Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	bitter taste receptor activity	TAS2R33 TAS2R45 TAS2R31 TAS2R43	6.83e-06	27	92	4	GO:0033038
GeneOntologyMolecularFunction	taste receptor activity	TAS2R33 TAS2R45 TAS2R31 TAS2R43	1.56e-05	33	92	4	GO:0008527
GeneOntologyMolecularFunction	translation termination factor activity	GSPT2 GSPT1	4.34e-04	7	92	2	GO:0008079
GeneOntologyMolecularFunction	translation release factor activity	GSPT2 GSPT1	4.34e-04	7	92	2	GO:0003747
GeneOntologyMolecularFunction	translation factor activity, RNA binding	EEFSEC GSPT2 GSPT1 EIF3CL	6.43e-04	85	92	4	GO:0008135
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception of bitter taste	TAS2R33 TAS2R45 TAS2R31 TAS2R43	4.03e-05	44	90	4	GO:0001580
GeneOntologyBiologicalProcess	regulation of secretory granule organization	OSBP PTBP1	5.63e-05	3	90	2	GO:1904409
GeneOntologyBiologicalProcess	positive regulation of secretory granule organization	OSBP PTBP1	5.63e-05	3	90	2	GO:1904411
GeneOntologyBiologicalProcess	sensory perception of bitter taste	TAS2R33 TAS2R45 TAS2R31 TAS2R43	5.69e-05	48	90	4	GO:0050913
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception of taste	TAS2R33 TAS2R45 TAS2R31 TAS2R43	6.70e-05	50	90	4	GO:0050912
GeneOntologyCellularComponent	translation release factor complex	GSPT2 GSPT1	5.61e-05	3	91	2	GO:0018444
HumanPheno	Cutaneous photosensitivity	CYBB ERCC5 ERCC6L2 C4A C4B ALAS2	2.70e-05	118	27	6	HP:0000992
HumanPheno	Discoid lupus rash	CYBB DOCK11 C4A C4B	4.54e-05	39	27	4	HP:0007417
Domain	HnRNP-L/PTB	PTBP3 PTBP2 PTBP1	1.04e-06	5	89	3	IPR006536
Domain	Thiol-ester_cl	A2ML1 C4A C4B	5.76e-06	8	89	3	PF10569
Domain	MacrogloblnA2_thiol-ester-bond	A2ML1 C4A C4B	5.76e-06	8	89	3	IPR019565
Domain	MacrogloblnA2_CS	A2ML1 C4A C4B	5.76e-06	8	89	3	IPR019742
Domain	A2M_N	A2ML1 C4A C4B	1.23e-05	10	89	3	PF01835
Domain	A2M_N	A2ML1 C4A C4B	1.23e-05	10	89	3	IPR002890
Domain	A-macroglobulin_rcpt-bd	A2ML1 C4A C4B	1.23e-05	10	89	3	IPR009048
Domain	ALPHA_2_MACROGLOBULIN	A2ML1 C4A C4B	1.23e-05	10	89	3	PS00477
Domain	A2M	A2ML1 C4A C4B	1.23e-05	10	89	3	PF00207
Domain	A2M_N_2	A2ML1 C4A C4B	1.23e-05	10	89	3	IPR011625
Domain	A2M_comp	A2ML1 C4A C4B	1.23e-05	10	89	3	IPR011626
Domain	A2M_N_2	A2ML1 C4A C4B	1.23e-05	10	89	3	PF07703
Domain	A2M_recep	A2ML1 C4A C4B	1.23e-05	10	89	3	PF07677
Domain	A2M_comp	A2ML1 C4A C4B	1.23e-05	10	89	3	PF07678
Domain	Macroglobln_a2	A2ML1 C4A C4B	1.23e-05	10	89	3	IPR001599
Domain	G_TR_1	EEFSEC GSPT2 GSPT1	2.89e-05	13	89	3	PS00301
Domain	EFTu-like_2	EEFSEC GSPT2 GSPT1	8.10e-05	18	89	3	IPR004161
Domain	Terpenoid_cyclase/PrenylTrfase	A2ML1 C4A C4B	8.10e-05	18	89	3	IPR008930
Domain	GTP_EFTU_D2	EEFSEC GSPT2 GSPT1	8.10e-05	18	89	3	PF03144
Domain	G_TR_2	EEFSEC GSPT2 GSPT1	8.10e-05	18	89	3	PS51722
Domain	TF_GTP-bd_dom	EEFSEC GSPT2 GSPT1	9.59e-05	19	89	3	IPR000795
Domain	Anaphylatoxin_comp_syst	C4A C4B	2.22e-04	5	89	2	IPR018081
Domain	Anaphylatoxn_comp_syst_dom	C4A C4B	2.22e-04	5	89	2	IPR001840
Domain	TAS2R	TAS2R45 TAS2R31 TAS2R43	2.51e-04	26	89	3	PF05296
Domain	T2R	TAS2R45 TAS2R31 TAS2R43	2.51e-04	26	89	3	IPR007960
