Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionserine-type endopeptidase activity

TMPRSS4 TMPRSS15 TPSG1 CFI PRSS38 KLK1 TMPRSS6 PRSS21

7.82e-11190268GO:0004252
GeneOntologyMolecularFunctionserine-type peptidase activity

TMPRSS4 TMPRSS15 TPSG1 CFI PRSS38 KLK1 TMPRSS6 PRSS21

1.55e-10207268GO:0008236
GeneOntologyMolecularFunctionserine hydrolase activity

TMPRSS4 TMPRSS15 TPSG1 CFI PRSS38 KLK1 TMPRSS6 PRSS21

1.88e-10212268GO:0017171
GeneOntologyMolecularFunctionendopeptidase activity

TMPRSS4 TMPRSS15 TPSG1 CFI PRSS38 KLK1 TMPRSS6 PRSS21

4.82e-08430268GO:0004175
GeneOntologyMolecularFunctionpeptidase activity

TMPRSS4 TMPRSS15 TPSG1 CFI RNPEP PRSS38 KLK1 TMPRSS6 PRSS21

7.79e-08654269GO:0008233
GeneOntologyCellularComponentjunctional membrane complex

JPH4 RYR3

5.33e-059262GO:0030314
GeneOntologyCellularComponentsarcoplasmic reticulum membrane

JPH4 RYR3

1.43e-0345262GO:0033017
GeneOntologyCellularComponentsmooth endoplasmic reticulum

