Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	serine hydrolase activity	ACHE APEH KLK3 OVCH1 PRSS36 LPA TMPRSS2 SCPEP1 HABP2 PLG	7.94e-06	212	159	10	GO:0017171
GeneOntologyMolecularFunction	serine-type peptidase activity	APEH KLK3 OVCH1 PRSS36 LPA TMPRSS2 SCPEP1 HABP2 PLG	4.32e-05	207	159	9	GO:0008236
GeneOntologyMolecularFunction	carbon-carbon lyase activity	AZIN2 DDC SGPL1 CSAD HDC	8.27e-05	56	159	5	GO:0016830
GeneOntologyMolecularFunction	serine-type endopeptidase activity	APEH KLK3 OVCH1 PRSS36 LPA TMPRSS2 HABP2 PLG	1.45e-04	190	159	8	GO:0004252
GeneOntologyMolecularFunction	endopeptidase activity	APEH REN KLK3 OVCH1 PRSS36 LPA TMPRSS2 ATG4C ERVK-19 HABP2 ERVK-25 PLG	1.76e-04	430	159	12	GO:0004175
GeneOntologyMolecularFunction	carboxy-lyase activity	AZIN2 DDC CSAD HDC	1.87e-04	36	159	4	GO:0016831
GeneOntologyMolecularFunction	peptidase activity	APEH REN ERMP1 KLK3 OVCH1 PRSS36 AOPEP LPA TMPRSS2 ATG4C ERVK-19 SCPEP1 HABP2 ERVK-25 PLG	2.38e-04	654	159	15	GO:0008233
GeneOntologyMolecularFunction	alpha-1,2-mannosyltransferase activity	PIGZ ALG9	3.74e-04	4	159	2	GO:0000026
GeneOntologyBiologicalProcess	trans-synaptic signaling by BDNF, modulating synaptic transmission	NTRK2 LPA PLG	1.57e-05	7	160	3	GO:0099183
GeneOntologyBiologicalProcess	trans-synaptic signaling by BDNF	NTRK2 LPA PLG	2.49e-05	8	160	3	GO:0099191
GeneOntologyCellularComponent	lumenal side of endoplasmic reticulum membrane	HLA-DRB1 HLA-DRB3 ALG9 TAPBP	1.44e-04	35	160	4	GO:0098553
GeneOntologyCellularComponent	nuclear outer membrane-endoplasmic reticulum membrane network	SLC37A1 ACSL6 NEU4 HLA-DRB1 HLA-DRB3 INSIG1 ERMP1 IRAG1 PIGZ SLC39A13 RYR1 HHATL GDPD5 GUCY2F OSBPL3 SGPL1 ALG9 RAB3GAP2 GUCY2D SIK2 ATP2A2 TAPBP ACSL5	1.98e-04	1327	160	23	GO:0042175
GeneOntologyCellularComponent	autolysosome membrane	HLA-DRB1 HLA-DRB3	3.46e-04	4	160	2	GO:0120281
GeneOntologyCellularComponent	endoplasmic reticulum membrane	SLC37A1 ACSL6 NEU4 HLA-DRB1 HLA-DRB3 INSIG1 ERMP1 IRAG1 PIGZ SLC39A13 RYR1 HHATL GDPD5 OSBPL3 SGPL1 ALG9 RAB3GAP2 GUCY2D SIK2 ATP2A2 TAPBP ACSL5	3.56e-04	1293	160	22	GO:0005789
GeneOntologyCellularComponent	endoplasmic reticulum subcompartment	SLC37A1 ACSL6 NEU4 HLA-DRB1 HLA-DRB3 INSIG1 ERMP1 IRAG1 PIGZ SLC39A13 RYR1 HHATL GDPD5 OSBPL3 SGPL1 ALG9 RAB3GAP2 GUCY2D SIK2 ATP2A2 TAPBP ACSL5	3.79e-04	1299	160	22	GO:0098827
GeneOntologyCellularComponent	side of membrane	EPOR RASGRP4 ACHE HLA-DRB1 HLA-DRB3 CD109 RYR1 BTN2A2 IGHD LPA ALG9 PLG ADGRE1 ATP2A2 IL3RA TAPBP IL27RA	4.01e-04	875	160	17	GO:0098552
GeneOntologyCellularComponent	lumenal side of membrane	HLA-DRB1 HLA-DRB3 ALG9 TAPBP	4.95e-04	48	160	4	GO:0098576
MousePheno	abnormal mammary gland connective tissue morphology	LPA PLG	8.45e-05	2	129	2	MP:0009507
MousePheno	ectropion	LPA PLG	8.45e-05	2	129	2	MP:0006164
MousePheno	esophageal ulcer	LPA PLG	8.45e-05	2	129	2	MP:0004547
MousePheno	duodenal ulcer	LPA PLG	8.45e-05	2	129	2	MP:0003273
MousePheno	perianal ulcer	LPA PLG	8.45e-05	2	129	2	MP:0005035
MousePheno	abnormal keratinocyte migration	EPPK1 LPA PLG	1.20e-04	11	129	3	MP:0012192
Domain	PyrdxlP-dep_de-COase	DDC SGPL1 CSAD HDC	3.11e-07	8	155	4	IPR002129
Domain	Pyridoxal_deC	DDC SGPL1 CSAD HDC	3.11e-07	8	155	4	PF00282
Domain	DDC_GAD_HDC_YDC	DDC SGPL1 CSAD HDC	3.11e-07	8	155	4	PS00392
Domain	Kringle-like	IGF2R MRC2 LPA HABP2 PLG	6.20e-06	32	155	5	IPR013806
Domain	TRYPSIN_HIS	KLK3 OVCH1 PRSS36 LPA TMPRSS2 HABP2 PLG	2.41e-05	103	155	7	IPR018114
Domain	-	PNLIPRP1 PKD1L2 DENND5A PNLIPRP3	2.45e-05	21	155	4	2.60.60.20
Domain	PLAT	PNLIPRP1 PKD1L2 DENND5A PNLIPRP3	2.45e-05	21	155	4	PF01477
Domain	PLAT/LH2_dom	PNLIPRP1 PKD1L2 DENND5A PNLIPRP3	2.45e-05	21	155	4	IPR001024
Domain	PLAT	PNLIPRP1 PKD1L2 DENND5A PNLIPRP3	2.45e-05	21	155	4	PS50095
Domain	TRYPSIN_SER	KLK3 OVCH1 PRSS36 LPA TMPRSS2 HABP2 PLG	2.90e-05	106	155	7	PS00135
Domain	TRYPSIN_HIS	KLK3 OVCH1 PRSS36 LPA TMPRSS2 HABP2 PLG	3.08e-05	107	155	7	PS00134
Domain	Peptidase_S1A	KLK3 OVCH1 PRSS36 LPA TMPRSS2 HABP2 PLG	4.38e-05	113	155	7	IPR001314
Domain	TRYPSIN_DOM	KLK3 OVCH1 PRSS36 LPA TMPRSS2 HABP2 PLG	4.90e-05	115	155	7	PS50240
Domain	Tryp_SPc	KLK3 OVCH1 PRSS36 LPA TMPRSS2 HABP2 PLG	5.47e-05	117	155	7	SM00020
Domain	Trypsin_dom	KLK3 OVCH1 PRSS36 LPA TMPRSS2 HABP2 PLG	6.78e-05	121	155	7	IPR001254
Domain	Trypsin	KLK3 OVCH1 PRSS36 LPA TMPRSS2 HABP2 PLG	6.78e-05	121	155	7	PF00089
Domain	Aromatic_deC	DDC HDC	6.84e-05	2	155	2	IPR010977
Domain	-	CSMD2 OVCH1 ZZEF1 CSMD3 MEGF8	7.00e-05	52	155	5	2.60.120.290
Domain	Peptidase_S1_PA	KLK3 OVCH1 PRSS36 LPA TMPRSS2 HABP2 PLG	7.52e-05	123	155	7	IPR009003
Domain	TRYPSIN_SER	KLK3 OVCH1 PRSS36 TMPRSS2 HABP2 PLG	1.04e-04	90	155	6	IPR033116
Domain	CUB_dom	CSMD2 OVCH1 ZZEF1 CSMD3 MEGF8	1.09e-04	57	155	5	IPR000859
Domain	EamA	SLC35G4 SLC35F3 SLC35G3	1.91e-04	14	155	3	PF00892
Domain	EamA_dom	SLC35G4 SLC35F3 SLC35G3	1.91e-04	14	155	3	IPR000620
Domain	PROL5-SMR	SMR3A SMR3B	2.04e-04	3	155	2	PF15621
Domain	SMR-like	SMR3A SMR3B	2.04e-04	3	155	2	IPR026288
Domain	-	DDC SGPL1 CSAD HDC	2.99e-04	39	155	4	3.40.640.10
Domain	Kringle_CS	LPA HABP2 PLG	3.50e-04	17	155	3	IPR018056
Domain	KRINGLE_1	LPA HABP2 PLG	3.50e-04	17	155	3	PS00021
Domain	KR	LPA HABP2 PLG	3.50e-04	17	155	3	SM00130
Domain	Kringle	LPA HABP2 PLG	3.50e-04	17	155	3	IPR000001
Domain	KRINGLE_2	LPA HABP2 PLG	3.50e-04	17	155	3	PS50070
Domain	Kringle	LPA HABP2 PLG	3.50e-04	17	155	3	PF00051
Domain	PyrdxlP-dep_Trfase	DDC SGPL1 CSAD HDC	3.64e-04	41	155	4	IPR015424
Domain	PyrdxlP-dep_Trfase_major_sub1	DDC SGPL1 CSAD HDC	3.64e-04	41	155	4	IPR015421
Domain	Glyco_transf_22	PIGZ ALG9	4.06e-04	4	155	2	PF03901
Domain	Lipase_panc	PNLIPRP1 PNLIPRP3	4.06e-04	4	155	2	IPR002331
Domain	GPI_mannosylTrfase	PIGZ ALG9	4.06e-04	4	155	2	IPR005599
Domain	DAG/PE-bd	RASGRP4 ARAF PRKCG	6.68e-04	21	155	3	IPR020454
Domain	Pyridoxal-P_BS	DDC HDC	6.73e-04	5	155	2	IPR021115
Domain	CUB	CSMD2 OVCH1 CSMD3 MEGF8	7.23e-04	49	155	4	PF00431
Domain	CUB	CSMD2 OVCH1 CSMD3 MEGF8	7.81e-04	50	155	4	SM00042
Domain	CUB	CSMD2 OVCH1 CSMD3 MEGF8	9.74e-04	53	155	4	PS01180
Domain	HNOB_dom_associated	GUCY2F GUCY2D	1.00e-03	6	155	2	IPR011645
Domain	HNOBA	GUCY2F GUCY2D	1.00e-03	6	155	2	PF07701
Domain	C1-set	HLA-DRB1 HLA-DRB3 IGHD TAPBP	1.05e-03	54	155	4	PF07654
Domain	Ig_C1-set	HLA-DRB1 HLA-DRB3 IGHD TAPBP	1.37e-03	58	155	4	IPR003597
Domain	IG_MHC	HLA-DRB1 HLA-DRB3 IGHD TAPBP	1.55e-03	60	155	4	PS00290
Domain	EGF_2	LAMA1 SSPOP CD93 HMCN2 MEGF8 HABP2 C7 ADGRE1	1.69e-03	265	155	8	PS01186
Domain	MHC_II_b_N	HLA-DRB1 HLA-DRB3	1.85e-03	8	155	2	PD000328
Domain	Growth_fac_rcpt_	LAMA1 GPR179 CD93 HMCN2 MEGF8 ADGRE1	1.94e-03	156	155	6	IPR009030
Domain	Ig-like_fold	EPOR DSCAM HLA-DRB1 NTRK2 HLA-DRB3 PKHD1L1 KIRREL3 BTN2A2 HMCN2 IGHD IL3RA TAPBP PLXNA1 IL27RA	2.28e-03	706	155	14	IPR013783
Domain	MHC_II_b_N	HLA-DRB1 HLA-DRB3	2.37e-03	9	155	2	IPR000353
Domain	MHC_II_beta	HLA-DRB1 HLA-DRB3	2.37e-03	9	155	2	SM00921
Domain	MHC_II_beta	HLA-DRB1 HLA-DRB3	2.37e-03	9	155	2	PF00969
Domain	GPS	ADGRB2 PKD1L2 ADGRE1	2.78e-03	34	155	3	SM00303
Domain	Lipase/vitellogenin	PNLIPRP1 PNLIPRP3	2.95e-03	10	155	2	IPR013818
Domain	TAG_lipase	PNLIPRP1 PNLIPRP3	2.95e-03	10	155	2	IPR000734
Domain	Lipase	PNLIPRP1 PNLIPRP3	2.95e-03	10	155	2	PF00151
Domain	Lipase_N	PNLIPRP1 PNLIPRP3	2.95e-03	10	155	2	IPR033906
Domain	Lipase_LIPH	PNLIPRP1 PNLIPRP3	2.95e-03	10	155	2	IPR016272
Domain	-	DDC CSAD HDC	3.02e-03	35	155	3	3.90.1150.10
Domain	GPS	ADGRB2 PKD1L2 ADGRE1	3.02e-03	35	155	3	PF01825
Domain	-	PNLIPRP1 ACHE APEH SCPEP1 PNLIPRP3	3.16e-03	119	155	5	3.40.50.1820
