Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	calcium-dependent protein binding	RBM22 TSG101 SEC31A PDCD6IP MASP2	1.67e-06	98	41	5	GO:0048306
GeneOntologyMolecularFunction	disaccharide binding	LGALS9C LGALS9B	8.58e-05	7	41	2	GO:0048030
GeneOntologyMolecularFunction	galactoside binding	LGALS9C LGALS9B	1.47e-04	9	41	2	GO:0016936
GeneOntologyMolecularFunction	oligosaccharide binding	LGALS9C LGALS9B	7.63e-04	20	41	2	GO:0070492
GeneOntologyMolecularFunction	WW domain binding	LITAF SHISA5	1.20e-03	25	41	2	GO:0050699
GeneOntologyBiologicalProcess	negative regulation of natural killer cell degranulation	LGALS9C LGALS9B	2.09e-05	4	39	2	GO:0043322
GeneOntologyBiologicalProcess	regulation of extracellular exosome assembly	TSG101 PDCD6IP	5.20e-05	6	39	2	GO:1903551
GeneOntologyBiologicalProcess	extracellular exosome assembly	TSG101 PDCD6IP	7.27e-05	7	39	2	GO:0071971
GeneOntologyBiologicalProcess	regulation of natural killer cell degranulation	LGALS9C LGALS9B	9.68e-05	8	39	2	GO:0043321
GeneOntologyBiologicalProcess	positive regulation of interleukin-10 production	LGALS9C IRF4 LGALS9B	1.02e-04	48	39	3	GO:0032733
GeneOntologyBiologicalProcess	regulation of vesicle-mediated transport	LGALS9C MAGI2 NUMB RNF216 TSG101 PDCD6IP LGALS9B	2.24e-04	667	39	7	GO:0060627
GeneOntologyBiologicalProcess	T-helper 17 type immune response	LGALS9C IRF4 LGALS9B	2.40e-04	64	39	3	GO:0072538
GeneOntologyBiologicalProcess	negative regulation of natural killer cell activation	LGALS9C LGALS9B	3.60e-04	15	39	2	GO:0032815
GeneOntologyBiologicalProcess	negative regulation of CD4-positive, alpha-beta T cell proliferation	LGALS9C LGALS9B	3.60e-04	15	39	2	GO:2000562
GeneOntologyBiologicalProcess	regulation of interleukin-10 production	LGALS9C IRF4 LGALS9B	3.69e-04	74	39	3	GO:0032653
GeneOntologyBiologicalProcess	positive regulation of exosomal secretion	TSG101 PDCD6IP	4.11e-04	16	39	2	GO:1903543
GeneOntologyBiologicalProcess	interleukin-10 production	LGALS9C IRF4 LGALS9B	4.15e-04	77	39	3	GO:0032613
GeneOntologyBiologicalProcess	negative regulation of leukocyte degranulation	LGALS9C LGALS9B	4.65e-04	17	39	2	GO:0043301
GeneOntologyBiologicalProcess	receptor clustering	LGALS9C MAGI2 LGALS9B	5.17e-04	83	39	3	GO:0043113
GeneOntologyBiologicalProcess	natural killer cell degranulation	LGALS9C LGALS9B	5.23e-04	18	39	2	GO:0043320
GeneOntologyBiologicalProcess	negative regulation of alpha-beta T cell proliferation	LGALS9C LGALS9B	5.84e-04	19	39	2	GO:0046642
GeneOntologyBiologicalProcess	positive regulation of defense response to bacterium	LGALS9C LGALS9B	5.84e-04	19	39	2	GO:1900426
GeneOntologyBiologicalProcess	toll-like receptor signaling pathway	IRF4 TNIP1 GPS2	6.14e-04	88	39	3	GO:0002224
GeneOntologyBiologicalProcess	regulation of exosomal secretion	TSG101 PDCD6IP	6.48e-04	20	39	2	GO:1903541
GeneOntologyBiologicalProcess	regulation of T cell chemotaxis	LGALS9C LGALS9B	6.48e-04	20	39	2	GO:0010819
GeneOntologyBiologicalProcess	regulation of natural killer cell differentiation	LGALS9C LGALS9B	7.15e-04	21	39	2	GO:0032823
GeneOntologyBiologicalProcess	regulation of receptor internalization	MAGI2 NUMB RNF216	7.67e-04	95	39	3	GO:0002090
GeneOntologyBiologicalProcess	viral budding via host ESCRT complex	TSG101 PDCD6IP	8.60e-04	23	39	2	GO:0039702
GeneOntologyBiologicalProcess	regulation of CD4-positive, alpha-beta T cell activation	LGALS9C IRF4 LGALS9B	8.90e-04	100	39	3	GO:2000514
GeneOntologyBiologicalProcess	exosomal secretion	TSG101 PDCD6IP	9.37e-04	24	39	2	GO:1990182
GeneOntologyBiologicalProcess	regulation of exocytosis	LGALS9C TSG101 PDCD6IP LGALS9B	9.57e-04	233	39	4	GO:0017157
GeneOntologyBiologicalProcess	extracellular exosome biogenesis	TSG101 PDCD6IP	1.02e-03	25	39	2	GO:0097734
GeneOntologyBiologicalProcess	negative regulation of toll-like receptor signaling pathway	IRF4 GPS2	1.02e-03	25	39	2	GO:0034122
