Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	glucosamine-6-phosphate deaminase activity	GNPDA1 GNPDA2	6.14e-06	2	50	2	GO:0004342
GeneOntologyMolecularFunction	deaminase activity	AMPD3 GNPDA1 GNPDA2	8.37e-05	34	50	3	GO:0019239
GeneOntologyMolecularFunction	transferase activity, transferring phosphorus-containing groups	STK36 BMPR1B TENT4B PDGFRA IKBKE STK33 TBK1 NEK7 DLG2	4.73e-04	938	50	9	GO:0016772
GeneOntologyMolecularFunction	kinase activity	STK36 BMPR1B PDGFRA IKBKE STK33 TBK1 NEK7 DLG2	5.72e-04	764	50	8	GO:0016301
GeneOntologyMolecularFunction	protein kinase activity	STK36 BMPR1B PDGFRA IKBKE STK33 TBK1 NEK7	6.95e-04	600	50	7	GO:0004672
GeneOntologyMolecularFunction	protein serine/threonine kinase activity	STK36 BMPR1B IKBKE STK33 TBK1 NEK7	8.30e-04	446	50	6	GO:0004674
GeneOntologyBiologicalProcess	glucosamine catabolic process	GNPDA1 GNPDA2	5.76e-06	2	50	2	GO:0006043
GeneOntologyBiologicalProcess	N-acetylglucosamine catabolic process	GNPDA1 GNPDA2	1.73e-05	3	50	2	GO:0006046
GeneOntologyBiologicalProcess	glucosamine metabolic process	GNPDA1 GNPDA2	8.59e-05	6	50	2	GO:0006041
GeneOntologyBiologicalProcess	N-acetylneuraminate catabolic process	GNPDA1 GNPDA2	1.20e-04	7	50	2	GO:0019262
GeneOntologyCellularComponent	spindle pole	TUBGCP6 KNTC1 TOPBP1 NEK7 CSPP1	1.41e-04	205	51	5	GO:0000922
Domain	Glucosamine6P_isomerase_CS	GNPDA1 GNPDA2	7.02e-06	2	50	2	IPR018321
Domain	Glucosamine6P_isomerase	GNPDA1 GNPDA2	7.02e-06	2	50	2	IPR004547
Domain	GLC_GALNAC_ISOMERASE	GNPDA1 GNPDA2	7.02e-06	2	50	2	PS01161
Domain	Glc/Gal-6P_isomerase	GNPDA1 GNPDA2	4.20e-05	4	50	2	IPR006148
Domain	Glucosamine_iso	GNPDA1 GNPDA2	4.20e-05	4	50	2	PF01182
Domain	S_TKc	STK36 BMPR1B PDGFRA IKBKE STK33 TBK1 NEK7	4.49e-05	359	50	7	SM00220
Domain	Protein_kinase_ATP_BS	STK36 BMPR1B PDGFRA IKBKE STK33 TBK1 NEK7	6.32e-05	379	50	7	IPR017441
Domain	PROTEIN_KINASE_ATP	STK36 BMPR1B PDGFRA IKBKE STK33 TBK1 NEK7	2.07e-04	459	50	7	PS00107
Domain	Prot_kinase_dom	STK36 BMPR1B PDGFRA IKBKE STK33 TBK1 NEK7	3.05e-04	489	50	7	IPR000719
Domain	PROTEIN_KINASE_DOM	STK36 BMPR1B PDGFRA IKBKE STK33 TBK1 NEK7	3.20e-04	493	50	7	PS50011
Domain	Ser/Thr_kinase_AS	STK36 BMPR1B IKBKE STK33 TBK1 NEK7	3.66e-04	357	50	6	IPR008271
Domain	PROTEIN_KINASE_ST	STK36 BMPR1B IKBKE STK33 TBK1 NEK7	3.94e-04	362	50	6	PS00108
Domain	Pkinase	STK36 BMPR1B IKBKE STK33 TBK1 NEK7	5.16e-04	381	50	6	PF00069
Domain	Kinase-like_dom	STK36 BMPR1B PDGFRA IKBKE STK33 TBK1 NEK7	5.64e-04	542	50	7	IPR011009
Domain	Ser-Thr/Tyr_kinase_cat_dom	BMPR1B PDGFRA NEK7	6.00e-03	138	50	3	IPR001245
Domain	CUB	TLL2 OVCH1	7.62e-03	49	50	2	PF00431
Domain	CUB	TLL2 OVCH1	7.93e-03	50	50	2	SM00042
Domain	-	TLL2 OVCH1	8.55e-03	52	50	2	2.60.120.290
Domain	CUB	TLL2 OVCH1	8.87e-03	53	50	2	PS01180
Domain	CUB_dom	TLL2 OVCH1	1.02e-02	57	50	2	IPR000859
Pubmed	Identification of TBK1 and IKKε, the non-canonical IκB kinases, as crucial pro-survival factors in HTLV-1-transformed T lymphocytes.	IKBKE TBK1	2.19e-06	2	52	2	27123832
Pubmed	IKKε and TBK1 expression in gastric cancer.	IKBKE TBK1	2.19e-06	2	52	2	27145266
Pubmed	Two mammalian glucosamine-6-phosphate deaminases: a structural and genetic study.	GNPDA1 GNPDA2	2.19e-06	2	52	2	12965206
Pubmed	Inhibition of TBK1/IKKε Promotes Regeneration of Pancreatic β-cells.	IKBKE TBK1	2.19e-06	2	52	2	30349097
Pubmed	Activation of TBK1 and IKKvarepsilon kinases by vesicular stomatitis virus infection and the role of viral ribonucleoprotein in the development of interferon antiviral immunity.	IKBKE TBK1	2.19e-06	2	52	2	15367631
