Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionhistone H4K16 acetyltransferase activity

JADE2 JADE1

2.16e-059162GO:0046972
GeneOntologyMolecularFunctionhistone H3K14 acetyltransferase activity

JADE2 JADE1

2.16e-059162GO:0036408
GeneOntologyMolecularFunctionhistone H4K8 acetyltransferase activity

JADE2 JADE1

3.30e-0511162GO:0043996
GeneOntologyMolecularFunctionhistone H4K5 acetyltransferase activity

JADE2 JADE1

3.30e-0511162GO:0043995
GeneOntologyMolecularFunctionhistone H4K12 acetyltransferase activity

JADE2 JADE1

3.95e-0512162GO:0043997
GeneOntologyMolecularFunctionhistone H3 acetyltransferase activity

JADE2 JADE1

6.28e-0515162GO:0010484
GeneOntologyMolecularFunctionhistone H4 acetyltransferase activity

JADE2 JADE1

1.51e-0423162GO:0010485
GeneOntologyMolecularFunctionsialic acid binding

SIGLEC14 SIGLEC5

1.79e-0425162GO:0033691
GeneOntologyMolecularFunctionhistone acetyltransferase activity

JADE2 JADE1

7.50e-0451162GO:0004402
GeneOntologyMolecularFunctionpeptide-lysine-N-acetyltransferase activity

JADE2 JADE1

8.72e-0455162GO:0061733
GeneOntologyMolecularFunctionpeptide N-acetyltransferase activity

JADE2 JADE1

1.04e-0360162GO:0034212
GeneOntologyMolecularFunctionN-acetyltransferase activity

JADE2 JADE1

1.74e-0378162GO:0008080
GeneOntologyMolecularFunctioncarbohydrate binding

SIGLEC14 SIGLEC5 PKD1

1.79e-03310163GO:0030246
GeneOntologyMolecularFunctionmonosaccharide binding

SIGLEC14 SIGLEC5

2.57e-0395162GO:0048029
GeneOntologyMolecularFunctionN-acyltransferase activity

JADE2 JADE1

2.96e-03102162GO:0016410
GeneOntologyMolecularFunctionacetyltransferase activity

JADE2 JADE1

3.07e-03104162GO:0016407
GeneOntologyCellularComponentficolin-1-rich granule membrane

SIGLEC14 SIGLEC5

9.79e-0461162GO:0101003
GeneOntologyCellularComponenttertiary granule membrane

SIGLEC14 SIGLEC5

1.40e-0373162GO:0070821
GeneOntologyCellularComponenthistone acetyltransferase complex

JADE2 JADE1

2.30e-0394162GO:0000123
GeneOntologyCellularComponentprotein acetyltransferase complex

