK2 CSNK1D PRKAR2A DLG3 TNR HSPA9 CKMT1A

5.72e-0714311832437142655
Pubmed

In silico APC/C substrate discovery reveals cell cycle-dependent degradation of UHRF1 and other chromatin regulators.

SRSF1 RNGTT BZW2 F2RL3 EIF4A3 UBE2C MRPL27 SMC4 NDUFS3 SLC6A6 FASN FAM120A CSNK1D BYSL PLK1 PFDN6 SRSF9 HSPA9 CKMT1A

1.02e-069711831933306668
Pubmed

Defining the membrane proteome of NK cells.

MYO1G HSP90B1 MYO5A DPY19L1 BZW2 EIF4A3 ALG11 MSH3 CMAS RAD50 FASN NF1 FAM120A PLXNC1 BYSL PRKAR2A PRKDC MAN1B1 SLC27A4 KIF2C PSD4

1.04e-0611681832119946888
Pubmed

Impaired OTUD7A-dependent Ankyrin regulation mediates neuronal dysfunction in mouse and human models of the 15q13.3 microdeletion syndrome.

SHANK1 ERBB4 MTMR1 PRR7 SLC6A6 CDKL5 SHANK2 PLXNC1 DLG3

1.11e-06197183936604605
Pubmed

KAP1 facilitates reinstatement of heterochromatin after DNA replication.

WASHC4 VPS26B EIF4A3 SMC4 MSH3 CMAS MTPAP NDUFS3 RAD50 FASN LTN1 AP1S2 PRKDC PLK1 TOP2A TOP2B

1.13e-067041831629955894
Pubmed

A differentially expressed murine RNA encoding a protein with similarities to two types of nucleic acid binding motifs.

SRSF1 SRSF2 SRSF9

1.42e-06518332030943
Pubmed

Phosphorylation of human enhancer filamentation 1 (HEF1) stimulates interaction with Polo-like kinase 1 leading to HEF1 localization to focal adhesions.

CSNK1D CSNK1E PLK1

1.42e-065183329191835
Pubmed

Superoxide production by macrophages and T cells is critical for the induction of autoreactivity and type 1 diabetes.

PRKDC NCF1C NCF1B

1.42e-065183321715554
Pubmed

Identification of proteins interacting with the rat somatostatin receptor subtype 2.

SHANK1 SHANK2 DLG3

1.42e-065183311087996
Pubmed

Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers.

EIF4A3 ADAM9 CARS1 PTPRU KCNH6 GCNT7 IGF1R CSNK1D KCNH2 CSNK1E RPS6KA6 PRKAR2A TAF1 MMP14 PLK1 ATP4A

1.81e-067301831634857952
Pubmed

Melanoregulin, product of the dsu locus, links the BLOC-pathway and OA1 in organelle biogenesis.

MYO5A HPS3 HPS5

2.83e-066183322984402
Pubmed

Identification of a novel Wnt5a-CK1ɛ-Dvl2-Plk1-mediated primary cilia disassembly pathway.

CSNK1D CSNK1E PLK1

2.83e-066183322609948
Pubmed

Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.

FLYWCH1 MRPL27 SMC4 MTMR1 BEND4 SMG5 MSH3 MTPAP KIF7 RAD50 TRAPPC13 FASN FAM120A NFIC TOP2A TOP2B KIF2C

3.25e-068571831725609649
Pubmed

Systematic analysis of human protein complexes identifies chromosome segregation proteins.

SRSF1 SRSF2 WASHC4 EIF4A3 UBE2C TFIP11 NSMCE3 MTPAP FASN SH2D4A FAM120A CSNK1E FBXO28 PRKAR2A PRKDC PLK1 PFDN6 TOP2A TOP2B TBCD

3.35e-0611551832020360068
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

SHANK1 SRSF1 MYO5A ADAM9 GDI1 CCDC177 KIF7 RAD50 NF1 FAM120A PTPRD SHANK2 AKAP9 PRKAR2A DLG3 TNR HSPA9 KIF2C

3.77e-069631831828671696
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

SHANK1 HSP90B1 CLSTN3 WASHC4 MYO5A EIF4A3 ADAM9 MAGEH1 USP25 TFIP11 SMG5 MSH3 CMAS GDI1 PPP4R3B FAM120A PTPRD TTC7B PRKDC TAF1 HSPA9

4.60e-0612851832135914814
Pubmed

Protein tyrosine phosphatase receptor delta acts as a neuroblastoma tumor suppressor by destabilizing the aurora kinase A oncogene.

PTPRD CSNK1D CSNK1E PLK1

5.04e-0622183422305495
Pubmed

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.

SRSF1 SRSF2 MYO5A EIF4A3 MRPL27 MTPAP FASN FAM120A CSNK1E SRSF8 RARS2 PRKDC SRSF9 HSPA9 TOP2A PUS7

6.44e-068071831622681889
Pubmed

PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.

RNGTT BZW2 EIF4A3 NAB2 SMC4 RAD50 PPP4R3B FASN FAM120A NFIC BUD31 CPNE1 PRKDC PLK1 PFDN6 HSPA9 TOP2A TOP2B KIF2C

6.44e-0611031831934189442
Pubmed

New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules.

SHANK1 DOCK1 PRMT8 SRSF1 SRSF2 EIF4A3 SMG5 RYR2 FAM120A NFIC RARS2 PLK1

6.90e-064621831231138677
Pubmed

Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity.

WASHC4 DPY19L1 F2RL3 RET CMAS RAD50 RUNDC3A IGF1R NF1 AKAP9 UTP25 NUAK1 CSNK1D CSNK1E PRKAR2A PLK1 HSPA9

7.14e-069101831736736316
Pubmed

Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.

EIF4A3 UBE2C SMC4 MSH3 NSMCE3 CMAS CCNC RAD50 PPP4R3B FASN NFIC CPNE1 PRKDC TAF1 SRSF9 TOP2A TOP2B PUS7

7.62e-0610141831832416067
Pubmed

The G protein-coupled receptor CL1 interacts directly with proteins of the Shank family.

SHANK1 SHANK2 DLG3

7.87e-068183310958799
Pubmed

Nuclear localization of Beclin 1 promotes radiation-induced DNA damage repair independent of autophagy.

RAD50 PRKDC TOP2B

7.87e-068183328345663
Pubmed

Arginine methylation and ubiquitylation crosstalk controls DNA end-resection and homologous recombination repair.

HSP90B1 PRMT8 EIF4A3 SMC4 RAD50 FASN FAM120A MTMR14 CSNK1E BYSL PRKDC HSPA9 KIF2C

7.97e-065511831334728620
Pubmed

Cell cycle-dependent phosphorylation regulates RECQL4 pathway choice and ubiquitination in DNA double-strand break repair.

HSP90B1 SRSF1 RNGTT WASHC4 EIF4A3 MRPL27 NSMCE3 GDI1 NDUFS3 RAD50 FASN FAM120A CSNK1D BYSL PRKAR2A PRKDC PLK1 SRSF9 PLS1 HSPA9 CKMT1A

8.21e-0613351832129229926
Pubmed

Comparative analysis of 1196 orthologous mouse and human full-length mRNA and protein sequences.

RET NF1 NCF1C NCF1B

8.61e-062518348889551
Pubmed

Identification of genes contributing to the obese yellow Avy phenotype: caloric restriction, genotype, diet x genotype interactions.

HSP90B1 SRSF1 GDI1 HPS3 FASN

8.93e-0653183515306695
Pubmed

Defining the Protein-Protein Interaction Network of the Human Protein Tyrosine Phosphatase Family.

EOGT RNGTT BZW2 MTMR1 PGAP4 NDUFS3 RAD50 MTMR14 LTN1 BYSL PRKAR2A PLK1 GFM1 PFDN6 SRSF9 MAN1B1 SLC27A4

9.60e-069311831727432908
Pubmed

Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.

HSP90B1 SRSF1 MYO5A EIF4A3 SMC4 CMAS GDI1 MTPAP RAD50 FASN FAM120A CSNK1D CSNK1E BYSL PRKDC SRSF9 ATP4A HSPA9 TOP2A KIF2C

1.16e-0512571832036526897
Pubmed

The SR protein family.

SRSF1 SRSF2 SRSF9

1.18e-059183319857271
Pubmed

Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.

HSP90B1 RNGTT MYO5A BZW2 MTMR1 PTPRU CCDC61 KIF7 PPP4R3B SH2D4A PTPRD TTC7B AKAP9 DUSP29 MTMR14 LTN1 PLK1 PFDN6

1.20e-0510491831827880917
Pubmed

Directed proteomic analysis of the human nucleolus.

SRSF1 SRSF2 RAD50 PRKDC SRSF9 HSPA9 TOP2A TOP2B

1.56e-05208183811790298
Pubmed

Large-scale mapping of human protein-protein interactions by mass spectrometry.

SRSF1 SRSF2 BZW2 SMC4 ALG11 GDI1 RAD50 PPP4R3B RNF167 IGF1R LOXHD1 SH2D4A NUAK1 CSNK1D CSNK1E DLG3 RARS2 AP4B1 PFDN6 SLC27A4

1.57e-0512841832017353931
Pubmed

H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.

SRSF1 SRSF2 FLYWCH1 EIF4A3 TFIP11 MSH3 CMAS RAD50 NFIC SRSF8 FBXO28 BUD31 TADA2A PRKDC SRSF9 HSPA9 TOP2A TOP2B SLC27A4 KIF2C

1.76e-0512941832030804502
Pubmed

Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.

SHANK1 PRMT8 MYO5A ADAM9 NF1 SHANK2 PRKAR2A DLG3 TNR

1.97e-05281183928706196
Pubmed

Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS.

BZW2 NDUFS3 FASN AKAP9 CSNK1D CSNK1E FBXO28 GPC4 PRKAR2A PRKDC HSPA9

2.01e-054321831123455922
Pubmed

TRIM29 regulates the assembly of DNA repair proteins into damaged chromatin.

SMC4 MSH3 RAD50 PRKDC

2.09e-0531183426095369
Pubmed

Embryonic forebrain transcriptome of mice with polyalanine expansion mutations in the ARX homeobox gene.

ERBB4 RAPGEF5 CDKL5 TNR

2.09e-0531183427798109
Pubmed

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.

HSP90B1 CLSTN3 EOGT DPY19L1 BZW2 ADAM9 ALG11 PGAP4 LAMC3 ZZEF1 SLC6A6 IGF1R NF1 FBXO28 LTN1 MANF OSMR MAN1B1 KIF2C

2.10e-0512011831935696571
Pubmed

The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.

