Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	Myb-like_dom	DMTF1 SNAPC4	1.51e-04	6	60	2	IPR017877
Domain	HTH_MYB	DMTF1 SNAPC4	3.60e-04	9	60	2	PS51294
Domain	Myb_dom	DMTF1 SNAPC4	3.60e-04	9	60	2	IPR017930
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	FMNL3 ZFYVE28 RALGDS TET1 HECTD4 TNKS1BP1 NACAD PLXNB1 WNK2	4.65e-07	529	63	9	14621295
Pubmed	Duplicated zinc finger protein genes on the proximal short arm of the human X chromosome: isolation, characterization and X-inactivation studies.	ZXDA ZXDB	3.23e-06	2	63	2	8268913
Pubmed	Identification of novel Ack1-interacting proteins and Ack1 phosphorylated sites in mouse brain by mass spectrometry.	MAP4 HNRNPUL2 AJM1 GPRIN1	6.88e-06	67	63	4	29254152
Pubmed	Hsp90 regulates p50(cdc37) function during the biogenesis of the activeconformation of the heme-regulated eIF2 alpha kinase.	EIF2AK1 HSP90AB1	1.93e-05	4	63	2	11036079
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	NISCH HECTD4 PER1 TNKS1BP1 ZNF395 STK32C SNAPC4 ZBED3 WNK2 RYR1	2.79e-05	1105	63	10	35748872
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	MAP4 HNRNPUL2 AJM1 PER1 PAK3 GPRIN1 PCDH8 NACAD WNK2 HSP90AB1	3.60e-05	1139	63	10	36417873
Pubmed	Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	TET1 ZFHX2 TNKS1BP1 WNK2	3.64e-05	102	63	4	11214970
Pubmed	Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.	MAP4 AJM1 TNKS1BP1 GPRIN1 ADD1 HSP90AB1	3.98e-05	347	63	6	17114649
Pubmed	Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition.	RNF19B STK32C EIF2AK1 FBXO27 MAP3K6 HSP90AB1	5.85e-05	372	63	6	22939624
Pubmed	Identification of a tankyrase-binding motif shared by IRAP, TAB182, and human TRF1 but not mouse TRF1. NuMA contains this RXXPDG motif and is a novel tankyrase partner.	TNKS1BP1 PPP1R12C	1.15e-04	9	63	2	12080061
Pubmed	A census of human transcription factors: function, expression and evolution.	DMTF1 ZNF274 ZFHX2 CAMTA2 ZNF395 MESP1 SNAPC4 ZBED3	2.28e-04	908	63	8	19274049
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	MAP4 HNRNPUL2 AJM1 NISCH TNKS1BP1 ARHGEF17 WNK2 ADD1 PPP1R12C HSP90AB1	2.36e-04	1431	63	10	37142655
Pubmed	A probability-based approach for high-throughput protein phosphorylation analysis and site localization.	MAP4 HNRNPUL2 TNKS1BP1 POLR1G ZXDA HSP90AB1	3.00e-04	503	63	6	16964243
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	HNRNPUL2 NISCH HECTD4 PAK3 PCDH8 WNK2 ADD1 HSP90AB1	3.38e-04	963	63	8	28671696
Pubmed	Structural basis and sequence rules for substrate recognition by Tankyrase explain the basis for cherubism disease.	TNKS1BP1 PPP1R12C	4.32e-04	17	63	2	22153077
Pubmed	Phosphoproteomic analysis of synaptosomes from human cerebral cortex.	ADD1 HSP90AB1	4.32e-04	17	63	2	15822905