JADE2 JADE1

2.81e-03104162GO:0031248
GeneOntologyCellularComponentacetyltransferase complex

JADE2 JADE1

3.08e-03109162GO:1902493
MousePhenoabnormal eosinophil differentiation

SIGLEC14 SIGLEC5

5.58e-064142MP:0002443
DomainEnhancer_polycomb-like_N

JADE2 JADE1

1.92e-058162IPR019542
DomainEPL1

JADE2 JADE1

1.92e-058162PF10513
DomainEPHD

JADE2 JADE1

1.57e-0422162PS51805
DomainIg/MHC_CS

SIGLEC14 SIGLEC5

1.11e-0358162IPR003006
DomainIG_MHC

SIGLEC14 SIGLEC5

1.18e-0360162PS00290
DomainZinc_finger_PHD-type_CS

JADE2 JADE1

1.39e-0365162IPR019786
DomainPHD

JADE2 JADE1

1.84e-0375162PF00628
DomainZnf_PHD-finger

JADE2 JADE1

2.04e-0379162IPR019787
DomainPHD

JADE2 JADE1

2.58e-0389162SM00249
DomainZnf_PHD

JADE2 JADE1

2.70e-0391162IPR001965
DomainZF_PHD_2

JADE2 JADE1

2.93e-0395162PS50016
DomainZF_PHD_1

JADE2 JADE1

2.99e-0396162PS01359
DomainZnf_FYVE_PHD

JADE2 JADE1

6.87e-03147162IPR011011
DomainV-set

SIGLEC14 SIGLEC5

1.06e-02184162PF07686
DomainHomeobox_CS

CUX1 HMX3

1.08e-02186162IPR017970
DomainImmunoglobulin

SIGLEC14 SIGLEC5

1.12e-02190162IPR013151
Domainig

SIGLEC14 SIGLEC5

1.12e-02190162PF00047
DomainIg_V-set

SIGLEC14 SIGLEC5

1.23e-02199162IPR013106
DomainHomeobox

CUX1 HMX3

1.67e-02234162PF00046
DomainIg_sub2

SIGLEC14 SIGLEC5

1.68e-02235162IPR003598
DomainIGc2

SIGLEC14 SIGLEC5

1.68e-02235162SM00408
DomainHOMEOBOX_1

CUX1 HMX3

1.70e-02236162PS00027
DomainHOX

CUX1 HMX3

1.71e-02237162SM00389
DomainHomeobox_dom

CUX1 HMX3

1.74e-02239162IPR001356
DomainHOMEOBOX_2

CUX1 HMX3

1.74e-02239162PS50071
DomainIg-like_fold

PTPRH SIGLEC14 SIGLEC5

2.09e-02706163IPR013783
Domain-

CUX1 HMX3

2.39e-022831621.10.10.60
PathwayREACTOME_HATS_ACETYLATE_HISTONES

JADE2 JADE1

5.62e-0446112MM14935
Pubmed

Siglec-5 and Siglec-14 are polymorphic paired receptors that modulate neutrophil and amnion signaling responses to group B Streptococcus.

SIGLEC14 SIGLEC5

1.98e-07216224799499
Pubmed

Immunomodulatory activity of extracellular Hsp70 mediated via paired receptors Siglec-5 and Siglec-14.

SIGLEC14 SIGLEC5

1.98e-07216226459514
Pubmed

Discovery of Siglec-14, a novel sialic acid receptor undergoing concerted evolution with Siglec-5 in primates.

SIGLEC14 SIGLEC5

5.95e-07316217012248
Pubmed

Siglec-F is induced by granulocyte-macrophage colony-stimulating factor and enhances interleukin-4-induced expression of arginase-1 in mouse macrophages.

SIGLEC14 SIGLEC5

5.95e-07316231520477
Pubmed

Ectopic expression of Cux1 is associated with reduced p27 expression and increased apoptosis during late stage cyst progression upon inactivation of Pkd1 in collecting ducts.

CUX1 PKD1

5.95e-07316221465620
Pubmed

Antiallergic effect of anti-Siglec-F through reduction of eosinophilic inflammation in murine allergic rhinitis.

SIGLEC14 SIGLEC5

5.95e-07316223710953
Pubmed

Anti-Siglec-F antibody reduces allergen-induced eosinophilic inflammation and airway remodeling.

SIGLEC14 SIGLEC5

5.95e-07316219783675
Pubmed

Mast Cell-Specific Expression of Human Siglec-8 in Conditional Knock-in Mice.

SIGLEC14 SIGLEC5

5.95e-07316230577572
Pubmed

Siglec-F-dependent negative regulation of allergen-induced eosinophilia depends critically on the experimental model.

SIGLEC14 SIGLEC5

5.95e-07316224698729
Pubmed

Identification of Jade1, a gene encoding a PHD zinc finger protein, in a gene trap mutagenesis screen for genes involved in anteroposterior axis development.

JADE2 JADE1

5.95e-07316214612400
Pubmed

Cux1 promotes cell proliferation and polycystic kidney disease progression in an ADPKD mouse model.

CUX1 PKD1

5.95e-07316228701314
Pubmed

A novel Siglec-F+ neutrophil subset in the mouse nasal mucosa exhibits an activated phenotype and is increased in an allergic rhinitis model.

SIGLEC14 SIGLEC5

5.95e-07316232247614
Pubmed

Frontline Science: Superior mouse eosinophil depletion in vivo targeting transgenic Siglec-8 instead of endogenous Siglec-F: Mechanisms and pitfalls.

SIGLEC14 SIGLEC5

5.95e-07316232134149
Pubmed

Cloning and characterization of a novel mouse Siglec, mSiglec-F: differential evolution of the mouse and human (CD33) Siglec-3-related gene clusters.

SIGLEC14 SIGLEC5

5.95e-07316211579105
Pubmed

Endogenous airway mucins carry glycans that bind Siglec-F and induce eosinophil apoptosis.

SIGLEC14 SIGLEC5

5.95e-07316225497369
Pubmed

Polycystin-1 regulates the stability and ubiquitination of transcription factor Jade-1.

JADE1 PKD1

5.95e-07316223001567
Pubmed

Siglec-F is a novel intestinal M cell marker.

SIGLEC14 SIGLEC5

5.95e-07316227524237
Pubmed

Distinct endocytic mechanisms of CD22 (Siglec-2) and Siglec-F reflect roles in cell signaling and innate immunity.