GeneOntologyBiologicalProcess	viral budding	TSG101 PDCD6IP	1.10e-03	26	39	2	GO:0046755
GeneOntologyBiologicalProcess	regulation of defense response to bacterium	LGALS9C LGALS9B	1.10e-03	26	39	2	GO:1900424
GeneOntologyBiologicalProcess	positive regulation of innate immune response	LGALS9C IRF4 TNIP1 LGALS9B GPS2	1.11e-03	420	39	5	GO:0045089
GeneOntologyBiologicalProcess	SMAD protein signal transduction	LGALS9C MAGI2 LGALS9B	1.17e-03	110	39	3	GO:0060395
GeneOntologyBiologicalProcess	extracellular vesicle biogenesis	TSG101 PDCD6IP	1.19e-03	27	39	2	GO:0140112
GeneOntologyBiologicalProcess	regulation of response to biotic stimulus	LGALS9C RNF216 IRF4 TNIP1 LGALS9B GPS2	1.22e-03	643	39	6	GO:0002831
GeneOntologyBiologicalProcess	regulation of CD4-positive, alpha-beta T cell proliferation	LGALS9C LGALS9B	1.28e-03	28	39	2	GO:2000561
GeneOntologyCellularComponent	Flemming body	ZFYVE19 TSG101 PDCD6IP	4.78e-05	36	41	3	GO:0090543
GeneOntologyCellularComponent	endoplasmic reticulum exit site	SEC31A PDCD6IP SEC23IP	7.62e-05	42	41	3	GO:0070971
MousePheno	abnormal lymph node germinal center morphology	LGALS9C IRF4 LGALS9B	3.16e-05	23	38	3	MP:0008522
MousePheno	abnormal lymph node secondary follicle morphology	LGALS9C IRF4 LGALS9B	4.09e-05	25	38	3	MP:0002346
MousePheno	lymph node hyperplasia	LGALS9C TNIP1 LGALS9B	9.56e-05	33	38	3	MP:0008102
MousePheno	abnormal CD4-positive helper T cell morphology	LGALS9C IRF4 TNIP1 LGALS9B	1.51e-04	100	38	4	MP:0010183
MousePheno	abnormal spleen germinal center morphology	LGALS9C IRF4 TNIP1 LGALS9B	1.96e-04	107	38	4	MP:0002359
MousePheno	abnormal spleen secondary B follicle morphology	LGALS9C IRF4 TNIP1 LGALS9B	2.10e-04	109	38	4	MP:0008472
MousePheno	abnormal lymph node B cell domain morphology	LGALS9C IRF4 LGALS9B	2.27e-04	44	38	3	MP:0002344
Domain	Shisa	SHISA4 SHISA5	1.59e-04	9	40	2	PF13908
Domain	Shisa	SHISA4 SHISA5	1.59e-04	9	40	2	IPR026910
Domain	Znf_CCCH	ZC3H12B RBM22 MBNL3	2.59e-04	58	40	3	IPR000571
Domain	ZF_C3H1	ZC3H12B RBM22 MBNL3	2.59e-04	58	40	3	PS50103
Domain	Gal-bind_lectin	LGALS9C LGALS9B	4.61e-04	15	40	2	SM00908
Domain	GALECTIN	LGALS9C LGALS9B	4.61e-04	15	40	2	PS51304
Domain	Galectin_CRD	LGALS9C LGALS9B	4.61e-04	15	40	2	IPR001079
Domain	Gal-bind_lectin	LGALS9C LGALS9B	4.61e-04	15	40	2	PF00337
Domain	GLECT	LGALS9C LGALS9B	4.61e-04	15	40	2	SM00276
Domain	Nucleotide-bd_a/b_plait	SRRT RBM22 EWSR1 RBM20	2.20e-03	258	40	4	IPR012677
Domain	ZnF_C3H1	RBM22 MBNL3	4.74e-03	48	40	2	SM00356
Domain	zf-CCCH	RBM22 MBNL3	4.94e-03	49	40	2	PF00642
Domain	SAM_1	CASKIN2 SEC23IP	9.32e-03	68	40	2	PF00536
Domain	RRM	RBM22 EWSR1 RBM20	1.11e-02	217	40	3	SM00360
Domain	RRM_dom	RBM22 EWSR1 RBM20	1.26e-02	227	40	3	IPR000504
Domain	RRM	RBM22 EWSR1 RBM20	1.30e-02	230	40	3	PS50102
Domain	SAM	CASKIN2 SEC23IP	1.52e-02	88	40	2	SM00454
Pubmed	Regulation of the CUL3 Ubiquitin Ligase by a Calcium-Dependent Co-adaptor.	TNIP1 TSG101 SEC31A PDCD6IP SEC23IP	3.60e-09	50	41	5	27716508
Pubmed	Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.	NUMB TSG101 CHD7 PDCD6IP EIF4G3 SHISA4 LITAF YLPM1	3.42e-08	430	41	8	35044719
Pubmed	Molecular basis for defect in Alix-binding by alternatively spliced isoform of ALG-2 (ALG-2DeltaGF122) and structural roles of F122 in target recognition.	TSG101 SEC31A PDCD6IP	5.30e-08	7	41	3	20691033
Pubmed	Proline-rich sequence recognition: II. Proteomics analysis of Tsg101 ubiquitin-E2-like variant (UEV) interactions.	EWSR1 TSG101 PDCD6IP SEC23IP	5.83e-08	32	41	4	19542561
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	BTG3 MAGI2 RNF216 RBM22 EWSR1 TSG101 SEC31A EIF4G3 CUEDC1 YLPM1 SEC23IP	1.91e-07	1285	41	11	35914814
Pubmed	Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations.	ZFYVE19 TNIP1 EWSR1 PSMF1 TSG101 PDCD6IP LGALS9B ZNF366 C1orf94 LITAF GPS2	7.61e-07	1477	41	11	31515488
