Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	phosphatidylinositol 3-kinase activator activity	IRS1 IRS2	4.96e-05	9	24	2	GO:0141038
GeneOntologyMolecularFunction	phosphatidylinositol 3-kinase regulator activity	IRS1 IRS2	2.09e-04	18	24	2	GO:0035014
GeneOntologyMolecularFunction	transmembrane receptor protein tyrosine kinase adaptor activity	IRS1 IRS2	2.09e-04	18	24	2	GO:0005068
GeneOntologyMolecularFunction	signaling adaptor activity	STAP2 IRS1 IRS2	4.83e-04	129	24	3	GO:0035591
GeneOntologyMolecularFunction	insulin receptor binding	IRS1 IRS2	5.90e-04	30	24	2	GO:0005158
GeneOntologyMolecularFunction	phosphatidylinositol 3-kinase binding	IRS1 IRS2	1.21e-03	43	24	2	GO:0043548
GeneOntologyMolecularFunction	signaling receptor complex adaptor activity	IRS1 IRS2	1.91e-03	54	24	2	GO:0030159
GeneOntologyMolecularFunction	receptor tyrosine kinase binding	IRS1 IRS2	5.20e-03	90	24	2	GO:0030971
GeneOntologyMolecularFunction	peptidase activity	TMPRSS7 MMP20 DPP6 CAPN7	7.19e-03	654	24	4	GO:0008233
GeneOntologyBiologicalProcess	polysaccharide biosynthetic process	NDST3 IRS1 IRS2	6.10e-05	76	21	3	GO:0000271
GeneOntologyBiologicalProcess	positive regulation of fatty acid beta-oxidation	IRS1 IRS2	7.65e-05	13	21	2	GO:0032000
GeneOntologyBiologicalProcess	positive regulation of glycogen biosynthetic process	IRS1 IRS2	1.50e-04	18	21	2	GO:0045725
GeneOntologyBiologicalProcess	positive regulation of fatty acid oxidation	IRS1 IRS2	2.25e-04	22	21	2	GO:0046321
GeneOntologyBiologicalProcess	regulation of fatty acid beta-oxidation	IRS1 IRS2	2.69e-04	24	21	2	GO:0031998
GeneOntologyBiologicalProcess	positive regulation of glycogen metabolic process	IRS1 IRS2	2.69e-04	24	21	2	GO:0070875
GeneOntologyBiologicalProcess	polysaccharide metabolic process	NDST3 IRS1 IRS2	2.73e-04	126	21	3	GO:0005976
GeneOntologyBiologicalProcess	glucose homeostasis	ALMS1 FOXA1 IRS1 IRS2	3.40e-04	338	21	4	GO:0042593
GeneOntologyBiologicalProcess	carbohydrate homeostasis	ALMS1 FOXA1 IRS1 IRS2	3.44e-04	339	21	4	GO:0033500
GeneOntologyBiologicalProcess	positive regulation of lipid catabolic process	IRS1 IRS2	5.11e-04	33	21	2	GO:0050996
GeneOntologyBiologicalProcess	mammary gland development	IRS1 IRS2 STAT5B	5.70e-04	162	21	3	GO:0030879
GeneOntologyBiologicalProcess	positive regulation of mesenchymal cell proliferation	IRS1 IRS2	6.09e-04	36	21	2	GO:0002053
GeneOntologyBiologicalProcess	regulation of glycogen biosynthetic process	IRS1 IRS2	6.79e-04	38	21	2	GO:0005979
GeneOntologyBiologicalProcess	regulation of glucan biosynthetic process	IRS1 IRS2	6.79e-04	38	21	2	GO:0010962
GeneOntologyBiologicalProcess	regulation of mesenchymal cell proliferation	IRS1 IRS2	9.52e-04	45	21	2	GO:0010464
GeneOntologyBiologicalProcess	regulation of fatty acid oxidation	IRS1 IRS2	9.95e-04	46	21	2	GO:0046320
GeneOntologyBiologicalProcess	regulation of polysaccharide biosynthetic process	IRS1 IRS2	1.04e-03	47	21	2	GO:0032885
GeneOntologyBiologicalProcess	positive regulation of epithelial cell migration	CAPN7 IRS1 IRS2	1.08e-03	202	21	3	GO:0010634
GeneOntologyBiologicalProcess	regulation of glycogen metabolic process	IRS1 IRS2	1.13e-03	49	21	2	GO:0070873
GeneOntologyBiologicalProcess	positive regulation of D-glucose import	IRS1 IRS2	1.17e-03	50	21	2	GO:0046326
GeneOntologyBiologicalProcess	positive regulation of fatty acid metabolic process	IRS1 IRS2	1.22e-03	51	21	2	GO:0045923
MousePheno	increased circulating hormone level	ALMS1 FOXA1 ATP4B IRS1 IRS2 STAT5B	5.90e-05	578	18	6	MP:0014456
MousePheno	increased hormone level	ALMS1 FOXA1 ATP4B IRS1 IRS2 STAT5B	1.05e-04	641	18	6	MP:0014454