SHANK1 HSP90B1 WASHC4 FLYWCH1 DPY19L1 ADAM9 MRPL27 TFIP11 MTPAP TBC1D24 PPP4R3B FASN IGF1R PRKDC HSPA9 TOP2A TOP2B SLC27A4 TBCD

2.15e-0512031831929180619
Pubmed

Direct binding of CoREST1 to SUMO-2/3 contributes to gene-specific repression by the LSD1/CoREST1/HDAC complex.

CARS1 RAD50 PRKDC HSPA9 TOP2A TOP2B

2.16e-05106183619394292
Pubmed

BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.

HSP90B1 SRSF1 SRSF2 EIF4A3 SMC4 TFIP11 MTPAP NDUFS3 PPP4R3B FASN FAM120A SRSF8 BUD31 PRKDC PLK1 SRSF9 HSPA9 TOP2A TOP2B KIF2C

2.28e-0513181832030463901
Pubmed

Conditional mutation of Smc5 in mouse embryonic stem cells perturbs condensin localization and mitotic progression.

SMC4 PLK1 TOP2A

2.29e-0511183326919979
Pubmed

Targeted and Interactome Proteomics Revealed the Role of PHD2 in Regulating BRD4 Proline Hydroxylation.

HSP90B1 SRSF1 SRSF2 EIF4A3 SMC4 RAD50 FASN PRKDC SRSF9 HSPA9 TOP2A

2.43e-054411831131239290
Pubmed

Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells.

HSP90B1 SRSF1 EIF4A3 SMC4 CMAS HEPH RAD50 FASN IGF1R RNASET2 PRKDC PLK1 HSPA9

2.44e-056131831322268729
Pubmed

Ubiquitin-assisted phase separation of dishevelled-2 promotes Wnt signalling.

SMC4 SH2D4A CSNK1D CSNK1E DLG3 PLK1 KIF2C

2.45e-05161183736398662
Pubmed

EZH2 interacts with HP1BP3 to epigenetically activate WNT7B that promotes temozolomide resistance in glioblastoma.

HSP90B1 SRSF1 SRSF2 MYO5A EIF4A3 SMC4 GDI1 FASN NF1 FAM120A GPC4 PRKDC SRSF9 HSPA9 TOP2A

2.52e-058031831536517590
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

WASHC4 FLYWCH1 EIF4A3 DOLK SMG5 ZZEF1 HEPH TBC1D24 PPP4R3B NUAK1 CPNE1 HPS5

2.63e-055291831214621295
Pubmed

Wnt regulation: exploring Axin-Disheveled interactions and defining mechanisms by which the SCF E3 ubiquitin ligase is recruited to the destruction complex.

HSP90B1 SRSF1 SRSF2 EIF4A3 SMC4 FASN FAM120A BYSL PRKAR2A PRKDC PLK1 SRSF9 HSPA9 CKMT1A KIF2C

2.75e-058091831532129710
Pubmed

DNA topoisomerase II is dispensable for oocyte meiotic resumption but is essential for meiotic chromosome condensation and separation in mice.

TOP2A TOP2B

2.75e-052183224048577
Pubmed

The activity regulation of the mitotic centromere-associated kinesin by Polo-like kinase 1.

PLK1 KIF2C

2.75e-052183225504441
Pubmed

Use of divalent metal ions in the dna cleavage reaction of human type II topoisomerases.

TOP2A TOP2B

2.75e-052183219222228
Pubmed

Characterization of cDNA encoding the mouse DNA topoisomerase II that can complement the budding yeast top2 mutation.

TOP2A TOP2B

2.75e-05218321331984
Pubmed

Mineralocorticoids stimulate the activity and expression of renal H+,K+-ATPases.

ATP12A ATP4A

2.75e-052183221164026
Pubmed

Protein-protein interactions and 5'-splice-site recognition in mammalian mRNA precursors.

SRSF1 SRSF2

2.75e-05218328139654
Pubmed

Regulation of casein kinase I epsilon and casein kinase I delta by an in vivo futile phosphorylation cycle.

CSNK1D CSNK1E

2.75e-05218329632646
Pubmed

Different patterns of gene expression of topoisomerase II isoforms in differentiated tissues during murine development.

TOP2A TOP2B

2.75e-05218321380833
Pubmed

Growth hormone deficiency and splicing fidelity: two serine/arginine-rich proteins, ASF/SF2 and SC35, act antagonistically.

SRSF1 SRSF2

2.75e-052183218586677
Pubmed

Impaired acid secretion in cortical collecting duct intercalated cells from H-K-ATPase-deficient mice: role of HKalpha isoforms.

ATP12A ATP4A

2.75e-052183218057185
Pubmed

Elevated TOP2A and UBE2C expressions correlate with poor prognosis in patients with surgically resected lung adenocarcinoma: a study based on immunohistochemical analysis and bioinformatics.

UBE2C TOP2A

2.75e-052183232103339
Pubmed

Dephosphorylation-dependent sorting of SR splicing factors during mRNP maturation.

SRSF1 SRSF2

2.75e-052183216285923
Pubmed

SRSF1 and SRSF9 RNA binding proteins promote Wnt signalling-mediated tumorigenesis by enhancing β-catenin biosynthesis.

SRSF1 SRSF9

2.75e-052183223592547
Pubmed

Characterization and immunological identification of cDNA clones encoding two human DNA topoisomerase II isozymes.

TOP2A TOP2B

2.75e-05218322556712
Pubmed

Polo-like kinase 1 (PLK1) and protein phosphatase 6 (PP6) regulate DNA-dependent protein kinase catalytic subunit (DNA-PKcs) phosphorylation in mitosis.

PRKDC PLK1

2.75e-052183224844881
Pubmed

The Catalytic Subunit of DNA-Dependent Protein Kinase Coordinates with Polo-Like Kinase 1 to Facilitate Mitotic Entry.

PRKDC PLK1

2.75e-052183225925375
Pubmed

Roles of DNA topoisomerase II isozymes in chemotherapy and secondary malignancies.

TOP2A TOP2B

2.75e-052183217578914
Pubmed

Patient affected by neurofibromatosis type 1 and thyroid C-cell hyperplasia harboring pathogenic germ-line mutations in both NF1 and RET genes.

RET NF1

2.75e-052183224361808
Pubmed

RET mutation p.S891A in a Chinese family with familial medullary thyroid carcinoma and associated cutaneous amyloidosis binding OSMR variant p.G513D.

RET OSMR

2.75e-052183226356818
Pubmed

Molecular cloning and characterization of the human topoisomerase IIalpha and IIbeta genes: evidence for isoform evolution through gene duplication.

TOP2A TOP2B

2.75e-052183210095062
Pubmed

SRSF1 regulates the assembly of pre-mRNA processing factors in nuclear speckles.

SRSF1 SRSF2

2.75e-052183222855529
Pubmed

Functional compatibility between isoform alpha and beta of type II DNA topoisomerase.

TOP2A TOP2B

2.75e-052183214996935
Pubmed

Benzamil-mediated urine alkalization is caused by the inhibition of H+-K+-ATPases.

ATP12A ATP4A

2.75e-052183233554781
Pubmed

Natural variation in a single amino acid substitution underlies physiological responses to topoisomerase II poisons.

TOP2A TOP2B

2.75e-052183228700616
Pubmed

Predictors and mechanisms of epilepsy occurrence in cerebral gliomas: What to look for in clinicopathology.

TOP2A TOP2B

2.75e-052183228087392
Pubmed

Roles of the C-terminal domains of topoisomerase IIα and topoisomerase IIβ in regulation of the decatenation checkpoint.

TOP2A TOP2B

2.75e-052183228472494
Pubmed

Effects of altered expression and activity levels of CK1δ and ɛ on tumor growth and survival of colorectal cancer patients.

CSNK1D CSNK1E

2.75e-052183225404202
Pubmed

Meta-analysis of SHANK Mutations in Autism Spectrum Disorders: a gradient of severity in cognitive impairments.

SHANK1 SHANK2

2.75e-052183225188300
Pubmed

The distribution and expression of the two isoforms of DNA topoisomerase II in normal and neoplastic human tissues.

TOP2A TOP2B

2.75e-05218329155056
Pubmed

Active heterodimers are formed from human DNA topoisomerase II alpha and II beta isoforms.

TOP2A TOP2B

2.75e-05218328710863
Pubmed

Differential localization of MT1-MMP in human prostate cancer tissue: role of IGF-1R in MT1-MMP expression.

IGF1R MMP14

2.75e-052183218196535
Pubmed

Dopaminergic loss of cyclin-dependent kinase-like 5 recapitulates methylphenidate-remediable hyperlocomotion in mouse model of CDKL5 deficiency disorder.

SLC6A3 CDKL5

2.75e-052183232588892
Pubmed

Evidence for a mutant allele of the gene for DNA topoisomerase II in adriamycin-resistant P388 murine leukemia cells.

TOP2A TOP2B

2.75e-05218322555055
Pubmed

Polo-like kinase 1 regulates the stability of the mitotic centromere-associated kinesin in mitosis.

PLK1 KIF2C

2.75e-052183224931513
Pubmed

Doxorubicin-induced cardiotoxicity is maturation dependent due to the shift from topoisomerase IIα to IIβ in human stem cell derived cardiomyocytes.

TOP2A TOP2B

2.75e-052183231106979
Pubmed

A biochemical analysis of topoisomerase II alpha and beta kinase activity found in HIV-1 infected cells and virus.

TOP2A TOP2B

2.75e-052183216091284
Pubmed

RET signaling does not modulate MPTP toxicity but is required for regeneration of dopaminergic axon terminals.

RET SLC6A3

2.75e-052183218056810
Pubmed

CK1δ and CK1ε are components of human 40S subunit precursors required for cytoplasmic 40S maturation.

CSNK1D CSNK1E

2.75e-052183224424021
Pubmed

BioID screen of Salmonella type 3 secreted effectors reveals host factors involved in vacuole positioning and stability during infection.

HPS3 HPS5

2.75e-052183231611645
Pubmed

Mining topoisomerase isoforms in gastric cancer.