Domain	Transl_B-barrel	EEFSEC GSPT2 GSPT1	2.82e-04	27	89	3	IPR009000
Domain	ANATO	C4A C4B	4.64e-04	7	89	2	SM00104
Domain	ANATO	C4A C4B	4.64e-04	7	89	2	PF01821
Domain	Thioestr_dom	ACOT11 ACOT13	4.64e-04	7	89	2	IPR006683
Domain	ANAPHYLATOXIN_2	C4A C4B	4.64e-04	7	89	2	PS01178
Domain	ANAPHYLATOXIN_1	C4A C4B	4.64e-04	7	89	2	PS01177
Domain	4HBT	ACOT11 ACOT13	4.64e-04	7	89	2	PF03061
Domain	Anaphylatoxin/fibulin	C4A C4B	4.64e-04	7	89	2	IPR000020
Domain	Transl_elong_EFTu/EF1A_C	GSPT2 GSPT1	6.17e-04	8	89	2	IPR004160
Domain	A2M_N_2	A2ML1 C4A	6.17e-04	8	89	2	SM01359
Domain	-	A2ML1 C4A	6.17e-04	8	89	2	2.60.40.690
Domain	GTP_EFTU_D3	GSPT2 GSPT1	6.17e-04	8	89	2	PF03143
Domain	A2M_recep	A2ML1 C4A	6.17e-04	8	89	2	SM01361
Domain	A2M	A2ML1 C4A	6.17e-04	8	89	2	SM01360
Domain	G_TR_CS	GSPT2 GSPT1	7.91e-04	9	89	2	IPR031157
Domain	Transl_elong_EF1A/Init_IF2_C	GSPT2 GSPT1	9.86e-04	10	89	2	IPR009001
Domain	HotDog_dom	ACOT11 ACOT13	9.86e-04	10	89	2	IPR029069
Domain	-	ACOT11 ACOT13	9.86e-04	10	89	2	3.10.129.10
Domain	-	HSPA4L HSPA4	1.44e-03	12	89	2	2.60.34.10
Domain	HSP70_peptide-bd	HSPA4L HSPA4	1.44e-03	12	89	2	IPR029047
Domain	-	A2ML1 C4A	1.44e-03	12	89	2	1.50.10.20
Domain	-	HSPA4L HSPA4	1.69e-03	13	89	2	1.20.1270.10
Domain	Heat_shock_70_CS	HSPA4L HSPA4	1.69e-03	13	89	2	IPR018181
Domain	HSP70_C	HSPA4L HSPA4	1.69e-03	13	89	2	IPR029048
Domain	PINT	PSMD3 EIF3CL	2.58e-03	16	89	2	SM00088
Domain	HSP70	HSPA4L HSPA4	2.58e-03	16	89	2	PF00012
Domain	C345C	C4A C4B	2.91e-03	17	89	2	SM00643
Domain	HSP70_2	HSPA4L HSPA4	2.91e-03	17	89	2	PS00329
Domain	PCI_dom	PSMD3 EIF3CL	2.91e-03	17	89	2	IPR000717
Domain	PCI	PSMD3 EIF3CL	2.91e-03	17	89	2	PF01399
Domain	HSP70_3	HSPA4L HSPA4	2.91e-03	17	89	2	PS01036
Domain	HSP70_1	HSPA4L HSPA4	2.91e-03	17	89	2	PS00297
Domain	Hsp_70_fam	HSPA4L HSPA4	3.27e-03	18	89	2	IPR013126
Domain	NTR	C4A C4B	3.64e-03	19	89	2	PF01759
Domain	Netrin_module_non-TIMP	C4A C4B	3.64e-03	19	89	2	IPR018933
Pubmed	Expression of human nPTB is limited by extreme suboptimal codon content.	PTBP3 PTBP2 PTBP1	1.79e-08	3	92	3	18335065
Pubmed	PTBP1 is required for embryonic development before gastrulation.	PTBP3 PTBP2 PTBP1	1.78e-07	5	92	3	21423341
Pubmed	Polypyrimidine tract-binding proteins are essential for B cell development.	PTBP3 PTBP2 PTBP1	1.78e-07	5	92	3	32081131
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	IGF2R GUCY1B2 HSPA4L CEBPZ ACOT13 SYNE1 UBR4 PSMD3 HEATR1 MYO18B PTBP1 HSPA4 TFCP2 GSPT1 EIF3CL NPAS2	9.68e-07	1425	92	16	30948266
Pubmed	The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides.	TAS2R45 TAS2R31 TAS2R43	3.87e-06	12	92	3	12379855
Pubmed	Haplotypes at the Tas2r locus on distal chromosome 6 vary with quinine taste sensitivity in inbred mice.	TAS2R45 TAS2R31 TAS2R43	5.03e-06	13	92	3	15938754
Pubmed	Copy number analysis of complement C4A, C4B and C4A silencing mutation by real-time quantitative polymerase chain reaction.	C4A C4B	6.92e-06	2	92	2	22737222
Pubmed	Deficiency of C4 from donor or recipient mouse fails to prevent renal allograft rejection.	C4A C4B	6.92e-06	2	92	2	16565498
