Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionisocitrate dehydrogenase [NAD(P)+] activity

IDH1 IDH2 IDH3A

3.13e-0651373GO:0004448
GeneOntologyMolecularFunctionisocitrate dehydrogenase (NADP+) activity

IDH1 IDH2

4.67e-0521372GO:0004450
GeneOntologyMolecularFunctionDNA (cytosine-5-)-methyltransferase activity, acting on CpN substrates

DNMT3A DNMT3B

4.67e-0521372GO:0051719
GeneOntologyMolecularFunctionsolute:monoatomic cation symporter activity

SLC12A8 SLC13A2 SLC6A1 SLC6A7 SLC39A12 SLC18A2

1.72e-041191376GO:0015294
GeneOntologyMolecularFunctionsecondary active transmembrane transporter activity

SLC9A9 SLC25A42 SLC12A8 SLC13A2 SLC6A1 SLC6A7 SLC39A12 SLC18A2 SLC9A7

2.09e-042961379GO:0015291
GeneOntologyMolecularFunctionDNA (cytosine-5-)-methyltransferase activity

DNMT3A DNMT3B

2.78e-0441372GO:0003886
GeneOntologyMolecularFunctionmetal ion transmembrane transporter activity

SLC9A9 SLC12A8 SLC13A2 SLC6A1 SLC6A7 SLC39A12 SLC18A2 MMGT1 SLC9A7 KCNN4 KCNMB3

3.69e-0446513711GO:0046873
GeneOntologyMolecularFunctioninorganic cation transmembrane transporter activity

SLC25A27 SLC9A9 SLC12A8 SLC13A2 RHAG SLC6A1 SLC6A7 SLC39A12 SLC18A2 MMGT1 SLC9A7 KCNN4 KCNMB3

3.86e-0462713713GO:0022890
GeneOntologyMolecularFunctiontransporter activity

TMEM30B SLC25A27 SLC9A9 SLC25A42 SLC38A9 SLC12A8 SLC13A2 RHAG SLC6A1 SLC6A7 SLC39A12 SLC18A2 MMGT1 SLC9A7 KCNN4 TMEM30A MFSD8 KCNMB3 SLC7A5P1 SLC27A4

5.06e-04128913720GO:0005215
GeneOntologyMolecularFunctionchloride:monoatomic cation symporter activity

SLC12A8 SLC6A1 SLC18A2

5.06e-04231373GO:0015377
GeneOntologyMolecularFunctionsymporter activity

SLC12A8 SLC13A2 SLC6A1 SLC6A7 SLC39A12 SLC18A2

5.96e-041501376GO:0015293
GeneOntologyMolecularFunctionN,N-dimethylaniline monooxygenase activity

FMO1 FMO6P

6.88e-0461372GO:0004499
GeneOntologyMolecularFunctioninorganic molecular entity transmembrane transporter activity

SLC25A27 SLC9A9 SLC12A8 SLC13A2 RHAG SLC6A1 SLC6A7 SLC39A12 SLC18A2 MMGT1 SLC9A7 KCNN4 MFSD8 KCNMB3

7.25e-0475813714GO:0015318
GeneOntologyMolecularFunctionmonoatomic anion:monoatomic cation symporter activity

SLC12A8 SLC6A1 SLC18A2

7.32e-04261373GO:0015296
GeneOntologyMolecularFunctionNADP binding

DPYD FMO1 IDH1 CRYZ

8.69e-04621374GO:0050661
GeneOntologyMolecularFunctionaminophospholipid flippase activity

TMEM30B TMEM30A

9.59e-0471372GO:0015247
GeneOntologyMolecularFunctionDNA-methyltransferase activity

DNMT3A DNMT3B

9.59e-0471372GO:0009008
GeneOntologyMolecularFunctionactive monoatomic ion transmembrane transporter activity

SLC9A9 SLC12A8 SLC13A2 SLC6A1 SLC6A7 SLC39A12 SLC18A2 SLC9A7

1.13e-033011378GO:0022853
GeneOntologyMolecularFunctionsodium ion transmembrane transporter activity

SLC9A9 SLC13A2 SLC6A1 SLC6A7 SLC18A2 SLC9A7

1.18e-031711376GO:0015081
GeneOntologyMolecularFunctiontransmembrane transporter activity

SLC25A27 SLC9A9 SLC25A42 SLC38A9 SLC12A8 SLC13A2 RHAG SLC6A1 SLC6A7 SLC39A12 SLC18A2 MMGT1 SLC9A7 KCNN4 MFSD8 KCNMB3 SLC7A5P1 SLC27A4

1.19e-03118013718GO:0022857
GeneOntologyMolecularFunctionmannosyl-oligosaccharide 1,2-alpha-mannosidase activity

MAN1A1 MAN1A2

1.27e-0381372GO:0004571
GeneOntologyMolecularFunctionNAD binding

IDH1 IDH2 IDH3A CRYZ

1.60e-03731374GO:0051287
GeneOntologyMolecularFunctionamine transmembrane transporter activity

RHAG SLC18A2

1.63e-0391372GO:0005275
GeneOntologyMolecularFunctionarginine binding

SLC38A9 CASTOR2

1.63e-0391372GO:0034618
GeneOntologyMolecularFunctionchloride transmembrane transporter activity

SLC25A27 SLC12A8 SLC6A1 SLC18A2 MFSD8

1.72e-031251375GO:0015108
GeneOntologyMolecularFunctionorganic acid:sodium symporter activity

SLC13A2 SLC6A1 SLC6A7

1.76e-03351373GO:0005343
GeneOntologyMolecularFunctionmannosyl-oligosaccharide mannosidase activity

MAN1A1 MAN1A2

2.03e-03101372GO:0015924
GeneOntologyMolecularFunctionmonoatomic cation transmembrane transporter activity

SLC25A27 SLC9A9 SLC12A8 SLC13A2 SLC6A1 SLC6A7 SLC39A12 SLC18A2 MMGT1 SLC9A7 KCNN4 KCNMB3

2.09e-0366413712GO:0008324
GeneOntologyMolecularFunctionsolute:sodium symporter activity

SLC13A2 SLC6A1 SLC6A7 SLC18A2

2.35e-03811374GO:0015370
GeneOntologyMolecularFunctionorganic cation transmembrane transporter activity

SLC25A42 SLC38A9 RHAG SLC6A7

2.56e-03831374GO:0015101
GeneOntologyMolecularFunctionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

FMO1 CYP4F2 FMO6P

2.59e-03401373GO:0016709
GeneOntologyMolecularFunctionoxidoreductase activity, acting on CH-OH group of donors

CYP4F2 AKR1A1 IDH1 IDH2 IDH3A

2.64e-031381375GO:0016614
GeneOntologyBiologicalProcesstricarboxylic acid metabolic process

ACLY IDH1 IDH2 IDH3A

5.46e-06181384GO:0072350
GeneOntologyBiologicalProcessisocitrate metabolic process

IDH1 IDH2 IDH3A

5.78e-0661383GO:0006102
GeneOntologyBiologicalProcessdicarboxylic acid metabolic process

GAD2 ACLY IDH1 IDH2 IDH3A KYAT3 ALDH4A1

9.80e-061111387GO:0043648
GeneOntologyBiologicalProcess2-oxoglutarate metabolic process

IDH1 IDH2 IDH3A KYAT3

1.05e-05211384GO:0006103
GeneOntologyBiologicalProcessorganic acid catabolic process

GAD2 AMT FMO1 LONP2 CYP4F2 AKR1A1 ADIPOQ KYAT3 ALDH4A1 SLC27A4

1.51e-0527213810GO:0016054
GeneOntologyBiologicalProcesscarboxylic acid catabolic process

GAD2 AMT FMO1 LONP2 CYP4F2 AKR1A1 ADIPOQ KYAT3 ALDH4A1 SLC27A4

1.51e-0527213810GO:0046395
GeneOntologyBiologicalProcesscarboxylic acid metabolic process

GAD2 DPYD SLC25A42 AMT FMO1 LONP2 ACLY CYP4F2 AKR1A1 IDH1 IDH2 IDH3A ADIPOQ UGT2A1 OSBPL6 ELOVL3 KYAT3 ALDH4A1 MFSD8 SLC27A4

1.85e-05103513820GO:0019752
GeneOntologyBiologicalProcessoxoacid metabolic process

GAD2 DPYD SLC25A42 AMT FMO1 LONP2 ACLY CYP4F2 AKR1A1 IDH1 IDH2 IDH3A ADIPOQ UGT2A1 OSBPL6 ELOVL3 KYAT3 ALDH4A1 MFSD8 SLC27A4

2.54e-05105813820GO:0043436
GeneOntologyBiologicalProcessorganic acid metabolic process

GAD2 DPYD SLC25A42 AMT FMO1 LONP2 ACLY CYP4F2 AKR1A1 IDH1 IDH2 IDH3A ADIPOQ UGT2A1 OSBPL6 ELOVL3 KYAT3 ALDH4A1 MFSD8 SLC27A4

2.75e-05106413820GO:0006082
GeneOntologyBiologicalProcessglyoxylate cycle

IDH1 IDH2

4.44e-0521382GO:0006097
GeneOntologyBiologicalProcesstricarboxylic acid cycle

ACLY IDH1 IDH2 IDH3A

8.55e-05351384GO:0006099
GeneOntologyBiologicalProcessmonocarboxylic acid metabolic process

GAD2 SLC25A42 FMO1 LONP2 ACLY CYP4F2 AKR1A1 IDH1 IDH2 ADIPOQ UGT2A1 OSBPL6 ELOVL3 MFSD8 SLC27A4

1.16e-0473113815GO:0032787
GeneOntologyBiologicalProcesssmall molecule catabolic process

GAD2 DPYD AMT FMO1 LONP2 CYP4F2 AKR1A1 ADIPOQ KYAT3 ALDH4A1 SLC27A4

1.27e-0442113811GO:0044282
GeneOntologyBiologicalProcesscardiac muscle thin filament assembly