SIGLEC14 SIGLEC5

1.19e-06416217562860
Pubmed

Defining the in vivo function of Siglec-F, a CD33-related Siglec expressed on mouse eosinophils.

SIGLEC14 SIGLEC5

1.19e-06416217272508
Pubmed

Siglec-8 on human eosinophils and mast cells, and Siglec-F on murine eosinophils, are functionally related inhibitory receptors.

SIGLEC14 SIGLEC5

1.19e-06416219178537
Pubmed

Novel Genetic Loci Associated with the Plasma Triglyceride Response to an Omega-3 Fatty Acid Supplementation.

JADE1 NXPH1

1.19e-06416227160456
Pubmed

IL-17 mediates protective immunity against nasal infection with Bordetella pertussis by mobilizing neutrophils, especially Siglec-F+ neutrophils.

SIGLEC14 SIGLEC5

1.19e-06416233976385
Pubmed

Plasma Triglyceride Levels May Be Modulated by Gene Expression of IQCJ, NXPH1, PHF17 and MYB in Humans.

JADE1 NXPH1

1.19e-06416228134766
Pubmed

Phosphoproteomics identifies microglial Siglec-F inflammatory response during neurodegeneration.

SIGLEC14 SIGLEC5

1.19e-06416233289969
Pubmed

Induction of Siglec-FhiCD101hi eosinophils in the lungs following murine hookworm Nippostrongylus brasiliensis infection.

SIGLEC14 SIGLEC5

1.19e-06416237251384
Pubmed

Siglec-F-expressing neutrophils are essential for creating a profibrotic microenvironment in renal fibrosis.

SIGLEC14 SIGLEC5

1.98e-06516235482420
Pubmed

Characterization of expression of glycan ligands for Siglec-F in normal mouse lungs.

SIGLEC14 SIGLEC5

1.98e-06516220395633
Pubmed

Chronic OVA allergen challenged Siglec-F deficient mice have increased mucus, remodeling, and epithelial Siglec-F ligands which are up-regulated by IL-4 and IL-13.

SIGLEC14 SIGLEC5

1.98e-06516221040544
Pubmed

Molecular analysis of human Siglec-8 orthologs relevant to mouse eosinophils: identification of mouse orthologs of Siglec-5 (mSiglec-F) and Siglec-10 (mSiglec-G).

SIGLEC14 SIGLEC5

2.97e-06616214559209
Pubmed

Galactose 6-O-sulfotransferases are not required for the generation of Siglec-F ligands in leukocytes or lung tissue.

SIGLEC14 SIGLEC5

2.97e-06616223880769
Pubmed

[Functions and molecular evolution of Siglecs, a family of sialic acid receptor proteins].

SIGLEC14 SIGLEC5

4.16e-06716218453149
Pubmed

Sialyltransferase ST3Gal-III regulates Siglec-F ligand formation and eosinophilic lung inflammation in mice.

SIGLEC14 SIGLEC5

4.16e-06716223677475
Pubmed

Mechanisms of Siglec-F-induced eosinophil apoptosis: a role for caspases but not for SHP-1, Src kinases, NADPH oxidase or reactive oxygen.

SIGLEC14 SIGLEC5

4.16e-06716223840825
Pubmed

The murine inhibitory receptor mSiglec-E is expressed broadly on cells of the innate immune system whereas mSiglec-F is restricted to eosinophils.

SIGLEC14 SIGLEC5

4.16e-06716215048729
Pubmed

Polycystic kidneys caused by sustained expression of Cux1 isoform p75.

CUX1 PKD1

7.13e-06916218356167
Pubmed

Selective Response to Bacterial Infection by Regulating Siglec-E Expression.

SIGLEC14 SIGLEC5

1.09e-051116232889432
Pubmed

CD24-Siglec axis is an innate immune checkpoint against metaflammation and metabolic disorder.

SIGLEC14 SIGLEC5

1.54e-051316235921817
Pubmed

ASPM regulates symmetric stem cell division by tuning Cyclin E ubiquitination.

CUX1 FAT2

2.69e-051716226581405
Pubmed

Small intestinal resident eosinophils maintain gut homeostasis following microbial colonization.

SIGLEC14 SIGLEC5

2.69e-051716235709757
Pubmed

KAT7/HBO1/MYST2 Regulates CENP-A Chromatin Assembly by Antagonizing Suv39h1-Mediated Centromere Inactivation.

