Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	calcium ion binding	CAPN14 HSP90B1 ENPP3 ITSN1 ANXA8L1 LRP2 SDF4 ANXA8 FER1L5 LDLR	5.30e-05	749	58	10	GO:0005509
GeneOntologyMolecularFunction	fucose binding	ASGR1 CLEC10A	2.30e-04	8	58	2	GO:0042806
GeneOntologyMolecularFunction	low-density lipoprotein particle receptor activity	LRP2 LDLR	9.69e-04	16	58	2	GO:0005041
GeneOntologyMolecularFunction	magnesium ion transmembrane transporter activity	NIPA2 SLC41A1	1.23e-03	18	58	2	GO:0015095
GeneOntologyMolecularFunction	C-acyltransferase activity	ACSM3 GCAT	1.68e-03	21	58	2	GO:0016408
GeneOntologyMolecularFunction	lipoprotein particle receptor activity	LRP2 LDLR	1.68e-03	21	58	2	GO:0030228
GeneOntologyMolecularFunction	cargo receptor activity	ASGR1 LRP2 LDLR	1.94e-03	85	58	3	GO:0038024
GeneOntologyMolecularFunction	actin binding	EPS8 MYH7 FBXO25 ANXA8L1 ANXA8 MYO15A	2.60e-03	479	58	6	GO:0003779
GeneOntologyMolecularFunction	D-mannose binding	ASGR1 CLEC10A	2.78e-03	27	58	2	GO:0005537
GeneOntologyBiologicalProcess	negative regulation of phospholipase A2 activity	ANXA8L1 ANXA8	2.25e-05	3	57	2	GO:1900138
GeneOntologyBiologicalProcess	positive regulation of lysosomal protein catabolic process	LRP2 LDLR	7.46e-05	5	57	2	GO:1905167
GeneOntologyBiologicalProcess	negative regulation of phospholipase activity	ANXA8L1 ANXA8	7.46e-05	5	57	2	GO:0010519
GeneOntologyBiologicalProcess	positive regulation of protein catabolic process in the vacuole	LRP2 LDLR	1.56e-04	7	57	2	GO:1904352
GeneOntologyBiologicalProcess	peptide hormone processing	ACE2 HSP90B1 CTSL	1.98e-04	41	57	3	GO:0016486
GeneOntologyBiologicalProcess	negative regulation of serine-type peptidase activity	ANXA8L1 ANXA8	2.08e-04	8	57	2	GO:1902572
GeneOntologyBiologicalProcess	negative regulation of serine-type endopeptidase activity	ANXA8L1 ANXA8	2.08e-04	8	57	2	GO:1900004
GeneOntologyBiologicalProcess	signaling receptor ligand precursor processing	ACE2 HSP90B1 CTSL	2.79e-04	46	57	3	GO:0140448
GeneOntologyBiologicalProcess	receptor-mediated endocytosis	ACE2 ASGR1 ITSN1 LRP2 CTSL LDLR	3.27e-04	337	57	6	GO:0006898
GeneOntologyBiologicalProcess	regulation of serine-type peptidase activity	ANXA8L1 ANXA8	3.33e-04	10	57	2	GO:1902571
GeneOntologyBiologicalProcess	regulation of phospholipase A2 activity	ANXA8L1 ANXA8	3.33e-04	10	57	2	GO:0032429
GeneOntologyBiologicalProcess	regulation of serine-type endopeptidase activity	ANXA8L1 ANXA8	3.33e-04	10	57	2	GO:1900003
GeneOntologyCellularComponent	endosome	NDRG1 ITSN1 ANXA8L1 LRP2 SDF4 NIPA2 ANXA8 CACFD1 GPNMB CTSL LDLR	2.70e-04	1167	57	11	GO:0005768
GeneOntologyCellularComponent	cluster of actin-based cell projections	ACE2 EPS8 DDR1 LRP2 MYO15A	3.52e-04	223	57	5	GO:0098862
GeneOntologyCellularComponent	external side of plasma membrane	SPAM1 ASGR1 ENPP3 LRP2 CLEC10A CTSL LDLR	5.04e-04	519	57	7	GO:0009897
GeneOntologyCellularComponent	endoplasmic reticulum chaperone complex	HSP90B1 PDIA6	5.59e-04	13	57	2	GO:0034663
GeneOntologyCellularComponent	endocytic vesicle	ACE2 HSP90B1 ITSN1 LRP2 CTSL LDLR	6.08e-04	384	57	6	GO:0030139
GeneOntologyCellularComponent	brush border	ACE2 EPS8 DDR1 LRP2	7.87e-04	152	57	4	GO:0005903
GeneOntologyCellularComponent	clathrin-coated pit	ITSN1 LRP2 LDLR	1.36e-03	80	57	3	GO:0005905
HumanPheno	Talipes cavus equinovarus	MYH7 NDRG1	8.75e-05	4	20	2	HP:0004696
HumanPheno	Elevated jugular venous pressure	BMP6 MYH7	8.75e-05	4	20	2	HP:0030848
HumanPheno	Abnormal jugular venous pressure	BMP6 MYH7	8.75e-05	4	20	2	HP:0030847
Domain	AnnexinVIII	ANXA8L1 ANXA8	9.15e-06	2	57	2	IPR009115
Domain	Lectin_N	ASGR1 CLEC10A	2.74e-05	3	57	2	PF03954
Domain	Lectin_N	ASGR1 CLEC10A	2.74e-05	3	57	2	IPR005640
Domain	E-NPP	ENPP6 ENPP3	1.90e-04	7	57	2	IPR024873
Domain	Phosphodiest	ENPP6 ENPP3	4.05e-04	10	57	2	PF01663
Domain	Phosphodiest/P_Trfase	ENPP6 ENPP3	4.05e-04	10	57	2	IPR002591
Domain	ANX	ANXA8L1 ANXA8	6.99e-04	13	57	2	SM00335
Domain	ANNEXIN	ANXA8L1 ANXA8	6.99e-04	13	57	2	PS00223
Domain	Annexin_repeat_CS	ANXA8L1 ANXA8	6.99e-04	13	57	2	IPR018252
Domain	Annexin	ANXA8L1 ANXA8	6.99e-04	13	57	2	PF00191
Domain	Annexin_repeat	ANXA8L1 ANXA8	6.99e-04	13	57	2	IPR018502
Domain	-	ANXA8L1 ANXA8	6.99e-04	13	57	2	1.10.220.10
Domain	Annexin	ANXA8L1 ANXA8	8.13e-04	14	57	2	IPR001464
Domain	Ldl_recept_b	LRP2 LDLR	8.13e-04	14	57	2	PF00058
Domain	LDLRB	LRP2 LDLR	8.13e-04	14	57	2	PS51120
Domain	LY	LRP2 LDLR	9.37e-04	15	57	2	SM00135
Domain	LDLR_classB_rpt	LRP2 LDLR	9.37e-04	15	57	2	IPR000033
Domain	FA58C	DDR1 DCBLD2	1.85e-03	21	57	2	SM00231
Domain	FA58C_3	DDR1 DCBLD2	1.85e-03	21	57	2	PS50022
Domain	FA58C_1	DDR1 DCBLD2	1.85e-03	21	57	2	PS01285
Domain	FA58C_2	DDR1 DCBLD2	1.85e-03	21	57	2	PS01286
Domain	F5_F8_type_C	DDR1 DCBLD2	2.42e-03	24	57	2	PF00754
Domain	FA58C	DDR1 DCBLD2	2.42e-03	24	57	2	IPR000421
Domain	THIOL_PROTEASE_CYS	CAPN14 CTSL	2.84e-03	26	57	2	PS00139
Domain	THIOL_PROTEASE_ASN	CAPN14 CTSL	3.06e-03	27	57	2	PS00640
Domain	THIOL_PROTEASE_HIS	CAPN14 CTSL	3.06e-03	27	57	2	PS00639
Domain	Pept_cys_AS	CAPN14 CTSL	3.29e-03	28	57	2	IPR000169
Domain	Alkaline_phosphatase_core	ENPP6 ENPP3	4.02e-03	31	57	2	IPR017850
Domain	Alkaline_Pase-like_a/b/a	ENPP6 ENPP3	4.02e-03	31	57	2	IPR017849
Domain	-	ENPP6 ENPP3	4.02e-03	31	57	2	3.40.720.10
Domain	Myosin_head_motor_dom	MYH7 MYO15A	6.00e-03	38	57	2	IPR001609
Domain	MYOSIN_MOTOR	MYH7 MYO15A	6.00e-03	38	57	2	PS51456
Domain	Myosin_head	MYH7 MYO15A	6.00e-03	38	57	2	PF00063
Domain	MYSc	MYH7 MYO15A	6.00e-03	38	57	2	SM00242
Domain	-	LRP2 LDLR	6.31e-03	39	57	2	2.120.10.30
Domain	LDLR_class-A_CS	LRP2 LDLR	6.63e-03	40	57	2	IPR023415