NRAP NEB

1.33e-0431382GO:0071691
DomainIsocitrate/isopropylmalate_DH

IDH1 IDH2 IDH3A

3.34e-0651313IPR001804
DomainIso_dh

IDH1 IDH2 IDH3A

3.34e-0651313PF00180
DomainIsoCit/isopropylmalate_DH_CS

IDH1 IDH2 IDH3A

3.34e-0651313IPR019818
DomainIso_dh

IDH1 IDH2 IDH3A

3.34e-0651313SM01329
DomainIDH_IMDH

IDH1 IDH2 IDH3A

3.34e-0651313PS00470
DomainIsoPropMal-DH-like_dom

IDH1 IDH2 IDH3A

3.34e-0651313IPR024084
Domain-

IDH1 IDH2 IDH3A

3.34e-06513133.40.718.10
DomainIsocitrate_DH_NADP

IDH1 IDH2

4.88e-0521312IPR004790
DomainCDC50/LEM3_fam

TMEM30B TMEM30A

4.88e-0521312IPR005045
DomainCDC50

TMEM30B TMEM30A

4.88e-0521312PF03381
DomainG_DYNAMIN_dom

EHD2 MFN2 SRL

1.16e-04141313IPR030381
DomainG_DYNAMIN_2

EHD2 MFN2 SRL

1.16e-04141313PS51718
DomainDynamin_GTPase

EHD2 MFN2 SRL

1.44e-04151313IPR001401
DomainDynamin_SF

EHD2 MFN2 SRL

1.44e-04151313IPR022812
DomainDynamin_N

EHD2 MFN2 SRL

1.44e-04151313PF00350
DomainNa/H_exchanger_6

SLC9A9 SLC9A7

1.46e-0431312IPR002090
DomainNebulin

NRAP NEB

2.90e-0441312PF00880
DomainNEBULIN

NRAP NEB

2.90e-0441312PS51216
DomainC5_MTASE_1

DNMT3A DNMT3B

2.90e-0441312PS00094
DomainC5_MTASE_2

DNMT3A DNMT3B

2.90e-0441312PS00095
DomainSAM_MT_C5

DNMT3A DNMT3B

2.90e-0441312PS51679
DomainDNA_methylase

DNMT3A DNMT3B

2.90e-0441312PF00145
DomainNEBU

NRAP NEB

2.90e-0441312SM00227
DomainADD

DNMT3A DNMT3B

2.90e-0441312IPR025766
DomainNebulin

NRAP NEB

2.90e-0441312IPR013998
DomainC5_MeTfrase

DNMT3A DNMT3B

2.90e-0441312IPR001525
DomainC5_DNA_meth_AS

DNMT3A DNMT3B

2.90e-0441312IPR018117
DomainNebulin_repeat

NRAP NEB

2.90e-0441312IPR000900
DomainADD

DNMT3A DNMT3B

2.90e-0441312PS51533
DomainEHD_N

EHD2 SRL

4.82e-0451312IPR031692
DomainEHD_N

EHD2 SRL

4.82e-0451312PF16880
DomainFAD/NAD-binding_dom

DPYD FMO1 PPOX OSGIN1

6.85e-04571314IPR023753
DomainGlyco_hydro_47

MAN1A1 MAN1A2

1.00e-0371312PF01532
Domain-

MAN1A1 MAN1A2

1.00e-03713121.50.10.50
DomainGlyco_hydro_47

MAN1A1 MAN1A2

1.33e-0381312IPR001382
DomainNaH_exchanger

SLC9A9 SLC9A7

1.70e-0391312IPR004709
PathwayKEGG_MEDICUS_REFERENCE_CITRATE_CYCLE_FIRST_CARBON_OXIDATION

ACLY IDH1 IDH2 IDH3A

3.42e-0791044M47937
PathwayKEGG_CITRATE_CYCLE_TCA_CYCLE

ACLY IDH1 IDH2 IDH3A

7.55e-05311044M3985
PathwayWP_GLUTATHIONE_AND_ONECARBON_METABOLISM

AMT IDH1 DNMT3A DNMT3B

1.23e-04351044MM15815
PathwayKEGG_MEDICUS_REFERENCE_N_GLYCAN_BIOSYNTHESIS

MAN1A1 MAN1A2 MOGS

2.04e-04161043M47632
PathwayWP_TCA_CYCLE_AND_DEFICIENCY_OF_PYRUVATE_DEHYDROGENASE_COMPLEX_PDHC

ACLY IDH1 IDH3A

2.04e-04161043M39489
PathwayREACTOME_TRANSPORT_OF_BILE_SALTS_AND_ORGANIC_ACIDS_METAL_IONS_AND_AMINE_COMPOUNDS

SLC13A2 RHAG SLC6A1 SLC6A7 SLC18A2

2.42e-04761045MM15072
PathwayREACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS

SLC6A1 SLC6A7 SLC18A2

3.47e-04191043M27362
PathwayREACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS

SLC6A1 SLC6A7 SLC18A2

3.47e-04191043MM15107
PathwayBIOCARTA_ERAD_PATHWAY

MAN1A1 MAN1A2 MOGS

3.47e-04191043M22013
PathwayKEGG_N_GLYCAN_BIOSYNTHESIS

MAN1A1 MAN1A2 MOGS MGAT5B

3.60e-04461044M11079
PathwayREACTOME_SLC_MEDIATED_TRANSMEMBRANE_TRANSPORT

SLC9A9 SLC13A2 RHAG SLC6A1 SLC6A7 SLC18A2 SLC9A7 SLC27A4

3.75e-042381048MM15076
PathwayREACTOME_TRANSPORT_OF_BILE_SALTS_AND_ORGANIC_ACIDS_METAL_IONS_AND_AMINE_COMPOUNDS

SLC13A2 RHAG SLC6A1 SLC6A7 SLC18A2

3.86e-04841045M27334
PathwayREACTOME_SLC_MEDIATED_TRANSMEMBRANE_TRANSPORT

SLC9A9 SLC13A2 RHAG SLC6A1 SLC6A7 SLC18A2 SLC9A7 SLC27A4

5.07e-042491048M5988
PathwayREACTOME_N_GLYCAN_TRIMMING_AND_ELONGATION_IN_THE_CIS_GOLGI

MAN1A1 MAN1A2

5.31e-0451042M27954
PathwayREACTOME_N_GLYCAN_TRIMMING_AND_ELONGATION_IN_THE_CIS_GOLGI

MAN1A1 MAN1A2

5.31e-0451042MM15670
PathwayREACTOME_MTORC1_MEDIATED_SIGNALLING

SLC38A9 RRAGB EIF4G1

7.05e-04241043M3492
PathwayREACTOME_CA2_ACTIVATED_K_CHANNELS

KCNN4 KCNMB3

7.93e-0461042MM14543
PathwayREACTOME_MTORC1_MEDIATED_SIGNALLING

SLC38A9 RRAGB EIF4G1

7.97e-04251043MM14650
PathwayWP_NGLYCAN_BIOSYNTHESIS

MAN1A1 MAN1A2 MOGS MGAT5B

8.18e-04571044M48051
Pubmed

DNMT3A and IDH mutations in acute myeloid leukemia and other myeloid malignancies: associations with prognosis and potential treatment strategies.

IDH1 IDH2 DNMT3A

6.81e-083143324699305
Pubmed

Droplet digital polymerase chain reaction for DNMT3A and IDH1/2 mutations to improve early detection of acute myeloid leukemia relapse after allogeneic hematopoietic stem cell transplantation.

IDH1 IDH2 DNMT3A

6.81e-083143326703962
Pubmed

Association between IDH mutational status and tumor-associated epilepsy or venous thromboembolism in patients with grade II and III astrocytoma.

IDH1 IDH2 IDH3A

6.81e-083143334269949
Pubmed

Molecular evaluation of DNMT3A and IDH1/2 gene mutation: frequency, distribution pattern and associations with additional molecular markers in normal karyotype Indian acute myeloid leukemia patients.

IDH1 IDH2 DNMT3A

6.81e-083143324606448
Pubmed

Epigenetic Identity in AML Depends on Disruption of Nonpromoter Regulatory Elements and Is Affected by Antagonistic Effects of Mutations in Epigenetic Modifiers.

IDH1 IDH2 DNMT3A

6.81e-083143328408400
Pubmed

Mutation and expression analysis of the IDH1, IDH2, DNMT3A, and MYD88 genes in colorectal cancer.

IDH1 IDH2 DNMT3A

2.71e-074143324887488
Pubmed

GADD45A methylation predicts poor overall survival in acute myeloid leukemia and is associated with IDH1/2 and DNMT3A mutations.

IDH1 IDH2 DNMT3A

2.71e-074143323187294
Pubmed

Defining the membrane proteome of NK cells.

DPP4 MAN1A1 MYCBP2 LONP2 MED16 ACLY LEMD2 RECQL HUWE1 MAN1A2 MOGS HNRNPUL2 NBEAL2 HPS6 EIF4G1 MMGT1 TMEM30A CLINT1 SLC27A4

3.52e-0711681431919946888
Pubmed

Cooperating gene mutations in childhood acute myeloid leukemia with special reference on mutations of ASXL1, TET2, IDH1, IDH2, and DNMT3A.

IDH1 IDH2 DNMT3A

6.77e-075143323365461
Pubmed

Mutations of the epigenetics-modifying gene (DNMT3a, TET2, IDH1/2) at diagnosis may induce FLT3-ITD at relapse in de novo acute myeloid leukemia.

IDH1 IDH2 DNMT3A

6.77e-075143323135354
Pubmed

Influence of N-linked glycans in V4-V5 region of human immunodeficiency virus type 1 glycoprotein gp160 on induction of a virus-neutralizing humoral response.

MAN1A1 MAN1A2 MOGS MGAT5B

1.89e-062214348673525
Pubmed

Effect of various glycosidase treatments on the resistance of the HIV-1 envelope to degradation.

MAN1A1 MAN1A2 MOGS MGAT5B

1.89e-062214349109416
Pubmed

Folding of the human immunodeficiency virus type 1 envelope glycoprotein in the endoplasmic reticulum.

MAN1A1 MAN1A2 MOGS MGAT5B

1.89e-0622143411530211
Pubmed

Functional role of the glycan cluster of the human immunodeficiency virus type 1 transmembrane glycoprotein (gp41) ectodomain.

MAN1A1 MAN1A2 MOGS MGAT5B

2.28e-062314348093218
Pubmed

Glycosylation inhibitors block the expression of LAV/HTLV-III (HIV) glycoproteins.

MAN1A1 MAN1A2 MOGS MGAT5B

2.28e-062314343099781
Pubmed

Role of protein N-glycosylation in pathogenesis of human immunodeficiency virus type 1.

MAN1A1 MAN1A2 MOGS MGAT5B

2.28e-062314343264072
Pubmed

Role of asparagine-linked glycosylation in human immunodeficiency virus type 1 transmembrane envelope function.

MAN1A1 MAN1A2 MOGS MGAT5B

2.28e-062314341736542
Pubmed

Large-scale proteomics and phosphoproteomics of urinary exosomes.

DPP4 MAN1A1 ACLY TMEM59 ZG16B AKR1A1 IDH1 HUWE1 NEB SLC13A2 TF EHD2 CRYZ FCGBP MOGS MEGF8

4.78e-0610161431619056867
Pubmed

Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.

SLC25A27 SLC25A42 AMT ACLY COQ8B IDH1 IDH2 IDH3A NCOA4 PPOX C1QBP MFN2 KYAT3 ALDH4A1 IQCE

6.91e-069261431520877624
Pubmed

The human immunoglobulin kappa locus. Characterization of the duplicated A regions.

IGKV2D-30 IGKV2D-24 IGKV2-30

8.00e-061014331551402
Pubmed

Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy.