MousePheno	abnormal circulating HDL cholesterol level	ALMS1 FOXA1 NDST3 IRS1 IRS2	2.27e-04	460	18	5	MP:0000184
MousePheno	increased circulating growth hormone level	FOXA1 STAT5B	2.64e-04	19	18	2	MP:0005123
MousePheno	retina photoreceptor degeneration	ALMS1 IRS2 IMPG2	3.65e-04	111	18	3	MP:0008450
MousePheno	obese	ALMS1 IRS2 STAT5B	3.84e-04	113	18	3	MP:0001261
MousePheno	increased growth hormone level	FOXA1 STAT5B	3.90e-04	23	18	2	MP:0005137
MousePheno	abnormal pancreatic beta cell morphology	ALMS1 IRS1 IRS2	4.04e-04	115	18	3	MP:0005217
MousePheno	abnormal circulating lipoprotein level	ALMS1 FOXA1 NDST3 IRS1 IRS2	4.48e-04	533	18	5	MP:0010330
MousePheno	abnormal lipoprotein level	ALMS1 FOXA1 NDST3 IRS1 IRS2	4.48e-04	533	18	5	MP:0010329
Domain	PTBI	IRS1 IRS2	8.64e-05	11	24	2	SM00310
Domain	IRS_PTB	IRS1 IRS2	1.04e-04	12	24	2	PS51064
Domain	IRS_PTB	IRS1 IRS2	1.43e-04	14	24	2	IPR002404
Domain	IRS	IRS1 IRS2	1.43e-04	14	24	2	PF02174
Domain	-	TMPRSS7 IMPG2	1.64e-04	15	24	2	3.30.70.960
Domain	SEA	TMPRSS7 IMPG2	3.60e-04	22	24	2	PF01390
Domain	SEA	TMPRSS7 IMPG2	3.94e-04	23	24	2	PS50024
Domain	SEA_dom	TMPRSS7 IMPG2	3.94e-04	23	24	2	IPR000082
Domain	PH	STAP2 IRS1 IRS2	5.24e-03	278	24	3	SM00233
Domain	PH_DOMAIN	STAP2 IRS1 IRS2	5.29e-03	279	24	3	PS50003
Domain	PH_domain	STAP2 IRS1 IRS2	5.34e-03	280	24	3	IPR001849
Domain	SH2	STAP2 STAT5B	8.72e-03	110	24	2	SM00252
Domain	SH2	STAP2 STAT5B	8.87e-03	111	24	2	PS50001
Domain	SH2	STAP2 STAT5B	9.02e-03	112	24	2	IPR000980
Domain	-	STAP2 STAT5B	9.02e-03	112	24	2	3.30.505.10
Domain	-	STAP2 IRS1 IRS2	1.33e-02	391	24	3	2.30.29.30
Pathway	REACTOME_SIGNALING_BY_LEPTIN	IRS1 IRS2 STAT5B	2.39e-07	11	17	3	M27195
Pathway	WP_FOXA2_PATHWAY	FOXA1 IRS1 IRS2	1.91e-06	21	17	3	M42579
Pathway	REACTOME_GROWTH_HORMONE_RECEPTOR_SIGNALING	IRS1 IRS2 STAT5B	2.90e-06	24	17	3	M519
Pathway	WP_EPO_RECEPTOR_SIGNALING	IRS1 IRS2 STAT5B	3.72e-06	26	17	3	M39687
Pathway	WP_EPO_RECEPTOR_SIGNALING	IRS1 IRS2 STAT5B	3.72e-06	26	17	3	MM15896
Pathway	REACTOME_INTERLEUKIN_7_SIGNALING	IRS1 IRS2 STAT5B	1.01e-05	36	17	3	M542
Pathway	REACTOME_IRS_ACTIVATION	IRS1 IRS2	1.37e-05	5	17	2	M27707
Pathway	WP_IL7_SIGNALING_PATHWAY	IRS1 IRS2 STAT5B	1.74e-05	43	17	3	MM15864
Pathway	REACTOME_SOS_MEDIATED_SIGNALLING	IRS1 IRS2	2.86e-05	7	17	2	M19489
Pathway	REACTOME_ERYTHROPOIETIN_ACTIVATES_STAT5	IRS2 STAT5B	2.86e-05	7	17	2	M27907
Pathway	WP_IL4_SIGNALING	IRS1 IRS2 STAT5B	3.48e-05	54	17	3	M39720
Pathway	PID_IL2_1PATHWAY	IRS1 IRS2 STAT5B	3.68e-05	55	17	3	M122
Pathway	REACTOME_PI3K_AKT_ACTIVATION	IRS1 IRS2	4.90e-05	9	17	2	M714
Pathway	PID_IL4_2PATHWAY	IRS1 IRS2 STAT5B	5.80e-05	64	17	3	M28
Pathway	REACTOME_SIGNAL_ATTENUATION	IRS1 IRS2	6.12e-05	10	17	2	M14236
Pathway	WP_PROLACTIN_SIGNALING	IRS1 IRS2 STAT5B	9.70e-05	76	17	3	M39601
Pathway	REACTOME_INTERLEUKIN_7_SIGNALING	IRS2 STAT5B	1.42e-04	15	17	2	MM14536
Pathway	WP_IL2_SIGNALING_PATHWAY	IRS1 IRS2 STAT5B	1.45e-04	87	17	3	MM15915
Pathway	WP_LEPTININSULIN_SIGNALING_OVERLAP	IRS1 IRS2	1.84e-04	17	17	2	M39517
Pathway	WP_LEPTININSULIN_SIGNALING_OVERLAP	IRS1 IRS2	2.57e-04	20	17	2	MM15867
Pathway	WP_TRANSCRIPTION_FACTOR_REGULATION_IN_ADIPOGENESIS	IRS1 IRS2	3.12e-04	22	17	2	M39414
Pathway	WP_ROLES_OF_CERAMIDES_IN_DEVELOPMENT_OF_INSULIN_RESISTANCE	IRS1 IRS2	3.41e-04	23	17	2	M45533
Pathway	REACTOME_SIGNALING_BY_ERYTHROPOIETIN	IRS2 STAT5B	4.04e-04	25	17	2	M27865
Pathway	SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	IRS1 IRS2	4.72e-04	27	17	2	M1718
Pathway	BIOCARTA_GH_PATHWAY	IRS1 STAT5B	4.72e-04	27	17	2	M9043
Pathway	WP_ADIPOGENESIS	IRS1 IRS2 STAT5B	4.85e-04	131	17	3	M39505
Pathway	PID_IGF1_PATHWAY	IRS1 IRS2	5.45e-04	29	17	2	M125