Pubmed	Peptide inhibitors of HIV-1 egress.	TSG101 PDCD6IP	1.36e-06	2	41	2	19099395
Pubmed	[HIV-1 infection affects the expression of host cell factor TSG101 and Alix].	TSG101 PDCD6IP	1.36e-06	2	41	2	21528537
Pubmed	Transcriptional map of the Treacher Collins candidate gene region.	TNIP1 RBM22	1.36e-06	2	41	2	8681136
Pubmed	Three-dimensional analysis of budding sites and released virus suggests a revised model for HIV-1 morphogenesis.	TSG101 PDCD6IP	1.36e-06	2	41	2	19064259
Pubmed	Tsg101 and Alix interact with murine leukemia virus Gag and cooperate with Nedd4 ubiquitin ligases during budding.	TSG101 PDCD6IP	1.36e-06	2	41	2	15908698
Pubmed	Solution structure of the human immunodeficiency virus type 1 p6 protein.	TSG101 PDCD6IP	1.36e-06	2	41	2	16234236
Pubmed	HIV-1 Gag release from yeast reveals ESCRT interaction with the Gag N-terminal protein region.	TSG101 PDCD6IP	1.36e-06	2	41	2	32994219
Pubmed	Variability in the P6gag domains of HIV-1 involved in viral budding.	TSG101 PDCD6IP	1.36e-06	2	41	2	16470130
Pubmed	Herpes simplex virus type 1 production requires a functional ESCRT-III complex but is independent of TSG101 and ALIX expression.	TSG101 PDCD6IP	1.36e-06	2	41	2	19692479
Pubmed	The nucleocapsid region of HIV-1 Gag cooperates with the PTAP and LYPXnL late domains to recruit the cellular machinery necessary for viral budding.	TSG101 PDCD6IP	1.36e-06	2	41	2	19282983
Pubmed	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.	SRRT RBM22 EWSR1 EIF4G3 MBNL3 BAG4 YLPM1 ALG13	3.94e-06	807	41	8	22681889
Pubmed	Crystal structure of the galectin-9 N-terminal carbohydrate recognition domain from Mus musculus reveals the basic mechanism of carbohydrate recognition.	LGALS9C LGALS9B	4.06e-06	3	41	2	16990264
Pubmed	Galectin-9 Is Critical for Mucosal Adaptive Immunity through the T Helper 17-IgA Axis.	LGALS9C LGALS9B	4.06e-06	3	41	2	29458010
Pubmed	Structural analysis of the human galectin-9 N-terminal carbohydrate recognition domain reveals unexpected properties that differ from the mouse orthologue.	LGALS9C LGALS9B	4.06e-06	3	41	2	18005988
Pubmed	Galectin-9 ameliorates clinical severity of MRL/lpr lupus-prone mice by inducing plasma cell apoptosis independently of Tim-3.	LGALS9C LGALS9B	4.06e-06	3	41	2	23585851
Pubmed	Galectin-9 ameliorates anti-GBM glomerulonephritis by inhibiting Th1 and Th17 immune responses in mice.	LGALS9C LGALS9B	4.06e-06	3	41	2	24477688
Pubmed	Structural and biochemical studies of ALIX/AIP1 and its role in retrovirus budding.	TSG101 PDCD6IP	4.06e-06	3	41	2	17350572
Pubmed	Galectin-9 is a high affinity IgE-binding lectin with anti-allergic effect by blocking IgE-antigen complex formation.	LGALS9C LGALS9B	4.06e-06	3	41	2	19776007
Pubmed	A unique role for galectin-9 in angiogenesis and inflammatory arthritis.	LGALS9C LGALS9B	4.06e-06	3	41	2	29433546
Pubmed	Cooperative Interactions of Oligosaccharide and Peptide Moieties of a Glycopeptide Derived from IgE with Galectin-9.	LGALS9C LGALS9B	4.06e-06	3	41	2	26582205
Pubmed	Oncogenic miR-93-5p/Gal-9 axis drives CD8 (+) T-cell inactivation and is a therapeutic target for hepatocellular carcinoma immunotherapy.	LGALS9C LGALS9B	4.06e-06	3	41	2	37105392
Pubmed	Developmental regulation, expression, and apoptotic potential of galectin-9, a beta-galactoside binding lectin.	LGALS9C LGALS9B	4.06e-06	3	41	2	9153289
Pubmed	Galectin-9 regulates follicular helper T cells to inhibit humoral autoimmunity-induced pulmonary fibrosis.	LGALS9C LGALS9B	4.06e-06	3	41	2	33316546
Pubmed	Galectin-9 expands unique macrophages exhibiting plasmacytoid dendritic cell-like phenotypes that activate NK cells in tumor-bearing mice.	LGALS9C LGALS9B	4.06e-06	3	41	2	18974023
Pubmed	Identification and characterization of galectin-9, a novel beta-galactoside-binding mammalian lectin.	LGALS9C LGALS9B	4.06e-06	3	41	2	9038233