JADE2 JADE1

4.15e-052116227270040
Pubmed

A mouse knockout library for secreted and transmembrane proteins.

SIGLEC14 IL17F SIGLEC5 INTS1

4.85e-0546016420562862
Pubmed

Large-scale sequencing of the CD33-related Siglec gene cluster in five mammalian species reveals rapid evolution by multiple mechanisms.

SIGLEC14 SIGLEC5

5.44e-052416215331780
Pubmed

A suite of new Dre recombinase drivers markedly expands the ability to perform intersectional genetic targeting.

SIGLEC14 SIGLEC5

8.00e-052916233567267
Pubmed

Histone deacetylase 3 controls lung alveolar macrophage development and homeostasis.

SIGLEC14 SIGLEC5

1.31e-043716232732898
Pubmed

ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation.

JADE2 JADE1

1.69e-044216216387653
Pubmed

E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.

RPE65 CA5A INTS1 PKD1

2.96e-0473616429676528
Pubmed

Gene expression analysis of the late embryonic mouse cerebral cortex using DNA microarray: identification of several region- and layer-specific genes.

CUX1 JADE1

4.57e-046916215142957
InteractionJADE1 interactions

JADE2 JADE1 PKD1

2.90e-0577163int:JADE1
Cytoband19q13.4

PTPRH SIGLEC14

3.45e-047916219q13.4
CytobandEnsembl 112 genes in cytogenetic band chr19q13

PTPRH SIGLEC14 SIGLEC5 SSC5D

6.41e-041192164chr19q13
GeneFamilyCD molecules|C2-set domain containing|Sialic acid binding Ig like lectins

SIGLEC14 SIGLEC5

1.79e-0428132745
GeneFamilyPHD finger proteins

JADE2 JADE1

1.84e-039013288
GeneFamilyAdenosine receptors|V-set domain containing

SIGLEC14 SIGLEC5

5.90e-03163132590
Diseasedolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 measurement

SIGLEC14 SIGLEC5

1.24e-0510162EFO_0801544
Diseasesialic acid-binding Ig-like lectin 14 measurement

SIGLEC14 SIGLEC5

1.81e-0512162EFO_0008284
Diseaseplatelet component distribution width

PTPRH SIGLEC14 JADE2 SIGLEC5 CUX1

3.74e-05755165EFO_0007984
Diseasemonocyte count

PTPRH SIGLEC14 JADE2 SIGLEC5 PKD1

5.14e-041320165EFO_0005091
Diseaseresponse to antidepressant

CUX1 HMX3

4.02e-03176162GO_0036276
Diseaseneutrophil percentage of leukocytes

SIGLEC5 CA5A ISM2

4.03e-03610163EFO_0007990
Diseaseperiodontitis

SIGLEC5 HMX3

6.36e-03223162EFO_0000649
Diseaseheart rate

CUX1 CA5A

6.47e-03225162EFO_0004326
Diseaseresponse to bronchodilator, FEV/FEC ratio

PTPRH FAT2 NXPH1

7.58e-03766163EFO_0004713, GO_0097366
DiseaseJT interval

JADE2 CUX1

7.81e-03248162EFO_0007885
DiseaseDrugs used in diabetes use measurement

PTPRH JADE2

8.24e-03255162EFO_0009924

Protein segments in the cluster

PeptideGeneStartEntry
SEYWKEWPSAESPYS

CUX1

876

P39880
PETYYKWDNWPPESD

INTS1

621

Q8N201
ERSPAWWYPYTLTPA

HMX3

111

A6NHT5
PDDYYILADPWRQEW

JADE2

71

Q9NQC1
SVSYDYEPQKEWSPW

ISM2

321

Q6H9L7
WPPTYSRNERWEYPH

FAT2

4181

Q9NYQ8
PWNYTVTWDPNRYPS

IL17F

81

Q96PD4
DPSTLLPTCWDYWTY

CA5A

216

P35218
VACAWPPFPYRYTWD

PKD1

1401

P98161
ETWVWQEPDSYPSEP

RPE65

456

Q16518
YDTPEPYSEQDLWDW

NXPH1

76

P58417
CSFSYPWRSWYSSPP

SIGLEC5

41

O15389
PDEYYVLADPWRQEW

JADE1

66

Q6IE81
CTGYTDYDDYPPWTW

SSC5D

871

A1L4H1
DYDDYPPWTWDPTSR

SSC5D

876

A1L4H1
WEVPDGPYPQDYTYW

PTPRH

406

Q9HD43
CSFSYPWRSWYSSPP

SIGLEC14

41

Q08ET2