Pubmed	Complete deficiencies of complement C4A and C4B including 2-bp insertion in codon 1213 are genetic risk factors of systemic lupus erythematosus in Thai populations.	C4A C4B	6.92e-06	2	92	2	15998580
Pubmed	Structural polymorphism of murine C4 and its linkage to H-2.	C4A C4B	6.92e-06	2	92	2	7373044
Pubmed	High-throughput analysis of the C4 polymorphism by a combination of MLPA and isotype-specific ELISA's.	C4A C4B	6.92e-06	2	92	2	19062096
Pubmed	The chemical structure of the C4d fragment of the human complement component C4.	C4A C4B	6.92e-06	2	92	2	3696167
Pubmed	Specific alleles of bitter receptor genes influence human sensitivity to the bitterness of aloin and saccharin.	TAS2R31 TAS2R43	6.92e-06	2	92	2	17702579
Pubmed	Restriction fragment length polymorphism of the murine C4 and Slp genes: two C4 groups.	C4A C4B	6.92e-06	2	92	2	1357031
Pubmed	Structural comparison of human C4A3 and C4B1 after proteolytic activation by C1s.	C4A C4B	6.92e-06	2	92	2	16098595
Pubmed	Activation of innate and humoral immunity in the peripheral nervous system of ALS transgenic mice.	C4A C4B	6.92e-06	2	92	2	19933335
Pubmed	Structural basis for the C4d.1/C4d.2 serologic allotypes of murine complement component C4.	C4A C4B	6.92e-06	2	92	2	2459207
Pubmed	Antigen-induced B cell apoptosis is independent of complement C4.	C4A C4B	6.92e-06	2	92	2	17645767
Pubmed	Increased frequency of C4B*Q0 alleles in patients with Henoch-Schönlein purpura.	C4A C4B	6.92e-06	2	92	2	15787745
Pubmed	Anti-DNA autoreactivity in C4-deficient mice.	C4A C4B	6.92e-06	2	92	2	12207352
Pubmed	Alternative splicing of brain-specific PTB defines a tissue-specific isoform pattern that predicts distinct functional roles.	PTBP2 PTBP1	6.92e-06	2	92	2	12213192
Pubmed	Neuropil contraction in relation to Complement C4 gene copy numbers in independent cohorts of adolescent-onset and young adult-onset schizophrenia patients-a pilot study.	C4A C4B	6.92e-06	2	92	2	30026462
Pubmed	A molecular map of the human major histocompatibility complex class III region linking complement genes C4, C2 and factor B.	C4A C4B	6.92e-06	2	92	2	6559257
Pubmed	Complement C4A and C4B Gene Copy Number Study in Alzheimer's Disease Patients.	C4A C4B	6.92e-06	2	92	2	27758680
Pubmed	Genetically determined partial complement C4 deficiency states are not independent risk factors for SLE in UK and Spanish populations.	C4A C4B	6.92e-06	2	92	2	22387014
Pubmed	Complement C4 Is Reduced in iPSC-Derived Astrocytes of Autism Spectrum Disorder Subjects.	C4A C4B	6.92e-06	2	92	2	34299197
Pubmed	Assessment of complement C4 gene copy number using the paralog ratio test.	C4A C4B	6.92e-06	2	92	2	20506482
Pubmed	PTBP1 and PTBP2 Repress Nonconserved Cryptic Exons.	PTBP2 PTBP1	6.92e-06	2	92	2	27681424
Pubmed	Cloning of human cDNAs for Apg-1 and Apg-2, members of the Hsp110 family, and chromosomal assignment of their genes.	HSPA4L HSPA4	6.92e-06	2	92	2	10524232
Pubmed	Involvement of human release factors eRF3a and eRF3b in translation termination and regulation of the termination complex formation.	GSPT2 GSPT1	6.92e-06	2	92	2	15987998