Pubmed	HIV Gag polyprotein: processing and early viral particle assembly.	TSG101 PDCD6IP	4.06e-06	3	41	2	23266279
Pubmed	Midbody targeting of the ESCRT machinery by a noncanonical coiled coil in CEP55.	TSG101 PDCD6IP	4.06e-06	3	41	2	18948538
Pubmed	Cell surface galectin-9 expressing Th cells regulate Th17 and Foxp3+ Treg development by galectin-9 secretion.	LGALS9C LGALS9B	4.06e-06	3	41	2	23144904
Pubmed	Impaired Gal-9 Dysregulates the PBMC-Induced Th1/Th2 Imbalance in Abortion-Prone Matings.	LGALS9C LGALS9B	4.06e-06	3	41	2	29651447
Pubmed	Galectin-9/Tim-3 pathway mediates dopaminergic neurodegeneration in MPTP-induced mouse model of Parkinson's disease.	LGALS9C LGALS9B	4.06e-06	3	41	2	36479526
Pubmed	Protective effect of Galectin-9 in murine model of lung emphysema: Involvement of neutrophil migration and MMP-9 production.	LGALS9C LGALS9B	4.06e-06	3	41	2	28704475
Pubmed	The N- and C-terminal carbohydrate recognition domains of galectin-9 contribute differently to its multiple functions in innate immunity and adaptive immunity.	LGALS9C LGALS9B	4.06e-06	3	41	2	21146220
Pubmed	Profiling Lgals9 splice variant expression at the fetal-maternal interface: implications in normal and pathological human pregnancy.	LGALS9C LGALS9B	4.06e-06	3	41	2	23242525
Pubmed	Galectin-9 in allergic airway inflammation and hyper-responsiveness in mice.	LGALS9C LGALS9B	4.06e-06	3	41	2	19851072
Pubmed	The Role of Galectin-9 as Mediator of Atopic Dermatitis: Effect on Keratinocytes.	LGALS9C LGALS9B	4.06e-06	3	41	2	33923930
Pubmed	Alarmin function of galectin-9 in murine respiratory tularemia.	LGALS9C LGALS9B	4.06e-06	3	41	2	25898318
Pubmed	Amelioration of bleomycin-induced pulmonary fibrosis via TGF-β-induced Smad and non-Smad signaling pathways in galectin-9-deficient mice and fibroblast cells.	LGALS9C LGALS9B	4.06e-06	3	41	2	31937306
Pubmed	Intestinal epithelial cells express galectin-9 in patients with food allergy that plays a critical role in sustaining allergic status in mouse intestine.	LGALS9C LGALS9B	4.06e-06	3	41	2	21426359
Pubmed	Intracellular Galectin-9 Enhances Proximal TCR Signaling and Potentiates Autoimmune Diseases.	LGALS9C LGALS9B	4.06e-06	3	41	2	31969388
Pubmed	Galectin-9 protein is up-regulated in astrocytes by tumor necrosis factor and promotes encephalitogenic T-cell apoptosis.	LGALS9C LGALS9B	4.06e-06	3	41	2	23836896
Pubmed	Galectin-9 suppresses the generation of Th17, promotes the induction of regulatory T cells, and regulates experimental autoimmune arthritis.	LGALS9C LGALS9B	4.06e-06	3	41	2	18282810
Pubmed	Parallels between cytokinesis and retroviral budding: a role for the ESCRT machinery.	TSG101 PDCD6IP	4.06e-06	3	41	2	17556548
Pubmed	Obesity-induced galectin-9 is a therapeutic target in B-cell acute lymphoblastic leukemia.	LGALS9C LGALS9B	4.06e-06	3	41	2	35241678
Pubmed	Sequence and mapping of galectin-5, a beta-galactoside-binding lectin, found in rat erythrocytes.	LGALS9C LGALS9B	4.06e-06	3	41	2	7890611
Pubmed	Proline-rich domain of human ALIX contains multiple TSG101-UEV interaction sites and forms phosphorylation-mediated reversible amyloids.	TSG101 PDCD6IP	4.06e-06	3	41	2	32917811
Pubmed	Galectin-9 suppresses Th17 cell development in an IL-2-dependent but Tim-3-independent manner.	LGALS9C LGALS9B	4.06e-06	3	41	2	22341088
Pubmed	Regulation of M1‑type and M2‑type macrophage polarization in RAW264.7 cells by Galectin‑9.	LGALS9C LGALS9B	4.06e-06	3	41	2	28990062
Pubmed	Galectin-9 Is a Novel Regulator of Epithelial Restitution.	LGALS9C LGALS9B	4.06e-06	3	41	2	32380082
Pubmed	Galectin-9 is a suppressor of T and B cells and predicts the immune modulatory potential of mesenchymal stromal cell preparations.	LGALS9C LGALS9B	4.06e-06	3	41	2	24083426
Pubmed	Galectin-9-mediated protection from allo-specific T cells as a mechanism of immune privilege of corneal allografts.	LGALS9C LGALS9B	4.06e-06	3	41	2	23667648