JPH4 RYR3

1.49e-0346262GO:0005790
DomainTRYPSIN_HIS

TMPRSS4 TMPRSS15 TPSG1 CFI PRSS38 KLK1 TMPRSS6 PRSS21

9.34e-13103268IPR018114
DomainTRYPSIN_SER

TMPRSS4 TMPRSS15 TPSG1 CFI PRSS38 KLK1 TMPRSS6 PRSS21

1.18e-12106268PS00135
DomainTRYPSIN_HIS

TMPRSS4 TMPRSS15 TPSG1 CFI PRSS38 KLK1 TMPRSS6 PRSS21

1.28e-12107268PS00134
DomainPeptidase_S1A

TMPRSS4 TMPRSS15 TPSG1 CFI PRSS38 KLK1 TMPRSS6 PRSS21

1.99e-12113268IPR001314
DomainTRYPSIN_DOM

TMPRSS4 TMPRSS15 TPSG1 CFI PRSS38 KLK1 TMPRSS6 PRSS21

2.30e-12115268PS50240
DomainTryp_SPc

TMPRSS4 TMPRSS15 TPSG1 CFI PRSS38 KLK1 TMPRSS6 PRSS21

2.65e-12117268SM00020
DomainTrypsin

TMPRSS4 TMPRSS15 TPSG1 CFI PRSS38 KLK1 TMPRSS6 PRSS21

3.48e-12121268PF00089
DomainTrypsin_dom

TMPRSS4 TMPRSS15 TPSG1 CFI PRSS38 KLK1 TMPRSS6 PRSS21

3.48e-12121268IPR001254
DomainPeptidase_S1_PA

TMPRSS4 TMPRSS15 TPSG1 CFI PRSS38 KLK1 TMPRSS6 PRSS21

3.98e-12123268IPR009003
DomainTRYPSIN_SER

TMPRSS4 TMPRSS15 CFI PRSS38 KLK1 TMPRSS6 PRSS21

2.90e-1190267IPR033116
DomainLdl_recept_a

TMPRSS4 TMPRSS15 CFI TMPRSS6

4.23e-0745264PF00057
Domain-

TMPRSS4 TMPRSS15 CFI TMPRSS6

4.63e-07462644.10.400.10
DomainLDLRA_1

TMPRSS4 TMPRSS15 CFI TMPRSS6

5.51e-0748264PS01209
DomainLDrepeatLR_classA_rpt

TMPRSS4 TMPRSS15 CFI TMPRSS6

5.99e-0749264IPR002172
DomainLDLa

TMPRSS4 TMPRSS15 CFI TMPRSS6

5.99e-0749264SM00192
DomainLDLRA_2

TMPRSS4 TMPRSS15 CFI TMPRSS6

5.99e-0749264PS50068
DomainCUB_dom

TMPRSS15 MGAT3 TMPRSS6 SEZ6

1.11e-0657264IPR000859
DomainSR

TMPRSS4 TMPRSS15 CFI

5.40e-0625263SM00202
Domain-

TMPRSS4 TMPRSS15 CFI

5.40e-06252633.10.250.10
DomainSRCR_1

TMPRSS4 TMPRSS15 CFI

6.10e-0626263PS00420
DomainSRCR-like_dom

TMPRSS4 TMPRSS15 CFI

6.10e-0626263IPR017448
DomainSRCR_2

TMPRSS4 TMPRSS15 CFI

6.10e-0626263PS50287
DomainSRCR

TMPRSS4 TMPRSS15 CFI

6.85e-0627263IPR001190
DomainSRCR_2

TMPRSS4 TMPRSS15

3.90e-057262PF15494
DomainCUB

TMPRSS15 TMPRSS6 SEZ6

4.49e-0550263SM00042
Domain-

TMPRSS15 TMPRSS6 SEZ6

5.06e-05522632.60.120.290
DomainCUB

TMPRSS15 TMPRSS6 SEZ6

5.36e-0553263PS01180
Domain-

TMPRSS15 TMPRSS6

1.93e-04152623.30.70.960
DomainSRCR

TMPRSS15 CFI

3.85e-0421262PF00530
DomainSEA

TMPRSS15 TMPRSS6

4.23e-0422262PF01390
DomainSEA

TMPRSS15 TMPRSS6

4.63e-0423262PS50024
DomainSEA_dom

TMPRSS15 TMPRSS6

4.63e-0423262IPR000082
DomainLDLR_class-A_CS

TMPRSS15 CFI

1.41e-0340262IPR023415
DomainCUB

TMPRSS15 SEZ6

2.11e-0349262PF00431
Pubmed

Mouse chromosome 17A3.3 contains 13 genes that encode functional tryptic-like serine proteases with distinct tissue and cell expression patterns.

TPSG1 PRSS21

2.41e-051026214583634
Pubmed

New molecular components supporting ryanodine receptor-mediated Ca(2+) release: roles of junctophilin and TRIC channel in embryonic cardiomyocytes.

JPH4 RYR3

3.53e-051226219095005
Pubmed

Novel loci affecting iron homeostasis and their effects in individuals at risk for hemochromatosis.

TEX14 TMPRSS6

3.53e-051226225352340
Pubmed

Phenotypic analysis of mice lacking the Tmprss2-encoded protease.

TMPRSS4 TMPRSS6

3.53e-051226216428450
Pubmed

Target-derived BMP signaling limits sensory neuron number and the extent of peripheral innervation in vivo.

NOG KLK1

4.17e-051326214973275
Pubmed

Regulation of cell surface protease matriptase by HAI2 is essential for placental development, neural tube closure and embryonic survival in mice.

TMPRSS4 KLK1

1.12e-042126219592578
Pubmed

The ets-domain transcription factor Spdef promotes maturation of goblet and paneth cells in the intestinal epithelium.

TPSG1 KLK1

1.35e-042326219549527
Pubmed

Inactivation of the microRNA-183/96/182 cluster results in syndromic retinal degeneration.

CFI SLC25A15 SEZ6

6.22e-0422526323341629
InteractionTMPRSS7 interactions

TMPRSS4 TMPRSS6

4.46e-058262int:TMPRSS7
InteractionTPSG1 interactions

TPSG1 PRSS21

4.46e-058262int:TPSG1
InteractionTMPRSS6 interactions

TMPRSS4 TMPRSS6

7.16e-0510262int:TMPRSS6
InteractionCORIN interactions

TMPRSS4 TMPRSS6

1.05e-0412262int:CORIN
Cytoband17q22

NOG TEX14

2.88e-044426217q22
Cytoband16p13.3

OR2C1 TPSG1 PRSS21

3.52e-0424426316p13.3
CytobandEnsembl 112 genes in cytogenetic band chr17q22

NOG TEX14

1.15e-0388262chr17q22
CytobandEnsembl 112 genes in cytogenetic band chr16p13

OR2C1 TPSG1 PRSS21

1.76e-03426263chr16p13
GeneFamilyProteases, serine

TMPRSS4 TMPRSS15 TPSG1 PRSS38 TMPRSS6 PRSS21

3.67e-1163196738
ToppCellAT1-AT2_cells-Cryobiopsy_01|World / lung cells shred on cell class, cell subclass, sample id

TMPRSS4 CRYBG2 IGSF1 CFI TMPRSS6

4.75e-081722650be41df5d35d818deb7316ac21c9366eb4b7bfd1
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-3_VIP_ZNF322P1|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

THSD7A KLK1 RYR3 SEZ6

3.31e-061782642a36475c260088f69f3b8c282d910e5eaa5c5c2d
ToppCellE18.5-samps-Epithelial-Epithelial-non_alveolar-Club_cell|E18.5-samps / Age Group, Lineage, Cell class and subclass

MGAT3 IGSF1 TMPRSS6

8.75e-0514926382edfecb7981d8c336cf9da7aa7e2b3f7a017a3f
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Lect1_Oxtr|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

THSD7A RYR3 SEZ6

8.75e-0514926310ffd0051fb027bbebc662ca602c80d89bbf99c6
ToppCellE18.5-samps-Epithelial-Epithelial-non_alveolar|E18.5-samps / Age Group, Lineage, Cell class and subclass

