Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyBiologicalProcesscell morphogenesis involved in neuron differentiation

LRP1 MYCBP2 SULT4A1 KEL ERBB2 PLXNB1 LHX4

2.76e-06748197GO:0048667
GeneOntologyBiologicalProcessmotor neuron axon guidance

MYCBP2 ERBB2 LHX4

4.26e-0635193GO:0008045
GeneOntologyBiologicalProcessneuron projection morphogenesis

LRP1 MYCBP2 SULT4A1 KEL ERBB2 PLXNB1 LHX4

4.38e-06802197GO:0048812
GeneOntologyBiologicalProcessplasma membrane bounded cell projection morphogenesis

LRP1 MYCBP2 SULT4A1 KEL ERBB2 PLXNB1 LHX4

5.03e-06819197GO:0120039
GeneOntologyBiologicalProcesscell projection morphogenesis

LRP1 MYCBP2 SULT4A1 KEL ERBB2 PLXNB1 LHX4

5.32e-06826197GO:0048858
GeneOntologyBiologicalProcessaxonogenesis

LRP1 MYCBP2 KEL ERBB2 PLXNB1 LHX4

8.32e-06566196GO:0007409
GeneOntologyBiologicalProcessaxon development

LRP1 MYCBP2 KEL ERBB2 PLXNB1 LHX4

1.70e-05642196GO:0061564
GeneOntologyBiologicalProcesscell morphogenesis

LRP1 MYCBP2 SULT4A1 KEL ERBB2 PLXNB1 LHX4

5.82e-051194197GO:0000902
GeneOntologyBiologicalProcessneuron projection development

LRP1 MYCBP2 SULT4A1 KEL ERBB2 PLXNB1 LHX4

9.29e-051285197GO:0031175
GeneOntologyBiologicalProcessaxon guidance

LRP1 MYCBP2 ERBB2 LHX4

1.17e-04285194GO:0007411
GeneOntologyBiologicalProcessneuron projection guidance

LRP1 MYCBP2 ERBB2 LHX4

1.19e-04286194GO:0097485
GeneOntologyBiologicalProcessneuron development

LRP1 MYCBP2 SULT4A1 KEL ERBB2 PLXNB1 LHX4

2.10e-041463197GO:0048666
GeneOntologyBiologicalProcesspositive regulation of Rho protein signal transduction

ERBB2 PLXNB1

6.45e-0441192GO:0035025
GeneOntologyBiologicalProcessregulation of axonogenesis

LRP1 KEL PLXNB1

6.89e-04192193GO:0050770
GeneOntologyBiologicalProcessplacenta development

TRIM28 FBN2 LHX4

7.43e-04197193GO:0001890
GeneOntologyBiologicalProcesssemaphorin-plexin signaling pathway