TOP2A TOP2B

2.75e-052183232535049
CytobandEnsembl 112 genes in cytogenetic band chr12q23

ANO4 HSP90B1 WASHC4 EID3 GAS2L3 NUAK1

3.28e-051501836chr12q23
GeneFamilyRNA binding motif containing|Serine and arginine rich splicing factors

SRSF1 SRSF2 SRSF8 SRSF9

1.00e-06121244737
GeneFamilyATPase H+/K+ transporting

ATP12A ATP4A

1.39e-04312421211
GeneFamilyBiogenesis of lysosomal organelles complex 2

HPS3 HPS5

1.39e-04312421038
GeneFamilyTopoisomerases

TOP2A TOP2B

6.87e-04612421050
GeneFamilyPhosphoinositide phosphatases

MTMR1 MTMR14 FIG4

1.35e-033212431079
GeneFamilyMAGE family

MAGEL2 MAGEH1 NSMCE3

2.59e-034012431136
GeneFamilyReceptor Tyrosine Kinases|CD molecules

FLT1 RET IGF1R

2.59e-03401243321
CoexpressionYAGI_AML_WITH_INV_16_TRANSLOCATION

FLT1 ERBB4 DPY19L1 UBE2C CDKL5 RNF167 NF1 CSNK1D CSNK1E SRSF8 TAF1 OSMR ATP12A TOP2A

1.29e-0641118314M1047
CoexpressionFIRESTEIN_PROLIFERATION

CDKL5 NF1 CSNK1E RPS6KA6 PRKAR2A CPNE1 PRKDC TAF1

2.28e-051661838M5354
CoexpressionBIDUS_METASTASIS_UP

SRSF1 SRSF2 GAS2L3 EIF4A3 UBE2C SMC4 NF1 PRKDC SRSF9

2.68e-052211839M15866
CoexpressionCAIRO_HEPATOBLASTOMA_CLASSES_UP

SRSF1 SRSF2 BZW2 EIF4A3 UBE2C SMC4 BYSL CPNE1 PRKDC PLK1 SRSF9 TOP2A PUS7 MAN1B1 KIF2C

2.80e-0561218315M4772
CoexpressionCHUANG_OXIDATIVE_STRESS_RESPONSE_DN

UBE2C NAB2 PLK1

5.30e-05111833M12948
CoexpressionHALLMARK_MITOTIC_SPINDLE

RAPGEF5 SMC4 NF1 CSNK1D PLK1 TOP2A TBCD KIF2C

8.25e-051991838M5893
CoexpressionGSE27786_LSK_VS_ERYTHROBLAST_UP

WASHC4 FLYWCH1 MRPL27 NDUFS3 NFIC RPS6KA6 DLG3 PWWP3B

8.54e-052001838M4757
CoexpressionGSE27859_DC_VS_CD11C_INT_F480_INT_DC_DN

MYO5A EIF4A3 UTP25 FIG4 BYSL TADA2A PLK1 SRSF9

8.54e-052001838M8600
CoexpressionGSE1740_MCSF_VS_MCSF_AND_IFNG_DAY2_DERIVED_MACROPHAGE_WITH_IFNA_STIM_UP

GAS2L3 BZW2 VPS26B ZZEF1 SLC6A6 FIG4 EEPD1 PRKDC

8.54e-052001838M6158
CoexpressionGSE1112_OT1_VS_HY_CD8AB_THYMOCYTE_RTOC_CULTURE_DN

GAS2L3 BZW2 VPS26B NSMCE3 ZZEF1 NFIC EEPD1 GFM1

8.54e-052001838M6146
CoexpressionGSE31082_DP_VS_CD8_SP_THYMOCYTE_UP

SMC4 PPP4R3B MTMR14 CPNE1 DLG3 PLK1 GPR132 PSD4

8.54e-052001838M5066
CoexpressionGSE17721_POLYIC_VS_GARDIQUIMOD_12H_BMDC_DN

HSP90B1 SMC4 RAD50 FASN TTC7B MANF RARS2 SRSF9

8.54e-052001838M4030
CoexpressionHALLMARK_E2F_TARGETS

SRSF1 SRSF2 SMC4 RAD50 PRKDC PLK1 TOP2A KIF2C

8.54e-052001838M5925
CoexpressionGSE20715_0H_VS_48H_OZONE_LUNG_UP

MYO1G PGAP4 HPS3 RAD50 SLC6A6 FIG4 PLXNC1 ELF5

8.54e-052001838M4368
CoexpressionRHODES_CANCER_META_SIGNATURE

HSP90B1 EIF4A3 MANF PLK1 TOP2A

9.24e-05651835M1345
ToppCelldroplet-Mammary_Gland-nan-21m-Endothelial-basal_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FLT1 FLYWCH1 CCDC61 HEPH TBC1D24 STARD6 MTMR14 RPS6KA6

6.98e-07176183827e5115fae5f0f63b333bc99fbf6a6d4c9182c46
ToppCell3'-GW_trimst-1.5-SmallIntestine-Neuronal-Glial_immature-cycling_ENCC/glia|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

GAS2L3 UBE2C SMC4 AP1S2 CMTM5 PLK1 TOP2A KIF2C

9.37e-07183183829b62dd542bc3f8df843998f577724f3818d4271
ToppCellLPS-antiTNF-Unknown-Endothelial-Pericyte_2|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SHANK1 GAS2L3 LAMC3 RYR2 PLK1 TOP2A KIF2C

1.26e-06132183702491930097b75aaeedab9e8200711b0dc610944
ToppCellBrain_organoid|World / Sample Type, Dataset, Time_group, and Cell type.

NSMCE3 PRR7 PPP4R3B CSNK1E BUD31 PRKAR2A PFDN6 SRSF9

1.29e-061911838d93b280124b9888cd3f199d025bd6c7a1a709f2a
ToppCell11.5-Airway-Epithelial-Neuroendocrine|Airway / Age, Tissue, Lineage and Cell class

BEST3 RET CHRNB2 KCNH6 RUNDC3A KCNH2 PLS1 CKMT1A

1.29e-061911838c1bb3ae5c297f55cdadf5b6e53d5296389d5099e
ToppCellNon-neuronal-Dividing-Radial_Glia-Low_Quality-16|World / Primary Cells by Cluster

SRSF2 EIF4A3 UBE2C SMC4 PLK1 SRSF9 TOP2A KIF2C

1.34e-0619218380d6413df15dfecdffc777fb02df3aaf0c30540b1
ToppCellNon-neuronal-Dividing-Radial_Glia-Low_Quality|World / Primary Cells by Cluster

SRSF2 EIF4A3 UBE2C SMC4 PLK1 SRSF9 TOP2A KIF2C

1.34e-0619218385fa5b2f250ec5ad5a232c022266f0cd01ff4a753
ToppCell(3)_Chondrocytes-(33)_Chondro-prol/rest|World / Cell class and subclass of bone marrow stroma cells in homeostatis

GAS2L3 UBE2C SMC4 FASN CMTM5 PLK1 TOP2A KIF2C

1.45e-061941838c093c5e161b97ad770bfbaad3023eba4537101b5
ToppCell10x_3'_v2v3-Neoplastic-Differentiated-like-AC-like-AC-like_Prolif-E|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

GAS2L3 UBE2C SMC4 NFIC PRKDC PLK1 TOP2A KIF2C

1.69e-0619818387225a6194c52b01c581e58d3cda107c4af96dc4f
ToppCellSepsis-Bac-SEP-Lymphocyte-B-Plasmablast|Bac-SEP / Disease, condition lineage and cell class

UBE2C SMC4 PKHD1L1 CCNC MANF PLK1 TOP2A KIF2C

1.69e-061981838614055c11d1dd2f3f2b8783ec35a8f4570cad161
ToppCellSigmoid-Dendritic_cell-cycling_DCs|Sigmoid / Region, Cell class and subclass

GAS2L3 LILRB2 ADAM9 UBE2C MMP14 PLK1 TOP2A KIF2C

1.75e-061991838bd6f8c0f79e9a94cc0f8c6105d38851463de821c
ToppCellSigmoid-(5)_Dendritic_cell-(52)_cycling_DCs|Sigmoid / shred on region, Cell_type, and subtype

GAS2L3 LILRB2 ADAM9 UBE2C MMP14 PLK1 TOP2A KIF2C

1.75e-0619918388ee78a39729633bcbb3ab17e1dfaca33f38db569
ToppCellSevere-Developping_Plasmablast|Severe / disease group and sub_cluster of B and Plasma cells(res = 0.5)

HSP90B1 EIF4A3 UBE2C SMC4 MANF PLK1 TOP2A KIF2C

1.82e-0620018386d0cd00e52568d23597cc2a4059bd967d7d2dab5
ToppCellCOVID-19_Mild-Neu_0|World / 5 Neutrophil clusters in COVID-19 patients

BEST3 FAM227B UTP25 ADGRG2 DLG3 CCR5 ABCD2

1.87e-06140183793f024473b1bb3bf93ae776fd6a8fc5e93d013f0
ToppCellfacs-Pancreas-Exocrine-3m-Epithelial-nan|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EID3 NTNG1 MSH3 CCDC177 CHRNB2 TRPM5 PWWP3B

3.68e-061551837441fcb6d05364fc6f4973f0b973f1a80b573ce1f
ToppCellE18.5-Immune-Immune_Myeloid-Monocytic-Macrophage-iMON-iMON_G2M|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MYO1G BTBD8 ACER3 USP25 ARHGAP30 CCR5 TOP2A

4.00e-061571837904cd98ae85ed6459e0663f077ac462842bf12df
ToppCellPND01-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_G2M|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MYO1G GAS2L3 UBE2C PLK1 GPR132 TOP2A KIF2C

6.25e-06168183752fd65024af8683db11d931f7563cbe8eb815d1c
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c13-MKI67-CCL5_l|Severe-critical_progression_d12-22 / Compartment, severity and other cell annotations on 10x 3' data (130k)

DOLK HPS3 BYSL CCR5 PLK1 TOP2A KIF2C

6.75e-06170183712aa9bdb18f3bf6da2a25984d08fe9497e5570ed
ToppCellPCW_05-06-Mesenchymal-Mesenchymal_cycling-mes_proliferating1_(15)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

HSP90B1 GAS2L3 UBE2C SMC4 PLK1 TOP2A KIF2C

7.29e-0617218377f3d0ef18f5df1ed80498d435b0378ca398c0b88
ToppCellPND03-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_G2M|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

GAS2L3 UBE2C SMC4 ABCD2 PLK1 TOP2A KIF2C

7.86e-06174183765147b0f8c2ccadd5685430d31081520c157536a
ToppCellPND10-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_T-Treg-Treg_G2M|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

GAS2L3 UBE2C SMC4 CCR5 PLK1 TOP2A KIF2C

8.16e-0617518379de288c338cee67be0e9b836c87799bbc1db1c38
ToppCellNS-moderate-d_0-4-Lymphoid-NKT-proliferating|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