Pubmed	Galectin-9 in synergy with NF-κB inhibition restores immune regulatory capability in dendritic cells of subjects with food allergy.	LGALS9C LGALS9B	4.06e-06	3	41	2	37279535
Pubmed	Galectin-9 suppresses tumor metastasis by blocking adhesion to endothelium and extracellular matrices.	LGALS9C LGALS9B	4.06e-06	3	41	2	18579572
Pubmed	The protective function of galectin-9 in liver ischemia and reperfusion injury in mice.	LGALS9C LGALS9B	4.06e-06	3	41	2	25931247
Pubmed	ALG-2 directly binds Sec31A and localizes at endoplasmic reticulum exit sites in a Ca2+-dependent manner.	SEC31A PDCD6IP	4.06e-06	3	41	2	17196169
Pubmed	Possible regulatory role of galectin-9 on Ascaris suum-induced eosinophilic lung inflammation in mice.	LGALS9C LGALS9B	4.06e-06	3	41	2	22627368
Pubmed	Regulatory T Cell-Mediated Suppression of Inflammation Induced by DR3 Signaling Is Dependent on Galectin-9.	LGALS9C LGALS9B	4.06e-06	3	41	2	28877989
Pubmed	Galectin-9 is required for endometrial regenerative cells to induce long-term cardiac allograft survival in mice.	LGALS9C LGALS9B	4.06e-06	3	41	2	33153471
Pubmed	Galectin-9 ameliorates immune complex-induced arthritis by regulating Fc gamma R expression on macrophages.	LGALS9C LGALS9B	4.06e-06	3	41	2	19800850
Pubmed	T cell immunoglobulin and mucin protein-3 (Tim-3)/Galectin-9 interaction regulates influenza A virus-specific humoral and CD8 T-cell responses.	LGALS9C LGALS9B	4.06e-06	3	41	2	22052881
Pubmed	SIMPLE interacts with NEDD4 and TSG101: evidence for a role in lysosomal sorting and implications for Charcot-Marie-Tooth disease.	TSG101 LITAF	4.06e-06	3	41	2	16118794
Pubmed	Galectin-9 protects mice from the Shwartzman reaction by attracting prostaglandin E2-producing polymorphonuclear leukocytes.	LGALS9C LGALS9B	4.06e-06	3	41	2	17560833
Pubmed	The effect of Toxoplasma gondii infection on galectin-9 expression in decidual macrophages contributing to dysfunction of decidual NK cells during pregnancy.	LGALS9C LGALS9B	4.06e-06	3	41	2	38987795
Pubmed	Galectin-9 supports primary T cell transendothelial migration in a glycan and integrin dependent manner.	LGALS9C LGALS9B	4.06e-06	3	41	2	35643073
Pubmed	Galectin-9 functionally impairs natural killer cells in humans and mice.	LGALS9C LGALS9B	4.06e-06	3	41	2	23408620
Pubmed	Structural analysis of the complex between penta-EF-hand ALG-2 protein and Sec31A peptide reveals a novel target recognition mechanism of ALG-2.	SEC31A PDCD6IP	4.06e-06	3	41	2	25667979
Pubmed	Beyond Tsg101: the role of Alix in 'ESCRTing' HIV-1.	TSG101 PDCD6IP	4.06e-06	3	41	2	17982468
Pubmed	Functional proteomics mapping of a human signaling pathway.	RNF216 TNIP1 EWSR1 PDCD6IP LITAF CUEDC1 YLPM1	5.38e-06	591	41	7	15231748
Pubmed	TEX14 interacts with CEP55 to block cell abscission.	TSG101 PDCD6IP	8.12e-06	4	41	2	20176808
Pubmed	Galectin-9/TIM-3 interaction regulates virus-specific primary and memory CD8 T cell response.	LGALS9C LGALS9B	8.12e-06	4	41	2	20463811
Pubmed	SARS-Cov-2 spike induces intestinal barrier dysfunction through the interaction between CEACAM5 and Galectin-9.	LGALS9C LGALS9B	8.12e-06	4	41	2	38686388
Pubmed	Contrasting acute graft-versus-host disease effects of Tim-3/galectin-9 pathway blockade dependent upon the presence of donor regulatory T cells.	LGALS9C LGALS9B	8.12e-06	4	41	2	22677125
Pubmed	Lumenal Galectin-9-Lamp2 interaction regulates lysosome and autophagy to prevent pathogenesis in the intestine and pancreas.	LGALS9C LGALS9B	8.12e-06	4	41	2	32855403
Pubmed	Galectin-3 mediates oligomerization of secreted hensin using its carbohydrate-recognition domain.	LGALS9C LGALS9B	8.12e-06	4	41	2	23657851
Pubmed	Role of Tim-3/galectin-9 inhibitory interaction in viral-induced immunopathology: shifting the balance toward regulators.	LGALS9C LGALS9B	8.12e-06	4	41	2	19234217
