Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	transmembrane signaling receptor activity	FZD1 FZD6 S1PR5 ANTXRL IL17RE TAS1R3 CD300H OR52H1 L1CAM C5AR2 GPR37L1 ADGRE5 CHRNA10 CHRNA2 CHRNA4 PTH1R	2.86e-05	1353	74	16	GO:0004888
GeneOntologyMolecularFunction	acetylcholine-gated monoatomic cation-selective channel activity	CHRNA10 CHRNA2 CHRNA4	3.20e-05	17	74	3	GO:0022848
GeneOntologyMolecularFunction	ligand-gated monoatomic cation channel activity	KCNN2 CHRNA10 CHRNA2 CHRNA4 RYR2	1.72e-04	140	74	5	GO:0099094
GeneOntologyMolecularFunction	gated channel activity	KCNB1 KCNN2 CHRNA10 KCNB2 CHRNA2 CHRNA4 RYR2	2.37e-04	334	74	7	GO:0022836
GeneOntologyMolecularFunction	monoatomic cation channel activity	KCNB1 KCNN2 CHRNA10 KCNB2 CHRNA2 CHRNA4 RYR2	2.78e-04	343	74	7	GO:0005261
GeneOntologyMolecularFunction	transmembrane transporter activity	SLC36A1 KCNB1 SLC39A1 SLC22A14 KCNN2 SLC38A11 CHRNA10 KCNB2 SLC7A7 CHRNA2 CHRNA4 SLC2A1 RYR2	3.61e-04	1180	74	13	GO:0022857
GeneOntologyMolecularFunction	excitatory extracellular ligand-gated monoatomic ion channel activity	CHRNA10 CHRNA2 CHRNA4	5.42e-04	43	74	3	GO:0005231
GeneOntologyMolecularFunction	ligand-gated monoatomic ion channel activity	KCNN2 CHRNA10 CHRNA2 CHRNA4 RYR2	7.52e-04	193	74	5	GO:0015276
GeneOntologyMolecularFunction	monoatomic cation transmembrane transporter activity	SLC36A1 KCNB1 SLC39A1 KCNN2 CHRNA10 KCNB2 CHRNA2 CHRNA4 RYR2	7.57e-04	664	74	9	GO:0008324
GeneOntologyMolecularFunction	ligand-gated channel activity	KCNN2 CHRNA10 CHRNA2 CHRNA4 RYR2	8.25e-04	197	74	5	GO:0022834
GeneOntologyMolecularFunction	transporter activity	SLC36A1 KCNB1 SLC39A1 SLC22A14 KCNN2 SLC38A11 CHRNA10 KCNB2 SLC7A7 CHRNA2 CHRNA4 SLC2A1 RYR2	8.30e-04	1289	74	13	GO:0005215
GeneOntologyMolecularFunction	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	CHRNA10 CHRNA2 CHRNA4	1.24e-03	57	74	3	GO:1904315
GeneOntologyMolecularFunction	neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential	CHRNA10 CHRNA2 CHRNA4	1.44e-03	60	74	3	GO:0099529
GeneOntologyMolecularFunction	monoatomic ion channel activity	KCNB1 KCNN2 CHRNA10 KCNB2 CHRNA2 CHRNA4 RYR2	1.55e-03	459	74	7	GO:0005216
GeneOntologyMolecularFunction	Wnt receptor activity	FZD1 FZD6	1.78e-03	17	74	2	GO:0042813
GeneOntologyMolecularFunction	transmitter-gated channel activity	CHRNA10 CHRNA2 CHRNA4	1.81e-03	65	74	3	GO:0022835
GeneOntologyMolecularFunction	transmitter-gated monoatomic ion channel activity	CHRNA10 CHRNA2 CHRNA4	1.81e-03	65	74	3	GO:0022824
GeneOntologyMolecularFunction	L-amino acid transmembrane transporter activity	SLC36A1 SLC38A11 SLC7A7	2.33e-03	71	74	3	GO:0015179
GeneOntologyMolecularFunction	monoatomic ion transmembrane transporter activity	SLC36A1 KCNB1 SLC39A1 KCNN2 CHRNA10 KCNB2 CHRNA2 CHRNA4 RYR2	2.58e-03	793	74	9	GO:0015075
GeneOntologyMolecularFunction	postsynaptic neurotransmitter receptor activity	CHRNA10 CHRNA2 CHRNA4	2.72e-03	75	74	3	GO:0098960
GeneOntologyMolecularFunction	extracellular ligand-gated monoatomic ion channel activity	CHRNA10 CHRNA2 CHRNA4	2.94e-03	77	74	3	GO:0005230
GeneOntologyMolecularFunction	acetylcholine receptor activity	CHRNA2 CHRNA4	3.26e-03	23	74	2	GO:0015464
GeneOntologyMolecularFunction	channel activity	KCNB1 KCNN2 CHRNA10 KCNB2 CHRNA2 CHRNA4 RYR2	3.29e-03	525	74	7	GO:0015267
GeneOntologyMolecularFunction	passive transmembrane transporter activity	KCNB1 KCNN2 CHRNA10 KCNB2 CHRNA2 CHRNA4 RYR2	3.32e-03	526	74	7	GO:0022803
GeneOntologyMolecularFunction	organic anion transmembrane transporter activity	SLC36A1 SLC22A14 SLC38A11 SLC7A7 SLC2A1	4.64e-03	293	74	5	GO:0008514
GeneOntologyMolecularFunction	delayed rectifier potassium channel activity	KCNB1 KCNB2	4.81e-03	28	74	2	GO:0005251
GeneOntologyCellularComponent	acetylcholine-gated channel complex	CHRNA10 CHRNA2 CHRNA4	3.34e-05	18	74	3	GO:0005892
GeneOntologyCellularComponent	cholinergic synapse	KCNB1 CHRNA10 CHRNA4	6.25e-05	22	74	3	GO:0098981
GeneOntologyCellularComponent	cell surface	FZD1 FZD6 ANTXRL KCNB1 CIITA L1CAM KCNN2 DUOX2 ADGRE5 CD200R1L CHRNA4 MOG	4.96e-04	1111	74	12	GO:0009986
GeneOntologyCellularComponent	sarcolemma	KCNB1 KCNN2 SMPD4 SLC2A1 RYR2	5.71e-04	190	74	5	GO:0042383
GeneOntologyCellularComponent	receptor complex	TAS1R3 GPR37L1 TLR7 CHRNA10 CD200R1L CHRNA2 CHRNA4 PTH1R	1.02e-03	581	74	8	GO:0043235
GeneOntologyCellularComponent	apical part of cell	FZD6 SLC36A1 KCNB1 C5AR2 DUOX2 PATJ SLC2A1 PTH1R	1.15e-03	592	74	8	GO:0045177
Domain	K_chnl_volt-dep_Kv2	KCNB1 KCNB2	1.59e-05	2	75	2	IPR003973
Domain	Kv2channel	KCNB1 KCNB2	1.59e-05	2	75	2	PF03521
Domain	Nicotinic_acetylcholine_rcpt	CHRNA10 CHRNA2 CHRNA4	3.35e-05	16	75	3	IPR002394
Domain	GPCR_2_secretin-like	FZD1 FZD6 ADGRE5 PTH1R	9.86e-05	60	75	4	IPR000832
Domain	GPCR_2-like	FZD1 FZD6 ADGRE5 PTH1R	9.86e-05	60	75	4	IPR017981
Domain	-	CHRNA10 CHRNA2 CHRNA4	1.04e-04	23	75	3	1.20.120.370
Domain	Acetylcholine_rcpt_TM	CHRNA10 CHRNA2 CHRNA4	1.04e-04	23	75	3	IPR027361
Domain	G_PROTEIN_RECEP_F2_4	FZD1 FZD6 ADGRE5 PTH1R	1.05e-04	61	75	4	PS50261
Domain	Haem_peroxidase	MPO DUOX2	7.01e-04	10	75	2	IPR010255
Domain	An_peroxidase	MPO DUOX2	7.01e-04	10	75	2	PF03098
Domain	PEROXIDASE_3	MPO DUOX2	7.01e-04	10	75	2	PS50292
Domain	Haem_peroxidase_animal	MPO DUOX2	7.01e-04	10	75	2	IPR019791
Domain	-	MPO DUOX2	7.01e-04	10	75	2	1.10.640.10
Domain	Neurotransmitter_ion_chnl_CS	CHRNA10 CHRNA2 CHRNA4	7.82e-04	45	75	3	IPR018000
Domain	Neur_chan_memb	CHRNA10 CHRNA2 CHRNA4	8.34e-04	46	75	3	PF02932
Domain	Frizzled	FZD1 FZD6	8.55e-04	11	75	2	IPR000539
Domain	Frizzled	FZD1 FZD6	8.55e-04	11	75	2	PF01534
Domain	Frizzled	FZD1 FZD6	8.55e-04	11	75	2	SM01330
Domain	Neur_chan_LBD	CHRNA10 CHRNA2 CHRNA4	8.88e-04	47	75	3	PF02931
Domain	NEUROTR_ION_CHANNEL	CHRNA10 CHRNA2 CHRNA4	8.88e-04	47	75	3	PS00236
Domain	Neurotrans-gated_channel_TM	CHRNA10 CHRNA2 CHRNA4	8.88e-04	47	75	3	IPR006029
Domain	-	CHRNA10 CHRNA2 CHRNA4	8.88e-04	47	75	3	2.70.170.10
Domain	Neur_channel	CHRNA10 CHRNA2 CHRNA4	8.88e-04	47	75	3	IPR006201
Domain	Neur_chan_lig-bd	CHRNA10 CHRNA2 CHRNA4	8.88e-04	47	75	3	IPR006202
Domain	Inhibin_asu	INHA GDF1	1.21e-03	13	75	2	IPR002405
Domain	Bbox_C	TRIM67 TRIM28	1.62e-03	15	75	2	IPR003649
Domain	BBC	TRIM67 TRIM28	1.62e-03	15	75	2	SM00502
Domain	Frizzled/SFRP	FZD1 FZD6	1.84e-03	16	75	2	IPR015526
Domain	Aa_trans	SLC36A1 SLC38A11	2.08e-03	17	75	2	PF01490
Domain	AA_transpt_TM	SLC36A1 SLC38A11	2.08e-03	17	75	2	IPR013057
Domain	FRI	FZD1 FZD6	2.88e-03	20	75	2	SM00063
Domain	-	FZD1 FZD6	3.18e-03	21	75	2	1.10.2000.10
Domain	Frizzled_dom	FZD1 FZD6	4.15e-03	24	75	2	IPR020067
Domain	FZ	FZD1 FZD6	4.15e-03	24	75	2	PS50038
Domain	Fz	FZD1 FZD6	4.15e-03	24	75	2	PF01392
Domain	EGF_CA	MEGF8 FAT3 ADGRE5	5.01e-03	86	75	3	PF07645
Domain	K_chnl_volt-dep_Kv	KCNB1 KCNB2	5.23e-03	27	75	2	IPR003968
Domain	ZF_RING_1	RNF144B UBR2 TRIM67 TRIM28 RNF138	6.30e-03	291	75	5	PS00518
Domain	ZF_RING_2	RNF144B UBR2 TRIM67 TRIM28 RNF138	6.95e-03	298	75	5	PS50089
Domain	EGF_Ca-bd_CS	MEGF8 FAT3 ADGRE5	7.00e-03	97	75	3	IPR018097
Domain	TGF-beta-rel	INHA GDF1	7.30e-03	32	75	2	IPR015615
Domain	TGFb_CS	INHA GDF1	7.30e-03	32	75	2	IPR017948
Domain	EGF_CA	MEGF8 FAT3 ADGRE5	7.40e-03	99	75	3	PS01187
Domain	ASX_HYDROXYL	MEGF8 FAT3 ADGRE5	7.61e-03	100	75	3	PS00010
Domain	RING	RNF144B UBR2 TRIM67 TRIM28 RNF138	7.64e-03	305	75	5	SM00184
