Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionoxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor

GLUD1 GLUD2

9.78e-0521982GO:0016639
GeneOntologyMolecularFunctionglutamate dehydrogenase [NAD(P)+] activity

GLUD1 GLUD2

9.78e-0521982GO:0004353
GeneOntologyMolecularFunctionglutamate dehydrogenase (NAD+) activity

GLUD1 GLUD2

9.78e-0521982GO:0004352
GeneOntologyMolecularFunctionglutamate dehydrogenase (NADP+) activity

GLUD1 GLUD2

9.78e-0521982GO:0004354
GeneOntologyMolecularFunctionhistone reader activity

ZZEF1 USP15 HDGFL2 ZZZ3

1.18e-04261984GO:0140566
GeneOntologyMolecularFunctionclathrin binding

EPN1 EPN3 BIN1 EPN2 CLINT1

4.02e-04631985GO:0030276
GeneOntologyMolecularFunctionATP-dependent activity

ACSS1 DDX1 DDX46 ACSM3 RAD54L HSP90AB1 RBBP4 ATP13A1 SMCHD1 DNAH2 MORC2 DNAH12 ERCC6L2 MACF1 KIF18B AQR

4.29e-0461419816GO:0140657
GeneOntologyMolecularFunctionpropionate-CoA ligase activity

ACSS1 ACSM3

5.79e-0441982GO:0050218
GeneOntologyMolecularFunctionshort-chain fatty acid-CoA ligase activity

ACSS1 ACSM3

5.79e-0441982GO:0031955
GeneOntologyMolecularFunctionchromatin-protein adaptor activity

ZZEF1 USP15 HDGFL2 ZZZ3

7.13e-04411984GO:0140463
DomainENTH

EPN1 EPN3 EPN2 CLINT1

1.81e-0761984PF01417
DomainENTH

EPN1 EPN3 EPN2 CLINT1

1.48e-0691984PS50942
DomainENTH

EPN1 EPN3 EPN2 CLINT1

1.48e-0691984SM00273
DomainENTH

EPN1 EPN3 EPN2 CLINT1

2.45e-06101984IPR013809
DomainG2F

HMCN2 NID2 HMCN1

4.66e-0641983PF07474
DomainNIDOGEN_G2

HMCN2 NID2 HMCN1

4.66e-0641983PS50993
DomainGFP

HMCN2 NID2 HMCN1

4.66e-0641983IPR009017
DomainG2_nidogen/fibulin_G2F

HMCN2 NID2 HMCN1

4.66e-0641983IPR006605
DomainUIM

EPN1 EPN3 USP37 EPN2

3.34e-05181984PF02809
Domain-

SACS HSP90AB1 SMCHD1 MORC2

5.20e-052019843.30.565.10
DomainUIM

EPN1 EPN3 USP37 EPN2

6.37e-05211984SM00726
DomainHATPase_C

SACS HSP90AB1 SMCHD1 MORC2

6.37e-05211984IPR003594
DomainUIM

EPN1 EPN3 USP37 EPN2

1.10e-04241984PS50330
DomainELFV_dehydrog_N

GLUD1 GLUD2

1.12e-0421982PF02812
DomainGlu/Leu/Phe/Val_DH_C

GLUD1 GLUD2

1.12e-0421982IPR006096
DomainGlu/Leu/Phe/Val_DH_dimer_dom

GLUD1 GLUD2

1.12e-0421982IPR006097
DomainGlu/Leu/Phe/Val_DH

GLUD1 GLUD2

1.12e-0421982IPR006095
DomainELFV_dehydrog

GLUD1 GLUD2

1.12e-0421982PF00208
DomainNAD_bind_Glu_DH

GLUD1 GLUD2

1.12e-0421982IPR033922
DomainGLFV_DEHYDROGENASE

GLUD1 GLUD2

1.12e-0421982PS00074
DomainELFV_dehydrog

GLUD1 GLUD2

1.12e-0421982SM00839
DomainGlu/Leu/Phe/Val_DH_AS

GLUD1 GLUD2

1.12e-0421982IPR033524
DomainAKAP2_C

MISP3 MISP

1.12e-0421982PF15304
DomainAKAP2_C

MISP3 MISP

1.12e-0421982IPR029304
DomainUIM_dom

EPN1 EPN3 USP37 EPN2

1.30e-04251984IPR003903
DomainWW

WWOX APBB3 NEDD4 MAGI2 PRPF40B

1.36e-04471985PF00397
DomainWW

WWOX APBB3 NEDD4 MAGI2 PRPF40B

1.51e-04481985SM00456
Domain-

EPN1 EPN3 EPN2 CLINT1

1.53e-042619841.25.40.90
DomainWW_DOMAIN_1

WWOX APBB3 NEDD4 MAGI2 PRPF40B

2.01e-04511985PS01159
DomainWW_DOMAIN_2

WWOX APBB3 NEDD4 MAGI2 PRPF40B

2.01e-04511985PS50020
DomainWW_dom

WWOX APBB3 NEDD4 MAGI2 PRPF40B

2.21e-04521985IPR001202
DomainENTH_VHS

EPN1 EPN3 EPN2 CLINT1

2.36e-04291984IPR008942
DomainG2F

NID2 HMCN1

3.33e-0431982SM00682
DomainFN3_dom

IL10RB PRTG MYLK KIAA0319 FLRT2 USH2A EPHA5 IL9R MYBPC2

4.02e-042091989IPR003961
Domain-

GPRASP1 DNAJC13 PKP4 HEATR5A ECPAS CSE1L SF3B1 CTNND2 TNPO3

6.21e-0422219891.25.10.10
DomainARM-like

GPRASP1 GPRASP2 DNAJC13 PKP4 HEATR5A ECPAS CSE1L SF3B1 CTNND2 TNPO3

6.33e-0427019810IPR011989
DomainFN3

IL10RB PRTG MYLK KIAA0319 FLRT2 USH2A EPHA5 MYBPC2

8.18e-041851988SM00060
DomainFN3

IL10RB PRTG MYLK FLRT2 USH2A EPHA5 IL9R MYBPC2

1.31e-031991988PS50853
DomainFF_domain

PRPF40B ARHGAP5

1.63e-0361982IPR002713
DomainFF

PRPF40B ARHGAP5

1.63e-0361982PS51676
DomainFF

PRPF40B ARHGAP5

1.63e-0361982PF01846
DomainFF

PRPF40B ARHGAP5

1.63e-0361982SM00441
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

GPRASP1 PPP1R12A LMTK3 NEDD4 KIAA0319 MAGI2 PRRC2C SVIL HSP90AB1 BIN1 DNAJC13 NYAP2 SLC4A8 TCF20 PKP4 PPP1R9A CCDC88A SF3B1 DGKI MACF1 EML1 CTNND2 CNOT1

1.29e-089632032328671696
Pubmed

Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.

WWOX BCORL1 C15orf39 ALMS1 BRCA2 GPRASP2 SAMD1 DNAJC13 TCF20 ECPAS KIAA1671 CCDC88A ZZZ3 PPM1F CNOT1

2.91e-084182031534709266
Pubmed

Identification of motif-based interactions between SARS-CoV-2 protein domains and human peptide ligands pinpoint antiviral targets.

C15orf39 LMTK3 ALMS1 AARS2 SCAPER MKI67 CCDC33 ZFAT TCF20 DNAH2 SF3B1

1.43e-072332031137704626
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

TRPM7 PPP1R12A ANKRD27 DDX1 NEDD4 ALMS1 PRRC2C SVIL FOXK1 TCF20 RAB11FIP1 HDAC7 EPN2 KIAA1671 CCDC88A MACF1 CLINT1 PALLD TNPO3 AQR

1.89e-078612032036931259
Pubmed

Endothelial epsin deficiency decreases tumor growth by enhancing VEGF signaling.

KDR EPN1 EPN2

1.96e-073203323187125
Pubmed

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.

DENND2A PPP1R12A NDUFS1 DDX1 MAGI2 SACS PRRC2C SVIL GLUD1 GLUD2 SCAPER IMMT HSP90AB1 BIN1 DNAJC13 PKP4 PPP1R9A MTHFS EPN2 ARHGAP5 MISP CSE1L SF3B1 MACF1 CTNND2 CNOT1

3.15e-0714312032637142655
Pubmed

In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.

MYLK PPP1R12A NDUFS1 DDX1 FRA10AC1 ACSM3 SACS PRRC2C GLUD1 GLUD2 RETREG1 KDR HDGFL2 IMMT HSP90AB1 CCDC185 SMCHD1 PPP1R9A SHB DNAH2 ESF1 ADAMTS12 SF3B1 MACF1 ZNF84 MYBPC2

3.64e-0714422032635575683
Pubmed

HENA, heterogeneous network-based data set for Alzheimer's disease.

APBB3 ALMS1 CDC42EP2 IMMT BIN1 ANGEL1 CCDC88A MACF1

5.64e-07120203831413325
Pubmed

ISG15 Connects Autophagy and IFN-γ-Dependent Control of Toxoplasma gondii Infection in Human Cells.

PPP1R12A DDX1 UBTF PRRC2C IMMT HSP90AB1 DPY19L1 ATP13A1 MISP CSE1L CLINT1

5.77e-072682031133024031
Pubmed

The epsin family of endocytic adaptors promotes fibrosarcoma migration and invasion.

EPN1 EPN3 EPN2

7.80e-074203320709745
Pubmed

Vertebrate extracellular matrix protein hemicentin-1 interacts physically and genetically with basement membrane protein nidogen-2.

HMCN2 NID2 HMCN1

7.80e-074203336007682
Pubmed

Genetic reduction of vascular endothelial growth factor receptor 2 rescues aberrant angiogenesis caused by epsin deficiency.

KDR EPN1 EPN2

7.80e-074203324311377
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

NEDD4 KIAA0319 MAGI2 PRRC2C CACNA1H USP15 UNC13B TCF20 PPP1R9A HEATR5A MACF1 ASXL2 AQR

9.27e-074072031312693553
Pubmed

SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.

PPP1R12A DDX46 ALMS1 PRRC2C USP15 TCF20 RBBP4 SMCHD1 TEAD4 ESF1 KIAA1671 ZZZ3 CLINT1 CNOT1 PALLD

9.48e-075492031538280479
Pubmed

Interaction network of human early embryonic transcription factors.

BCORL1 C15orf39 ALMS1 GLUD1 MKI67 IMMT FOXK1 TCF20 KIAA1671 ZZZ3 PAXIP1 ASXL2

1.21e-063512031238297188
Pubmed

JunB is essential for mammalian placentation.

MKI67 PRAP1 KDR TIMP3

1.46e-0615203410022836
Pubmed

Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.

C15orf39 ZZEF1 ANKRD27 DDX1 PRRC2C EPN1 PKP4 ANGEL1 MORC2 ESF1 KLHL11 CCDC88A DROSHA PALLD AQR HR

1.59e-066502031638777146
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

NDUFS1 DDX46 UBTF PRRC2C MKI67 IMMT TCF20 RBBP4 SMCHD1 ECPAS ESF1 CSE1L SF3B1 MACF1 CNOT1 AQR

1.69e-066532031622586326
Pubmed

ZZW-115-dependent inhibition of NUPR1 nuclear translocation sensitizes cancer cells to genotoxic agents.