Domain	C-type_lectin_CS	ASGR1 CLEC10A	7.63e-03	43	57	2	IPR018378
Domain	Ldl_recept_a	LRP2 LDLR	8.33e-03	45	57	2	PF00057
Domain	-	LRP2 LDLR	8.69e-03	46	57	2	4.10.400.10
Domain	6-blade_b-propeller_TolB-like	LRP2 LDLR	8.69e-03	46	57	2	IPR011042
Domain	ER_TARGET	HSP90B1 PDIA6	9.06e-03	47	57	2	PS00014
Domain	LDLRA_1	LRP2 LDLR	9.43e-03	48	57	2	PS01209
Pubmed	SARS-CoV-2 exacerbates proinflammatory responses in myeloid cells through C-type lectin receptors and Tweety family member 2.	ACE2 ASGR1 CLEC10A	1.70e-07	7	60	3	34048708
Pubmed	Identification of lectin receptors for conserved SARS-CoV-2 glycosylation sites.	ACE2 ASGR1 CLEC10A	2.72e-07	8	60	3	34375000
Pubmed	TaqI polymorphisms at the annexin VIII locus (ANX8).	ANXA8L1 ANXA8	2.93e-06	2	60	2	1364010
Pubmed	Annexin A8 controls leukocyte recruitment to activated endothelial cells via cell surface delivery of CD63.	ANXA8L1 ANXA8	2.93e-06	2	60	2	24769558
Pubmed	Discoidin domain receptor 1 (ddr1) deletion decreases atherosclerosis by accelerating matrix accumulation and reducing inflammation in low-density lipoprotein receptor-deficient mice.	DDR1 LDLR	2.93e-06	2	60	2	18451340
Pubmed	Cooperative binding promotes demand-driven recruitment of AnxA8 to cholesterol-containing membranes.	ANXA8L1 ANXA8	2.93e-06	2	60	2	29306076
Pubmed	Angiotensin-converting enzyme 2 decreases formation and severity of angiotensin II-induced abdominal aortic aneurysms.	ACE2 LDLR	2.93e-06	2	60	2	25301841
Pubmed	Angiotensin-converting enzyme 2 deficiency in whole body or bone marrow-derived cells increases atherosclerosis in low-density lipoprotein receptor-/- mice.	ACE2 LDLR	2.93e-06	2	60	2	21252069
Pubmed	Discoidin domain receptor 1 on bone marrow-derived cells promotes macrophage accumulation during atherogenesis.	DDR1 LDLR	2.93e-06	2	60	2	19834008
Pubmed	Bone matrix regulates osteoclast differentiation and annexin A8 gene expression.	ANXA8L1 ANXA8	2.93e-06	2	60	2	21344395
Pubmed	Annexin A8 is up-regulated during mouse mammary gland involution and predicts poor survival in breast cancer.	ANXA8L1 ANXA8	2.93e-06	2	60	2	16203777
Pubmed	Annexins: linking Ca2+ signalling to membrane dynamics.	ANXA8L1 ANXA8	2.93e-06	2	60	2	15928709
Pubmed	Increased cell and matrix accumulation during atherogenesis in mice with vessel wall-specific deletion of discoidin domain receptor 1.	DDR1 LDLR	2.93e-06	2	60	2	20448217
Pubmed	Annexins: from structure to function.	ANXA8L1 ANXA8	2.93e-06	2	60	2	11917092
Pubmed	Asialoglycoprotein receptor 1 promotes SARS-CoV-2 infection of human normal hepatocytes.	ACE2 ASGR1	2.93e-06	2	60	2	38355848
Pubmed	Discoidin domain receptor-1 deficiency attenuates atherosclerotic calcification and smooth muscle cell-mediated mineralization.	DDR1 LDLR	2.93e-06	2	60	2	19893047
Pubmed	Discoidin domain receptor 1-deletion ameliorates fibrosis and promotes adipose tissue beiging, brown fat activity, and increased metabolic rate in a mouse model of cardiometabolic disease.	DDR1 LDLR	2.93e-06	2	60	2	32360427
Pubmed	Annexin A8 identifies a subpopulation of transiently quiescent c-kit positive luminal progenitor cells of the ductal mammary epithelium.	ANXA8L1 ANXA8	2.93e-06	2	60	2	25803307
Pubmed	Cathepsin L plays a key role in SARS-CoV-2 infection in humans and humanized mice and is a promising target for new drug development.	ACE2 CTSL	2.93e-06	2	60	2	33774649
Pubmed	Circulating FABP4 is eliminated by the kidney via glomerular filtration followed by megalin-mediated reabsorption.	NDRG1 LRP2	8.77e-06	3	60	2	30401801
Pubmed	Specific expression of annexin A8 in adult murine stratified epithelia.	ANXA8L1 ANXA8	8.77e-06	3	60	2	17082908
Pubmed	Discoidin Domain Receptor-1 Regulates Calcific Extracellular Vesicle Release in Vascular Smooth Muscle Cell Fibrocalcific Response via Transforming Growth Factor-β Signaling.	DDR1 LDLR	8.77e-06	3	60	2	26800565
Pubmed	Modulation of blood cell gene expression by DHA supplementation in hypertriglyceridemic men.	CTSL LDLR	8.77e-06	3	60	2	21775114
Pubmed	A novel role for the macrophage galactose-type lectin receptor in mediating von Willebrand factor clearance.	ASGR1 CLEC10A	8.77e-06	3	60	2	29282218
Pubmed	Asialoglycoprotein receptor deficiency in mice lacking the minor receptor subunit.	ASGR1 LDLR	8.77e-06	3	60	2	7961705
Pubmed	Phase separation-mediated condensation of Whirlin-Myo15-Eps8 stereocilia tip complex.	EPS8 MYO15A	8.77e-06	3	60	2	33626355
Pubmed	Cathepsin L deficiency reduces diet-induced atherosclerosis in low-density lipoprotein receptor-knockout mice.	CTSL LDLR	8.77e-06	3	60	2	17404153
Pubmed	Diabetic Vascular Calcification Mediated by the Collagen Receptor Discoidin Domain Receptor 1 via the Phosphoinositide 3-Kinase/Akt/Runt-Related Transcription Factor 2 Signaling Axis.	DDR1 LDLR	8.77e-06	3	60	2	29930002
Pubmed	Angiotensinogen and Megalin Interactions Contribute to Atherosclerosis-Brief Report.	LRP2 LDLR	8.77e-06	3	60	2	30567480
Pubmed	Clec10a regulates mite-induced dermatitis.	ASGR1 CLEC10A	8.77e-06	3	60	2	31811054
Pubmed	Novel myosin mutations for hereditary hearing loss revealed by targeted genomic capture and massively parallel sequencing.	MYH7 MYO15A	8.77e-06	3	60	2	24105371
Pubmed	Vascular anticoagulant beta: a novel human Ca2+/phospholipid binding protein that inhibits coagulation and phospholipase A2 activity. Its molecular cloning, expression and comparison with VAC-alpha.	ANXA8L1 ANXA8	8.77e-06	3	60	2	2530088
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	HSP90B1 DMXL2 NDRG1 GRHPR ITSN1 YLPM1 LRP2 ZNF624 ZNF606 CTSL PBXIP1	1.09e-05	1285	60	11	35914814