Domain	AB_hydrolase	PNLIPRP1 ACHE APEH SCPEP1 PNLIPRP3	3.16e-03	119	155	5	IPR029058
Domain	PyrdxlP-dep_Trfase_major_sub2	DDC CSAD HDC	3.27e-03	36	155	3	IPR015422
Domain	GPS	ADGRB2 PKD1L2 ADGRE1	3.27e-03	36	155	3	PS50221
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	EPPK1 SZT2 KIF26A ADGRB2 APEH GEMIN5 CEP192 TEP1 ZZEF1 TRRAP ARSG RYR1 TBC1D17 GDPD5 C2CD3 IGF2R MEGF8 CSAD DENND5A PLXNA1	2.20e-07	1105	161	20	35748872
Pubmed	Soluble M6P/IGF2R released by TACE controls angiogenesis via blocking plasminogen activation.	IGF2R LPA PLG	9.67e-07	5	161	3	21273553
Pubmed	The Lx1 gene maps to mouse chromosome 17 and codes for a protein that is homologous to glucose and polyspecific transmembrane transporters.	IGF2R LPA PLG	9.67e-07	5	161	3	8854860
Pubmed	CCL2/MCP-1 signaling drives extracellular matrix turnover by diverse macrophage subsets.	MRC2 LPA PLG	1.93e-06	6	161	3	33543002
Pubmed	Histone H3 lysine 36 methyltransferase Hypb/Setd2 is required for embryonic vascular remodeling.	LAMA1 ANGPTL6 LPA PLG	2.02e-06	20	161	4	20133625
Pubmed	Insulin-like growth factor II receptor, transforming growth factor-beta, and Cdk4 expression and the developmental epigenetics of mouse palate morphogenesis and dysmorphogenesis.	IGF2R LPA PLG	5.36e-06	8	161	3	9438420
Pubmed	Bidirectional action of the Igf2r imprint control element on upstream and downstream imprinted genes.	IGF2R LPA PLG	5.36e-06	8	161	3	11562346
Pubmed	The mouse insulin-like growth factor type-2 receptor is imprinted and closely linked to the Tme locus.	IGF2R LPA PLG	5.36e-06	8	161	3	1845916
Pubmed	Long-range DNase I hypersensitivity mapping reveals the imprinted Igf2r and Air promoters share cis-regulatory elements.	IGF2R LPA PLG	5.36e-06	8	161	3	16204191
Pubmed	Tissue-specific regulation of Igf2r/Airn imprinting during gastrulation.	IGF2R LPA PLG	8.01e-06	9	161	3	25918552
Pubmed	A genome-wide association study identifies protein quantitative trait loci (pQTLs).	SASH1 KIRREL3 ANGPTL6 LPA ATP2A2	9.64e-06	61	161	5	18464913
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	TNFSF9 LAMA1 CD109 RNF149 ERMP1 ZZEF1 SLC39A13 XYLT2 IGF2R MEGF8 MRC2 SGPL1 ALG9 FHOD1 SCPEP1 ATP2A2 TAPBP PLXNA1	1.26e-05	1201	161	18	35696571
Pubmed	Characterization of the C3 YAC contig from proximal mouse chromosome 17 and analysis of allelic expression of genes flanking the imprinted Igf2r gene.	IGF2R LPA PLG	1.56e-05	11	161	3	9268631
Pubmed	Mapping the Hrc gene to proximal mouse chromosome 7: delineation of a conserved linkage group with human 19q.	KLK3 RYR1 PRKCG	2.08e-05	12	161	3	8288260
Pubmed	Paediatric celiac patients carrying the HLA-DR7-DQ2 and HLA-DR3-DQ2 haplotypes display small clinical differences.	HLA-DRB1 HLA-DRB3	2.13e-05	2	161	2	24628273
Pubmed	Persistent corneal haze after excimer laser photokeratectomy in plasminogen-deficient mice.	LPA PLG	2.13e-05	2	161	2	10634603
Pubmed	Thrombomodulin functions as a plasminogen receptor to modulate angiogenesis.	LPA PLG	2.13e-05	2	161	2	23943648
Pubmed	Plasminogen deficiency causes severe thrombosis but is compatible with development and reproduction.	LPA PLG	2.13e-05	2	161	2	7705657
Pubmed	Nucleocytoplasmic coagulation: an injury-induced aggregation event that disulfide crosslinks proteins and facilitates their removal by plasmin.	LPA PLG	2.13e-05	2	161	2	23041318
Pubmed	A novel role for plasmin-mediated degradation of opsonizing antibody in the evasion of host immunity by virulent, but not attenuated, Francisella tularensis.	LPA PLG	2.13e-05	2	161	2	19752236
Pubmed	Complement component C7 is a plasminogen-binding protein.	C7 PLG	2.13e-05	2	161	2	7814888
Pubmed	Plasminogen Tochigi: inactive plasmin resulting from replacement of alanine-600 by threonine in the active site.	LPA PLG	2.13e-05	2	161	2	6216475
Pubmed	Mutations and selection in the generation of class II histocompatibility antigen polymorphism.	HLA-DRB1 HLA-DRB3	2.13e-05	2	161	2	6589154
Pubmed	Tissue-type plasminogen activator is a neuroprotectant in the mouse hippocampus.	LPA PLG	2.13e-05	2	161	2	20440070
Pubmed	Cloning and expression of a second photoreceptor-specific membrane retina guanylyl cyclase (RetGC), RetGC-2.	GUCY2F GUCY2D	2.13e-05	2	161	2	7777544
Pubmed	A central role for plasminogen in the inflammatory response to biomaterials.	LPA PLG	2.13e-05	2	161	2	15456492
Pubmed	DRB1*03 diversity and DRB3 associations in five major population groups in the United States.	HLA-DRB1 HLA-DRB3	2.13e-05	2	161	2	11872240
Pubmed	Staphylococcus aureus manganese transport protein C (MntC) is an extracellular matrix- and plasminogen-binding protein.	LPA PLG	2.13e-05	2	161	2	25409527
Pubmed	Restoration of thrombolytic potential in plasminogen-deficient mice by bolus administration of plasminogen.	LPA PLG	2.13e-05	2	161	2	8704243
Pubmed	A cellular and functional split in the DRw8 haplotype is due to a single amino acid replacement (DR beta ser 57- asp 57).	HLA-DRB1 HLA-DRB3	2.13e-05	2	161	2	2497068
Pubmed	Plasmin promotes foam cell formation by increasing macrophage catabolism of aggregated low-density lipoprotein.	LPA PLG	2.13e-05	2	161	2	23702659
Pubmed	Structural and functional analogies and differences between histidine decarboxylase and aromatic l-amino acid decarboxylase molecular networks: Biomedical implications.	DDC HDC	2.13e-05	2	161	2	27769832
Pubmed	The conundrum of HLA-DRB114:01/14:54 and HLA-DRB302:01/02:02 mismatches in unrelated hematopoietic SCT.	HLA-DRB1 HLA-DRB3	2.13e-05	2	161	2	20972469
Pubmed	Dengue virus-induced autoantibodies bind to plasminogen and enhance its activation.	LPA PLG	2.13e-05	2	161	2	22079981
Pubmed	Plasminogen deficiency differentially affects recruitment of inflammatory cell populations in mice.	LPA PLG	2.13e-05	2	161	2	9490683
Pubmed	Kringle 5 of human plasminogen suppresses hepatocellular carcinoma growth both in grafted and xenografted mice by anti-angiogenic activity.	LPA PLG	2.13e-05	2	161	2	16481742
Pubmed	Apolipoprotein(a) inhibits the conversion of Glu-plasminogen to Lys-plasminogen: a novel mechanism for lipoprotein(a)-mediated inhibition of plasminogen activation.	LPA PLG	2.13e-05	2	161	2	18983515
Pubmed	Plasminogen Regulates Fracture Repair by Promoting the Functions of Periosteal Mesenchymal Progenitors.	LPA PLG	2.13e-05	2	161	2	34378815
Pubmed	Plasmin generation plays different roles in the formation and removal of arterial and venous thrombus in mice.	LPA PLG	2.13e-05	2	161	2	11848464
Pubmed	Effects of disruption of the plasminogen gene on thrombosis, growth, and health in mice.	LPA PLG	2.13e-05	2	161	2	7586361
Pubmed	Plasminogen/plasmin modulates bone metabolism by regulating the osteoblast and osteoclast function.	LPA PLG	2.13e-05	2	161	2	21239499
Pubmed	Plasminogen-independent initiation of the pro-urokinase activation cascade in vivo. Activation of pro-urokinase by glandular kallikrein (mGK-6) in plasminogen-deficient mice.	LPA PLG	2.13e-05	2	161	2	10642175
Pubmed	Plasminogen mRNA induction in the mouse brain after kainate excitation: codistribution with plasminogen activator inhibitor-2 (PAI-2) mRNA.	LPA PLG	2.13e-05	2	161	2	12225871
Pubmed	Plasminogen deficiency suppresses pancreatic ductal adenocarcinoma disease progression.	LPA PLG	2.13e-05	2	161	2	37971174
Pubmed	The plasminogen activation system enhances brain and heart invasion in murine relapsing fever borreliosis.	LPA PLG	2.13e-05	2	161	2	9884337
Pubmed	Development of a new HLA-DRB real-time PCR typing method.	HLA-DRB1 HLA-DRB3	2.13e-05	2	161	2	15620466
Pubmed	Colonic Lesions, Cytokine Profiles, and Gut Microbiota in Plasminogen-Deficient Mice.	LPA PLG	2.13e-05	2	161	2	26473342