ERBB2 PLXNB1

1.04e-0352192GO:0071526
GeneOntologyCellularComponentsemaphorin receptor complex

ERBB2 PLXNB1

6.74e-0513202GO:0002116
MousePhenoabnormal interdigital cell death

FRAS1 FBN2

1.39e-055172MP:0009874
DomainGrowth_fac_rcpt_

LRP1 ERBB2 FRAS1 FBN2

1.65e-05156194IPR009030
DomainFurin_repeat

ERBB2 FRAS1

1.49e-0418192IPR006212
DomainFU

ERBB2 FRAS1

1.49e-0418192SM00261
DomaincEGF

LRP1 FBN2

3.14e-0426192IPR026823
DomaincEGF

LRP1 FBN2

3.14e-0426192PF12662
Domain-

MYCBP2 TRIM28 LONRF1 INTS12

9.59e-044491943.30.40.10
DomainZnf_RING/FYVE/PHD

MYCBP2 TRIM28 LONRF1 INTS12

1.04e-03459194IPR013083
DomainEGF

LRP1 FRAS1 FBN2

1.64e-03235193SM00181
DomainEGF-like_dom

LRP1 FRAS1 FBN2

1.94e-03249193IPR000742
DomainZinc_finger_PHD-type_CS

TRIM28 INTS12

1.96e-0365192IPR019786
DomainPHD

TRIM28 INTS12

2.60e-0375192PF00628
DomainZnf_PHD-finger

TRIM28 INTS12

2.88e-0379192IPR019787
DomainZF_BBOX

MYCBP2 TRIM28

2.96e-0380192PS50119
DomainZF_RING_1

MYCBP2 TRIM28 LONRF1

3.01e-03291193PS00518
DomainZnf_B-box

MYCBP2 TRIM28

3.03e-0381192IPR000315
DomainZF_RING_2

MYCBP2 TRIM28 LONRF1

3.22e-03298193PS50089
DomainEGF_CA

LRP1 FBN2

3.41e-0386192PF07645
DomainRING

MYCBP2 TRIM28 LONRF1

3.44e-03305193SM00184
DomainPHD

TRIM28 INTS12

3.64e-0389192SM00249
DomainZnf_PHD

TRIM28 INTS12

3.80e-0391192IPR001965
DomainZF_PHD_2

TRIM28 INTS12

4.14e-0395192PS50016
DomainZnf_RING

MYCBP2 TRIM28 LONRF1

4.15e-03326193IPR001841
DomainZF_PHD_1

TRIM28 INTS12

4.22e-0396192PS01359
DomainEGF_Ca-bd_CS

LRP1 FBN2

4.31e-0397192IPR018097
DomainEGF_CA

LRP1 FBN2

4.48e-0399192PS01187
DomainASX_HYDROXYL

LRP1 FBN2

4.57e-03100192PS00010
DomainIg_E-set

MYCBP2 PLXNB1

4.94e-03104192IPR014756
DomainEGF-type_Asp/Asn_hydroxyl_site

LRP1 FBN2

5.12e-03106192IPR000152
DomainEGF_CA

LRP1 FBN2

6.73e-03122192SM00179
DomainEGF-like_Ca-bd_dom

LRP1 FBN2

6.94e-03124192IPR001881
DomainZnf_FYVE_PHD

TRIM28 INTS12

9.64e-03147192IPR011011
PathwayREACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE

ERBB2 PLXNB1

6.60e-0511162MM15046
PathwayREACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING

ERBB2 PLXNB1

1.26e-0415162MM15037
PathwayREACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE

ERBB2 PLXNB1

2.27e-0420162M18415
PathwayREACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING

ERBB2 PLXNB1

3.29e-0424162M2243
Pubmed

ErbB-2 signals through Plexin-B1 to promote breast cancer metastasis.

ERBB2 PLXNB1

3.14e-07220222378040
Pubmed

Plexin-B1/RhoGEF-mediated RhoA activation involves the receptor tyrosine kinase ErbB-2.

ERBB2 PLXNB1

3.14e-07220215210733
Pubmed

ErbB-2 and met reciprocally regulate cellular signaling via plexin-B1.

ERBB2 PLXNB1

1.88e-06420218025083
Pubmed

Secreted heat shock protein 90alpha induces colorectal cancer cell invasion through CD91/LRP-1 and NF-kappaB-mediated integrin alphaV expression.

LRP1 ERBB2

1.88e-06420220558745
Pubmed

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.

LRP1 MYCBP2 TRIM28 ERBB2 FRAS1 PLXNB1 FBN2

3.01e-06120120735696571
Pubmed

Suppression of bone formation by osteoclastic expression of semaphorin 4D.

ERBB2 PLXNB1

6.59e-06720222019888
Pubmed

Discovery of candidate disease genes in ENU-induced mouse mutants by large-scale sequencing, including a splice-site mutation in nucleoredoxin.

ERBB2 MED13

1.13e-05920220011118
Pubmed

The ubiquitin ligase Uhrf2 is a master regulator of cholesterol biosynthesis and is essential for liver regeneration.