Pubmed	Polymerase chain reaction based C4AQ0 and C4BQ0 genotyping: association with systemic lupus erythematosus in southwest Han Chinese.	C4A C4B	6.92e-06	2	92	2	12480675
Pubmed	Low C4, C4A and C4B gene copy numbers are stronger risk factors for juvenile-onset than for adult-onset systemic lupus erythematosus.	C4A C4B	6.92e-06	2	92	2	26800705
Pubmed	Complement C4 maintains peripheral B-cell tolerance in a myeloid cell dependent manner.	C4A C4B	6.92e-06	2	92	2	23749435
Pubmed	Copy number variations of complement component C4 are associated with Behçet's disease but not with ankylosing spondylitis associated with acute anterior uveitis.	C4A C4B	6.92e-06	2	92	2	23918728
Pubmed	Murine complement C4 is not required for experimental autoimmune encephalomyelitis.	C4A C4B	6.92e-06	2	92	2	15390104
Pubmed	Molecular genetics of androgen-dependent and -independent expression of mouse sex-limited protein.	C4A C4B	6.92e-06	2	92	2	3037333
Pubmed	Evidence of a role for C4 in modulating interstitial inflammation in experimental glomerulonephritis.	C4A C4B	6.92e-06	2	92	2	11726230
Pubmed	Quantitative variations in the expression of the mouse serum antigen Ss and its sex-limited allotype Slp.	C4A C4B	6.92e-06	2	92	2	4216347
Pubmed	Importance of the alpha 3-fragment of complement C4 for the binding with C4b-binding protein.	C4A C4B	6.92e-06	2	92	2	1699796
Pubmed	Sequence determination of the thiolester site of the fourth component of human complement.	C4A C4B	6.92e-06	2	92	2	6950384
Pubmed	Molecular cloning and characterization of complementary and genomic DNA clones for mouse C4 and Slp.	C4A C4B	6.92e-06	2	92	2	2997024
Pubmed	Visual demonstration of the organization of the human complement C4 and 21-hydroxylase genes by high-resolution fluorescence in situ hybridization.	C4A C4B	6.92e-06	2	92	2	8660986
Pubmed	Constitutive expression of Slp genes in mouse strain B10.WR directed by C4 regulatory sequences.	C4A C4B	6.92e-06	2	92	2	3624865
Pubmed	Tissue-specific RNA processing for the complement C4 gene transcript in the H-2k mouse strain.	C4A C4B	6.92e-06	2	92	2	8428773
Pubmed	Determination of the loss of function complement C4 exon 29 CT insertion using a novel paralog-specific assay in healthy UK and Spanish populations.	C4A C4B	6.92e-06	2	92	2	21857912
Pubmed	Complement C4 deficiency--a plausible risk factor for non-tuberculous mycobacteria (NTM) infection in apparently immunocompetent patients.	C4A C4B	6.92e-06	2	92	2	24638111
Pubmed	Isolation of cDNA clones specifying the fourth component of mouse complement and its isotype, sex-limited protein.	C4A C4B	6.92e-06	2	92	2	6208559
Pubmed	The role of the histocompatibility-2-linked Ss-Slp region in the control of mouse complement.	C4A C4B	6.92e-06	2	92	2	4514997
Pubmed	Transcriptional repression of C4 complement by hepatitis C virus proteins.	C4A C4B	6.92e-06	2	92	2	21345967
Pubmed	The inheritance of susceptibility to the Gross leukemia virus in mice.	C4A C4B	6.92e-06	2	92	2	5919331
Pubmed	An ancient provirus has imposed androgen regulation on the adjacent mouse sex-limited protein gene.	C4A C4B	6.92e-06	2	92	2	3167981