DPYD FMO1 FMO6P UGT2A1 ALDH4A1

8.00e-0666143519898482
Pubmed

Rewiring of the Human Mitochondrial Interactome during Neuronal Reprogramming Reveals Regulators of the Respirasome and Neurogenesis.

FKBP10 AMT ACLY IDH1 IDH2 IDH3A TF CRYZ MOGS C1QBP MMGT1 TMEM30A KYAT3 ALDH4A1

1.33e-058591431431536960
Pubmed

Role of oligosaccharides in the processing and maturation of envelope glycoproteins of human immunodeficiency virus type 1.

MAN1A1 MAN1A2 MOGS MGAT5B

1.63e-053714342541446
Pubmed

Metabolism unhinged: IDH mutations in cancer.

IDH1 IDH2

1.68e-052143221383741
Pubmed

Distinct enzymatic properties of recombinant mouse DNA methyltransferases Dnmt3a and Dnmt3b.

DNMT3A DNMT3B

1.68e-052143212869530
Pubmed

Local chromatin microenvironment determines DNMT activity: from DNA methyltransferase to DNA demethylase or DNA dehydroxymethylase.

DNMT3A DNMT3B

1.68e-052143226098813
Pubmed

IDH1 and IDH2 mutations in patients with acute myeloid leukemia: Suitable targets for minimal residual disease monitoring?

IDH1 IDH2

1.68e-052143230176240
Pubmed

Vorasidenib, a Dual Inhibitor of Mutant IDH1/2, in Recurrent or Progressive Glioma; Results of a First-in-Human Phase I Trial.

IDH1 IDH2

1.68e-052143234078652
Pubmed

IDH1/IDH2 mutations define the prognosis and molecular profiles of patients with gliomas: a meta-analysis.

IDH1 IDH2

1.68e-052143223894344
Pubmed

The PWWP domain of Dnmt3a and Dnmt3b is required for directing DNA methylation to the major satellite repeats at pericentric heterochromatin.

DNMT3A DNMT3B

1.68e-052143215456878
Pubmed

High incidence of IDH mutations in acute myeloid leukaemia with cuplike nuclei.

IDH1 IDH2

1.68e-052143221480859
Pubmed

Study of mutations in IDH1 and IDH2 genes in a sample of gliomas from Colombian population.

IDH1 IDH2

1.68e-052143229874711
Pubmed

Liver-specific deletion of de novo DNA methyltransferases protects against glucose intolerance in high-fat diet-fed male mice.

DNMT3A DNMT3B

1.68e-052143238795327
Pubmed

Selective anchoring of DNA methyltransferases 3A and 3B to nucleosomes containing methylated DNA.

DNMT3A DNMT3B

1.68e-052143219620278
Pubmed

p32 regulates ER stress and lipid homeostasis by down-regulating GCS1 expression.

MOGS C1QBP

1.68e-052143229465311
Pubmed

Molecular profiling of cholangiocarcinoma shows potential for targeted therapy treatment decisions.

IDH1 IDH2

1.68e-052143223391413
Pubmed

Inactivation of Dnmt3b in mouse embryonic fibroblasts results in DNA hypomethylation, chromosomal instability, and spontaneous immortalization.

DNMT3A DNMT3B

1.68e-052143215757890
Pubmed

Dnmt3a deficiency in the skin causes focal, canonical DNA hypomethylation and a cellular proliferation phenotype.

DNMT3A DNMT3B

1.68e-052143233846253
Pubmed

Highly specific determination of IDH status using edited in vivo magnetic resonance spectroscopy.

IDH1 IDH2

1.68e-052143229126125
Pubmed

Cancer-associated metabolite 2-hydroxyglutarate accumulates in acute myelogenous leukemia with isocitrate dehydrogenase 1 and 2 mutations.

IDH1 IDH2

1.68e-052143220142433
Pubmed

IDH1 and IDH2 mutations in gliomas.

IDH1 IDH2

1.68e-052143223532369
Pubmed

[IDH1/2 mutations in gliomas].

IDH1 IDH2

1.68e-052143222147457
Pubmed

DNA methylation and demethylation in mammals.

DNMT3A DNMT3B

1.68e-052143221454628
Pubmed

Profound flanking sequence preference of Dnmt3a and Dnmt3b mammalian DNA methyltransferases shape the human epigenome.

DNMT3A DNMT3B

1.68e-052143215854647
Pubmed

The prognostic value of IDH mutations and MGMT promoter status in secondary high-grade gliomas.

IDH1 IDH2

1.68e-052143223015095
Pubmed

Absence of IDH mutation in colorectal cancers with microsatellite instability.

IDH1 IDH2

1.68e-052143226987944
Pubmed

Pyrosequencing of IDH1 and IDH2 mutations in brain tumors and non-neoplastic conditions.

IDH1 IDH2

1.68e-052143223111198
Pubmed

Insular primary glioblastomas with IDH mutations: Clinical and biological specificities.

IDH1 IDH2

1.68e-052143228116838
Pubmed

Acquired mutations in the genes encoding IDH1 and IDH2 both are recurrent aberrations in acute myeloid leukemia: prevalence and prognostic value.

IDH1 IDH2

1.68e-052143220538800
Pubmed

IDH mutations in older patients with diffuse astrocytic gliomas.

IDH1 IDH2

1.68e-052143233137656
Pubmed

Molecular classification of diffuse cerebral WHO grade II/III gliomas using genome- and transcriptome-wide profiling improves stratification of prognostically distinct patient groups.

IDH1 IDH2

1.68e-052143225783747
Pubmed

DNA G-quadruplexes show strong interaction with DNA methyltransferases in vitro.

DNMT3A DNMT3B

1.68e-052143227468168
Pubmed

Type and location of isocitrate dehydrogenase mutations influence clinical characteristics and disease outcome of acute myeloid leukemia.

IDH1 IDH2

1.68e-052143223039322
Pubmed

Characterisation of isocitrate dehydrogenase 1/isocitrate dehydrogenase 2 gene mutation and the d-2-hydroxyglutarate oncometabolite level in dedifferentiated chondrosarcoma.

IDH1 IDH2

1.68e-052143231609487
Pubmed

Association of Maximal Extent of Resection of Contrast-Enhanced and Non-Contrast-Enhanced Tumor With Survival Within Molecular Subgroups of Patients With Newly Diagnosed Glioblastoma.

IDH1 IDH2

1.68e-052143232027343
Pubmed

Long-term survival in primary glioblastoma with versus without isocitrate dehydrogenase mutations.

IDH1 IDH2

1.68e-052143223918605
Pubmed

MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B.

DNMT3A DNMT3B

1.68e-052143217890317
Pubmed

IDH2 Mutation Analysis in Undifferentiated and Poorly Differentiated Sinonasal Carcinomas for Diagnosis and Clinical Management.

IDH1 IDH2

1.68e-052143231876581
Pubmed

IDH1 and IDH2 mutation analysis in Chinese patients with acute myeloid leukemia and myelodysplastic syndrome.

IDH1 IDH2

1.68e-052143221997850
Pubmed

Significance of IDH mutations varies with tumor histology, grade, and genetics in Japanese glioma patients.

IDH1 IDH2

1.68e-052143222136423
Pubmed

Isocitrate dehydrogenase (IDH) status prediction in histopathology images of gliomas using deep learning.

IDH1 IDH2

1.68e-052143232382048
Pubmed

Estimation of the occurrence rates of IDH1 and IDH2 mutations in gliomas and the reconsideration of IDH-wildtype anaplastic astrocytomas: an institutional experience.

IDH1 IDH2

1.68e-052143234162262
Pubmed

Differential prognostic impact of IDH1 and IDH2 mutations in chronic myelomonocytic leukemia.

IDH1 IDH2

1.68e-052143235351982
Pubmed

Integrative Genomic Analysis of Cholangiocarcinoma Identifies Distinct IDH-Mutant Molecular Profiles.

IDH1 IDH2

1.68e-052143228297679
Pubmed

Isocitrate dehydrogenase mutations in gliomas: mechanisms, biomarkers and therapeutic target.

IDH1 IDH2

1.68e-052143222002076
Pubmed

Adverse impact of IDH1 and IDH2 mutations in primary AML: experience of the Spanish CETLAM group.

IDH1 IDH2

1.68e-052143222520341
Pubmed

[IDH1- and IDH2-mutations in brain glial tumors - the new antioncogenic mechanism].

IDH1 IDH2

1.68e-052143229863707
Pubmed

Acute myeloid leukemia with isolated del(5q) is associated with IDH1/IDH2 mutations and better prognosis when compared to acute myeloid leukemia with complex karyotype including del(5q).

IDH1 IDH2

1.68e-052143231685963
Pubmed

IDH1 and IDH2 mutations are frequent events in central chondrosarcoma and central and periosteal chondromas but not in other mesenchymal tumours.

IDH1 IDH2

1.68e-052143221598255
Pubmed

Reprogramming of Isocitrate Dehydrogenases Expression and Activity by the Androgen Receptor in Prostate Cancer.

IDH1 IDH2

1.68e-052143231068457
Pubmed

The relationship between changes in serum myostatin and adiponectin levels in patients with obesity undergoing a weight loss program.

MSTN ADIPOQ

1.68e-052143234233657
Pubmed

A low-frequency variant at 8q24.21 is strongly associated with risk of oligodendroglial tumors and astrocytomas with IDH1 or IDH2 mutation.

IDH1 IDH2

1.68e-052143222922872
Pubmed

IDH Mutations in AML Patients; A higher Association with Intermediate Risk Cytogenetics.

IDH1 IDH2

1.68e-052143232212799
Pubmed

IDH mutations occur frequently in Chinese glioma patients and predict longer survival but not response to concomitant chemoradiotherapy in anaplastic gliomas.

IDH1 IDH2

1.68e-052143221874255
Pubmed

IDH1 and IDH2 mutations in myelodysplastic syndromes and role in disease progression.

IDH1 IDH2

1.68e-052143226228814
Pubmed

Co-deletion of chromosome 1p/19q and IDH1/2 mutation in glioma subsets of brain tumors in Chinese patients.

IDH1 IDH2

1.68e-052143222427879
Pubmed

Identification of additional IDH mutations associated with oncometabolite R(-)-2-hydroxyglutarate production.

IDH1 IDH2

1.68e-052143221996744
Pubmed

IDH mutation analysis in gliomas as a diagnostic and prognostic biomarker.

IDH1 IDH2

1.68e-052143223451940
Pubmed

Differential isocitrate dehydrogenase 1 and isocitrate dehydrogenase 2 mutation-related landscape in intrahepatic cholangiocarcinoma.

IDH1 IDH2

1.68e-052143238842680
Pubmed

A nonsense mutation of IDH1 in myelodysplastic syndromes and related disorders.