Pubmed	IKKε and TBK1 in diffuse large B-cell lymphoma: A possible mechanism of action of an IKKε/TBK1 inhibitor to repress NF-κB and IL-10 signalling.	IKBKE TBK1	2.19e-06	2	52	2	32858764
Pubmed	Cloning and functional characterization of GNPI2, a novel human homolog of glucosamine-6-phosphate isomerase/oscillin.	GNPDA1 GNPDA2	2.19e-06	2	52	2	12616532
Pubmed	Carboxylic Acid Derivatives of Amlexanox Display Enhanced Potency toward TBK1 and IKKε and Reveal Mechanisms for Selective Inhibition.	IKBKE TBK1	2.19e-06	2	52	2	30082428
Pubmed	Nuclear accumulation of cRel following C-terminal phosphorylation by TBK1/IKK epsilon.	IKBKE TBK1	2.19e-06	2	52	2	16888014
Pubmed	Increased IKKϵ protein stability ensures efficient type I interferon responses in conditions of TBK1 deficiency.	IKBKE TBK1	2.19e-06	2	52	2	36936901
Pubmed	Hepatitis C virus NS2 protease inhibits host cell antiviral response by inhibiting IKKε and TBK1 functions.	IKBKE TBK1	2.19e-06	2	52	2	23096996
Pubmed	The roles of two IkappaB kinase-related kinases in lipopolysaccharide and double stranded RNA signaling and viral infection.	IKBKE TBK1	2.19e-06	2	52	2	15210742
Pubmed	Cutting edge: Role of TANK-binding kinase 1 and inducible IkappaB kinase in IFN responses against viruses in innate immune cells.	IKBKE TBK1	2.19e-06	2	52	2	17056502
Pubmed	Molecular basis of Tank-binding kinase 1 activation by transautophosphorylation.	IKBKE TBK1	2.19e-06	2	52	2	22619329
Pubmed	The kinases IKBKE and TBK1 regulate MYC-dependent survival pathways through YB-1 in AML and are targets for therapy.	IKBKE TBK1	2.19e-06	2	52	2	30504235
Pubmed	Functionally distinct effects of the C-terminal regions of IKKε and TBK1 on type I IFN production.	IKBKE TBK1	2.19e-06	2	52	2	24722368
Pubmed	Are the IKKs and IKK-related kinases TBK1 and IKK-epsilon similarly activated?	IKBKE TBK1	2.19e-06	2	52	2	18353649
Pubmed	The non-canonical IκB kinases IKKε and TBK1 as potential targets for the development of novel therapeutic drugs.	IKBKE TBK1	2.19e-06	2	52	2	23157677
Pubmed	Crystal structure and mechanism of activation of TANK-binding kinase 1.	IKBKE TBK1	2.19e-06	2	52	2	23453971
Pubmed	Importance of Validating Antibodies and Small Compound Inhibitors Using Genetic Knockout Studies-T Cell Receptor-Induced CYLD Phosphorylation by IKKε/TBK1 as a Case Study.	IKBKE TBK1	6.57e-06	3	52	2	29755980
Pubmed	ORF45 of Kaposi's sarcoma-associated herpesvirus inhibits phosphorylation of interferon regulatory factor 7 by IKKε and TBK1 as an alternative substrate.	IKBKE TBK1	6.57e-06	3	52	2	22787218
Pubmed	Viral suppression of innate immunity via spatial isolation of TBK1/IKKε from mitochondrial antiviral platform.	IKBKE TBK1	6.57e-06	3	52	2	24706939
Pubmed	HTLV-1 Tax protein recruitment into IKKε and TBK1 kinase complexes enhances IFN-I expression.	IKBKE TBK1	6.57e-06	3	52	2	25531185
Pubmed	Modulation of the interferon antiviral response by the TBK1/IKKi adaptor protein TANK.	IKBKE TBK1	6.57e-06	3	52	2	17327220
Pubmed	TBK1 and IKKε act like an OFF switch to limit NLRP3 inflammasome pathway activation.	IKBKE TBK1	6.57e-06	3	52	2	34518217
Pubmed	SOCS3 Drives Proteasomal Degradation of TBK1 and Negatively Regulates Antiviral Innate Immunity.	IKBKE TBK1	6.57e-06	3	52	2	25939384
Pubmed	Promoter organization of the interferon-A genes differentially affects virus-induced expression and responsiveness to TBK1 and IKKepsilon.	IKBKE TBK1	6.57e-06	3	52	2	16380379