GAS2L3 UBE2C SMC4 DEPDC7 PLK1 TOP2A KIF2C

8.79e-061771837174c54acfe19e2bb31418d69e228032ba724cbb6
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Cycling_Endothelial_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

FLT1 GAS2L3 RAPGEF5 UBE2C SMC4 TOP2A KIF2C

8.79e-06177183773ba0f0b4b33f10e9f036d6d9befa48a1258e682
ToppCellPND10-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT2-AT2_G2M|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

GAS2L3 UBE2C SMC4 SH2D4A PLK1 TOP2A KIF2C

8.79e-0617718373081ce5fc66a1bb833719d6c0e0a6fc7115eeb91
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_cycling-mes_proliferating1_(15)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

HSP90B1 GAS2L3 UBE2C SMC4 PLK1 TOP2A KIF2C

9.45e-0617918376718cadcc2d3b64717ed84244ef1242d392662dc
ToppCellPCW_07-8.5-Mesenchymal-Mesenchymal_cycling-mes_proliferating1_(15)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

HSP90B1 GAS2L3 UBE2C SMC4 PLK1 TOP2A KIF2C

9.80e-061801837ed4966765a6b25456f68185cf0648c4a3a21d7fe
ToppCellnormal_Lung-Myeloid_cells-CD207+CD1a+_LCs|normal_Lung / Location, Cell class and cell subclass

GAS2L3 SUCNR1 PLXNC1 OLFM2 DEPDC7 PLK1 KIF2C

1.02e-051811837b55dbcfae8c92d322071906831489830a22239b9
ToppCell356C-Lymphocytic-CD4_T-cell-Proliferating_T_cell|356C / Donor, Lineage, Cell class and subclass (all cells)

UBE2C SMC4 SDR9C7 KCNH2 PLK1 TOP2A KIF2C

1.02e-051811837be4f35c9eb5b3083acb2264128f095fac1f3da45
ToppCelldroplet-Lung-18m-Hematologic-myeloid-classical_monocyte_proliferating|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

RUNDC3A AP5B1 EEPD1 DEPDC7 PLK1 ATP4A TOP2A

1.09e-0518318376c1d7ce60e67bf1df364a4e177c351e7313eb41f
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_cycling-mes_proliferating1_(15)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

HSP90B1 GAS2L3 UBE2C SMC4 PLK1 TOP2A KIF2C

1.17e-0518518376aeae77a087d695b1e58c5f63265e7113aa2e343
ToppCellsystemic_lupus_erythematosus-managed-Lymphocytic_B-plasmablast-female|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

UBE2C PKHD1L1 MANF PLK1 TOP2A CKMT1A KIF2C

1.30e-051881837ecba5d06cbf3254448255a2aeefffe711f43310e
ToppCellsystemic_lupus_erythematosus-managed-Lymphocytic_B-plasmablast|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

UBE2C PKHD1L1 MANF PLK1 TOP2A CKMT1A KIF2C

1.30e-0518818378cf135da4d1d2500755d2809d60b41509af9fa8b
ToppCellBac-SEP-Lymphocyte-B-Plasmablast|Bac-SEP / Disease, Lineage and Cell Type

UBE2C SMC4 PKHD1L1 MANF PLK1 TOP2A KIF2C

1.35e-0518918376339b6d1056e07cefb0e1b2a0e479913c5783c8a
ToppCellE15.5-Mesenchymal-developing_mesenchymal_cell-mesenchymal_proliferating_cell|E15.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

GAS2L3 UBE2C SMC4 NTNG1 PLK1 TOP2A KIF2C

1.35e-051891837d049f33115610bda4489968759f754730698b9cd
ToppCell15-Trachea-Epithelial-Neuroendocrine|Trachea / Age, Tissue, Lineage and Cell class

BEST3 RET SUCNR1 KCNH6 RUNDC3A KCNH2 TNR

1.44e-05191183776311fa5f3ae9bb27cf04387a8c92300f2888c28
ToppCellTCGA-Stomach-Primary_Tumor-Stomach_Adenocarcinoma-Stomach_Adenocarcinoma_-_NOS-6|TCGA-Stomach / Sample_Type by Project: Shred V9

DPY19L1 ADAM9 TTI2 HPS3 SH2D4A GFM1 PLS1

1.49e-0519218374e689bca7a242f8482e25f273656e2caba8821c0
ToppCell10x_3'_v2v3-Neoplastic-Stem-like-NPC-like-NPC-like_Prolif-D|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

GAS2L3 UBE2C SMC4 SLC6A3 PLK1 TOP2A KIF2C

1.49e-051921837f518839ecd9377537a414e8798766f7d91eafeac
ToppCellAdult-Immune-alveolar_macrophage_(MARCO_positive)-D175|Adult / Lineage, Cell type, age group and donor

ACER3 GAS2L3 MYO5A ARHGAP30 SLC6A6 TTC7B EEPD1

1.49e-051921837733491e932350e3c216a626cc49c3cd3fe970a82
ToppCell5'-GW_trimst-2-SmallIntestine-Neuronal-Glial_immature-cycling_ENCC/glia|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

UBE2C SMC4 AP1S2 CMTM5 PLK1 TOP2A KIF2C

1.54e-051931837e7b2d99342e3eb4a05d298c2f124dd20bed8a743
ToppCellPCW_13-14-Epithelial-Epithelial_proliferating-epi_proliferating2_(13)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

ERBB4 UBE2C SHANK2 PLK1 PLS1 TOP2A KIF2C

1.59e-051941837c197e4acbff42a9f0410b6801c2bfcf6160aefc1
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

ERBB4 RAPGEF5 FASN PTPRD SHANK2 RHOBTB2 LARGE1

1.59e-05194183797534c8bba895a7913665e03ae4e5c4a6ad71daf
ToppCellBALF-PFMC|World / Compartment, severity and other cell annotations on 10x 3' data (130k)

UBE2C NSMCE3 FASN RPS6KA6 CCR5 TOP2A KIF2C

1.70e-051961837d9a0f608e0d688d19d46e95fe73eff238aae88eb
ToppCellTracheal-10x5prime-Epithelial-Epi_airway_neuro-secretory-Ionocyte_n_Brush|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

ANO4 PRMT8 BEST3 RET ITIH5 TTC7B KCNH2

1.70e-05196183750aaca81b593ff71790bb75403b2e4c3ab03a6d2
ToppCellTracheal-NucSeq-Epithelial-Epi_airway_neuro-secretory|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ANO4 BEST3 RET SUCNR1 KCNH6 KCNH2 PWWP3B

1.70e-05196183772b6a68ee760599ea86cd2d712bfd17b7b4ee417
ToppCell3'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophage_proliferating-Alveolar_macrophage_proliferating_L.1.0.7.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

UBE2C SMC4 PKHD1L1 NUAK1 PLK1 TOP2A KIF2C

1.70e-051961837eb8c9a4a5eb21d43ff7b25deae5896c236f669b9
ToppCellParenchymal-NucSeq-Epithelial-Epi_airway_neuro-secretory-Neuroendocrine|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ANO4 BEST3 RET KCNH6 RUNDC3A KCNH2 TNR

1.82e-0519818378f25e8dff42bad8e779ca618bdb1cb1610667962
ToppCell5'-GW_trimst-2-SmallIntestine-Endothelial-blood_vessel_EC-Mature_venous_EC|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FLT1 RAPGEF5 UBE2C SMC4 PLK1 TOP2A KIF2C

1.82e-051981837604fb20ca1aaf8f07067a8e1593a30ba335891f7
ToppCellPBMC-Severe-Lymphocyte-B-Plasmablast-Plasmablast-Developping_Plasmablast|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

HSP90B1 UBE2C SMC4 MANF PLK1 TOP2A KIF2C

1.82e-0519818372d8d4eb21b4fe3cc178b3518b3ea39c2d9650f24
ToppCellEndothelial-H_(cycle)|World / shred on cell class and cell subclass (v4)

GAS2L3 UBE2C SMC4 PLK1 TOP2A KIF2C

1.86e-0513318368e3005114761feee028c496cc739e607b35d7831
ToppCell3'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2_proliferating-AT2_proliferating_L.0.1.2.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

UBE2C SMC4 FASN RHOBTB2 PLK1 TOP2A KIF2C

1.88e-051991837d7dbc551c05da32c698908348572fb0ce1166e10
ToppCellNon-neuronal-Dividing-IPC-IPC-div1-28|World / Primary Cells by Cluster

HSP90B1 GAS2L3 UBE2C SMC4 PLK1 TOP2A KIF2C

1.88e-051991837787688b68ae5d8768c0a24673ae07ab07616764a
ToppCellNon-neuronal-Dividing-IPC-IPC-div1|World / Primary Cells by Cluster

HSP90B1 GAS2L3 UBE2C SMC4 PLK1 TOP2A KIF2C

1.88e-05199183772823f26ecabcae1b514b7629cfce010c97b929a
ToppCell3'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2_proliferating|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

UBE2C SMC4 FASN RHOBTB2 PLK1 TOP2A KIF2C

1.88e-0519918376a89c3a65fa50af92585c52bec203bcff6f94efc
ToppCellTransverse-T_cell-Tfh|Transverse / Region, Cell class and subclass

FLYWCH1 NATD1 ITIH5 TBC1D24 GFM1 GPR132 MAN1B1

1.88e-051991837cbef8f95edf2e86e16c448a76068d7ed8f6b7748
ToppCellTransverse-(1)_T_cell-(16)_Tfh|Transverse / shred on region, Cell_type, and subtype

FLYWCH1 NATD1 ITIH5 TBC1D24 GFM1 GPR132 MAN1B1

1.88e-051991837aa31e26d48066f865ca33251a33a28934c0a7a44
ToppCellMild/Remission-Developping_Plasmablast|Mild/Remission / disease group and sub_cluster of B and Plasma cells(res = 0.5)

HSP90B1 UBE2C SMC4 MANF PLK1 TOP2A KIF2C

1.88e-05199183758c772ec763109a4009f52424fbb214fc23d0c09
ToppCellBrain_organoid-organoid_Paulsen_bioRxiv-3.5_mon-Proliferating-Cycling_IN_Progenitors|3.5_mon / Sample Type, Dataset, Time_group, and Cell type.