Pathway	WP_ADIPOGENESIS_GENES	IRS1 IRS2 STAT5B	5.53e-04	137	17	3	MM15970
Pathway	WP_BRAINDERIVED_NEUROTROPHIC_FACTOR_BDNF_SIGNALING	IRS1 IRS2 STAT5B	6.39e-04	144	17	3	M39691
Pathway	BIOCARTA_GH_PATHWAY	IRS1 STAT5B	7.07e-04	33	17	2	MM1404
Pathway	PID_EPO_PATHWAY	IRS2 STAT5B	7.07e-04	33	17	2	M233
Pathway	WP_ALPHA_6_BETA_4_SIGNALING	IRS1 IRS2	7.07e-04	33	17	2	M39503
Pathway	BIOCARTA_IL2RB_PATHWAY	IRS1 STAT5B	8.42e-04	36	17	2	MM1418
Pathway	WP_INSULIN_SIGNALING	INPP4A IRS1 IRS2	8.68e-04	160	17	3	M39482
Pathway	BIOCARTA_IL2RB_PATHWAY	IRS1 STAT5B	8.89e-04	37	17	2	M8615
Pathway	PID_RET_PATHWAY	IRS1 IRS2	9.88e-04	39	17	2	M82
Pathway	KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION	IRS1 IRS2	1.15e-03	42	17	2	M16473
Pathway	KEGG_TYPE_II_DIABETES_MELLITUS	IRS1 IRS2	1.43e-03	47	17	2	M19708
Pathway	REACTOME_IRS_MEDIATED_SIGNALLING	IRS1 IRS2	1.49e-03	48	17	2	M26916
Pathway	SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	IRS1 IRS2	1.69e-03	51	17	2	M7955
Pathway	PID_PTP1B_PATHWAY	IRS1 STAT5B	1.75e-03	52	17	2	M50
Pathway	WP_INTERFERON_TYPE_I_SIGNALING	IRS1 IRS2	1.89e-03	54	17	2	M39435
Pathway	REACTOME_SIGNALING_BY_TYPE_1_INSULIN_LIKE_GROWTH_FACTOR_1_RECEPTOR_IGF1R	IRS1 IRS2	1.89e-03	54	17	2	M27168
Pathway	REACTOME_INSULIN_RECEPTOR_SIGNALLING_CASCADE	IRS1 IRS2	1.89e-03	54	17	2	M620
Pathway	WP_ONCOSTATIN_M_SIGNALING	IRS1 STAT5B	2.72e-03	65	17	2	M39562
Pathway	WP_AGERAGE_PATHWAY	IRS1 STAT5B	2.81e-03	66	17	2	M39420
Pathway	WP_ALPHA_6_BETA_4_INTEGRIN_SIGNALING_PATHWAY	IRS1 IRS2	2.81e-03	66	17	2	MM15925
Pathway	SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	IRS1 IRS2	2.89e-03	67	17	2	M295
Pathway	KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY	IRS1 IRS2	2.89e-03	67	17	2	M10462
Pathway	WP_LEPTIN_SIGNALING	IRS1 STAT5B	3.70e-03	76	17	2	M39491
Pathway	REACTOME_SIGNALING_BY_INSULIN_RECEPTOR	IRS1 IRS2	4.30e-03	82	17	2	M1021
Pathway	REACTOME_CONSTITUTIVE_SIGNALING_BY_ABERRANT_PI3K_IN_CANCER	IRS1 IRS2	4.40e-03	83	17	2	M27163
Pathway	WP_FOCAL_ADHESION_PI3KAKTMTORSIGNALING	FOXA1 IRS1 IRS2	5.30e-03	302	17	3	M39719
Pathway	WP_FOCAL_ADHESION_PI3KAKTMTOR_SIGNALING_PATHWAY	FOXA1 IRS1 IRS2	6.55e-03	326	17	3	MM15917
Pathway	REACTOME_PI3K_AKT_SIGNALING_IN_CANCER	IRS1 IRS2	7.60e-03	110	17	2	M27162
Pathway	REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX	MMP20 CAPN7	8.14e-03	114	17	2	MM14571
Pathway	REACTOME_NEGATIVE_REGULATION_OF_THE_PI3K_AKT_NETWORK	IRS1 IRS2	8.70e-03	118	17	2	M713
Pubmed	Variations in insulin secretion in carriers of gene variants in IRS-1 and -2.	IRS1 IRS2	4.56e-07	2	24	2	11872698
Pubmed	Essential role of insulin receptor substrate 1 (IRS-1) and IRS-2 in adipocyte differentiation.	IRS1 IRS2	4.56e-07	2	24	2	11259600
Pubmed	Clearance of HCV improves insulin resistance, beta-cell function, and hepatic expression of insulin receptor substrate 1 and 2.	IRS1 IRS2	4.56e-07	2	24	2	17222321
Pubmed	Relationship of insulin receptor substrate-1 and -2 genotypes to phenotypic features of polycystic ovary syndrome.	IRS1 IRS2	4.56e-07	2	24	2	12213887
Pubmed	Association of IRS-1 and IRS-2 genes polymorphisms with polycystic ovary syndrome: a meta-analysis.	IRS1 IRS2	4.56e-07	2	24	2	22523112
Pubmed	Selective Insulin Resistance in the Kidney.	IRS1 IRS2	4.56e-07	2	24	2	27247938
Pubmed	Decreased lactation capacity and altered milk composition in insulin receptor substrate null mice is associated with decreased maternal body mass and reduced insulin-dependent phosphorylation of mammary Akt.	IRS1 IRS2	4.56e-07	2	24	2	17641282
Pubmed	Night-Shift Work Duration and Risk of Colorectal Cancer According to IRS1 and IRS2 Expression.	IRS1 IRS2	4.56e-07	2	24	2	31666286