Pubmed	Phosphorylation of RAB7 by TBK1/IKKε Regulates Innate Immune Signaling in Triple-Negative Breast Cancer.	IKBKE TBK1	6.57e-06	3	52	2	31662325
Pubmed	Evasion of antiviral immunity through sequestering of TBK1/IKKε/IRF3 into viral inclusion bodies.	IKBKE TBK1	6.57e-06	3	52	2	24335286
Pubmed	Peroxiredoxin 1 Interacts with TBK1/IKKε and Negatively Regulates Pseudorabies Virus Propagation by Promoting Innate Immunity.	IKBKE TBK1	6.57e-06	3	52	2	34260286
Pubmed	IKK-i and TBK-1 are enzymatically distinct from the homologous enzyme IKK-2: comparative analysis of recombinant human IKK-i, TBK-1, and IKK-2.	IKBKE TBK1	6.57e-06	3	52	2	11839743
Pubmed	The Loss of TBK1 Kinase Activity in Motor Neurons or in All Cell Types Differentially Impacts ALS Disease Progression in SOD1 Mice.	IKBKE TBK1	6.57e-06	3	52	2	32220666
Pubmed	A20 is a negative regulator of IFN regulatory factor 3 signaling.	IKBKE TBK1	6.57e-06	3	52	2	15661910
Pubmed	Inflammation produces catecholamine resistance in obesity via activation of PDE3B by the protein kinases IKKε and TBK1.	IKBKE TBK1	6.57e-06	3	52	2	24368730
Pubmed	Mitochondria-associated membrane collapse impairs TBK1-mediated proteostatic stress response in ALS.	IKBKE TBK1	1.31e-05	4	52	2	37967220
Pubmed	Genetically programmed alternative splicing of NEMO mediates an autoinflammatory disease phenotype.	IKBKE TBK1	1.31e-05	4	52	2	35289316
Pubmed	TBK1 and IKKε Act Redundantly to Mediate STING-Induced NF-κB Responses in Myeloid Cells.	IKBKE TBK1	1.31e-05	4	52	2	32268090
Pubmed	SIKE is an IKK epsilon/TBK1-associated suppressor of TLR3- and virus-triggered IRF-3 activation pathways.	IKBKE TBK1	1.31e-05	4	52	2	16281057
Pubmed	Suppression of innate antiviral response by severe acute respiratory syndrome coronavirus M protein is mediated through the first transmembrane domain.	IKBKE TBK1	1.31e-05	4	52	2	24509444
Pubmed	TLR-driven early glycolytic reprogramming via the kinases TBK1-IKKɛ supports the anabolic demands of dendritic cell activation.	IKBKE TBK1	1.31e-05	4	52	2	24562310
Pubmed	Ebola virus protein VP35 impairs the function of interferon regulatory factor-activating kinases IKKepsilon and TBK-1.	IKBKE TBK1	1.31e-05	4	52	2	19153231
Pubmed	IKKε and TBK1 prevent RIPK1 dependent and independent inflammation.	IKBKE TBK1	1.31e-05	4	52	2	38167258
Pubmed	Estrogen receptor alpha inhibits RLR-mediated immune response via ubiquitinating TRAF3.	IKBKE TBK1	1.31e-05	4	52	2	26186972
Pubmed	TTLL12 Inhibits the Activation of Cellular Antiviral Signaling through Interaction with VISA/MAVS.	IKBKE TBK1	1.31e-05	4	52	2	28011935
Pubmed	A CRM1-dependent nuclear export pathway is involved in the regulation of IRF-5 subcellular localization.	IKBKE TBK1	1.31e-05	4	52	2	15556946
Pubmed	The E3 Ubiquitin Ligase TBK1 Mediates the Degradation of Multiple Picornavirus VP3 Proteins by Phosphorylation and Ubiquitination.	IKBKE TBK1	1.31e-05	4	52	2	31534043
Pubmed	Regulation of IkappaB kinase-related kinases and antiviral responses by tumor suppressor CYLD.	IKBKE TBK1	1.31e-05	4	52	2	18467330
Pubmed	An oligodendrocyte enhancer in a phylogenetically conserved intron region of the mammalian myelin gene Opalin.	TLL2 OPALIN	1.31e-05	4	52	2	17442045
Pubmed	Association of a Network of Interferon-Stimulated Genes with a Locus Encoding a Negative Regulator of Non-conventional IKK Kinases and IFNB1.	IKBKE TBK1	1.31e-05	4	52	2	27705791
Pubmed	Functional dissection of the TBK1 molecular network.	IKBKE TBK1	1.31e-05	4	52	2	21931631