IDH1 IDH2

1.68e-052143220962861
Pubmed

Diagnostic utility of IDH1/2 mutations to distinguish dedifferentiated chondrosarcoma from undifferentiated pleomorphic sarcoma of bone.

IDH1 IDH2

1.68e-052143228552826
Pubmed

The oncometabolite D-2-hydroxyglutarate induced by mutant IDH1 or -2 blocks osteoblast differentiation in vitro and in vivo.

IDH1 IDH2

1.68e-052143226046462
Pubmed

The influence of DNMT3A and DNMT3B gene polymorphisms on acute myeloid leukemia risk in a Moroccan population.

DNMT3A DNMT3B

1.68e-052143232912818
Pubmed

Roles for Dnmt3b in mammalian development: a mouse model for the ICF syndrome.

DNMT3A DNMT3B

1.68e-052143216501171
Pubmed

Mutations in the isocitrate dehydrogenase genes IDH1 and IDH2 in tumors.

IDH1 IDH2

1.68e-052143223232569
Pubmed

Serum 2-hydroxyglutarate levels predict isocitrate dehydrogenase mutations and clinical outcome in acute myeloid leukemia.

IDH1 IDH2

1.68e-052143223641016
Pubmed

Distinct IDH1/IDH2 mutation profiles in purely insular versus paralimbic WHO Grade II gliomas.

IDH1 IDH2

1.68e-052143223330999
Pubmed

IDH1/2 Mutations in Sinonasal Undifferentiated Carcinomas : Previously Undescribed IDH2 R172K and R140x Variants.

IDH1 IDH2

1.68e-052143235486703
Pubmed

Metabolism of glioma and IDH1/IDH2 mutations.

IDH1 IDH2

1.68e-052143221885076
Pubmed

IDH1/2 Mutations in Cancer Stem Cells and Their Implications for Differentiation Therapy.

IDH1 IDH2

1.68e-052143234967233
Pubmed

Histopathological malignant progression of grade II and III gliomas correlated with IDH1/2 mutation status.

IDH1 IDH2

1.68e-052143222790483
Pubmed

IDH1 and IDH2 mutations in lung adenocarcinomas: Evidences of subclonal evolution.

IDH1 IDH2

1.68e-052143232333643
Pubmed

IDH1/2 mutations in acute myeloid leukemia patients and risk of coronary artery disease and cardiac dysfunction-a retrospective propensity score analysis.

IDH1 IDH2

1.68e-052143232948843
Pubmed

Mutant IDH: a targetable driver of leukemic phenotypes linking metabolism, epigenetics and transcriptional regulation.

IDH1 IDH2

1.68e-052143227431380
Pubmed

Methylation-independent repression of Dnmt3b contributes to oncogenic activity of Dnmt3a in mouse MYC-induced T-cell lymphomagenesis.

DNMT3A DNMT3B

1.68e-052143225639876
Pubmed

Functional evaluation of isocitrate dehydrogenase 1 and 2 variants of unclear significance in chronic myeloid neoplasms.

IDH1 IDH2

1.68e-052143231706195
Pubmed

Investigation of Isocitrate Dehydrogenase 1 and 2 Mutations in Acute Leukemia Patients in Saudi Arabia.

IDH1 IDH2

1.68e-052143234946913
Pubmed

Mutations of isocitrate dehydrogenase 1 and 2 in intrahepatic cholangiocarcinoma.

IDH1 IDH2

1.68e-052143224569570
Pubmed

Isocitrate dehydrogenase 1/2 mutational analyses and 2-hydroxyglutarate measurements in Wilms tumors.

IDH1 IDH2

1.68e-052143221225914
Pubmed

Cancer-associated IDH mutations: biomarker and therapeutic opportunities.

IDH1 IDH2

1.68e-052143220972461
Cytoband10q24.32

HPS6 ELOVL3 MFSD13A

5.83e-0524144310q24.32
GeneFamilySolute carriers

SLC25A27 SLC9A9 SLC25A42 SLC38A9 SLC12A8 SLC13A2 RHAG SLC6A1 SLC6A7 SLC39A12 SLC18A2 SLC9A7 SLC27A4

2.81e-083958313752
GeneFamilyMannosidases alpha class 1

MAN1A1 MAN1A2

1.24e-0448321193
GeneFamilyImmunoglobulin kappa locus at 2p11.2

IGKV2D-30 IGKV2D-24 IGKV2-30 IGKV2-24

5.76e-0483834351
GeneFamilyImmunoglobulin like domain containing

TMIGD2 IGSF5 SLAMF1 HMCN2 KIRREL1

1.95e-03193835594
GeneFamilyKallikreins

KLK14 KLK4

2.40e-0316832616
ToppCellproximal-Epithelial-Serous-3|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

NRAP ZG16B CCDC175 CHST1 SLC13A2 TF FCGBP KCNN4

2.45e-07195144806b73abc1f32543f2a51db52dc6424a2a398fe0f
ToppCellproximal-Epithelial-Serous|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

NRAP ZG16B CCDC175 CHST1 SLC13A2 TF FCGBP KCNN4

2.45e-071951448cb62f04f0e45bfb36eed2e7a3fc54d6d390b2ed1
ToppCellproximal-3-Epithelial-Serous|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

NRAP ZG16B CCDC175 CHST1 SLC13A2 TF FCGBP KCNN4

2.45e-07195144824a6a566143b04e37ad002e4c55037a0460ac2ef
ToppCellfacs-GAT-Fat-18m-Epithelial|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GAL3ST1 IGSF5 SLC13A2 TMEM171 FCGBP PRAP1 MS4A8

1.28e-061681447d6c8056b7d6b937bb91e6b33beeb1075dce1685c
ToppCellfacs-GAT-Fat-18m-Epithelial-epithelial_cell|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GAL3ST1 IGSF5 SLC13A2 TMEM171 FCGBP PRAP1 MS4A8

1.28e-0616814477102c52bf1b2ba67bb3700932181a2e0a6627711
ToppCellfacs-GAT-Fat-18m-Epithelial-nan|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GAL3ST1 IGSF5 SLC13A2 TMEM171 FCGBP PRAP1 MS4A8

1.28e-06168144768a2f9fd53b54023241acd1620cf24226f639c1b
ToppCell3'-GW_trimst-1.5-SmallIntestine-Epithelial-neuro-epithelial-K_cells_(GIP+)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TMEM30B GAD2 MAN1A1 RASSF10 LFNG TMEM171 MS4A8

1.81e-06177144743dce527392f3b8364bb6a55268ce9d6518d3a29
ToppCellfacs-Heart-RA-18m|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MAN1A1 MYCBP2 HNRNPUL1 MOGS HNRNPUL2 EIF4G1 CLINT1

1.88e-061781447b505e2550860e777535ee95f29c936242fd607f1
ToppCell3'-Airway_Nasal_SMG-Epithelial-Epithelial_transtional-secretory-SMG_acinar_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TMEM59 ZG16B SLC13A2 TF FCGBP PRAP1 KCNN4

2.18e-0618214472f7d9c0bf7155ac376e63fc9d9542b5c3ab89f04
ToppCell3'-Airway_Nasal_SMG-Epithelial-Epithelial_transtional-secretory-SMG_acinar_cell-SMG_duct|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TMEM59 ZG16B SLC13A2 TF FCGBP PRAP1 KCNN4

2.18e-0618214479b556e44ed6aaa50ec572224f5751fb02ce63438
ToppCell3'-Airway_Nasal_SMG-Epithelial-Epithelial_transtional-secretory-SMG_acinar_cell-SMG_duct-SMG_duct_L.0.6.2.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TMEM59 ZG16B SLC13A2 TF FCGBP PRAP1 KCNN4

2.34e-06184144700db9eaaffe9c598222e14b2f9638cbcce1602d7
ToppCell3'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-SMG_serous_secreting_cell-SMG_serous_(nasal)-SMG_serous_(nasal)_L.0.6.0.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TMEM59 ZG16B SLC13A2 TF FCGBP PRAP1 KCNN4

2.79e-06189144729423dc66a8af71293b2e1670acc6c34dfe63608
ToppCell3'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-SMG_serous_secreting_cell-SMG_serous_(nasal)|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TMEM59 ZG16B SLC13A2 TF FCGBP PRAP1 KCNN4

2.89e-061901447e3a07dcffb75375693738bef1668353f4cdba5d7
ToppCell3'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-SMG_serous_secreting_cell-SMG_serous_(nasal)-SMG_serous_(nasal)_L.0.6.0.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TMEM59 ZG16B SLC13A2 TF FCGBP PRAP1 KCNN4

2.89e-06190144770b14b649ae893513e6d61b7288d6f6df97f09d9
ToppCell3'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-SMG_serous_secreting_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TMEM59 ZG16B SLC13A2 TF FCGBP PRAP1 KCNN4

2.89e-061901447f6f8451eef5a387b0a1fd2e90ab965928ea2ea82
ToppCell3'-Broncho-tracheal_SMG-Epithelial-Epithelial_transtional-secretory-SMG_tracheobronchial_serous_cell-SMG_serous_(bronchial)-SMG_serous_(bronchial)_L.0.6.1.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ZG16B CHST1 SLC13A2 TF RHAG FCGBP KCNN4

2.99e-06191144713460059a0c1ed9f476cef28b8ad4c06349056c6
ToppCellTracheal-10x3prime_v2-Epithelial-Epi_submucosal-gland|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

NRAP ZG16B SLC13A2 TF FCGBP PRAP1 KCNN4

3.32e-061941447e90f6717e3421f8978d1fc1b2f30dcf69f6fcce7
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

FMO1 CYP4F2 AKR1A1 IDH1 SLC13A2 PRAP1 ALDH4A1

3.67e-0619714479b038dac4d4d306aa40ec07d79374c4fe9c604a6
ToppCellTracheal-10x3prime_v2-Epithelial-Epi_submucosal-gland-SMG_Mucous|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

NRAP ZG16B SLC12A8 TF FCGBP HNRNPUL2 KCNMB3

3.80e-0619814472ae9564da9913510141994262f3739eb095e0a68
ToppCellkidney_cells-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

DPP4 FMO1 AKR1A1 IDH1 SLC13A2 PRAP1 ALDH4A1

3.92e-0619914474bde35e5df019189433d65d415e29a0c1145ac66
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Astrocyte-Astrocyte-F|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

NRAP CHST1 SLC6A1 SLC39A12 MROH7 ALDH4A1 GPC5

4.06e-0620014477a8160e6477708f22e48c609bf8f43f3715dcb03
ToppCellwk_20-22-Epithelial-Proximal_epithelial-SMG_basal_1|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

ZG16B RASSF10 TF FCGBP PRAP1 KCNN4

1.27e-051581446adad97e6cf479d42791c5ba9cbc5f15f469322bf
ToppCellEntopeduncular-Endothelial-ENDOTHELIAL_STALK-Flt1_1-Endothelial_Stalk.Flt1.Gkn3_(Gkn3)--|Entopeduncular / BrainAtlas - Mouse McCarroll V32