Pubmed	Insulin receptor substrate-1/2 mediates IL-4-induced migration of human airway epithelial cells.	IRS1 IRS2	4.56e-07	2	24	2	19447894
Pubmed	Differential involvement of insulin receptor substrate (IRS)-1 and IRS-2 in brain insulin signaling is associated with the effects on amyloid pathology in a mouse model of Alzheimer's disease.	IRS1 IRS2	4.56e-07	2	24	2	34537327
Pubmed	Association of Gly972Arg variant of insulin receptor subtrate-1 and Gly1057Asp variant of insulin receptor subtrate-2 with polycystic ovary syndrome in the Chinese population.	IRS1 IRS2	4.56e-07	2	24	2	25310961
Pubmed	Divergent roles for IRS-1 and IRS-2 in breast cancer metastasis.	IRS1 IRS2	4.56e-07	2	24	2	17361103
Pubmed	Disruption of IRS-2 causes type 2 diabetes in mice.	IRS1 IRS2	4.56e-07	2	24	2	9495343
Pubmed	Phosphorylation of insulin receptor substrates (IRS-1 and IRS-2) is attenuated following cecal ligation and puncture in mice.	IRS1 IRS2	4.56e-07	2	24	2	37550630
Pubmed	Insulin receptor substrate 1, but not IRS2, plays a dominant role in regulating pancreatic alpha cell function in mice.	IRS1 IRS2	4.56e-07	2	24	2	33839150
Pubmed	Roles of Insulin Receptor Substrates (IRS) in renal function and renal hemodynamics.	IRS1 IRS2	4.56e-07	2	24	2	33270683
Pubmed	Insulin Receptor Substrate Adaptor Proteins Mediate Prognostic Gene Expression Profiles in Breast Cancer.	IRS1 IRS2	4.56e-07	2	24	2	26991655
Pubmed	Overexpression of IRS2 in isolated pancreatic islets causes proliferation and protects human beta-cells from hyperglycemia-induced apoptosis.	IRS1 IRS2	4.56e-07	2	24	2	15572028
Pubmed	Association of IRS-1 and IRS-2 polymorphisms with predisposition to type-2 diabetes (T2D): a meta-analysis and trial sequential analysis.	IRS1 IRS2	4.56e-07	2	24	2	37173295
Pubmed	Insulin receptor substrates are essential for the bioenergetic and hypertrophic response of the heart to exercise training.	IRS1 IRS2	4.56e-07	2	24	2	25002528
Pubmed	Targeting type 2 diabetes: lessons from a knockout model of insulin receptor substrate 2.	IRS1 IRS2	4.56e-07	2	24	2	24977713
Pubmed	Down-regulation of Insulin Receptor Substrate 1 during Hyperglycemia Induces Vascular Smooth Muscle Cell Dedifferentiation.	IRS1 IRS2	4.56e-07	2	24	2	28003360
Pubmed	Roles of insulin receptor substrates in insulin-induced stimulation of renal proximal bicarbonate absorption.	IRS1 IRS2	4.56e-07	2	24	2	15975995
Pubmed	Systematic modeling for the insulin signaling network mediated by IRS(1) and IRS(2).	IRS1 IRS2	4.56e-07	2	24	2	24703981
Pubmed	Differential hepatic distribution of insulin receptor substrates causes selective insulin resistance in diabetes and obesity.	IRS1 IRS2	4.56e-07	2	24	2	27708333
Pubmed	Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory beta-cell hyperplasia.	IRS1 IRS2	4.56e-07	2	24	2	11078455
Pubmed	PDGF-induced vascular smooth muscle cell proliferation is associated with dysregulation of insulin receptor substrates.	IRS1 IRS2	4.56e-07	2	24	2	21325637
Pubmed	Oncogenic transformation by the signaling adaptor proteins insulin receptor substrate (IRS)-1 and IRS-2.	IRS1 IRS2	4.56e-07	2	24	2	17374994
Pubmed	Impairment of bone healing by insulin receptor substrate-1 deficiency.	IRS1 IRS2	4.56e-07	2	24	2	14736890
Pubmed	Irs1 and Irs2 signaling is essential for hepatic glucose homeostasis and systemic growth.	IRS1 IRS2	4.56e-07	2	24	2	16374520
Pubmed	Study of association of IRS-1 and IRS-2 genes polymorphisms with clinical and metabolic features in women with polycystic ovary syndrome. Is there an impact?	IRS1 IRS2	4.56e-07	2	24	2	20210696