Pubmed	Regulation of anti-cyclic citrullinated peptide antibodies in rheumatoid arthritis: contrasting effects of HLA-DR3 and the shared epitope alleles.	HLA-DRB1 HLA-DRB3	2.13e-05	2	161	2	16320316
Pubmed	Selection of mutant µplasmin for amyloid-β cleavage in vivo.	LPA PLG	2.13e-05	2	161	2	32694536
Pubmed	Cutting edge: permissive MHC class II allele changes the pattern of antitumor immune response resulting in failure of tumor rejection.	HLA-DRB1 KLK3	2.13e-05	2	161	2	19155468
Pubmed	Description of two new HLA-DRB alleles (DRB10310 and DRB301012) found in a Spanish infant.	HLA-DRB1 HLA-DRB3	2.13e-05	2	161	2	9234492
Pubmed	Role of plasminogen in propagation of scrapie.	LPA PLG	2.13e-05	2	161	2	16103174
Pubmed	Histidine decarboxylase deficiency causes tourette syndrome: parallel findings in humans and mice.	DDC HDC	2.13e-05	2	161	2	24411733
Pubmed	Differential expression of oxidized/native lipoprotein(a) and plasminogen in human carotid and cerebral artery plaques.	LPA PLG	2.13e-05	2	161	2	21300353
Pubmed	Selective behaviors altered in plasminogen-deficient mice are reconstituted with intracerebroventricular injection of plasminogen.	LPA PLG	2.13e-05	2	161	2	11306011
Pubmed	Localization of regulatory elements mediating constitutive and cytokine-stimulated plasminogen gene expression.	LPA PLG	2.13e-05	2	161	2	12149246
Pubmed	Protective effects of plasmin(ogen) in a mouse model of Staphylococcus aureus-induced arthritis.	LPA PLG	2.13e-05	2	161	2	18311818
Pubmed	Localization of plasminogen in mouse hippocampus, cerebral cortex, and hypothalamus.	LPA PLG	2.13e-05	2	161	2	21190118
Pubmed	A physiological function for apolipoprotein(a): a natural regulator of the inflammatory response.	LPA PLG	2.13e-05	2	161	2	18997104
Pubmed	Growth and behavioral development in plasminogen gene-targeted mice.	LPA PLG	2.13e-05	2	161	2	10885855
Pubmed	Cellular density regulation of plasminogen gene expression in mouse hepatocytes.	LPA PLG	2.13e-05	2	161	2	12559391
Pubmed	Tracking antigen-specific T-cells during clinical tolerance induction in humans.	HLA-DRB1 HLA-DRB3	2.13e-05	2	161	2	20543955
Pubmed	Plasminogen is a critical host pathogenicity factor for group A streptococcal infection.	LPA PLG	2.13e-05	2	161	2	15333838
Pubmed	Apo(a) promotes thrombosis in a vascular injury model by a mechanism independent of plasminogen.	LPA PLG	2.13e-05	2	161	2	16150044
Pubmed	Plasminogen has a broad extrahepatic distribution.	LPA PLG	2.13e-05	2	161	2	11916082
Pubmed	Delayed invasion of the kidney and brain by Borrelia crocidurae in plasminogen-deficient mice.	LPA PLG	2.13e-05	2	161	2	11500461
Pubmed	Association of HLA-DR3 with anti-cyclic citrullinated peptide antibody-negative rheumatoid arthritis.	HLA-DRB1 HLA-DRB3	2.13e-05	2	161	2	16200610
Pubmed	Role of plasminogen activation in neuronal organization and survival.	LPA PLG	2.13e-05	2	161	2	19683575
Pubmed	Plasminogen controls inflammation and pathogenesis of influenza virus infections via fibrinolysis.	LPA PLG	2.13e-05	2	161	2	23555246
Pubmed	HLA-DRB115:01 and HLA-DRB302:02 in PLA2R-Related Membranous Nephropathy.	HLA-DRB1 HLA-DRB3	2.13e-05	2	161	2	28028136
Pubmed	Binding of plasminogen to hepatocytes isolated from injured mouse liver and nonparenchymal-cell-dependent proliferation of hepatocytes.	LPA PLG	2.13e-05	2	161	2	18685433
Pubmed	Plasminogen mediates communication between the peripheral and central immune systems during systemic immune challenge with lipopolysaccharide.	LPA PLG	2.13e-05	2	161	2	31462325
Pubmed	The mannose 6-phosphate/insulin-like growth factor 2 receptor mediates plasminogen-induced efferocytosis.	IGF2R PLG	2.13e-05	2	161	2	30657605
Pubmed	HLA-DRB1 and -DRB3 allele frequencies and haplotypic associations in Koreans.	HLA-DRB1 HLA-DRB3	2.13e-05	2	161	2	15041167
Pubmed	Short-term inhibition of fibrinolytic system restores locomotor function after spinal cord injury in mice.	LPA PLG	2.13e-05	2	161	2	31690812
Pubmed	Blood-derived plasminogen drives brain inflammation and plaque deposition in a mouse model of Alzheimer's disease.	LPA PLG	2.13e-05	2	161	2	30254165
Pubmed	Plasminogen deficiency exacerbates skeletal muscle loss during mechanical unloading in developing mice.	LPA PLG	2.13e-05	2	161	2	38328826
Pubmed	The unusual DRB108:01 haplotype carrying DRB302:02 confirmed in a Dutch family.	HLA-DRB1 HLA-DRB3	2.13e-05	2	161	2	23742216
Pubmed	Reduced transplant arteriosclerosis in plasminogen-deficient mice.	LPA PLG	2.13e-05	2	161	2	9819364
Pubmed	In vivo plasminogen deficiency reduces fat accumulation.	LPA PLG	2.13e-05	2	161	2	12083480
Pubmed	Generation of angiostatin-like fragments from plasminogen by prostate-specific antigen.	KLK3 PLG	2.13e-05	2	161	2	10604721
Pubmed	Polymorphonuclear leukocyte phagocytic function increases in plasminogen knockout mice.	LPA PLG	2.13e-05	2	161	2	18420257
Pubmed	Plasminogen alleles influence susceptibility to invasive aspergillosis.	LPA PLG	2.13e-05	2	161	2	18566672
Pubmed	Enhanced detection of neoantigen-reactive T cells targeting unique and shared oncogenes for personalized cancer immunotherapy.	HLA-DRB1 HLA-DRB3	2.13e-05	2	161	2	30282837
Pubmed	KLK3 and TMPRSS2 for molecular lymph-node staging in prostate cancer patients undergoing radical prostatectomy.	KLK3 TMPRSS2	2.13e-05	2	161	2	32978525
Pubmed	The generation and characterization of mice expressing a plasmin-inactivating active site mutation.	LPA PLG	2.13e-05	2	161	2	20653841
Pubmed	Influence of plasminogen deficiency on the contribution of polymorphonuclear leucocytes to fibrin/ogenolysis: studies in plasminogen knock-out mice.	LPA PLG	2.13e-05	2	161	2	12428098
Pubmed	Plasminogen deficiency causes reduced corticospinal axonal plasticity and functional recovery after stroke in mice.	LPA PLG	2.13e-05	2	161	2	24732409
Pubmed	[An evaluation of HLA class 2 alleles and anti-islet antibodies as evidence for non-autoimmune diabetes in Wolfram syndrome].	HLA-DRB1 HLA-DRB3	2.13e-05	2	161	2	21447263
Pubmed	HLA-DRB1 reduces the risk of type 2 diabetes mellitus by increased insulin secretion.	HLA-DRB1 HLA-DRB3	2.13e-05	2	161	2	21484216
Pubmed	Plasminogen promotes macrophage phagocytosis in mice.	LPA PLG	2.13e-05	2	161	2	24876560
Pubmed	Plasminogen is a joint-specific positive or negative determinant of arthritis pathogenesis in mice.	LPA PLG	2.13e-05	2	161	2	24574269
Pubmed	Spontaneous development of otitis media in plasminogen-deficient mice.	LPA PLG	2.13e-05	2	161	2	16956791
Pubmed	The mouse plasminogen locus maps to the recombination breakpoints of the tLub2 and TtOrl partial t haplotypes but is not at the tw73 locus.	LPA PLG	2.13e-05	2	161	2	1543918
Pubmed	Plasmin(ogen) promotes renal interstitial fibrosis by promoting epithelial-to-mesenchymal transition: role of plasmin-activated signals.	LPA PLG	2.13e-05	2	161	2	17267741
Pubmed	Interaction of acetylcholinesterase with the G4 domain of the laminin alpha1-chain.	ACHE LAMA1	2.13e-05	2	161	2	18215127
Pubmed	Apolipoprotein(a) inhibits the conversion of Glu-plasminogen to Lys-plasminogen on the surface of vascular endothelial and smooth muscle cells.	LPA PLG	2.13e-05	2	161	2	29990619
Pubmed	Reduction of experimental diabetic vascular leakage by delivery of angiostatin with a recombinant adeno-associated virus vector.	LPA PLG	2.13e-05	2	161	2	17293777
Pubmed	Plasminogen plays a crucial role in bone repair.	LPA PLG	2.13e-05	2	161	2	23456978
Pubmed	Disruption of the plasminogen gene in mice abolishes wound healing after myocardial infarction.	LPA PLG	2.13e-05	2	161	2	10854210