MGAT3 IGSF1 TMPRSS6

8.75e-0514926314a01ae540db8a350ea26a350b2e6ce6c07639d9
ToppCelldroplet-Liver-nan-3m-Epithelial-Hepatocyte_(Pericentral,_Midlobular,_Periportal)|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CFI TMPRSS6 SLC25A15

9.10e-05151263cc9632b58522e2ba3ad36a0b8d37c7c9c8b636c4
ToppCellTransplant_Alveoli_and_parenchyma-Epithelial-Basal_2|Transplant_Alveoli_and_parenchyma / Tissue, Lineage and Cell class of Lung Cells from 10X

TMPRSS4 CRYBG2 TMPRSS6

9.47e-05153263a44da11a913b19edde6c5d1d6e625c24b20ecbfd
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Lect1_Oxtr|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

THSD7A RYR3 SEZ6

9.84e-0515526399e749f7075e2c64e9a0bf91009f95b6969197c8
ToppCell10x5'-bone_marrow-Mast|bone_marrow / Manually curated celltypes from each tissue

THSD7A TPSG1 RYR3

1.06e-04159263c3d3570e83c5d25cc92fa3a7a8f0dc2f89a72913
ToppCellfacs-Marrow-Granulocytes-3m-Lymphocytic-NK_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

JPH4 SLC20A1 TMPRSS6

1.06e-04159263d2de9391b00b6c47f5fe28a1bad6da2097107ee0
ToppCellfacs-Marrow-Granulocytes-3m-Lymphocytic-NK_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

JPH4 SLC20A1 TMPRSS6

1.06e-04159263da6b7f8039adc19839d6c090a0b3d68fb6445a79
ToppCelldroplet-Liver-Hepatocytes-18m-Epithelial-Hepatocyte_(Pericentral,_Midlobular,_Periportal)|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CFI TMPRSS6 SLC25A15

1.08e-041602638de1fc75241d9bf2b355afa0e9ef39fea1977177
ToppCellTransplant_Alveoli_and_parenchyma-Epithelial-Basal_2|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X

TMPRSS4 CRYBG2 TMPRSS6

1.14e-04163263f21951e63188eb0c04675a8f81a0da495c26c007
ToppCelldroplet-Liver-Hepatocytes-18m-Epithelial-hepatocyte|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CFI TMPRSS6 SLC25A15

1.14e-0416326303d9fa615d9d02ef98e20f28a10aaa6894dd4960
ToppCelldroplet-Liver-Hepatocytes-18m|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CFI TMPRSS6 SLC25A15

1.14e-041632637e82c1b7849eca895732df2da74ac6430bd9ba7a
ToppCelldroplet-Liver-Hepatocytes-18m-Epithelial|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CFI TMPRSS6 SLC25A15

1.14e-041632631c4de36cf8cdaabb981cda5c7ce7e5ae7b4280e3
ToppCelldroplet-Liver-HEPATOCYTES-1m-Epithelial-Hepatocyte_(Pericentral_and_Periportal)|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CFI TMPRSS6 SLC25A15

1.18e-04165263d449a568664a81d9b5538e8f409301448a32ac37
ToppCellBasal_cells-Donor_07|World / lung cells shred on cell class, cell subclass, sample id

TMPRSS4 CRYBG2 TPSG1

1.20e-04166263aea2ae12e4746149ebc6da063ef694381c098f80
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_2-Inh_L1-6_PVALB_SCUBE3_(Chandelier_1)|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

NOG THSD7A SEZ6

1.32e-04171263ff4ab7753320874600e5694f2681e672c144c294
ToppCell5'-GW_trimst-1.5-LargeIntestine-Epithelial-Tuft-related|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TMPRSS4 KLK1 TMPRSS6

1.32e-04171263042701dd87676d41d8e7e7cce0e1ffc2331b248d
ToppCell5'-GW_trimst-1.5-LargeIntestine-Epithelial-Tuft-related-BEST4+_epithelial|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TMPRSS4 KLK1 TMPRSS6

1.32e-0417126374d7811a57837d99932a9b86f2d08e8574a819e6
ToppCell3'_v3-blood-Mast|blood / Manually curated celltypes from each tissue

TPSG1 RYR3 PRSS21

1.34e-04172263e7a46bbeff749ca59b9f1357409ce1ad59dd22dd
ToppCellfacs-Aorta-Heart-24m-Epithelial|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TMPRSS4 TPSG1 KLK1

1.36e-0417326386aa15cf5c450465290de1c3dd9ff9d355d9cbee
ToppCellfacs-Aorta-Heart-24m-Epithelial-epithelial_cell|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TMPRSS4 TPSG1 KLK1

1.36e-041732632216e36c77cb3b531508f897c1e7e01b94037d5e
ToppCellfacs-Aorta-Heart-24m-Epithelial-nan|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TMPRSS4 TPSG1 KLK1