PAPOLB MFSD6L TMEM171 KCNN4 OSGIN1

1.30e-0593144538a075f06001a2fd1ec77fc301a08a87618a2440
ToppCellEntopeduncular-Endothelial-ENDOTHELIAL_STALK-Flt1_1-Endothelial_Stalk.Flt1.Gkn3_(Gkn3)-|Entopeduncular / BrainAtlas - Mouse McCarroll V32

PAPOLB MFSD6L TMEM171 KCNN4 OSGIN1

1.30e-05931445a0117b12889d9c48294a7ccea4284d00c087889f
ToppCellEntopeduncular-Endothelial-ENDOTHELIAL_STALK-Flt1_1-Endothelial_Stalk.Flt1.Gkn3_(Gkn3)|Entopeduncular / BrainAtlas - Mouse McCarroll V32

PAPOLB MFSD6L TMEM171 KCNN4 OSGIN1

1.30e-05931445b3e057132633b25bd4f8ff2c0aa203ade0f3ba4c
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L6_LHX6_GLP1R|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GAD2 PCARE ARHGAP6 KLK4 KIRREL1 GPC5

1.93e-05170144640675b55269ffa57fb7fcdb903c81b02b4e01f8f
ToppCellEntopeduncular-Endothelial-ENDOTHELIAL_STALK-Flt1_1|Entopeduncular / BrainAtlas - Mouse McCarroll V32

DPP4 MFSD6L TMEM171 KCNN4 OSGIN1

2.03e-0510214452c3622fc3cd62d9b7e185d0204cf7f03e7dde73c
ToppCelldroplet-Limb_Muscle-nan-24m-Endothelial-unknown|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GAL3ST1 RASSF10 SLAMF1 MAP3K4 DNAH17 DNMT3B

2.50e-051781446f2002a5c4758d0af6c1880ca12f0af0d5e8888e4
ToppCell3'-Airway_Nasal_SMG-Epithelial-Epithelial_transtional-secretory-SMG_acinar_cell-SMG_duct-SMG_duct_L.0.6.2.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TMEM59 ZG16B SLC13A2 TF FCGBP KCNN4

2.58e-051791446ec331b1132f965581f851a3b29e62873c4140e6c
ToppCellCiliated_cells-A-Donor_08|World / lung cells shred on cell class, cell subclass, sample id

LKAAEAR1 ZG16B KATNAL1 OSBPL6 CFAP44 SLC27A4

2.58e-0517914461c41314b6fcfcac8d62034e7037570120d58f20f
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

DPYD MAN1A1 TCERG1L CCDC175 SLC6A7 MGAT5B

2.83e-05182144614a117c5e50db31ee1b2cf4df4d133451fd6d55f
ToppCelldroplet-Heart-nan-18m-Neuronal-nan|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GAL3ST1 IGSF5 ADIPOQ KCNN4 ELOVL3 CFAP44

2.92e-0518314461701c8c212f1fdb6e4764375542a203e19753d14
ToppCellcellseq-Epithelial-Epithelial_Glandular-Serous|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

ZG16B CHST1 SLC13A2 TF FCGBP KCNN4

3.01e-051841446f0cbb5b76e092be4188a9804ef5cf7a83cd7644f
ToppCellcellseq-Epithelial-Epithelial_Glandular-Serous-Serous|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

ZG16B CHST1 SLC13A2 TF FCGBP KCNN4

3.01e-0518414465433ba7bbab553ff668619822d1a9208e15cd59f
ToppCell3'-Broncho-tracheal_SMG-Epithelial-Epithelial_transtional-secretory-SMG_acinar_cell-SMG_duct-SMG_duct_L.0.6.2.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ZG16B CHST1 SLC13A2 FCGBP PRAP1 KCNN4

3.10e-051851446c4ca213a59ffab183a7719c2b4bc3f658a95002d
ToppCelldroplet-Heart-nan-18m-Neuronal|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GAL3ST1 IGSF5 ADIPOQ KCNN4 ELOVL3 CFAP44

3.10e-051851446c61267cfadea018794f7964904445787629a40d1
ToppCelldroplet-Heart-nan-18m-Neuronal-cardiac_neuron|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GAL3ST1 IGSF5 ADIPOQ KCNN4 ELOVL3 CFAP44

3.10e-0518514463a592719d5643011954f89d5bb61a5e94682b68e
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L3-4_PVALB_HOMER3|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GAD2 SLC9A9 PCARE SLC6A1 ARHGAP6 SRL

3.20e-051861446948815663c212c4311329d503b5991cbbbff9808
ToppCellfacs-Brain_Non-Myeloid-Striatum-3m-Macroglial-astrocyte|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CHST1 LCAT LFNG SLC6A1 SLC39A12 GPC5

3.20e-051861446ac7a84b11b4550c4ac01eab370dc8ab88e4fb72b
ToppCellfacs-Large_Intestine-Distal-24m-Epithelial-intestinal_crypt_stem_cell|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TMEM30B FMO1 IDH1 IDH3A C1QBP KCNN4

3.20e-051861446af038994a6c32261f426b0c40c39be4a9099fe43
ToppCell3'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-SMG_serous_secreting_cell-SMG_serous_(nasal)-SMG_serous_(nasal)_L.0.6.0.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TMEM59 ZG16B SLC13A2 TF RHAG KCNN4

3.40e-05188144602b3aae071ff1f469d52a4d513a4eb46ae70bba3
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L3-4_PVALB_HOMER3|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GAD2 SLC9A9 PCARE SLC6A1 ARHGAP6 SRL

3.40e-05188144672cbfe9dc0583dbeafa6cb0945fa370d0c808284
ToppCell3'-Airway_Nasal_SMG-Epithelial|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TMEM59 ZG16B SLC13A2 TF FCGBP KCNN4

3.50e-051891446a174f5757a53a68a753111a204efc1bb6da80d8b
ToppCell3'-Airway_Nasal_SMG|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TMEM59 ZG16B SLC13A2 TF FCGBP KCNN4

3.50e-051891446bb2b626645e9f060f0d99d05d1ea651fd8bc4945
ToppCell3'-Airway_Nasal_SMG-Epithelial-Epithelial_transtional-secretory|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TMEM59 ZG16B SLC13A2 TF FCGBP KCNN4

3.50e-05189144624741fe93438c1031fc5caa8837ef82d8d23f099
ToppCellfacs-Large_Intestine-Distal-24m-Epithelial-Lgr5+_undifferentiated_cell_(Distal)|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TMEM30B FMO1 IDH1 IDH3A C1QBP KCNN4

3.60e-051901446a124e1c12af70161b9ead5d677afa660610444ee
ToppCellfacs-Brain_Non-Myeloid-Cortex-3m-Macroglial-astrocyte|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CHST1 LCAT LFNG SLC6A1 SLC39A12 GPC5

3.71e-051911446fd345837bfc40d85256b9a7e4fd3343bcbfe0ae5
ToppCellfacs-Large_Intestine-Distal-3m-Epithelial-intestinal_crypt_stem_cell|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TMEM30B DPP4 ACLY IDH3A C1QBP KCNN4

3.71e-0519114467411b253b16e4d472be0925dee49188f0fd6b0b5
ToppCellfacs-Marrow-KLS-3m-Hematologic-MPP_Fraction_B_+_C|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADGRG3 IDH2 NCOA4 MOGS KCNN4 DNMT3B

3.82e-05192144603dcd9405d3d76fc7455066ba5d83c09cd17072d
ToppCell3'-Broncho-tracheal_SMG-Epithelial-Epithelial_transtional-secretory-SMG_tracheobronchial_serous_cell-SMG_serous_(bronchial)-SMG_serous_(bronchial)_L.0.6.1.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ZG16B CHST1 SLC13A2 TF FCGBP KCNN4

3.82e-05192144648b69d6f46e583378186d2993a202f9584688bfa
ToppCell3'-Broncho-tracheal_SMG-Epithelial-Epithelial_transtional-secretory-SMG_tracheobronchial_serous_cell-SMG_serous_(bronchial)|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ZG16B CHST1 SLC13A2 TF FCGBP KCNN4

3.93e-05193144656145861ef5e7655db9ad0d11b82f72dcadf285d
ToppCell3'-Broncho-tracheal_SMG-Epithelial-Epithelial_transtional-secretory-SMG_tracheobronchial_serous_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ZG16B CHST1 SLC13A2 TF FCGBP KCNN4

3.93e-0519314463d1710a6060d3a70994a206334ccb16cd63e5f20
ToppCellfacs-Marrow-KLS-18m-Hematologic-MPP_Fraction_B_+_C|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADGRG3 IDH2 MOGS KCNN4 MFSD13A DNMT3B

4.05e-051941446c9ebdcc2ea600975dade68a41fa65d1f8a5a5926
ToppCell3'-Broncho-tracheal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.4.4.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DPP4 TMEM59 AKR1A1 IDH1 UGT2A1 MS4A8

4.05e-05194144640251e6415a62fa55d86f2e8609bf0402e1c1abb
ToppCell3'-Broncho-tracheal_SMG-Epithelial|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ZG16B CHST1 SLC13A2 TF FCGBP KCNN4

4.05e-051941446f1d057c4bf57e75ad5a821e5f3de335dbff69062
ToppCell3'-Broncho-tracheal_SMG|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ZG16B CHST1 SLC13A2 TF FCGBP KCNN4

4.05e-05194144642558822d7e260e7d8cf2539f1f7426e5774edfb
ToppCell3'-Broncho-tracheal_SMG-Epithelial-Epithelial_transtional-secretory|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ZG16B CHST1 SLC13A2 TF FCGBP KCNN4

4.05e-0519414460d97dee07846416c77a861994912a9207f29ceb3
ToppCellcellseq-Epithelial-Epithelial_Glandular|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

ZG16B SLC13A2 TF FCGBP UGT2A1 KCNN4

4.05e-051941446d0fb1ff5cf0738881e114a58f0b27489f781d72b
ToppCell3'-Broncho-tracheal_SMG-Epithelial-Epithelial_transtional-secretory-SMG_tracheobronchial_serous_cell-SMG_serous_(bronchial)-SMG_serous_(bronchial)_L.0.6.1.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ZG16B CHST1 SLC13A2 TF FCGBP KCNN4

4.05e-051941446a8238f312a973cadf6eb29c1e02ba898c0a20412
ToppCell3'-Distal_airway-Epithelial-Epithelial_transtional-secretory-tracheobronchial_goblet_cell-Goblet_(subsegmental)|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DPP4 TMEM59 ZG16B FCGBP UGT2A1 MS4A8

4.16e-051951446576142b4e75457c0973051bccc4163bd624496af
ToppCell3'-Distal_airway-Epithelial-Epithelial_transtional-secretory-tracheobronchial_goblet_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DPP4 TMEM59 ZG16B FCGBP UGT2A1 MS4A8