Domain	VG_K_chnl	KCNB1 KCNB2	7.75e-03	33	75	2	IPR028325
Domain	GPCR_2_secretin-like_CS	ADGRE5 PTH1R	8.21e-03	34	75	2	IPR017983
Domain	EGF-type_Asp/Asn_hydroxyl_site	MEGF8 FAT3 ADGRE5	8.93e-03	106	75	3	IPR000152
Domain	MFS_sugar_transport-like	SLC22A14 SLC2A1	9.18e-03	36	75	2	IPR005828
Domain	Sugar_tr	SLC22A14 SLC2A1	9.18e-03	36	75	2	PF00083
Domain	TGFB	INHA GDF1	9.68e-03	37	75	2	SM00204
Domain	TGF-b_C	INHA GDF1	9.68e-03	37	75	2	IPR001839
Domain	TGF_BETA_2	INHA GDF1	9.68e-03	37	75	2	PS51362
Domain	TGF_beta	INHA GDF1	9.68e-03	37	75	2	PF00019
Pathway	REACTOME_GPCR_LIGAND_BINDING	FZD1 FZD6 S1PR5 TAS1R3 C5AR2 GPR37L1 ADGRE5 PLPPR2 PTH1R	4.31e-05	463	52	9	M507
Pathway	REACTOME_ACETYLCHOLINE_INHIBITS_CONTRACTION_OF_OUTER_HAIR_CELLS	KCNN2 CHRNA10	1.33e-04	5	52	2	M41824
Pathway	REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS	FZD1 FZD6 ADGRE5 PTH1R	3.93e-04	94	52	4	M797
Pathway	WP_GPCRS_NONODORANT	FZD1 FZD6 S1PR5 C5AR2 ADGRE5 PTH1R	4.19e-04	266	52	6	MM15843
Pathway	WP_GPCRS_OTHER	FZD1 S1PR5 GPR37L1 ADGRE5	4.26e-04	96	52	4	MM15939
Pathway	REACTOME_HIGHLY_CALCIUM_PERMEABLE_NICOTINIC_ACETYLCHOLINE_RECEPTORS	CHRNA2 CHRNA4	4.73e-04	9	52	2	M27597
Pathway	REACTOME_HIGHLY_CALCIUM_PERMEABLE_NICOTINIC_ACETYLCHOLINE_RECEPTORS	CHRNA2 CHRNA4	4.73e-04	9	52	2	MM15313
Pathway	REACTOME_HIGHLY_CALCIUM_PERMEABLE_POSTSYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS	CHRNA2 CHRNA4	7.19e-04	11	52	2	M883
Pathway	REACTOME_PRESYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS	CHRNA2 CHRNA4	8.60e-04	12	52	2	M48008
Pathway	REACTOME_HIGHLY_CALCIUM_PERMEABLE_POSTSYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS	CHRNA2 CHRNA4	8.60e-04	12	52	2	MM15312
Pathway	REACTOME_GPCR_LIGAND_BINDING	S1PR5 TAS1R3 C5AR2 GPR37L1 ADGRE5 PLPPR2 PTH1R	9.56e-04	430	52	7	MM15160
Pathway	REACTOME_SIGNALING_BY_GPCR	FZD1 FZD6 S1PR5 TAS1R3 C5AR2 GPR37L1 ADGRE5 PLPPR2 PTH1R	9.59e-04	702	52	9	M746
Pathway	REACTOME_SENSORY_PROCESSING_OF_SOUND_BY_OUTER_HAIR_CELLS_OF_THE_COCHLEA	PCDH15 KCNN2 CHRNA10	1.08e-03	55	52	3	M41823
Pathway	REACTOME_LYSOSPHINGOLIPID_AND_LPA_RECEPTORS	S1PR5 PLPPR2	1.18e-03	14	52	2	M27331
Pathway	REACTOME_LYSOSPHINGOLIPID_AND_LPA_RECEPTORS	S1PR5 PLPPR2	1.18e-03	14	52	2	MM15062
Pathway	KEGG_MEDICUS_REFERENCE_WNT_SIGNALING_MODULATION_SOST_LRP4	FZD1 FZD6	1.18e-03	14	52	2	M47834
Pathway	REACTOME_ACETYLCHOLINE_BINDING_AND_DOWNSTREAM_EVENTS	CHRNA2 CHRNA4	1.18e-03	14	52	2	M757
Pathway	REACTOME_ACETYLCHOLINE_BINDING_AND_DOWNSTREAM_EVENTS	CHRNA2 CHRNA4	1.36e-03	15	52	2	MM14704
Pathway	KEGG_OTHER_GLYCAN_DEGRADATION	ENGASE AGA	1.55e-03	16	52	2	M17844
Pathway	KEGG_MEDICUS_REFERENCE_WNT5A_ROR_SIGNALING_PATHWAY	FZD1 FZD6	1.55e-03	16	52	2	M47823
Pubmed	Kv2.1 mediates spatial and functional coupling of L-type calcium channels and ryanodine receptors in mammalian neurons.	KCNB1 KCNB2 RYR2	1.00e-07	5	76	3	31663850
Pubmed	Why do young women smoke? VI. A controlled study of nicotine effects on attention: pharmacogenetic interactions.	CHRNA10 CHRNA2 CHRNA4	3.49e-07	7	76	3	20231857
Pubmed	Why do young women smoke? V. Role of direct and interactive effects of nicotinic cholinergic receptor gene variation on neurocognitive function.	CHRNA10 CHRNA2 CHRNA4	5.57e-07	8	76	3	17559419
Pubmed	Sources of energy for gating by neurotransmitters in acetylcholine receptor channels.	CHRNA10 CHRNA2 CHRNA4	8.34e-07	9	76	3	22647603
Pubmed	Multiple cholinergic nicotinic receptor genes affect nicotine dependence risk in African and European Americans.	CHRNA10 CHRNA2 CHRNA4	2.17e-06	12	76	3	20584212
Pubmed	Kv2.1 Clustering Contributes to Insulin Exocytosis and Rescues Human β-Cell Dysfunction.	KCNB1 KCNB2	4.71e-06	2	76	2	28607108
Pubmed	Absence of major histocompatibility class II expression does not impair hematopoiesis in mice.	CIITA PCDH15	4.71e-06	2	76	2	11532347
Pubmed	Structure and polymorphism of the mouse myelin/oligodendrocyte glycoprotein gene.	OMG MOG	4.71e-06	2	76	2	7829100
Pubmed	Kv2 Ion Channels Determine the Expression and Localization of the Associated AMIGO-1 Cell Adhesion Molecule in Adult Brain Neurons.	KCNB1 KCNB2	4.71e-06	2	76	2	29403353
Pubmed	Remodeling neuronal ER-PM junctions is a conserved nonconducting function of Kv2 plasma membrane ion channels.	KCNB1 KCNB2	4.71e-06	2	76	2	30091655
Pubmed	How mutations in the nAChRs can cause ADNFLE epilepsy.	CHRNA2 CHRNA4	4.71e-06	2	76	2	12121305
Pubmed	Distinct Cell- and Layer-Specific Expression Patterns and Independent Regulation of Kv2 Channel Subtypes in Cortical Pyramidal Neurons.	KCNB1 KCNB2	4.71e-06	2	76	2	26538660
Pubmed	SK2 channels are required for function and long-term survival of efferent synapses on mammalian outer hair cells.	KCNN2 CHRNA10	4.71e-06	2	76	2	18848895
Pubmed	Multiple distinct risk loci for nicotine dependence identified by dense coverage of the complete family of nicotinic receptor subunit (CHRN) genes.	CHRNA10 CHRNA2 CHRNA4	5.50e-06	16	76	3	19259974
Pubmed	No evidence for association between 19 cholinergic genes and bipolar disorder.	CHRNA10 CHRNA2 CHRNA4	9.47e-06	19	76	3	17373692
Pubmed	The role of voltage-gated potassium channels Kv2.1 and Kv2.2 in the regulation of insulin and somatostatin release from pancreatic islets.	KCNB1 KCNB2	1.41e-05	3	76	2	23161216
Pubmed	Kv8.1, a new neuronal potassium channel subunit with specific inhibitory properties towards Shab and Shaw channels.	KCNB1 KCNB2	1.41e-05	3	76	2	8670833
Pubmed	A novel mutation of the nicotinic acetylcholine receptor gene CHRNA4 in sporadic nocturnal frontal lobe epilepsy.	CHRNA2 CHRNA4	1.41e-05	3	76	2	19058950
Pubmed	Alpha4 and beta2 subunits of neuronal nicotinic acetylcholine receptor genes are not associated with methamphetamine-use disorder in the Japanese population.	CHRNA2 CHRNA4	1.41e-05	3	76	2	18991851
Pubmed	CHRNA2 mutations are rare in the NFLE population: evaluation of a large cohort of Italian patients.	CHRNA2 CHRNA4	1.41e-05	3	76	2	18226955
Pubmed	Expression and function of K(V)2-containing channels in human urinary bladder smooth muscle.	KCNB1 KCNB2	1.41e-05	3	76	2	22422395
Pubmed	Identification of VAPA and VAPB as Kv2 Channel-Interacting Proteins Defining Endoplasmic Reticulum-Plasma Membrane Junctions in Mammalian Brain Neurons.	KCNB1 KCNB2	2.82e-05	4	76	2	30012696
Pubmed	Purification and partial structural and functional characterization of mouse myelin/oligodendrocyte glycoprotein.	OMG MOG	2.82e-05	4	76	2	1373175
Pubmed	De novo central nervous system processing of myelin antigen is required for the initiation of experimental autoimmune encephalomyelitis.	CIITA MOG	2.82e-05	4	76	2	11937578
Pubmed	Distinct cellular expression and subcellular localization of Kv2 voltage-gated K+ channel subtypes in dorsal root ganglion neurons conserved between mice and humans.	KCNB1 KCNB2	2.82e-05	4	76	2	38335058
Pubmed	CD200 receptor controls sex-specific TLR7 responses to viral infection.	TLR7 CD200R1L	2.82e-05	4	76	2	22615569
Pubmed	A large-scale candidate gene association study of age at menarche and age at natural menopause.	INHA CHRNA10 GDF1 CHRNA2 CHRNA4 PTH1R	3.18e-05	275	76	6	20734064
Pubmed	Kv2 channel-AMIGO β-subunit assembly modulates both channel function and cell adhesion molecule surface trafficking.	KCNB1 KCNB2	4.69e-05	5	76	2	34137443