Pubmed	Evidence for lifespan extension and delayed age-related biomarkers in insulin receptor substrate 1 null mice.	IRS1 IRS2	4.56e-07	2	24	2	17928362
Pubmed	Developmental and hormonal signals dramatically alter the localization and abundance of insulin receptor substrate proteins in the mammary gland.	IRS1 IRS2	4.56e-07	2	24	2	12746333
Pubmed	Prevalence of the insulin receptor substrate-1(IRS-1) Gly972Arg and the insulin receptor substrate-2(IRS-2) Gly1057Asp polymorphisms in PCOS patients and non-diabetic healthy women.	IRS1 IRS2	4.56e-07	2	24	2	22205343
Pubmed	Impaired insulin signaling in endothelial cells reduces insulin-induced glucose uptake by skeletal muscle.	IRS1 IRS2	4.56e-07	2	24	2	21356519
Pubmed	Insulin receptor substrates 1 and 2 but not Shc can activate the insulin receptor independent of insulin and induce proliferation in CHO-IR cells.	IRS1 IRS2	4.56e-07	2	24	2	17222824
Pubmed	The study on the relationship between IRS-1 Gly972Arg and IRS-2 Gly1057Asp polymorphisms and type 2 diabetes in the Kurdish ethnic group in West Iran.	IRS1 IRS2	4.56e-07	2	24	2	22994406
Pubmed	Insulin Receptor Substrate-1 (IRS-1) and IRS-2 expression levels are associated with prognosis in non-small cell lung cancer (NSCLC).	IRS1 IRS2	4.56e-07	2	24	2	31393907
Pubmed	Myocardial loss of IRS1 and IRS2 causes heart failure and is controlled by p38α MAPK during insulin resistance.	IRS1 IRS2	4.56e-07	2	24	2	24159000
Pubmed	Inhibition of TNF-α improves the bladder dysfunction that is associated with type 2 diabetes.	IRS1 IRS2	4.56e-07	2	24	2	22688336
Pubmed	Caspase-mediated Cleavage of Insulin Receptor Substrate.	IRS1 IRS2	4.56e-07	2	24	2	15069074
Pubmed	Dysregulation of insulin receptor substrate 2 in beta cells and brain causes obesity and diabetes.	IRS1 IRS2	4.56e-07	2	24	2	15467829
Pubmed	The Irs1 branch of the insulin signaling cascade plays a dominant role in hepatic nutrient homeostasis.	IRS1 IRS2	4.56e-07	2	24	2	19596788
Pubmed	Polymorphism analysis of the Gly972Arg IRS-1 and Gly1057Asp IRS-2 genes in obese pregnant women.	IRS1 IRS2	4.56e-07	2	24	2	32540195
Pubmed	Insulin receptor substrate (IRS)-2, not IRS-1, protects human neuroblastoma cells against apoptosis.	IRS1 IRS2	4.56e-07	2	24	2	19259821
Pubmed	The double life of Irs.	IRS1 IRS2	4.56e-07	2	24	2	18590687
Pubmed	Lack of insulin receptor substrate-2 causes progressive neointima formation in response to vessel injury.	IRS1 IRS2	4.56e-07	2	24	2	12810606
Pubmed	Dynamic functional relay between insulin receptor substrate 1 and 2 in hepatic insulin signaling during fasting and feeding.	IRS1 IRS2	4.56e-07	2	24	2	18590692
Pubmed	Overexpression of insulin receptor substrate-1, but not insulin receptor substrate-2, protects a T cell hybridoma from activation-induced cell death.	IRS1 IRS2	4.56e-07	2	24	2	12055235
Pubmed	Mammary tumorigenesis and metastasis caused by overexpression of insulin receptor substrate 1 (IRS-1) or IRS-2.	IRS1 IRS2	4.56e-07	2	24	2	17030631
Pubmed	Role of allelic variants Gly972Arg of IRS-1 and Gly1057Asp of IRS-2 in moderate-to-severe insulin resistance of women with polycystic ovary syndrome.	IRS1 IRS2	4.56e-07	2	24	2	11522686
Pubmed	Association of IRS1 (Gly972Arg) and IRS2 (Gly1057Asp) genes polymorphisms with OSA and NAFLD in Asian Indians.	IRS1 IRS2	4.56e-07	2	24	2	34449768
Pubmed	Insulin receptor substrate 2 is essential for maturation and survival of photoreceptor cells.	IRS1 IRS2	4.56e-07	2	24	2	15689562
Pubmed	Irs1 serine 307 promotes insulin sensitivity in mice.	IRS1 IRS2	4.56e-07	2	24	2	20074531