Pubmed	Proteomic analysis of early melanosomes: identification of novel melanosomal proteins.	HSP90B1 PDIA6 GPNMB	1.73e-05	29	60	3	12643545
Pubmed	Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoV.	ACE2 CTSL	1.75e-05	4	60	2	32221306
Pubmed	AXL is a candidate receptor for SARS-CoV-2 that promotes infection of pulmonary and bronchial epithelial cells.	ACE2 LDLR	1.75e-05	4	60	2	33420426
Pubmed	Regulation of stereocilia length by myosin XVa and whirlin depends on the actin-regulatory protein Eps8.	EPS8 MYO15A	1.75e-05	4	60	2	21236676
Pubmed	Female reproductive tract has low concentration of SARS-CoV2 receptors.	ACE2 CTSL	1.75e-05	4	60	2	33315943
Pubmed	Urinary FABP1 is a biomarker for impaired proximal tubular protein reabsorption and is synergistically enhanced by concurrent liver injury.	NDRG1 LRP2	1.75e-05	4	60	2	34370295
Pubmed	Asialoglycoprotein receptor 1 is a novel PCSK9-independent ligand of liver LDLR cleaved by furin.	ASGR1 LDLR	1.75e-05	4	60	2	34508778
Pubmed	GRP94 Regulates Circulating Cholesterol Levels through Blockade of PCSK9-Induced LDLR Degradation.	HSP90B1 LDLR	1.75e-05	4	60	2	26628375
Pubmed	SARS-CoV-2 Spike Protein Interacts with Multiple Innate Immune Receptors.	ACE2 CLEC10A	2.92e-05	5	60	2	32766577
Pubmed	Retention of mutant low density lipoprotein receptor in endoplasmic reticulum (ER) leads to ER stress.	HSP90B1 LDLR	2.92e-05	5	60	2	16257961
Pubmed	Interaction of coagulation factor VIII with members of the low-density lipoprotein receptor family follows common mechanism and involves consensus residues within the A2 binding site 484-509.	LRP2 LDLR	2.92e-05	5	60	2	18685438
Pubmed	Phosphorylation-dependent interaction of the asialoglycoprotein receptor with molecular chaperones.	HSP90B1 ASGR1	4.37e-05	6	60	2	12167617
Pubmed	Increase of Total Nephron Albumin Filtration and Reabsorption in Diabetic Nephropathy.	NDRG1 LRP2	4.37e-05	6	60	2	27382987
Pubmed	Interaction of cytosolic adaptor proteins with neuronal apolipoprotein E receptors and the amyloid precursor protein.	LRP2 LDLR	4.37e-05	6	60	2	9837937
Pubmed	The PX-domain protein SNX17 interacts with members of the LDL receptor family and modulates endocytosis of the LDL receptor.	LRP2 LDLR	6.11e-05	7	60	2	12169628
Pubmed	The genetic origin of mouse annexin VIII.	ANXA8L1 ANXA8	6.11e-05	7	60	2	9434938
Pubmed	Ca2+ entry through mechanotransduction channels localizes BAIAP2L2 to stereocilia tips.	EPS8 MYO15A	8.14e-05	8	60	2	35044843
Pubmed	GRP78/BiP is required for cell proliferation and protecting the inner cell mass from apoptosis during early mouse embryonic development.	HSP90B1 PDIA6	1.05e-04	9	60	2	16847323
Pubmed	GPSM2-GNAI Specifies the Tallest Stereocilia and Defines Hair Bundle Row Identity.	EPS8 MYO15A	1.05e-04	9	60	2	30827920
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	ACE2 NRDE2 DMXL2 PDIA6 POLRMT TIMM29 PBXIP1	1.26e-04	650	60	7	38777146
Pubmed	NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals.	CTSL LDLR	1.31e-04	10	60	2	20428172
Pubmed	FAM105A/OTULINL Is a Pseudodeubiquitinase of the OTU-Class that Localizes to the ER Membrane.	HSP90B1 PDIA6 BSDC1 SDF4 LYSMD3 PBXIP1	1.56e-04	468	60	6	31056421
Pubmed	Structural characterization and chromosomal location of the mouse macrophage migration inhibitory factor gene and pseudogenes.	DDR1 LDLR	1.59e-04	11	60	2	7558021
Pubmed	CIB2 interacts with TMC1 and TMC2 and is essential for mechanotransduction in auditory hair cells.	EPS8 MYO15A	1.91e-04	12	60	2	28663585
Pubmed	Receptome profiling identifies KREMEN1 and ASGR1 as alternative functional receptors of SARS-CoV-2.	ACE2 ASGR1	1.91e-04	12	60	2	34837059
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	BMP6 HSP90B1 PDIA6 SDF4 LYSMD3 CTSL DCBLD2 LDLR PBXIP1	2.05e-04	1201	60	9	35696571
Pubmed	HIV-host interactome revealed directly from infected cells.	HSP90B1 PDIA6 ERAP2 PBXIP1	2.27e-04	172	60	4	27375898
Pubmed	Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers.	ENPP6 CAPN14 DMXL2 ACSM3 LRP2 LDLR GRK1	2.57e-04	730	60	7	34857952
Pubmed	Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry.	HSP90B1 CTSL LDLR	2.57e-04	71	60	3	12754519
Pubmed	A subset of chaperones and folding enzymes form multiprotein complexes in endoplasmic reticulum to bind nascent proteins.	HSP90B1 PDIA6	2.63e-04	14	60	2	12475965
Pubmed	Functional domains of the FgfrL1 receptor.	MYH7 LRP2	2.63e-04	14	60	2	31923383
Pubmed	Stage-specific association of apolipoprotein A-I and E in developing mouse retina.	LRP2 LDLR	2.63e-04	14	60	2	17389516
Pubmed	Normal development and fertility of knockout mice lacking the tumor suppressor gene LRP1b suggest functional compensation by LRP1.	HSP90B1 LRP2	2.63e-04	14	60	2	15082773
Pubmed	RGS12 polarizes the GPSM2-GNAI complex to organize and elongate stereocilia in sensory hair cells.	EPS8 MYO15A	3.03e-04	15	60	2	36260679
Pubmed	Evolutionary trajectory of receptor binding specificity and promiscuity of the spike protein of SARS-CoV-2.	ACE2 LYSMD3	3.03e-04	15	60	2	36305765
Pubmed	Large-scale proteomics and phosphoproteomics of urinary exosomes.	ENPP6 ACE2 EPS8 NDRG1 GRHPR ENPP3 LRP2 MYO15A	3.44e-04	1016	60	8	19056867
Pubmed	Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes.	HSP90B1 PDIA6 GPNMB	3.52e-04	79	60	3	17081065
Pubmed	Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction.	LRP2 LDLR	4.40e-04	18	60	2	10827173
Pubmed	Marked differences between metalloproteases meprin A and B in substrate and peptide bond specificity.	SCT CTSL	4.40e-04	18	60	2	11278902
Pubmed	Mapping of functional SARS-CoV-2 receptors in human lungs establishes differences in variant binding and SLC1A5 as a viral entry modulator of hACE2.	ACE2 HSP90B1 PDIA6	5.85e-04	94	60	3	36584595