Pubmed	Mutation of histidine 105 in the T1 domain of the potassium channel Kv2.1 disrupts heteromerization with Kv6.3 and Kv6.4.	KCNB1 KCNB2	4.69e-05	5	76	2	19074135
Pubmed	C5a receptor (CD88) blockade protects against MPO-ANCA GN.	MPO C5AR2	4.69e-05	5	76	2	24179165
Pubmed	Non-association between polymorphisms of the frizzled receptor genes and bone mineral density in postmenopausal Korean women.	FZD1 FZD6	4.69e-05	5	76	2	19543507
Pubmed	K+ current diversity is produced by an extended gene family conserved in Drosophila and mouse.	KCNB1 KCNB2	4.69e-05	5	76	2	2333511
Pubmed	The Gastric Mucosa from Patients Infected with CagA+ or VacA+ Helicobacter pylori Has a Lower Level of Dual Oxidase-2 Expression than Uninfected or Infected with CagA-/VacA- H. pylori.	MPO DUOX2	4.69e-05	5	76	2	27048452
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	FZD6 UBR2 FAM234B SCAP MEGF8 SLC39A1 TRIM28 L1CAM TMEM131L ADGRE5 TMEM164	5.83e-05	1201	76	11	35696571
Pubmed	Wnt/Rspondin/β-catenin signals control axonal sorting and lineage progression in Schwann cell development.	FZD1 FZD6 L1CAM	6.80e-05	36	76	3	24151333
Pubmed	Plasmacytoid dendritic cells control T-cell response to chronic viral infection.	CIITA TLR7	7.03e-05	6	76	2	22315415
Pubmed	Developmental changes in nicotinic receptor mRNAs and responses to nicotine in the suprachiasmatic nucleus and other brain regions.	CHRNA2 CHRNA4	7.03e-05	6	76	2	10095079
Pubmed	Oligodendrocytes expressing exclusively the DM20 isoform of the proteolipid protein gene: myelination and development.	OMG MOG	7.03e-05	6	76	2	11746780
Pubmed	Impact of Key Nicotinic AChR Subunits on Post-Stroke Pneumococcal Pneumonia.	CHRNA10 CHRNA2	7.03e-05	6	76	2	32481512
Pubmed	Sequence requirements of the FFAT-like motif for specific binding to VAP-A are revealed by NMR.	KCNB1 KCNB2	9.83e-05	7	76	2	34312846
Pubmed	Chromosomal localization of seven neuronal nicotinic acetylcholine receptor subunit genes in humans.	CHRNA2 CHRNA4	9.83e-05	7	76	2	1505988
Pubmed	Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R).	FZD1 FZD6	9.83e-05	7	76	2	15370539
Pubmed	Differential expression of the Wnt putative receptors Frizzled during mouse somitogenesis.	FZD1 FZD6	1.31e-04	8	76	2	10559494
Pubmed	The cytoskeleton-associated protein SCHIP1 is involved in axon guidance, and is required for piriform cortex and anterior commissure development.	L1CAM MOG	1.31e-04	8	76	2	25953347
Pubmed	Temporal and spatial expression profiles of the Fat3 protein, a giant cadherin molecule, during mouse development.	FAT3 L1CAM	1.31e-04	8	76	2	17131403
Pubmed	Genome-scale RNAi screen for host factors required for HIV replication.	MPO ABHD16B FAM178B TMEM131L ADGRE5 PTH1R	1.42e-04	361	76	6	18976975
Pubmed	Genome-wide association identifies genetic variants associated with lentiform nucleus volume in N = 1345 young and elderly subjects.	SLC39A1 DENND4B	1.68e-04	9	76	2	22903471
Pubmed	Comparative structure of human neuronal alpha 2-alpha 7 and beta 2-beta 4 nicotinic acetylcholine receptor subunits and functional expression of the alpha 2, alpha 3, alpha 4, alpha 7, beta 2, and beta 4 subunits.	CHRNA2 CHRNA4	1.68e-04	9	76	2	8906617
Pubmed	Rodent habenulo-interpeduncular pathway expresses a large variety of uncommon nAChR subtypes, but only the alpha3beta4* and alpha3beta3beta4* subtypes mediate acetylcholine release.	CHRNA2 CHRNA4	1.68e-04	9	76	2	19228980
Pubmed	Expression of Frizzled genes in developing and postnatal hair follicles.	FZD1 FZD6	2.10e-04	10	76	2	15245425
Pubmed	Autosomal Dominant Sleep-Related Hypermotor (Hyperkinetic) Epilepsy	CHRNA2 CHRNA4	2.10e-04	10	76	2	20301348
Pubmed	Essential roles of mesenchyme-derived beta-catenin in mouse Müllerian duct morphogenesis.	FZD1 FZD6	2.10e-04	10	76	2	17532316
Pubmed	Resequencing of nicotinic acetylcholine receptor genes and association of common and rare variants with the Fagerström test for nicotine dependence.	CHRNA2 CHRNA4	2.10e-04	10	76	2	20736995
Pubmed	High-throughput engineering of the mouse genome coupled with high-resolution expression analysis.	C5AR2 TLR7	2.10e-04	10	76	2	12730667
Pubmed	Large-scale analysis of ion channel gene expression in the mouse heart during perinatal development.	KCNB1 KCNN2 KCNB2 RYR2	2.51e-04	139	76	4	16985003
Pubmed	Frizzled-9 impairs acetylcholine receptor clustering in skeletal muscle cells.	FZD1 FZD6	2.56e-04	11	76	2	24860427
Pubmed	Differential expression of nicotinic acetylcholine receptor subunits in fetal and neonatal mouse thymus.	CHRNA2 CHRNA4	2.56e-04	11	76	2	12225896
Pubmed	Molecular determinants of WNT9b responsiveness in nephron progenitor cells.	FZD1 FZD6	2.56e-04	11	76	2	30978219
Pubmed	Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study.	KCNB2 RYR2	2.56e-04	11	76	2	17903301
Pubmed	Distinct but redundant expression of the Frizzled Wnt receptor genes at signaling centers of the developing mouse brain.	FZD1 FZD6	2.56e-04	11	76	2	17582687
Pubmed	Partial interchangeability of Fz3 and Fz6 in tissue polarity signaling for epithelial orientation and axon growth and guidance.	FZD1 FZD6	2.56e-04	11	76	2	25294940
Pubmed	Expression of Frizzled5, Frizzled7, and Frizzled10 during early mouse development and interactions with canonical Wnt signaling.	FZD1 FZD6	2.56e-04	11	76	2	17576136
Pubmed	FFAT motif phosphorylation controls formation and lipid transfer function of inter-organelle contacts.	KCNB1 KCNB2	2.56e-04	11	76	2	33124732
Pubmed	L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms.	SLC22A14 SLC2A1 PTH1R RYR2	2.79e-04	143	76	4	20424473
Pubmed	Genetic interaction between Wnt/beta-catenin and BMP receptor signaling during formation of the AER and the dorsal-ventral axis in the limb.	FZD1 FZD6	3.62e-04	13	76	2	12923052
Pubmed	Sour Sensing from the Tongue to the Brain.	TAS1R3 SLC38A11	4.22e-04	14	76	2	31543264
Pubmed	Thirteen genes (Cebpb, E2f1, Tcf4, Cyp24, Pck1, Acra4, Edn3, Kcnb1, Mc3r, Ntsr, Cd40, Plcg1 and Rcad) that probably lie in the distal imprinting region of mouse chromosome 2 are not monoallelically expressed.	KCNB1 CHRNA4	4.22e-04	14	76	2	7781998
Pubmed	Design and expression of human alpha7 nicotinic acetylcholine receptor extracellular domain mutants with enhanced solubility and ligand-binding properties.	CHRNA2 CHRNA4	4.22e-04	14	76	2	19059502
Pubmed	Analysis of nicotinic acetylcholine receptor subunits in the cochlea of the mouse.	CHRNA2 CHRNA4	4.86e-04	15	76	2	8838678
Pubmed	Evolutionary origin of amino acid transporter families SLC32, SLC36 and SLC38 and physiological, pathological and therapeutic aspects.	SLC36A1 SLC38A11	4.86e-04	15	76	2	23506890
Pubmed	Alteration of Neuronal Excitability and Short-Term Synaptic Plasticity in the Prefrontal Cortex of a Mouse Model of Mental Illness.	KCNB1 L1CAM	5.54e-04	16	76	2	28283561
Pubmed	ALK4 coordinates extracellular and intrinsic signals to regulate development of cortical somatostatin interneurons.	GDF1 CHRNA2	5.54e-04	16	76	2	31676717
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	FAM234B SCAP AOPEP AGA TMEM131L GEMIN5 ADGRE5 PATJ SLC2A1	5.89e-04	1084	76	9	11544199
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	FZD1 ENGASE SCAP MEGF8 TRIM28 IL17RE L1CAM GEMIN5 SLC2A1	6.75e-04	1105	76	9	35748872