4.16e-0519514468f151066ad3ebd9661ea0b733f03c2ce1518f9ad
ToppCellStriatum-Macroglia-ASTROCYTE-Gja1|Striatum / BrainAtlas - Mouse McCarroll V32

FMO1 LCAT SLC39A12 MROH7 GPC5

4.27e-051191445d47880ef1cff036192c43646a04fa8598dd7e1f4
ToppCellStriatum-Macroglia-ASTROCYTE|Striatum / BrainAtlas - Mouse McCarroll V32

FMO1 LCAT SLC39A12 MROH7 GPC5

4.27e-0511914450583387cc4497cf991fa42a81f2f66d9c6b774eb
ToppCellcellseq2|World / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

ZG16B CHST1 SLC13A2 TF FCGBP KCNN4

4.28e-051961446d9e1b8386817a668eca90288b6d0e20be4138bf8
ToppCellBronchial_Biopsy-Epithelial-Club|Bronchial_Biopsy / Tissue, Lineage and Cell class of Lung Cells from 10X

DPP4 ZG16B IDH1 SLC13A2 FCGBP UGT2A1

4.28e-051961446057d150bdf0cad959fd03ec2d1560a96ba03fae9
ToppCellBronchial_Biopsy-Epithelial-Club|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X

DPP4 ZG16B IDH1 SLC13A2 FCGBP UGT2A1

4.41e-0519714463f5dfa892a1f631b96eeb6f4cfc284aee51d1ce6
ToppCellkidney_cells-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

DPP4 FMO1 AKR1A1 IDH1 PRAP1 ALDH4A1

4.53e-051981446a9d72b17adfddb6ac1857c5f094280e86582693b
ToppCellParenchymal-10x5prime-Epithelial-Epi_airway_basal-Suprabasal|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

COL4A6 KLK14 TF SLC6A1 PLEKHH1 UGT2A1

4.53e-051981446de5987588b9fa9ee8c595ba06d7d844ead0e3c74
ToppCellkidney_cells-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

DPP4 FMO1 AKR1A1 IDH1 PRAP1 ALDH4A1

4.53e-051981446b933bd66f544822fcf1f2aa2d928c31500e2b3f4
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW19-Neuronal-Interneuron|GW19 / Sample Type, Dataset, Time_group, and Cell type.

GAD2 EHD2 SLC6A1 NBEAL2 DNMT3A

4.62e-051211445b2d571f571133c281d72584fe925cebbd2317829
ToppCellParenchymal-10x5prime-Epithelial-Epi_airway_secretory-Secretory_Goblet|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

ZG16B CDC20B SLC13A2 TF FCGBP UGT2A1

4.66e-0519914463c3133d0aa65338a576634def13e7f0f5c573a10
ToppCellParenchymal-10x5prime-Epithelial-Epi_airway_secretory|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

ZG16B KLK14 SLC13A2 TF FCGBP UGT2A1

4.66e-051991446a706ad5cd5e0dc8d7e925a05e45b07d35963f294
ToppCellBiopsy_Control_(H.)-Epithelial-MUC5AC+_High|Biopsy_Control_(H.) / Sample group, Lineage and Cell type

ZG16B IGSF5 MFSD6L SLC13A2 FCGBP UGT2A1

4.66e-051991446a5240868cea40574ed4ee45eb27a00c1812957ed
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

FMO1 CYP4F2 AKR1A1 SLC13A2 PRAP1 ALDH4A1

4.79e-052001446825aad08431dd6b54aa636ace6efc821dfaf8014
ToppCellSerous|World / shred by cell class for turbinate

ZG16B SLC13A2 FCGBP PRAP1 KCNN4

1.28e-0415014456a326662d58b0f17d6efa8cc28571f4cbbf57c2d
ToppCellPND07-28-samps-Myeloid-Macrophage-macrophage-C|PND07-28-samps / Age Group, Lineage, Cell class and subclass

KLK14 PIWIL2 MROH7 PAX4

1.32e-048014443413ac5e1c1e59eab6a83b889b870a8db4efccb9
ToppCelldroplet-Lung-30m-Hematologic-myeloid-Basophil/Mast_cell-basophil_l14|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ADGRG3 GAL3ST1 COQ8B PIWIL2 SLC18A2

1.36e-0415214450fda8980b10ce16179dea92301db74d728f41794
ToppCell390C-Lymphocytic-NK_cells-NK_cell_D2|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

TMIGD2 ZG16B MS4A8 OSGIN1 DNMT3B

1.36e-041521445595afcfa8b161e291fcaf2afc7336bac9b6fae0f
ToppCell18-Airway-Epithelial-Goblet-like_secretory|Airway / Age, Tissue, Lineage and Cell class

ZG16B PLPP7 MFSD6L TF FCGBP

1.40e-04153144514a60220e169ce642771636de982a7b02e5b2608
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Degenerative_Connecting_Tubule_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

TMEM30B MFSD6L CYP4F2 IDH2 DMAC1

1.44e-041541445dcbc6705e91ec744801b621e5d0733a78a7a90ca
ToppCell343B-Lymphocytic-CD4_T-cell-Treg_cell_1|343B / Donor, Lineage, Cell class and subclass (all cells)

ZG16B SLAMF1 LFNG HNRNPUL2 DMAC1

1.49e-041551445a4ff78e2efc6fe9a513bb2b64e5848f2ce65a09f
ToppCellsaliva-Severe-critical_progression_d28-40-Myeloid-Macrophage-macrophage,_alveolar-Macro_c6-VCAN|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)

SLC25A42 AMT KATNAL1 ADIPOQ MROH7

1.73e-0416014458374ae912337947b2cc8d17d5840f306361fe1ff
ToppCellClub-club-13|World / Class top

FMO1 AKR1A1 IDH1 IDH2 SLC9A7

1.83e-0416214457d18f05a65ac715e62d610df9cc4a26539340dee
ToppCellPND07-28-samps-Epithelial-Epithelial-non_alveolar-Club_cell|PND07-28-samps / Age Group, Lineage, Cell class and subclass

AMT MOGS HPS6 UGT2A1 OSGIN1

1.83e-041621445aed15eef32419b8a4e2afdb9776c2bf2802e96f1
ToppCellTCGA-Head_and_Esophagus-Solid_Tissue_Normal-Head_and_Neck-Head_and_Neck_normal_tissue-2|TCGA-Head_and_Esophagus / Sample_Type by Project: Shred V9

ZG16B SLC13A2 MSTN FMO6P ADIPOQ

1.88e-0416314452dfd11f5803822ba01b92adf4395a3b3adda68f5
ToppCellfacs-Heart-RA-18m-Myeloid-macrophage|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IGSF5 SLC13A2 TMEM171 PRAP1 MS4A8

1.88e-04163144513557be854878abc1bcdab909b49b8292d064145
ToppCellfacs-Heart-RA-18m-Myeloid-macrophage|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IGSF5 SLC13A2 TMEM171 PRAP1 MS4A8

1.88e-0416314456c1d1646410e785886d2de103b4b12f73e91edff
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Lamp5-Lamp5_Lsp1|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

GAD2 FMO1 SLC6A1 ARHGAP6 KIRREL1

1.88e-041631445bba830a302919c8b33f914a8839877fc21dd28a0
ToppCell11.5-Airway-RBC-RBC|Airway / Age, Tissue, Lineage and Cell class

ADGRG3 TF RHAG SLC18A2 KCNN4

1.99e-0416514458618b2c5659aa70c7c9d6e51a227ac612b4ad17b
ToppCell11.5-Airway-RBC|Airway / Age, Tissue, Lineage and Cell class

ADGRG3 TF RHAG SLC18A2 KCNN4

1.99e-04165144546042340a373adaf1c439b2301e02fbae3e31a4f
ToppCellClub-club-2|World / Class top

FMO1 IDH2 SLC13A2 FCGBP OSGIN1

2.05e-04166144556f11efb6b686b3ee2c34a051f626e3d761b5112
ToppCell3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-tracheobronchial_goblet_cell-Goblet_(subsegmental)-Goblet_(subsegmental)_L.0.4.3.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TMEM59 ZG16B TF FCGBP UGT2A1

2.11e-04167144531633899aae852873a4887e72c621474b0a51a33
ToppCellfacs-Lung-18m-Hematologic-lymphocytic-regulatory_T_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

GAD2 NEB SLAMF1 KCNN4 SOHLH1

2.16e-0416814452d2eab3190374f79f373e31c8b062ff4e1766396
ToppCellfacs-Lung-18m-Hematologic-lymphocytic-regulatory_T_cell-regulatory_T_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

GAD2 NEB SLAMF1 KCNN4 SOHLH1

2.16e-041681445df58156721457b34af1e81c0eb8a7243cbbfb303
ToppCellPND28-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

COL4A6 NRAP RNF112 RRAGB SRL

2.23e-04169144588aa2246ede582c2e11de63228d76f520889ecb3
ToppCellTCGA-Liver-Primary_Tumor-Hepatocellular_Carcinoma-Hepatocellular_Carcinoma-4|TCGA-Liver / Sample_Type by Project: Shred V9

GAL3ST1 SLC13A2 ZNF850 DNMT3A DNMT3B

2.23e-0416914450a3ba6b5d6cff9d3d7f56046063cfc3a37ae1156
ToppCell343B-Lymphocytic-NK_cells-NK_cell_B0|NK_cells / Donor, Lineage, Cell class and subclass (all cells)

DPP4 IGHV1-69-2 SLAMF1 ARHGAP6 OSBPL6

2.23e-04169144589b5452e0d8d058648a1d2659f1611fd6aebc6b6
ToppCellPND28-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-ASMC|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

COL4A6 NRAP RNF112 RRAGB SRL

2.23e-041691445a6a5b00912b653fad2ca7f096deaf35c9ef85e5b
ToppCellfacs-Lung-24m-Hematologic-myeloid-classical_monocyte-classical_monocyte_l14|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SLC25A42 IDH1 NEB MFN2 MS4A8

2.23e-041691445813472d429c0b12580b17b440e00a6d8beb7947f
ToppCellPND28-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-ASMC-ASMC_mature|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

COL4A6 NRAP RNF112 RRAGB SRL

2.23e-04169144542a9b8c77d2a4d68b01e4db38f8a1af53c9c814f
ComputationalOrganic acid metabolism.

GAD2 AMT CYP4F2 IDH1 IDH2 ALDH4A1

2.17e-0582756MODULE_40
ComputationalGenes in the cancer module 286

IDH1 IDH2 IDH3A CRYZ

1.21e-0437754MODULE_286
ComputationalOxidoreductases.