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	MAP4 TNKS1BP1 SNAPC4 POLR1G GPRIN1 ADD1 HSP90AB1	4.94e-04	774	63	7	15302935
Pubmed	Comprehensive Target Screening and Cellular Profiling of the Cancer-Active Compound b-AP15 Indicate Abrogation of Protein Homeostasis and Organelle Dysfunction as the Primary Mechanism of Action.	PSMA1 ASPSCR1 HSP90AB1	6.34e-04	92	63	3	35530310
Pubmed	EEF1D Promotes Glioma Proliferation, Migration, and Invasion through EMT and PI3K/Akt Pathway.	HNRNPUL2 TNKS1BP1	6.63e-04	21	63	2	33029523
Pubmed	Genome-wide association study in Chinese identifies novel loci for blood pressure and hypertension.	HECTD4 TNXB	6.63e-04	21	63	2	25249183
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	MAP4 TET1 TNKS1BP1 STK32C ARHGEF17 MAP3K6 PPP1R12C	9.23e-04	861	63	7	36931259
Pubmed	A directed protein interaction network for investigating intracellular signal transduction.	TCF19 MAP4 ASPSCR1 SNAPC4 PCDH8 NACAD ADD1 HSP90AB1	9.31e-04	1124	63	8	21900206
Pubmed	BCAR1 promotes proliferation and cell growth in lung adenocarcinoma via upregulation of POLR2A.	NISCH PER1 BIRC7 WNK2 PPP1R12C	9.82e-04	419	63	5	33001583
Pubmed	Phosphoproteomic analysis of the developing mouse brain.	MAP4 TNKS1BP1 POLR1G ADD1	1.05e-03	246	63	4	15345747
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	RALGDS HNRNPUL2 NISCH MAP3K6 PLXNB1 ZXDB	1.15e-03	650	63	6	38777146
Pubmed	Global gene expression analysis of murine limb development.	DMTF1 TCF19 ZNF274	1.27e-03	117	63	3	22174793
Pubmed	The tissue-specific transcriptomic landscape of the mid-gestational mouse embryo.	POLR1G ADD1	1.36e-03	30	63	2	24803591
Pubmed	FBXO38 Ubiquitin Ligase Controls Centromere Integrity via ZXDA/B Stability.	ZXDA ZXDB	1.55e-03	32	63	2	35813202
Pubmed	Primary Ciliary Dyskinesia	DNAAF3 MCIDAS	1.55e-03	32	63	2	20301301
Pubmed	mTORC1 activity regulates post-translational modifications of glycine decarboxylase to modulate glycine metabolism and tumorigenesis.	MAP4 HNRNPUL2 ADD1 HSP90AB1	1.56e-03	274	63	4	34244482
Pubmed	Proteomic analysis reveals novel binding partners of MIP-T3 in human cells.	MAP4 HSP90AB1	1.75e-03	34	63	2	20391533
Cytoband	9q34.3	RALGDS AJM1 SNAPC4	4.30e-04	106	63	3	9q34.3
Disease	response to acetylsalicylate	DNAAF3 MAP4	4.32e-04	16	57	2	GO_1903492
Disease	congestive heart failure (is_implicated_in)	NISCH RYR1	1.25e-03	27	57	2	DOID:6000 (is_implicated_in)
Disease	Polynesian Bronchiectasis	DNAAF3 MCIDAS	2.09e-03	35	57	2	C4317124
Disease	Ciliary Dyskinesia, Primary, 1, With Or Without Situs Inversus	DNAAF3 MCIDAS	2.09e-03	35	57	2	C4551906
Disease	Kartagener Syndrome	DNAAF3 MCIDAS	2.09e-03	35	57	2	C0022521