PPP1R12A DDX1 DDX46 P3H1 UBTF SVIL MKI67 HDGFL2 IMMT RBBP4 SMCHD1 KIAA1671 MISP SF3B1 MACF1 CLINT1

1.93e-066602031632780723
Pubmed

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.

DCDC1 PPP1R12A ZZEF1 UBE2R2 ZNF469 HMCN2 ALMS1 PRPF40B SCAPER FOXK1 SAMD1 NID2 RBBP4 PKP4 ANGEL1 RAB11FIP1 KIAA1671 ZZZ3 DROSHA MACF1 KIF18B

2.72e-0611162032131753913
Pubmed

Identification of novel Ack1-interacting proteins and Ack1 phosphorylated sites in mouse brain by mass spectrometry.

DENND2A PPP1R12A NEDD4 SVIL PKP4 CTNND2

2.72e-0667203629254152
Pubmed

Identifying biological pathways that underlie primordial short stature using network analysis.

DDX1 DDX46 AARS2 SACS UBTF SVIL GLUD1 MKI67 IMMT HSP90AB1 TCF20 RBBP4 SMCHD1 PPP1R9A KIAA1671 CSE1L SF3B1 MACF1 CNOT1 AQR

2.74e-0610242032024711643
Pubmed

The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.

WWOX BCORL1 DDX1 DDX46 BRCA2 UBTF PRRC2C MKI67 HDGFL2 IMMT HSP90AB1 TCF20 RBBP4 SMCHD1 ESF1 ZZZ3 SF3B1 CLINT1 KIF18B

3.72e-069542031936373674
Pubmed

Epsin deficiency impairs endocytosis by stalling the actin-dependent invagination of endocytic clathrin-coated pits.

EPN1 EPN3 EPN2

3.87e-066203325122462
Pubmed

Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.

ITGA5 P3H1 UBTF SVIL MKI67 HSP90AB1 DNAJC13 PKP4 PPP1R9A TNS2 RAB11FIP1 ESF1 KIAA1671 ARHGAP5 MTMR7 CCDC88A CSE1L PPM1F CLINT1 CNOT1

3.92e-0610492032027880917
Pubmed

Proteomic analysis of integrin-associated complexes identifies RCC2 as a dual regulator of Rac1 and Arf6.

ITGA5 NDUFS1 DDX1 GLUD1 SYK EPN1 USP15 IMMT HSP90AB1 RBBP4 SMCHD1 ECPAS CSE1L SF3B1 MACF1 CNOT1

4.63e-067072031619738201
Pubmed

A BioID-Derived Proximity Interactome for SARS-CoV-2 Proteins.

NDUFS1 NEDD4 ACSM3 P3H1 UBTF CDC42EP2 EPN1 NDST1 BIN1 PKP4 PPP1R9A ANGEL1 RAB11FIP1 KIAA1671 CCDC88A MACF1

5.72e-067192031635337019
Pubmed

The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.

NDUFS1 DDX1 DDX46 AARS2 IMMT FOXK1 HSP90AB1 DNAJC13 RBBP4 ECPAS CSE1L SF3B1 CLINT1 CNOT1 TNPO3

5.90e-066382031533239621
Pubmed

Phosphorylation of Rab-coupling protein by LMTK3 controls Rab14-dependent EphA2 trafficking to promote cell:cell repulsion.

ITGA5 LMTK3 RAB11FIP1

6.74e-067203328294115
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

GPRASP1 TRPM7 APBB3 MAGI2 SACS GLUD1 RETREG1 IMMT GPRASP2 HSP90AB1 UNC13B NDST1 BIN1 ATP13A1 ADAMTS8 ARHGAP5 SF3B1 NSMF DROSHA MACF1 ZNF84 CTNND2

7.01e-0612852032235914814
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

ACSS1 ALMS1 AARS2 SACS SCAPER FLRT2 SLC4A8 ATP13A1 USP37 MORC2 EPN2 MACF1 PALLD

7.49e-064932031315368895
Pubmed

Proteomic and yeast 2-hybrid screens to identify PTEN binding partners.

STK11IP NDUFS1 P3H1 GLUD1 GLUD2 HSP90AB1 CCDC88A SF3B1 TNPO3

7.98e-06226203937839992
Pubmed

SR protein kinases promote splicing of nonconsensus introns.

ITGA5 DDX46 HMCN2 PRRC2C UNC13B DNAJC13 SMCHD1 SF3B1 MACF1 CTNND2 PALLD

1.01e-053612031126167880
Pubmed

An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.

PPP1R12A C15orf39 STYXL2 NDUFS1 DDX1 USP15 IMMT FOXK1 DNAJC13 RAB11FIP1 HDAC7 ESF1 EPN2 KIAA1671 CCDC88A CSE1L BLOC1S3 UQCC1 CLINT1 KIF18B CNOT1 TNPO3

1.08e-0513212032227173435
Pubmed

Prediction of the coding sequences of mouse homologues of FLJ genes: the complete nucleotide sequences of 110 mouse FLJ-homologous cDnas identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

ANKRD27 GPAT2 GALNT10 RAB11FIP1 HDAC7 ZZZ3

1.09e-0585203615449545
Pubmed

Functional proteomics mapping of a human signaling pathway.

ZZEF1 ANKRD27 NEDD4 EPN1 EPN3 NID2 EPN2 ARHGAP5 SF3B1 DROSHA PAXIP1 MACF1 ASXL2 TNPO3

1.12e-055912031415231748
Pubmed

The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.

DDX1 DDX46 UBTF PRRC2C SCAPER MKI67 SAMD1 DNAJC13 RBBP4 SMCHD1 ESF1 CSE1L DROSHA MACF1 CNOT1 AQR

1.12e-057592031635915203
Pubmed

Human transcription factor protein interaction networks.

BCORL1 C15orf39 DDX1 ALMS1 UBTF PRRC2C SVIL GLUD1 MKI67 IMMT FOXK1 TCF20 KBTBD6 SMCHD1 ETV7 MORC2 ZNF691 KIAA1671 ZZZ3 CSE1L PAXIP1 ASXL2 CNOT1

1.16e-0514292032335140242
Pubmed

Laser capture microdissection and cDNA array analysis for identification of mouse KIAA/FLJ genes differentially expressed in the embryonic dorsal spinal cord.

KIAA0319 CACNA1H MORC2 MACF1

1.78e-0527203419026994
Pubmed

Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.

ZNF831 ALMS1 UBTF PRRC2C HDGFL2 DPY19L1 RBBP4 SMCHD1 CSE1L CNOT1 CCDC9 AQR

2.27e-054692031227634302
Pubmed

Perilipin+ embryonic preadipocytes actively proliferate along growing vasculatures for adipose expansion.

ITGA5 MKI67 KDR

2.28e-0510203326243869
Pubmed

RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy.

ALMS1 SVIL MKI67 TCF20 MTHFS KIAA1671 CCDC88A MACF1 CNOT1

2.66e-05263203934702444
Pubmed

Defining the human deubiquitinating enzyme interaction landscape.

GPRASP1 NDUFS1 P3H1 USP15 IMMT GPRASP2 FOXK1 UNC13B KBTBD6 PPP1R9A USP37 CSE1L ASXL2 CLINT1 CDC34 CNOT1 TNPO3 AQR

2.78e-0510052031819615732
Pubmed

Immune-related zinc finger gene ZFAT is an essential transcriptional regulator for hematopoietic differentiation in blood islands.

MKI67 KDR ZFAT

3.12e-0511203320660741
Pubmed

Acetylation of ELF5 suppresses breast cancer progression by promoting its degradation and targeting CCND1.

DDX1 ZNF469 DDX46 SYK FOXK1 TENT4A RBBP4 ECPAS CSE1L SF3B1 CLINT1 CCDC9 PALLD TNPO3

3.34e-056532031433742100
Pubmed

Glutamate Delta-1 Receptor Regulates Inhibitory Neurotransmission in the Nucleus Accumbens Core and Anxiety-Like Behaviors.

GLUD1 GLUD2

3.39e-052203234173171
Pubmed

Glutamate dehydrogenase is essential to sustain neuronal oxidative energy metabolism during stimulation.

GLUD1 GLUD2

3.39e-052203228621566
Pubmed

GluD1 knockout mice with a pure C57BL/6N background show impaired fear memory, social interaction, and enhanced depressive-like behavior.

GLUD1 GLUD2

3.39e-052203232078638
Pubmed

Development of mice with brain-specific deletion of floxed glud1 (glutamate dehydrogenase 1) using cre recombinase driven by the nestin promoter.

GLUD1 GLUD2

3.39e-052203223595828
Pubmed

Targeted disruption of the murine Bin1/Amphiphysin II gene does not disable endocytosis but results in embryonic cardiomyopathy with aberrant myofibril formation.

MKI67 BIN1

3.39e-052203212773571
Pubmed

Interaction between glutamate dehydrogenase (GDH) and L-leucine catabolic enzymes: intersecting metabolic pathways.

GLUD1 GLUD2

3.39e-052203221621574
Pubmed

Identification of the molecular dysfunction caused by glutamate dehydrogenase S445L mutation responsible for hyperinsulinism/hyperammonemia.

GLUD1 GLUD2

3.39e-052203228911206
Pubmed

Delineation of glutamate pathways and secretory responses in pancreatic islets with β-cell-specific abrogation of the glutamate dehydrogenase.

GLUD1 GLUD2

3.39e-052203222875990
Pubmed

Molecular basis of human glutamate dehydrogenase regulation under changing energy demands.

GLUD1 GLUD2

3.39e-052203215578726
Pubmed

Important role of Ser443 in different thermal stability of human glutamate dehydrogenase isozymes.

GLUD1 GLUD2

3.39e-052203215044002
Pubmed

NMP-7 inhibits chronic inflammatory and neuropathic pain via block of Cav3.2 T-type calcium channels and activation of CB2 receptors.

CACNA1H CNR2

3.39e-052203225481027
Pubmed

Induction of excitatory and inhibitory presynaptic differentiation by GluD1.

GLUD1 GLUD2

3.39e-052203222138648
Pubmed

Glutamate Dehydrogenase Is Important for Ammonia Fixation and Amino Acid Homeostasis in Brain During Hyperammonemia.

GLUD1 GLUD2

3.39e-052203234220417
Pubmed

Protein kinase C-theta (PKCθ) phosphorylates and inhibits the guanine exchange factor, GIV/Girdin.

CCDC88A PRKCQ

3.39e-052203223509302
Pubmed

Expression of human GLUD1 and GLUD2 glutamate dehydrogenases in steroid producing tissues.

GLUD1 GLUD2

3.39e-052203226241911
Pubmed

Differential levels of glutamate dehydrogenase 1 (GLUD1) in Balb/c and C57BL/6 mice and the effects of overexpression of the Glud1 gene on glutamate release in striatum.

GLUD1 GLUD2

3.39e-052203221446915
Pubmed

Dual role of the tyrosine kinase GTK and the adaptor protein SHB in beta-cell growth: enhanced beta-cell replication after 60% pancreatectomy and increased sensitivity to streptozotocin.