Pubmed	Role of IRS-2 in insulin and cytokine signalling.	IRS1 IRS2	4.56e-07	2	24	2	7675087
Pubmed	Selective insulin resistance with differential expressions of IRS-1 and IRS-2 in human NAFLD livers.	IRS1 IRS2	4.56e-07	2	24	2	29717275
Pubmed	Increased expression of the sterol regulatory element-binding protein-1 gene in insulin receptor substrate-2(-/-) mouse liver.	IRS1 IRS2	4.56e-07	2	24	2	11546755
Pubmed	Increased insulin resistance in obese children who have both 972 IRS-1 and 1057 IRS-2 polymorphisms.	IRS1 IRS2	4.56e-07	2	24	2	12475767
Pubmed	Association of insulin receptor H1085H C>T, insulin receptor substrate 1 G972R and insulin receptor substrate 2 1057G/A polymorphisms with refractory temporal lobe epilepsy in Han Chinese.	IRS1 IRS2	1.37e-06	3	24	2	25458098
Pubmed	Structural insights into suppressor of cytokine signaling 1 protein- identification of new leads for type 2 diabetes mellitus.	IRS1 IRS2	1.37e-06	3	24	2	29630758
Pubmed	Aflatoxin B1 induces Src phosphorylation and stimulates lung cancer cell migration.	IRS1 IRS2	1.37e-06	3	24	2	25820822
Pubmed	Cloning and characterization of PHIP, a novel insulin receptor substrate-1 pleckstrin homology domain interacting protein.	IRS1 IRS2	1.37e-06	3	24	2	11018022
Pubmed	Inhibition of PTP1B restores IRS1-mediated hepatic insulin signaling in IRS2-deficient mice.	IRS1 IRS2	1.37e-06	3	24	2	20028942
Pubmed	Associations of insulin receptor and insulin receptor substrates genetic polymorphisms with polycystic ovary syndrome: A systematic review and meta-analysis.	IRS1 IRS2	1.37e-06	3	24	2	27098445
Pubmed	Insulin receptor substrates differentially exacerbate insulin-mediated left ventricular remodeling.	IRS1 IRS2	1.37e-06	3	24	2	32213702
Pubmed	Modulation of insulin signal transduction by eutopic overexpression of the receptor-type protein-tyrosine phosphatase LAR.	IRS1 IRS2	1.37e-06	3	24	2	8732688
Pubmed	MicroRNA-7 Regulates Insulin Signaling Pathway by Targeting IRS1, IRS2, and RAF1 Genes in Gestational Diabetes Mellitus.	IRS1 IRS2	1.37e-06	3	24	2	35422233
Pubmed	Insulin receptor substrate signaling suppresses neonatal autophagy in the heart.	IRS1 IRS2	1.37e-06	3	24	2	24177427
Pubmed	Role of insulin receptor substrates and protein kinase C-zeta in vascular permeability factor/vascular endothelial growth factor expression in pancreatic cancer cells.	IRS1 IRS2	1.37e-06	3	24	2	14604996
Pubmed	Tamoxifen reduces fat mass by boosting reactive oxygen species.	IRS1 IRS2	1.37e-06	3	24	2	25569103
Pubmed	Targeted gene mutations define the roles of insulin and IGF-I receptors in mouse embryonic development.	IRS1 IRS2	1.37e-06	3	24	2	10417963
Pubmed	SH2B1 enhances insulin sensitivity by both stimulating the insulin receptor and inhibiting tyrosine dephosphorylation of insulin receptor substrate proteins.	IRS1 IRS2	1.37e-06	3	24	2	19542202
Pubmed	The proto-oncogene product c-Crk associates with insulin receptor substrate-1 and 4PS. Modulation by insulin growth factor-I (IGF) and enhanced IGF-I signaling.	IRS1 IRS2	1.37e-06	3	24	2	8621590
Pubmed	Glucose effects on beta-cell growth and survival require activation of insulin receptors and insulin receptor substrate 2.	IRS1 IRS2	1.37e-06	3	24	2	19273608
Pubmed	The insulin-like growth factor-1 pathway mediator genes: SHC1 Met300Val shows a protective effect in breast cancer.	IRS1 IRS2	1.37e-06	3	24	2	15308584
Pubmed	Insulin signaling and glucose homeostasis in mice lacking protein tyrosine phosphatase alpha.	IRS1 IRS2	1.37e-06	3	24	2	14733908
Pubmed	The type I interferon receptor mediates tyrosine phosphorylation of insulin receptor substrate 2.	IRS1 IRS2	1.37e-06	3	24	2	8550573