ZNF638 TRIM28 INTS12

1.61e-058620337253089
Pubmed

Evidence for new homotypic and heterotypic interactions between transmembrane helices of proteins involved in receptor tyrosine kinase and neuropilin signaling.

ERBB2 PLXNB1

1.72e-051120225315821
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

MYCBP2 TRIM28 LONRF1 ERBB2 FRAS1 MED13

2.68e-05110520635748872
Pubmed

FBXO45-MYCBP2 regulates mitotic cell fate by targeting FBXW7 for degradation.

MYCBP2 MED13

3.28e-051520231285543
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

TMEM222 LRP1 MYCBP2 SULT4A1 LONRF1 MED13

6.24e-05128520635914814
Pubmed

Sema4C-Plexin B2 signalling modulates ureteric branching in developing kidney.

ERBB2 PLXNB1

7.89e-052320221035938
Pubmed

Functional genetic analysis of mouse chromosome 11.

ERBB2 MED13

7.89e-052320212955145
Pubmed

Analysis of Ku70 S155 Phospho-Specific BioID2 Interactome Identifies Ku Association with TRIP12 in Response to DNA Damage.

ZNF638 TRIM28 INTS12

9.54e-0515620337108203
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

TESMIN ZDHHC14 LRP1 ZNF638 MYCBP2 ERBB2

1.41e-04148920628611215
Pubmed

Biochemical Reduction of the Topology of the Diverse WDR76 Protein Interactome.

LRP1 FRAS1 FBN2

2.59e-0421920331353912
Pubmed

A non-proteolytic role for ubiquitin in deadenylation of MHC-I mRNA by the RNA-binding E3-ligase MEX-3C.

MYCBP2 TRIM28

2.93e-044420226471122
Pubmed

Interactome analyses revealed that the U1 snRNP machinery overlaps extensively with the RNAP II machinery and contains multiple ALS/SMA-causative proteins.

ZNF638 TRIM28 INTS12

3.56e-0424420329884807
Pubmed

Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.

ZNF638 FRAS1 PLXNB1 TUBGCP4

4.62e-0465020438777146
Pubmed

Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function.

LRP1 INTS12

5.09e-045820223284291
GeneFamilyPHD finger proteins

TRIM28 INTS12

1.57e-039012288
GeneFamilyADAM metallopeptidase domain containing|CD molecules

LRP1 KEL ERBB2

1.95e-03394123471
GeneFamilyRing finger proteins

TRIM28 LONRF1

1.38e-0227512258
CoexpressionGSE22611_NOD2_VS_MUTANT_NOD2_TRANSDUCED_HEK293T_CELL_UP

ZDHHC14 TRIM28 SPATA2L MED13 TUBGCP4

3.39e-07199205M8164
ToppCellControl_saline-Epithelial_alveolar-AT_1-Differentiating_AT1|Control_saline / Treatment groups by lineage, cell group, cell type

ERBB2 FRAS1 PLXNB1 FBN2

1.67e-0619820485f424cd9bb3117c9e322031024aabb87696ce47
ToppCellChildren_(3_yrs)-Epithelial-basal_cell-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

KEL FRAS1 PLXNB1

4.55e-051572036ee2692f705bdd93ba523dffaf2f0cd921b47e28
ToppCellrenal_cortex_nuclei-Adult_normal_reference|renal_cortex_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group

ZNF638 LONRF1 FRAS1

7.89e-05189203a48df46274d51e84ffb40264646de7346104efb9
ToppCellhuman_hepatoblastoma-Tumor_cells|World / Sample and Cell Type and Tumor Cluster (all cells)

ZNF638 FRAS1 MED13

8.27e-05192203916fbec1c7ab7969bda711886ac88e877e30c280
ToppCellhuman_hepatoblastoma|World / Sample and Cell Type and Tumor Cluster (all cells)

ZNF638 FRAS1 MED13

8.40e-05193203e6a688bc834f845ff64dae1be64f073eec5091a1
ToppCellLPS_IL1RA-Epithelial_alveolar-AT_1-Differentiating_AT1|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