1.36e-04173263a3a09fe5cdb9e91e0880e247bf8d974fe29c6fa8
ToppCell10x5'-blood-Mast-Mast_cells|blood / Manually curated celltypes from each tissue

MGAT3 THSD7A RYR3

1.38e-04174263a5838821bba2be790d32331ff529d466e9974268
ToppCellfacs-Large_Intestine-Distal-18m-Epithelial-nan|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TPSG1 KLK1 SLC20A1

1.38e-04174263d927504d27b07bbc580bf57c60b383bd28624652
ToppCell10x5'-blood-Mast|blood / Manually curated celltypes from each tissue

MGAT3 THSD7A RYR3

1.38e-041742633a8a253213b207e3ff56f94a74996b8d9ad47aa1
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-3_VIP_ZNF322P1|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

THSD7A RYR3 SEZ6

1.41e-041752639d09636a103daa8f622c3dbfd1f1536aaec3b6bb
ToppCell5'-GW_trimst-1.5-LargeIntestine-Epithelial-mature_enterocytic-Enterocyte|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TMPRSS4 IGSF1 KLK1

1.43e-0417626324eedbbb406d788630bb16678cceef4492d3999c
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-3_VIP_GGH|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

THSD7A KLK1 SEZ6

1.43e-0417626323f930dac5247ea6d4124da33933d61ad6e089af
ToppCelldroplet-Kidney-nan-21m|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CFI KLK1 TMPRSS6

1.43e-041762630475db3f860de1e216cbdeb886f7a75b9f4fc801
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-3_VIP_GGH|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

THSD7A KLK1 SEZ6

1.46e-04177263d7976eac7e27044f6a859cc0c3398d08576e8c01
ToppCell3'_v3-bone_marrow-Mast|bone_marrow / Manually curated celltypes from each tissue

THSD7A TPSG1 RYR3

1.53e-04180263b37ee81b792213d6595b4ec65d04bc35d83321c7
ToppCellfacs-Large_Intestine-Distal-3m-Epithelial-nan|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TPSG1 KLK1 SLC20A1

1.53e-04180263a0faed4cf23f6d5e6e8f6b0284cea8a5bd0680a0
ToppCell3'_v3-bone_marrow-Mast-Mast_cells|bone_marrow / Manually curated celltypes from each tissue

THSD7A TPSG1 RYR3

1.56e-0418126330ec4635474ee0f0ea1415ec0ba7f008d97e8c1a
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-3_VIP_ZNF322P1|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

THSD7A RYR3 SEZ6

1.56e-04181263062f00736eed96e4f4327615d093558dd7d82b20
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L3_VIP_CBLN1|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

THSD7A RYR3 SEZ6

1.56e-041812637846c7b33d1b89364c5a704edaa86520db731c89
ToppCellfacs-Brain_Non-Myeloid-Cortex-3m-Neuronal-medium_spiny_neuron|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TMPRSS6 RYR3 SEZ6

1.58e-04182263d41ff834b8fc1d0e23cac7ae261de5f72874e462
ToppCellfacs-Brain_Non-Myeloid-Cortex-3m-Neuronal-SPN_Neuron_STR|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TMPRSS6 RYR3 SEZ6

1.58e-041822636cde859edfe7607bd7ada89d20258413d06f4207
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-3_VIP_ZNF322P1|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

THSD7A RYR3 SEZ6

1.58e-04182263d3a037268f026eb2f84428b1821022503cef7756
ToppCellfacs-Kidney-nan-24m-Epithelial-kidney_loop_of_Henle_ascending_limb_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TMPRSS4 KLK1 TMPRSS6

1.58e-04182263b8be66a867ea1bbae0820b26dbd55b68611f5ad5
ToppCellfacs-Kidney-nan-24m-Epithelial-kidney_loop_of_Henle_ascending_limb_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TMPRSS4 KLK1 TMPRSS6

1.58e-04182263cb488f9a9b200e2557335ccf22535cd247512cdc
ToppCelldroplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Endothelial-leukocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NOG THSD7A RYR3

1.61e-04183263919c9861073d12fd12aecd7469b1478b13838c43
ToppCelldroplet-Kidney-nan-21m-Epithelial-kidney_proximal_convoluted_tubule_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MGAT3 CFI SLC25A15

1.63e-0418426345577ff91c3b2b303acd97239dde2463ea7a429c
ToppCelldroplet-Kidney-nan-21m-Epithelial-Epcam____kidney_proximal_convoluted_tubule_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MGAT3 CFI SLC25A15

1.63e-041842633d7dd193a0826cc7a4e454a29236a16c315e5965
ToppCell367C-Endothelial_cells-Endothelial-B_(Artery)-|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)

NOG TEX14 THSD7A

1.66e-04185263b57dae20c21f984edd2acee4344d86f033108ebf
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-3_VIP_ZNF322P1|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