Pubmed	The dichotomous size variation of human complement C4 genes is mediated by a novel family of endogenous retroviruses, which also establishes species-specific genomic patterns among Old World primates.	C4A C4B	6.92e-06	2	92	2	7545960
Pubmed	Human polypyrimidine tract-binding protein interacts with mitochondrial tRNA(Thr) in the cytosol.	PTBP3 PTBP2	6.92e-06	2	92	2	26657638
Pubmed	Insights on the relationship between complement component C4 serum concentrations and C4 gene copy numbers in a Western Australian systemic lupus erythematosus cohort.	C4A C4B	6.92e-06	2	92	2	30041577
Pubmed	Restriction fragment analysis of H-2 recombinant mouse strains with crossovers between E alpha and C4 genes.	C4A C4B	6.92e-06	2	92	2	2572548
Pubmed	The complement component C4 of mammals.	C4A C4B	6.92e-06	2	92	2	2302180
Pubmed	Complete cDNA sequence of the fourth component of murine complement.	C4A C4B	6.92e-06	2	92	2	3862104
Pubmed	The BS variant of C4 protects against age-related loss of white matter microstructural integrity.	C4A C4B	6.92e-06	2	92	2	34358307
Pubmed	Acute renal allograft rejection: diagnostic significance of focal peritubular capillary C4d.	C4A C4B	6.92e-06	2	92	2	18360261
Pubmed	Gene CNVs and protein levels of complement C4A and C4B as novel biomarkers for partial disease remissions in new-onset type 1 diabetes patients.	C4A C4B	6.92e-06	2	92	2	22151770
Pubmed	C4d-positive chronic rejection: a frequent entity with a poor outcome.	C4A C4B	6.92e-06	2	92	2	18091514
Pubmed	Comprehensive approach to study complement C4 in systemic lupus erythematosus: Gene polymorphisms, protein levels and functional activity.	C4A C4B	6.92e-06	2	92	2	29080553
Pubmed	Schizophrenia risk from complex variation of complement component 4.	C4A C4B	6.92e-06	2	92	2	26814963
Pubmed	Genes for murine fourth complement component (C4) and sex-limited protein (Slp) identified by hybridization to C4- and Slp-specific cDNA.	C4A C4B	6.92e-06	2	92	2	6589636
Pubmed	C4 Deficiency is a predisposing factor for Streptococcus pneumoniae-induced autoantibody production.	C4A C4B	6.92e-06	2	92	2	25339671
Pubmed	A study of association of the complement C4 mutations with systemic lupus erythematosus in the Malaysian population.	C4A C4B	6.92e-06	2	92	2	17728371
Pubmed	Bitter taste receptors for saccharin and acesulfame K.	TAS2R31 TAS2R43	6.92e-06	2	92	2	15537898
Pubmed	Structure and organization of the C4 genes.	C4A C4B	6.92e-06	2	92	2	6149580
Pubmed	Sequence heterogeneity of murine complementary DNA clones related to the C4 and C4-Slp isoforms of the fourth complement component.	C4A C4B	6.92e-06	2	92	2	6149581
Pubmed	The follicular dendritic cell restricted epitope, FDC-M2, is complement C4; localization of immune complexes in mouse tissues.	C4A C4B	6.92e-06	2	92	2	12115608
Pubmed	Biochemistry and biology of anaphylatoxins.	C4A C4B	6.92e-06	2	92	2	3542363
Pubmed	C4 from C4-high and C4-low mouse strains have identical sequences in the region corresponding to the isotype-specific segment of human C4.	C4A C4B	6.92e-06	2	92	2	2387317