Pubmed	Chromosomal localization of the mouse genes coding for alpha 2, alpha 3, alpha 4 and beta 2 subunits of neuronal nicotinic acetylcholine receptor.	CHRNA2 CHRNA4	7.05e-04	18	76	2	2338144
Pubmed	Regulation of angiogenesis by a non-canonical Wnt-Flt1 pathway in myeloid cells.	FZD1 FZD6	7.87e-04	19	76	2	21623369
Pubmed	Follow-up examination of linkage and association to chromosome 1q43 in multiple sclerosis.	WDR64 RYR2	8.73e-04	20	76	2	19626040
Pubmed	Wnt/beta-catenin signaling is required for CNS, but not non-CNS, angiogenesis.	FZD6 SLC2A1	9.63e-04	21	76	2	19129494
Pubmed	Analysis of FGF20-regulated genes in organ of Corti progenitors by translating ribosome affinity purification.	FAT3 SPRY4	9.63e-04	21	76	2	32492250
Pubmed	Glucocorticoid receptor is required for foetal heart maturation.	SLC2A1 RYR2	1.06e-03	22	76	2	23595884
Pubmed	Expression of the Wnt inhibitor Dickkopf-1 is required for the induction of neural markers in mouse embryonic stem cells differentiating in response to retinoic acid.	FZD1 FZD6	1.06e-03	22	76	2	17064353
Pubmed	ATP-citrate lyase deficiency in the mouse.	FZD1 SCAP	1.16e-03	23	76	2	14662765
Pubmed	Quantitative trait loci for body size components in mice.	SCAP CIITA PTH1R	1.31e-03	98	76	3	16783635
Pubmed	A role for Wnt/beta-catenin signaling in lens epithelial differentiation.	FZD1 FZD6	1.37e-03	25	76	2	12812787
Pubmed	Symmetric neural progenitor divisions require chromatin-mediated homologous recombination DNA repair by Ino80.	TRIM28 L1CAM	1.37e-03	25	76	2	32737294
Pubmed	Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins.	GPR37L1 TLR7 CD200R1L	1.43e-03	101	76	3	23382219
Pubmed	TNF deficiency causes alterations in the spatial organization of neurogenic zones and alters the number of microglia and neurons in the cerebral cortex.	FZD6 SLC2A1	1.60e-03	27	76	2	31505254
Pubmed	Combining global genome and transcriptome approaches to identify the candidate genes of small-effect quantitative trait loci in collagen-induced arthritis.	FAM234B RASAL3	1.60e-03	27	76	2	17244351
Pubmed	Differential effects of Tat proteins derived from HIV-1 subtypes B and recombinant CRF02_AG on human brain microvascular endothelial cells: implications for blood-brain barrier dysfunction.	KCNB1 PCDH15 KYNU	1.60e-03	105	76	3	24667918
Pubmed	A trimeric Rab7 GEF controls NPC1-dependent lysosomal cholesterol export.	SLC39A1 TRIM28 L1CAM GEMIN5 SLC2A1	1.70e-03	392	76	5	33144569
Pubmed	Frizzled 1 and frizzled 2 genes function in palate, ventricular septum and neural tube closure: general implications for tissue fusion processes.	FZD1 FZD6	1.72e-03	28	76	2	20940229
Pubmed	3D representation of Wnt and Frizzled gene expression patterns in the mouse embryo at embryonic day 11.5 (Ts19).	FZD1 FZD6	1.84e-03	29	76	2	18364260
Pubmed	Canonical Wnt signaling regulates organ-specific assembly and differentiation of CNS vasculature.	FZD6 SLC2A1	1.84e-03	29	76	2	19023080
Pubmed	Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.	UBR2 TRIM67 KCNB1 AOPEP KCNN2 PATJ RYR2	2.02e-03	814	76	7	23251661
Pubmed	Human neutrophils secrete bioactive paucimannosidic proteins from azurophilic granules into pathogen-infected sputum.	MPO AGA	2.10e-03	31	76	2	25645918
Pubmed	TBX1 is required for normal stria vascularis and semicircular canal development.	SLC2A1 RNF138	2.10e-03	31	76	2	31550482
Pubmed	Voltage-gated potassium channel genes are clustered in paralogous regions of the mouse genome.	KCNB1 KCNB2	2.10e-03	31	76	2	8034307
Pubmed	D-2-hydroxyglutarate produced by mutant IDH1 perturbs collagen maturation and basement membrane function.	CREB3L1 SLC2A1	2.10e-03	31	76	2	22925884
Pubmed	Amino acid transport across mammalian intestinal and renal epithelia.	SLC36A1 SLC7A7	2.10e-03	31	76	2	18195088
Pubmed	PlexinA1 signaling directs the segregation of proprioceptive sensory axons in the developing spinal cord.	FZD1 FZD6 L1CAM	2.18e-03	117	76	3	17145500
GeneFamily	Cholinergic receptors nicotinic subunits	CHRNA10 CHRNA2 CHRNA4	1.02e-05	16	49	3	173
GeneFamily	G protein-coupled receptors, Class F frizzled	FZD1 FZD6	3.90e-04	11	49	2	286
GeneFamily	Solute carriers	SLC36A1 SLC39A1 SLC22A14 SLC38A11 SLC7A7 SLC2A1	6.62e-04	395	49	6	752
GeneFamily	Cadherin related	FAT3 PCDH15	9.53e-04	17	49	2	24
GeneFamily	Potassium voltage-gated channels	KCNB1 KCNB2	5.26e-03	40	49	2	274
GeneFamily	WD repeat domain containing	WDR64 SCAP WDR97 GEMIN5	5.48e-03	262	49	4	362
GeneFamily	Ring finger proteins	RNF144B TRIM67 TRIM28 RNF138	6.49e-03	275	49	4	58
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Lect1_Oxtr\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	FZD1 RNF144B CBLN2 PCDH15 CHRNA4	5.69e-06	149	76	5	10ffd0051fb027bbebc662ca602c80d89bbf99c6
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22-Myeloid-Monocytic-Nonclassical_Monocyte-Mono_c5-CD16\|Severe-critical_progression_d12-22 / Compartment, severity and other cell annotations on 10x 3' data (130k)	FZD1 RNF144B ENGASE IL17RE TLR7	1.11e-05	171	76	5	87d652afbb375f8ee50e5faecf6085630cd2163c
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Monocytic-Monocyte-derived_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	S1PR5 RASAL3 CIITA TLR7 KYNU	1.14e-05	172	76	5	f6b4754a7e4b3e38030316a0ae00d932bfa87e41
ToppCell	facs-Brain_Myeloid-Hippocampus-3m-Myeloid-macrophage\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	S1PR5 CIITA TAS1R3 L1CAM KYNU	1.18e-05	173	76	5	c63a615998d13b1725b5767f4ad2ec7e2b61db68
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD\|renal_cortex_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group	FAT3 PCDH15 PATJ PTH1R RYR2	1.46e-05	181	76	5	c80ffa2ded5975a88e9a1a7d333196f95237bf0a
ToppCell	droplet-Limb_Muscle-MUSCLE-1m-Macroglial-unknown\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FZD1 L1CAM GPR37L1 KCNN2 MOG	1.50e-05	182	76	5	82ca6d5ed48b4c487ce00b9309255abb8f20b61d
ToppCell	3'_v3-lymph-node_spleen-Myeloid_Monocytic-Nonclassical_monocytes\|lymph-node_spleen / Manually curated celltypes from each tissue	FZD1 RNF144B C5AR2 SLC7A7 KYNU	1.67e-05	186	76	5	d7da5edb2ee36f96cdd7e27eb9afcc1cbfd52bb6
ToppCell	droplet-Limb_Muscle-MUSCLE-30m-Macroglial-Schwann_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FZD1 FAM178B L1CAM GPR37L1 MOG	1.85e-05	190	76	5	ff3dec5b45c6ea9b5319fb51a0198c6773b7be26
ToppCell	facs-Brain_Non-Myeloid-Cortex-3m-Macroglial-oligodendrocyte_precursor_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TRIM67 SPRY4 PCDH15 GPR37L1 CHRNA4	1.85e-05	190	76	5	9b825b2586c7b173ff27fcf2abc5860faf50984a
ToppCell	facs-Brain_Non-Myeloid-Cortex-3m-Macroglial-Oligodendrocyte_progenitor_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TRIM67 SPRY4 PCDH15 GPR37L1 CHRNA4	1.85e-05	190	76	5	d146af1926474328a7c822bc140c4dda66e1bbfb
ToppCell	droplet-Limb_Muscle-MUSCLE-30m-Macroglial\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FZD1 FAM178B L1CAM GPR37L1 MOG	1.85e-05	190	76	5	4971857eac9af17d66d673ed2ab7072639f60a10
ToppCell	3'_v3-bone_marrow-Myeloid_Monocytic-Nonclassical_monocytes\|bone_marrow / Manually curated celltypes from each tissue	FZD1 RNF144B C5AR2 SLC7A7 KYNU	1.99e-05	193	76	5	dc309c249d569e93dc2b154e002212a6eee44497