AKR1A1 IDH1 IDH2

1.40e-0415753MODULE_519
DrugAC1NRATE

DPP4 MAN1A1 GAL3ST1 SLC6A1 MAN1A2 MOGS SLC18A2

7.29e-07831387CID005288086
DrugC015407

IDH1 IDH2 IDH3A TF

8.85e-07131384CID003014226
Drug3-amino-2-oxopropyl phosphate

IDH1 IDH2 IDH3A

2.16e-0651383CID000000005
Drug3-ethylmalate

IDH1 IDH2 IDH3A

2.16e-0651383CID000439619
DrugBDTD

IDH1 IDH2 IDH3A

2.16e-0651383CID003036435
Drugadenosine 5'-(2-bromoethyl)-phosphate

IDH1 IDH2 IDH3A

2.16e-0651383CID000194660
Drugbromoketoglutarate

IDH1 IDH2 IDH3A

4.30e-0661383CID000195934
Drugbumetanide

DPYD SLC9A9 KLK14 SLC12A8 SLC13A2 SLC6A1 KLK4 SLC9A7 KCNN4

5.37e-062091389CID000002471
DrugMetazamide

IDH1 IDH2 IDH3A

7.49e-0671383CID000026433
Drug8-BDB-TNAD

IDH1 IDH2 IDH3A

7.49e-0671383CID000170328
Drugcitrazinic acid

IDH1 IDH2 IDH3A

1.19e-0581383CID000007425
DrugAsparagusate

IDH1 IDH2 IDH3A

1.78e-0591383CID000016682
DrugAC1N02M5

IDH1 IDH2 IDH3A

1.78e-0591383CID003956233
DrugDapsone [80-08-0]; Down 200; 16.2uM; PC3; HT_HG-U133A

COL4A6 IDH2 CEP68 ARHGAP6 HNRNPUL2 ALDH4A1 CFAP44 IQCE

2.57e-0519513885078_DN
DrugMefexamide hydrochloride [3413-64-7]; Up 200; 12.6uM; PC3; HT_HG-U133A

DPP4 APBB1 WDR91 RAB28 KIRREL1 ALDH4A1 MFSD13A DNMT3B

2.57e-0519513882121_UP
DrugPindolol [13523-86-9]; Up 200; 16.2uM; PC3; HT_HG-U133A

FKBP10 DPP4 LONP2 MED16 ARHGAP6 RAB28 MFN2 ALDH4A1

2.77e-0519713882075_UP
Drugbeta-NADP

DPYD AMT FMO1 ACLY CYP4F2 AKR1A1 IDH1 IDH2 IDH3A FMO6P CRYZ ALDH4A1

4.53e-0549013812CID000000929
Drug2-isopropylmalate

IDH1 IDH2 IDH3A

4.61e-05121383CID000000036
Drug1,3-butanedione

IDH1 IDH2 IDH3A

4.61e-05121383CID000022747
Drughomoisocitric acid

IDH1 IDH2 IDH3A

4.61e-05121383CID005119182
DrugAC1L19KJ

IDH1 IDH2 IDH3A

4.61e-05121383CID000000589
Drughydride

GAD2 DPYD SLC9A9 AMT FMO1 CYP4F2 AKR1A1 IDH1 IDH2 IDH3A SLC13A2 PPOX CRYZ SLC18A2 SLC9A7 ALDH4A1

4.78e-0583513816CID000000783
Drugmagnesium citrate

IDH1 IDH2 IDH3A

7.55e-05141383CID000008949
Drugalpha-methylisocitrate

IDH1 IDH2 IDH3A

7.55e-05141383CID000000513
Diseasehepatocellular clear cell carcinoma (is_implicated_in)

IDH1 IDH2

2.05e-0521342DOID:5016 (is_implicated_in)
DiseaseChondroma

IDH1 IDH2

2.05e-0521342C0936248
DiseaseEnchondroma

IDH1 IDH2

2.05e-0521342C1704356
Diseaseendometriosis of uterus (is_marker_for)

DNMT3A DNMT3B

6.12e-0531342DOID:288 (is_marker_for)
DiseaseMaffucci Syndrome

IDH1 IDH2

6.12e-0531342C0024454
DiseaseEnchondromatosis

IDH1 IDH2

1.22e-0441342C0014084
DiseaseHemangioma, Intramuscular

IDH1 IDH2

1.22e-0441342C0205789
DiseaseHistiocytoid hemangioma

IDH1 IDH2

1.22e-0441342C0205788
DiseaseChorioangioma

IDH1 IDH2

1.22e-0441342C0677608
DiseaseAngioma

IDH1 IDH2

1.22e-0441342C1959588
DiseaseAngioimmunoblastic Lymphadenopathy

IDH2 DNMT3A

1.22e-0441342C0020981
DiseaseHemangioma

IDH1 IDH2

1.22e-0441342C0018916
Diseasecongenital heart disease (biomarker_via_orthology)

DNMT3A DNMT3B

1.22e-0441342DOID:1682 (biomarker_via_orthology)
DiseaseBiliary Tract Neoplasm

IDH1 IDH2

3.03e-0461342C0005426
DiseaseChildhood Oligodendroglioma

IDH1 IDH2

4.24e-0471342C0280475
DiseaseAdult Oligodendroglioma

IDH1 IDH2

4.24e-0471342C0279070
DiseaseOligodendroblastoma

IDH1 IDH2

4.24e-0471342C0344461
DiseaseMixed Oligodendroglioma-Astrocytoma

IDH1 IDH2

4.24e-0471342C0280793
DiseaseMixed Oligodendroglioma-Ependymoma

IDH1 IDH2

4.24e-0471342C0751395
DiseaseWell Differentiated Oligodendroglioma

IDH1 IDH2

4.24e-0471342C0751396
Diseasefatty liver disease (biomarker_via_orthology)

ADIPOQ MFN2 SLC27A4

4.52e-04331343DOID:9452 (biomarker_via_orthology)
Diseaseoligodendroglioma

IDH1 IDH2

5.63e-0481342C0028945
Diseaseresponse to vitamin

CYP4F2 SLC6A1

5.63e-0481342GO_0033273
DiseaseAnaplastic Oligodendroglioma

IDH1 IDH2

5.63e-0481342C0334590
DiseaseGrowth Disorders

RNF135 IDH2 DNMT3A

5.86e-04361343C0018273
Diseaseacute myeloid leukemia (is_implicated_in)

IDH1 IDH2 DNMT3A DNMT3B

5.92e-04841344DOID:9119 (is_implicated_in)
DiseaseNeoplasm Recurrence, Local

IDH1 IDH2 DNMT3A

7.43e-04391343C0027643
DiseasePeripheral T-Cell Lymphoma

IDH2 DNMT3A

8.99e-04101342C0079774
DiseaseGeneralized seizures

GAD2 IDH2 SLC6A1 MIB1

1.18e-031011344C0234533
DiseaseClonic Seizures

GAD2 IDH2 SLC6A1 MIB1

1.18e-031011344C0234535
DiseaseConvulsive Seizures

GAD2 IDH2 SLC6A1 MIB1

1.18e-031011344C0751494
DiseaseSeizures, Sensory

GAD2 IDH2 SLC6A1 MIB1

1.18e-031011344C0751496
DiseaseNon-epileptic convulsion

GAD2 IDH2 SLC6A1 MIB1

1.18e-031011344C0751056
DiseaseAtonic Absence Seizures

GAD2 IDH2 SLC6A1 MIB1

1.18e-031011344C0751123
DiseaseComplex partial seizures

GAD2 IDH2 SLC6A1 MIB1

1.18e-031011344C0149958
DiseaseSingle Seizure

GAD2 IDH2 SLC6A1 MIB1

1.18e-031011344C0751110
DiseaseNonepileptic Seizures

GAD2 IDH2 SLC6A1 MIB1

1.18e-031011344C3495874
DiseaseVisual seizure

GAD2 IDH2 SLC6A1 MIB1

1.18e-031011344C0270824
DiseaseEpileptic drop attack

GAD2 IDH2 SLC6A1 MIB1

1.18e-031011344C0270846
DiseaseVertiginous seizure

GAD2 IDH2 SLC6A1 MIB1

1.18e-031011344C0422855
DiseaseGustatory seizure

GAD2 IDH2 SLC6A1 MIB1

1.18e-031011344C0422854
DiseaseSeizures, Somatosensory

GAD2 IDH2 SLC6A1 MIB1

1.18e-031011344C0422850
DiseaseOlfactory seizure

GAD2 IDH2 SLC6A1 MIB1

1.18e-031011344C0422853
DiseaseSeizures, Auditory

GAD2 IDH2 SLC6A1 MIB1

1.18e-031011344C0422852
DiseaseGeneralized Absence Seizures

GAD2 IDH2 SLC6A1 MIB1

1.18e-031011344C4505436
DiseaseJacksonian Seizure

GAD2 IDH2 SLC6A1 MIB1

1.18e-031011344C0022333
Diseaseobesity (is_marker_for)

ADIPOQ MFN2 PRL SLC27A4

1.18e-031011344DOID:9970 (is_marker_for)
DiseaseEpileptic Seizures

GAD2 IDH2 SLC6A1 MIB1

1.18e-031011344C4317109
DiseaseAcute Promyelocytic Leukemia

IDH1 IDH2 DNMT3A

1.21e-03461343C0023487
DiseaseAbsence Seizures

GAD2 IDH2 SLC6A1 MIB1

1.23e-031021344C4316903
DiseaseConvulsions

GAD2 IDH2 SLC6A1 MIB1

1.23e-031021344C4048158
DiseaseTonic Seizures

GAD2 IDH2 SLC6A1 MIB1

1.23e-031021344C0270844
Diseaseprostatitis (biomarker_via_orthology)

DNMT3A DNMT3B

1.31e-03121342DOID:14654 (biomarker_via_orthology)
Diseasepolycystic ovary syndrome (is_marker_for)

NCOA4 ADIPOQ

1.31e-03121342DOID:11612 (is_marker_for)
DiseaseHematologic Neoplasms

IDH1 IDH2

1.31e-03121342C0376545
DiseaseSeizures, Focal

GAD2 IDH2 SLC6A1 MIB1

1.32e-031041344C0751495
DiseaseMyoclonic Seizures

GAD2 IDH2 SLC6A1 MIB1

1.32e-031041344C4317123
DiseaseTonic - clonic seizures

GAD2 IDH2 SLC6A1 MIB1

1.32e-031041344C0494475
Diseaseautoimmune thrombocytopenic purpura (is_marker_for)