Cytoband	6q26	IGF2R LPA PLG	3.26e-05	18	160	3	6q26
Cytoband	10q25.3	PNLIPRP1 HABP2 PNLIPRP3	1.42e-04	29	160	3	10q25.3
GeneFamily	Solute carriers	SLC37A1 SLC16A13 FLVCR1 SLC7A6 SLC39A13 SLC35G4 SLC12A5 SLC35F3 SLC35G3 SLC9B2 SLC10A6 SLC14A2	4.65e-06	395	109	12	752
GeneFamily	Guanylate cyclase receptors	GUCY2F GUCY2D	7.42e-04	7	109	2	343
GeneFamily	Dolichyl D-mannosyl phosphate dependent mannosyltransferases\|Phosphatidylinositol glycan anchor biosynthesis	PIGZ ALG9	1.26e-03	9	109	2	430
GeneFamily	C1-set domain containing	HLA-DRB1 HLA-DRB3 TAPBP	2.06e-03	42	109	3	591
Coexpression	MILI_PSEUDOPODIA_HAPTOTAXIS_DN	ATG16L1 SLC16A13 EPPK1 TNFSF9 TAF1C CD109 ERMP1 SLC7A6 ZZEF1 SLC39A13 ABCB10 MRC2 SGPL1 ALG9 TMEM19 ATP2A2 PLXNA1	7.67e-07	681	157	17	M5314
Coexpression	MILI_PSEUDOPODIA_HAPTOTAXIS_DN	ATG16L1 SLC16A13 EPPK1 TNFSF9 TAF1C CD109 ERMP1 SLC7A6 ZZEF1 SLC39A13 ABCB10 MRC2 SGPL1 ALG9 TMEM19 ATP2A2 PLXNA1	1.18e-06	703	157	17	MM1055
CoexpressionAtlas	Myeloid Cells, MF.Thio5.II+480lo.PC, CD115+ MHC II+ F480lo SiglecF- CD11c+, Peritoneal Cavity, avg-3	RASGRP4 TMEM176B ARRDC4 HLA-DRB1 FLVCR1 TEP1 CD93 ABCA6 MAMDC2 ATG4C SCPEP1 ADGRE1 PLXNA1	1.01e-05	426	149	13	GSM605859_500
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MGAM LAMA1 PKD1L2 CSMD3 SSPOP PKHD1L1 PIEZO2 GUCY2F OTOGL	2.09e-08	184	158	9	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MGAM LAMA1 PKD1L2 CSMD3 SSPOP PKHD1L1 PIEZO2 GUCY2F OTOGL	2.09e-08	184	158	9	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MGAM LAMA1 PKD1L2 CSMD3 SSPOP PKHD1L1 PIEZO2 GUCY2F OTOGL	2.09e-08	184	158	9	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	367C-Myeloid-Macrophage-M2-like_Macrophage_(MARCO_negative)\|Macrophage / Donor, Lineage, Cell class and subclass (all cells)	CTTNBP2 TMEM176B HLA-DRB1 IRAG1 SLC12A5 CD93 ABCA6 MAMDC2 LPAR6	3.60e-08	196	158	9	e8c4eeb4b6c6d9bccca2adb942d4cfbaab39636c
ToppCell	368C-Myeloid-Macrophage-M2-like_Macrophage_(MARCO_negative)\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	TMEM176B HLA-DRB1 IRAG1 SLC12A5 CD93 MAMDC2 LPAR6	1.94e-06	163	158	7	4b8abbad4df040c895e3afb240759ebbc66b4d0e
ToppCell	tumor_Lymph_Node_/_Brain-Myeloid_cells-Alveolar_Mac\|tumor_Lymph_Node_/_Brain / Location, Cell class and cell subclass	TMEM176B ARRDC4 HLA-DRB1 OVCH1 SCPEP1 ADGRE1 IL3RA	2.88e-06	173	158	7	4efa0878ed1ede8fa5d6c191a76d4f70558ba761
ToppCell	Mid-temporal_gyrus_(MTG)\|World / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	KIRREL3 SHC2 SLC35F3 OTOGL PRKCG SCPEP1 PLXNA1	3.48e-06	178	158	7	ad187db4c40b9078d54dd915c143e0172b2f47b8
ToppCell	droplet-Kidney-nan-21m-Epithelial-Pecam____kidney_capillary_endothelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACHE NTRK2 MCC SLC12A5 PIEZO2 P2RX2 MRC2	4.17e-06	183	158	7	f55081068213cc1cdb2acad58ff10f6b48b44c72
ToppCell	LAM-Myeloid-DC\|LAM / Condition, Lineage and Cell class	ACSL6 TMEM176B HLA-DRB1 SLC12A5 CD93 MAMDC2 LPAR6	4.98e-06	188	158	7	b4140110c2f7d25fd8a0d2749e33e02003ac4bf2
ToppCell	PND01-03-samps-Mesenchymal-Matrix_fibroblast-MatrixFB-A\|PND01-03-samps / Age Group, Lineage, Cell class and subclass	IGF2R ABCA6 MRC2 CSAD FHOD1 SLC10A6 PRKG2	5.53e-06	191	158	7	e7c605b56934d1383237c1f946dbccef25d91368
ToppCell	PCW_05-06-Endothelial-Endothelial_mature-endo_capillary_(2)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	TBXA2R TMEM176B NTRK2 CD109 CD93 GDPD5 IL3RA	5.92e-06	193	158	7	4f38aae346ea3b4258744e9dc1e5aeb4fea13d06
ToppCell	LAM-Myeloid-DC\|Myeloid / Condition, Lineage and Cell class	ACSL6 TMEM176B HLA-DRB1 CD93 ABCA6 MAMDC2 LPAR6	5.92e-06	193	158	7	f665cce40053ae5d6e28f9f70ddf78e8598c9514
ToppCell	367C-Myeloid-Macrophage-M2-like_Macrophage_(MARCO_negative)\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	TMEM176B HLA-DRB1 SLC12A5 CD93 ABCA6 MAMDC2 LPAR6	6.33e-06	195	158	7	4008fa86b5166087a4b20f89ae07e1dfc87c855d
ToppCell	(3)_MNP-(3)_Macrophage_MARCOneg\|(3)_MNP / Lung cell shreds - cell class (v4) and cell subclass (v4)	TMEM176B HLA-DRB1 SLC12A5 CD93 ABCA6 MAMDC2 LPAR6	6.33e-06	195	158	7	e4b5e4b8832669fb4d1661ecd828b81e621d35c4
ToppCell	LPS_IL1RA-Epithelial_alveolar-AT_1-Differentiating_AT2\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	SLC37A1 PNLIPRP1 CSMD2 AOPEP OSBPL3 CSAD TMPRSS2	6.77e-06	197	158	7	b94645d57efe8d9e032bffb8c89af1f425c6421e
ToppCell	Transverse-(5)_Dendritic_cell-(53)_Lymphoid_DC\|Transverse / shred on region, Cell_type, and subtype	TMEM176B RYR1 ANGPTL6 PIEZO2 ABCA6 AOPEP DENND5A	6.77e-06	197	158	7	15b87fd3906d7388c271d30d0c64b1bcc490801c
ToppCell	Transverse-Dendritic_cell-Lymphoid_DC\|Transverse / Region, Cell class and subclass	TMEM176B RYR1 ANGPTL6 PIEZO2 ABCA6 AOPEP DENND5A	6.77e-06	197	158	7	a58af0ea82f76f2a7abac1f62629ff20d552fc63
ToppCell	distal-mesenchymal-Alveolar_Fibroblast-1\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	TMEM176B PKD1L2 ABCA6 MRC2 MAMDC2 NOTO C7	6.99e-06	198	158	7	7f728ca6d5317890c6fcde3ce6c10c0970d49a05
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-OPC-OPC-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	NEU4 DSCAM NTRK2 C10orf90 CSMD2 CSMD3 PRKG2	7.23e-06	199	158	7	19a97e27a4758e794ce7246d295e112b47931a48
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW16-Neuroepithelial\|GW16 / Sample Type, Dataset, Time_group, and Cell type.	TMEM176B IRAG1 MRC2 LPAR6 FHOD1 SCPEP1 ACSL5	7.47e-06	200	158	7	25f4c051c2e869481f33c22ad54de97efac444ad
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW16-Neuroepithelial-Proteoglycan-expressing_cell\|GW16 / Sample Type, Dataset, Time_group, and Cell type.	TMEM176B IRAG1 MRC2 LPAR6 FHOD1 SCPEP1 ACSL5	7.47e-06	200	158	7	da45a85a4667965b24ba824af871157af5b4cd19
ToppCell	Frontal_cortex-Endothelial-ENDOTHELIAL_TIP-Dcn_2-Dcn_2_2\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	PDE6H CD109 SMR3A PIEZO2 SLC9B2 TMPRSS2	8.82e-06	135	158	6	4451c44f3ad788437f4e2ae81049fbbab53f967e
ToppCell	Frontal_cortex-Endothelial-ENDOTHELIAL_TIP-Dcn_2\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	PDE6H CD109 SMR3A PIEZO2 SLC9B2 TMPRSS2	8.82e-06	135	158	6	45f67f33c8320d9fb6dbceae603b564f6a8ffd1e
ToppCell	Posterior_cortex-Macroglia-POLYDENDROCYTE-P2-Tnr-Polydendrocyte.Tnr.Tmsb4x_(Tmsb4x)\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	NEU4 TNFSF9 BECN2 GUCY2F C7	1.39e-05	86	158	5	db67c05c876a5649371c0dc6c941cc371bc2feb8
ToppCell	Posterior_cortex-Macroglia-POLYDENDROCYTE-P2-Tnr-Polydendrocyte.Tnr.Tmsb4x_(Tmsb4x)-\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	NEU4 TNFSF9 BECN2 GUCY2F C7	1.39e-05	86	158	5	2778446e035c5585bce28ed0ef93b87b6ad90c6e
ToppCell	Smart-seq2-lymph_node_(Smart-seq2)-myeloid-myeloid_granulocytic\|lymph_node_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	RASGRP4 CTTNBP2 TMEM176B CD109 PRKG2 HDC	1.73e-05	152	158	6	32634195048858ae84605c61e43c542d90f7cab5
ToppCell	Smart-seq2-lymph_node_(Smart-seq2)-myeloid-myeloid_granulocytic-mast_cell\|lymph_node_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	RASGRP4 CTTNBP2 TMEM176B CD109 PRKG2 HDC	1.73e-05	152	158	6	0eb185b2404f015efff1bd140e0c502d714720fb
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-high_Fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ACHE FLVCR1 KLK3 ABCA6 LPA C7	2.23e-05	159	158	6	330ecbba97d47bc818a5e8d1d84b05d056bd831e
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-high_Fibroblast-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ACHE FLVCR1 KLK3 ABCA6 LPA C7	2.23e-05	159	158	6	cbb331eb689d8cea9e1146ba85e0a05d23301c47