Pubmed	Differential gene expression in the distal tip endoderm of the embryonic mouse lung.	HSP90B1 PDIA6	6.02e-04	21	60	2	12617806
Pubmed	MESD is essential for apical localization of megalin/LRP2 in the visceral endoderm.	LRP2 LDLR	6.02e-04	21	60	2	21337463
Pubmed	Genetic loci controlling body fat, lipoprotein metabolism, and insulin levels in a multifactorial mouse model.	LRP2 LDLR	6.02e-04	21	60	2	9616220
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	ENPP6 SPAM1 GCAT BAZ2A POLRMT LRP2 SDF4 LDLR	6.39e-04	1116	60	8	31753913
Pubmed	Glucocorticoid receptor is required for foetal heart maturation.	MYH7 HSD11B2	6.61e-04	22	60	2	23595884
Pubmed	Candidate downstream regulated genes of HOX group 13 transcription factors with and without monomeric DNA binding capability.	ANXA8L1 ANXA8	6.61e-04	22	60	2	15733672
Pubmed	DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation.	MYH7 ITSN1	6.61e-04	22	60	2	12812986
Pubmed	Mapping wild-type and R345W fibulin-3 intracellular interactomes.	HSP90B1 PDIA6	6.61e-04	22	60	2	27777122
Pubmed	Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins.	DDR1 LRP2 LDLR	7.21e-04	101	60	3	23382219
Pubmed	Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).	DDR1 HSP90B1 ENPP3 SDF4 TMPRSS11B	7.69e-04	417	60	5	19199708
Pubmed	CRISPR activation screen identifies BCL-2 proteins and B3GNT2 as drivers of cancer resistance to T cell-mediated cytotoxicity.	HSP90B1 PDIA6 LRP2 SDF4 PBXIP1	7.77e-04	418	60	5	35338135
Pubmed	CDNF and MANF regulate ER stress in a tissue-specific manner.	HSP90B1 PDIA6	7.88e-04	24	60	2	35129674
Pubmed	Modulation of cytokine release and gene expression by the immunosuppressive domain of gp41 of HIV-1.	ASGR1 GPNMB CLEC10A	8.76e-04	108	60	3	23383108
Pubmed	Intersectin (ITSN) family of scaffolds function as molecular hubs in protein interaction networks.	ITSN1 YLPM1 GPNMB	9.48e-04	111	60	3	22558309
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	HSP90B1 DMXL2 PDIA6 ERAP2 BAZ2A ITSN1 POLRMT SDF4 PBXIP1	9.64e-04	1487	60	9	33957083
Pubmed	Osteocyte transcriptome mapping identifies a molecular landscape controlling skeletal homeostasis and susceptibility to skeletal disease.	ANXA8L1 ANXA8	1.07e-03	28	60	2	33953184
Pubmed	Endoplasmic reticulum resident protein 44 (ERp44) deficiency in mice and zebrafish leads to cardiac developmental and functional defects.	HSP90B1 PDIA6	1.07e-03	28	60	2	25332179
Pubmed	FCH domain only-2 organizes clathrin-coated structures and interacts with Disabled-2 for low-density lipoprotein receptor endocytosis.	YLPM1 LDLR	1.32e-03	31	60	2	22323290
Pubmed	Hepatic lipase maturation: a partial proteome of interacting factors.	HSP90B1 PDIA6	1.32e-03	31	60	2	19136429
Pubmed	Pharmacogenetic predictors of statin-mediated low-density lipoprotein cholesterol reduction and dose response.	LRP2 LDLR	1.32e-03	31	60	2	20031551
Pubmed	Activation of Notch1 signaling in cardiogenic mesoderm induces abnormal heart morphogenesis in mouse.	BMP6 MYH7	1.32e-03	31	60	2	16554359
Pubmed	The NANCI-Nkx2.1 gene duplex buffers Nkx2.1 expression to maintain lung development and homeostasis.	ANXA8L1 ANXA8	1.40e-03	32	60	2	28546511
Pubmed	Mitochondrial Raf1 Regulates Glutamine Catabolism.	HSP90B1 PDIA6 NDRG1 GPNMB	1.56e-03	288	60	4	38496616
Interaction	TG interactions	HSP90B1 ASGR1 LRP2 CTSL	6.49e-08	14	59	4	int:TG
Interaction	PDIA4 interactions	ACE2 HSP90B1 PDIA6 ERAP2 PXMP2 LRP2 SDF4 CTSL LDLR TMPRSS11B	9.40e-07	468	59	10	int:PDIA4
Interaction	ANXA8L1 interactions	HSP90B1 ANXA8L1 ANXA8	5.15e-06	12	59	3	int:ANXA8L1
Interaction	FAF2 interactions	ACE2 HSP90B1 DMXL2 GCAT PXMP2 TIMM29 CTSL TMPRSS11B	4.82e-05	451	59	8	int:FAF2
Interaction	DAB2 interactions	ACE2 ITSN1 YLPM1 LRP2 LDLR	5.58e-05	140	59	5	int:DAB2
Interaction	DNAJB11 interactions	ACE2 HSP90B1 PDIA6 ERAP2 ITSN1 CTSL TMPRSS11B	7.18e-05	351	59	7	int:DNAJB11
Cytoband	10q11.22	ANXA8L1 ANXA8	1.33e-03	41	60	2	10q11.22
GeneFamily	Low density lipoprotein receptors	LRP2 LDLR	2.97e-04	13	36	2	634
GeneFamily	Annexins\|Endogenous ligands	ANXA8L1 ANXA8	2.97e-04	13	36	2	404
GeneFamily	C-type lectin domain family	ASGR1 CLEC10A	3.94e-03	47	36	2	494
Coexpression	GSE19401_PAM2CSK4_VS_RETINOIC_ACID_AND_PAM2CSK4_STIM_FOLLICULAR_DC_DN	HSP90B1 PDIA6 ACSM3 GPNMB CLEC10A CTSL	6.51e-06	200	60	6	M7668
Coexpression	SHAFFER_IRF4_TARGETS_IN_PLASMA_CELL_VS_MATURE_B_LYMPHOCYTE	BMP6 HSP90B1 NDRG1 LDLR	1.71e-05	67	60	4	M12037
ToppCell	droplet-Spleen-nan-3m-Myeloid-macrophage_dendritic_cell_progenitor\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DDR1 SCT ROBO3 CLEC10A CTSL	3.86e-06	175	60	5	21bc0e59a9509d38751ce6aad2325f341bc70eff
ToppCell	facs-Marrow-T_cells-18m-Myeloid-CD4+_macrophage\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DDR1 ITSN1 SCT CLEC10A CTSL	3.97e-06	176	60	5	74f851a398c7562dd713bc0d8d488c0037243112
ToppCell	facs-Marrow-T_cells-18m-Myeloid-macrophage\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DDR1 ITSN1 SCT CLEC10A CTSL	3.97e-06	176	60	5	31b5459a978d5cdde0af03a77401e0464d8c95ba
ToppCell	droplet-Spleen-SPLEEN-1m-Myeloid-macrophage_dendritic_cell_progenitor\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DDR1 SCT ROBO3 CLEC10A CTSL	4.20e-06	178	60	5	742ee0cb8cb585a5e34bd5b20aebe9bb99756e0c
ToppCell	droplet-Marrow-nan-3m-Lymphocytic\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DDR1 HSP90B1 ROBO3 CLEC10A CTSL	4.31e-06	179	60	5	dcaf2191134a586d50ebaf67dcf5b815b54a722b