Pubmed	Promoter elements of the mouse complement C4 gene critical for transcription activation and start site location.	C4A C4B	6.92e-06	2	92	2	8132550
Pubmed	Substitution of a single amino acid (aspartic acid for histidine) converts the functional activity of human complement C4B to C4A.	C4A C4B	6.92e-06	2	92	2	2395880
Pubmed	Effects of Complement C4 Gene Copy Number Variations, Size Dichotomy, and C4A Deficiency on Genetic Risk and Clinical Presentation of Systemic Lupus Erythematosus in East Asian Populations.	C4A C4B	6.92e-06	2	92	2	26814708
Pubmed	cDNA clone spanning the alpha-gamma subunit junction in the precursor of the murine fourth complement component (C4).	C4A C4B	6.92e-06	2	92	2	6192448
Pubmed	Complete primary structure of human C4a anaphylatoxin.	C4A C4B	6.92e-06	2	92	2	6167582
Pubmed	Identification of the size and antigenic determinants of the human C4 gene by a polymerase chain-reaction-based amplification method.	C4A C4B	6.92e-06	2	92	2	16908004
Pubmed	Slp is an essential component of an EDTA-resistant activation pathway of mouse complement.	C4A C4B	6.92e-06	2	92	2	1438267
Pubmed	Structural studies on the murine fourth component of complement (C4). IV. Demonstration that C4 and Slp are encoded by separate loci.	C4A C4B	6.92e-06	2	92	2	7365238
Pubmed	Genetic deficiency of complement isoforms C4A or C4B predicts improved survival of metastatic renal cell carcinoma.	C4A C4B	6.92e-06	2	92	2	19150565
Pubmed	Interaction between the labile binding sites of the fourth (C4) and fifth (C5) human complement proteins and erythrocyte cell membranes.	C4A C4B	6.92e-06	2	92	2	7391573
Pubmed	Elevated levels of endogenous apoptotic DNA and IFN-alpha in complement C4-deficient mice: implications for induction of systemic lupus erythematosus.	C4A C4B	6.92e-06	2	92	2	17506029
Pubmed	Peritubular capillary C4d deposition in lupus nephritis different from antibody-mediated renal rejection.	C4A C4B	6.92e-06	2	92	2	17971360
Pubmed	Low C4 gene copy numbers are associated with superior graft survival in patients transplanted with a deceased donor kidney.	C4A C4B	6.92e-06	2	92	2	23715124
Pubmed	Identification of the 5'-flanking regulatory region responsible for the difference in transcriptional control between mouse complement C4 and Slp genes.	C4A C4B	6.92e-06	2	92	2	3464002
Pubmed	Complete nucleotide and derived amino acid sequences of the fourth component of mouse complement (C4). Evolutionary aspects.	C4A C4B	6.92e-06	2	92	2	2993295
Pubmed	Clinical features of patients with homozygous complement C4A or C4B deficiency.	C4A C4B	6.92e-06	2	92	2	29928053
Pubmed	Analysis of C4 and the C4 binding protein in the MRL/lpr mouse.	C4A C4B	6.92e-06	2	92	2	17971229
Pubmed	Genetic deficiency of C4 presenting with recurrent infections and a SLE-like disease. Genetic and immunologic studies.	C4A C4B	6.92e-06	2	92	2	6881182
Pubmed	Identification of the site of sulfation of the fourth component of human complement.	C4A C4B	6.92e-06	2	92	2	3944109
Pubmed	Streamlined platform for short hairpin RNA interference and transgenesis in cultured mammalian cells.	PTBP2 PTBP1	6.92e-06	2	92	2	21768390