ToppCell	Cerebellum-Macroglia-OLIGODENDROCYTE-O2-Trf-Oligodendrocyte.Trf.Klk6_(Klk6)\|Cerebellum / BrainAtlas - Mouse McCarroll V32	NEU4 C10orf90 PIEZO2 ABCA6 SLC9B2	2.37e-05	96	158	5	a48235df1f5526ce3ffc4c0c2ba038eb20229c55
ToppCell	Cerebellum-Macroglia-OLIGODENDROCYTE-O2-Trf-Oligodendrocyte.Trf.Klk6_(Klk6)-\|Cerebellum / BrainAtlas - Mouse McCarroll V32	NEU4 C10orf90 PIEZO2 ABCA6 SLC9B2	2.37e-05	96	158	5	0fc179af7370a29b7bd5d81e1302a479ae72f196
ToppCell	Cerebellum-Macroglia-OLIGODENDROCYTE-O2-Trf\|Cerebellum / BrainAtlas - Mouse McCarroll V32	NEU4 C10orf90 PIEZO2 ABCA6 SLC9B2	2.37e-05	96	158	5	c301ecfd67ece8bb12be1b94b614957a58046457
ToppCell	Cerebellum-Macroglia-OLIGODENDROCYTE-O2\|Cerebellum / BrainAtlas - Mouse McCarroll V32	NEU4 C10orf90 PIEZO2 ABCA6 SLC9B2	2.37e-05	96	158	5	7d402d543ff159c9bb84c00b083e6e18fc0ff786
ToppCell	356C-Myeloid-Macrophage-SPP1+_Macrophage_4\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	AZIN2 PRSS36 SLC12A5 PIEZO2 ZNF530 TMPRSS2	2.85e-05	166	158	6	8d5d09f25e8903d481c2097fed435e69d42ccdb5
ToppCell	Sigmoid-Macrophage-Macrophage\|Macrophage / Region, Cell class and subclass	CTTNBP2 TMEM176B SASH1 RNF149 SGPL1 LPAR6	3.04e-05	168	158	6	bb16e135b6ae0d66615420b61edd6f62f2a3233c
ToppCell	severe_influenza-pDC\|World / disease group, cell group and cell class (v2)	AZIN2 MCC KIRREL3 SLC35F3 ABCA6 IL3RA	3.25e-05	170	158	6	b9c08af83241666bbdbed9109cadcd088c0f647d
ToppCell	droplet-Marrow-nan-18m-Lymphocytic-plasma_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TMEM176B SASH1 TEP1 CD93 ADGRE1 PLXNA1	3.25e-05	170	158	6	067657ca7fcf5a0ffbd168b5c4609a30ca508f22
ToppCell	droplet-Marrow-BM_(NON-STC)-30m-Lymphocytic-plasma_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TMEM176B SASH1 PIGZ SLC10A6 ADGRE1 PLXNA1	3.47e-05	172	158	6	7295bf3ae21a61dd6bcfa0dfb7a37d0f3e8f94ab
ToppCell	severe_influenza-pDC\|severe_influenza / disease group, cell group and cell class (v2)	AZIN2 MCC KIRREL3 SLC35F3 ABCA6 IL3RA	3.71e-05	174	158	6	d8d2ded5812ed3b3db4109585714a6513c13326a
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Glomerular_Capillary_Endothelial_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	TBXA2R DSCAM TNFSF9 CD109 PIEZO2 HMCN2	3.95e-05	176	158	6	64e426f5e84884ce2c29acf6f4b958962a63927f
ToppCell	facs-Lung-nan-3m-Mesenchymal-fibroblast_of_lung\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MRC2 MAMDC2 FHOD1 SLC10A6 PRKG2 C7	4.76e-05	182	158	6	c557de6ccd327c46e0a5423cd9936d78e0abae5f
ToppCell	facs-Lung-nan-3m-Mesenchymal-Alveolar_Fibroblast\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MRC2 MAMDC2 FHOD1 SLC10A6 PRKG2 C7	4.76e-05	182	158	6	dbe4b2557cf19e0682ed446f8397d3a1153642f0
ToppCell	343B-Myeloid-Macrophage-M2-like_Macrophage_(MARCO_negative)\|343B / Donor, Lineage, Cell class and subclass (all cells)	TMEM176B HLA-DRB1 PRSS36 SLC12A5 CD93 LPAR6	5.21e-05	185	158	6	d4ba36bdb8b7e3a62e827269484f89f790eaa5ef
ToppCell	Children_(3_yrs)-Immune-interstitial_macrophage_(C1Q_positive)-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	TMEM176B RYR1 ABCA6 MAMDC2 LPAR6 ATG4C	5.21e-05	185	158	6	8207f9eff113eed429e961748c6b17d672a13b33
ToppCell	facs-Lung-EPCAM-18m-Mesenchymal-pulmonary_interstitial_fibroblast\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	WDR54 IRAG1 DDC OTOGL SLC9B2 SLC10A6	5.37e-05	186	158	6	aa88d9573a237b2b8e6025fee31f69fbce824497
ToppCell	343B-Myeloid-Macrophage-M2-like_Macrophage_(MARCO_negative)\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	TMEM176B HLA-DRB1 SLC12A5 CD93 MAMDC2 LPAR6	5.37e-05	186	158	6	9673367cb53bafb873a01ef6bda11d9f392ce648
ToppCell	facs-Lung-EPCAM-18m-Mesenchymal-Myofibroblast\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	WDR54 IRAG1 DDC OTOGL SLC9B2 SLC10A6	5.37e-05	186	158	6	ecc5acd111a6ee50d59544d1bdd7ed94e2812aae
ToppCell	5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Alveolar_fibroblasts-Alveolar_fibroblasts_L.2.1.1.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PIEZO2 ABCA6 MRC2 MAMDC2 NOTO C7	5.37e-05	186	158	6	5473283fb95cee556b1f6934cf72169b676b5bcc
ToppCell	facs-Lung-18m-Mesenchymal-myofibroblast-myofibroblast_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	WDR54 IRAG1 DDC OTOGL SLC9B2 SLC10A6	5.37e-05	186	158	6	26458ff8cad5577de4306cffa0ca69eb26940e0d
ToppCell	facs-Lung-18m-Mesenchymal-myofibroblast-myofibroblast_cell-pulmonary_interstitial_myofibroblast\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	WDR54 IRAG1 DDC OTOGL SLC9B2 SLC10A6	5.37e-05	186	158	6	a71397efc68d2916ddc373d92cfd07be58033e1c
ToppCell	facs-Large_Intestine-Distal-24m-Epithelial-intestinal_crypt_stem_cell\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CTTNBP2 TMEM176B PNLIPRP1 RNF149 DDC CSAD	5.37e-05	186	158	6	af038994a6c32261f426b0c40c39be4a9099fe43
ToppCell	droplet-Fat-SCAT-30m-Epithelial\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SZT2 PIEZO2 SLC35F3 P2RX2 OSBPL3 TMPRSS2	5.53e-05	187	158	6	5fada3c5a58c1890029ccbfff2608b33f8cd2df7
ToppCell	droplet-Fat-SCAT-30m-Epithelial-nan\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SZT2 PIEZO2 SLC35F3 P2RX2 OSBPL3 TMPRSS2	5.53e-05	187	158	6	766e808138fc2cd623c2e6d57fcb5c7378da0e03
ToppCell	droplet-Fat-SCAT-30m-Epithelial-epithelial_cell\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SZT2 PIEZO2 SLC35F3 P2RX2 OSBPL3 TMPRSS2	5.53e-05	187	158	6	f49d06600060deeb2fc1b1da5b93496535f20104
ToppCell	PCW_07-8.5-Endothelial-Endothelial_mature-endo_capillary_(2)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	TMEM176B HLA-DRB1 NTRK2 CD93 GDPD5 SLC35F3	5.53e-05	187	158	6	106f50ad85a92403037214f0e94702230284837f
ToppCell	wk_08-11-Endothelial-Blood_vessel_endothelial-GRIA2+_arterial_endo\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	NTRK2 CD93 GDPD5 SLC35F3 IL3RA IL27RA	5.53e-05	187	158	6	a27aa97aa6508a3ffe92c2b6bb0511a95650a390
ToppCell	COVID-19-lung-Vein_EC\|lung / Disease (COVID-19 only), tissue and cell type	SASH1 CD109 MCC PKHD1L1 CD93 SLC10A6	5.70e-05	188	158	6	d582b76fc2faac526c9bf97503041129e1a6a211
ToppCell	droplet-Pancreas-Exocrine-24m-Mesenchymal-pancreatic_stellate_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IRAG1 PIEZO2 ABCA6 MRC2 SLC10A6 C7	6.04e-05	190	158	6	8cb950effc449ae59a915132ecc079be54d1acfe
ToppCell	droplet-Pancreas-Exocrine-24m-Mesenchymal\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IRAG1 PIEZO2 ABCA6 MRC2 SLC10A6 C7	6.04e-05	190	158	6	5dfbd064ab1f8a0b18b5975c47f8e79697f3db15
ToppCell	droplet-Pancreas-Exocrine-24m-Mesenchymal-pancreatic_stellate_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IRAG1 PIEZO2 ABCA6 MRC2 SLC10A6 C7	6.04e-05	190	158	6	17a73a658fb30a4322b31e38db7b240023738f29
ToppCell	droplet-Lung-3m-Mesenchymal-fibroblast-alveolar_fibroblast\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	TMEM176B AOPEP MRC2 MAMDC2 FHOD1 PRKG2	6.22e-05	191	158	6	509230f50568e5a8ecf08edc4d58f9e2aa96efe9
ToppCell	droplet-Lung-immune-endo-depleted-3m-Mesenchymal-fibroblast_of_lung\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AOPEP MRC2 MAMDC2 FHOD1 PRKG2 C7	6.22e-05	191	158	6	a261f0738d974784bbdd60f23092bfbcca464459
ToppCell	facs-Lung-3m-Mesenchymal-fibroblast-alveolar_fibroblast\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	MRC2 MAMDC2 FHOD1 SLC10A6 PRKG2 C7	6.22e-05	191	158	6	beb5bb42bd53bce01339da9110d374901548793c
ToppCell	droplet-Lung-immune-endo-depleted-3m-Mesenchymal-Alveolar_Fibroblast\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AOPEP MRC2 MAMDC2 FHOD1 PRKG2 C7	6.22e-05	191	158	6	6594398cc8151c73696391a43ac110c10283dab1