ToppCell	droplet-Marrow-nan-3m-Lymphocytic-nan\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DDR1 HSP90B1 ROBO3 CLEC10A CTSL	4.31e-06	179	60	5	87a69f9f83b8f0c028a4874acb238f2e079bf51f
ToppCell	10x5'-GI_large-bowel-Myeloid_Monocytic\|GI_large-bowel / Manually curated celltypes from each tissue	DMXL2 ASGR1 GPNMB CLEC10A CTSL	5.47e-06	188	60	5	d0045fdda757d191dabc7853f6a6e99c0e97d93d
ToppCell	10x5'-GI_large-bowel-Myeloid_Monocytic-Classical_monocytes\|GI_large-bowel / Manually curated celltypes from each tissue	DMXL2 ASGR1 GPNMB CLEC10A CTSL	5.47e-06	188	60	5	0bcf04aa47738f43c1a87dae5dc487738ee86f8c
ToppCell	Smart-seq2-lymph_node_(Smart-seq2)-myeloid\|lymph_node_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	DMXL2 ASGR1 ENPP3 CLEC10A LDLR	5.62e-06	189	60	5	2aebea7a6c2f83112d7c504b742f2c04b92e459a
ToppCell	(6)_Macrophage\|World / shred on Cell_type and subtype	DMXL2 ASGR1 GPNMB CLEC10A CTSL	6.87e-06	197	60	5	010b275d4da4a896175ad7fbaa96d1dc11a0b744
ToppCell	medial-Hematologic-Interstitial_Macrophage-2\|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	DMXL2 ASGR1 GPNMB CLEC10A CTSL	6.87e-06	197	60	5	b90c8a41e99c87b46be699d03cd49c97a2ad51af
ToppCell	medial-Hematologic-Interstitial_Macrophage\|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	DMXL2 ASGR1 GPNMB CLEC10A CTSL	6.87e-06	197	60	5	13aec816e21754eac590a12c3a9c795c41108277
ToppCell	medial-2-Hematologic-Interstitial_Macrophage\|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	DMXL2 ASGR1 GPNMB CLEC10A CTSL	6.87e-06	197	60	5	38a74eeb2a4c8d6a86b133f02f4e6c641f16a3ac
ToppCell	Monocytes-Phagocytic_CD16+_macrophages\|World / Immune cells in Kidney/Urine in Lupus Nephritis	DMXL2 ASGR1 ITSN1 GPNMB CTSL	7.04e-06	198	60	5	09009cc966bf1503c3b15dfa079a6c5f6ad1f507
ToppCell	10x_3'_v3-thymus_(10x_3'_v3)-myeloid-myeloid_macrophage\|thymus_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	DMXL2 ITSN1 GPNMB CLEC10A CTSL	7.22e-06	199	60	5	b827dd8a249f904a0ff930a6c4d3b00fb7bc6fb1
ToppCell	10x_3'_v3-thymus_(10x_3'_v3)-myeloid-myeloid_macrophage-macrophage\|thymus_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	DMXL2 ITSN1 GPNMB CLEC10A CTSL	7.22e-06	199	60	5	c0dcdda30485bb920d3706dcfb06f11b76b6ea37
ToppCell	Sigmoid-(6)_Macrophage-(61)_LYVE1_Macrophage\|Sigmoid / shred on region, Cell_type, and subtype	EPS8 DMXL2 GPNMB CLEC10A CTSL	7.39e-06	200	60	5	bc0280d52e4edc2c5edf4ead164a1c7cf3fccd60
ToppCell	mLN-(6)_Macrophage-(61)_LYVE1_Macrophage\|mLN / shred on region, Cell_type, and subtype	DMXL2 ASGR1 ITSN1 GPNMB CLEC10A	7.39e-06	200	60	5	a20f5ec61d492d8a2adf695ec304b5d57296aa8f
ToppCell	mLN-Macrophage-LYVE1_Macrophage\|mLN / Region, Cell class and subclass	DMXL2 ASGR1 ITSN1 GPNMB CLEC10A	7.39e-06	200	60	5	89cf739a3c2f5d30e547404f2f2ec6500cd1d65d
ToppCell	Sigmoid-Macrophage-LYVE1_Macrophage\|Sigmoid / Region, Cell class and subclass	EPS8 DMXL2 GPNMB CLEC10A CTSL	7.39e-06	200	60	5	851a1b372ddbec522829069e69ed36a1f4832131
ToppCell	normal_Pleural_Fluid-Myeloid_cells-Pleural_Mac\|Myeloid_cells / Location, Cell class and cell subclass	HSP90B1 DMXL2 PDIA6 CLEC10A CTSL	7.39e-06	200	60	5	bffebc281a5c1c2bfdb2696a45343787289fc374
ToppCell	(61)_LYVE1_Macrophage\|World / shred on Cell_type and subtype	DMXL2 ASGR1 GPNMB CLEC10A CTSL	8.53e-06	206	60	5	711e961a9a03bfd2f0958bd14f25f7f207a2f2b5
ToppCell	droplet-Liver-hepatocytes-3m-Epithelial-Hepatocyte_(Midlobular)\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GRHPR GCAT ASGR1 PXMP2	5.41e-05	153	60	4	d9e2c386875bc15e1e6e75dc7acf05c0dc8c306b
ToppCell	BAL-Severe-cDC_4\|Severe / Compartment, Disease Groups and Clusters	ACSM3 ASGR1 ZNF624 CLEC10A	6.13e-05	158	60	4	73f66689ef59f71b14cb7141ca5951cc47fe57c1
ToppCell	facs-Brain_Myeloid-Cerebellum-3m-Myeloid-macrophage\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPS8 DDR1 CLEC10A LDLR	6.28e-05	159	60	4	323cb4a2416d2e6bff0a3f225d2edeae9ab7dc76
ToppCell	droplet-Kidney-KIDNEY-30m-Epithelial-nan\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACSM3 NDRG1 GRHPR LRP2	6.28e-05	159	60	4	c34a7d227dbda2d7c76f937e1a58552b14bd40b5
ToppCell	PND07-Endothelial-Endothelial_lymphatic\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	NDRG1 ENPP3 ROBO3 SLC41A1	6.59e-05	161	60	4	133b4fadb499e842c19f573f9cf09ce08c1d4813
ToppCell	356C-Epithelial_cells-Epithelial-C_(AT2)-\|356C / Donor, Lineage, Cell class and subclass (all cells)	GCAT SP6 HSD11B2 DCBLD2	6.59e-05	161	60	4	78cb72c462167021195917a06052bcdc367ad890
ToppCell	PND07-Endothelial-Endothelial_lymphatic-Lymphatic_EC\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	NDRG1 ENPP3 ROBO3 SLC41A1	6.59e-05	161	60	4	9466b8658244116f8d21f2f88fb8c2d184b1bdf2
ToppCell	PND07-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	NDRG1 ENPP3 ROBO3 SLC41A1	6.59e-05	161	60	4	cb177ca10d848d0e25399ab5ebfcde1071fb94c2
ToppCell	356C-Epithelial_cells-Epithelial-C_(AT2)\|356C / Donor, Lineage, Cell class and subclass (all cells)	GCAT SP6 HSD11B2 DCBLD2	6.59e-05	161	60	4	06e7becfd11d6ef1a45a9cfdfcb40b812600038e
ToppCell	PND07-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_mature\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	NDRG1 ENPP3 ROBO3 SLC41A1	6.75e-05	162	60	4	96c6e94a10b124a1d25dcd705ec5aaa8609c1089
ToppCell	Globus_pallidus-Endothelial-ENDOTHELIAL_TIP-Dcn_1\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	SLC2A10 BMP6 ASGR1 ENPP3	7.25e-05	165	60	4	570483b43ccb5831feec9337b4664814431d40b1
ToppCell	Globus_pallidus-Endothelial-ENDOTHELIAL_TIP\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	SLC2A10 BMP6 ASGR1 ENPP3	7.25e-05	165	60	4	2026a9a07f4d314cc05c167e491312b373468e46