Disease	soluble triggering receptor expressed on myeloid cells 2 measurement	DNAAF3 GDAP1L1 VSTM2B STK32C	2.58e-03	296	57	4	EFO_0010151
Disease	attention deficit hyperactivity disorder, conduct disorder	KIAA2012 PGBD5	2.73e-03	40	57	2	EFO_0003888, EFO_0004216
Disease	cups of coffee per day measurement	HECTD4 ADD1	2.73e-03	40	57	2	EFO_0006782
Disease	Primary Ciliary Dyskinesia	DNAAF3 MCIDAS	3.75e-03	47	57	2	C4551720

Protein segments in the cluster

Peptide	Gene	Start	Entry
APDPAPKSEPAAEEG	ASPSCR1	506	Q9BZE9
EPAAPGEAADASPEP	AJM1	641	C9J069
PALPPASDDGAAPED	CAMTA2	911	O94983
EEPEDAAPVAPSVPA	BIRC7	181	Q96CA5
PEPPDALEADTFPDE	DMTF1	601	Q9Y222
KPAEAPDAPEAASPA	GDAP1L1	26	Q96MZ0
APERQEEAPPPSEDA	ZFYVE28	606	Q9HCC9
PSAEAKPPEAARPAD	ARHGEF17	1036	Q96PE2
PEPPAAVDFLEPDSG	FCHO1	301	O14526
ASEPPLAPPVSEEED	PAK3	176	O75914
AAEEPNAAVPDEIPP	HSP90AB1	696	P08238
PPAGEEPAISEAAPE	MAP4	1101	P27816
EPFPAPPEDDAATAK	KATNB1	401	Q9BVA0
LRVPEEPAAEEPASP	MAP3K6	971	O95382
PPPSAEAAEPEARLA	PER1	1011	O15534
EVAAVPPADPGPEAL	PLXNB1	796	O43157
AADAPPPAVAAAEVP	PCDH8	836	O95206
PEPPEAAAMEAAAEP	HNRNPUL2	111	Q1KMD3
GDDDAPPHDVAPPLD	KIAA2012	526	Q0VF49
PAQPADEPAEKADEP	PSMA1	246	P25786
PHPPPIADDESDDDD	HECTD4	2226	Q9Y4D8
EDPPDAEPTALPALT	MCIDAS	61	D6RGH6
VEPAAEEPSPAEPAT	PRR27	186	Q6MZM9
EEPSPAEPATAKPAA	PRR27	191	Q6MZM9
PPRAPDAQEPEEDEA	PGBD5	76	Q8N414
ETLVEPPEPCAEPAA	FKBP11	41	Q9NYL4
PALDLQAESPPVDPD	DNAAF3	21	Q8N9W5
VAAPPAIDFPAEGPD	EIF2AK1	21	Q9BQI3
SDLDLLAPAPPPEEV	FMNL3	501	Q8IVF7
GREEEAPPEAAAVPP	CERKL	16	Q49MI3
ESAPAPALELEPAPE	RALGDS	326	Q12967
ALAAAVAPPEPAEPV	GPRIN1	896	Q7Z2K8
ARVPAPEPEPEEALD	FBXO27	11	Q8NI29
PTDAPAADEPPSELV	B3GNT6	51	Q6ZMB0
PPAEDEARAAEPDPD	RYR1	1316	P21817
PEAEAADDFPPRPEV	KIF17	661	Q9P2E2
EIAPLEPDAPPDACE	MMP11	281	P24347
PPEALPAEPAAEAEA	RNF19B	76	Q6ZMZ0
ELDPAAPPPARAVLD	PPP1R12C	81	Q9BZL4
PELPDDLEPQAAPTS	POLR1G	406	O15446
ARDEEDPEPPVAAPD	SYCE1L	226	A8MT33
PRDPPALFAEAACPE	MESP1	216	Q9BRJ9
RPAAEDLPEPVPNCA	STRC	1451	Q7RTU9
PLPAPESRDAAEPVE	STK32C	451	Q86UX6
ADEPPSDEPLSDDPL	TET1	1966	Q8NFU7
EASPEPAPDPAPVAE	ADD1	676	P35611
APADTTEAADVPPPV	C11orf42	241	Q8N5U0
LAELDDESEPPENPP	TCF19	231	Q9Y242
AAPPPLKDDPEGDRD	ZBED3	211	Q96IU2
PAPAPEEEAEGPAAA	ZXDB	241	P98169
APSPVPEPDAQAEDV	ZFHX2	1126	Q9C0A1
EAPPGEAPPKEDLSE	ROM1	336	Q03395
SPPAAIDPAVPEAAA	VSTM2B	206	A6NLU5
ELAPNSDIPEEEPAP	ZNF274	336	Q96GC6
APDQPCVLFADAPEP	TNKS1BP1	626	Q9C0C2
APEEDTPAPELAPEA	TNXB	3536	P22105
VPAEALAPAPAEVPA	NISCH	1046	Q9Y2I1
ETDPDPFLLDEPAPR	ZNF395	256	Q9H8N7
DLLLAEPAEPAPAPA	ZXDA	226	P98168
LPSEDLDPADPPISE	SNAPC4	46	Q5SXM2
EEAAPDPAAAPEDPT	TLDC2	31	A0PJX2
PDPIAAAVETAPAPD	WNK2	126	Q9Y3S1
LDPDAEAPGSEPQDP	ZNF358	71	Q9NW07
REVPDAPPAACPEVS	NACAD	1101	O15069