Pubmed	Comparison of substrate specificity of the ubiquitin ligases Nedd4 and Nedd4-2 using proteome arrays.	BMPR1B PDGFRA TBK1 RASGEF1A DMTN	1.34e-05	203	52	5	19953087
Pubmed	TRAF6-dependent Act1 phosphorylation by the IκB kinase-related kinases suppresses interleukin-17-induced NF-κB activation.	IKBKE TBK1	2.19e-05	5	52	2	22851696
Pubmed	IκB kinase ε-dependent phosphorylation and degradation of X-linked inhibitor of apoptosis sensitizes cells to virus-induced apoptosis.	IKBKE TBK1	2.19e-05	5	52	2	22072751
Pubmed	The Ret finger protein inhibits signaling mediated by the noncanonical and canonical IkappaB kinase family members.	IKBKE TBK1	2.19e-05	5	52	2	16393995
Pubmed	IkappaB kinase epsilon and TANK-binding kinase 1 activate AKT by direct phosphorylation.	IKBKE TBK1	2.19e-05	5	52	2	21464307
Pubmed	Selective autophagy controls the stability of TBK1 via NEDD4 to balance host defense.	IKBKE TBK1	2.19e-05	5	52	2	34257412
Pubmed	RING finger protein 11 targets TBK1/IKKi kinases to inhibit antiviral signaling.	IKBKE TBK1	2.19e-05	5	52	2	23308279
Pubmed	A novel IRAK1-IKKε signaling axis limits the activation of TAK1-IKKβ downstream of TLR3.	IKBKE TBK1	2.19e-05	5	52	2	23396947
Pubmed	Involvement of the IkappaB kinase (IKK)-related kinases tank-binding kinase 1/IKKi and cullin-based ubiquitin ligases in IFN regulatory factor-3 degradation.	IKBKE TBK1	2.19e-05	5	52	2	17015689
Pubmed	The NEMO adaptor bridges the nuclear factor-kappaB and interferon regulatory factor signaling pathways.	IKBKE TBK1	2.19e-05	5	52	2	17468758
Pubmed	Identification of the protein kinases that activate the E3 ubiquitin ligase Pellino 1 in the innate immune system.	IKBKE TBK1	2.19e-05	5	52	2	22007846
Pubmed	The SARS-CoV-2 papain-like protease suppresses type I interferon responses by deubiquitinating STING.	IKBKE TBK1	2.19e-05	5	52	2	37130168
Pubmed	Hexosamine biosynthesis in keratinocytes: roles of GFAT and GNPDA enzymes in the maintenance of UDP-GlcNAc content and hyaluronan synthesis.	GNPDA1 GNPDA2	2.19e-05	5	52	2	26887390
Pubmed	NOD1 contributes to mouse host defense against Helicobacter pylori via induction of type I IFN and activation of the ISGF3 signaling pathway.	IKBKE TBK1	2.19e-05	5	52	2	20389019
Pubmed	A role for APPL1 in TLR3/4-dependent TBK1 and IKKε activation in macrophages.	IKBKE TBK1	2.19e-05	5	52	2	25780039
Pubmed	Induction of IRF-3 and IRF-7 phosphorylation following activation of the RIG-I pathway.	IKBKE TBK1	2.19e-05	5	52	2	16914100
Pubmed	Regulation of T-cell activation and migration by the kinase TBK1 during neuroinflammation.	IKBKE TBK1	2.19e-05	5	52	2	25606824
Pubmed	ABIN1 protein cooperates with TAX1BP1 and A20 proteins to inhibit antiviral signaling.	IKBKE TBK1	3.28e-05	6	52	2	21885437
Pubmed	SARS coronavirus papain-like protease inhibits the type I interferon signaling pathway through interaction with the STING-TRAF3-TBK1 complex.	IKBKE TBK1	3.28e-05	6	52	2	24622840
Pubmed	The interferon regulatory factor, IRF5, is a central mediator of toll-like receptor 7 signaling.	IKBKE TBK1	3.28e-05	6	52	2	15695821
Pubmed	NAK-associated protein 1 participates in both the TLR3 and the cytoplasmic pathways in type I IFN induction.	IKBKE TBK1	3.28e-05	6	52	2	17142768
Pubmed	UBL7 enhances antiviral innate immunity by promoting Lys27-linked polyubiquitination of MAVS.	IKBKE TBK1	3.28e-05	6	52	2	36943869
Pubmed	Identification of NAP1, a regulatory subunit of IkappaB kinase-related kinases that potentiates NF-kappaB signaling.	IKBKE TBK1	3.28e-05	6	52	2	14560022