GAS2L3 UBE2C SMC4 BEST3 PLK1 TOP2A KIF2C

1.88e-051991837f315ec3fb6c0799668c9195f836a77fc0db2b615
ToppCell(5)_Plasmablast|World / Spleen cell shreds - cell class (v1) and cell subclass (v1)

HSP90B1 UBE2C SMC4 MANF PLK1 TOP2A KIF2C

1.88e-051991837f7d2ce4066436bbfe78150b579d22371a93ba76d
ToppCellTCGA-Stomach-Primary_Tumor|TCGA-Stomach / Sample_Type by Project: Shred V9

SRSF1 UBE2C UTP25 PLK1 TOP2A PUS7 KIF2C

1.88e-05199183738f1f612b29feb868322999ceeda78e52447ec4f
ToppCellTCGA-Stomach-Primary_Tumor-Stomach_Adenocarcinoma|TCGA-Stomach / Sample_Type by Project: Shred V9

SRSF1 UBE2C UTP25 PLK1 TOP2A PUS7 KIF2C

1.88e-051991837b10698aee2e6c17bc559eb4f723024141f914b90
ToppCellMild/Remission-Developping_Plasmablast|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)

HSP90B1 UBE2C SMC4 MANF PLK1 TOP2A KIF2C

1.88e-0519918371dda6116de639140c2d6f5012b7ab9ad0f737ae1
ToppCell3'-GW_trimst-1-LargeIntestine-Neuronal-Glial_immature-cycling_ENCC/glia|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ERBB4 UBE2C SMC4 RET AP1S2 CMTM5 TOP2A

1.88e-0519918379940f347973bf976ee23fb4b1cf1f349d96c21df
ToppCellLung_Parenchyma-Severe-Hematopoietic-RBC-RBC|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

NATD1 UBE2C ABCB6 PKDREJ RUNDC3A KCNH2 TOP2A

1.94e-052001837b5f2892bc45fda5ae05e269b840305a608a07c37
ToppCellLung_Parenchyma-Severe-Hematopoietic-RBC|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

NATD1 UBE2C ABCB6 PKDREJ RUNDC3A KCNH2 TOP2A

1.94e-0520018379ce1f91991637fc3af0f6a80a85e1a44276fe412
ToppCellLPS_IL1RA_TNF-Epithelial_airway-airway_epithelial|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

CCDC146 CRNN ELF5 ATP12A CCDC180 CFAP99 CKMT1A

1.94e-052001837da12821e8a0657869ca0f75d351cce2d7605a505
ToppCell3'-GW_trimst-1-SmallIntestine-Mesenchymal-immature_mesenchymal_cell-cycling_stromal|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

GAS2L3 UBE2C SMC4 GPC4 PLK1 TOP2A KIF2C

1.94e-052001837dd5b753bb1333fa502b9d3a6d65a53a9882b2451
ToppCellLung_Parenchyma-Severe-Hematopoietic|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

NATD1 UBE2C ABCB6 PKDREJ RUNDC3A KCNH2 TOP2A

1.94e-052001837fdf3e60cf94f398a56c0fa72813d0459f5ce081b
ToppCell10x_3'_v2v3-Neoplastic-Differentiated-like-AC-like-AC-like_Prolif|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

GAS2L3 UBE2C SMC4 NFIC PLK1 TOP2A KIF2C

1.94e-0520018370de9e7412a1725a8acd51820aa3135a112ced36c
ToppCellLung_Parenchyma-Severe-Hematopoietic-RBC-RBC-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

NATD1 UBE2C ABCB6 PKDREJ RUNDC3A KCNH2 TOP2A

1.94e-052001837199165be1aef8497af71b74690a11de18fbe073c
ToppCellParenchyma_COVID-19-Stromal-TX-Erythrocytes|Parenchyma_COVID-19 / Sample group, Lineage and Cell type

NATD1 UBE2C ABCB6 PKDREJ RUNDC3A KCNH2 TOP2A

1.94e-052001837a9edac2f5e009662df452ec032a80e855cdac28f
ToppCellSevere-Developping_Plasmablast|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)

HSP90B1 UBE2C SMC4 MANF PLK1 TOP2A KIF2C

1.94e-05200183780639e0d2ddaae36ac7634a4f03e8809af7316e3
ToppCellLPS_IL1RA_TNF-Epithelial_airway|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

CCDC146 CRNN ELF5 ATP12A CCDC180 CFAP99 CKMT1A

1.94e-05200183772c1d9eeaed4b3ee6b6c602e8aa29efc2e8744eb
ToppCell(52)_cycling_DCs|World / shred on Cell_type and subtype

GAS2L3 LILRB2 UBE2C MMP14 PLK1 TOP2A KIF2C

2.00e-052011837ad2d25d84345fdd593065516a05c5c2b5429eac0
ToppCellEndothelial-Endothelial-H_(cycle)|Endothelial / shred on cell class and cell subclass (v4)

GAS2L3 UBE2C SMC4 PLK1 TOP2A KIF2C

2.30e-051381836a1f41a5a9da40adcc343722baef78c603599c3f0
ToppCellLPS-antiTNF-Epithelial_alveolar-Mes-Like-AT2_Progenitor|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

GAS2L3 LAMC3 ELF5 PLK1 TOP2A KIF2C

3.81e-051511836c06a54afe918b14f885d6a85fbcf81e80f33afae
ToppCellPND07-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_G2M|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

EOGT UBE2C RET IGF1R NUAK1 PLK1

4.41e-0515518368e239470799426ea474a36f57e1b7e0d9365ca5f
ToppCellmild_COVID-19_(asymptomatic)-Plasmablast|mild_COVID-19_(asymptomatic) / disease group, cell group and cell class (v2)

UBE2C MAGEH1 PKHD1L1 PLS1 TOP2A PUS7

6.46e-0516618360cc3b9681bc000a1b00d3b60f79f16eea1c2e2e1
ToppCellCerebellum-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)|Cerebellum / BrainAtlas - Mouse McCarroll V32

SHANK1 CLSTN3 PRMT8 RET CHRNB2 SHANK2

6.68e-0516718369efb9511a211d0824bb97f82c1a5860c43d2138f
ToppCellCerebellum-Neuronal-Inhibitory|Cerebellum / BrainAtlas - Mouse McCarroll V32

SHANK1 CLSTN3 PRMT8 RET CHRNB2 SHANK2

6.68e-051671836904c613aac3f9919a432b110bb1dcc832b5aec0a
ToppCellPND14-Immune-Immune_Myeloid-DC-cDC2-cDC2_G2M|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

UBE2C SMC4 CCR5 PLK1 TOP2A KIF2C

6.90e-051681836b7cd33f5da4f37b9384fc3bd3ca01fbc790accfc
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_G2M|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

GAS2L3 UBE2C SMC4 PLK1 TOP2A KIF2C

7.13e-051691836b253a4a50c06d36228fcd5d856c57202cbac158f
ToppCellHippocampus-Neuronal-Inhibitory-iN2(Gad1Gad2)|Hippocampus / BrainAtlas - Mouse McCarroll V32

ERBB4 MAGEL2 BEND4 TRAPPC13 KCNH2 AP1S2

7.13e-051691836c135d7ae0490d0024e0f4bd8c4ad42f6674a61da
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Immune-Myeloid-Macrophage_Dendritic-Cycling_Mononuclear_Phagocyte|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

UBE2C SMC4 BEND4 PLXNC1 TOP2A KIF2C

7.13e-05169183654b13ab02b4c187f4754045ecfcf409749e7ccc0
ToppCellBL-critical-LOC-Epithelial-Ionocyte|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

BEST3 RET ITIH5 KCNH2 RPS6KA6 PWWP3B

7.37e-051701836b465df2dac6b4e98b4ede6ad0c6347656757885c
ToppCell5'-GW_trimst-1-SmallIntestine-Mesenchymal-fibroblastic-Stromal_1_(ADAMDEC1+)|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

GAS2L3 UBE2C SMC4 PLK1 TOP2A KIF2C

7.61e-05171183605014cf6746e6663e376fdd681f1b43a7081c603
ToppCellE18.5-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-Sox9_Epi-Sox9_Epi_G2M|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

GAS2L3 UBE2C SMC4 PLK1 TOP2A KIF2C

7.61e-051711836621f9da0bfa09c86fc89fd26919403e94cd56d2b
ToppCell5'-GW_trimst-1-SmallIntestine-Mesenchymal-fibroblastic|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

GAS2L3 UBE2C SMC4 PLK1 TOP2A KIF2C

7.61e-051711836d6114db2292fbb27b39d090d51fd305a135b1ccf
ToppCellfacs-Thymus-Flowthrough-3m-Myeloid|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYO5A SUCNR1 NPHP3 NF1 PLXNC1 CCDC180

7.86e-051721836356a66cd9303470e427005cc67fdd22a2c4bf971
ToppCellfacs-Thymus-Flowthrough-3m-Myeloid-macrophage|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYO5A SUCNR1 NPHP3 NF1 PLXNC1 CCDC180

7.86e-05172183646fadeee483fdf8402df92ec98575a09c6c15b16
ToppCellCD8+_Memory_T_cell-FLU-3|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster

DPY19L1 ADAM9 UBE2C TBC1D24 CCDC180 KIF2C

7.86e-05172183645ac433dbb3796f69e886c04457b2971403050ee
ToppCellfacs-Thymus-Flowthrough-3m-Myeloid-macrophage|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYO5A SUCNR1 NPHP3 NF1 PLXNC1 CCDC180

7.86e-051721836438d2e7f1897668a14d85ca70722e5d0102606dc
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell_prolif|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

FLT1 RAPGEF5 ABCB6 PKHD1L1 NUAK1 TBCD

7.86e-051721836c056d44e2e130ceccadfcdceb192a7f095d779c8
ToppCellfacs-Brain_Non-Myeloid-Cerebellum_-18m-Epithelial-neuronal_stem_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GAS2L3 UBE2C RPS6KA6 PLK1 TOP2A KIF2C

8.11e-051731836f38bf7584e08d15a6e2c116b7c3551ba475a5e14
ToppCell5'-Adult-LargeIntestine-Hematopoietic-B_cells-Cycling_B_cell|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

RAPGEF5 UBE2C SMC4 PLK1 TOP2A KIF2C

8.11e-051731836b7e0193fd4983cb38d1bee441f608f73ee8743b9
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_G2M|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

GAS2L3 UBE2C SMC4 PLK1 TOP2A KIF2C

8.37e-051741836dbb4e1a6c3319ce40f81bfd2d1745a88a2cc412e
ToppCellPND03-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF-SCMF_G2M|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