ToppCell	Fetal_29-31_weeks-Immune-interstitial_macrophage_(C1Q_positive)\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	RNF144B SLC36A1 CIITA C5AR2 KYNU	2.09e-05	195	76	5	312d9625655b38f1a7c2bf8f8bb7b667ebdf9617
ToppCell	(001)_CD16+_Monocyte\|World / immune cells in Peripheral Blood (logTPM normalization)	FZD1 RNF144B C5AR2 SLC7A7 KYNU	2.14e-05	196	76	5	33843d550cbca03c044d593b1f6972e4d3871f7f
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-3m-Macroglial\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	S1PR5 FAM234B PCBP4 OMG MOG	2.36e-05	200	76	5	56f1f007ba8c9188a4b10e52744f1e50dc0f155a
ToppCell	Globus_pallidus-Macroglia-OLIGODENDROCYTE-O2\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	S1PR5 FAM178B FTMT MOG	5.68e-05	122	76	4	d4152c45dfbb979ddf8380b4896db753a79cad9e
ToppCell	Globus_pallidus-Macroglia-OLIGODENDROCYTE-O2-Trf\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	S1PR5 FAM178B FTMT MOG	5.68e-05	122	76	4	40f983623c990203df4ba997e296231489d51012
ToppCell	Posterior_cortex-Macroglia-OLIGODENDROCYTE\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	S1PR5 FAM178B FTMT MOG	6.05e-05	124	76	4	9f169fa17be1842a6bd83778ff30465a740edd5f
ToppCell	Thalamus-Macroglia-OLIGODENDROCYTE\|Thalamus / BrainAtlas - Mouse McCarroll V32	S1PR5 FAM178B FTMT MOG	7.05e-05	129	76	4	b3cb0c10659d1216b8f7de3aa1f9aac101cb65dd
ToppCell	Globus_pallidus-Macroglia-OLIGODENDROCYTE\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	S1PR5 FAM178B FTMT MOG	7.05e-05	129	76	4	98a5f24de72d2ae6a57787226b2e523ddd13b2c5
ToppCell	PBMC-Mild-Lymphocyte-B-B_cell-B_naive-B_naive-1\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	CIITA TMEM131L SLC38A11 KCNB2	7.49e-05	131	76	4	a3a086ce6e69707ca6a042f3b15c130f81909acb
ToppCell	metastatic_Brain-T/NK_cells-CD8_low_T\|T/NK_cells / Location, Cell class and cell subclass	FZD1 KCNB1 INHA TLR7	9.16e-05	138	76	4	b2ab273f3e62f169b3b9cb82342e6617af99f582
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Lymphocytic_B\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	WDR64 RASAL3 TAS1R3 MEI1	1.05e-04	143	76	4	360a2ea8b64e3b9084f4c4cb8beb0d44106b9edb
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Lymphocytic_B-Plasma_Cell-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	WDR64 RASAL3 TAS1R3 MEI1	1.05e-04	143	76	4	605532fc0f32979b306cbb58f8796df7d6b24828
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Lymphocytic_B-Plasma_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	WDR64 RASAL3 TAS1R3 MEI1	1.05e-04	143	76	4	5cc59deb5a8af8095c1581e585eaeeecdd938621
ToppCell	TCGA-Brain-Primary_Tumor-Low_Grade_Glioma-Oligodendroglioma-4\|TCGA-Brain / Sample_Type by Project: Shred V9	CBLN2 KCNB2 CHRNA2 RYR2	1.14e-04	146	76	4	632f52780607c638b5d3dd3fb9251c719f162a35
ToppCell	droplet-Kidney-nan-24m-Lymphocytic-CD45____macrophage\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MPO S1PR5 C5AR2 TLR7	1.26e-04	150	76	4	34774b015adecc2be56a471fda8994e89a6ad93e
ToppCell	10x_3'_v2v3-Non-neoplastic-Glial-Neuronal-OPC-OPC-E\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	KCNB1 SPRY4 PCDH15 GPR37L1	1.43e-04	155	76	4	77fdae85d36efb776db977eb424b32487ef222e4
ToppCell	facs-Lung-18m-Hematologic-myeloid-non-classical_monocyte-nonclassical_monocyte_l4\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	S1PR5 DENND4B L1CAM TLR7	1.54e-04	158	76	4	121d63b8e2e37107467b170e5b2c798a7dbf6325
ToppCell	Severe-B_naive-1\|Severe / disease group and sub_cluster of B and Plasma cells(res = 0.5)	CIITA TMEM131L PATJ CHRNA2	1.58e-04	159	76	4	2881b054bbeb479221ee3c38bbd9b0815b123579
ToppCell	facs-Lung-Endomucin-3m-Lymphocytic-CD4+_T\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RASAL3 GPR37L1 TMEM131L MOG	1.62e-04	160	76	4	5c68d6a76c59e3a7e668ae5471396478a55756ac
ToppCell	facs-Lung-18m-Hematologic-myeloid-non-classical_monocyte\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	S1PR5 DENND4B L1CAM TLR7	1.62e-04	160	76	4	bc4a93dc5f37829799c37877e751ff3bc122e4ab
ToppCell	facs-Lung-Endomucin-3m-Lymphocytic-CD4-positive,_alpha-beta_T_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RASAL3 GPR37L1 TMEM131L MOG	1.62e-04	160	76	4	0fee84844733d36805e1df90ca09478169746708
ToppCell	COVID-19-kidney-Technical/muscle_(Imm)\|kidney / Disease (COVID-19 only), tissue and cell type	WDR64 KCNB1 PCDH15 RYR2	1.74e-04	163	76	4	19c28ce16a588a7f4a035c32726f6ccd67702b5b
ToppCell	facs-GAT-Fat-3m-Lymphocytic-CD8-positive,_alpha-beta_T_cell\|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RASAL3 KCNN2 PATJ RNF138	1.86e-04	166	76	4	3695407e4638f3c18fbff63daba52baa9256c429
ToppCell	facs-Diaphragm-Limb_Muscle-24m\|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TAS1R3 FAT3 PCDH15 RYR2	2.00e-04	169	76	4	12bdc709bc000d7f9061ecd9fbd57233eaacb7e2
ToppCell	LPS-antiTNF-Myeloid-Dendritic_cells\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CIITA GLIPR1L2 TLR7 KYNU	2.04e-04	170	76	4	3cbeea6bfa500928c413b1c6129f6dedc769cd1e
ToppCell	10x_3'_v2v3-Non-neoplastic-Vascular-Mural_cell-Pericyte-B\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	CBLN2 SLC38A11 PTH1R RYR2	2.09e-04	171	76	4	a4a2c5dc995589fbe3d4ca6ee1df888807e4ae34
ToppCell	Pericytes-Donor_02\|World / lung cells shred on cell class, cell subclass, sample id	KCNB1 IGFL2 SLC38A11 RYR2	2.09e-04	171	76	4	bbc8d9fc83d37c9250345b1e76776610799de9ae
ToppCell	Hippocampus-Macroglia-OLIGODENDROCYTE-O1-Trf\|Hippocampus / BrainAtlas - Mouse McCarroll V32	GLIPR1L2 FTMT MOG	2.15e-04	68	76	3	31f9f6b4473970473f89b67643bb55dc332732d8
ToppCell	Hippocampus-Macroglia-OLIGODENDROCYTE-O1-Trf-Oligodendrocyte.Trf.Il33_(Il33)\|Hippocampus / BrainAtlas - Mouse McCarroll V32	GLIPR1L2 FTMT MOG	2.15e-04	68	76	3	91a500a68245a8a484a537aad2cc8b62ff4579f0
ToppCell	Hippocampus-Macroglia-OLIGODENDROCYTE-O1-Trf-Oligodendrocyte.Trf.Il33_(Il33)-\|Hippocampus / BrainAtlas - Mouse McCarroll V32	GLIPR1L2 FTMT MOG	2.15e-04	68	76	3	a89cc6fb62f50ea4124b1a6b0b30cd7ceb52e408
ToppCell	Hippocampus-Macroglia-OLIGODENDROCYTE-O1\|Hippocampus / BrainAtlas - Mouse McCarroll V32	GLIPR1L2 FTMT MOG	2.15e-04	68	76	3	3d148bb49246c3fac9a1e864ecc5e15b29863c52
ToppCell	facs-Brain_Myeloid-Cerebellum-3m-Myeloid-nan\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RNF144B SLC39A1 FAT3 TLR7	2.18e-04	173	76	4	869da6a65d1b9b7529c666ec44e3c8ddec2ea408
ToppCell	5'-Adult-Distal_Rectal-Hematopoietic\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FZD1 CIITA C5AR2 CHRNA10	2.18e-04	173	76	4	b335ca2a247156eba821943b2b9fc9922230b409
ToppCell	facs-Brain_Myeloid-Cerebellum-3m-Myeloid\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RNF144B SLC39A1 FAT3 TLR7	2.18e-04	173	76	4	0672bd8a4a9d18af343d01f09253fb3388896c10
ToppCell	facs-Brain_Myeloid-Cerebellum-3m\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RNF144B SLC39A1 FAT3 TLR7	2.18e-04	173	76	4	870e091ec30be01a900e1cb8b9ef1880e3b7b50d
ToppCell	5'-GW_trimst-2-LymphNode-Neuronal-Glial_immature\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	AOPEP L1CAM GPR37L1 PCBP4	2.23e-04	174	76	4	c9d4e375dedd2b099a9ed70ec38ff35bbb0ce48a
ToppCell	5'-GW_trimst-2-LymphNode-Neuronal-Glial_immature-Glia_1_(DHH+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	AOPEP L1CAM GPR37L1 PCBP4	2.23e-04	174	76	4	1463c98f8f519dd030587abbdbeb1b4e1bca5dd1