THSD7A RYR3 SEZ6

1.66e-041852630b5a0df58ae2ad8261f40f152775747af4f3937a
ToppCell367C-Endothelial_cells-Endothelial-B_(Artery)|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)

NOG TEX14 THSD7A

1.66e-04185263d3b054d203e575c1bb5455aa7a2e551a0957a760
ToppCellfacs-Skin-Anagen-3m-Epithelial-nan|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TMPRSS4 CRYBG2 RNPEP

1.69e-041862639a7932d0a208f3997216bd21a72913cc82b59fc9
ToppCell5'-GW_trimst-1.5-LargeIntestine-Epithelial-mature_enterocytic-Colonocyte|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TMPRSS4 IGSF1 KLK1

1.71e-041872631909b65ba23d598e396f77eecae562bb59bf5d5d
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-3_VIP_GGH|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

THSD7A KLK1 SEZ6

1.71e-04187263eb011a3d8a3025cebb0fba36d403be906305372c
ToppCell5'-Adult-SmallIntestine-Epithelial-goblet-Goblet_cell|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TMPRSS4 TPSG1 KLK1

1.74e-0418826391fa9cc29cbc88d3c29590ecee5c8ce858ac0aa7
ToppCellfacs-Heart-RA-24m-Mesenchymal|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IGSF1 TMPRSS6 RYR3

1.77e-04189263e4efbb0733b382f4c855f6653dcddf36e0f8df28
ToppCell5'-Adult-SmallIntestine-Epithelial-goblet|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TMPRSS4 TPSG1 KLK1

1.77e-041892636f4f2911fcbf3b43718b6183dbd9c970d4c19607
ToppCell5'-GW_trimst-1.5-LargeIntestine-Epithelial-mature_enterocytic|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TMPRSS4 IGSF1 KLK1

1.77e-041892638478f433495dabe813146a1f6b00098db8ce775a
ToppCellfacs-Kidney-nan-3m-Epithelial-kidney_loop_of_Henle_ascending_limb_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KLK1 TMPRSS6 SEZ6

1.79e-0419026368ba1934b2b3f0cec8efd229fe1db6e8be8a26b0
ToppCellfacs-Kidney-nan-3m-Epithelial-kidney_loop_of_Henle_ascending_limb_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KLK1 TMPRSS6 SEZ6

1.79e-04190263010d7d13a3c16e614c36720ef690a505b9f3f7aa
ToppCelldroplet-Kidney-nan-18m-Epithelial-Epcam_____kidney_distal_convoluted_tubule_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NOG KLK1 TMPRSS6

1.85e-041922636fb56d062c35617b18b927704bf5fba894faed81
ToppCellfacs-Brain_Non-Myeloid-Striatum|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

THSD7A RYR3 SEZ6

1.88e-04193263d8ccfb780a75bdf9141f41fb29a076958601ebb4
ToppCelldroplet-Kidney-nan-21m-Epithelial-Epcam_____kidney_distal_convoluted_tubule_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NOG KLK1 TMPRSS6

1.88e-04193263b397c14ac1e34c6be3f25d4417d200bc518d3048
ToppCelldroplet-Kidney-nan-21m-Epithelial-kidney_distal_convoluted_tubule_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NOG KLK1 TMPRSS6

1.88e-04193263241a60d1f0d5832638fb3e1e4b7afa7387ea3c75
ToppCelldroplet-Kidney-nan-18m-Epithelial-kidney_distal_convoluted_tubule_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NOG KLK1 TMPRSS6

1.88e-04193263fa8bcf2a5ab7b08fae98a1466a936995142b4309
ToppCellfacs-Brain_Non-Myeloid-Striatum-3m|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

THSD7A RYR3 SEZ6

1.91e-04194263ba529c051f248d29f4222f4bc9801ba233859093
ToppCellTCGA-Thryoid-Primary_Tumor-Thyroid_Papillary_Carcinoma-Classical|TCGA-Thryoid / Sample_Type by Project: Shred V9

MGAT3 CFI TMPRSS6

1.91e-04194263b46c54802b8d1e0a0a17f9ed8e82eaf5e7f4849d
ToppCellproximal-Hematologic-Natural_Killer_T-3|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

TEP1 SLC25A15 SEZ6

1.94e-041952634d7c2c4d0130c2d46877ff6dd4584525d8f74daf
ToppCellproximal-3-Hematologic-Natural_Killer_T|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

TEP1 SLC25A15 SEZ6

1.94e-0419526393093545bb23d2619ace029a52cffa1f673a0c2a
ToppCellproximal-Hematologic-Natural_Killer_T|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

TEP1 SLC25A15 SEZ6

1.94e-041952633944e4800f5d904d4efa401ce8913ec0e0781211
ToppCell5'-GW_trimst-2-LargeIntestine-Epithelial|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TMPRSS4 TPSG1 KLK1

1.97e-0419626379bc7ab96b52b2a542348a13ddd0a4f095698c5e
ToppCell5'-Adult-LargeIntestine-Endothelial-blood_vessel_EC-Mature_venous_EC|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

THSD7A CFI RYR3

2.00e-0419726387eda06344498dc66cac292cf89746dc90b5cf67
ToppCellBrain_organoid-organoid_Kanton_Nature-Organoid-2M-Neuronal-cortical_neurons_1|Organoid-2M / Sample Type, Dataset, Time_group, and Cell type.