Pubmed	Virus subtype-specific suppression of MAVS aggregation and activation by PB1-F2 protein of influenza A (H7N9) virus.	IKBKE TBK1	3.28e-05	6	52	2	32511263
Pubmed	SARS-CoV-2 Membrane Protein Inhibits Type I Interferon Production Through Ubiquitin-Mediated Degradation of TBK1.	IKBKE TBK1	3.28e-05	6	52	2	34084167
Pubmed	FGF21 is required for the metabolic benefits of IKKε/TBK1 inhibition.	IKBKE TBK1	3.28e-05	6	52	2	33822771
Pubmed	Targeting liquid-liquid phase separation of SARS-CoV-2 nucleocapsid protein promotes innate antiviral immunity by elevating MAVS activity.	IKBKE TBK1	3.28e-05	6	52	2	34239064
Pubmed	Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.	STK36 TOPBP1 ZNFX1 CADPS2	4.39e-05	130	52	4	12421765
Pubmed	MCPIP1 negatively regulate cellular antiviral innate immune responses through DUB and disruption of TRAF3-TBK1-IKKε complex.	IKBKE TBK1	4.58e-05	7	52	2	29920243
Pubmed	IL-17-receptor-associated adaptor Act1 directly stabilizes mRNAs to mediate IL-17 inflammatory signaling.	IKBKE TBK1	4.58e-05	7	52	2	29563620
Pubmed	Quantitative Proteomics Identified TTC4 as a TBK1 Interactor and a Positive Regulator of SeV-Induced Innate Immunity.	IKBKE TBK1	4.58e-05	7	52	2	29251827
Pubmed	A distinct role of Riplet-mediated K63-Linked polyubiquitination of the RIG-I repressor domain in human antiviral innate immune responses.	IKBKE TBK1	4.58e-05	7	52	2	23950712
Pubmed	The tumour suppressor CYLD is a negative regulator of RIG-I-mediated antiviral response.	IKBKE TBK1	4.58e-05	7	52	2	18636086
Pubmed	TRIM7 inhibits encephalomyocarditis virus replication by activating interferon-β signaling pathway.	IKBKE TBK1	4.58e-05	7	52	2	37023504
Pubmed	Contribution of a TANK-binding kinase 1-interferon (IFN) regulatory factor 7 pathway to IFN-γ-induced gene expression.	IKBKE TBK1	4.58e-05	7	52	2	22252317
Pubmed	MIP-T3 is a negative regulator of innate type I IFN response.	IKBKE TBK1	4.58e-05	7	52	2	22079989
Pubmed	Severe acute respiratory syndrome coronavirus M protein inhibits type I interferon production by impeding the formation of TRAF3.TANK.TBK1/IKKepsilon complex.	IKBKE TBK1	4.58e-05	7	52	2	19380580
Pubmed	The Type I Interferon-IRF7 Axis Mediates Transcriptional Expression of Usp25 Gene.	IKBKE TBK1	4.58e-05	7	52	2	27129230
Pubmed	IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway.	IKBKE TBK1	4.58e-05	7	52	2	12692549
Pubmed	E3 ubiquitin ligase ASB8 negatively regulates interferon via regulating TBK1/IKKi homeostasis.	IKBKE TBK1	4.58e-05	7	52	2	32298923
Pubmed	Reciprocal regulation of STING and TCR signaling by mTORC1 for T-cell activation and function.	IKBKE TBK1	4.58e-05	7	52	2	30683688
Pubmed	Association of the adaptor TANK with the I kappa B kinase (IKK) regulator NEMO connects IKK complexes with IKK epsilon and TBK1 kinases.	IKBKE TBK1	4.58e-05	7	52	2	12133833
Pubmed	Lipopolysaccharide-mediated interferon regulatory factor activation involves TBK1-IKKepsilon-dependent Lys(63)-linked polyubiquitination and phosphorylation of TANK/I-TRAF.	IKBKE TBK1	4.58e-05	7	52	2	17823124
Pubmed	Vaccinia virus protein C6 is a virulence factor that binds TBK-1 adaptor proteins and inhibits activation of IRF3 and IRF7.	IKBKE TBK1	4.58e-05	7	52	2	21931555
Pubmed	A Toll-like receptor-independent antiviral response induced by double-stranded B-form DNA.	IKBKE TBK1	4.58e-05	7	52	2	16286919
Pubmed	Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects.	FDFT1 SMIM29 DLG2 CADPS2	4.94e-05	134	52	4	24324551