ToppCell	BAL-Mild-Myeloid-MoAM-MoAM5-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	DDR1 SP6 CLEC10A TMPRSS11B	7.42e-05	166	60	4	006ced12f69ef13ddcba5a3891ddc7c18c384863
ToppCell	BAL-Mild-Myeloid-MoAM-MoAM5\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	DDR1 SP6 CLEC10A TMPRSS11B	7.42e-05	166	60	4	ac28c8cac1e94be0c47fb862c5809c92cdaa11f3
ToppCell	BAL-Mild-Myeloid-MoAM-MoAM5-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	DDR1 SP6 CLEC10A TMPRSS11B	7.42e-05	166	60	4	6bb3410e65c971acc458c472015afcec6de6e310
ToppCell	droplet-Kidney-KIDNEY-30m-Epithelial-epithelial_cell_of_proximal_tubule\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACSM3 NDRG1 GRHPR LRP2	7.42e-05	166	60	4	0868f45d8d39ad39b5cee5e81ac3dd4dc512775d
ToppCell	BAL-Mild-Myeloid-MoAM-MoAM5\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	DDR1 SP6 CLEC10A TMPRSS11B	7.42e-05	166	60	4	823ec03714884cb860a1260410feac8c536b6d06
ToppCell	droplet-Spleen-nan-21m-Myeloid-macrophage_dendritic_cell_progenitor\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DDR1 ROBO3 CLEC10A CTSL	7.95e-05	169	60	4	7962165cab84af73d20b56eb70b1ed87c94025ef
ToppCell	facs-Marrow-T-cells-3m-Myeloid-CD4+_macrophage\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DDR1 ROBO3 CLEC10A CTSL	8.32e-05	171	60	4	6a0fafb8fd9fc7671618eeb2bf528ce8ce86b794
ToppCell	droplet-Spleen-nan-18m-Myeloid-macrophage_dendritic_cell_progenitor\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DDR1 ROBO3 CLEC10A CTSL	8.32e-05	171	60	4	4e856441063e9825b6f87a1d3dd19c77dae4662c
ToppCell	droplet-Lung-21m-Hematologic-myeloid-plasmacytoid_dendritic_cell-plasmacytoid_dendritic\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	DDR1 SCT ROBO3 CLEC10A	8.32e-05	171	60	4	2dfed6e9ac89adb2501a1a5e1ca895f49190562d
ToppCell	facs-Marrow-T-cells-3m-Myeloid-macrophage\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DDR1 ROBO3 CLEC10A CTSL	8.32e-05	171	60	4	e02b5831768dbb1b68998b672e55c9680ab0cc86
ToppCell	droplet-Lung-21m-Hematologic-myeloid-plasmacytoid_dendritic_cell\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	DDR1 SCT ROBO3 CLEC10A	8.32e-05	171	60	4	2aaae0229c3a13d0275a03a3d576db650c2bf2c0
ToppCell	droplet-Spleen-SPLEEN-30m-Myeloid-macrophage_dendritic_cell_progenitor\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DDR1 ROBO3 CLEC10A CTSL	8.51e-05	172	60	4	30916a902c151907745756d14327e24adc34afef
ToppCell	facs-Marrow-T-cells-24m-Myeloid-CD4+_macrophage\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DDR1 ROBO3 CLEC10A CTSL	8.70e-05	173	60	4	ca3d2a9562734f76127e3e7d54c10b63e95141bb
ToppCell	droplet-Lung-nan-21m-Myeloid-Plasmacytoid_Dendritic\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DDR1 SCT ROBO3 CLEC10A	8.70e-05	173	60	4	8fb32a9f2dbec16de840d55b4db7e7718f5a2a7a
ToppCell	facs-Marrow-T-cells-24m-Myeloid-macrophage\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DDR1 ROBO3 CLEC10A CTSL	8.70e-05	173	60	4	19a9e10885173d7712996be8660a3a5a7a9aa39f
ToppCell	droplet-Lung-nan-21m-Myeloid-plasmacytoid_dendritic_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DDR1 SCT ROBO3 CLEC10A	8.70e-05	173	60	4	f663571aaae2365660a8b526c355f4bd1a124a74
ToppCell	10x5'-bone_marrow-Myeloid_Mac-Intestinal_macrophages\|bone_marrow / Manually curated celltypes from each tissue	GPNMB CLEC10A METTL27 CTSL	8.90e-05	174	60	4	0746344d62aa7ab77c378e9d5a9f9238e741a76b
ToppCell	droplet-Marrow-BM-30m-Lymphocytic-precursor_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DDR1 ROBO3 CLEC10A CTSL	9.30e-05	176	60	4	d4075796c38b775fe721abb47426e662a0d415e3
ToppCell	PND14-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_prolif\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	EPS8 DMXL2 GCAT GPNMB	9.30e-05	176	60	4	450c25ec5eeb65425f904e0a25aaafdf5682ef9c
ToppCell	droplet-Liver-LIVER-NPC-1m-Epithelial-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GRHPR GCAT ASGR1 PXMP2	9.51e-05	177	60	4	1b077084b78e62ead603f72c9db6ce74a3953f81
ToppCell	metastatic_Brain-B_lymphocytes-GrB-secreting_B_cells\|B_lymphocytes / Location, Cell class and cell subclass	DMXL2 TMIGD2 SCT DCBLD2	9.51e-05	177	60	4	43e1d0d3cf8f0c02e67d91f8dd1761df23d59e07
ToppCell	droplet-Marrow-nan-18m-Lymphocytic-precursor_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DDR1 ROBO3 CLEC10A CTSL	9.93e-05	179	60	4	1757b9f3f4c634277a67c4f5a39d27d6b4937073
ToppCell	droplet-Spleen-nan-24m-Myeloid-macrophage_dendritic_cell_progenitor\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DDR1 ROBO3 CLEC10A CTSL	9.93e-05	179	60	4	d50d29f26d5a2cd8c4cd4e1244e1bb8de072d159
ToppCell	10x5'-lymph-node_spleen-Myeloid_Mac-Intestinal_macrophages\|lymph-node_spleen / Manually curated celltypes from each tissue	DMXL2 ITSN1 CLEC10A CTSL	1.01e-04	180	60	4	7be7d7a6906fff6dbdecd9cb013d855aba4eda2a
ToppCell	droplet-Kidney-nan-3m-Epithelial-kidney_proximal_straight_tubule_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NDRG1 LRP2 CTSL GRK1	1.01e-04	180	60	4	b34d933cdabf692f02eaaf65c2aaca1fb9510627
ToppCell	facs-Marrow-B-cells-3m-Myeloid-CD4+_macrophage\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DDR1 ROBO3 CLEC10A CTSL	1.01e-04	180	60	4	bf8d13d4db1af55b8c9fe16aaccf8743e000e005
ToppCell	droplet-Marrow-nan-3m-Lymphocytic-precursor_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DDR1 ROBO3 CLEC10A CTSL	1.01e-04	180	60	4	df60970520fba2ac0639faa54096766d07418ca4
ToppCell	droplet-Marrow-nan-24m-Lymphocytic-precursor_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DDR1 ROBO3 CLEC10A CTSL	1.01e-04	180	60	4	64f01494a4052186773720e10b4e7c724ff94547