JPH4 THSD7A SEZ6

2.03e-04198263d81f35c0066558ff96dd06f58fca72cd82e681e8
ToppCellControl_saline-Epithelial_airway-airway_epithelial-Airway-Club|Control_saline / Treatment groups by lineage, cell group, cell type

TMPRSS4 CRYBG2 IGSF1

2.06e-041992635cc8b553a58669a30eb10845beb23983dcdf5a6a
ToppCellTracheal-10x5prime-Stromal-Schwann-Schwann_Myelinating|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

MGAT3 NOG IGSF1

2.06e-041992632b567b6fd8addf059bbf2b72c55a7647aefdc595
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW09-Neuronal|GW09 / Sample Type, Dataset, Time_group, and Cell type.

JPH4 THSD7A SEZ6

2.09e-04200263e9eb348a66011d8aace4331f84690ae27cb0d061
ToppCellBrain_organoid-organoid_Tanaka_cellReport-3m|organoid_Tanaka_cellReport / Sample Type, Dataset, Time_group, and Cell type.

JPH4 THSD7A SEZ6

2.09e-04200263e4f0bb57be1112869c7068d0a789c2b802a442dd
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW09-Neuronal-Neurons|GW09 / Sample Type, Dataset, Time_group, and Cell type.

JPH4 THSD7A SEZ6

2.09e-04200263ddac952ad1d46021c2d17d816de9bc31730a0941
ToppCellNeuronal-Inhibitory-iA-iA_3(VIP)-VIP_3-CBLN1-L2-4|Neuronal / cells hierarchy compared to all cells using T-Statistic

THSD7A RYR3 SEZ6

2.09e-042002632086024ce808b8796ed508a229b098eb02f8828a
ToppCellBrain_organoid-organoid_Tanaka_cellReport-2m-Neuronal|2m / Sample Type, Dataset, Time_group, and Cell type.

JPH4 THSD7A SEZ6

2.09e-0420026360b86c4a4e247b2673d31b085b440a6e574393bb
ToppCellBrain_organoid-organoid_Tanaka_cellReport-2m-Neuronal-Cortical_neuron|2m / Sample Type, Dataset, Time_group, and Cell type.

JPH4 THSD7A SEZ6

2.09e-04200263db2dbd31dd02c0d1c1070ed5548ce949227e4775
ToppCellNeuronal-Inhibitory-iA-iA_3(VIP)-VIP_3-CHRM2|Neuronal / cells hierarchy compared to all cells using T-Statistic

THSD7A RYR3 SEZ6

2.09e-04200263501a3b93624df463458a35d3e6648d4ccc941724
ToppCellBrain_organoid-organoid_Tanaka_cellReport-3m-Neuronal-Cortical_neuron|3m / Sample Type, Dataset, Time_group, and Cell type.

JPH4 THSD7A SEZ6

2.09e-04200263c248233b004f8ef0bab3c65ecfe295887966f2ee
ToppCellNeuronal-Inhibitory-iA-iA_3(VIP)-VIP_3-CHRM2-L1-3|Neuronal / cells hierarchy compared to all cells using T-Statistic

THSD7A RYR3 SEZ6

2.09e-04200263d1f36a8232411933b1494168ec912fd0e5246428
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW09-Neuronal-Cortical_neuron|GW09 / Sample Type, Dataset, Time_group, and Cell type.

JPH4 THSD7A SEZ6

2.09e-0420026344bc4d6616fc8d0ad8498e56125939034e8cff01
ToppCellBrain_organoid-organoid_Tanaka_cellReport-3m-Neuronal|3m / Sample Type, Dataset, Time_group, and Cell type.

JPH4 THSD7A SEZ6

2.09e-04200263af99d90070e2933fd2e9512590c6cf3bd6e15539
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW09-Neuronal|GW09 / Sample Type, Dataset, Time_group, and Cell type.