Pubmed	POH1 contributes to hyperactivation of TGF-β signaling and facilitates hepatocellular carcinoma metastasis through deubiquitinating TGF-β receptors and caveolin-1.	LRIG3 PSMC1 DLG2 DDX39A MVP	5.92e-05	277	52	5	30745168
Pubmed	The TBK1 adaptor and autophagy receptor NDP52 restricts the proliferation of ubiquitin-coated bacteria.	IKBKE TBK1	6.10e-05	8	52	2	19820708
Pubmed	SINTBAD, a novel component of innate antiviral immunity, shares a TBK1-binding domain with NAP1 and TANK.	IKBKE TBK1	6.10e-05	8	52	2	17568778
Pubmed	Hippo signalling governs cytosolic nucleic acid sensing through YAP/TAZ-mediated TBK1 blockade.	IKBKE TBK1	6.10e-05	8	52	2	28346439
Cytoband	10q23-q24	TLL2 OPALIN	4.51e-05	9	52	2	10q23-q24
Cytoband	12q14.1	LRIG3 TBK1	4.67e-04	28	52	2	12q14.1
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	BMPR1B CROT STK33 DLG2 CADPS2	2.35e-06	183	52	5	b5ede5a0048c585b73c00e88aeddbcaf669347b1
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	FDFT1 DLG2 HAL CADPS2 MVP	2.54e-06	186	52	5	acfa68a2afb7d2b51c9b469a1965fe5cc5d5e64e
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	BMPR1B HAL CADPS2 ZNF98	2.62e-05	147	52	4	b66ccc710b3c04f6fc7fed69f3c892fc110e98fc
ToppCell	Children_(3_yrs)-Epithelial-basal_cell-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	LRIG3 BMPR1B CROT PTPN14	3.39e-05	157	52	4	6ee2692f705bdd93ba523dffaf2f0cd921b47e28
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	LRIG3 BMPR1B PTPN14 CADPS2	3.56e-05	159	52	4	8680b054622f573a82b1625fb93c2d5db81d1034
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Principal_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	BMPR1B STK33 DLG2 CADPS2	3.83e-05	162	52	4	285e6d553f485fd9f1075c4e1b940da251b5ea35
ToppCell	356C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_6\|356C / Donor, Lineage, Cell class and subclass (all cells)	TUBGCP6 CROT TENT4B PDZD4	4.21e-05	166	52	4	c4f7ea1cad962b1d6ad77423d15978b68a0d6f1d
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.0.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	STK33 AGBL2 GRM5 CSPP1	4.52e-05	169	52	4	14aadc2d1bf66eb47dac33b4d61ddb3c942caa4f
ToppCell	PND14-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_mature\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PTPN14 SLCO2B1 TLL2 DMTN	4.73e-05	171	52	4	686f95892c3909973c66c9a27159a070a068f175
ToppCell	PND14-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PTPN14 SLCO2B1 TLL2 DMTN	4.73e-05	171	52	4	f7ba03e7bdb687f93782c936c7b3374cc5b3b77c
ToppCell	PND14-Endothelial-Endothelial_lymphatic\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PTPN14 SLCO2B1 TLL2 DMTN	4.73e-05	171	52	4	d0ac50071a3854d02113c455fcc940a6ec59bbb9
ToppCell	PND14-Endothelial-Endothelial_lymphatic-Lymphatic_EC\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PTPN14 SLCO2B1 TLL2 DMTN	4.73e-05	171	52	4	fbf8e9db00573adcada4b25730e191417b7c9999
ToppCell	356C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_6\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	TUBGCP6 CROT TENT4B PDZD4	4.84e-05	172	52	4	a9e13aa36087170dadca421ba9de588e5a1cf715
ToppCell	droplet-Lung-21m-Hematologic-lymphocytic-regulatory_T_cell-regulatory_T_cell\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	KNTC1 IKBKE DLG2 ECEL1	5.41e-05	177	52	4	fd4a297e519b3959811a462d63feebff76429031
ToppCell	5'-Adult-Appendix-Endothelial-lymphatic_endothelial-LEC5_(CLDN11+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PTPN14 COLGALT2 DMTN PDZD4	5.41e-05	177	52	4	3a85aa2bf3f2fdbea57d22d68e022cb3f6c2eb65