SHB FRK

3.39e-052203211786382
Pubmed

Double Knockout of the Na+-Driven Cl-/HCO3- Exchanger and Na+/Cl- Cotransporter Induces Hypokalemia and Volume Depletion.

SLC4A8 SLC12A3

3.39e-052203227151921
Pubmed

Curvature of clathrin-coated pits driven by epsin.

EPN1 EPN2

3.39e-052203212353027
Pubmed

GluD1 binds GABA and controls inhibitory plasticity.

GLUD1 GLUD2

3.39e-052203238060673
Pubmed

Inhibition of Cav 3.2 calcium channels: A new target for colonic hypersensitivity associated with low-grade inflammation.

SCN10A CACNA1H

3.39e-052203230714145
Pubmed

Gene expression patterns in the hippocampus during the development and aging of Glud1 (Glutamate Dehydrogenase 1) transgenic and wild type mice.

GLUD1 GLUD2

3.39e-052203224593767
Pubmed

Interaction of S-SCAM with neural plakophilin-related Armadillo-repeat protein/delta-catenin.

MAGI2 CTNND2

3.39e-052203210080919
Pubmed

Potentiation of neuronal activity by tonic GluD1 current in brain slices.

GLUD1 GLUD2

3.39e-052203237154294
Pubmed

Deletion of glutamate dehydrogenase 1 (Glud1) in the central nervous system affects glutamate handling without altering synaptic transmission.

GLUD1 GLUD2

3.39e-052203222924626
Pubmed

Genetic alteration of endothelial heparan sulfate selectively inhibits tumor angiogenesis.

KDR NDST1

3.39e-052203217470635
Pubmed

Nerve tissue-specific (GLUD2) and housekeeping (GLUD1) human glutamate dehydrogenases are regulated by distinct allosteric mechanisms: implications for biologic function.

GLUD1 GLUD2

3.39e-052203211032875
Pubmed

TRPM7 and CaV3.2 channels mediate Ca2+ influx required for egg activation at fertilization.

TRPM7 CACNA1H

3.39e-052203230322909
Pubmed

Localization of Human Glutamate Dehydrogenases Provides Insights into Their Metabolic Role and Their Involvement in Disease Processes.

GLUD1 GLUD2

3.39e-052203229943084
Pubmed

Identification and localization of a neurally expressed member of the plakoglobin/armadillo multigene family.

PKP4 CTNND2

3.39e-05220329342840
Pubmed

Glutamate dehydrogenase deficiency disrupts glutamate homeostasis in hippocampus and prefrontal cortex and impairs recognition memory.

GLUD1 GLUD2

3.39e-052203231898404
Pubmed

Birth and adaptive evolution of a hominoid gene that supports high neurotransmitter flux.

GLUD1 GLUD2

3.39e-052203215378063
Pubmed

Widening Spectrum of Cellular and Subcellular Expression of Human GLUD1 and GLUD2 Glutamate Dehydrogenases Suggests Novel Functions.

GLUD1 GLUD2

3.39e-052203227422263
Pubmed

Critical role of the cysteine 323 residue in the catalytic activity of human glutamate dehydrogenase isozymes.

GLUD1 GLUD2

3.39e-052203215750346
Pubmed

Molecular cloning, structure and expression analysis of a full-length mouse brain glutamate dehydrogenase cDNA.

GLUD1 GLUD2

3.39e-05220321711373
Pubmed

Motif mimetic of epsin perturbs tumor growth and metastasis.

KDR EPN2

3.39e-052203226571402
Pubmed

Transcriptomic responses in mouse brain exposed to chronic excess of the neurotransmitter glutamate.

GLUD1 GLUD2

3.39e-052203220529287
Pubmed

Determination of glutamate dehydrogenase activity and its kinetics in mouse tissues using metabolic mapping (quantitative enzyme histochemistry).

GLUD1 GLUD2

3.39e-052203225124006
Pubmed

Unexpected histone H3 tail-clipping activity of glutamate dehydrogenase.

GLUD1 GLUD2

3.39e-052203223673664
Pubmed

Lack of evidence for direct ligand-gated ion channel activity of GluD receptors.

GLUD1 GLUD2

3.39e-052203239052831
Pubmed

Metabolism changes during aging in the hippocampus and striatum of glud1 (glutamate dehydrogenase 1) transgenic mice.

GLUD1 GLUD2

3.39e-052203224442550
Pubmed

The Amplifying Pathway of the β-Cell Contributes to Diet-induced Obesity.

GLUD1 GLUD2

3.39e-052203227137930
Pubmed

GDH-Dependent Glutamate Oxidation in the Brain Dictates Peripheral Energy Substrate Distribution.

GLUD1 GLUD2

3.39e-052203226440896
Pubmed

Mammalian hemicentin 1 is assembled into tracks in the extracellular matrix of multiple tissues.

HMCN2 HMCN1

3.39e-052203232035013
Pubmed

Study of structure-function relationships in human glutamate dehydrogenases reveals novel molecular mechanisms for the regulation of the nerve tissue-specific (GLUD2) isoenzyme.

GLUD1 GLUD2

3.39e-052203212742085
Pubmed

The adaptor protein shb binds to tyrosine 1175 in vascular endothelial growth factor (VEGF) receptor-2 and regulates VEGF-dependent cellular migration.

KDR SHB

3.39e-052203215026417
Pubmed

Mitochondrial targeting adaptation of the hominoid-specific glutamate dehydrogenase driven by positive Darwinian selection.

GLUD1 GLUD2

3.39e-052203218688271
Pubmed

The complex regulation of human glud1 and glud2 glutamate dehydrogenases and its implications in nerve tissue biology.

GLUD1 GLUD2

3.39e-052203222658952
Pubmed

Deficiency of the tensin2 gene in the ICGN mouse: an animal model for congenital nephrotic syndrome.

ITGA5 TNS2

3.39e-052203216688531
Pubmed

A peptide derived from TIMP-3 inhibits multiple angiogenic growth factor receptors and tumour growth and inflammatory arthritis in mice.

KDR TIMP3

3.39e-052203224129822
Pubmed

Increases in anterograde axoplasmic transport in neurons of the hyper-glutamatergic, glutamate dehydrogenase 1 (Glud1) transgenic mouse: Effects of glutamate receptors on transport.

GLUD1 GLUD2

3.39e-052203238124277
Pubmed

Deletion of glutamate dehydrogenase in beta-cells abolishes part of the insulin secretory response not required for glucose homeostasis.

GLUD1 GLUD2

3.39e-052203219015267
Pubmed

Human GLUD1 and GLUD2 glutamate dehydrogenase localize to mitochondria and endoplasmic reticulum.

GLUD1 GLUD2

3.39e-052203219448744
Pubmed

Serum VEGF levels and tissue activation of VEGFR2/KDR receptors in patients with breast and gynecologic cancer.

KDR UQCC1

3.39e-052203221208810
Pubmed

Single amino acid substitution (G456A) in the vicinity of the GTP binding domain of human housekeeping glutamate dehydrogenase markedly attenuates GTP inhibition and abolishes the cooperative behavior of the enzyme.

GLUD1 GLUD2

3.39e-052203211950837
GeneFamilyBlood group antigens|CD molecules|I-set domain containing|Immunoglobulin like domain containing

PRTG MYLK HMCN2 KDR HMCN1 PALLD MYBPC2

2.08e-041611357593
GeneFamilyArmadillo repeat containing|Protein phosphatase 1 regulatory subunits

GPRASP1 GPRASP2 PKP4 CTNND2

2.93e-04431354409
GeneFamilySH2 domain containing

SHD SYK SHB TNS2 FRK

9.62e-041011355741
GeneFamilyFibronectin type III domain containing

PRTG MYLK FLRT2 USH2A EPHA5 MYBPC2

1.28e-031601356555
GeneFamilyFibulins

HMCN2 HMCN1

1.50e-0381352556
GeneFamilyArmadillo repeat containing|Protein phosphatase 1 regulatory subunits

PPP1R12A LMTK3 SACS MKI67 ANKRD42 PPP1R9A

2.40e-031811356694
CoexpressionAtlasDevelopingGonad_e12.5_epididymis_emap-29139_top-relative-expression-ranked_500

TRPM7 UBTF PRRC2C FLRT2 GPAT2 IMMT HSP90AB1 MGAM DNAJC13 RBBP4 PKP4 ESF1 SF3B1 DPPA4

2.87e-0540319914gudmap_developingGonad_e12.5_epididymis_500
CoexpressionAtlasDevelopingGonad_e14.5_ epididymis_emap-29141_top-relative-expression-ranked_500

TRPM7 PDPK1 BCORL1 UBTF PRRC2C FLRT2 IMMT MGAM DNAJC13 RBBP4 PKP4 SF3B1 TIMP3 ZFTA

3.75e-0541319914gudmap_developingGonad_e14.5_ epididymis_500
CoexpressionAtlasDevelopingGonad_e14.5_ ovary_emap-6699_top-relative-expression-ranked_1000

WWOX PDPK1 MAGI2 ALMS1 BRCA2 SACS SCAPER FLRT2 GPAT2 IMMT DNAJC13 RBBP4 PKP4 ECPAS ESF1 ARHGAP5 SF3B1 HMCN1 DPPA4 ASXL2

4.40e-0577619920gudmap_developingGonad_e14.5_ ovary_1000
CoexpressionAtlasDevelopingGonad_e16.5_epididymis_emap-29702_top-relative-expression-ranked_1000

MYLK TRPM7 PDPK1 BCORL1 UBTF PRRC2C KDR FLRT2 IMMT HSP90AB1 NDST1 MGAM DNAJC13 RBBP4 PKP4 ESF1 ARHGAP5 SF3B1 TIMP3 ZFTA

5.64e-0579019920gudmap_developingGonad_e16.5_epididymis_1000
CoexpressionAtlasDevelopingGonad_e12.5_epididymis_emap-29139_k-means-cluster#5_top-relative-expression-ranked_500

TRPM7 PRRC2C FLRT2 IMMT MGAM DNAJC13 RBBP4 PKP4

8.73e-051501998gudmap_developingGonad_e12.5_epididymis_k5_500
CoexpressionAtlasFacebaseRNAseq_e10.5_Maxillary Arch_top-relative-expression-ranked_2500_k-means-cluster#5

PPP1R12A NDUFS1 NEDD4 DDX46 BRCA2 MKI67 GPRASP2 PKP4 DNAH2 ECPAS ESF1 EPN2 ARHGAP5 ZZZ3 MACF1 ASXL2 EPHA5

9.52e-0562919917Facebase_RNAseq_e10.5_Maxillary Arch_2500_K5
CoexpressionAtlasDevelopingGonad_e16.5_epididymis_emap-29702_top-relative-expression-ranked_500

TRPM7 PDPK1 BCORL1 PRRC2C FLRT2 IMMT MGAM DNAJC13 RBBP4 PKP4 SF3B1 TIMP3 ZFTA

1.26e-0440619913gudmap_developingGonad_e16.5_epididymis_500
CoexpressionAtlasDevelopingGonad_e16.5_epididymis_emap-29702_k-means-cluster#2_top-relative-expression-ranked_500