UBE2C HEPH ADGRG2 PLK1 TOP2A KIF2C

8.37e-0517418367b2f35add804981c7d588a996bdbca6ec11a1ca5
ToppCell10x5'-GI_small-bowel-Lymphocytic_T_CD4/8-lo-Cycling_T|GI_small-bowel / Manually curated celltypes from each tissue

GAS2L3 UBE2C SMC4 PLK1 TOP2A KIF2C

8.37e-051741836e4c8da80eca07e4396f57dad212f76c2eca4c1bd
ToppCellE16.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte-Pericyte_G2M|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

EOGT MAGEL2 UBE2C SMC4 ITIH5 TOP2A

8.64e-051751836fa16c6ba08dc0cc22e8cf049db0577811d080df6
ToppCellfacs-Marrow-T-cells-24m-Hematologic-hematopoietic_stem_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HSP90B1 OOSP2 SLC6A3 KCNH6 MANF PLS1

8.64e-0517518360a01e0104cfa3091bc05b0f1d087c941688169a5
ToppCell367C-Lymphocytic-NK_cells-Proliferating_NK_cell|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

GAS2L3 LILRB2 UBE2C PLK1 TOP2A KIF2C

8.64e-0517518360b1aaa028ba844d4bcb4509fdab8bee648373935
DrugThiocolchicoside [602-41-5]; Down 200; 7uM; PC3; HT_HG-U133A

TMEM186 SRSF1 SMG5 PPP4R3B IGF1R SHANK2 CSNK1E PRKAR2A DLG3 OSMR LARGE1

6.63e-07199183115095_DN
Drugrapamycin; Down 200; 0.1uM; HL60; HG-U133A

LILRB2 SMC4 TFIP11 SMG5 MSH3 ZZEF1 FASN HSPA9 MAN1B1 TBCD

4.63e-0619718310362_DN
DrugTrichostatin A, Streptomyces sp.; Down 200; 1uM; MCF7; HT_HG-U133A

EOGT MTMR1 SMG5 RET PPP4R3B IGF1R SH2D4A UTP25 NFIC

9.52e-0616918395231_DN
DrugThiosemicarbazones

SRSF2 RAD50 KCNH6 FASN IGF1R TOP2A

1.26e-05641836ctd:D013882
DrugTrichostatin A, from Streptomyces sp.; Down 200; 0.1uM; MCF7; HT_HG-U133A

NAB2 MTMR1 MSH3 SH2D4A NF1 NUAK1 NFIC OSMR PLK1

1.32e-0517618396784_DN
DrugTrichostatin A, Streptomyces sp.; Down 200; 0.1uM; MCF7; HT_HG-U133A

EOGT MTMR1 MSH3 IGF1R UTP25 NUAK1 CSNK1E NFIC KCTD15

1.38e-0517718396972_DN
DrugFluspirilen [1841-19-6]; Down 200; 8.4uM; PC3; HT_HG-U133A

DOCK1 SRSF1 NAB2 MAGEH1 RYR2 IGF1R NF1 PLXNC1 TADA2A

2.97e-0519518396662_DN
DrugNSC302991

SRSF1 SRSF2 ABCB6 PKDREJ RAD50 IGF1R NUAK1 ADGRG2 CSNK1D PRKDC PLK1 TOP2B

3.05e-0535318312CID000002538
DrugDimethadione [695-53-4]; Down 200; 31uM; HL60; HT_HG-U133A

RNGTT LILRB2 NAB2 SMG5 SLC6A6 TRAPPC13 PLXNC1 RPS6KA6 PRKAR2A

3.10e-0519618393029_DN
DrugChlorpropamide [94-20-2]; Up 200; 14.4uM; MCF7; HT_HG-U133A

CLSTN3 RAPGEF5 PGAP4 PKDREJ IGF1R SHANK2 ADGRG2 RHOBTB2 DLG3

3.10e-0519618393210_UP
DrugH-7 dihydrochloride; Up 200; 100uM; PC3; HT_HG-U133A

HSP90B1 FLT1 RAPGEF5 PTPRU NF1 SHANK2 ADGRG2 KCNH2 TBCD

3.49e-0519918395968_UP
DrugEucatropine hydrochloride [536-93-6]; Down 200; 12.2uM; PC3; HT_HG-U133A

NAB2 MAGEH1 RYR2 NF1 SHANK2 DLG3 OSMR MMP14 TBCD

3.49e-0519918393759_DN
DrugSpironolactone [52-01-7]; Down 200; 9.6uM; PC3; HT_HG-U133A

DOCK1 RAPGEF5 LAMC3 RYR2 PPP4R3B NF1 CSNK1E DLG3 OSMR

3.49e-0519918395781_DN
DiseaseIntellectual Disability

EIF4A3 TTI2 KIF7 SLC6A3 FASN NF1 SHANK2 RHOBTB2 RNASET2 TAF1 PUS7 MAN1B1 TBCD LARGE1

5.08e-0744717514C3714756
DiseaseProfound Mental Retardation

TTI2 KIF7 FASN NF1 SHANK2 MAN1B1 TBCD

2.02e-051391757C0020796
DiseaseMental Retardation, Psychosocial

TTI2 KIF7 FASN NF1 SHANK2 MAN1B1 TBCD

2.02e-051391757C0025363
DiseaseMental deficiency

TTI2 KIF7 FASN NF1 SHANK2 MAN1B1 TBCD

2.02e-051391757C0917816
DiseaseAdenocarcinoma of lung (disorder)

FLT1 BZW2 MSH3 FASN CSNK1E RPS6KA6 PRKDC TOP2A

3.37e-052061758C0152013
Diseasepulmonary neuroendocrine tumor (is_marker_for)

SRSF2 RNASET2

3.50e-0521752DOID:5410 (is_marker_for)
DiseaseB cell deficiency (implicated_via_orthology)

TOP2A TOP2B

3.50e-0521752DOID:2115 (implicated_via_orthology)
DiseaseSquamous cell carcinoma of lung

ERBB4 IGF1R PRKDC PLK1

3.78e-05321754C0149782
Diseaserheumatoid arthritis (implicated_via_orthology)

MMP14 NCF1C NCF1B

4.34e-05121753DOID:7148 (implicated_via_orthology)
DiseaseParkinsonism (biomarker_via_orthology)

RET NDUFS3 SLC6A3 HSPA9

4.82e-05341754DOID:0080855 (biomarker_via_orthology)
DiseaseMental Retardation, X-Linked Nonsyndromic

GDI1 AP1S2 DLG3

5.61e-05131753C3501611
DiseaseColorectal Carcinoma

SHANK1 CLSTN3 NTNG1 ABCB6 RET PTPRU HPS3 CDKL5 NF1 PTPRD AKAP9 DLG3 OLFM2 ABCD2

8.24e-0570217514C0009402
Diseaseshort QT syndrome (implicated_via_orthology)

KCNH6 KCNH2

1.05e-0431752DOID:0050793 (implicated_via_orthology)
DiseaseTransitional cell carcinoma of bladder

FLT1 RET

2.08e-0441752C0279680
DiseaseLiposarcoma, Pleomorphic

FASN NF1

2.08e-0441752C0205825
Diseaseexercise test

LRIT3 RYR2 PTPRD

2.17e-04201753EFO_0004328
DiseaseAttention Deficit Disorder

CHRNB2 SLC6A3 PTPRD

2.91e-04221753C0041671
DiseaseMinimal Brain Dysfunction

CHRNB2 SLC6A3 PTPRD

2.91e-04221753C1321905
Diseasechronic granulomatous disease (implicated_via_orthology)

NCF1C NCF1B

3.46e-0451752DOID:3265 (implicated_via_orthology)
DiseaseRett Syndrome, Atypical

NTNG1 CDKL5

3.46e-0451752C2748910
DiseaseAttention deficit hyperactivity disorder

CHRNB2 SLC6A3 PTPRD

3.79e-04241753C1263846
Diseaseliposarcoma

FASN NF1

5.16e-0461752C0023827
DiseaseLiposarcoma, well differentiated

FASN NF1

5.16e-0461752C1370889
DiseaseLiposarcoma, Dedifferentiated

FASN NF1

5.16e-0461752C0205824
Diseaseneutropenia, response to metamizole, Drug-induced agranulocytosis

PTPRU EPHX4

5.16e-0461752EFO_0010971, HP_0012235, MONDO_0001475
Diseaseattention deficit hyperactivity disorder (implicated_via_orthology)

CHRNB2 SLC6A3 NF1

6.02e-04281753DOID:1094 (implicated_via_orthology)
DiseaseMalignant neoplasm of breast

FLT1 ERBB4 SRSF1 UBE2C ABCB6 PKDREJ NDUFS3 SLC6A3 FASN IGF1R NF1 PTPRD AKAP9 CSNK1D MMP14 TOP2A

6.95e-04107417516C0006142
Diseasefamilial hemiplegic migraine (implicated_via_orthology)

ATP12A ATP4A

7.20e-0471752DOID:0060178 (implicated_via_orthology)
DiseaseSubwakefullness Syndrome

CHRNB2 SLC6A3

7.20e-0471752C0751511
DiseaseSleep-Related Neurogenic Tachypnea

CHRNB2 SLC6A3

7.20e-0471752C0751510
DiseaseShort Sleeper Syndrome

CHRNB2 SLC6A3

7.20e-0471752C0751509
DiseaseLong Sleeper Syndrome

CHRNB2 SLC6A3

7.20e-0471752C0751508
DiseaseSleep Wake Disorders

CHRNB2 SLC6A3

7.20e-0471752C4042891
Diseasesyndromic X-linked intellectual disability Najm type (implicated_via_orthology)

CSNK1D CSNK1E

7.20e-0471752DOID:0060807 (implicated_via_orthology)
DiseaseHermansky-Pudlak syndrome (is_implicated_in)

HPS3 HPS5

7.20e-0471752DOID:3753 (is_implicated_in)
DiseaseSleep Disorders

CHRNB2 SLC6A3

7.20e-0471752C0851578
Diseasemelanoma

FLT1 ERBB4 ACER3 RET MTPAP FASN NF1

7.27e-042481757C0025202
DiseaseAmphetamine-Related Disorders

PDE6C RAPGEF5 SLC6A3 LARGE1

1.05e-03751754C0236733
DiseaseAmphetamine Abuse

PDE6C RAPGEF5 SLC6A3 LARGE1

1.05e-03751754C0236807
DiseaseAmphetamine Addiction

PDE6C RAPGEF5 SLC6A3 LARGE1

1.05e-03751754C0236804
Diseasenephroblastoma (is_marker_for)