ERBB2 FRAS1 PLXNB1

9.06e-05198203b598ab958e31f1e98bd06dc0097b58ac3a3f90a3
ToppCellControl_saline-Epithelial_alveolar-AT_1|Control_saline / Treatment groups by lineage, cell group, cell type

ERBB2 FRAS1 FBN2

9.06e-051982039b161285df7a4e51618f3517cfc5b8221ba55786
ToppCellLPS_anti-TNF-Epithelial_alveolar-AT_1-Differentiating_AT1|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

ERBB2 FRAS1 PLXNB1

9.19e-05199203d43c605a4ff221cf78d91678c15d2ad20f831c7f
ToppCellLPS_IL1RA_TNF-Epithelial_alveolar-AT_1|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

ERBB2 FRAS1 PLXNB1

9.19e-051992031c70e7d6bd25980e1b92aa1cac3f3c95d9651b4b
ToppCellLPS_IL1RA-Epithelial_alveolar-AT_1|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

ERBB2 FRAS1 PLXNB1

9.19e-05199203a270630626df614f8605abddb7dee7c4d74f6149
ToppCellLPS_IL1RA_TNF-Epithelial_alveolar-AT_1-Differentiating_AT1|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

ERBB2 FRAS1 PLXNB1

9.33e-05200203ddfb1f006365bf16203ee49f20200f68220cc288
ToppCellLPS_anti-TNF-Epithelial_alveolar-AT_1|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

ERBB2 FRAS1 PLXNB1

9.33e-052002038683445ad5b70748c4a1f12eb77d47623085147e
DrugRemoxipride Hydrochloride [73220-03-8]; Up 200; 9.8uM; HL60; HT_HG-U133A

ZDHHC14 SULT4A1 SPATA2L KEL

2.27e-051952043124_UP
DrugTinidazole [19387-91-8]; Up 200; 16.2uM; MCF7; HT_HG-U133A

TESMIN ZDHHC14 SPATA2L PLXNB1

2.32e-051962043896_UP
DrugMethimazole [60-56-0]; Up 200; 35uM; MCF7; HT_HG-U133A

TESMIN SULT4A1 ERBB2 FRAS1

2.32e-051962044372_UP
Diseasecardiomyopathy (implicated_via_orthology)

LRP1 ERBB2

1.05e-0371202DOID:0050700 (implicated_via_orthology)

Protein segments in the cluster

PeptideGeneStartEntry
DCLACLHFNHSGICE

ERBB2

251

P04626
LVECQECHNLYHRDC

INTS12

176

Q96CB8
CADCHHLCQHCAADL

FRAS1

806

Q86XX4
DLCLLTHQGHVNCSC

LRP1

2491

Q07954
HSFCKNCLERCLDHA

LONRF1

496

Q17RB8
SCAQHLDCASCLAHR

PLXNB1

481

O43157
HLHCFACIICNRQLA

LHX4

111

Q969G2
HCLNEILDLCHSFCS

TUBGCP4

581

Q9UGJ1
DLDRCCLSHHCCLEQ

OC90

341

Q02509
DICKHHANLCLNGRC

FBN2

496

P35556
NCNNCCNNLHHDIER

TESMIN

321

Q9Y4I5
CDTCRQLHAAHCAAL

SPATA2L

371

Q8IUW3
AIQLDCSHIFHLQCC

MYCBP2

4441

O75592
SLEDCHCNLFCLADL

MED13

11

Q9UHV7
LTEHCHQLVDQCCNA

SULT4A1

226

Q9BR01
CSLCDNCVERFDHHC

ZDHHC14

181

Q8IZN3
MHNLCCDNCHSHVAL

TMEM222

136

Q9H0R3
HLCSLCNVECSHLKD

ZNF638

426

Q14966
NQCEFCFHLDCHLPA

TRIM28

641

Q13263
CLACDNHALQEAHLC

KEL

596

P23276