TRPM7 BCORL1 PRRC2C FLRT2 IMMT DNAJC13 RBBP4 PKP4

1.49e-041621998gudmap_developingGonad_e16.5_epididymis_500_k2
CoexpressionAtlasFacebaseRNAseq_e8.5_Hind Brain Neural Epithelium_top-relative-expression-ranked_2500_k-means-cluster#3

BCORL1 DDX46 ALMS1 BRCA2 PRRC2C CEP126 HEATR5A USP37 ECPAS ESF1 CSE1L PAXIP1 ZC3H12C CTNND2 CNOT1

1.57e-0453219915Facebase_RNAseq_e8.5_Hind Brain Neural Epithelium_2500_K3
CoexpressionAtlasStem Cells, SC.LTSL.BM, IgM- CD24- CD117+ IL7R- CD150+ CD48- AA4.1+ CD43+, Bone marrow, avg-2

GPRASP1 NEDD4 BRCA2 MKI67 POGLUT2 RAD54L PGLYRP1 PPP1R9A HEATR5A ARHGAP6 TIMP3 PRKCQ KIF18B

1.84e-0442219913GSM399442_500
CoexpressionAtlasDevelopingKidney_e15.5_Medullary collecting duct_emap-28063_k-means-cluster#4_top-relative-expression-ranked_1000

PPP1R12A DDX46 PRRC2C SCAPER IMMT DPY19L1 PPP1R9A ECPAS ERCC6L2 ASXL2

1.85e-0426119910gudmap_developingKidney_e15.5_Medullary collecting duct_1000_k4
CoexpressionAtlasDevelopingGonad_e14.5_ epididymis_emap-29141_top-relative-expression-ranked_1000

TRPM7 PDPK1 BCORL1 UBTF PRRC2C KDR FLRT2 IMMT HSP90AB1 NDST1 MGAM DNAJC13 RBBP4 PKP4 ESF1 PIEZO2 SF3B1 TIMP3 ZFTA

2.01e-0480119919gudmap_developingGonad_e14.5_ epididymis_1000
CoexpressionAtlasfacebase_RNAseq_e10.5_NeuroEpith_central_2500_K4

DENND2A TRPM7 ACSS1 ZC3H12B LMTK3 INKA2 SHD UBE2R2 ALMS1 BRCA2 PRPF40B MKI67 CACNA1H CEP126 UNC13B ENGASE ANKRD42 SLC4A8 USP37 ZNF691 ESF1 MTMR7 CCDC88A CSE1L ZC3H12C EML1 KIF18B

2.03e-04137019927facebase_RNAseq_e10.5_NeuroEpith_central_2500_K4
CoexpressionAtlasFacebaseRNAseq_e10.5_Mandibular Arch_top-relative-expression-ranked_1000_k-means-cluster#3

DDX46 ALMS1 CACNA1H GPRASP2 DNAH2 USP37 CCDC88A MACF1 CDH7 EPHA5

2.51e-0427119910Facebase_RNAseq_e10.5_Mandibular Arch_1000_K3
ToppCellTCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-1|TCGA-Pancreas / Sample_Type by Project: Shred V9

MYLK PPP1R12A DDX46 ALMS1 SMCHD1 HEATR5A USP37 ARHGAP6 HMCN1 ASXL2

1.50e-081862031003db813598b67b1e08f759758a1c2023396921fa
ToppCellControl-Fibroblasts-Alveolar_FB|Control / group, cell type (main and fine annotations)

DENND2A MYLK ADAMTS8 ADAMTS12 ARHGAP6 PIEZO2 HMCN1 TIMP3 MACF1 PALLD

1.58e-081872031092d468dde81125d51daf7abd4703741abe1ab91c
ToppCellnucseq-Mesenchymal-Fibroblastic-Fibroblastic_2-AF1|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

DENND2A MYLK ADAMTS8 ADAMTS12 ARHGAP6 PIEZO2 HMCN1 TIMP3 MACF1 PALLD

1.93e-08191203106688cee34beee4f151ac17fccbc9c26a9aad72e1
ToppCellnucseq-Mesenchymal-Fibroblastic-Fibroblastic_2|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

DENND2A MYLK ADAMTS8 ADAMTS12 ARHGAP6 PIEZO2 HMCN1 TIMP3 MACF1 PALLD

2.03e-081922031099ce9e3c4c50cf64ebb62145f2b5420efa0db309
ToppCellChildren_(3_yrs)-Mesenchymal-matrix_fibroblast_1_cell|Children_(3_yrs) / Lineage, Cell type, age group and donor

MYLK MAGI2 ADAMTS8 ADAMTS12 ARHGAP6 PIEZO2 HMCN1 TIMP3 MACF1 PALLD

2.13e-081932031099525545552b371c86b18b6ea6f4897dc6e9a9ec
ToppCellChildren_(3_yrs)-Mesenchymal-matrix_fibroblast_1_cell-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

DENND2A MYLK ADAMTS8 ADAMTS12 ARHGAP6 PIEZO2 HMCN1 TIMP3 MACF1 PALLD

2.13e-0819320310b3ad5ff480d99217f36cc7471e5a96a519ddb409
ToppCellChildren_(3_yrs)-Mesenchymal|Children_(3_yrs) / Lineage, Cell type, age group and donor

DENND2A MYLK MAGI2 ADAMTS8 ADAMTS12 ARHGAP6 PIEZO2 HMCN1 TIMP3 PALLD

2.47e-0819620310bc94909f9b2dc08a59eef1914148b69720569c8f
ToppCellParenchymal-NucSeq-Stromal|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

DENND2A MYLK FLRT2 ADAMTS8 ADAMTS12 ARHGAP6 PIEZO2 HMCN1 TIMP3 PALLD

2.99e-0820020310cf433f9b43d7db07acaf70e060f8f77c974e72f3
ToppCellParenchymal-NucSeq-Stromal-Fibroblastic|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

DENND2A MYLK FLRT2 ADAMTS8 ADAMTS12 ARHGAP6 PIEZO2 HMCN1 TIMP3 PALLD

2.99e-0820020310311fab076f2ceb258e3970eb21e39344b894042a
ToppCellControl-Endothelial-Endothelial-Gen_Cap|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

NEDD4 KDR PPP1R9A ANGEL1 KIAA1671 PIEZO2 HMCN1 ZC3H12C CTNND2

2.69e-071932039e1d546165dcc2392f540162206852c4717d7306f
ToppCellMesenchymal-matrix_fibroblast_1_cell|World / Lineage, Cell type, age group and donor

DENND2A MYLK MAGI2 ADAMTS8 ADAMTS12 ARHGAP6 PIEZO2 HMCN1 PALLD

2.69e-071932039acad568621ed677031797b8c2e34dafea798d681
ToppCellCOVID-19-Fibroblasts-Alveolar_FB|COVID-19 / group, cell type (main and fine annotations)

DENND2A MYLK MAGI2 ADAMTS8 ADAMTS12 ARHGAP6 PIEZO2 HMCN1 PALLD

2.93e-071952039603050beeb33c331d4b2e3fa46cae3f3e0e4bdc7
ToppCellAdult-Mesenchymal-matrix_fibroblast_1_cell-D122|Adult / Lineage, Cell type, age group and donor

DENND2A MYLK ADAMTS8 ADAMTS12 ARHGAP6 PIEZO2 HMCN1 TIMP3 PALLD

2.93e-071952039aa0add081881d349099d12efca5cdee098038d4e
ToppCellAdult-Mesenchymal-matrix_fibroblast_1_cell|Adult / Lineage, Cell type, age group and donor

DENND2A MYLK ADAMTS8 ADAMTS12 ARHGAP6 PIEZO2 HMCN1 TIMP3 PALLD

2.93e-07195203961c9e09fc84d1012e472185d70ad0a06cee30d6e
ToppCellnucseq-Mesenchymal-Fibroblastic|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

DENND2A MYLK ADAMTS12 ARHGAP6 PIEZO2 HMCN1 TIMP3 MACF1 PALLD

3.06e-0719620397d8505dac15fa59935ccf592afc54b04c4c6554f
ToppCellnucseq-Mesenchymal|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

DENND2A MYLK ADAMTS12 ARHGAP6 PIEZO2 HMCN1 TIMP3 MACF1 PALLD

3.33e-0719820398f52243ca8b9ba68a75ae411506a3a6de258eb97
ToppCellParenchymal-NucSeq-Stromal-Fibroblastic-Fibro_alveolar|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

DENND2A MYLK ADAMTS8 ADAMTS12 ARHGAP6 PIEZO2 HMCN1 TIMP3 PALLD

3.63e-07200203934f52003988ce6329d8deeee1ab875fa77e01e9d
ToppCellBronchial-NucSeq-Stromal-Fibroblastic-Fibro_alveolar|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

DENND2A MYLK ADAMTS8 ADAMTS12 ARHGAP6 PIEZO2 HMCN1 TIMP3 PALLD

3.63e-072002039e8462395fee0a532d1e7ec7f1795f28c42af6541
ToppCellAdult-Mesenchymal-chondrocyte|Adult / Lineage, Cell type, age group and donor

MYLK CDC42EP2 KBTBD6 TNS2 ADAMTS12 PIEZO2 HMCN1 TIMP3

7.08e-0715920383f7305ee76447064b5c846c4f576360a2f7e0b7c
ToppCellB_cells-pDCs|World / Immune cells in Kidney/Urine in Lupus Nephritis

SHD KCNK17 ZFAT RUBCNL CCDC88A DNAH12 SLC12A3 DPPA4

1.07e-061682038dc8f94424f60ab56facdcffa969e7f3466ee1b6e
ToppCellTCGA-Lung-Primary_Tumor-Lung_Carcinoma-Lung_Squamous_Cell_Carcinoma-4|TCGA-Lung / Sample_Type by Project: Shred V9

ITGA5 SHD SSC5D ZNF469 NID2 RUBCNL ADAMTS12 MYBPC2

1.07e-061682038aefea14b8b1c1b6a05f827effd22ba15274fddc9
ToppCelldroplet-Heart-nan-3m|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GPRASP1 TRPM7 NEDD4 PRRC2C ARHGAP5 CCDC88A HMCN1 MACF1

1.52e-061762038749b47eac5436fa34e0d243ffbc6f1897f4e431e
ToppCellTCGA-Ovary-Primary_Tumor-Ovarian_Carcinoma-Serous_Cystadenocarcinoma-6|TCGA-Ovary / Sample_Type by Project: Shred V9

ITGA5 SSC5D ZNF469 GALNT10 ADAMTS12 HMCN1 TIMP3 PALLD

1.66e-061782038142879e9393e721f9b05a6bb46995c9d6d713c95
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

DENND2A WWOX TRPM7 ACSS1 SLC4A8 PKP4 ARHGAP6 PRKCQ

2.21e-06185203803f64a7132b13a01ba47187e0e15c13ac88f7cb2
ToppCellControl-Fibroblasts-Other_FB|Control / group, cell type (main and fine annotations)