Pubmed	[Expression and significance of galectin-3 and galectin-9 in mice nasal mucosa with allergic rhinitis].	LGALS9C LGALS9B	8.12e-06	4	41	2	18826117
Pubmed	The Tim-3/galectin-9 pathway involves in the homeostasis of hepatic Tregs in a mouse model of concanavalin A-induced hepatitis.	LGALS9C LGALS9B	8.12e-06	4	41	2	24333756
Pubmed	The expression of Galectin-9 correlates with mTOR and AMPK in murine colony-forming erythroid progenitors.	LGALS9C LGALS9B	8.12e-06	4	41	2	38853593
Pubmed	Penta-EF-hand protein ALG-2 functions as a Ca2+-dependent adaptor that bridges Alix and TSG101.	TSG101 PDCD6IP	8.12e-06	4	41	2	19520058
Pubmed	Collection, storage, preservation, and normalization of human urinary exosomes for biomarker discovery.	TSG101 PDCD6IP	8.12e-06	4	41	2	16501490
Pubmed	Tim-3/Galectin-9 signaling pathway is involved in the cytokine changes in mice with alveolar echinococcosis.	LGALS9C LGALS9B	8.12e-06	4	41	2	35715604
Pubmed	Galectin-9 controls the therapeutic activity of 4-1BB-targeting antibodies.	LGALS9C LGALS9B	8.12e-06	4	41	2	24958847
Pubmed	Galectin-9 increases Tim-3+ dendritic cells and CD8+ T cells and enhances antitumor immunity via galectin-9-Tim-3 interactions.	LGALS9C LGALS9B	8.12e-06	4	41	2	19017954
Pubmed	Galectin-9 binds IgM-BCR to regulate B cell signaling.	LGALS9C LGALS9B	8.12e-06	4	41	2	30120235
Pubmed	Galectin-9 Targets NLRP3 for Autophagic Degradation to Limit Inflammation.	LGALS9C LGALS9B	8.12e-06	4	41	2	33963043
Pubmed	Galectin-9: A novel promoter of atherosclerosis progression.	LGALS9C LGALS9B	8.12e-06	4	41	2	36459823
Pubmed	[Expression of Galectin-9 and Tim-3 in lungs of mice with asthma].	LGALS9C LGALS9B	8.12e-06	4	41	2	21575348
Pubmed	The Race against Protease Activation Defines the Role of ESCRTs in HIV Budding.	TSG101 PDCD6IP	8.12e-06	4	41	2	27280284
Pubmed	Activation of Tim-3-Galectin-9 pathway improves survival of fully allogeneic skin grafts.	LGALS9C LGALS9B	8.12e-06	4	41	2	18346632
Pubmed	Isolation and characterization of a novel eosinophil-specific galectin released into the lungs in response to allergen challenge.	LGALS9C LGALS9B	8.12e-06	4	41	2	11839756
Pubmed	Newly characterized decidual Tim-3+ Treg cells are abundant during early pregnancy and driven by IL-27 coordinately with Gal-9 from trophoblasts.	LGALS9C LGALS9B	8.12e-06	4	41	2	33107565
Pubmed	Monitoring the Rab27 associated exosome pathway using nanoparticle tracking analysis.	TSG101 PDCD6IP	8.12e-06	4	41	2	23092844
Pubmed	Attenuation of Th1 response through galectin-9 and T-cell Ig mucin 3 interaction inhibits autoimmune diabetes in NOD mice.	LGALS9C LGALS9B	8.12e-06	4	41	2	19670381
Pubmed	Galectin-9 inhibits TLR7-mediated autoimmunity in murine lupus models.	LGALS9C LGALS9B	8.12e-06	4	41	2	29611821
Pubmed	Lipopolysaccharide mediates time-dependent macrophage M1/M2 polarization through the Tim-3/Galectin-9 signalling pathway.	LGALS9C LGALS9B	8.12e-06	4	41	2	30763585
Interaction	TSG101 interactions	TNIP1 EWSR1 TSG101 CHD7 PDCD6IP LITAF BAG4 YLPM1 SEC23IP	8.01e-09	303	41	9	int:TSG101
Interaction	RBPMS interactions	LGALS9C RBM22 EWSR1 PSMF1 TSG101 C1orf94 BAG4 GPS2 ALG13	2.17e-08	340	41	9	int:RBPMS
Interaction	DMRTB1 interactions	RBM22 EWSR1 TSG101 C1orf94 BAG4 ALG13	3.45e-08	94	41	6	int:DMRTB1
Interaction	PDCD6 interactions	TNIP1 TSG101 SEC31A PDCD6IP SHISA4 BAG4 SEC23IP	1.65e-07	204	41	7	int:PDCD6
Interaction	SNRPB interactions	MAGI2 SRRT PARD3B TNIP1 RBM22 EWSR1 BAG4 YLPM1	8.06e-06	517	41	8	int:SNRPB
Interaction	VPS37C interactions	TSG101 PDCD6IP C1orf94 BAG4 GPS2	9.55e-06	141	41	5	int:VPS37C
Interaction	RBFOX2 interactions	RBM22 PSMF1 EIF4G3 C1orf94 BAG4 ALG13	2.21e-05	284	41	6	int:RBFOX2
Interaction	RBFOX1 interactions	TNIP1 PSMF1 C1orf94 ALG13	3.62e-05	92	41	4	int:RBFOX1
Interaction	QKI interactions	EWSR1 PSMF1 TSG101 BAG4 ALG13	4.02e-05	190	41	5	int:QKI