ToppCell	facs-Lung-3m-Mesenchymal-fibroblast-alveolar_fibroblast-alveolar_fibroblast_l49\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	MRC2 MAMDC2 FHOD1 SLC10A6 PRKG2 C7	6.22e-05	191	158	6	6609d85fd2577633dcc067507304a6f9e5865ca3
ToppCell	droplet-Lung-1m-Mesenchymal-fibroblast-alveolar_fibroblast-alveolar_fibroblast_l49\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	AOPEP MRC2 MAMDC2 SLC10A6 PRKG2 C7	6.22e-05	191	158	6	de3e9b704621b26836c2ddc39fa3e840dfb4541b
ToppCell	droplet-Lung-3m-Mesenchymal-fibroblast-alveolar_fibroblast-alveolar_fibroblast_l49\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	TMEM176B AOPEP MRC2 MAMDC2 FHOD1 PRKG2	6.22e-05	191	158	6	0b3dbbc35d9970d3c749aef16dda59886b960e3d
ToppCell	facs-Large_Intestine-Distal-3m-Epithelial-intestinal_crypt_stem_cell\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CTTNBP2 RNF149 MCC PPAT DDC CSAD	6.22e-05	191	158	6	7411b253b16e4d472be0925dee49188f0fd6b0b5
ToppCell	Globus_pallidus-Macroglia-OLIGODENDROCYTE-O1\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	C10orf90 SSPOP PIGZ ARSG ABCA6	6.37e-05	118	158	5	d0dd5c882cd9e0a5eb0cb08e47877292126bd4ae
ToppCell	Globus_pallidus-Macroglia-OLIGODENDROCYTE-O1-Trf\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	C10orf90 SSPOP PIGZ ARSG ABCA6	6.37e-05	118	158	5	4283699cb3ca7a112faa07727dfdc0b0a67fb779
ToppCell	LA\|World / Chamber and Cluster_Paper	IRAG1 KIRREL3 HMCN2 ABCA6 MRC2 MAMDC2	6.59e-05	193	158	6	d4bf89437216baf489ea0239136dcedf3b6714af
ToppCell	PCW_13-14-Endothelial-Endothelial_mature-endo_capillary_(2)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	NTRK2 CD109 CD93 GDPD5 KIRREL3 SLC35F3	6.78e-05	194	158	6	3c31ac44e8cf4eca3ba7b8bfc05ad3e96a970956
ToppCell	Fetal_29-31_weeks-Mesenchymal-matrix_fibroblast_1_cell\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	CTTNBP2 CSMD3 PIEZO2 ABCA6 MRC2 C7	6.78e-05	194	158	6	011e14d9ed1393275f892060e7708ffadcd0767f
ToppCell	COVID-19-Heart-Fib_2\|Heart / Disease (COVID-19 only), tissue and cell type	AZIN2 KIRREL3 HMCN2 ABCA6 MRC2 C7	6.78e-05	194	158	6	d91c9f2ec47319051fc398320693fddbe8bbd4d6
ToppCell	distal-1-Hematologic-IGSF21+_Dendritic\|1 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	TMEM176B HLA-DRB1 SLC12A5 CD93 MAMDC2 LPAR6	6.78e-05	194	158	6	f30c866e5f41ee79bdc6b6e08af962d62b199835
ToppCell	368C-Myeloid-Macrophage-M2-like_Macrophage_(MARCO_negative)\|Macrophage / Donor, Lineage, Cell class and subclass (all cells)	TMEM176B IRAG1 SLC12A5 CD93 MAMDC2 LPAR6	6.78e-05	194	158	6	58046894446cb250814252a23f60fdd59c114d77
ToppCell	PCW_05-06-Endothelial-Endothelial_mature\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	TBXA2R TMEM176B CD109 CD93 GDPD5 IL3RA	6.98e-05	195	158	6	54fde2cfa51ab3a2d48d2426494ca6f0ce77f725
ToppCell	Smart-seq2-spleen_(Smart-seq2)-myeloid-myeloid_granulocytic-neutrophil\|spleen_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	NTRK2 LAMA1 MUC19 CSMD2 HMCN2 OTOGL	6.98e-05	195	158	6	d3755929ebbbf5e3afde44281e9056ddb614a291
ToppCell	3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.2.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PIEZO2 ABCA6 P2RX2 MRC2 MAMDC2 C7	6.98e-05	195	158	6	f54bc4454270ff06e85596f98199372b50d0179f
ToppCell	Smart-seq2-spleen_(Smart-seq2)-myeloid-myeloid_granulocytic\|spleen_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	NTRK2 LAMA1 MUC19 CSMD2 HMCN2 OTOGL	6.98e-05	195	158	6	19853c654ac64b3ae3bc99841c6cb29c8aaba85c
ToppCell	facs-Large_Intestine-Distal-18m-Epithelial-intestinal_crypt_stem_cell\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CTTNBP2 PPAT DDC AOPEP CSAD SCPEP1	6.98e-05	195	158	6	44ac99e33b20a377009b8fef16142050a3e1da51
ToppCell	LA-02._Fibroblast_II\|World / Chamber and Cluster_Paper	KIRREL3 HMCN2 ABCA6 MRC2 MAMDC2 C7	6.98e-05	195	158	6	a78b605b49acd8c9d68716266ca269dafcd910b9
ToppCell	PCW_10-12-Endothelial-Endothelial_mature-endo_capillary_(2)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	NTRK2 CD109 CD93 GDPD5 KIRREL3 SLC35F3	7.18e-05	196	158	6	2a2a93b89dcb98043cb1f8b422ac8c55e2edc37b
ToppCell	10x5'-GI_small-bowel-Myeloid_Mac-Intestinal_macrophages\|GI_small-bowel / Manually curated celltypes from each tissue	CTTNBP2 TMEM176B SASH1 HLA-DRB1 CD93 MRC2	7.18e-05	196	158	6	075e5746fa5cb121115a1d51b823c0fbf8d54305
ToppCell	normal_Lung-Myeloid_cells-mo-Mac\|normal_Lung / Location, Cell class and cell subclass	TMEM176B HLA-DRB1 SLC12A5 CD93 MAMDC2 LPAR6	7.18e-05	196	158	6	4d3a3264b3d781139899448cde3b7a4f214ca14d
ToppCell	ICU-NoSEP-Myeloid-CD16_Mono\|ICU-NoSEP / Disease, Lineage and Cell Type	WSB1 TMEM176B HLA-DRB1 INSIG1 ADGRE1 IL3RA	7.18e-05	196	158	6	b15abb1c5396d038bab92b048795020199370f44
ToppCell	BLOOD--(3)_Non_classical_monocytes\| / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	TMEM176B HLA-DRB1 INSIG1 KLK3 ADGRE1 IL3RA	7.18e-05	196	158	6	b5ce99e27c9e87be52c10c022a665bf4df0e8b05
ToppCell	Multiple_Sclerosis-Myeloid-CD16_Mono\|Multiple_Sclerosis / Disease, Lineage and Cell Type	TMEM176B HLA-DRB1 INSIG1 RNF149 ADGRE1 IL3RA	7.18e-05	196	158	6	83011b56780295dff5ded57064b07dcd2f19ea26
ToppCell	5'-GW_trimst-2-LargeIntestine-Hematopoietic-Myeloid-Macrophages\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CTTNBP2 SASH1 HLA-DRB1 RYR1 SGPL1 LPAR6	7.38e-05	197	158	6	10190b877bf46ba2163d203df9dd3b498c66e52f
ToppCell	systemic_lupus_erythematosus-treated-Myeloid-non-classical_monocyte-female\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	WSB1 INSIG1 RNF149 LPAR6 ADGRE1 IL3RA	7.38e-05	197	158	6	46d8c7e9b3aff70bc58894282d0ec9e87d37235f
ToppCell	systemic_lupus_erythematosus-treated-Myeloid-non-classical_monocyte\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	WSB1 INSIG1 RNF149 LPAR6 ADGRE1 IL3RA	7.38e-05	197	158	6	1a82e0e74fc5fd71c490d98e8813d719b0b81aa6
ToppCell	distal-3-Hematologic-IGSF21+_Dendritic\|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	TMEM176B HLA-DRB1 SLC12A5 CD93 MAMDC2 LPAR6	7.38e-05	197	158	6	52e9dc35dd8cc2605fa4894bb16bb5c6086faa76
ToppCell	ILEUM-inflamed-(3)_MNP-(3)_Resident_macrophages\|(3)_MNP / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	CTTNBP2 TMEM176B SASH1 HLA-DRB1 LPAR6 SCPEP1	7.59e-05	198	158	6	30bf78d4d657cf5140549d3dbf43d4f00482e300
ToppCell	distal-1-mesenchymal-Alveolar_Fibroblast\|1 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	TMEM176B PKD1L2 ABCA6 MAMDC2 NOTO C7	7.59e-05	198	158	6	6594c35ab203dc51462167c61807b0d49fa30fb2
ToppCell	proximal-mesenchymal-Alveolar_Fibroblast\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	TMEM176B PIEZO2 ABCA6 MRC2 MAMDC2 C7	7.80e-05	199	158	6	7f4840ae6a888380feca722543e5e52783f3e35d
ToppCell	distal-mesenchymal-Alveolar_Fibroblast-2\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	TMEM176B PIEZO2 ABCA6 MRC2 MAMDC2 C7	7.80e-05	199	158	6	28c1722deef3b8347371c7359be7c64b95780de3
ToppCell	proximal-3-mesenchymal-Alveolar_Fibroblast\|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	TMEM176B PIEZO2 ABCA6 MRC2 MAMDC2 C7	7.80e-05	199	158	6	301d02bbb37e6f1d24b6e865bc3fe3e91260eb30
ToppCell	5'-GW_trimst-2-LargeIntestine-Hematopoietic-Myeloid\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RASGRP4 CTTNBP2 HLA-DRB1 RYR1 SGPL1 LPAR6	7.80e-05	199	158	6	f34c15df58fbdc6c90e30800e26fabbf828ad10b
ToppCell	Parenchymal-NucSeq-Endothelial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	SASH1 NTRK2 CD109 PKHD1L1 CD93 SHC2	7.80e-05	199	158	6	a4a9a1c2a34b5a8318a55d1211d6c8661ca9793e