Pubmed	Study on insulin resistance and genetic polymorphisms in essential hypertension patients of two different kinds of TCM constitution.	IRS1 IRS2	1.37e-06	3	24	2	17898946
Pubmed	Insulin receptor isoforms A and B as well as insulin receptor substrates-1 and -2 are differentially expressed in prostate cancer.	IRS1 IRS2	1.37e-06	3	24	2	23251408
Pubmed	Polymorphisms of the insulin receptor and the insulin receptor substrates genes in polycystic ovary syndrome: a Mendelian randomization meta-analysis.	IRS1 IRS2	1.37e-06	3	24	2	19926323
Pubmed	Cellular growth inhibition by TGF-beta1 involves IRS proteins.	IRS1 IRS2	1.37e-06	3	24	2	15135063
Pubmed	Insulin receptor substrate 2 is required for testicular development.	IRS1 IRS2	1.37e-06	3	24	2	23741292
Pubmed	Tissue-specific insulin resistance in mice with mutations in the insulin receptor, IRS-1, and IRS-2.	IRS1 IRS2	1.37e-06	3	24	2	10642598
Pubmed	Estrogen receptor-alpha regulates the degradation of insulin receptor substrates 1 and 2 in breast cancer cells.	IRS1 IRS2	1.37e-06	3	24	2	12821935
Pubmed	Inappropriate activation of the TSC/Rheb/mTOR/S6K cassette induces IRS1/2 depletion, insulin resistance, and cell survival deficiencies.	IRS1 IRS2	1.37e-06	3	24	2	15380067
Pubmed	The double-stranded RNA-dependent protein kinase differentially regulates insulin receptor substrates 1 and 2 in HepG2 cells.	IRS1 IRS2	1.37e-06	3	24	2	20685959
Pubmed	The cross-talk between angiotensin and insulin differentially affects phosphatidylinositol 3-kinase- and mitogen-activated protein kinase-mediated signaling in rat heart: implications for insulin resistance.	IRS1 IRS2	1.37e-06	3	24	2	12960006
Pubmed	Glucokinase and IRS-2 are required for compensatory beta cell hyperplasia in response to high-fat diet-induced insulin resistance.	IRS1 IRS2	1.37e-06	3	24	2	17200721
Pubmed	Physical and functional interactions between STAP-2/BKS and STAT5.	STAP2 STAT5B	1.37e-06	3	24	2	15611091
Pubmed	Insulin signaling and reduced glucocorticoid receptor activity attenuate postprandial gene expression in liver.	IRS1 IRS2	1.37e-06	3	24	2	30532187
Pubmed	Decreased IGF type 1 receptor signaling in mammary epithelium during pregnancy leads to reduced proliferation, alveolar differentiation, and expression of insulin receptor substrate (IRS)-1 and IRS-2.	IRS1 IRS2	1.37e-06	3	24	2	21628386
Pubmed	Inactivation of hepatic Foxo1 by insulin signaling is required for adaptive nutrient homeostasis and endocrine growth regulation.	IRS1 IRS2	1.37e-06	3	24	2	18590693
Pubmed	The direct involvement of SirT1 in insulin-induced insulin receptor substrate-2 tyrosine phosphorylation.	IRS1 IRS2	1.37e-06	3	24	2	17901049
Pubmed	Differential involvement of the microtubule cytoskeleton in insulin receptor substrate 1 (IRS-1) and IRS-2 signaling to AKT determines the response to microtubule disruption in breast carcinoma cells.	IRS1 IRS2	1.37e-06	3	24	2	28320862
Pubmed	Hepatitis C virus infection in vitro triggers endoplasmic reticulum stress and downregulates insulin receptor substrates 1 and 2 through upregulation of cytokine signaling suppressor 3.	IRS1 IRS2	1.37e-06	3	24	2	25283858
Pubmed	Characterization of Drosophila insulin receptor substrate.	IRS1 IRS2	1.37e-06	3	24	2	10801879
Pubmed	Selective alterations in insulin receptor substrates-1, -2 and -4 in theca but not granulosa cells from polycystic ovaries.	IRS1 IRS2	1.37e-06	3	24	2	15155816
Pubmed	DPP-4 Inhibitor Sitagliptin Improves Cardiac Function and Glucose Homeostasis and Ameliorates β-Cell Dysfunction Together with Reducing S6K1 Activation and IRS-1 and IRS-2 Degradation in Obesity Female Mice.	IRS1 IRS2	1.37e-06	3	24	2	30116740