Interaction	BMI1 interactions	SRRT RBM22 EWSR1 SEC31A EIF4G3 CASKIN2 YLPM1 SEC23IP	4.61e-05	659	41	8	int:BMI1
Interaction	DAB1 interactions	LGALS9C LGALS9B C1orf94 MBNL3	6.54e-05	107	41	4	int:DAB1
Interaction	PEF1 interactions	EWSR1 SEC31A PDCD6IP BAG4	6.78e-05	108	41	4	int:PEF1
Interaction	BAG4 interactions	RBM22 TSG101 BAG4 GPS2 ALG13	8.78e-05	224	41	5	int:BAG4
Interaction	HNRNPA1 interactions	SRRT PARD3B TNIP1 RBM22 EWSR1 TSG101 SEC31A RBM20 YLPM1	9.52e-05	945	41	9	int:HNRNPA1
Interaction	ALG2 interactions	TSG101 SEC31A SHISA5	9.77e-05	44	41	3	int:ALG2
Interaction	TLE3 interactions	SRRT RNF216 RBM22 RBM20 GPS2 ALG13	1.05e-04	376	41	6	int:TLE3
Interaction	SNRPF interactions	SRRT PARD3B RBM22 EWSR1 SEC31A YLPM1	1.19e-04	385	41	6	int:SNRPF
Interaction	CEP55 interactions	RBM22 EWSR1 TSG101 PDCD6IP BAG4	1.64e-04	256	41	5	int:CEP55
Interaction	GATA4 interactions	SRRT EWSR1 CHD7 SEC31A GPS2 YLPM1	1.70e-04	411	41	6	int:GATA4
Interaction	UBQLN2 interactions	ZFYVE19 EWSR1 PSMF1 TSG101 PDCD6IP C1orf94 LITAF BAG4	1.73e-04	797	41	8	int:UBQLN2
Interaction	WWP1 interactions	EWSR1 PTPN21 LITAF CUEDC1 SEC23IP	1.76e-04	260	41	5	int:WWP1
Interaction	FAM168A interactions	RNF216 TNIP1 EWSR1 C1orf94	1.95e-04	142	41	4	int:FAM168A
Interaction	NUP35 interactions	RBM22 EWSR1 PDCD6IP RBM20 YLPM1 SEC23IP	2.02e-04	424	41	6	int:NUP35
Interaction	SNRPC interactions	SRRT PARD3B RBM22 EWSR1 BAG4 YLPM1	2.46e-04	440	41	6	int:SNRPC
Interaction	WWP2 interactions	EWSR1 PSMF1 TSG101 PDCD6IP LGALS9B LITAF BAG4 YLPM1	2.48e-04	840	41	8	int:WWP2
Interaction	ABI2 interactions	TNIP1 LGALS9B CASKIN2 BAG4 CUEDC1	2.74e-04	286	41	5	int:ABI2
Interaction	UMAD1 interactions	TNIP1 TSG101	3.11e-04	13	41	2	int:UMAD1
Interaction	THRSP interactions	TSG101 EIF4G3 BAG4	3.13e-04	65	41	3	int:THRSP
Interaction	RALYL interactions	RBM22 EWSR1 PSMF1	3.27e-04	66	41	3	int:RALYL
Interaction	EIF4ENIF1 interactions	RBM22 EWSR1 EIF4G3 BAG4 ALG13	3.42e-04	300	41	5	int:EIF4ENIF1
Interaction	ARRDC1 interactions	TSG101 PDCD6IP CUEDC1	3.57e-04	68	41	3	int:ARRDC1
Interaction	SP7 interactions	SRRT CHD7 RBM20 GPS2 YLPM1	3.63e-04	304	41	5	int:SP7
Interaction	EP300 interactions	SRRT HOXB1 IRF4 EWSR1 TSG101 SEC31A GPS2 MASP2 YLPM1 ALG13	3.91e-04	1401	41	10	int:EP300
Interaction	SNRPA interactions	SRRT TNIP1 RBM22 EWSR1 BAG4 YLPM1	4.01e-04	482	41	6	int:SNRPA
Interaction	SCGB3A1 interactions	TSG101 BAG4	4.17e-04	15	41	2	int:SCGB3A1
Cytoband	7q21	MAGI2 SRRT	6.03e-05	13	41	2	7q21
Cytoband	3p22.3	ARPP21 PDCD6IP	3.56e-04	31	41	2	3p22.3
Cytoband	14q24.3	NUMB YLPM1	3.16e-03	93	41	2	14q24.3
Cytoband	Ensembl 112 genes in cytogenetic band chr5q33	TNIP1 RBM22	5.03e-03	118	41	2	chr5q33
GeneFamily	Zinc fingers CCCH-type	ZC3H12B RBM22 MBNL3	2.35e-05	35	29	3	73
GeneFamily	Shisa family members	SHISA4 SHISA5	6.91e-05	8	29	2	742
GeneFamily	Galectins	LGALS9C LGALS9B	2.57e-04	15	29	2	629
GeneFamily	HOXL subclass homeoboxes	HOXB1 HOXD9	3.13e-03	52	29	2	518
GeneFamily	RNA binding motif containing	RBM22 EWSR1 RBM20	4.70e-03	213	29	3	725
GeneFamily	Sterile alpha motif domain containing	CASKIN2 SEC23IP	8.73e-03	88	29	2	760
Coexpression	GSE9601_UNTREATED_VS_NFKB_INHIBITOR_TREATED_HCMV_INF_MONOCYTE_DN	IRF4 CHD7 EIF4G3 PGAM2 SHISA5 YLPM1	2.50e-07	174	40	6	M6881
Coexpression	MORI_MATURE_B_LYMPHOCYTE_DN	LGALS9C EWSR1 LGALS9B LITAF	7.83e-06	83	40	4	MM596
Coexpression	GSE9650_EFFECTOR_VS_MEMORY_CD8_TCELL_UP	ZFYVE19 IRF4 CHD7 LGALS9B LITAF	1.27e-05	199	40	5	M5836
Coexpression	GSE13522_CTRL_VS_T_CRUZI_Y_STRAIN_INF_SKIN_IFNAR_KO_DN	RNF216 IRF4 TNIP1 LITAF CUEDC1	1.30e-05	200	40	5	M2930
Coexpression	WAKABAYASHI_ADIPOGENESIS_PPARG_BOUND_8D	LGALS9C NUMB IRF4 PSMF1 LGALS9B SHISA5 CUEDC1	6.48e-05	675	40	7	MM1073
Coexpression	DIRMEIER_LMP1_RESPONSE_LATE_UP	SRRT TNIP1 LITAF	8.63e-05	56	40	3	M4976