ToppCell	5'-GW_trimst-2-LymphNode-Neuronal\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	AOPEP L1CAM GPR37L1 PCBP4	2.23e-04	174	76	4	d421c0069d24cb560a3a429929e3cd1eceaeabcf
ToppCell	5'-Adult-LargeIntestine-Hematopoietic-Myeloid-Lymphoid_DC\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RNF144B CIITA KCNN2 KYNU	2.23e-04	174	76	4	16204ff504b7b382b4d90ca35003ad5336020e07
ToppCell	facs-Mammary_Gland-Mammary_Gland-3m-Endothelial\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KCNB1 L1CAM GPR37L1 TLR7	2.28e-04	175	76	4	c36b4526970db9ccfbe2c70b00961fab9f13b133
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Immune-Myeloid-Monocytic-Non-classical_Monocyte\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	RASAL3 C5AR2 ADGRE5 KYNU	2.28e-04	175	76	4	e991ffa4d1d278a011592b9915cd35fe76db20cc
ToppCell	facs-Brain_Non-Myeloid-Cortex-24m-Macroglial-oligodendrocyte_precursor_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPRY4 PCDH15 GPR37L1 CHRNA4	2.28e-04	175	76	4	d67c77eee979ad029e7545f383326f0ff77c6e5f
ToppCell	5'-Adult-LargeIntestine-Epithelial-neuro-epithelial-EC_cells_(TAC1+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CBLN2 PCDH15 SLC38A11 KCNB2	2.28e-04	175	76	4	182e45f5c02214d6b9f317ff5dc43af8b42de978
ToppCell	facs-Mammary_Gland-Mammary_Gland-3m-Endothelial-endothelial_cell\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KCNB1 L1CAM GPR37L1 TLR7	2.28e-04	175	76	4	c1e082538f31b5c98ac63f71dcca4a1211a14708
ToppCell	facs-Brain_Myeloid-Cerebellum-3m-Myeloid-microglial_cell\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RNF144B SLC39A1 FAT3 TLR7	2.28e-04	175	76	4	1ea6cf9da26601646f57fa14d558a5e9e1f0b345
ToppCell	facs-Brain_Non-Myeloid-Cortex-24m-Macroglial-Oligodendrocyte_progenitor_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPRY4 PCDH15 GPR37L1 CHRNA4	2.28e-04	175	76	4	1d1cdbf3221b03e24eae38afd57cbd6736b37a53
ToppCell	facs-Mammary_Gland-Mammary_Gland-3m-Endothelial-nan\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KCNB1 L1CAM GPR37L1 TLR7	2.28e-04	175	76	4	2f9b5bdf8a62e8e99d1c4f677a8e5525bfd3b4ce
ToppCell	facs-Brain_Non-Myeloid-Striatum_-18m-Myeloid-microglial_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RASAL3 C5AR2 TLR7 SLC7A7	2.38e-04	177	76	4	201b0a8e6402a18aff0bb7c14f2bdd34fdf0db32
ToppCell	facs-Brain_Non-Myeloid-Striatum_-18m-Myeloid-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RASAL3 C5AR2 TLR7 SLC7A7	2.38e-04	177	76	4	2a63288d09efd217b277aeecf957811a095f56e7
ToppCell	facs-Brain_Non-Myeloid-Striatum_-18m-Myeloid\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RASAL3 C5AR2 TLR7 SLC7A7	2.38e-04	177	76	4	56fe389ffab73e3bc64f837b152d5907e3517a91
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_3\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FAT3 CBLN2 KCNN2 SLC38A11	2.43e-04	178	76	4	ccea3c8908d72f5fecd151a133048c8e9758304c
ToppCell	Control-Myeloid-Monocytes,_Macrophages\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	C5AR2 GLIPR1L2 SLC7A7 KYNU	2.49e-04	179	76	4	a79a244bf8ecc333d034b2eb2de554d3310ca6de
ToppCell	Control-Myeloid-Monocytes,_Macrophages-Monocytes-Macrophages\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	C5AR2 GLIPR1L2 SLC7A7 KYNU	2.49e-04	179	76	4	c4ff8b191ed0f6dc2dd784869f6f2c62e170a7db
ToppCell	3'-Adult-LargeIntestine-Epithelial-neuro-epithelial-EC_cells_(TAC1+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FAM234B CBLN2 SLC38A11 KCNB2	2.49e-04	179	76	4	878b15ea62e3405682a538f79f58d74b9cd3f398
ToppCell	Control-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	FAT3 PCDH15 CREB3L1 RYR2	2.54e-04	180	76	4	08ae0f5d95c45feba68ad99788f7af7ff4c979af
ToppCell	5'-Adult-Appendix-Hematopoietic-Myeloid-LYVE1+_Macrophage\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RNF144B CIITA C5AR2 KYNU	2.54e-04	180	76	4	66c7b02d85e32ba3e7530d0c4aff17e7525ccdd8
ToppCell	5'-Adult-Appendix-Neuronal-Glial_mature\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CBLN2 L1CAM GPR37L1 MOG	2.59e-04	181	76	4	3aa81ac64d0cc9a74fbfa71e2176740548e7cd06
ToppCell	5'-Adult-Appendix-Neuronal-Glial_mature-Adult_Glia\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CBLN2 L1CAM GPR37L1 MOG	2.59e-04	181	76	4	997ba1be2824b00d684f2163d0114656ed11fa53
ToppCell	facs-Brain_Non-Myeloid-Hippocampus_-18m-Macroglial\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPRY4 PCDH15 GPR37L1 OMG	2.59e-04	181	76	4	1037051eb82313c13346617b33f3c4c648181c4d
ToppCell	Children_(3_yrs)-Mesenchymal-matrix_fibroblast_1_cell-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	FAT3 PCDH15 PTH1R RYR2	2.59e-04	181	76	4	9ede19228ba5c0668a9c06c915510b95585216ef
ToppCell	5'-Adult-Appendix-Neuronal\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CBLN2 L1CAM GPR37L1 MOG	2.59e-04	181	76	4	e6b7e8dd5c13cc10ba22f2f5a8c669486f934bdc
ToppCell	Control-Myeloid\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	C5AR2 GLIPR1L2 SLC7A7 KYNU	2.59e-04	181	76	4	25170e5285996cc80337d5f86a0255569861ae77
ToppCell	droplet-Limb_Muscle-MUSCLE-1m-Macroglial-Schwann_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FZD1 L1CAM GPR37L1 MOG	2.65e-04	182	76	4	d568a8aec7e27ce632e248baea2ccd0e8dd255ac
ToppCell	facs-Brain_Non-Myeloid-Cerebellum_-18m-Epithelial-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FZD1 GPR37L1 KCNN2 CREB3L1	2.65e-04	182	76	4	904804813849b7f7f716ba1554d33b07bc0a701e
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5-6_PVALB_STON2\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	RNF144B ENGASE PCDH15 TMEM131L	2.65e-04	182	76	4	08aff7112c9dac0ef5540300516a604782b21169
ToppCell	droplet-Limb_Muscle-MUSCLE-1m-Macroglial\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FZD1 L1CAM GPR37L1 MOG	2.65e-04	182	76	4	e89cc30db8e5c77a8bbddd1d5a4b5af09f1ccd67
ToppCell	facs-Brain_Non-Myeloid-Cerebellum_-18m-Epithelial\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FZD1 GPR37L1 KCNN2 CREB3L1	2.65e-04	182	76	4	5d8b7fe18286e27f0f50c5d2d9be56850e2cb8f4
ToppCell	COVID-19-kidney-Distal_Epi_Doublet_(PCT)\|COVID-19 / Disease (COVID-19 only), tissue and cell type	SLC38A11 PATJ SLC2A1 PTH1R	2.65e-04	182	76	4	9d67717a6e13bcb54c1297a3e4e3abf4e51628a3
ToppCell	wk_15-18-Epithelial-PNS-Early_Schwann\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	WDR64 L1CAM PCBP4 MOG	2.70e-04	183	76	4	7e8366ec8117d36cec67f77dcb0e9a6032d87fcb
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PCDH15 SLC7A7 KYNU PTH1R	2.70e-04	183	76	4	facd6dbe0851b537d70a899ac7485714ab27d071
ToppCell	droplet-Limb_Muscle-nan-3m-Macroglial-Schwann_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FZD1 L1CAM GPR37L1 MOG	2.70e-04	183	76	4	2cf36ad89584eb9f8b04de52a1b511b7f3527884
ToppCell	facs-Brain_Non-Myeloid-Hippocampus_-18m-Macroglial-oligodendrocyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	S1PR5 PCBP4 OMG MOG	2.70e-04	183	76	4	eb1f1dd12d1e4f1a7029b5396baada23f7c971ff
ToppCell	facs-Brain_Non-Myeloid-Cerebellum_-18m-Epithelial-Bergmann_glial_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FZD1 GPR37L1 KCNN2 CREB3L1	2.70e-04	183	76	4	99bb4ceb92f6467f2359a42ab2cff6df18825a30
ToppCell	droplet-Limb_Muscle-nan-3m-Macroglial\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FZD1 L1CAM GPR37L1 MOG	2.70e-04	183	76	4	98fee6838acfaee5e2e449ba088764ec06b8bc57