ToppCell	Parenchymal-NucSeq-Endothelial-Endothelia_vascular\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	SASH1 NTRK2 CD109 MCC CD93 SHC2	7.80e-05	199	158	6	d58edc5f74970bb26d844746184e4bae7c494d6b
Computational	Genes in the cancer module 445.	ACHE DDC GUCY2F GUCY2D	5.59e-06	15	89	4	MODULE_445
Computational	Genes in the cancer module 27.	EPOR NTRK2 ADGRB2 MCC RYR1 BRS3 LPAR6 TMPRSS2 ADGRE1 IL3RA IL27RA	1.59e-04	355	89	11	MODULE_27
Drug	U0125; Up 200; 1uM; PC3; HG-U133A	EPOR PNLIPRP1 ACOT9 PIGZ XYLT2 SHC2 MRC2 GLS SIK2 PRKG2	1.11e-06	196	157	10	663_UP
Disease	chronic kidney disease, APOL1 risk genotype carrier status	OTOGL LPA PLG	1.41e-06	5	155	3	EFO_0003884, EFO_0009324
Disease	aspirin-induced respiratory disease (is_implicated_in)	TBXA2R HLA-DRB1 HLA-DRB3	2.27e-05	11	155	3	DOID:0080822 (is_implicated_in)
Disease	cholesteryl esters to total lipids in medium LDL percentage	HLA-DRB1 IGF2R LPA PLG	4.23e-05	37	155	4	EFO_0022252
Disease	cholesterol in small LDL measurement	HLA-DRB1 IGF2R ABCA6 LPA	1.29e-04	49	155	4	EFO_0022227
Disease	phospholipids in medium VLDL measurement	HLA-DRB1 IGF2R ABCA6 LPA	1.63e-04	52	155	4	EFO_0022154
Disease	triglycerides in LDL measurement	HLA-DRB1 IGF2R LPA PLG	2.18e-04	56	155	4	EFO_0022320
Disease	free cholesterol to total lipids in large HDL percentage	SLC12A5 ABCA6 LPA PLG	2.18e-04	56	155	4	EFO_0022279
Disease	triglycerides to total lipids in small LDL percentage	HLA-DRB1 ABCA6 LPA PLG	2.66e-04	59	155	4	EFO_0022337
Disease	plasma plasminogen measurement	LPA PLG	2.71e-04	5	155	2	EFO_0006309
Disease	triglycerides in medium LDL measurement	HLA-DRB1 IGF2R LPA PLG	3.22e-04	62	155	4	EFO_0022322
Disease	cholesterol to total lipids in medium VLDL percentage	HLA-DRB1 ABCA6 LPA PLG	3.43e-04	63	155	4	EFO_0022239
Disease	cholesteryl esters to total lipids in medium VLDL percentage	HLA-DRB1 ABCA6 LPA PLG	3.64e-04	64	155	4	EFO_0022253
Disease	angiostatin measurement	LPA PLG	4.06e-04	6	155	2	EFO_0008024
Disease	extranodal nasal NK/T cell lymphoma	HLA-DRB1 HLA-DRB3	4.06e-04	6	155	2	MONDO_0019472
Disease	cholesterol to total lipids in very small VLDL percentage	HLA-DRB1 ABCA6 LPA PLG	4.34e-04	67	155	4	EFO_0022245
Disease	triglycerides to total lipids in very small VLDL percentage	HLA-DRB1 ABCA6 LPA PLG	4.86e-04	69	155	4	EFO_0022341
Disease	lipoprotein A measurement, apolipoprotein A 1 measurement	LPA PLG	5.66e-04	7	155	2	EFO_0004614, EFO_0006925
Disease	free cholesterol to total lipids in large LDL percentage	HLA-DRB1 ABCA6 LPA PLG	6.33e-04	74	155	4	EFO_0022280
Disease	stem Cell Growth Factor beta measurement	INSIG1 KLK3 PIEZO2 PNLIPRP3	6.66e-04	75	155	4	EFO_0008292
Disease	free cholesterol to total lipids in small VLDL percentage	HLA-DRB1 ABCA6 LPA PLG	6.66e-04	75	155	4	EFO_0022287
Disease	insulin like growth factor measurement	KIRREL3 C7	7.52e-04	8	155	2	EFO_0004628
Disease	myasthenia gravis (is_implicated_in)	ACHE HLA-DRB1	7.52e-04	8	155	2	DOID:437 (is_implicated_in)
Disease	chylomicron measurement, triglycerides:total lipids ratio, very low density lipoprotein cholesterol measurement	HLA-DRB1 LPA PLG	7.55e-04	34	155	3	EFO_0008317, EFO_0008596, EFO_0020947
Disease	monounsaturated fatty acids; 16:1, 18:1 measurement	HLA-DRB1 IGF2R LPA PLG	7.72e-04	78	155	4	EFO_0022187
Disease	Schizophrenia	ACSL6 ACHE HLA-DRB1 NTRK2 LAMA1 CSMD2 TRRAP SLC12A5 ZNF530 PLG ATP2A2 IL3RA TAPBP	8.14e-04	883	155	13	C0036341
Disease	Kunitz-type protease inhibitor 2 measurement	RASGRP4 RYR1	1.20e-03	10	155	2	EFO_0008200
Disease	sleep duration, low density lipoprotein cholesterol measurement	IGF2R LPA PLG QTRT1	1.37e-03	91	155	4	EFO_0004611, EFO_0005271
Disease	cholesteryl esters to total lipids in small LDL percentage	HLA-DRB1 LPA PLG	1.40e-03	42	155	3	EFO_0022255
Disease	chylomicron measurement, very low density lipoprotein cholesterol measurement, free cholesterol:total lipids ratio	HLA-DRB1 LPA PLG	1.40e-03	42	155	3	EFO_0008317, EFO_0008596, EFO_0020945
Disease	free cholesterol to total lipids in very small VLDL percentage	ABCA6 LPA PLG	1.50e-03	43	155	3	EFO_0022290
Disease	Adenocarcinoma of large intestine	MCC TRRAP ARAF PRKG2	1.67e-03	96	155	4	C1319315
Disease	temporal arteritis	HLA-DRB1 PLG	1.75e-03	12	155	2	EFO_1001209
Disease	Connective Tissue Diseases	SLC39A13 PIEZO2	2.06e-03	13	155	2	C0009782
Disease	phospholipids in medium LDL measurement	HLA-DRB1 IGF2R ABCA6	2.19e-03	49	155	3	EFO_0022183
Disease	cholesterol in medium LDL measurement	HLA-DRB1 IGF2R ABCA6	2.19e-03	49	155	3	EFO_0022224
Disease	cholesteryl esters to total lipids in small VLDL percentage	HLA-DRB1 ABCA6 LPA	2.19e-03	49	155	3	EFO_0022256
Disease	GDH/6PGL endoplasmic bifunctional protein measurement	HLA-DRB1 OVCH1	2.39e-03	14	155	2	EFO_0801619
Disease	familial hyperlipidemia	HLA-DRB1 IGF2R LPA ATG4C	2.40e-03	106	155	4	MONDO_0001336
Disease	polyunsaturated fatty acids to monounsaturated fatty acids ratio	HLA-DRB1 LPA PLG	2.46e-03	51	155	3	EFO_0022302
Disease	remnant cholesterol measurement	HLA-DRB1 IGF2R ABCA6 LPA	2.57e-03	108	155	4	EFO_0010815
Disease	total lipids in medium LDL	HLA-DRB1 IGF2R ABCA6	2.60e-03	52	155	3	EFO_0022180
Disease	total lipids in LDL measurement	HLA-DRB1 IGF2R ABCA6	2.60e-03	52	155	3	EFO_0022308
Disease	Autistic Disorder	HLA-DRB1 NTRK2 TAF1C MCC CSMD3 TRRAP	2.64e-03	261	155	6	C0004352
Disease	triglycerides in HDL measurement	HLA-DRB1 LPA PLG	2.75e-03	53	155	3	EFO_0022317
Disease	cholesterol in small VLDL measurement	HLA-DRB1 IGF2R ABCA6	2.75e-03	53	155	3	EFO_0022228
Disease	free cholesterol to total lipids in small LDL percentage	HLA-DRB1 LPA PLG	2.75e-03	53	155	3	EFO_0022286
Disease	total lipids in medium VLDL	HLA-DRB1 IGF2R LPA	2.90e-03	54	155	3	EFO_0022153
Disease	peripheral arterial disease	HLA-DRB1 CSMD3 LPA	2.90e-03	54	155	3	EFO_0004265
Disease	triglycerides in medium HDL measurement	HLA-DRB1 LPA PLG	2.90e-03	54	155	3	EFO_0022321
Disease	cholesterol to total lipids in very large VLDL percentage	HLA-DRB1 ABCA6 LPA	2.90e-03	54	155	3	EFO_0022244
Disease	lipoprotein A measurement	IGF2R ABCA6 LPA PLG	2.93e-03	112	155	4	EFO_0006925
Disease	free cholesterol measurement	HLA-DRB1 IGF2R ABCA6 LPA	3.03e-03	113	155	4	EFO_0008591
Disease	linoleic acid measurement	HLA-DRB1 IGF2R ABCA6 LPA PLG	3.08e-03	186	155	5	EFO_0006807
Disease	total cholesterol measurement, low density lipoprotein cholesterol measurement	HLA-DRB1 IGF2R ABCA6 LPA	3.12e-03	114	155	4	EFO_0004574, EFO_0004611
Disease	triglycerides to total lipids in medium HDL percentage	HLA-DRB1 LPA PLG	3.21e-03	56	155	3	EFO_0022333
Disease	cholesteryl esters to total lipids in medium HDL percentage	HLA-DRB1 LPA PLG	3.21e-03	56	155	3	EFO_0022251
Disease	phospholipids in VLDL measurement	HLA-DRB1 IGF2R LPA	3.73e-03	59	155	3	EFO_0022301
Disease	free cholesterol to total lipids in very large VLDL percentage	HLA-DRB1 ABCA6 LPA	3.73e-03	59	155	3	EFO_0022289
Disease	triglycerides to total lipids in large HDL percentage	HLA-DRB1 LPA PLG	3.91e-03	60	155	3	EFO_0022330
Disease	total lipids in VLDL measurement	HLA-DRB1 IGF2R LPA	3.91e-03	60	155	3	EFO_0022314
Disease	cholesterol to total lipids in medium HDL percentage	HLA-DRB1 LPA PLG	3.91e-03	60	155	3	EFO_0022237
Disease	omega-6 polyunsaturated fatty acid measurement	HLA-DRB1 IGF2R ABCA6 LPA PLG	3.93e-03	197	155	5	EFO_0005680
Disease	essential hypertension (is_implicated_in)	REN ATP2A2	3.97e-03	18	155	2	DOID:10825 (is_implicated_in)
Disease	Colorectal Carcinoma	LAMA1 CD109 MCC CSMD3 SLC12A5 CD93 ABCB10 ABCA6 ACSL5 HDC	4.09e-03	702	155	10	C0009402
Disease	triglycerides in small VLDL measurement	HLA-DRB1 LPA PLG	4.09e-03	61	155	3	EFO_0022145