DENND2A MYLK SSC5D KCNK17 ADAMTS12 ARHGAP6 HMCN1 PALLD

2.39e-061872038bd3739c4a52aa1ba5deffd778e113a9800f7e158
ToppCellControl-Endothelial-Endothelial-Alv_Gen_Intermediate|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

NEDD4 KDR ANGEL1 KIAA1671 PPM1F ZC3H12C EML1 CTNND2

2.59e-0618920385d7ae1ead7f4fbaeec26f651833c9c2106e1e4d1
ToppCellControl-Fibroblasts|Control / group, cell type (main and fine annotations)

DENND2A MYLK ADAMTS12 ARHGAP6 PIEZO2 HMCN1 TIMP3 PALLD

2.69e-0619020383a42a9b98d954685d38a741f44545898d0e3e9ce
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

DENND2A DCDC1 SVIL PKP4 HDAC7 PRKCQ CLINT1 CDH3

2.80e-0619120385a67ff17fb4b9eff641176dff07830c9cd73754e
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

DENND2A DCDC1 SVIL PKP4 HDAC7 PRKCQ CLINT1 CDH3

2.80e-06191203855ab2854a02cdcfc395e49870ccb7290b5e5471d
ToppCelldroplet-Limb_Muscle-nan-18m-Mesenchymal-smooth_muscle_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYLK ACSS1 INKA2 CACNA1H SLC4A8 SLC6A9 MTMR7 TIMP3

2.91e-06192203888472b99970ba0decbf87164fc241a1c77b3b389
ToppCellLPS-IL1RA+antiTNF-Stromal_mesenchymal|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DENND2A MYLK MAGI2 ADAMTS8 ADAMTS12 ARHGAP6 PIEZO2 PALLD

2.91e-0619220383d0cb19f037f604253d7d728689aeaa94251e92b
ToppCellwk_08-11-Mesenchymal-Myofibro_&_SMC-Early_airway_SMC_1|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

MYLK PPP1R12A F13B SSC5D FLRT2 KCNK17 ARHGAP6 PALLD

2.91e-0619220387ae3e1ca8bfc078c0e12a1595ecb0e343dab5d2f
ToppCellCOPD-Stromal-Myofibroblast|Stromal / Disease state, Lineage and Cell class

MYLK ADAMTS8 ADAMTS12 ARHGAP6 PIEZO2 HMCN1 MACF1 PALLD

2.91e-06192203862904f94dfce430456f05066522cbf9bd29f4d7e
ToppCellVE-pDC-|VE / Condition, Cell_class and T cell subcluster

SHD SYK KCNK17 ZFAT RUBCNL CCDC88A SLC12A3 DPPA4

3.02e-061932038583724de588fcde3aeda056138c522dc0225a387
ToppCellVE-pDC|VE / Condition, Cell_class and T cell subcluster

SHD SYK KCNK17 ZFAT RUBCNL CCDC88A SLC12A3 DPPA4

3.02e-061932038bb759dc9ef0ec41d655002f59021d62d62d44289
ToppCellAdult-Mesenchymal-matrix_fibroblast_1_cell-D231|Adult / Lineage, Cell type, age group and donor

DENND2A MYLK ADAMTS8 ADAMTS12 ARHGAP6 PIEZO2 HMCN1 TIMP3

3.02e-061932038ef2f456c094e6e3c6ee81e0668c953cb8d0e1c0a
ToppCellChildren_(3_yrs)-Mesenchymal-matrix_fibroblast_1_cell-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

MYLK MAGI2 ADAMTS8 ADAMTS12 ARHGAP6 PIEZO2 TIMP3 PALLD

3.14e-061942038e93de9428c986b8943fc169258847c650cfab0e5
ToppCellLPS-IL1RA-Endothelial|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ITGA5 NEDD4 KDR PKP4 KIAA1671 ZC3H12C EML1 CTNND2

3.14e-06194203843f92b0533e26633dc94cce554045d641ef8fd76
ToppCellLPS-antiTNF-Stromal_mesenchymal|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DENND2A MYLK MAGI2 ADAMTS8 ADAMTS12 ARHGAP6 PIEZO2 PALLD

3.14e-0619420386e13549f697f7478b34fe71f7dd9d63c5d3db22e
ToppCellLPS-IL1RA-Endothelial-Endothelial|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ITGA5 NEDD4 KDR PKP4 KIAA1671 ZC3H12C EML1 CTNND2

3.14e-0619420381d39d968730a7e85b6161c1c8a6bd38afe9bcad7
ToppCellLPS-antiTNF-Stromal_mesenchymal-Matrix_Fibroblast-Activated_MatrixFB|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DENND2A MYLK MAGI2 ADAMTS8 ADAMTS12 ARHGAP6 PIEZO2 KIAA1755

3.14e-06194203889b706af2b25991fc2707eb24f49ba6ff3ae01f7
ToppCellFetal_29-31_weeks-Mesenchymal-matrix_fibroblast_1_cell|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

DENND2A MYLK MAGI2 ADAMTS8 ADAMTS12 ARHGAP6 PIEZO2 HMCN1

3.14e-061942038011e14d9ed1393275f892060e7708ffadcd0767f
ToppCell11.5-Distal-Mesenchymal-Airway_Smooth_Muscle|Distal / Age, Tissue, Lineage and Cell class

MYLK PPP1R12A SSC5D SVIL FLRT2 KCNK17 ADAMTS8 PALLD

3.39e-06196203805530fe7a5681c2f39b95016cd22ef99d6ac0430
ToppCell3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MYLK ADAMTS8 ADAMTS12 PIEZO2 HMCN1 TIMP3 MACF1 PALLD

3.39e-0619620389737a5f006d37b549f281e1863aca558e1e4dc99
ToppCell3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Alveolar_fibroblasts|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MYLK ADAMTS8 ADAMTS12 PIEZO2 HMCN1 TIMP3 MACF1 PALLD

3.39e-061962038cecf82cd5e0a3835d655f5e7478578674a63ce25
ToppCellnormal_Lung-Fibroblasts-COL13A1+_matrix_FBs|normal_Lung / Location, Cell class and cell subclass

MYLK ADAMTS8 ADAMTS12 PIEZO2 HMCN1 TIMP3 MACF1 PALLD

3.52e-0619720386c57ab2efb8363828e24211c4d45e58bb73a9a4d
ToppCell3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Alveolar_fibroblasts-Alveolar_fibroblasts_L.2.1.1.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MYLK ADAMTS8 ADAMTS12 PIEZO2 HMCN1 TIMP3 MACF1 PALLD

3.52e-06197203813896ec65ccda0b928c91d41112dc01b480036b7
ToppCellParenchymal-NucSeq-Stromal-Fibroblastic-Fibro_myofibroblast|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

DENND2A MYLK SSC5D KCNK17 ARHGAP6 HMCN1 PALLD HR

3.52e-0619720386d0d68d460243a0259ada93ebda40fa7b3088eeb
ToppCell3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Alveolar_fibroblasts-Alveolar_fibroblasts_L.2.1.1.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MYLK ADAMTS8 ADAMTS12 PIEZO2 HMCN1 TIMP3 MACF1 PALLD

3.52e-06197203894a9603cbd3516fbcce871909693b88f20d41713
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ITGA5 KDR FLRT2 TEAD4 KIAA1671 PIEZO2 TIMP3 EML1

3.52e-061972038cd509e49bbdbf991cc5913960ff3ef275ad40628
ToppCelldistal-1-Hematologic-Plasmacytoid_Dendritic|1 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

BCORL1 SHD ZNF469 KCNK17 TMPRSS9 ZFAT SLC12A3 IL9R

3.52e-061972038166d47359df9279ea8c3946f10bd3d4b88c95857
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ITGA5 KDR FLRT2 TEAD4 KIAA1671 PIEZO2 TIMP3 EML1

3.52e-061972038412cb5f37df57121ddd1492021445479c7cbccbf
ToppCellwk_08-11-Mesenchymal-Myofibro_&_SMC|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

MYLK PPP1R12A INKA2 SSC5D SVIL FLRT2 ADAMTS8 PALLD

3.65e-061982038637f11e292b90d86cdc0d0d828eb26f38289c25b
ToppCellAdult-Mesenchymal|Adult / Lineage, Cell type, age group and donor

DENND2A MYLK ADAMTS8 ADAMTS12 ARHGAP6 PIEZO2 HMCN1 TIMP3

3.65e-06198203826e55b409db2a1637c95fae7c54b0abea1ef550c
ToppCellcellseq-Mesenchymal-Fibroblastic-Fibroblastic_2-AF1|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

MYLK ADAMTS8 ADAMTS12 PIEZO2 HMCN1 TIMP3 MACF1 PALLD

3.65e-061982038f1374f7a50244d59c766ac41f44c08c9117407d2
ToppCellLPS_anti-TNF-Mesenchymal_myocytic-Myofibroblastic|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

MYLK PPP1R12A SSC5D ACSM3 SVIL HSP90AB1 CDH3 PALLD

3.79e-061992038e9820d5fb4e8b46973c4c50ac5db8fb4a1bf603b
ToppCell343B-Fibroblasts-Fibroblast-G-|343B / Donor, Lineage, Cell class and subclass (all cells)

MYLK ADAMTS8 ADAMTS12 PIEZO2 HMCN1 TIMP3 MACF1 PALLD

3.79e-0619920389c6d1c328bfbb6547f4c7bb2a784576a56bd72af
ToppCellwk_08-11-Mesenchymal-Myofibro_&_SMC-Early_airway_SMC_2|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

MYLK PPP1R12A INKA2 SSC5D SVIL FLRT2 ADAMTS8 PALLD

3.79e-061992038a207b4891881149d4c50721310690fd794157723
ToppCellcellseq-Mesenchymal-Fibroblastic-Fibroblastic_2|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

MYLK ADAMTS8 ADAMTS12 PIEZO2 HMCN1 TIMP3 MACF1 PALLD

3.79e-06199203866a79732caf2f04c09b4d9832377aa01ca477677
ToppCell343B-Fibroblasts-Fibroblast-G|343B / Donor, Lineage, Cell class and subclass (all cells)

MYLK ADAMTS8 ADAMTS12 PIEZO2 HMCN1 TIMP3 MACF1 PALLD

3.79e-061992038f4b6c095cbe7a38b310adc49be4069e4d56e6a66
ToppCellBronchial-NucSeq-Stromal|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

DENND2A MYLK FLRT2 ADAMTS12 ARHGAP6 PIEZO2 HMCN1 TIMP3

3.93e-062002038389cc775c8419d90fb77cd794376d2160a7bf44e
ToppCellParenchyma_Control_(B.)-Stromal-TX-Fibroblasts-1|Parenchyma_Control_(B.) / Sample group, Lineage and Cell type

MYLK ADAMTS8 ADAMTS12 PIEZO2 HMCN1 TIMP3 MACF1 PALLD

3.93e-062002038aa1a35dcca3b799241eef4237f6eb94660e019f0
ToppCellLung_Parenchyma-Control-Mesenchymal-Mesenchymal-Fibroblasts-1|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