ToppCell	PBMC-Control-Myeloid-Neutrophil-immature_Neutrophil\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	MPO C5AR2 TMEM131L GEMIN5	2.76e-04	184	76	4	a8c6028d745aaa6ee7842259238694cb50ce0526
ToppCell	PBMC-Control-Myeloid-Neutrophil-immature_Neutrophil-Neu_4\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	MPO C5AR2 TMEM131L GEMIN5	2.76e-04	184	76	4	081d045f3bc98a36f342de7d50f39c9a888dd7eb
ToppCell	Control-Myeloid_G-immature_Neutrophil\|Control / Disease group, lineage and cell class	MPO C5AR2 TMEM131L GEMIN5	2.76e-04	184	76	4	45f873236f7e90fb78c8e291d3b5b92d121acec9
ToppCell	droplet-Heart-4Chambers-18m-Neuronal-cardiac_neuron\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IL17RE FAT3 GPR37L1 PATJ	2.76e-04	184	76	4	6388c47b7f1d8203e3069eba0e74107256dcae51
ToppCell	PBMC-Control-Myeloid-Neutrophil-immature_Neutrophil\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	MPO C5AR2 TMEM131L GEMIN5	2.76e-04	184	76	4	84c20730cd92b9aaa50077d7b625e37e7f9e91d2
ToppCell	Control-Myeloid-DC1\|Myeloid / Condition, Lineage and Cell class	FZD6 PATJ PCBP4 SLC2A1	2.76e-04	184	76	4	b5c1f57f0356969cfb0e1dac764684fc5583bc04
ToppCell	facs-Brain_Non-Myeloid-Cortex_-18m-Macroglial-Oligodendrocyte_progenitor_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPRY4 PCDH15 GPR37L1 CHRNA4	2.76e-04	184	76	4	278a7ed764c326450cb70e69ed2175980eaf5fe0
ToppCell	PBMC-Control-Myeloid-Neutrophil-immature_Neutrophil-Neu_4\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	MPO C5AR2 TMEM131L GEMIN5	2.76e-04	184	76	4	d31d4116d1d196633784863781fa45673607a421
ToppCell	droplet-Heart-4Chambers-18m-Neuronal\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IL17RE FAT3 GPR37L1 PATJ	2.76e-04	184	76	4	d83ae1dc64aa1b27d3b524c137567418cc0ff8c6
ToppCell	facs-Brain_Non-Myeloid-Cortex_-18m-Macroglial-oligodendrocyte_precursor_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPRY4 PCDH15 GPR37L1 CHRNA4	2.76e-04	184	76	4	8d86e125257ff1d3af8d90577a8b3f0321eca21c
ToppCell	droplet-Limb_Muscle-nan-18m-Macroglial-unknown\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	L1CAM GPR37L1 KCNN2 MOG	2.76e-04	184	76	4	a7399a72f065d68800e3e0b2031d9894e0cc0ba4
ToppCell	CV-Moderate-7\|Moderate / Virus stimulation, Condition and Cluster	UBR2 CIITA DENND4B TMEM131L	2.82e-04	185	76	4	a6c9203ce6c2892a4a369c9bcfb85720f01cbb3f
ToppCell	facs-Bladder-nan-18m\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC38A11 SLC2A1 MOG RYR2	2.82e-04	185	76	4	3e00879466e626aa8604efecfc4678d64f54dbfc
ToppCell	facs-Bladder-nan-18m-Epithelial\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC38A11 SLC2A1 MOG RYR2	2.82e-04	185	76	4	3dc5812c961ff209f197ff4cbfb90009c0537550
Computational	Ion channels.	KCNB2 CHRNA2 CHRNA4 RYR2	6.60e-05	70	34	4	MODULE_316
Drug	NSC100058	KCNB1 TRIM28 CHRNA10 CHRNA2 CREB3L1 CHRNA4	1.49e-07	74	74	6	CID000003449
Drug	edrophonium	ADGRE5 CHRNA10 OMG CHRNA2 CHRNA4	4.86e-07	48	74	5	CID000003202
Drug	Nicotine	CHRNA10 CHRNA2 CHRNA4	6.55e-07	6	74	3	DB00184
Drug	anabaseine	MPO CHRNA10 CHRNA2 CHRNA4	1.04e-06	24	74	4	CID000018985
Drug	Galantamine	CHRNA10 CHRNA2 CHRNA4	1.82e-06	8	74	3	DB00674
Drug	methylenedioxydimethylamphetamine	FTMT CHRNA10 CHRNA2 CHRNA4	2.64e-06	30	74	4	CID000551630
Drug	M3/M4	CHRNA10 CHRNA2 CHRNA4 RYR2	3.45e-06	32	74	4	CID000486507
Drug	Dns-C6-Cho	CHRNA10 CHRNA2 CHRNA4	5.34e-06	11	74	3	CID000124728
Drug	AC1L9NC9	CHRNA10 CHRNA2 CHRNA4	5.34e-06	11	74	3	CID000449642
Drug	dihydronereistoxin	CHRNA10 CHRNA2 CHRNA4	5.34e-06	11	74	3	CID000121232
Drug	bipinnatin-B	CHRNA10 CHRNA2 CHRNA4	5.34e-06	11	74	3	CID000127363
Drug	LJP 1082	CHRNA10 CHRNA2 CHRNA4	5.34e-06	11	74	3	CID003037609
Drug	1,2-dichlorohexafluorocyclobutane	CHRNA10 CHRNA2 CHRNA4 RYR2	6.26e-06	37	74	4	CID000009643
Drug	O585	CHRNA10 CHRNA2 CHRNA4 PTH1R	6.26e-06	37	74	4	CID000107646
Drug	AC1L9P8C	CHRNA10 CHRNA2 CHRNA4	7.10e-06	12	74	3	CID000450864
Drug	SureCN373116	CHRNA10 CHRNA2 CHRNA4	7.10e-06	12	74	3	CID010085732
Drug	nereistoxin	CHRNA10 CHRNA2 CHRNA4	9.21e-06	13	74	3	CID000015401
Drug	1-acetyl-4-methylpiperazine methiodide	CHRNA10 CHRNA2 CHRNA4	9.21e-06	13	74	3	CID004392675
Drug	C-toxiferine-I	CHRNA10 CHRNA2 CHRNA4	9.21e-06	13	74	3	CID005089093
Drug	bipinnatin-C	CHRNA10 CHRNA2 CHRNA4	9.21e-06	13	74	3	CID000129977
Drug	bipinnatin-A	CHRNA10 CHRNA2 CHRNA4	9.21e-06	13	74	3	CID000196603
Drug	2,3-dichlorooctafluorobutane	CHRNA10 CHRNA2 CHRNA4	1.17e-05	14	74	3	CID000078982
Drug	LNF 209	CHRNA10 CHRNA2 CHRNA4	1.17e-05	14	74	3	CID000132666
Drug	DB08181	AGA SPRY4 CHRNA10 CHRNA2 CHRNA4	1.32e-05	93	74	5	CID005326798
Drug	3H-diazirine	CHRNA10 CHRNA2 CHRNA4 SLC2A1	1.38e-05	45	74	4	CID000078958
Drug	aa373	CHRNA10 CHRNA2 CHRNA4	1.46e-05	15	74	3	CID000191672
Drug	anatoxin-a hydrochloride	CHRNA10 CHRNA2 CHRNA4	1.46e-05	15	74	3	CID000135265
Drug	(-)-pictamine	CHRNA10 CHRNA2 CHRNA4	1.46e-05	15	74	3	CID006918623
Drug	(-)-lepadin B	CHRNA10 CHRNA2 CHRNA4	1.46e-05	15	74	3	CID006918624
Drug	SAD-128	CHRNA10 CHRNA2 CHRNA4	1.46e-05	15	74	3	CID000162008
Drug	UB-165	CHRNA10 CHRNA2 CHRNA4	1.46e-05	15	74	3	CID004694339
Drug	N-methylcytisine	CHRNA10 CHRNA2 CHRNA4	1.46e-05	15	74	3	CID000234566
Drug	3-(trifluoromethyl)-3-(m-iodophenyl)diazirine	CHRNA10 CHRNA2 CHRNA4	1.79e-05	16	74	3	CID000123866
Drug	AC1L2SVN	CHRNA10 CHRNA2 CHRNA4	1.79e-05	16	74	3	CID000127922
Drug	benzoquinonium	CHRNA10 CHRNA2 CHRNA4	1.79e-05	16	74	3	CID000009393
Drug	PNU-282,987	CHRNA10 CHRNA2 CHRNA4	1.79e-05	16	74	3	CID004655349
Drug	neuroNal	CHRNA10 OMG CHRNA2 CHRNA4	1.95e-05	49	74	4	CID000010535
Drug	Nsc36388	CHRNA10 CHRNA2 CHRNA4	2.17e-05	17	74	3	CID000014954
Drug	AC1O8PVM	CHRNA10 CHRNA2 CHRNA4	2.60e-05	18	74	3	CID000004989
Drug	benzetimide	CHRNA10 CHRNA2 CHRNA4	2.60e-05	18	74	3	CID000021846
Drug	ABT-594	CHRNA10 CHRNA2 CHRNA4	2.60e-05	18	74	3	CID003075702
Drug	AC1LCVGE	CHRNA10 CHRNA2 CHRNA4	2.60e-05	18	74	3	CID000656712
Drug	AC1L9P88	CHRNA10 CHRNA2 CHRNA4	3.08e-05	19	74	3	CID000450860
Drug	isoarecolone	CHRNA10 CHRNA2 CHRNA4	3.08e-05	19	74	3	CID000146970
Drug	beta-erythroidine	CHRNA10 CHRNA2 CHRNA4	3.08e-05	19	74	3	CID000010074
Drug	perhydrohistrionicotoxin	CHRNA10 CHRNA2 CHRNA4	3.08e-05	19	74	3	CID000107881
Drug	PNU-120596	CHRNA10 CHRNA2 CHRNA4	3.08e-05	19	74	3	CID000311434
Drug	4-(N-maleimido)benzyltrimethylammonium	CHRNA10 CHRNA2 CHRNA4	3.08e-05	19	74	3	CID000162425
Drug	sazetidine-A	CHRNA2 CHRNA4	3.12e-05	3	74	2	ctd:C514816
Drug	AC1Q5X7V	CHRNA10 CHRNA2 CHRNA4	3.61e-05	20	74	3	CID000050190
Drug	3-(2-azetidinylmethoxy)pyridine	CHRNA10 CHRNA2 CHRNA4	3.61e-05	20	74	3	CID000001962
Drug	Dichloride, Alcuronium	CHRNA10 CHRNA2 CHRNA4	3.61e-05	20	74	3	CID003032788
Drug	dinotefuran	CHRNA10 CHRNA2 CHRNA4	4.20e-05	21	74	3	CID000197701
Drug	meproadifen	CHRNA10 CHRNA2 CHRNA4	4.20e-05	21	74	3	CID000189752
Drug	Benzamil hydrochloride [2898-76-2]; Down 200; 11.2uM; MCF7; HT_HG-U133A	SLC22A14 KCNN2 SLC7A7 PLPPR2 SLC2A1 RYR2	4.42e-05	197	74	6	3635_DN
Drug	suberyldicholine	CHRNA10 CHRNA2 CHRNA4	4.85e-05	22	74	3	CID000123989
Drug	AR-R17779	CHRNA10 CHRNA2 CHRNA4	4.85e-05	22	74	3	CID005310971
Drug	histrionicotoxin	CHRNA10 CHRNA2 CHRNA4	4.85e-05	22	74	3	CID005282247
Drug	clothianidin	CHRNA10 CHRNA2 CHRNA4	4.85e-05	22	74	3	CID000213027