JPH4 THSD7A SEZ6

2.09e-0420026309fd3cb31bcc02444f1045f01fe39bce09359d35
ToppCellNeuronal-Inhibitory-iA-iA_3(VIP)-VIP_3-CBLN1|Neuronal / cells hierarchy compared to all cells using T-Statistic

THSD7A RYR3 SEZ6

2.09e-0420026335951db6a4f442ac9e13f1b8cc5b4a33481f92c8
ToppCellSubstantia_nigra-Macroglia-OLIGODENDROCYTE-O2-Tfr-Oligodendrocyte.Tfr.Ndrg2_(Ndrg2)|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

CRYBG2 CLRN2

5.94e-046226219867e62ca7e024572192a2654e2eb8f226bdd60
ToppCellSubstantia_nigra-Macroglia-OLIGODENDROCYTE-O2-Tfr-Oligodendrocyte.Tfr.Ndrg2_(Ndrg2)-|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

CRYBG2 CLRN2

5.94e-0462262f7697057fb5568368ec7edead2bcdd25ede7627b
ToppCellThalamus-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Slc17a6-Rora-Excitatory_Neuron.Slc17a6.Rora.Cbln2_(Neuron.Slc17a6.Rora.Cbln2)|Thalamus / BrainAtlas - Mouse McCarroll V32

TMPRSS4 KLK1

6.94e-04672625202166895fd109ad0d7584fc35c74814a59ce2b
ToppCellFrontal_cortex-Neuronal-Inhibitory-iN2(Gad1Gad2)-Synpr-Inhibitory_Neuron.Gad1Gad2.Synpr-Crispld2_(Neuron.Gad1Gad2.Synpr-Crispld2)-|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

TMPRSS4 CLRN2

6.94e-0467262f117cec517d15bff2d4b963c5791877426272631
ToppCellFrontal_cortex-Neuronal-Inhibitory-iN2(Gad1Gad2)-Synpr-Inhibitory_Neuron.Gad1Gad2.Synpr-Crispld2_(Neuron.Gad1Gad2.Synpr-Crispld2)|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

TMPRSS4 CLRN2

6.94e-0467262df06046269894edbc872b48b9eccb458f6be8cf2
ToppCellHippocampus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Sfrp2-Inhibitory_Neuron.Gad1Gad2_Id2.Sfrp2_(Interneuron,_Neurogliaform1)|Hippocampus / BrainAtlas - Mouse McCarroll V32

TEX14 CLRN2

8.23e-0473262cc89c94a3768b02036757dea86989d9284b214b9
ToppCellHippocampus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Sfrp2|Hippocampus / BrainAtlas - Mouse McCarroll V32

TEX14 CLRN2

8.23e-04732626f28d52700bab981c8a3664ba4762f3572f7e788
ToppCellHippocampus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Sfrp2-Inhibitory_Neuron.Gad1Gad2_Id2.Sfrp2_(Interneuron,_Neurogliaform1)-|Hippocampus / BrainAtlas - Mouse McCarroll V32

TEX14 CLRN2

8.23e-0473262ae80fcf3544c18fe0318a8311e96f2448f7cb03c
ToppCellEntopeduncular-Macroglia-OLIGODENDROCYTE-O1-Trf|Entopeduncular / BrainAtlas - Mouse McCarroll V32

CRYBG2 CLRN2

8.91e-0476262efbbbf91bca35720d8ecddb076f2c9f4de25e44d
ToppCellEntopeduncular-Macroglia-OLIGODENDROCYTE-O1|Entopeduncular / BrainAtlas - Mouse McCarroll V32

CRYBG2 CLRN2

8.91e-0476262254d18bece2676faa4bbeb8d48b1d327ab3c2215
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW12-Neuronal-Cortical_neuron|GW12 / Sample Type, Dataset, Time_group, and Cell type.

JPH4 THSD7A

1.36e-0394262a752c80fb2e83cffa22a00d7e98c24406ee41908
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Serpinf1-Serpinf1_Aqp5_Vip|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

PRSS38 TMPRSS6

1.89e-0311126284b7d4fe5839f649bc4246738d620c9cee3c4cf7
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Serpinf1|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

PRSS38 TMPRSS6

2.16e-031192629ffdb432ec06d12eccbc9af9d30c0d24a0a21030
ToppCellLPS-IL1RA+antiTNF-Epithelial_alveolar-AT_1-Airway|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

JPH4 PRSS21

2.35e-03124262a7b7d8b14d1218194da8fcf69b4780b6e9469332
DrugBAPNA

TMPRSS15 TPSG1 KLK1 RYR3

5.06e-0757264CID000013494
DrugAlaptide

TPSG1 KLK1

1.25e-055262CID000119329
Drugbenzamidine

TMPRSS15 TPSG1 KLK1 PRSS21

2.23e-05147264CID000002332
DrugTLCK

TMPRSS15 TPSG1 RNPEP KLK1

2.96e-05158264CID000004427
DrugAC1Q6PMP

TMPRSS15 TPSG1 RNPEP KLK1

3.86e-05169264CID000103535
Drug7-amino-4-methylcoumarin

TMPRSS15 RNPEP KLK1

4.12e-0559263CID000092249
DrugBAEE

TMPRSS15 TPSG1 KLK1

5.26e-0564263CID000123880
DrugAPC-366

TPSG1 KLK1

5.61e-0510262CID000177339
DrugN-Acetyl-DL-homocysteine Thiolactone [1195-16-0]; Up 200; 25.2uM; MCF7; HT_HG-U133A