MYLK ADAMTS8 ADAMTS12 PIEZO2 HMCN1 TIMP3 MACF1 PALLD

3.93e-062002038a510deaada669e690329183e18df02870bd204b3
ToppCellLPS_anti-TNF-Mesenchymal_myocytic-Myofibroblastic-Myofibroblast|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

MYLK PPP1R12A SSC5D ACSM3 SVIL HSP90AB1 CDH3 PALLD

3.93e-062002038c596a53c0b63c9deaac7d99fcbdd94ecfa96b86c
ToppCellCOVID-19|World / Disease, condition lineage and cell class

PRRC2C USP15 HSP90AB1 SMCHD1 SF3B1 MACF1 CLINT1 CNOT1

3.93e-0620020387dec470c379cd89f05a0f37c8628b21f136e52f0
ToppCellLung_Parenchyma-Control-Mesenchymal-Mesenchymal-Fibroblasts-1-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

MYLK ADAMTS8 ADAMTS12 PIEZO2 HMCN1 TIMP3 MACF1 PALLD

3.93e-062002038dd4228cbed8a4395166a6332e08d44d88bebe3b9
ToppCelldroplet-Liver-Npc-21m-Myeloid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IL10RB ACSS1 SYK RNF208 PADI1 MTMR7 CDH3

6.96e-061542037d883b3e2a65e4375bea1216eb9bbc86c64ee449c
ToppCellVE-CD8-naive_CD4|VE / Condition, Cell_class and T cell subcluster

MISP3 PRSS36 ACSM3 PKP4 RITA1 ZFTA TNPO3

8.93e-061602037255d2a150bfe19ee3d4d34533feb9c37ce73d225
ToppCell5'-Parenchyma_lung-Immune_Myeloid-Dendritic-plasmacytoid_dendritic_cell-Plasmacytoid_DCs-Plasmacytoid_DCs_L.1.5.1.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SHD KCNK17 CNR2 ZFAT RUBCNL SLC12A3 DPPA4

1.09e-051652037e2a70dd5870fe8708bf630ed3e6eb3f295df0cdf
ToppCelldroplet-Pancreas-Exocrine-24m-Epithelial-pancreatic_acinar_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACSS1 ACSM3 RETREG1 SDR9C7 ADAMTS12 SLC6A9 EPHA5

1.18e-0516720373c06894fc6177f3c204094719904da42f08b9af8
ToppCell390C-Myeloid-Dendritic-pDC|390C / Donor, Lineage, Cell class and subclass (all cells)

SHD KCNK17 ZFAT RUBCNL RAB11FIP1 SLC12A3 DPPA4

1.23e-0516820375a2e7a52b7330dce30823695a7b9b26bc47a69ce
ToppCell(3)_DC_plasmacytoid|World / Lung cell shreds - cell class (v4) and cell subclass (v4)

SHD KCNK17 ZFAT RUBCNL RAB11FIP1 SLC12A3 DPPA4

1.23e-0516820378a913db9b2a1a4ff96fb139734a3834e6aa263f1
ToppCell3'_v3-blood-Mast|blood / Manually curated celltypes from each tissue

ZC3H12B MAGI2 PRAP1 POGLUT2 GPAT2 ZNF691 TIMP3

1.43e-051722037e7a46bbeff749ca59b9f1357409ce1ad59dd22dd
ToppCell3'_v3-blood-Mast-Mast_cells|blood / Manually curated celltypes from each tissue

ZC3H12B PRAP1 KCNK17 TMPRSS9 MORC2 CCDC88A TIMP3

1.66e-051762037b9da3deaf62622d47eb30b6be7548253eee95597
ToppCelldroplet-Pancreas-Exocrine-24m|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IL10RB PRTG ITGA5 ACSM3 EPN3 TIMP3 CDH3

1.72e-051772037a5b54792ef948a1e1de66301a60e051250189f59
ToppCellHealthy/Control-pDC|Healthy/Control / Disease group and Cell class

DCDC1 SHD KCNK17 ZFAT SLC12A3 DPPA4 CTNND2

1.78e-051782037072b346c6bbd63f00efaceda486400a669b3ec48
ToppCell3'-Parenchyma_lung-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel-Lymphatic_EC_differentiating-Lymphatic_EC_differentiating_L.2.5.1.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DENND2A KDR FLRT2 PIEZO2 TIMP3 MACF1 SLC24A1

1.78e-051782037ad3de3e03a401dac64431a541899445262246347
ToppCell367C-Lymphocytic-ILC-ILC-2|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

C15orf39 ZNF441 P3H1 MKI67 SYK CEP126 CCDC9

1.85e-0517920375aa8465e943b6b666c7f8b1937fcc3764bfe91f6
ToppCell390C-Lymphocytic-NK_cells-Proliferating_NK_cell|NK_cells / Donor, Lineage, Cell class and subclass (all cells)

HMCN2 MKI67 RAD54L PKP4 DNAH12 PAXIP1 KIF18B

1.85e-051792037e67ad7ab04d0c1309296f57c1f53c5ca14c213fe
ToppCell5'-Adult-Appendix-Mesenchymal-fibroblastic-Stromal_2_(NPY+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MAGI2 SVIL KCNK17 ADAMTS12 PIEZO2 CTNND2 ZNF333

1.85e-051792037a1ea8daa0fe8900f5a04b555c77fe8ebdaa3908d
ToppCelldroplet-Thymus-nan-24m-Myeloid-nan|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SYK CNR2 BIN1 PGLYRP1 RUBCNL ARHGAP6 MYBPC2

1.99e-0518120372a3092fbadd18967199f1203c11f0dd956417254
ToppCellSevere-Lymphoid-pDC-|Severe / Condition, Lineage, Cell class and cell subclass

SHD KCNK17 ZFAT RUBCNL RAB11FIP1 SLC12A3 DPPA4

1.99e-051812037277ce4c49121da0990a5933b19d2c6af9bbe253e
ToppCell356C-Lymphocytic-CD4_T-cell-Proliferating_T_cell|356C / Donor, Lineage, Cell class and subclass (all cells)

SHD MKI67 KCNK17 TMPRSS9 SDR9C7 DPPA4 CDH7

1.99e-051812037be4f35c9eb5b3083acb2264128f095fac1f3da45
ToppCell3'-GW_trimst-2-LargeIntestine-Mesenchymal-myocytic-SMC_(PART1/CAPN3+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MYLK HMCN2 SVIL ADAMTS8 MACF1 CDH3 PALLD

1.99e-051812037beb2771820956be8b190c0088ae3c4efdb53c897
ToppCellSevere-Lymphoid-pDC|Severe / Condition, Lineage, Cell class and cell subclass

SHD KCNK17 ZFAT RUBCNL RAB11FIP1 SLC12A3 DPPA4

1.99e-0518120372caecb7c5dcdad46fd02b4ffb73cb613ce835187
ToppCellHealthy/Control-pDC|World / Disease group and Cell class

DCDC1 SHD KCNK17 ZFAT SLC12A3 DPPA4 CTNND2

2.06e-05182203797e0eee10905f2cf2bebb09e474629fc224f4397
ToppCell3'-Pediatric_IBD-SmallIntestine-Hematopoietic-Myeloid-pDC|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SHD KCNK17 TMPRSS9 ZFAT CCDC88A SLC12A3 DPPA4

2.06e-05182203702c0824373a0ecebc922d4ca848ace9d570722c4
ToppCell3'-Child04-06-SmallIntestine-Mesenchymal-fibroblastic-Stromal_4_(MMP1+)|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

DENND2A ANKRD42 NYAP2 TIMP3 KIAA1755 ZNF287 MYBPC2

2.13e-051832037269afec240a756eec3bbae5f30ec784281af3433
ToppCellnormal_Lung-Fibroblasts-Myofibroblasts|normal_Lung / Location, Cell class and cell subclass

MYLK SSC5D ZNF469 HMCN2 ADAMTS12 PIEZO2 HMCN1

2.21e-0518420370b336489c10e8c3c957795dd845454f03404382b
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Igfbp6_Pltp|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

SVIL ARHGAP6 HMCN1 TIMP3 GPR156 PRKCQ

2.25e-05124203636dfc702a570e1a1a6dde09f38badf9023ea7287
ToppCellpdx-Tumor_cells-T0|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)

WWOX PDPK1 ACSM3 GLUD1 CACNA1H KIAA1755 CTNND2

2.29e-0518520371d874608aa2062024323512f68889219471b2f00
ToppCellPBMC-Severe-Myeloid-pDC-pDC-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

SHD KCNK17 ZFAT RUBCNL CCDC88A SLC12A3 DPPA4

2.37e-05186203731df1eafa3010bc1be6fc4d4689f1393d69b6b13
ToppCellPBMC-Severe-Myeloid-pDC|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

SHD KCNK17 ZFAT RUBCNL CCDC88A SLC12A3 DPPA4

2.37e-051862037b95be984e308d4f9061274a35995ec558d434e74
ToppCellPBMC-Severe-Myeloid-pDC-pDC-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

SHD KCNK17 ZFAT RUBCNL CCDC88A SLC12A3 DPPA4

2.37e-0518620378f7949740286f64e034d1eb533ebc2c6f71ae966
ToppCellPBMC-Severe-Myeloid-pDC-pDC|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

SHD KCNK17 ZFAT RUBCNL CCDC88A SLC12A3 DPPA4

2.37e-051862037b70cd94c651b56dcf2e55554533a5f1130845390
ToppCellCOVID-19_Severe-Myeloid-pDC|COVID-19_Severe / Disease group, lineage and cell class

SHD KCNK17 ZFAT RUBCNL CCDC88A SLC12A3 DPPA4

2.37e-0518620373db5ed69d49e5d79f990aca0295ddce4c297a05c
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

DCDC1 MAGI2 RETREG1 NID2 PKP4 DGKI PRKCQ

2.37e-051862037f0c8de4f6ae9047b9108a47a2af8c5f42bc103b0
ToppCellPBMC-Severe-Myeloid-pDC|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

SHD KCNK17 ZFAT RUBCNL CCDC88A SLC12A3 DPPA4

2.37e-051862037eaa431ccd4cdd36fe06a44987603ec9979025aa8
ToppCellPBMC-Severe-Myeloid-pDC-pDC|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

SHD KCNK17 ZFAT RUBCNL CCDC88A SLC12A3 DPPA4

2.37e-05186203795c7318e521fb6aa02e244b1e81e6b2a62107756
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

DENND2A WWOX ACSS1 SLC4A8 PKP4 ARHGAP6 PRKCQ

2.37e-0518620371850583d23903d08226aeb0edb3e07b0994330e4
DrugS2A

WWOX MYLK IMMT HSP90AB1 PGLYRP1

1.58e-06232035CID016058643
Drug2-propylpentanoic acid; Down 200; 200uM; MCF7; HT_HG-U133A

ZNF444 BRCA2 UBTF SCAPER SYK CDC42EP2 PADI1 TNS2 MORC2 PPM1F BRF2

1.67e-06197203115211_DN
DrugD-cycloserine [68-41-7]; Up 200; 39.2uM; PC3; HT_HG-U133A

DENND2A ZNF444 MYLK ACSM3 SCAPER SYK CDC42EP2 RAD54L HDAC7 TNPO3

1.26e-05199203107134_UP
DrugOleandomycin phosphate [7060-74-4]; Down 200; 5uM; HL60; HG-U133A