FLT1 IGF1R TOP2A

1.07e-03341753DOID:2154 (is_marker_for)
Diseasenon-syndromic X-linked intellectual disability (implicated_via_orthology)

GDI1 DLG3

1.23e-0391752DOID:0050776 (implicated_via_orthology)
DiseaseHermanski-Pudlak Syndrome

HPS3 HPS5

1.53e-03101752C0079504
DiseaseShort Stature, CTCAE

EIF4A3 PUS7

1.53e-03101752C2919142
DiseaseShort stature

EIF4A3 PUS7

1.53e-03101752C0349588
DiseaseOptic Atrophy

NDUFS3 TBCD

1.53e-03101752C0029124
DiseaseHermansky-Pudlak syndrome

HPS3 HPS5

1.53e-03101752cv:C0079504
Diseaseplasma trimethylamine N-oxide measurement

FIG4 RHOBTB2

1.53e-03101752EFO_0005691
Diseaselong QT syndrome (implicated_via_orthology)

KCNH6 KCNH2

1.53e-03101752DOID:2843 (implicated_via_orthology)
Diseaseductal carcinoma in situ (is_marker_for)

FLT1 ERBB4 TOP2A

1.60e-03391753DOID:0060074 (is_marker_for)
Diseasepersonality trait

ASB17 ERBB4 PTPRD

1.60e-03391753EFO_0004365
DiseaseCutaneous Melanoma

ERBB4 RET NF1

1.85e-03411753C0151779
Diseasesleep disorder (implicated_via_orthology)

IGF1R NF1

1.86e-03111752DOID:535 (implicated_via_orthology)
DiseaseCongenital long QT syndrome

AKAP9 KCNH2

1.86e-03111752cv:C1141890
Diseasevisual epilepsy (is_implicated_in)

TBC1D24 CDKL5

1.86e-03111752DOID:11832 (is_implicated_in)
Diseaseplacenta growth factor measurement

FLT1 RAPGEF5

1.86e-03111752EFO_0010626
DiseaseLong QT Syndrome

RYR2 KCNH2

1.86e-03111752C0023976
Diseaseattention function measurement

ASB17 LAMC3 PTPRD NUAK1 RPS6KA6

1.94e-031481755EFO_0007636
Diseasecervix uteri carcinoma in situ (is_marker_for)

SRSF1 ADAM9 TOP2A

1.99e-03421753DOID:8991 (is_marker_for)
Diseaseautism spectrum disorder (implicated_via_orthology)

SHANK1 LAMC3 CHRNB2 SLC6A3 SHANK2

2.17e-031521755DOID:0060041 (implicated_via_orthology)
Diseasenervous system disease (implicated_via_orthology)

ATP12A ATP4A

2.22e-03121752DOID:863 (implicated_via_orthology)
DiseaseLong QT syndrome

AKAP9 KCNH2

2.22e-03121752cv:C0023976
Diseaseacute myeloid leukemia (implicated_via_orthology)

TOP2A TOP2B

2.22e-03121752DOID:9119 (implicated_via_orthology)
DiseaseAnxiety States, Neurotic

SHANK1 CHRNB2 SLC6A3

2.27e-03441753C0376280
DiseaseAnxiety neurosis (finding)

SHANK1 CHRNB2 SLC6A3

2.27e-03441753C1279420
DiseaseAnxiety Disorders

SHANK1 CHRNB2 SLC6A3

2.27e-03441753C0003469
DiseaseAdenocarcinoma of large intestine

ERBB4 RET PRKDC TAF1

2.60e-03961754C1319315
DiseaseRespiratory Depression

IGF1R TBCD

2.61e-03131752C0235063
DiseaseRespiratory Insufficiency

IGF1R TBCD

2.61e-03131752C0035229
DiseaseRespiratory Failure

IGF1R TBCD

2.61e-03131752C1145670
Diseaseoral cavity cancer

LAMC3 FAM227B

3.04e-03141752EFO_0005570
DiseaseKuhnt-Junius degeneration (is_marker_for)

FLT1 IGF1R

3.04e-03141752DOID:10873 (is_marker_for)
DiseaseHepatic fibrosis

ERBB4 ATP12A TNR

3.09e-03491753HP_0001395
Diseasebrain ischemia (biomarker_via_orthology)

RET CCR5 MMP14 HSPA9

3.23e-031021754DOID:2316 (biomarker_via_orthology)
DiseaseAganglionosis, Colonic

RET UTP25

3.49e-03151752C0085758
DiseaseOpioid use measurement

BEND4 PTPRD

3.49e-03151752EFO_0009937
Diseaseplatelet storage pool deficiency (implicated_via_orthology)

HPS3 HPS5

3.49e-03151752DOID:2223 (implicated_via_orthology)
DiseaseAganglionosis, Rectosigmoid Colon

RET UTP25

3.49e-03151752C1257840
Diseaseurinary bladder cancer (is_marker_for)

ERBB4 PLK1 SRSF9 TOP2A

3.84e-031071754DOID:11054 (is_marker_for)
DiseaseRomano-Ward Syndrome

AKAP9 KCNH2

3.97e-03161752C0035828
Diseasethyroid volume

FAM227B IGF1R

3.97e-03161752EFO_0004865
DiseasePheochromocytoma, Extra-Adrenal

RET NF1

3.97e-03161752C1257877
DiseasePeripheral Nervous System Diseases

MYO5A IGF1R RHOBTB2

4.07e-03541753C4721453
DiseaseMetastatic melanoma

CDKL5 PRKDC TAF1

4.07e-03541753C0278883
Diseaseleukemia

NF1 PLK1 TOP2A

4.29e-03551753C0023418
DiseaseAlzheimer's disease (is_marker_for)

NDUFS3 IGF1R CSNK1D CSNK1E CCR5 HSPA9

4.44e-032571756DOID:10652 (is_marker_for)
DiseaseCongenital Intestinal Aganglionosis

RET UTP25

4.49e-03171752C3661523
DiseaseBreast Carcinoma

FLT1 ERBB4 UBE2C NDUFS3 FASN IGF1R PTPRD MMP14 TOP2A

4.99e-035381759C0678222
DiseaseAdrenocortical carcinoma

IGF1R TOP2A

5.03e-03181752C0206686
Disease3-hydroxy-1-methylpropylmercapturic acid measurement

DOCK1 ARSG PTPRD CSNK1D RNASET2 PWWP3B TAF1

5.20e-033521757EFO_0007015
DiseaseMalignant neoplasm of skin

FLT1 ERBB4 IGF1R

5.23e-03591753C0007114
DiseaseSkin Neoplasms

FLT1 ERBB4 IGF1R

5.23e-03591753C0037286
Diseasecancer (implicated_via_orthology)

FLT1 RET GDI1 DLG3 TOP2A TOP2B

5.42e-032681756DOID:162 (implicated_via_orthology)
Diseasepulmonary non-tuberculous mycobacterial infection