Pubmed	Silencing of SmgGDS, a Novel mTORC1 Inducer That Binds to RHEBs, Inhibits Malignant Mesothelioma Cell Proliferation.	RAP1GDS1 RHEB	6.92e-06	2	92	2	33574130
Pubmed	Functional role of Tia1/Pub1 and Sup35 prion domains: directing protein synthesis machinery to the tubulin cytoskeleton.	GSPT2 GSPT1	6.92e-06	2	92	2	24981173
Pubmed	Partial C4 deficiency in juvenile idiopathic arthritis patients.	C4A C4B	6.92e-06	2	92	2	17921792
Pubmed	Complement activation and complement receptors on follicular dendritic cells are critical for the function of a targeted adjuvant.	C4A C4B	6.92e-06	2	92	2	21880985
Pubmed	Amino acid sequence around the thiol and reactive acyl groups of human complement component C4.	C4A C4B	6.92e-06	2	92	2	6978711
Pubmed	Plasma Complement 3 and Complement 4 Are Promising Biomarkers for Distinguishing NMOSD From MOGAD and Are Associated With the Blood-Brain-Barrier Disruption in NMOSD.	C4A C4B	6.92e-06	2	92	2	35898513
Pubmed	Overexpression of schizophrenia susceptibility factor human complement C4A promotes excessive synaptic loss and behavioral changes in mice.	C4A C4B	6.92e-06	2	92	2	33353966
Pubmed	Sequence comparison of alleles of the fourth component of complement (C4) and sex-limited protein (Slp).	C4A C4B	6.92e-06	2	92	2	3008092
GeneFamily	C3 and PZP like, alpha-2-macroglobulin domain containing	A2ML1 C4A C4B	3.50e-06	9	64	3	1234
GeneFamily	Taste 2 receptors	TAS2R33 TAS2R45 TAS2R31 TAS2R43	1.07e-05	39	64	4	1162
GeneFamily	Acyl-CoA thioesterases	ACOT11 ACOT13	5.45e-04	10	64	2	41
GeneFamily	Heat shock 70kDa proteins	HSPA4L HSPA4	1.62e-03	17	64	2	583
GeneFamily	Calcium voltage-gated channel subunits\|Membrane associated guanylate kinases	DLG5 TJP3	3.80e-03	26	64	2	904
GeneFamily	Complement system\|Sushi domain containing	C4A C4B	7.19e-03	36	64	2	492
GeneFamily	Glycosyltransferase family 6\|Blood group antigens	C4A C4B	7.59e-03	37	64	2	454
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PTBP3 IQCA1 PIK3C2G SLC16A14 CRYBG1 NPAS2	2.58e-06	192	90	6	fd08ae787e936cfdb1ab8f19b0fd63005b462709
Disease	myeloblastin measurement	PSMD3 PTBP1	1.22e-04	6	85	2	EFO_0020585
Disease	phenol sulfate measurement	SLC30A5 MYO18B	2.27e-04	8	85	2	EFO_0021011
Disease	systemic lupus erythematosus (implicated_via_orthology)	CYBB C4A C4B	2.62e-04	43	85	3	DOID:9074 (implicated_via_orthology)
Disease	X-11381 measurement	IGF2R SLC36A2	2.91e-04	9	85	2	EFO_0021228
Disease	serum gamma-glutamyl transferase measurement	SLCO1B7 DLG5 DOCK11 CSNK1G3 TNFRSF10A PTBP1 KDF1 HSPA4 CYP2W1 TJP3	2.97e-04	914	85	10	EFO_0004532
Disease	renal cell carcinoma (is_implicated_in)	C4A C4B TNFRSF10A	1.05e-03	69	85	3	DOID:4450 (is_implicated_in)
Disease	aspartate aminotransferase measurement	DLG5 GFOD1 NIPAL1 ZC3H18 HEPHL1 PTBP1 GSS TJP3 NPAS2	1.18e-03	904	85	9	EFO_0004736
Disease	taurine measurement	MS4A6E KCNK1	2.55e-03	26	85	2	EFO_0010536

Protein segments in the cluster

Peptide	Gene	Start	Entry
LSVKGITKNVHTVSV	TDRD1	1086	Q9BXT4
VITAHVLKQGKTLAF	ACOT13	101	Q9NPJ3
LTHKQGLQAVKSTVI	C2orf16	676	Q68DN1
KITQVLHFTKDVKAA	C4B	1646	P0C0L5