Coexpression	GSE9006_1MONTH_VS_4MONTH_POST_TYPE_1_DIABETES_DX_PBMC_DN	NUMB PSMF1 TSG101 MBNL3	2.24e-04	196	40	4	M5791
Coexpression	GSE360_L_MAJOR_VS_T_GONDII_MAC_UP	TNIP1 HOXD9 LITAF ALG13	2.29e-04	197	40	4	M5243
Coexpression	GSE37416_0H_VS_3H_F_TULARENSIS_LVS_NEUTROPHIL_UP	PSMF1 PDCD6IP SHISA5 BAG4	2.33e-04	198	40	4	M5341
Coexpression	GSE2770_TGFB_AND_IL4_VS_IL4_TREATED_ACT_CD4_TCELL_48H_UP	BTG3 EWSR1 TSG101 PDCD6IP	2.33e-04	198	40	4	M6112
Coexpression	GSE24142_DN2_VS_DN3_THYMOCYTE_DN	IRF4 ARPP21 SHISA5 MBNL3	2.38e-04	199	40	4	M4558
Coexpression	GSE360_L_DONOVANI_VS_B_MALAYI_LOW_DOSE_DC_UP	TNIP1 TSG101 LITAF GPS2	2.38e-04	199	40	4	M5203
Coexpression	GSE360_L_MAJOR_VS_B_MALAYI_LOW_DOSE_DC_UP	BTG3 TNIP1 LITAF GPS2	2.42e-04	200	40	4	M5211
Coexpression	GSE34006_WT_VS_A2AR_KO_TREG_UP	SRRT IRF4 EIF4G3 CUEDC1	2.42e-04	200	40	4	M9047
Coexpression	GSE20727_CTRL_VS_DNFB_ALLERGEN_TREATED_DC_UP	BTG3 RNF216 IRF4 PDCD6IP	2.42e-04	200	40	4	M9254
Coexpression	GSE40068_BCL6_POS_VS_NEG_CXCR5_POS_TFH_UP	RNF216 IRF4 PDCD6IP LGALS9B	2.42e-04	200	40	4	M9259
Disease	cortex volume change measurement	MAGI2 PARD3B	1.59e-04	15	37	2	EFO_0021500
Disease	Epileptic encephalopathy	MAGI2 ALG13	6.51e-04	30	37	2	C0543888
Disease	bitter beverage consumption measurement	MAGI2 SHISA5	1.28e-03	42	37	2	EFO_0010089
Disease	colorectal cancer, endometrial neoplasm	HOXB1 LITAF	1.28e-03	42	37	2	EFO_0004230, MONDO_0005575
Disease	QRS amplitude, QRS complex	LITAF RBM20	1.80e-03	50	37	2	EFO_0005054, EFO_0007742
Disease	eosinophil percentage of leukocytes	IRF4 TNIP1 CHD7 EIF4G3 MASP2	2.27e-03	746	37	5	EFO_0007991
Disease	diffuse plaque measurement	MAGI2 IRF4 TNIP1 PSMF1 C1orf94	2.44e-03	758	37	5	EFO_0010699
Disease	neutrophil percentage of granulocytes	IRF4 TNIP1 CHD7	2.91e-03	228	37	3	EFO_0007994
Disease	eosinophil percentage of granulocytes	IRF4 TNIP1 CHD7	3.14e-03	234	37	3	EFO_0007996
Disease	basophil count, eosinophil count	IRF4 TNIP1 CHD7	3.41e-03	241	37	3	EFO_0004842, EFO_0005090
Disease	S-7-hydroxywarfarin to S-warfarin ratio measurement	MAGI2 CUEDC1	4.66e-03	81	37	2	EFO_0803334
Disease	systemic scleroderma	TNIP1 CHD7	5.12e-03	85	37	2	EFO_0000717
Disease	nicotine dependence symptom count	PARD3B LITAF RBM20	5.44e-03	285	37	3	EFO_0009262
Disease	Neurodevelopmental Disorders	PARD3B ALG13	6.09e-03	93	37	2	C1535926

Protein segments in the cluster

Peptide	Gene	Start	Entry
GYPPSQNPGMTLPHY	BAG4	206	O95429
PGSYPMQPVTAPPSY	EWSR1	176	Q01844
YYPVMSDPYGQPPLP	ALG13	1066	Q9NP73
AQPPPHYGPTQPAYS	GPS2	191	Q13227
VQPNYPYPQRTPPKM	C1orf94	536	Q6P1W5
PMEVGSYPNMPHPQP	CHD7	421	Q9P2D1
PPPAQMPVYYYPSGQ	ARPP21	631	Q9UBL0
MNYDSQQPPLPPLPY	ZFYVE19	1	Q96K21
GPMWPPPHNQPYELY	RBM20	336	Q5T481
PPFMRAPGPIHYPSQ	RBM22	391	Q9NW64
MNPPSYYTQPAPIPN	LITAF	56	Q99732
PYYPGAHPMHPPKGS	PARD3B	1111	Q8TEW8
EMPSQPYPAPVYSQP	MAGI2	266	Q86UL8
PHPEIPYQCPMTFGP	IRF4	186	Q15306
TPAIPPMMYPHPAYP	LGALS9C	211	Q6DKI2
TPAIPPMMYPHPAYP	LGALS9B	211	Q3B8N2
MPYPPVYHQSPGQAP	PDCD6IP	831	Q8WUM4
EPPPVYSPPAYHMHV	CUEDC1	126	Q9NWM3
AMSGLYHPYVPPPPL	HOXD9	91	P28356
LPGQGPPPYVFMYPQ	CASKIN2	746	Q8WXE0
PPPYVFMYPQGSPSS	CASKIN2	751	Q8WXE0
PYVMPPPPQLHYNGH	PTPN21	336	Q16825
PGMPPAPQGRAPYHQ	ERVK-10	231	P87889
PYPPQHPPYGNEQTA	HOXB1	136	P14653
NPPMAFNPYIPHPGM	MBNL3	126	Q9NUK0
TAQPCPYPMAPPNGH	MASP2	296	O00187
PYPMAPPNGHVSPVQ	MASP2	301	O00187
MPYPVPQGPQYCIPQ	EIF4G3	56	O43432
PNPDHLPPPGYDDMY	PSMF1	256	Q92530
YPVANGMPYPAPNVP	NUMB	511	P49757
IPPPPMDEKHPYYNS	PGAM2	121	P15259
PMTGIPVQPVYPYPQ	SHISA4	131	Q96DD7
PPQPGMPAAPYPMQY	SHISA5	181	Q8N114
YPMQYPPPYPAQPMG	SHISA5	191	Q8N114
NLPQPQMPPYAFAHP	RNF216	791	Q9NWF9
AHPPPSGPPVQMYQM	SEC23IP	211	Q9Y6Y8
PYPHQTPQGLMPYGQ	SRRT	786	Q9BXP5
HQNHYPPPVPFGYPN	BTG3	201	Q14201
PPYQATGPPNTSYMP	TSG101	151	Q99816
GAYPYAYPPMPAMVP	TNIP1	546	Q15025
ADYPMPPNIHPGATP	ZC3H12B	676	Q5HYM0
SQSYMPPPQPPPSYY	YLPM1	161	P49750
PTPYPYYPKVHPGLM	ZNF366	171	Q8N895
YYPHGENPPPPGFIM	SEC31A	831	O94979