FLT1 NUAK1

5.60e-03191752MONDO_0018469
DiseasePheochromocytoma

RET NF1

5.60e-03191752C0031511

Protein segments in the cluster

PeptideGeneStartEntry
GSIYKLLYREFIVFA

BEST3

26

Q8N1M1
VFLRKRYLVEDSLYP

ALG11

131

Q2TAA5
ETSSYRKLERYGEFL

FAM227B

111

Q96M60
RGTKLYEDRYALAIF

ERBB4

106

Q15303
EVQIVDYKYRELGFL

EOGT

396

Q5NDL2
DYKYRELGFLDQLRI

EOGT

401

Q5NDL2
YRRYADTLFDILVAG

BZW2

61

Q9Y6E2
RDGLEKRYIASYLAL

ACER3

56

Q9NUN7
FDLFYKRKAISRELY

BUD31

61

P41223
IYGKYLRAESFRKAL

AKAP9

3701

Q99996
SKRYLILIYSVEFDR

CCDC61

116

Q9Y6R9
VERLYRAAVTEGKLY

CLSTN3

146

Q9BQT9
LVAEEAHRKGYLRYV

ABCD2

281

Q9UBJ2
RYLIRFVFTTDELKY

BEND4

416

Q6ZU67
TLVTYIAFEKIRRDY

ADGRG2

646

Q8IZP9
LFYYRLLLVGIDEVK

AP4B1

516

Q9Y6B7
YEVERYREAIIKYQG

ABCB6

471

Q9NP58
QTVRLERYKAFYITG

ARSG

421

Q96EG1
KQTVFYLEDYLTVRR

PRMT8

336

Q9NR22
YLEDYLTVRRGEEIY

PRMT8

341

Q9NR22
DLVKELLFDAIGRYY

DEPDC7

296

Q96QD5
LDLVRRYFGEKIGLY

ANO4

336

Q32M45
SFRQYLEESLGKLRY

CCDC180

1021

Q9P1Z9
IYAFVGEKFRNYLLV

CCR5

296

P51681
YYKTGILERVDRRLV

ELF5

236

Q9UKW6
ARSIVEYREYIGGFK

EEPD1

61

Q7L9B9
GEYATYEAIRKAFRV

MMP14

136

P50281
LDSYYRTIKGFETLV

MTMR1

456

Q13613
YYKGRRVLEFRTLGD

OLFM2

236

O95897
RYDFRIYGLSTKRIA

OSMR

596

Q99650
LLGRSEYVEKFYRIK

RAD50

1276

Q92878
FLYGTEKVRLTYLRN

CDC42BPG

1366

Q6DT37
VYEFIYLVRDCGIRT

OOSP2

66

Q86WS3
YLIGDVYVERIIVRL

LTN1

786

O94822
RFYARYSLKSIDPVL

CCNC

71

P24863
EIIHRYVELLDKYFG

AP1S2

81

P56377
EYRKLLTVVVDAFYV

CFAP99

56

D6REC4
GEVAVLKRDGRYIYY

OARD1

66

Q9Y530
GIAIAYATLEYFIRD

MSH3

986

P20585
YLTFLEYDGNLLRRE

LARGE1

401

O95461
VTEEFVRRGYLIYKP

MAGEH1

136

Q9H213
LITEVFVRQKYLEYR

MAGEL2

1156

Q9UJ55
IFLEYVRYFRIKPLG

DOLK

371

Q9UPQ8
KGDYLKELFRRYGDI

RNGTT

166

O60942
VILDSLNYIKGFRYE

KTI12

76

Q96EK9
FLSYEELLQRRLGKY

ITIH5

156

Q86UX2
LFDKVRGYDIKLLRY

MTMR14

191

Q8NCE2
KEEEIRKYSIIYGRF

NAB2

291

Q15742
DLFVELKRYYVVGNV

GPC4

141

O75487
YQLREFKSEYRVVAL

EPHX4

111

Q8IUS5
FKSEYRVVALDLRGY

EPHX4

116

Q8IUS5
LVYESFLYRREKAAG

FLYWCH1

431

Q4VC44
GSFLVYESFLYRREK

FLYWCH1

516

Q4VC44
VYDEVRKLFIRLYPG

ATP12A

1016

P54707
LLTDYIAFVEKSGYR

ASB17

66

Q8WXJ9
YATRLYEKFGESALR

HPS5

851

Q9UPZ3
REDLLRGIYAYGFEK

EIF4A3

46

P38919
ARKLDRYSEYGAAVL

KCNH2

536

Q12809
VARKLDRYSEYGAAV

KCNH6

386

Q9H252
RLERLFYEKEYTGDR

LOXHD1

1366

Q8IVV2
ILLISKAEDYRSYRF

IGF1R

61

P08069
VERILGLLQTYFRKY

EID3

221

Q8N140
VGKRLDYITAEIKRY

PFDN6

76

O15212
YAISVARKIGARIYA

PLS1

586

Q14651
NIYIYLTAGKEVRRI

PLXNC1

436

O60486
DGREVNFYKIIDYIL

PDE6C

311

P51160
YIIDFGLAKKYRDAR

CSNK1D

146

P48730
YEDAGLRARTKIVYS

DPY19L1

576

Q2PZI1
YEARIQALEKELGRY

KIF7

1186

Q2M1P5
YDRFVLYKEGERDLR

LILRB2

251

Q8N423
ITLKDVFDDGRYVYL

RPS6KA6

481

Q9UK32
KTVIRRISAEAFYYL

LRIT3

66

Q3SXY7
YSLELRFRVEGQLYA

AP5B1

691

Q2VPB7
DKVIRFKRAIGYYSA

FAM120A

316

Q9NZB2
LYSLLRAKGERAYVV

PGAP4

366

Q9BRR3
RIIGLKDEFYNRYIT

PPP4R3B

596

Q5MIZ7
YIYGALDSRVRALVF

MTPAP

341

Q9NVV4
TFYATKRLIGRRYDD

HSPA9

116

P38646
AVLLYEYVGKRIVDL

NATD1

41

Q8N6N6
EEKRGITARELYSYL

CRNN

476

Q9UBG3
YLGRFYQDLKDRDVT

MANF

36

P55145
LSEKVVYRRFTEIYE

NCF1B

36

A6NI72
LSEKVVYRRFTEIYE

NCF1C

11

A8MVU1
VESLFYLYRVTGDRK

MAN1B1

601

Q9UKM7
IIVIIRKGRDHYAYS

PTPRU

766

Q92729
YSEVLTDTRGLYRKI

PRR7

166

Q8TB68
YYVSAEFRDKVRAGL

F2RL3

341

Q96RI0
SDYIKLYVRRVFITD

HSP90B1

406

P14625
FLRGKVFIYRGKEYE

DOCK1

1351

Q14185
IRRELYYFGVKVCII

SDR9C7

186

Q8NEX9
KLYIGDEATALDRYR

DUSP29

61

Q68J44
YYVLTRKFVEFILTD

GCNT7

281

Q6ZNI0
FLEGYYIVLITKRRK

FIG4

101

Q92562
YLSEGRYRLGDKILF

GAS2L3

236

Q86XJ1
GLKEVAIYILRRDYC

BTBD8

291

Q5XKL5
GKVIDEIYRVLRYVN

FBXO28

171

Q9NVF7
TIFAVGRYLEKYLER

A3GALT2

106

U3KPV4
GRYLEKYLERFLETA

A3GALT2

111

U3KPV4
TRYVELFIVVDKERY

ADAM9

211

Q13443
KRSLYVRALFDYDRT

DLG3

501

Q92796
FYVIERGTYDILVTK

PRKAR2A

176

P13861
VNRIKLYSESLARYG

GDI1

206

P31150
YEDSILAVRKYFQRI

IFNA8

136

P32881
TGLYEAYEAERRAKL

CCDC177

131

Q9NQR7
AQAEVYKELRLRGYD

FASN

986

P49327
RRGKLYLVFEYVEKN

CDKL5

81

O76039
TLTERVLYYTGRIAK

GFM1

61

Q96RP9
LEYIHARGLVYRDLK

SBK2

171

P0C263
KYGEFYGRDRISELL

RYR2

4656

Q92736
RKLGLEVYVTFFEIY

KIF2C

391

Q99661
YGILIFVYDEIRKLG

ATP4A

1006

P20648
VLEVYRGVREVLSKY

BYSL

181

Q13895
YRFETVQKLRFGIYD

CPNE1

66

Q99829
ASKIRSGYFDERYVL

CKMT1A

146

P12532
ERNGIITKYTLLYRD

PTPRD

946

P23468
LTYRLYDKFAEAVGV

ARHGAP30

106

Q7Z6I6
VLLVKAAAFSYYRGD

GPR132

261

Q9UNW8
LARYFYAISDIKVRG

NTNG1

281

Q9Y2I2
VYAQKGYLEELVRLR

RUNDC3A

261

Q59EK9
DLSIEEYIRVYKRLG

RARS2

246

Q5T160
RYTIKGIRNLIFYEL

UTP25

676

Q68CQ4
RRVFEKYGRVGDVYI

SRSF2

31

Q01130
DLYPSFLRKGYRREI

SLC6A6

416

P31641
EDLFYKYGRIREIEL

SRSF9

31

Q13242
YISFDILRRVLKDYF

CARS1

71

P49589
KEFFDLRLSYYGLRK

TOP2B

1041

Q02880
IRYLEAEFKKGNRYI

SMG5

906

Q9UPR3
KTRKIYDFLIREGYI

TADA2A

426

O75478
VFVDYGYQKRVLIED

TDRD15

831

B5MCY1
EDGLQKYERGLIFYI

HPS3

596

Q969F9
IAEQRVLRYGYFGKE

CMAS

256

Q8NFW8
LYERALKIYEDSLGR

NPHP3

1241

Q7Z494
GYRERELFDAKIIYE

PWWP3B

671

Q5H9M0
DFLIIRTRQGYYIRE

TAF1

761

P21675
TILKTLRYSRFFYDV

PKDREJ

2061

Q9NTG1
GYVELRYDDEVKRVV

NDUFS3

206

O75489
LLGSRYKKAVFREYT

HEPH

776

Q9BQS7
YRLEGFRKSEVAAYL

PSD4

596

Q8NDX1
FRAVLKYLYTGELDE

RHOBTB2

426

Q9BYZ6
EYLRALFVYEKGARV

RNF167

146

Q9H6Y7
RDYSLSGAYRKIIIR

PUS7

566

Q96PZ0
SGRIYVYRKDLADTL

RAPGEF5

311

Q92565
SKGELYDYISERRRL

NUAK1

136

O60285
RRVFEKYGRVGDVYI

SRSF8

31

Q9BRL6
VAVKELDLYLAYFVR

NFIC

171

P08651
EGVPSLEFRYKKRVY

SHANK2

131

Q9UPX8
EKGVPYLEFRYKTRV

SHANK1

146

Q9Y566
ISPRDFIDLVYIKRY

STARD6

106

P59095
YVDITYDFIIRRKPL

CHRNB2

221

P17787
TIRDGEVYYRSKYLR

BCO1

61

Q9HAY6
EIYRRLREFAKLYDT

CCDC146

506

Q8IYE0
ILVSIFAYDAFKIYR

CMTM5

196

Q96DZ9
DRELVKFIGDIYYGL

CLRN2

51

A0PK11
VFLVEGYKVLYRVAL

TBC1D24

231

Q9ULP9
QKKYFGRSLELYREL

RNASET2

131

O00584
IKIEFIGQIELYYDR

VPS26B

66

Q4G0F5
VADFLTYGRLQELYR

TRPM5

406

Q9NZQ8
LVMDELGYLYFRDRT

SLC27A4

491

Q6P1M0
LKRLERVIIGYLEVY

TTI2

381

Q6NXR4
YFIDRDGEIFRYVLS

KCTD15

101

Q96SI1
IDGIRAYLSVDFYRL

SLC6A3

291

Q01959
VEDSRNLYKLRIGSY

TNR

1246

Q92752
TFYVTLRYGRILDRE

TMEM186

186

Q96B77
YRKFRETTMYLIIGL

USP25

871

Q9UHP3
VREYTKYHERLLTGL

NF1

1686

P21359
FEISDRLIGIYKTYN

SMC4

1256

Q9NTJ3
LIRVSERIKGYALSY

SH2D4A

371

Q9H788
GKEYYIEILLQEYRL

PKHD1L1

456

Q86WI1
ISIDRYLIIKYPFRE

SUCNR1

116

Q9BXA5
AERLQYVFGYKLVEL

NSMCE3

131

Q96MG7
KLITEDFVRQRYLEY

NSMCE3

221

Q96MG7
RYKEVYAAAAEVLGL

PRKDC

2311

P78527
LAKLYRSIGEYDVLR

PRKDC

2926

P78527
LLIVEYAKYGSLRGF

RET

801

P07949
LDILRDFFELRLKYY

TOP2A

1016

P11388
YRLRVIAEAYATKGL

TTC7B

136

Q86TV6
YGKFLEEYTSQLRRI

WASHC4

31

Q2M389
DYLEFTDARGRKTRY

ZZEF1

1136

O43149
FYKYGAIRDIDLKNR

SRSF1

36

Q07955
LAFKFLYIITKVRGY

TBCD

101

Q9BTW9
ALEEGIVRYTKEVYV

MRPL27

91

Q9P0M9
ARYLTRGYSLIIKDV

FLT1

381

P17948
GLRLTDTFLKRTYEY

TRAPPC13

386

A5PLN9
LYTFGRIVIYIDRGV

TFIP11

801

Q9UBB9
GTVYEDLRYKLSLEF

UBE2C

71

O00762
KRDFRTYRLSLLEEY

PLK1

556

P53350
YIIDFGLAKKYRDAR

CSNK1E

146

P49674
TLRLGKAYEITYVRL

LAMC3

121

Q9Y6N6
LRFEKGRIYTYIGEV

MYO1G

31

B0I1T2
GKYIEIGFDKRYRII

MYO5A

221

Q9Y4I1