ToppCell	facs-Marrow-B-cells-3m-Myeloid-macrophage\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DDR1 ROBO3 CLEC10A CTSL	1.01e-04	180	60	4	82965ed1b72a1873c24dd4553d39681596057316
ToppCell	Control-Myeloid-Alveolar_macrophages\|Control / group, cell type (main and fine annotations)	DMXL2 ACSM3 GPNMB CTSL	1.04e-04	181	60	4	8d2102c8c86c59a82610f26f90946b290552e666
ToppCell	droplet-Marrow-BM-1m-Lymphocytic-precursor_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DDR1 ROBO3 CLEC10A CTSL	1.04e-04	181	60	4	fb64da1dde37fe6ba7de2586cd58848ac1974f24
ToppCell	droplet-Kidney-KIDNEY-1m-Epithelial-epithelial_cell_of_proximal_tubule\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NDRG1 GRHPR LRP2 CTSL	1.06e-04	182	60	4	bdeebbfffc1308a29b721a5f8fed23a28d7a2f2f
ToppCell	droplet-Marrow-BM_(NON-STC)-30m-Lymphocytic-precursor_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DDR1 ROBO3 CLEC10A CTSL	1.06e-04	182	60	4	33afbb7c4352b03266501b1f4f0e751c12c7350d
ToppCell	droplet-Lung-1m-Epithelial-alveolar_epithelial-type_II_pneumocyte-type_2_alveolar_epithelial_cell\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	MYH7 GCAT PXMP2 LRP2	1.10e-04	184	60	4	24cbe9f2461ea920954e44bf3b2c2a6a5d4debfb
ToppCell	droplet-Lung-1m-Epithelial-alveolar_epithelial-type_II_pneumocyte\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	MYH7 GCAT PXMP2 LRP2	1.10e-04	184	60	4	98079fd048a63b51bbdf3833b6f15bf0ae99ea90
ToppCell	droplet-Lung-1m-Epithelial-alveolar_epithelial\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	MYH7 GCAT PXMP2 LRP2	1.10e-04	184	60	4	86c1551c4f7c7d0c35c14852b01b1e602fa5092a
ToppCell	droplet-Pancreas-Endocrine-21m-Epithelial-pancreatic_A_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACE2 SDF4 CTSL PBXIP1	1.13e-04	185	60	4	4e40d3103ebf4a7066b7ce300b6ef700ba0e2863
ToppCell	Adult-Immune-interstitial_macrophage_(C1Q_positive)-D175\|Adult / Lineage, Cell type, age group and donor	HSP90B1 DMXL2 ITSN1 CTSL	1.13e-04	185	60	4	ab5704b96f1d368911308797d10c7c52766ab134
ToppCell	droplet-Marrow-nan-21m-Lymphocytic-precursor_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DDR1 ROBO3 CLEC10A CTSL	1.13e-04	185	60	4	65dcb0a7ee64990a34a87c167b44497107f035ee
ToppCell	10x_5'_v1-Non-neoplastic-Myeloid-Mono-Mono_anti-infl-Z\|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	DMXL2 ITSN1 GPNMB CTSL	1.15e-04	186	60	4	f73cb91e74a806858650ae97f543fc779ba4cff8
ToppCell	myeloid-Dendritic_cell-Plasmacytoid_dendritic_cell\|Dendritic_cell / Lineage, cell class and subclass	HSP90B1 TMIGD2 SCT TP53I13	1.15e-04	186	60	4	858134580a09ed8a5eb6d6413d8ca9265904dfc1
ToppCell	10x_5'_v1-Non-neoplastic-Myeloid-Mono-Mono_anti-infl\|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	DMXL2 ITSN1 GPNMB CTSL	1.15e-04	186	60	4	8694ca16c9780729f4fba67ba20e35745f1eb4e9
ToppCell	droplet-Pancreas-Endocrine-18m-Epithelial-pancreatic_A_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACE2 HSP90B1 SDF4 PBXIP1	1.22e-04	189	60	4	ce3fbaf9642785c8adf6edaeae20998bca558928
ToppCell	facs-Large_Intestine-Proximal-24m-Epithelial-large_intestine_goblet_cell\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC2A10 NDRG1 SCT HSD11B2	1.22e-04	189	60	4	e11998c57609c5714705713ac3a32016d6d841dd
ToppCell	Severe-Myeloid-Macrophages-\|Severe / Condition, Lineage, Cell class and cell subclass	HSP90B1 ERAP2 CTSL PBXIP1	1.22e-04	189	60	4	769b52073a0f0543a72e9f32772321194b70cb2f
ToppCell	control-Myeloid-CD14_Monocytes_2\|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	DMXL2 ASGR1 CTSL LDLR	1.22e-04	189	60	4	7f78b5bb8195f99b18082cbb612e9199b7a1538c
ToppCell	control-Myeloid-CD14_Monocytes_2\|control / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	DMXL2 ASGR1 CTSL LDLR	1.25e-04	190	60	4	47513757e0059e8370e49672a577f25ca842e98c
ToppCell	droplet-Pancreas-Endocrine-18m-Epithelial-pancreatic_A_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACE2 HSP90B1 SDF4 PBXIP1	1.25e-04	190	60	4	db19c72d8c8053262b535068c5a9d4d696989cb1
ToppCell	Myeloid-Myeloid-B_(Activated_Macrophage)\|Myeloid / shred on cell class and cell subclass (v4)	HSP90B1 DMXL2 GPNMB CTSL	1.27e-04	191	60	4	7bf125249af1e8bb138ed4d999fdd74b03ab2447
ToppCell	NS-critical-d_07-13-Myeloid-Monocyte-derived_Macrophage\|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	ASGR1 GPNMB CLEC10A CTSL	1.33e-04	193	60	4	0dd83b21e164147abfd511a927615c40a28781a2
ToppCell	Adult-Immune-interstitial_macrophage_(C1Q_positive)\|Adult / Lineage, Cell type, age group and donor	DMXL2 ITSN1 CLEC10A CTSL	1.33e-04	193	60	4	31c0978ba78c9516d498aec0798902e57555e557
ToppCell	LA\|World / Chamber and Cluster_Paper	EPS8 ACSM3 ANXA8L1 LRP2	1.33e-04	193	60	4	d4bf89437216baf489ea0239136dcedf3b6714af
ToppCell	droplet-Marrow-BM_(NON-STC)-30m-Myeloid-promonocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPS8 PDIA6 GCAT CTSL	1.33e-04	193	60	4	5a201ee6f132357c9aacfbad3ae56ed9854c25fd
ToppCell	normal_Lymph_Node-B_lymphocytes-MALT_B_cells\|B_lymphocytes / Location, Cell class and cell subclass	BMP6 HSP90B1 PDIA6 LDLR	1.35e-04	194	60	4	1ca034f25a8fce503fb67654d7fa2a8ec71976be
ToppCell	Monocytes-Phagocytic_CD16+_macrophages\|Monocytes / Immune cells in Kidney/Urine in Lupus Nephritis	DMXL2 ASGR1 GPNMB CTSL	1.35e-04	194	60	4	40dbfdf1d7e6b73d120d8f802f08e573fe9a739e
ToppCell	critical-Myeloid-Monocyte-derived_Macrophage\|critical / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	ASGR1 GPNMB CLEC10A CTSL	1.35e-04	194	60	4	e36d1fd141bdcbd9ed66a33de6cdfde77189a0c1
ToppCell	367C-Myeloid-Macrophage-M2-like_Macrophage_(MARCO_negative)\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	EPS8 ITSN1 CLEC10A METTL27	1.38e-04	195	60	4	4008fa86b5166087a4b20f89ae07e1dfc87c855d