PPP1R12A DDX46 UBTF CNR2 RAD54L DMAC2 ECPAS DROSHA MACF1 MMUT

1.32e-05200203102018_DN
Drugalpha-monofluoromethylputrescine

WWOX GLUD1 GLUD2

1.37e-0562033CID000134201
Diseaseazoospermia (implicated_via_orthology)

UBE2R2 SCAPER NDST1 CDC34

2.50e-05271884DOID:14227 (implicated_via_orthology)
Diseaseprostate adenocarcinoma (biomarker_via_orthology)

KDR PRKCQ

1.21e-0431882DOID:2526 (biomarker_via_orthology)
Diseasefascioliasis (biomarker_via_orthology)

GLUD1 GLUD2

1.21e-0431882DOID:885 (biomarker_via_orthology)
Diseaseplatelet component distribution width

DENND2A ZNF831 ZZEF1 PRRC2C SVIL SYK USP15 NYAP2 TENT4A HDAC7 MACF1 BLOC1S3 CLINT1 ZNF333

3.67e-0475518814EFO_0007984
Diseaseautism spectrum disorder (implicated_via_orthology)

GPRASP2 NDST1 TMPRSS9 TCF20 PKP4 CTNND2

4.44e-041521886DOID:0060041 (implicated_via_orthology)
Diseaseuric acid measurement

DCDC1 TRPM7 DDX1 KIAA0319 UBTF GLUD1 KCNK17 FOXK1 DNAJC13 NYAP2 FRK ASXL2

5.77e-0461018812EFO_0004761
Diseasechildhood absence epilepsy (biomarker_via_orthology)

GLUD1 GLUD2

5.96e-0461882DOID:1825 (biomarker_via_orthology)
Diseasepancreatic cancer (is_implicated_in)

BRCA2 MKI67 KDR RAD54L PALLD

7.70e-041121885DOID:1793 (is_implicated_in)
DiseaseBilateral Wilms Tumor

BCORL1 BRCA2 DROSHA

8.23e-04291883C2930471
DiseaseImmune System Diseases

TRPM7 CNR2

8.30e-0471882C0021053
DiseaseHereditary Sensory Autonomic Neuropathy, Type 5

RETREG1 SCN10A

8.30e-0471882C0020075
Diseaseintellectual disability (implicated_via_orthology)

CAPN9 ITGA5 GPRASP2 NDST1

1.36e-03751884DOID:1059 (implicated_via_orthology)
DiseasePancreatic carcinoma, familial

BRCA2 PALLD

1.41e-0391882C2931038
Diseaseposterior thigh muscle fat infiltration measurement

HMCN2 NYAP2 CCDC87

1.43e-03351883EFO_0020934
DiseaseNephroblastoma

BCORL1 BRCA2 DROSHA

1.56e-03361883C0027708
DiseaseS-7-hydroxywarfarin to S-warfarin ratio measurement

WWOX MAGI2 PRKCQ AQR

1.81e-03811884EFO_0803334
Diseasevaline measurement

GLUD1 USP15 NYAP2

2.11e-03401883EFO_0009792
Diseasedelta-5 desaturase measurement

PRTG NEDD4

2.14e-03111882EFO_0007764
Diseaseairway wall thickness measurement

MAGI2 SDR9C7

2.56e-03121882EFO_0006898
DiseasePARKINSON DISEASE, LATE-ONSET

GLUD2 DNAJC13

2.56e-03121882C3160718
DiseaseConnective Tissue Diseases

ZNF469 PIEZO2

3.01e-03131882C0009782
DiseaseHereditary Motor and Sensory-Neuropathy Type II

RETREG1 MORC2

3.01e-03131882C0270914
Diseasediet measurement

ACSS1 MAGI2 ZNF469 ACSM3 PRPF40B CACNA1H MGAM SLC4A8 TCF20 DPY19L1 FRK DGKI CTNND2 CNOT1 ZNF287

3.06e-03104918815EFO_0008111
Diseaseasymmetric dimethylarginine measurement

ZZEF1 MTHFS

3.49e-03141882EFO_0010463
DiseaseMalignant neoplasm of breast

WWOX PDPK1 BCORL1 NEDD4 BRCA2 MKI67 KDR CNR2 RAD54L NID2 HDAC7 NLRP14 PPM1F MACF1 UQCC1

3.81e-03107418815C0006142
DiseasePancreatic Neoplasm

BRCA2 KDR CNR2 PALLD

3.89e-031001884C0030297
Diseaseepilepsy (implicated_via_orthology)

WWOX SCN10A KCNK17 UNC13B SLC12A3

3.99e-031631885DOID:1826 (implicated_via_orthology)
Diseasehepatic encephalopathy (biomarker_via_orthology)

GLUD1 GLUD2

4.01e-03151882DOID:13413 (biomarker_via_orthology)
DiseaseMalignant neoplasm of pancreas

BRCA2 KDR CNR2 PALLD

4.17e-031021884C0346647
Diseaseretinal drusen

ENGASE CCDC185 CTNND2

4.23e-03511883EFO_1001155
Diseasecoronary thrombosis, GM11992

SCAPER PALLD

4.57e-03161882EFO_0001124, EFO_1000883
Diseasepreeclampsia, hypertension, pregnancy-induced

ZNF831 TNS2

4.57e-03161882EFO_0000668, MONDO_0024664
Diseaselung non-small cell carcinoma (is_marker_for)

PDPK1 BCORL1 MKI67 KDR TIMP3

4.65e-031691885DOID:3908 (is_marker_for)
DiseasePR interval

MAGI2 ZNF469 SCN10A FLRT2 KIAA1755 MACF1 CTNND2 CNOT1 SLC2A11

4.65e-034951889EFO_0004462
Diseasegraft-versus-host disease (is_implicated_in)