IHKKIIAVNNISIGI	ABCA12	2266	Q86UK0
VKLGHINFTISTKIL	A2ML1	861	A8K2U0
VFTVHLGRQKTVVLT	CYP2W1	66	Q8TAV3
HTISVGQVVNIKAKV	ACOT11	101	Q8WXI4
KHGILFLVVTLVSVF	ALG10B	321	Q5I7T1
FTQGHIVEVVKGVLT	IQCA1	741	Q86XH1
TVHQGVAQLKDFITK	RASA4B	531	C9J798
LIVKSKTVFVGAINI	PIK3C2G	1411	O75747
IGNSLVIHVVIKFKS	NPY2R	66	P49146
ITKVFLGQSVQAHEK	LRRC9	551	Q6ZRR7
TTVLEKVIGFLQKHN	NPAS2	46	Q99743
TVKFLTAISVVKHIV	PAXIP1	911	Q6ZW49
SKVKVKVRVNVHGIF	HSPA4	476	P34932
KQVVAIVHAVLLGFV	KCNK1	176	O00180
LRKIFHRVVGIVQTK	FSIP2	4631	Q5CZC0
AKTAGVKHLIVLINK	GSPT2	336	Q8IYD1
VSGKHILQFVAIKRK	NUDT9	191	Q9BW91
GVLVEHVKNVFITKT	ENPP4	56	Q9Y6X5
RVVFIKKSQLELGVH	DLG5	1501	Q8TDM6
VDATHIGKLIVTKQI	F13A1	456	P00488
LPGFQHVKLSVVKTI	METTL18	121	O95568
QVLVHFLVKRKTISF	OR2D3	96	Q8NGH3
LVKGIFHLTQIKKVR	CHRDL2	371	Q6WN34
KTQQVIHIIDFGLAK	CSNK1G3	176	Q9Y6M4
KKVTTTVHNIIVGKL	OSBP	576	P22059
LAKTAGVKHLIVLIN	GSPT1	206	P15170
LLGKVVKTHQFLFGI	ALAS2	21	P22557
SVTSIKSFEVIKVIH	RHEB	86	Q15382
SKFHIDPITGQIIVK	PCDHA4	291	Q9UN74
HVQVLVLKSKNLVGV	FBXO38	916	Q6PIJ6
KGTEITHAVVIKKLN	EIF3CL	321	B5ME19
TAISVIKNLLIKHAF	DOCK11	1136	Q5JSL3
AVLKGQVETIVSFHI	BCL9	191	O00512
DVIKTIVQSGGIKHL	RAP1GDS1	481	P52306
LQAKVKVIGVHSSLA	MS4A6E	41	Q96DS6
HAEVGNTVLIIFKNK	HEPHL1	816	Q6MZM0
SQQKVVITKVVTHPF	CYBB	291	P04839
FNLKQKVTFHVILSV	HEATR1	696	Q9H583
HIILNTVSKEKFTQV	CRYBG1	1701	Q9Y4K1
TVQVISFLAAVLHKK	ERCC6L2	166	Q5T890
IHKQVLKEGIAQTVF	GSS	106	P48637
FIHAKKVNFTVEVLL	SEC14L2	371	O76054
ITNHETQEGIVILKK	CDH19	306	Q9H159
TIIIGIFLLHAFKNT	NIPAL1	346	Q6NVV3
HTLQFVETLVNLVKK	CEBPZ	261	Q03701
KITQVLHFTKDVKAA	C4A	1646	P0C0L4
VIKQGKIVFVLSSAL	HPD	61	P32754
HTQKLGVIGDKVVVT	IGF2R	2061	P11717
VGLVTNQLSHIKAKI	RTN2	506	O75298
TKVHIKALQTVIFFL	TAS2R31	221	P59538
TKVHIKALQTVISFL	TAS2R33	221	P0DSN6
TKVHIKALQTVISFL	TAS2R43	221	P59537
TKVHIKVLQTVISFF	TAS2R45	221	P59539
VLHQIFSKFGAVLKI	PTBP2	196	Q9UKA9
KALVSVVNSFHEKIV	SYNE1	5146	Q8NF91
TFVKQTDHIKGIRQI	GFOD1	201	Q9NXC2
TSIIAIVHIFGKVIL	SLC16A14	356	Q7RTX9
TSHYILIKGIQAKTV	ERCC5	286	P28715
TGKKEHVVFLIVQKA	GUCY1B2	96	O75343
TKGITVFQALIHLVK	SLC36A2	51	Q495M3
VLLTVFIFVVRKKSH	SLCO1B7	591	G3V0H7
VLIFKKLTELFSVHQ	KDF1	241	Q8NAX2
LNVVKKTLITFVNKH	PARVA	261	Q9NVD7
VRQVVLKSKNGIHVF	CYP4Z1	486	Q86W10
VNLLFHKFKGTIILT	TMEM138	71	Q9NPI0
VIHLPFIIVNTSKKT	TFDP1	256	Q14186
HVEAIKIGLTKALTQ	ZWINT	106	O95229
KETNIQLFVGLKVHL	EEFSEC	496	P57772
AVGFKQTVHKLLIVV	PSMD3	321	O43242
KGVQHIFRVLSTTVK	SPEG	1351	Q15772
INGKLVKSIFRVVFH	TFCP2	111	Q12800
SKINHVLIEAKTIFV	THAP9	541	Q9H5L6
IVTNVRNTIHGFKKL	HSPA4L	56	O95757
SKVKVKVRVNIHGIF	HSPA4L	476	O95757
IKILGRFQILKTITH	TBCK	36	Q8TEA7
EVLHQIFSKFGTVLK	PTBP3	196	O95758
LRVHKTFKFVVVGVL	TNFRSF10A	86	O00220
LEKKAVAVGHSQVFL	MYO18B	1306	Q8IUG5
FGVKLGSQIFIKHIT	TJP3	206	O95049
AVHIVQFIFILKLGT	SLC30A5	56	Q8TAD4
EGVKLVVNKVLSSHF	TOMM40L	46	Q969M1
AKSSVKIHISKVIIG	ZNF818P	41	Q6ZRF7
VEHQRTTFVKQLKLG	USP30	301	Q70CQ3
VSIVVSGKIFKAHKN	ZBTB10	366	Q96DT7
QVVKLIGSHTISKVT	UBR4	3561	Q5T4S7
IVKKQFQSKIHSRIG	TIGD7	511	Q6NT04
HQIFSKFGTVLKIIT	PTBP1	201	P26599
FIIVNSITIKIHSKA	UHRF1BP1	126	Q6BDS2
QQGTFVAHKEIKLTL	ZC3H18	806	Q86VM9
TGLVHLVVVAAKKLV	KIAA2013	256	Q8IYS2
KEVKKHISIAAFTIQ	NAALAD2	716	Q9Y3Q0