Disease	free cholesterol in IDL measurement	ABCA6 LPA PLG	4.09e-03	61	155	3	EFO_0022181
Disease	free cholesterol in VLDL measurement	HLA-DRB1 IGF2R LPA	4.09e-03	61	155	3	EFO_0022276
Disease	triglycerides in small HDL measurement	HLA-DRB1 LPA PLG	4.29e-03	62	155	3	EFO_0022158
Disease	phospholipids in large VLDL measurement	HLA-DRB1 LPA PLG	4.29e-03	62	155	3	EFO_0022169
Disease	triglycerides to total lipids in very large HDL percentage	HLA-DRB1 LPA PLG	4.29e-03	62	155	3	EFO_0022339
Disease	free cholesterol in very large HDL measurement	SLC12A5 LPA PLG	4.29e-03	62	155	3	EFO_0022273
Disease	hepatitis B virus infection	HLA-DRB1 HLA-DRB3	4.42e-03	19	155	2	EFO_0004197
Disease	toxic shock syndrome (is_marker_for)	HLA-DRB1 REN	4.42e-03	19	155	2	DOID:14115 (is_marker_for)
Disease	cholesteryl ester measurement, low density lipoprotein cholesterol measurement	HLA-DRB1 IGF2R ABCA6 LPA	4.46e-03	126	155	4	EFO_0004611, EFO_0010351
Disease	triglycerides to total lipids in medium VLDL percentage	ABCA6 LPA PLG	4.48e-03	63	155	3	EFO_0022335
Disease	free cholesterol to total lipids in medium LDL percentage	HLA-DRB1 LPA PLG	4.48e-03	63	155	3	EFO_0022283
Disease	parental longevity	CTTNBP2 HLA-DRB1 ADGRB2 PKD1L2 IGF2R LPA PLG SLC14A2	4.72e-03	494	155	8	EFO_0007796
Disease	triglycerides in small LDL measurement	HLA-DRB1 LPA PLG	4.89e-03	65	155	3	EFO_0022323
Disease	cholesterol in large VLDL measurement	HLA-DRB1 IGF2R LPA	4.89e-03	65	155	3	EFO_0021902
Disease	cholesterol in very large VLDL measurement	HLA-DRB1 IGF2R LPA	4.89e-03	65	155	3	EFO_0022230
Disease	ulcerative colitis, Crohn's disease	ATG16L1 HLA-DRB1	4.90e-03	20	155	2	EFO_0000384, EFO_0000729

Protein segments in the cluster

Peptide	Gene	Start	Entry
PWSGVVDATTFQSVC	ACHE	86	P22303
DLFPTIASGCSWTLE	ADGRB2	56	O60241
LPAVFTCEGNGSWTG	CSMD2	3046	Q7Z408
SFPAVLTCVGNGTWS	CSMD3	3266	Q7Z407
GPASLARWTLGFCDE	PGLS	66	O95336
FSAPGFKCGSDWTRV	ATG16L1	526	Q676U5
GWEITDTLCVGPVFT	AZIN2	441	Q96A70
GQVWAPEGSTAFKCL	ALG9	51	Q9H6U8
EWILNICSPFAFTTG	ABCA6	356	Q8N139
GERTAPFCSWFQGVL	B3GALT4	351	O96024
DVFDWGSSGPLCVSP	CD93	246	Q9NPY3
WPCFLLTSVGTGLAS	COX10	186	Q12887
ELAWATACSFGGSRP	ACOT9	321	Q9Y305
VACVWAAASRVPGSL	ABCB10	26	Q9NRK6
WAQKCELAGSVGPFT	ARSG	306	Q96EG1
QAPGCGELLFDTDTW	AOPEP	211	Q8N6M6
GAIGCIGFSWAASPA	DDC	96	P20711
IGFSWAASPACTELE	DDC	101	P20711
GDGVCVTFWRSSPLD	BBS12	466	Q6ZW61
GLCSAFISAVWVAFP	ERMP1	546	Q7Z2K6
PQIEGSALTTDCGWG	ATG4C	96	Q96DT6
GCWFFTSGPVSLSAK	ARRDC4	186	Q8NCT1
VLGNPSWTVGCSVDV	RABL3	31	Q5HYI8
FSPDLWGVSVCTVDG	GLS	256	O94925
STCGFDSVLASLPWI	MAMDC2	31	Q7Z304
SSTGRPDWTCIVVGF	RAB3GAP2	146	Q9H2M9
ADAINCLGFTWASSP	HDC	96	P19113
GCFKDGLPWTRTFST	PNLIPRP3	26	Q17RR3
ATFAITTLWLGPCDI	HHATL	371	Q9HCP6
GGDLESLCPWESTDF	GPR179	1421	Q6PRD1
SAVFTVGVLGPWACD	GUCY2D	51	Q02846
LCSFLPWSGISSKSG	NAA60	221	Q9H7X0
AGADVELQCWTSGVP	HMCN2	1451	Q8NDA2
APRSFIFLWCGSGEG	METTL14	226	Q9HCE5
EPGAVTGSATVTAFW	ASPDH	251	A6ND91
RGCIWEASNSSGVPF	MGAM	981	O43451
ISPACGAQASWSIFG	IRAG1	11	Q9Y6F6
DVAVSVGGRPCSFSW	PLXNA1	991	Q9UIW2
GCFSDTEPWGGTAIR	PNLIPRP1	26	P54315
GLESVQCWIGIPFSA	OR52A5	21	Q9H2C5
LCASDGPGTFESWRS	MUC19	696	Q7Z5P9
WGAEAVGCSIQLTTP	PGLYRP4	61	Q96LB8
PTFCDSCSGFLWGVT	RASGRP4	551	Q8TDF6
SWLPCIFFSGGVTVG	INSIG1	246	O15503
PAFWTAASLCATGGL	NOTO	76	A8MTQ0
CSLIPSGAEWARVSA	IL27RA	286	Q6UWB1
WGPAPVFVTSLEACV	MEGF8	661	Q7Z7M0
TTALGGCPSDWIQFL	MRC2	966	Q9UBG0
SWGDAPTEVVACSGS	KIF26A	1321	Q9ULI4
LFSLLWCAGVPSVTS	GDPD5	461	Q8WTR4
PTFCSHCTDFIWGIG	PRKCG	46	P05129
VCTGVWLTVIGGSAP	LPAR6	136	P43657
VVSWCTGVSTGFLPS	OR11L1	146	Q8NGX0
VASLPETAWGCQGSI	NEU4	266	Q8WWR8
ETAWGCQGSIVGFPA	NEU4	271	Q8WWR8
IGSGQKTWTFCGTPE	PRKG2	601	Q13237
IGRGPSSEWVTSDCA	PKD1L2	131	Q7Z442
WAEGCFPLLESGDST	NUTM1	836	Q86Y26
ICGGSLIAPSWVLSA	PRSS36	71	Q5K4E3
EVFGWCPVEDGASVS	P2RX2	171	Q9UBL9
CFTATFEIWVEGPLG	BECN2	251	A8MW95
STCWGLSFVVPGAIV	SLC37A1	216	P57057
CSVSGFYPGSIEVRW	HLA-DRB3	146	P79483
FPSGSECHISGWGVT	HABP2	441	Q14520
PGFAIITQWCEGSSL	ARAF	376	P10398
SFSACTDGISWPFVL	ATP2A2	1006	P16615
DPSGSTWLSAFVLRC	CD109	981	Q6YHK3
GAFAVAGCSVQPWES	MCC	526	P23508
WFIAVSSEGGCPLIL	IL36A	126	Q9UHA7
DVDFLSCSWAVGPGA	IL3RA	116	P26951
WGETSDGTLFCPRDA	C2CD3	66	Q4AC94
CAVSALATSQVGAWP	CTTNBP2	626	Q8WZ74
GVVGPWACDSLFSKA	GUCY2F	56	P51841
EGPSAFLCGSSLKWS	C7	666	P10643
PEAASWLLCEVSGFS	IGHD	286	P01880
CSVSGFYPGSIEVRW	HLA-DRB1	146	P01911
TECTGGCTFTLPGDW	ACSL5	446	Q9ULC5
GCTFTLPGDWTSGHV	ACSL5	451	Q9ULC5
QKFTGAVCWSGPAST	ANGPTL6	36	Q8NI99
FGKHFCGGTLISPEW	LPA	1841	P08519
CGGTLISPEWVLTAA	LPA	1846	P08519
FTANPWICISGELGE	DENND5A	971	Q6IQ26
GGLSSPEFSELCIWL	FAM98B	41	Q52LJ0
RALVGWSSGDGIFCP	CSAD	136	Q9Y600
SVWFGPKEVSTACAT	FLVCR1	226	Q9Y5Y0
SVGTNCGIEPWDSGV	CEP192	1351	Q8TEP8
VTVWTCPTVSRSGGF	CDC20B	471	Q86Y33
VCFWEEAASAGVGPG	EPOR	61	P19235
GAVRFWCSLPTADTS	EPOR	101	P19235
DAIFSCAWTGNPSLT	KIRREL3	351	Q8IZU9
SPWGCLVGTLTLAAF	DCST2	51	Q5T1A1
GVSASRFGPCATLWA	FHOD1	641	Q9Y613
DSQPCVLGWESFASG	BTN2A2	366	Q8WVV5
VVGCSPAAEETAAWV	SLC39A13	306	Q96H72
VRVFAGQEPSCVWAG	RYR1	1436	P21817
CLPTGWANFGVTSEE	RYR1	2656	P21817
GVWTGETIPVRTCFG	PRDM4	426	Q9UKN5
RVFGDSWALGQCESP	OTOGL	1101	Q3ZCN5
FSCGGETRVPLWLQS	OSBPL3	201	Q9H4L5
LGSWVCGFVAIAVPT	OR6F1	146	Q8NGZ6
SPWVIVIGSFFSTCG	SLC12A5	506	Q9H2X9
SIFWLGAREITFPGC	OR52H1	91	Q8NGJ2
LIGWNDGGCPITSFT	DSCAM	1496	O60469
SWYTSAVCPLGVGFD	IGF2R	2271	P11717
AWFPGSGAFRELVSC	SARS1	381	P49591
FVPGHFSCDVVWGTV	SZT2	2031	Q5T011
LPSDLLSWSCVGAVG	SLC35G3	246	Q8N808
PFGFALEAGCQAWDT	SUPT20HL1	336	Q3ZLR7
LCPTWATDALASVGI	QTRT1	386	Q9BXR0
SWRLPGSESGCLDAV	SSPOP	351	A2VEC9
CNFAGVALGDSWISP	SCPEP1	191	Q9HB40
SRSGAVCLWSPEDGL	TAF1C	356	Q15572
TSWVAGCAGGSVPVR	OVCH1	256	Q7RTY7
PLFSSEICAVTGWGS	OVCH1	691	Q7RTY7
LWGSCTFGLPTDTTT	REN	16	P00797
FGVSDVCSSLSWPVG	LAMA1	506	P25391
PVSTGRFKGCSVSLW	EPPK1	1456	P58107
VWSITGSECLPGGNL	SLC9B2	101	Q86UD5
WALAACFTPGESQRG	SMR3B	11	P02814
FFKSGELLATWCGSP	SIK2	166	Q9H0K1
FCGGTLISPEWVLTA	PLG	606	P00747
RPSVCIGTVVFSWVG	OR6J1	136	Q8NGC5
SFDDIPWGNLCGFSV	SLC35F3	296	Q8IY50
SLGPWTVLSASGCAF	TMEM176B	86	Q3YBM2
SRDIFPVGWCSLTGD	SCMH1	216	Q96GD3
TIAGSRPGGISAACW	SGPL1	391	O95470
GSTDIPDWCVVEAGF	APEH	621	P13798
WSGDNSPGIEALCAI	BRS3	36	P32247
TETGFIWSFLGPVCT	ADGRE1	746	Q14246
TECTAGCTFTTPGDW	ACSL6	461	Q9UKU0
LGTDITVICPWEAFS	PDE6H	56	Q13956
ARALVWGTAGDSLCP	C10orf90	151	Q96M02
LVVGFWRAAFACPTS	NTRK2	21	Q16620
SRIWCSDPSPGIVAF	NTRK2	41	Q16620
VITWGRGFACVSPGE	ERVK-25	826	P63136
LPSDLLSWSCVGAVG	SLC35G4	246	P0C7Q5
AAPWVALVARGGCTF	RNF149	106	Q8NC42
SCPQGSWAFSVSLGE	TBC1D17	111	Q9HA65
CGGSIITPEWIVTAA	TMPRSS2	281	O15393
LISCSSDGSVGLWDP	TEP1	2121	Q99973
SGWALTFAPTLACLS	SLC16A13	116	Q7RTY0
LRDACSLPWDVGSTG	SHC2	376	P98077
TAVSAGPAVIECWFV	TAPBP	16	O15533
GPAVIECWFVEDASG	TAPBP	21	O15533
WALAACFTPGESQRG	SMR3A	11	Q99954
IATLECSWTLPSLGG	GEMIN5	366	Q8TEQ6
ECGVFGCIASGEWPT	PPAT	11	Q06203
PSGEAGIIWDSICFA	PIEZO2	1406	Q9H5I5
VTWITKSFCPGGTDS	UBE2O	306	Q9C0C9
PGCISSVSDWLISIG	SASH1	1176	O94885
CPGGTISNIFTFWVD	SLC10A6	106	Q3KNW5
EAEWSIGFPGSVCDA	PKHD1L1	2826	Q86WI1
VAAGTSFQVLGPVCW	PIGZ	11	Q86VD9
AVFLACPWAVSGARA	TNFSF9	46	P41273
GAIPIEGATEWSDCF	THUMPD3	331	Q9BV44
FSWTIPIAVALSCFG	SLC7A6	316	Q92536
VDLCAAPGSWSQVLS	FTSJ1	46	Q9UET6
ACSAGDTWASEVGPV	TMEM19	181	Q96HH6
TACGLPDVAVSWGLD	ZZEF1	1191	O43149
SEGGFSLCHPGWSVV	TPTE2P1	101	Q5T6R2
WCGAVDEGTPSAESV	ZNF530	56	Q6P9A1
VITWGRGFACVSPGE	ERVK-19	831	Q9WJR5
ASPWFAASFCVVGLA	TBXA2R	26	P21731
CGDIVWSLAFGSSVP	WSB1	106	Q9Y6I7
FASFPEGSWEACGSL	PVRIG	136	Q6DKI7
CDNPWTGGVFLVALF	SLC14A2	296	Q15849
SVVGVPPGTWAFCLA	SLC14A2	391	Q15849
TWGITSCKAPGEAQF	TRRAP	561	Q9Y4A5
LSSFWSVAGLCAIGP	XYLT2	816	Q9H1B5
TADDSGLLCVWRSGP	WDR54	186	Q9H977
ITWCFLESPLEVSSG	nan	11	Q8N3U1
GVLQGITSWGSEPCA	KLK3	221	P07288