Drug	kynurenic acid	ADGRE5 CHRNA10 KYNU CHRNA2 CHRNA4	4.88e-05	122	74	5	CID000003845
Drug	Clorocruoro Hem	MPO CHRNA10 CHRNA2 CHRNA4 RYR2	5.07e-05	123	74	5	CID003518809
Drug	AC1L3BL8	CHRNA10 CHRNA2 CHRNA4	5.57e-05	23	74	3	CID000086457
Drug	alpha-conotoxin ImI	CHRNA10 CHRNA2 CHRNA4	5.57e-05	23	74	3	CID000133011
Drug	CID6325740	CHRNA10 CHRNA2 CHRNA4	5.57e-05	23	74	3	CID006325740
Drug	ABT-418	CHRNA10 CHRNA2 CHRNA4	5.57e-05	23	74	3	CID000119380
Drug	alpha-conotoxin SI	CHRNA10 CHRNA2 CHRNA4	5.57e-05	23	74	3	CID000163979
Drug	Skpymrfamide	CHRNA10 CHRNA2 CHRNA4	5.57e-05	23	74	3	CID000132661
Drug	Ultracet	CHRNA10 CHRNA2 CREB3L1 CHRNA4	5.64e-05	64	74	4	CID000005523
Drug	succinylcholine	CHRNA10 CHRNA2 CHRNA4 RYR2	5.64e-05	64	74	4	CID000005314
Drug	beta-erythroidine	CHRNA2 CHRNA4	6.23e-05	4	74	2	ctd:C004873
Drug	AC1NRC6D	SLC7A7 MOG	6.23e-05	4	74	2	CID005288835
Drug	procyclidine	CHRNA10 CHRNA2 CHRNA4	6.35e-05	24	74	3	CID000004919
Drug	AC1L2IZE	CHRNA10 CHRNA2 CHRNA4	6.35e-05	24	74	3	CID000072928
Drug	intruder	CHRNA10 CHRNA2 CHRNA4	6.35e-05	24	74	3	CID000213021
Drug	anabasine	CHRNA10 CHRNA2 CHRNA4	7.20e-05	25	74	3	CID000002181
Drug	varenicline	CHRNA10 CHRNA2 CHRNA4	7.20e-05	25	74	3	CID000170361
Drug	PrBCM	CHRNA10 CHRNA2 CHRNA4	7.20e-05	25	74	3	CID000037396
Drug	pempidine	CHRNA10 CHRNA2 CHRNA4	7.20e-05	25	74	3	CID000006603
Drug	ptaquiloside	FZD1 INHA FAT3 PCDH15 SLC38A11	7.36e-05	133	74	5	ctd:C043680
Drug	benzquinamide	CHRNA10 CHRNA2 CHRNA4	8.12e-05	26	74	3	CID000002342
Drug	AC1O0V2G	CHRNA10 CHRNA2 CHRNA4	8.12e-05	26	74	3	CID006102809
Drug	beta-eudesmol	CHRNA10 CHRNA2 CHRNA4	8.12e-05	26	74	3	CID000091457
Drug	curarine	CHRNA10 CHRNA2 CHRNA4	8.12e-05	26	74	3	CID000198004
Drug	imidazolidine	CHRNA10 CHRNA2 CHRNA4	8.12e-05	26	74	3	CID000449488
Drug	Tubocurarine,d	KCNN2 CHRNA10 CHRNA2 CHRNA4	8.95e-05	72	74	4	CID000001210
Drug	cytidine 5'-diphosphocholine	SCAP CHRNA10 OMG CHRNA2 CHRNA4	9.06e-05	139	74	5	CID000000291
Drug	methylcarbamylcholine	CHRNA10 CHRNA2 CHRNA4	9.11e-05	27	74	3	CID000004136
Drug	nornicotine	CHRNA10 CHRNA2 CHRNA4	9.11e-05	27	74	3	CID000000412
Drug	echothiophate	CHRNA10 CHRNA2 CHRNA4	1.02e-04	28	74	3	CID000010547
Drug	pentolinium	CHRNA10 CHRNA2 CHRNA4	1.02e-04	28	74	3	CID000005849
Drug	nicardipine	AGA CHRNA10 CHRNA2 CHRNA4 RYR2	1.11e-04	145	74	5	CID000004473
Drug	bifemelane	CHRNA10 CHRNA2 CHRNA4	1.13e-04	29	74	3	CID000002377
Drug	bromoacetylcholine bromide	CHRNA10 CHRNA2 CHRNA4	1.13e-04	29	74	3	CID000204966
Drug	M-Hb	SPRY4 CHRNA10 CHRNA2 CHRNA4	1.16e-04	77	74	4	CID006122542
Drug	vecuronium	CHRNA10 CHRNA2 CHRNA4	1.26e-04	30	74	3	CID000039764
Drug	AC1L1BQX	SCAP CHRNA10 CHRNA2 CHRNA4	1.28e-04	79	74	4	CID000001565
Drug	fenoxycarb	KCNN2 CHRNA10 CHRNA2 CHRNA4	1.35e-04	80	74	4	CID000051605
Drug	tetrahydrodeoxycortisol	CHRNA10 CHRNA2 CHRNA4	1.39e-04	31	74	3	CID000010593
Drug	AC1L1JK6	CHRNA10 CHRNA2 CHRNA4	1.39e-04	31	74	3	CID000005077
Drug	quinuclidine	CHRNA10 CHRNA2 CHRNA4	1.39e-04	31	74	3	CID000007527
Disease	Autosomal dominant nocturnal frontal lobe epilepsy	CHRNA2 CHRNA4	3.32e-05	4	70	2	cv:C3696898
Disease	Autosomal Dominant Nocturnal Frontal Lobe Epilepsy	CHRNA2 CHRNA4	1.16e-04	7	70	2	C3696898
Disease	macrophage inflammatory protein 1b measurement	SCAP FTMT PCBP4 PTH1R	3.13e-04	136	70	4	EFO_0008219
Disease	lentiform nucleus measurement	SLC39A1 DENND4B	4.96e-04	14	70	2	EFO_0004913
Disease	dystonia (is_implicated_in)	AOPEP KCNN2	4.96e-04	14	70	2	DOID:543 (is_implicated_in)
Disease	response to platinum based chemotherapy, magnesium measurement	PCDH15 CHRNA4	5.71e-04	15	70	2	EFO_0004647, EFO_0004845
Disease	congenital myasthenic syndrome (implicated_via_orthology)	CHRNA2 CHRNA4	6.52e-04	16	70	2	DOID:3635 (implicated_via_orthology)
Disease	Lung diseases	MPO ADGRE5 PTH1R	8.56e-04	78	70	3	C0024115
Disease	colorectal health	KCNB1 KCNB2 MOG RYR2	1.35e-03	201	70	4	EFO_0008460
Disease	amygdala volume change measurement, age at assessment	FZD6 AOPEP	1.74e-03	26	70	2	EFO_0008007, EFO_0021490
Disease	S-6-hydroxywarfarin measurement	CBLN2 SPRY4 PCDH15 TMEM131L KCNB2	1.83e-03	368	70	5	EFO_0803326
Disease	energy expenditure	KCNB1 PATJ	1.87e-03	27	70	2	EFO_0005109
Disease	C-reactive protein measurement	RNF144B UBR2 AOPEP PCDH15 PRR30 PATJ KCNB2 CREB3L1 PTH1R	2.14e-03	1206	70	9	EFO_0004458
Disease	Child Development Disorders, Specific	CHRNA4 SLC2A1	2.16e-03	29	70	2	C0085997
Disease	Child Development Deviations	CHRNA4 SLC2A1	2.16e-03	29	70	2	C0085996
Disease	Developmental Disabilities	CHRNA4 SLC2A1	2.31e-03	30	70	2	C0008073

Protein segments in the cluster

Peptide	Gene	Start	Entry
CNLLLPCVLISLLAP	CHRNA10	241	Q9GZZ6
IIPCLLISCLTVLVF	CHRNA4	251	P43681
LCFVLVLGSLVPCLP	CREB3L1	381	Q96BA8
YFVPLLLLVPLLLCC	ANTXRL	356	A6NF34
LLVRPVSDCSTLPCL	CIITA	171	P33076
CLLLCILTFLLVRPI	ADGRE5	561	P48960
NLIIPCLLISCLTVL	CHRNA2	271	Q15822
ACQETLLRLIPPCLS	AOPEP	411	Q8N6M6
QLCCYPGPVLLLRRT	ABHD16B	306	Q9H3Z7
PRLVCASLFLRLLCP	RASAL3	601	Q86YV0
VTSPLLLLASPCIIC	RNF144B	271	Q7Z419
LCVRQICAVILESPP	PCBP4	161	P57723
PVVCDPLCTFILLLR	GLIPR1L2	246	Q4G1C9
PLCTFILLLRILCFI	GLIPR1L2	251	Q4G1C9
CIVLPFCPESPRFLL	SLC2A1	201	P11166
FICLEILVCAIHPIP	KCNN2	216	Q9H2S1
PSALLLLCVPGCLTV	CD300H	11	A0A0K2S4Q6
CCVPARLSPISVLFF	GDF1	336	P27539
VSLDLIIPFLRPGCC	IL17RE	416	Q8NFR9
PGFAITIIALCCLPL	DUOX2	596	Q9NRD8
TIIALCCLPLVSLLL	DUOX2	601	Q9NRD8
VLCCPPIALRNLIII	CD200R1L	51	Q6Q8B3
PCLLTNRSARIPCFL	MPO	386	P05164
ILVLLCAFLIPCPPR	FAM234B	116	A2RU67
LVLVPTLCPLCEEHR	MEGF8	891	Q7Z7M0
ALCELPELRCIEFPV	LRRC14B	411	A6NHZ5
LLLCSPCLLIQIPEE	L1CAM	11	P32004
RPSLPSCLCSFLLLL	MOG	6	Q16653
LFCVGPLPCTLLLTL	SMPD4	831	Q9NXE4
LLPVTPRLCLACALE	MEI1	36	Q5TIA1
VKPSLCLALLCPAFL	PLPPR2	236	Q96GM1
ALLALAFIIILCCIP	PCDH15	1376	Q96QU1
AFIIILCCIPAILVV	PCDH15	1381	Q96QU1
VCTVLEQALPPCRSL	FZD1	176	Q9UP38
VLLPLCLCVFVGLSL	FZD6	371	O60353
LCCIAGVLVIALPIP	KCNB1	396	Q14721
CCIAGVLVIALPIPI	KCNB2	401	Q92953
LLCCLSLPILAVPIA	C5AR2	81	Q9P296
ITPVLLLCICRPLGQ	GPR37L1	411	O60883
TRPPACCLILLLFKL	FAT3	11	Q8TDW7
VSVCLLLLCPREVIA	IGFL2	11	Q6UWQ7
LALLLLLLPACCPVR	CBLN2	36	Q8IUK8
LCQALVRCSSPLPLV	AGA	16	P20933
CPYIPLCPLVLADVL	DENND4B	451	O75064
HPVLVLLLRCPLCTC	INHA	191	P05111
CLLLDLLVCFSRPPG	ENGASE	576	Q8NFI3
LLRELCSTPVPTLFC	ERMARD	511	Q5T6L9
TPSLLPIFLCCVLAI	SLC22A14	536	Q9Y267
PIPIILFTGFCILAC	SCAP	26	Q12770
LLLDVACPARTCPVL	S1PR5	271	Q9H228
VLCATPLIFIIPSAC	SLC38A11	311	Q08AI6
CTAVLPLLTRCAPLF	RYR2	2521	Q92736
LASLRPVRCCFALPL	FTMT	16	Q8N4E7
CLPLPVCKRLCTERQ	RGPD1	506	P0DJD0
FCIILPDVFLLTCLP	OR52H1	161	Q8NGJ2
PDVFLLTCLPFCRTR	OR52H1	166	Q8NGJ2
LSVVLPCLLCYLPAT	SPRY4	241	Q9C004
LLLGVFQVLLPCCRP	TMEM131L	21	A2VDJ0
TVFLPRCHPLPCILD	FAM178B	266	Q8IXR5
LFQIVPVTCPICVSL	RNF138	181	Q8WVD3
CLFILLFLTPGILCI	OMG	11	P23515
KCPVCGSLFREPIIL	TRIM67	6	Q6ZTA4
LVCLGLVCLSVLLFP	TAS1R3	611	Q7RTX0
TCIPAIVCLGFLLLL	TMEM35B	111	Q8NCS4
VLVCLTCILAILIPR	SLC36A1	381	Q7Z2H8
IAPGLALLLCCPVLS	PTH1R	6	Q03431
EVPPPFTLVCCRRLF	PATJ	626	Q8NI35
TLLCSLVPICVLRRP	SLC39A1	41	Q9NY26
IFLLACPPCRGAIVV	TMEM164	131	Q5U3C3
CCLPVPDLRLLLVAE	WDR97	201	A6NE52
LLPSPLFLIRICGVC	SPATA31D1	591	Q6ZQQ2
PIVFCLCTIFLVAVP	SLC7A7	421	Q9UM01
PFPDVLECCLVLLLI	GEMIN5	1456	Q8TEQ6
LVEIDFRCNCVPIPL	TLR7	91	Q9NYK1
FLRPTVCIQVCPFSL	USP31	501	Q70CQ4
VVEYPICLVCLRPRS	PRR30	246	Q53SZ7
PLCECLSNTVIPLLL	UBR2	1211	Q8IWV8
RVLLALFCHEPCRPL	TRIM28	706	Q13263
LLCVCVVPLPDHLCR	WDR64	211	B1ANS9
VCGFRISNPPILLVC	KYNU	326	Q16719