ToppCell	droplet-Lung-21m-Hematologic-lymphocytic-regulatory_T_cell\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	KNTC1 IKBKE DLG2 ECEL1	5.41e-05	177	52	4	e995230ef207dcd87eab4550617589016ffa9970
ToppCell	Children_(3_yrs)-Epithelial-basal_cell\|Children_(3_yrs) / Lineage, Cell type, age group and donor	LRIG3 BMPR1B CROT PTPN14	5.53e-05	178	52	4	fba2e38c05cbf031e0c6d47b1602575fea734a57
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	BMPR1B STK33 DLG2 CADPS2	5.77e-05	180	52	4	023ec0b080c8a5cd0f36e83c6b17d4be3c01edb5
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	BMPR1B STK33 CADPS2 ZNF98	5.77e-05	180	52	4	788d5fbf688365b5d92d3aa19b9f8e9448f8be5a
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	BMPR1B STK33 DLG2 CADPS2	5.90e-05	181	52	4	aa233b652921848af2257cc3687a7a09c3acfb67
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Principal_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	BMPR1B STK33 CADPS2 ZNF98	6.03e-05	182	52	4	f96095b81188b52db8fcfca4837129cfcd9bd7b7
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Principal_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	BMPR1B STK33 CADPS2 ZNF98	6.16e-05	183	52	4	d340ab5a77e8d819a1dfb4ca3e9a4b9bc988923c
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)-Exc_L3-4_RORB_RPS3P6\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	LRIG3 BMPR1B STK33 CADPS2	6.42e-05	185	52	4	10da5c2a92bfb3248d3f6f94a0933996326cf590
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	BMPR1B STK33 DLG2 CADPS2	6.42e-05	185	52	4	d602a9b35e86e6f2a14a58e40fc4fb97f5fa3b08
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Principal_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	BMPR1B STK33 CADPS2 ZNF98	6.69e-05	187	52	4	f6217d0dd425eac76900b44a4e48f45475f3ac36
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	BMPR1B STK33 DLG2 CADPS2	6.69e-05	187	52	4	e3095455d2f255854f339f6b05fa87852af0700f
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	BMPR1B STK33 DLG2 CADPS2	6.98e-05	189	52	4	3a295c215b5c18e7c673f92b7af5be523421682c
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	BMPR1B STK33 DLG2 CADPS2	6.98e-05	189	52	4	fc88c51ace7d883c01617f3f9b5fab70cc91cc09
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	BMPR1B STK33 CADPS2 ZNF98	6.98e-05	189	52	4	8ff3c3232eff9de4b5c9b22ecb82bc509d773f58
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	BMPR1B STK33 CADPS2 ZNF98	7.12e-05	190	52	4	4836ea19308d2a96694f12ab0653b7ce7b101d2f
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	BMPR1B STK33 CADPS2 ZNF98	7.12e-05	190	52	4	b3bccf4dd95e986db3cee324a6737f5fcc22e8e5
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Degenerative_Outer_Medullary_Collecting_Duct_Principal_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	BMPR1B STK33 DLG2 CADPS2	7.41e-05	192	52	4	0bb06738e1c3ec0c044a7ee61f6cf1d4781fb53c
ToppCell	NS-critical-d_07-13-Epithelial-Secretory\|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	LRIG3 BMPR1B PER2 CADPS2	7.72e-05	194	52	4	2172d951896265243d14996eacce5aab5e14e26e
ToppCell	Parenchymal-NucSeq-Epithelial-Epi_airway_basal-Basal\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	LRIG3 BMPR1B CROT PTPN14	7.87e-05	195	52	4	6c9c58322c1df891bb4bab56dacb542c8777bb7d
ToppCell	Parenchymal-NucSeq-Epithelial-Epi_airway_basal\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	LRIG3 BMPR1B CROT PTPN14	8.19e-05	197	52	4	107cb153ea7fc74bbd244dbb9d0499c0a8506724