CRYBG2 TMPRSS15 TPSG1 KLK1

6.60e-051942646031_UP
DrugPrimaquine diphosphate [63-45-6]; Up 200; 8.8uM; PC3; HT_HG-U133A

TMPRSS4 IGSF1 RYR3 PRSS21

6.73e-051952644263_UP
DrugTorsemide [56211-40-6]; Up 200; 11.4uM; MCF7; HT_HG-U133A

TMPRSS15 TEX14 TPSG1 TEP1

6.86e-051962643517_UP
DrugIohexol [66108-95-0]; Up 200; 4.8uM; MCF7; HT_HG-U133A

TMPRSS4 MGAT3 TEX14 TPSG1

6.86e-051962645704_UP
Drugp-nitroaniline

TMPRSS15 RNPEP KLK1

6.88e-0570263CID000007475
DrugLidoflazine [3416-26-0]; Up 200; 8.2uM; MCF7; HT_HG-U133A

TMPRSS4 TEP1 TMPRSS6 PRSS21

7.00e-051972643201_UP
DrugDantrolene sodium salt [14663-23-1]; Up 200; 11.8uM; MCF7; HT_HG-U133A

TMPRSS4 MGAT3 TEX14 KLK1

7.00e-051972643867_UP
DrugMetampicillin sodium salt [6489-61-8]; Up 200; 10.4uM; MCF7; HT_HG-U133A

CRYBG2 TMPRSS15 TEX14 TEP1

7.14e-051982642286_UP
DrugTetrahydrozoline hydrochloride [522-48-5]; Up 200; 16.8uM; MCF7; HT_HG-U133A

CRYBG2 MGAT3 TPSG1 TMPRSS6

7.28e-051992646069_UP
DrugSaquinavir mesylate [149845-06-7]; Up 200; 5.2uM; MCF7; HT_HG-U133A

TMPRSS4 CRYBG2 MGAT3 TMPRSS6

7.42e-052002643549_UP
Drug4-amidinophenylpyruvic acid

TPSG1 KLK1

8.22e-0512262CID000151496
Drugnafamostat mesilate

TMPRSS15 TPSG1 KLK1

9.14e-0577263CID000004413
DrugZ-ARR-AFC

TPSG1 KLK1

9.71e-0513262CID000125067
Drug7-amino-4-trifluoromethylcoumarin

TMPRSS15 KLK1

1.13e-0414262CID000100641
Diseaseiron biomarker measurement, ferritin measurement

TEX14 TMPRSS6

1.17e-0419252EFO_0004459, EFO_0004461
Diseaseage at voice drop

IGSF1 THSD7A

1.58e-0422252EFO_0007888
Diseasetotal iron binding capacity

THSD7A TMPRSS6

1.99e-0378252EFO_0006334

Protein segments in the cluster

PeptideGeneStartEntry
SGITCGGIYIGGCWI

CFI

361

P05156
TYRVGEGPGVCWLAP

RNPEP

141

Q9H4A4
DGVLQGVTSWGYVPC

KLK1

221

P06870
GWHGPSCGVPTVVQY

MGAT3

176

Q09327
PGRNCSIAGWGTVVY

TMPRSS15

906

P98073
VGGWEAGRAHGYGVC

JPH4

16

Q96JJ6
VLGRWGNYGPGDCFV

PCNX3

1361

Q9H6A9
WGPGKTISYGGCITQ

OR2C1

86

O95371
GIVSWGRGCSNPLYP

PRSS38

261

A1L453
NVTLWCRGPVHGVGY

IGSF1

986

Q8N6C5
VGSLRVLGGCWVGYE

CRYBG2

1206

Q8N1P7
ACRGQFVPVGGTWVE

MAN2C1

321

Q9NTJ4
PIWLLLYGGVGICVG

SLC20A1

561

Q8WUM9
GGQRCGWIPIQYPII

NOG

211

Q13253
SWGEGCGRPNRPGVY

TPSG1

241

Q9NRR2
RLVYSPSWCGGLVQG

TEX14

171

Q8IWB6
GDGVVPCATYGWRTT

THSD7A

416

Q9UPZ6
GGVGGICLWLAVYPV

SLC25A15

216

Q9Y619
PAGCVWGVAYRLPVG

CHAC2

56

Q8WUX2
VPYRAVSGPGGICLW

CLRN2

126

A0PK11
PCEWGGVAAGRPYVG

TEP1

1076

Q99973
GYFGRTWQPGDVVGC

RYR3

1136

Q15413
VGIVSWGYGCGGPST

TMPRSS4

401

Q9NRS4
EPYGRGQDCIWGVHV

SEZ6

611

Q53EL9
YQIGVVSWGVGCGRP

PRSS21

251

Q9Y6M0
VSWGLGCGRPNYFGV

TMPRSS6

781

Q8IU80