Pubmed	IRS-2 Partially Compensates for the Insulin Signal Defects in IRS-1-/- Mice Mediated by miR-33.	IRS1 IRS2	1.37e-06	3	24	2	28190325
Pubmed	Multiple forms of p55PIK, a regulatory subunit of phosphoinositide 3-kinase, are generated by alternative initiation of translation.	IRS1 IRS2	1.37e-06	3	24	2	10417350
Interaction	JAK3 interactions	IRS1 IRS2 STAT5B GPATCH8	1.59e-05	136	23	4	int:JAK3
Interaction	JAK2 interactions	STAP2 IRS1 IRS2 STAT5B	3.40e-05	165	23	4	int:JAK2
Cytoband	13q34	ATP4B IRS2	3.69e-04	54	24	2	13q34
Cytoband	Ensembl 112 genes in cytogenetic band chr13q34	ATP4B IRS2	9.75e-04	88	24	2	chr13q34
ToppCell	TCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-1\|TCGA-Pancreas / Sample_Type by Project: Shred V9	ALMS1 HMCN1 IRS1 PBRM1	2.82e-06	186	24	4	03db813598b67b1e08f759758a1c2023396921fa
Disease	amnestic disorder (implicated_via_orthology)	IRS1 IRS2	1.90e-05	9	22	2	DOID:10914 (implicated_via_orthology)
Disease	intellectual disability (implicated_via_orthology)	NDST3 IRS1 IRS2	2.35e-05	75	22	3	DOID:1059 (implicated_via_orthology)
Disease	type 2 diabetes mellitus (implicated_via_orthology)	ALMS1 IRS1 IRS2	6.42e-05	105	22	3	DOID:9352 (implicated_via_orthology)
Disease	osteoporosis (biomarker_via_orthology)	IRS1 IRS2	1.21e-04	22	22	2	DOID:11476 (biomarker_via_orthology)
Disease	TYPE 2 DIABETES MELLITUS	IRS1 IRS2	1.98e-04	28	22	2	125853
Disease	Type 2 diabetes mellitus	IRS1 IRS2	1.98e-04	28	22	2	cv:C0011860
Disease	glucose metabolism disease (implicated_via_orthology)	IRS1 IRS2	1.98e-04	28	22	2	DOID:4194 (implicated_via_orthology)
Disease	Breast adenocarcinoma	FOXA1 PBRM1	4.28e-04	41	22	2	C0858252
Disease	Neoplasm of uncertain or unknown behavior of breast	FOXA1 PBRM1	4.28e-04	41	22	2	C0496956
Disease	obesity (implicated_via_orthology)	ALMS1 ATP4B IRS1	5.30e-04	215	22	3	DOID:9970 (implicated_via_orthology)
Disease	Insulin Sensitivity	IRS1 IRS2	9.15e-04	60	22	2	C0920563
Disease	Insulin Resistance	IRS1 IRS2	9.15e-04	60	22	2	C0021655
Disease	non-alcoholic fatty liver disease (biomarker_via_orthology)	IRS1 IRS2	1.07e-03	65	22	2	DOID:0080208 (biomarker_via_orthology)
Disease	stomach cancer (is_implicated_in)	FOXA1 ATP4B	1.31e-03	72	22	2	DOID:10534 (is_implicated_in)
Disease	alcohol consumption measurement	ALMS1 NDST3 ZC3H4 DPP6 IMPG2	1.90e-03	1242	22	5	EFO_0007878
Disease	lean body mass	SLC44A2 ZC3H4 DPP6	2.70e-03	379	22	3	EFO_0004995
Disease	Alloxan Diabetes	IRS1 IRS2	2.92e-03	108	22	2	C0002152
Disease	Streptozotocin Diabetes	IRS1 IRS2	2.92e-03	108	22	2	C0038433
Disease	Diabetes Mellitus, Experimental	IRS1 IRS2	2.92e-03	108	22	2	C0011853

Protein segments in the cluster

Peptide	Gene	Start	Entry
KAHYVTPKFYPEGTG	ARSH	446	Q5FYA8
LPYKPSGSTKMYYVP	ALMS1	3266	Q8TCU4
PYYGKKAQPHYSNPL	ATP4B	231	P51164
KIPPYHGPYYQTLAE	ARMCX5	266	Q6P1M9
THTIFYKEYPGGPKE	NDST3	481	O95803
YPAAPVYSYFKPPDK	RBM18	161	Q96H35
PPTPKFHSYLEGYIY	ARHGAP39	816	Q9C0H5
FPKHYRPPEGTYGKV	INPP4A	961	Q96PE3
EPFYHLPSKKKYPDY	PBRM1	406	Q86U86
PEYYHYIPPAHCKVK	GPATCH8	391	Q9UKJ3
PYAVNPDHYTPYKTL	POMGNT2	366	Q8NAT1
YGPEDPQHKPVLSYY	IRS1	751	P35568
PVKYYPHRKPYGIWN	HMCN1	376	Q96RW7
TFKRSYPHAKPPYSY	FOXA1	161	P55317
PKVAYHPYPEDYGDI	IRS2	621	Q9Y4H2
YKTDGKKVYYPADPP	CAPN7	611	Q9Y6W3
PHYYGKHGTPQKYDP	SLC44A2	6	Q8IWA5
YTGSIYPTVKPYHYP	DPP6	331	P42658
YPTVKPYHYPKAGSE	DPP6	336	P42658
PTYKYKNPYGFHLPK	MMP20	246	O60882
PKPKGVLPSHYYESF	STAP2	11	Q9UGK3
PDRPKDEVYSKYYTP	STAT5B	671	P51692
EKYEGPYPQHPFYSS	IMPG2	1171	Q9BZV3
ISSPYYPSYYPPKCK	TMPRSS7	381	Q7RTY8
GHRKYREYSPPYAPS	ZC3H4	151	Q9UPT8
TYYPSPGAYNPEKKP	PIFO	126	Q8TCI5