IL10RB MKI67

5.16e-03171882DOID:0081267 (is_implicated_in)
DiseaseVascular Diseases

MYLK SLC12A3

5.16e-03171882C0042373
Diseasefactor VII measurement

PRTG NEDD4 PRKCQ

5.24e-03551883EFO_0004619
Diseasecortical thickness

PRTG WWOX DCDC1 ZNF469 UBTF USP15 NYAP2 ADAMTS8 CCDC88A SF3B1 KIAA1755 DGKI MACF1 UQCC1 EML1

5.27e-03111318815EFO_0004840
DiseaseColorectal Carcinoma

TRPM7 SACS MKI67 KDR UNC13B ZZZ3 CSE1L PPM1F CTNND2 CDH7 HR

5.58e-0370218811C0009402
DiseaseR-6-hydroxywarfarin measurement

WWOX DNAH2 PALLD AQR

6.18e-031141884EFO_0803327

Protein segments in the cluster

PeptideGeneStartEntry
PSIDSIQKDPREFAW

PKP4

511

Q99569
LEDAWGETGTKPRPA

CCDC185

106

Q8N715
PGESRWKEQPEDQES

CCDC185

341

Q8N715
KSPESVALIWERDEP

ACSS1

121

Q9NUB1
EPTRAPIWGDTVNVE

CCDC33

286

Q8N5R6
EEVERPKPVADGGWA

ADAMTS8

516

Q9UP79
SRKWRPIASDEIVPG

ATP13A1

306

Q9HD20
EIKVREATSNDPWGP

EPN3

21

Q9H201
EWIPPADTGGRKDVS

EPHA5

376

P54756
PEIVRNGDPSTWVKN

BCORL1

691

Q5H9F3
GIPDKSEDTEWSSRP

ALMS1

256

Q8TCU4
PEAVESPQEASGVRW

DPPA4

216

Q7L190
EVAKPNIGENWPTRV

AQR

521

O60306
WAEGLKSGPEEQPRD

DMAC2

236

Q9NW81
QGPLVEPAADKDWST

CCDC87

511

Q9NVE4
DSIQKDPREFGWRDP

CTNND2

536

Q9UQB3
TTSKLPTIPDWDGRE

FLRT2

401

O43155
SLTQEEAPVSWEKRP

ASXL2

571

Q76L83
EAPVSWEKRPRVTEN

ASXL2

576

Q76L83
IWTKIRVPGNDAPVE

ADAMTS12

1176

P58397
GVDPSVTDKREWRPV

ANKRD42

121

Q8N9B4
EADGKITPWPDSRDL

CNR2

341

P34972
TVRQDSPVEPWEGIS

RUBCNL

6

Q9H714
EPIGKARWPLDTDAD

PADI1

61

Q9ULC6
DDEDWQPGLVTPRKR

RAD54L

21

Q92698
DSWTPEEVIPKRLQE

P3H1

391

Q32P28
EKGNSDWPERPGLTQ

ANKRD27

996

Q96NW4
DPPWDKELAAGTESQ

NSL1

11

Q96IY1
EAREVFDLPVVKPSW

PAXIP1

61

Q6ZW49
RPTWALRPEDGEDKE

MISP

106

Q8IVT2
KTSWNIPQPGEGDVR

MTHFS

106

P49914
RAQLSPAGDPDTWKT

FAM189A1

446

O60320
TPSGEPIQSWDDIER

DCDC1

1711

M0R2J8
KPIWTRNPDDITQEE

HSP90AB1

286

P08238
PQGISWESPLDEVDK

PRKCQ

341

Q04759
PDPEVVWFKDDQSIR

MYLK

1836

Q15746
RAVSVKQREEPQDWP

MAGEC3

116

Q8TD91
SPGPTWDIKREHDVR

MAGI2

1281

Q86UL8
SKVREATNDDPWGPS

CLINT1

26

Q14677
SEDGPRPQSNWKESA

KIAA1671

1136

Q9BY89
SSGLPPGWEEKQDER

NEDD4

766

P46934
KGNEEPLSLDWPETR

SLC24A1

891

O60721
QGPERVEPDDWTSTL

INKA2

131

Q9NTI7
IFVENSPDPRKETWI

MTMR7

36

Q9Y216
SVEVTSKGRWDQPPL

KIAA1755

1081

Q5JYT7
ELAPWAADKGPQREA

SYK

326

P43405
EIKVREATSNDPWGP

EPN2

21

O95208
TWREDIRPGDPQHTK

GALNT10

506

Q86SR1
RGSPEPNITWDKDGQ

HMCN2

4056

Q8NDA2
INARGEWKTLPAPLD

MGAM

1691

O43451
DINARGEWKTLPAPL

MGAM

2586

O43451
VDAKAGWVDNTRPQP

LMTK3

1131

Q96Q04
GVKAEAPLSQRWTVP

C9orf131

756

Q5VYM1
PTWVDLKGEDSVPDT

DDX1

426

Q92499
TPTWEKTAPENGIVR

HR

11

O43593
PPISGEDNKWERESQ

CCDC88A

1021

Q3V6T2
AKRVIGDNPWTPEQL

ECPAS

226

Q5VYK3
LSIPEDAPEKDWTSR

ESF1

406

Q9H501
LNVAPPREVGEESEW

HMGXB3

401

Q12766
EESASESELWKGPLP

FRA10AC1

281

Q70Z53
SAEIRCEDGKWTEPP

F13B

311

P05160
KSQSWRQGPDREPES

KCNK17

286

Q96T54
AWPEDKRARLSVAAP

LENG9

301

Q96B70
SPIVPRNEWKALASE

PGLYRP1

31

O75594
EIWDVEDPANAGKTP

DPY19L1

631

Q2PZI1
SETPDRKWVVFDGPI

DNAH12

1606

Q6ZR08
RPSEVEKGVLPGEDW

NDST1

211

P52848
KAGNTEPVLEEWIPV

MACF1

816

O94854
RELDSITPEVLPGWK

IMMT

371

Q16891
DRVSDDIPIRTWFPK

NSMF

206

Q6X4W1
RWPRTPKEEAQSLED

MKI67

2061

P46013
EDPEWSQKDLAGPTE

PLA2G4B

346

P0C869
SREPVKAQEWDGTPG

NYAP2

571

Q9P242
GWDKIPQELSRLDQP

KIF18B

741

Q86Y91
WPARIDDIADGAVKP

HDGFL2

21

Q7Z4V5
PRWDSGLDVTPANKE

LRRC66

671

Q68CR7
SDIDLVVFGKWERPP

TENT4A

276

Q5XG87
TAQWLPDVTRPEGKD

RBBP4

46

Q09028
DPTPTIQWNRKGVDI

HMCN1

4376

Q96RW7
VPTDTTPRDRWVEKG

MORC2

831

Q9Y6X9
IEDDTALVSWKPPDG

PRTG

831

Q2VWP7
LSWQLDGKPVRPDSA

PALLD

1166

Q8WX93
PRLGKDLSEEPFDIW

ARHGAP6

721

O43182
GPDLKGQVEPWDERE

NID2

376

Q14112
WKEPQDRVPVAAAVS

PRSS36

716

Q5K4E3
SWRTEKEPLSDPVGT

ITGA5

161

P08648
LVPSDKERGLQTPVW

FUOM

81

A2VDF0
NAEPKERPTFETLRW

FRK

471

P42685
WVEVPEEDLAPGKSS

APBB3

126

O95704
WPRSKIGSDQDLGIE

HEATR5A

1591

Q86XA9
TNETWQARTGEPLPD

SLC2A11

46

Q9BYW1
RKWSSEPGPEPDTVE

KLHL11

141

Q9NVR0
SPQEGGSVDIWRIPE

CDC42EP2

141

O14613
VGLPSGPNEWLTKDD

SDR9C7

111

Q8NEX9
DPGLARWTPGKEESL

ETV7

176

Q9Y603
DTPGVDPKLISRIWV

BRCA2

2606

P51587
QDLSQPEREVDPSWG

DENND2A

126

Q9ULE3
ANGPAKEPRATLDWS

DGKI

156

O75912
DRWETKEGAASPAPE

CCDC9

366

Q9Y3X0
AEEESVPLWKRGPNV

CEP126

926

Q9P2H0
SIWNPDGIDPKELED

GLUD1

336

P00367
VPDTEKEQEWTPITG

GPAT2

416

Q6NUI2
EEPGKGSFWRIDPAS

FOXK1

371

P85037
PPLVVQRESAEEAWG

BLOC1S3

81

Q6QNY0
TAEVETREKEPPGWG

BRF2

316

Q9HAW0
WSDSRKPVILEVTPG

DNAJC13

121

O75165
PDRNKAGEWSEPVCE

IL10RB

196

Q08334
EIKVREATSNDPWGP

EPN1

21

Q9Y6I3
TDPEPTGGLASWEKL

GPR156

781

Q8NFN8
AGGPPEETLSLWKRE

ENDOV

6

Q8N8Q3
WKPRLEDGFNVALEP

ENGASE

96

Q8NFI3
RPVWDKIIEDPAQSS

EML1

576

O00423
SKIGSIPRDTPWDEN

CCDC168

2086

Q8NDH2
IWERLKEADVDPGAP

CDH7

711

Q9ULB5
APQPRAETSGKDIWH

ERCC6L2

16

Q5T890
REPKTPAPVTDWEGS

ESRG

136

Q1W209
DSWVPRVPGADKEEV

HDAC7

906

Q8WUI4
SGTAVPPDLEKLWSD

DDX46

741

Q7L014
EPDWPGRDEANKIAE

BIN1

91

O00499
KPGRADEQWRPSAEL

CACNA1H

2146

O95180
DSSPEWRSVGPAEQK

CAPN9

291

O14815
PTKVRDWNIQGLPSD

DNAH2

3361

Q9P225
QSAKERVKEWTPCGP

SAMD1

371

Q6SPF0
NTSWGDIVEEEPARP

SCAPER

506

Q9BY12
PVDRIFDDKWAPLQG

SACS

2571

Q9NZJ4
KRDWVVAPISVPENG

CDH3

106

P22223
SIWNPDGIDPKELED

GLUD2

336

P49448
WLEAAPKERGPSAAE

KBTBD6

246

Q86V97
PSEQDPEKAWGARVV

PRAP1

36

Q96NZ9
PWKAPGTVLSQEEVE

PPM1F

41

P49593
RPQSWEEVTVQFKPG

GPRASP1

1041

Q5JY77
EEGWRPLFQKTESPA

STK11IP

691

Q8N1F8
GVSPPTWTKIDNLED

USH2A

3501

O75445
PIESWPLVDRGQAKS

RAB11FIP1

611

Q6WKZ4
PELPGEIIKNTDSWA

DROSHA

331

Q9NRR4
DSPEWERTPGSAKEL

SHD

201

Q96IW2
GERVDPAVPLEKQIW

SHB

396

Q15464
DWPELKESIPVINGR

SMCHD1

1261

A6NHR9
ATWEEREESPDKPGS

TDRD6

301

O60522
EWRPEEGFVELKSPA

TSEN54

81

Q7Z6J9
EGDTPSLINWPSRVK

SVIL

291

O95425
TKVAVTPPGLAREDW

NDUFS1

606

P28331
SESWEVINSKPDERP

RETREG1

151

Q9H6L5
GEIPWSQELRPEAKN

PDPK1

496

O15530
AIPGARPKDEAQAWA

GPRASP2

116

Q96D09
TAPQGLSPQEWEADR

GAS8-AS1

81

O95177
AWENSPNVREKGSPV

PRRC2C

2256

Q9Y520
EEDPLLSPVETWKGG

ARHGAP5

1196

Q13017
QVPSVFKPTRDDRGW

SLC4A8

756

Q2Y0W8
PWKSVALEEEQEGPG

IL9R

366

Q01113
DRDAWLPGELATKPS

SSC5D

591

A1L4H1
PKAGLDPDLETRDIW

AARS2

176

Q5JTZ9
DFDPPWVEKANRTRG

RITA1

51

Q96K30
SAGEPITPDVTEKWR

ACSM3

351

Q53FZ2
DTKPERPAGWAESVL

ANGEL1

536

Q9UNK9
VKRPLDVDWTLATGP

C15orf39

151

Q6ZRI6
APPEDDNREIATWKS

CNOT1

436

A5YKK6
GGSWEVVVKPRNPDD

PNMA5

86

Q96PV4
PVKQEAEGLALDSPW

ZNF444

6

Q8N0Y2
IDGDPKWETATEAPE

ZFAT

1071

Q9P243
SIVNEKIPGVDPWES

ZNF441

91

Q8N8Z8
SIIGREDFPQKWPDL

CSE1L

116

P55060
VDDSEGSWIPPGEKE

ZNF691

56

Q5VV52
VDDPQSGELPSERWN

CDC34

101

P49427
EILEGPSPEWETKAQ

ZNF287

231

Q9HBT7
WPPRRKVSENGLEQE

MISP3

201

Q96FF7
APKRAWPSDTEIIVN

RNF208

61

Q9H0X6
LGETWKDESVPQVPA

SCN10A

1061

Q9Y5Y9
NRWDETPKTERDTPG

SF3B1

291

O75533
GLRTEEKPPFQSDWS

STYXL2

941

Q5VZP5
SAPIDPTEWVGLRKS

PIEZO2

1036

Q9H5I5
PGEFPWQASLRENKE

TMPRSS9

211

Q7Z410
IEQKNEDGTWPRGPS

USP15

211

Q9Y4E8
DELPPGWEERTTKDG

WWOX

16

Q9NZC7
NATKPSRDWGPALLE

SLC6A9

646

P48067
SEKNPEEPVRFGWVK

SLC12A3

126

P55017
ESKPEPERSGLSWSN

PRPF40B

261

Q6NWY9
EEQGPSIRNLDFWPK

UNC13B

956

O14795
GEVSWRPLVEKNPQS

UQCC1

271

Q9NVA1
VEKPLPRSSEEWRGS

TCF20

1426

Q9UGU0
LDKPIDNDAEGVWSP

TEAD4

31

Q15561
TVFVPAWRKEQSRPD

ZC3H12B

231

Q5HYM0
AWRKEQSRPDAPITD

ZC3H12B

236

Q5HYM0
EPEEWLSIARKPEAS

ZC3H12B

446

Q5HYM0
TGGERQLSPEKSEIW

POGLUT2

21

Q6UW63
RSEEGVWEENTPPLG

ZNF469

2756

Q96JG9
GEIPSSDSPEVWKVD

ZNF84

71

P51523
AVPARDPAWLQEDKV

ZNF333

171

Q96JL9
TLKEGNPPWEVTEAV

TNPO3

426

Q9Y5L0
LDKRGWDPGAEPTEA

ZSCAN22

131

P10073
WKTEPVSGEENSPDI

USP37

451

Q86T82
RKIVDIWAGPSQPSE

ZSWIM3

646

Q96MP5
EDKSGPENLLVEPWT

ZZEF1

541

O43149
VDDPQSGELPSERWN

UBE2R2

101

Q712K3
PEKRFVPDGNRISWD

KDR

166

P35968
TVFVPAWRKEQSRPD

ZC3H12C

286

Q9C0D7
TAAEKPWDAKAPEGR

ZNF831

321

Q5JPB2
LPESPKRAEEIWQQS

UBTF

481

P17480
PPEEVESRRWQKIAD

ZZZ3

671

Q8IYH5
QNLIDDGPVRPSVWK

TRPM7

1276

Q96QT4
SAQPWKGDPVEQLVR

TNS2

1186

Q63HR2
SQDLSPPDVKEEAGW

ZFTA

366

C9JLR9
RGWAPPDKSIINATD

TIMP3

196

P35625
QGPEEGEVWTKKAPR

ZAR1

221

Q86SH2
EKIPRCSWNREEPGE

nan

11

Q8N9L7
PSGIWGDSPEDIRKD

KIAA0319

126

Q5VV43
GTSNLSETEPPLWKE

LEG1

21

Q6P5S2
QLISKDWPSTEGPIE

NLRP14

231

Q86W24
IIQEESGIPKVADPW

MMUT

411

P22033
PPEAVRITSVGEDWA

MYBPC2

641

Q14324
RWIGSETDLEPPVVK

PPP1R12A

16

O14974
NSWPPSNKRGVDTED

PPP1R9A

256

Q9ULJ8