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW08-Neuronal-Intermediate\|GW08 / Sample Type, Dataset, Time_group, and Cell type.	CACNG7 PDGFRA ECEL1 HESX1	8.68e-05	200	52	4	401d50fa394fa863fa7836344110ae5c7af3250a
ToppCell	Substantia_nigra-Macroglia-POLYDENDROCYTE-P3-Tnr-Polydendrocyte.Tnr.Cspg5_(Cspg5)\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	PDGFRA STK33 AGBL2	1.59e-04	90	52	3	3817a5b0235e632d976ea565175bdbebbd959bf0
ToppCell	Substantia_nigra-Macroglia-POLYDENDROCYTE-P3-Tnr-Polydendrocyte.Tnr.Cspg5_(Cspg5)-\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	PDGFRA STK33 AGBL2	1.59e-04	90	52	3	a528f5dcee1a356dea89ff2588d2e0f276f2d5fc
Disease	Fetal Mummification	PDGFRA GRHL3	4.55e-05	6	52	2	C2718076
Disease	high altitude adaptation	KNTC1 NEK7	4.07e-04	17	52	2	EFO_0009105
Disease	Ovarian Serous Adenocarcinoma	STK36 NEK7	7.53e-04	23	52	2	C1335177
Disease	pallidum volume	DLG2 HAL	8.90e-04	25	52	2	EFO_0006933
Disease	macrophage inflammatory protein 1b measurement	LRIG3 MYO19 DUSP14	1.79e-03	136	52	3	EFO_0008219
Disease	Cocaine Dependence	PER2 FDFT1 GRM5	1.91e-03	139	52	3	C0600427
Disease	gait measurement	KNTC1 AGBL2 PGF	2.37e-03	150	52	3	EFO_0007680
Disease	total hip arthroplasty, osteoarthritis	LRIG3 COLGALT2	2.51e-03	42	52	2	EFO_0009806, MONDO_0005178
Disease	ejection fraction measurement	FDFT1 CADPS2	2.63e-03	43	52	2	EFO_0005527
Disease	heart rate variability measurement, response to antipsychotic drug	ECEL1 COLGALT2	3.00e-03	46	52	2	EFO_0008003, GO_0097332
Disease	Gastrointestinal Stromal Sarcoma	STK36 PDGFRA	3.13e-03	47	52	2	C3179349
Disease	attention deficit hyperactivity disorder	BMPR1B TLL2 CADPS2 GRM5	3.50e-03	354	52	4	EFO_0003888

Protein segments in the cluster

Peptide	Gene	Start	Entry
YDMPEDSDTYLHRVA	DDX39A	361	O00148
VPDVYEKESRHLMPY	DUSP14	181	O95147
PYHDLVPSDPSYEDM	BMPR1B	426	O00238
LPYPDLETYTVDMSH	AMPD3	246	Q01432
SEEPVHDRYRPTIEM	OPALIN	111	Q96PE5
HEEISDFYEYMSPRP	TENT4B	121	Q8NDF8
SPDGHEYIYVDPMQL	PDGFRA	566	P16234
RTEPSEIMPHIYNYL	nan	901	O00370
AEESYLYKHDIIMPP	HAUS2	206	Q9NVX0
PPDIMHDYPSIREVY	GRM5	716	P41594
MDEYVGLPRDHPESY	GNPDA1	71	P46926
DPRTVLMDHYEPSYI	LRIG3	951	Q6UXM1
VPQLYSPELMREYHA	MYO19	81	Q96H55
TEEYLHPDMYERAVL	IKBKE	176	Q14164
YMEEIYHRIPDSDPS	FDFT1	341	P37268
ENEIRYHPFRMTPYL	PER2	281	O15055
PISHEYYDPAEFMEG	PDZD4	101	Q76G19
LVGTPYYMSPERIHE	NEK7	196	Q8TDX7
RYHRPDQDPEVSEEM	CSPP1	316	Q1MSJ5
DHPMPEERASKYENY	HESX1	76	Q9UBX0
SPPVDLEYQYMLEHV	KNTC1	1566	P50748
YPDSYESMSEPPIAH	TUBGCP6	1431	Q96RT7
MEPPYSLTAHYDEFQ	ECEL1	1	O95672
MATEEFIIRIPPYHY	MVP	1	Q14764
MARRYDELPHYPSIA	MEIS3P2	1	A8K0S8
EMAEDYPRYPDIHDL	CLCN6	776	P51797
AAPYIEKYRMEHIPE	HAL	616	P42357
YHGMEYETDLTPLES	GRHL3	91	Q8TE85
QTIPDPYEDFMYRHL	AGBL2	11	Q5U5Z8
MQLEGYTVDYTDPHP	CADPS2	536	Q86UW7
TKRYAEEEMYRPHPA	CACNG7	201	P62955
MDEYVGLPRNHPESY	GNPDA2	71	Q8TDQ7
RYSPIPKHMLVDDDY	DLG2	326	Q15700
RLYHYVEWRPMDEPE	COLGALT2	111	Q8IYK4
EDFSLPAYMDRRDHP	COX4I1	31	P13073
IERPDLMIYEPHFTY	DMTN	56	Q08495
YSMEDSSPHVTPEDY	CROT	276	Q9UKG9
TPIYMAPEVISAHDY	STK33	286	Q9BYT3
THPEYNSREYMSPDI	OVCH1	126	Q7RTY7
LEHEGEYYMTPRDFL	MICU2	96	Q8IYU8
SQPEMRERHPYTVPY	PTPN14	486	Q15678
PMYSYDPAEELHEAE	SMIM29	56	Q86T20
VELPLTHPEYYEEMG	PSMC1	201	P62191
YMSPELVEERPYDHT	STK36	166	Q9NRP7
EALMEHLVPTVDYYP	RASGEF1A	51	Q8N9B8
RPHSAPEYEDETMTV	ELAC2	166	Q9BQ52
VVSEYPSEVEHMFSP	PGF	61	P49763
LMTLPHFISEPYRYD	SLCO2B1	131	O94956
YDHLEMYDGPDSLAP	TLL2	831	Q9Y6L7
AEDHVESYRTMPIYP	ZNFX1	326	Q9P2E3
MPIYPTYNEVHLDER	ZNFX1	336	Q9P2E3
RHEMVTEPPVVYSYF	ZNF98	76	A6NK75
TEYIADYLMQESPPH	TOPBP1	1466	Q92547
TEEYLHPDMYERAVL	TBK1	176	Q9UHD2