ToppCell	(3)_MNP-(3)_Macrophage_MARCOneg\|(3)_MNP / Lung cell shreds - cell class (v4) and cell subclass (v4)	EPS8 ITSN1 CLEC10A METTL27	1.38e-04	195	60	4	e4b5e4b8832669fb4d1661ecd828b81e621d35c4
ToppCell	10x5'-GI_small-bowel-Myeloid_Mac-Intestinal_macrophages\|GI_small-bowel / Manually curated celltypes from each tissue	DMXL2 GPNMB CLEC10A CTSL	1.41e-04	196	60	4	075e5746fa5cb121115a1d51b823c0fbf8d54305
ToppCell	ILEUM-inflamed-(3)_Resident_macrophages\|inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	DMXL2 GPNMB CLEC10A CTSL	1.41e-04	196	60	4	5ac246a823a8e1996325753858615269687b429d
ToppCell	367C-Myeloid-Macrophage-M2-like_Macrophage_(MARCO_negative)\|Macrophage / Donor, Lineage, Cell class and subclass (all cells)	EPS8 ITSN1 CLEC10A METTL27	1.41e-04	196	60	4	e8c4eeb4b6c6d9bccca2adb942d4cfbaab39636c
ToppCell	5'-Adult-LargeIntestine-Hematopoietic-Myeloid-Macrophages\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	DMXL2 GPNMB CLEC10A CTSL	1.44e-04	197	60	4	e698a0bbb20bd4868ff4348f2ac9f609942b55fa
ToppCell	390C-Myeloid-Monocyte-CD16+_Monocyte\|390C / Donor, Lineage, Cell class and subclass (all cells)	DMXL2 ASGR1 GPNMB CTSL	1.44e-04	197	60	4	01f5f5c34e904cc0146e978cc05ed1cd86a41533
ToppCell	PBMC-Severe-Myeloid-Classical_Monocyte-Classical_Monocyte-cMono_4\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	DMXL2 ASGR1 CTSL LDLR	1.44e-04	197	60	4	383d598ce3f8f5fc98bef3300e4cf7b6992aec9c
ToppCell	nucseq-Immune-Immune_Myeloid-IM\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	DMXL2 ITSN1 GPNMB CTSL	1.44e-04	197	60	4	6f41c8f815851968849428ec92c16745bd01a3fb
ToppCell	nucseq-Immune-Immune_Myeloid-IM-IM\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	DMXL2 ITSN1 GPNMB CTSL	1.44e-04	197	60	4	304044ace926943b8eb588f686ecbe5d1689a809
Computational	Genes upregulated in subsets of cells of a given type within various tumors	HSP90B1 PDIA6 NDRG1	7.69e-04	50	39	3	GAVISH_3CA_METAPROGRAM_MACROPHAGES_UNFOLDED_PROTEIN_RESPONSE
Computational	Genes upregulated in subsets of cells of a given type within various tumors	HSP90B1 PDIA6 CTSL	7.69e-04	50	39	3	GAVISH_3CA_MALIGNANT_METAPROGRAM_10_PROTEIN_MATURATION
Computational	Genes upregulated in subsets of cells of a given type within various tumors	NDRG1 GPNMB CTSL	7.69e-04	50	39	3	GAVISH_3CA_METAPROGRAM_MACROPHAGES_MES_GLYCOLYSIS
Computational	Genes upregulated in subsets of cells of a given type within various tumors	HSP90B1 PDIA6 CTSL	7.69e-04	50	39	3	GAVISH_3CA_METAPROGRAM_MACROPHAGES_PROTEASOMAL_DEGRADATION
Disease	Prostatic Neoplasms	DDR1 HSP90B1 ACSM3 NDRG1 GRHPR BAZ2A ITSN1 LRP2	3.39e-05	616	60	8	C0033578
Disease	Malignant neoplasm of prostate	DDR1 HSP90B1 ACSM3 NDRG1 GRHPR BAZ2A ITSN1 LRP2	3.39e-05	616	60	8	C0376358
Disease	DEAFNESS, AUTOSOMAL RECESSIVE (disorder)	EPS8 DMXL2	3.13e-04	13	60	2	C1846647
Disease	urokinase plasminogen activator surface receptor measurement	ASGR1 DCBLD2	3.64e-04	14	60	2	EFO_0010932
Disease	hypertrophic cardiomyopathy (is_implicated_in)	MYH7 CTSL	9.15e-04	22	60	2	DOID:11984 (is_implicated_in)
Disease	Sensorineural Hearing Loss (disorder)	DMXL2 LRP2	1.00e-03	23	60	2	C0018784
Disease	apolipoprotein A 1 measurement, apolipoprotein B measurement	ASGR1 SP6 LDLR	1.37e-03	107	60	3	EFO_0004614, EFO_0004615
Disease	antihyperlipidemic drug use measurement	ASGR1 SP6 LDLR	1.68e-03	115	60	3	EFO_0803367

Protein segments in the cluster

Peptide	Gene	Start	Entry
GHSWWRMWDGPTGAA	nan	36	Q8NBF4
WMGLHDQNGPWKWVD	ASGR1	211	P07306
MVWPWVAMASRWGPL	SDF4	1	Q9BRK5
MAEGEDVGWWRSWLQ	BSDC1	1	Q9NW68
SMDSDWGAWWGVSLP	BAALC-AS2	66	P0C853
CSGWWWIRDPEMLDA	BAZ2A	1436	Q9UIF9
GRRWMGWKDRWGQEV	DDR1	126	Q08345
VWKRGDMRWKNSWKG	GPNMB	61	Q14956
PPAQEEGMTWWYRWL	CACFD1	16	Q9UGQ2
QWSELRAMGIGWWVR	DMXL2	1626	Q8TDJ6
MERWPWPSGGAWLLV	HSD11B2	1	P80365
LRNPWGKVEWKGDWS	CAPN14	276	A8MX76
WGLALEMAWVEPAWA	TP53I13	111	Q8NBR0
WNIRAFMGVKNWPWM	MYH7	816	P12883
MAWWKSWIEQEGVTV	ANXA8	1	P13928
GADWGIGWWTAVVIM	LYSMD3	211	Q7Z3D4
IKWPDTNDIVWGKVW	MGAM2	1296	Q2M2H8
WRGWTVAMKNGVQWA	MYO15A	2261	Q9UKN7
ALAGTPWGWRHMFGW	SLC2A10	156	O95528
PWGWRHMFGWATAPA	SLC2A10	161	O95528
MEILSNWGNSWWVGL	KATNIP	481	O60303
GWMDWAASKISGWTQ	NDRG1	171	Q92597
RGWKAWMHQQERGGW	NRDE2	536	Q9H7Z3
EWLWWAGLLSMGAGE	NIPA2	56	Q8N8Q9
MPFLGQDWRSPGWSW	FBXO25	1	Q8TCJ0
WTDWGKEPKIESAWM	LRP2	4201	P98164
MWPGNAWRAALFWVP	GCAT	1	O75600
GMWEGLVAWPVDRLW	METTL27	191	Q8N6F8
WDWELMNDIKPIWQR	HSP90B1	331	P14625
WGWVLATESRMHWPG	GABRR1	16	P24046
MAWWKAWIEQEGVTV	ANXA8L1	1	Q5VT79
NPAWWHGQPMWLTAM	ENPP3	246	O14638
QDMWWFGEVQGQKGW	ITSN1	946	Q15811
EEVKNGGWTSWKPLW	GRHPR	131	Q9UBQ7
MPGLGRRAQWLCWWW	BMP6	1	P22004
GEIPKDQWMKKWWEM	ACE2	466	Q9BYF1
AGSAEWTWGWMKRLP	FAM167A-AS1	41	Q96KT0
VTMEWWNDIWLKEGF	ERAP2	381	Q6P179
GMAVIDWEEWRPTWA	SPAM1	141	P38567
WMSLGGTWMKARAEW	EPS8	406	Q12929
DLPYWDRAGWWKGMK	DCBLD2	566	Q96PD2
SLMPLWWNGSEPLWV	ENPP6	111	Q6UWR7
QWKWLEAQPMGEDWF	GRK1	176	Q15835
LQAWMPLDGTWSPWL	SCT	86	P09683
GRKWWMGAEEPWQTL	POLRMT	881	O00411
MWGWLWTEAGAQSEL	PDIA6	331	Q15084
VGFVGRWWVLGAWMR	TIMM29	166	Q9BSF4
ESLWGRSVWPPMVWL	FER1L5	1161	A0AVI2
DWMVHWMWGRGLDPD	SLC41A1	461	Q8IVJ1
EDGSWWDLHPGTSWM	SP6	116	Q3SY56
WLVKNSWGEEWGMGG	CTSL	296	P07711
PAFWWINRNGEEMRW	ACSM3	81	Q53FZ2
YTWMGLSDPEGAWKW	CLEC10A	236	Q8IUN9
WDSRMEGLWKWNDRI	ZNF624	161	Q9P2J8
MGVAAIVWGAWFWGR	TMIGD2	161	Q96BF3
EWSGKEKWWDGQRDR	PBXIP1	471	Q96AQ6
SLEGAWPWQASMQWK	TMPRSS11B	191	Q86T26
GGFWPALRMNWRVWT	PXMP2	146	Q9NR77
TWSGWLKMREDWGVS	ROBO3	531	Q96MS0
RGPWWDDWERDQDMD	YLPM1	1261	P49750
PWASWGALTDQSWGM	ZNF606	6	Q8WXB4
MGPWGWKLRWTVALL	LDLR	1	P01130