DNMT3A DNMT3B

1.55e-03131342DOID:8924 (is_marker_for)
DiseaseCongestive heart failure

ACLY MSTN ADIPOQ PRL

1.62e-031101344C0018802
DiseaseHeart failure

ACLY MSTN ADIPOQ PRL

1.62e-031101344C0018801
DiseaseLeft-Sided Heart Failure

ACLY MSTN ADIPOQ PRL

1.62e-031101344C0023212
DiseaseHeart Failure, Right-Sided

ACLY MSTN ADIPOQ PRL

1.62e-031101344C0235527
DiseaseHeart Decompensation

ACLY MSTN ADIPOQ PRL

1.62e-031101344C1961112
DiseaseMyocardial Failure

ACLY MSTN ADIPOQ PRL

1.62e-031101344C1959583
Diseaseearly cardiac repolarization measurement

MYCBP2 MGAT5B

1.80e-03141342EFO_0004885
Diseasenicotine dependence symptom count

DPYD MYCBP2 SLC38A9 EYA3 TF MGAT5B

1.97e-032851346EFO_0009262
DiseaseDyschondroplasias

IDH1 IDH2

3.33e-03191342C0013366
Diseaseestrogen-receptor negative breast cancer

CASTOR2 C19orf12 KCNN4

4.18e-03711343EFO_1000650
Diseasetype 1 diabetes mellitus (is_marker_for)

ADIPOQ SLC18A2 DNMT3B

4.35e-03721343DOID:9744 (is_marker_for)
Diseasefat intake measurement

NRAP DNMT3A

4.46e-03221342EFO_0010809

Protein segments in the cluster

PeptideGeneStartEntry
GIATWGIVVMADPKG

DMAC1

96

Q96GE9
PMSNLWLKGDKGSQG

COL4A6

961

Q14031
LLGAWMTSGQFKPVP

C19orf12

71

Q9NSK7
QTLAMGIVIDWAPKG

ERVK13-1

81

Q9NX77
TLPKMSGGWELELNG

C1QBP

101

Q07021
RVPQKQGGMGLASWS

CEP68

381

Q76N32
MIEWALGGFQPSGPK

DNMT3A

406

Q9Y6K1
WGNLPGMNRPVIASK

DNMT3B

736

Q9UBC3
GVLLPLPKGACTGWM

ADIPOQ

26

Q15848
MVGTKLPNSVLGRIW

EHD2

476

Q9NZN4
GELWKMVRIGGQPLG

CASTOR2

261

A6NHX0
GAPALMGNVVLWKPS

ALDH4A1

221

P30038
GWGLPALMVIGTGSA

ADGRG3

386

Q86Y34
LMGLKSDGTPWPAVG

DPYD

741

Q12882
PMSGGWGEGKDLLLQ

APBB1

411

O00213
LPDGKVLSGSEWGNM

CFAP44

331

Q96MT7
KSILEALGPWMNSGK

MROH7

561

Q68CQ1
MWVDQARGLAKSGPG

RASSF10

466

A6NK89
IWDIGGQTIGGKMLD

RAB28

66

P51157
LQAGMEIGWLKPVIG

CRYZ

286

Q08257
GALWPGMKPESGLIQ

EYA3

121

Q99504
MPLGGRASLTPQKLW

IQCE

66

Q6IPM2
WLTASGSGARILGPM

MFSD8

456

Q8NHS3
SGWGLLANGRMPTVL

KLK4

151

Q9Y5K2
TMWVIGLGLKKPDNS

PAPOLB

436

Q9NRJ5
LGNSLMAPVGRWQKG

MMTAG2

31

Q9BU76
LKKMREIIGWPGGSG

GAD2

221

Q05329
QLLGLLMLWVPGSSG

IGKV2D-30

6

A0A075B6S6
VAIGLAWTPLGGEIM

LONP2

656

Q86WA8
ISRGLALKMSPWASG

LFNG

261

Q8NES3
PWGPSGQLMGEIAKA

CLINT1

36

Q14677
AGWALVLAGTGIGLM

KCNN4

26

O15554
LIGMKGIGWLALRSP

NRAP

1416

Q86VF7
LGSGTWPSAPKMFLL

KLK14

6

Q9P0G3
LGILWVKMGKPSAPQ

LEMD2

226

Q8NC56
PDKWELLQLGSGGGM

GPC5

476

P78333
TLMWLKDGNPVSPAG

HMCN2

2016

Q8NDA2
PGKMLAMGALAGFWI

ARSJ

21

Q5FYB0
LKGGPLGEMVQWADI

MGAT5B

306

Q3V5L5
LGLAAPWVGTLMGTK

MFSD6L

41

Q8IWD5
QLLGLLMLWVPGSSG

IGKV2D-24

6

A0A075B6R9
LKEAGSPGLALVMWA

SLC7A5P1

76

Q8MH63
LMVGLPGSGKTQWAL

HNRNPUL2

456

Q1KMD3
ATLWMFGGLGLPQGL

MEGF8

1521

Q7Z7M0
KPGWALTPQGLAAML

LKAAEAR1

41

Q8TD35
MKTPWKVLLGLLGAA

DPP4

1

P27487
MGPGKWDGARNAILT

FMO6P

481

O60774
VQQAPGKGLEWMGLV

IGHV1-69-2

56

A0A0G2JMI3
SSVPQMLINLWGPGK

OR2C1

76

O95371
MLINLWGPGKTISYG

OR2C1

81

O95371
NWALSMGGKVPVSEG

HUWE1

1171

Q7Z6Z7
WGKSMEILPVGTLNV

OSBPL6

701

Q9BZF3
GWTILLTLTMGQGEP

HCP5

41

Q6MZN7
SLGWTMLVNRFLGPK

MFN2

546

O95140
PSLTLFGGKPMEGWI

MED16

166

Q9Y2X0
GEWAEAMLPTLGKVG

MIB1

356

Q86YT6
WEPSKNTLIMGLGTQ

MIB1

731

Q86YT6
SPKPLLTGLMWAQQG

MOGS

111

Q13724
LKWEMQLPGASQGLT

PAX4

231

O43316
LGRGGLKKSMAWDLP

ARHGAP6

126

O43182
TADWVLPGKKMGNLS

NCOA4

536

Q13772
AMQPWQPLGTKSILG

GAL3ST1

361

Q99999
GSGWLIKGMDQGLLG

FKBP10

206

Q96AY3
RNVTAIQGPGGKWMI

IDH3A

66

P50213
MWKSPNGTIRNILGG

IDH1

91

O75874
MWKSPNGTIRNILGG

IDH2

131

P48735
LPTWGKVGLGLAGTM

IGSF5

261

Q9NSI5
EMVKGLAPLQATVWG

C2CD3

1011

Q4AC94
MALSPWTPGLGAGEK

CCDC175

1

P0C221
EKSWPVMLVGNAGTG

DNAH17

2446

Q9UFH2
WGIMGTVLLTGGLKQ

ELOVL3

86

Q9HB03
LPAGLGSVRSWMQGA

EBF4

21

Q9BQW3
GMVTLTPNKGVWVNG

FCGBP

5301

Q9Y6R7
TGPGKWEGARNAIMT

FMO1

476

Q01740
LLIFSSISWMGGKNP

TMEM30B

301

Q3MIR4
SISWMGGKNPFLGIA

TMEM30B

306

Q3MIR4
MWLKVGGLLRGTGGQ

COQ8B

1

Q96D53
QGFKVWMGPISPLLS

CYP4F2

86

P78329
ILSTISWMGGKNPFL

TMEM30A

311

Q9NV96
SMGPKKVGTLWREAG

EIF4G1

1386

Q04637
WGVNPGMAISGVLLV

MS4A8

176

Q9BY19
GIPWALLNMKSGIGR

MAN1A1

321

P33908
TGIPWAMVNLKSGVG

MAN1A2

306

O60476
PWQSGVLAIGGGMKD

CDC20B

411

Q86Y33
WPSLTLLGGALIVGM

KCNMB3

216

Q9NPA1
DGLALGMGQGLKAWP

KIRREL1

56

Q96J84
ISLGAPWGGSIKPML

LCAT

231

P04180
PWGGSIKPMLVLASG

LCAT

236

P04180
QLLGLLMLWVPGSSG

IGKV2-24

6

A0A0C4DH68
QLLGLLMLWVPGSSG

IGKV2-30

6

P06310
GIWSSGVDMLPNGAV

LINC01560

36

Q8TB33
MAPSLWKGLVGIGLF

MMGT1

1

Q8N4V1
GGKMVAFAGWSLPVQ

AMT

46

P48728
LLIWSPGKGKVMVAA

HPS6

216

Q86YV9
RTGWLVGNTGVLLGM

SLC12A8

61

A0AV02
KMPWNIVLLLGGGYA

SLC13A2

416

Q13183
SKGHIWKLMGLIGGI

SLC39A12

441

Q504Y0
MGTSILSIPWGIKQA

SLC38A9

131

Q8NBW4
MGLGQPQAWLLGLPT

MFSD13A

1

Q14CX5
PGMWERTITIGSAGK

KYAT3

266

Q6YP21
GRGPILPGTKAWMET

PRAP1

81

Q96NZ9
GSMVILSQGQWMGLP

OSGIN1

136

Q9UJX0
ASGRESLKMGIGWKP

PCARE

786

A6NGG8
MVGLPAAGKTTWAIK

HNRNPUL1

426

Q9BUJ2
GTVLGIKNLSDIGWP

MAP3K4

411

Q9Y6R4
MNIKGSPWKGSLLLL

PRL

1

P01236
WKGVLMVGPPGTGKT

KATNAL1

241

Q9BW62
MAGLGLGSAVPVWLA

RNF135

1

Q8IUD6
QTLPVMSGEALGWLG

SOHLH1

251

Q5JUK2
GGLGVWKLAPMFKGV

SLC6A1

111

P30531
FGGGTTPMLTWLQIR

SLC9A9

476

Q8IVB4
GKNMAPLEALVWGVG

TMEM170B

101

Q5T4T1
GGELWGVDIPLKQLM

PIWIL2

726

Q8TC59
MGSHKTQRLLSGPWV

NBEAL2

2441

Q6ZNJ1
SLKLDMNPGTGIWQS

MSTN

191

O14793
KPWAVYAGLLGGVIM

SLAMF1

236

Q13291
LLLPLLWGTKGMEGD

SIGLEC8

6

Q9NYZ4
MTASQGPCALLWKGG

SPATA31E1

1161

Q6ZUB1
GSSGWPTMVLVLPGN

MYCBP2

2101

O75592
KGLSMNWVKGPIAVG

SLC25A42

286

Q86VD7
MLLVRGVTLPGAWKG

SLC6A7

256

Q99884
EMGIGGVLGLLWFQK

ACLY

866

P53396
GQKMPLIGLGTWKSE

AKR1A1

11

P14550
NSVSTGLMRPPWLKG

CHST1

281

O43916
TPLKLIDSWMGKGAA

RECQL

511

P46063
WMVPGSAGLLRLSAG

TCERG1L

41

Q5VWI1
PGLRVTVMLGGSWLQ

PPOX

361

P50336
LTLALLGGPTWAGKM

ZG16B

41

Q96DA0
MAAPKGSLWVRTQLG

TMEM59

1

Q9BXS4
LLITGGLMPSDGSNW

TM2D2

196

Q9BX73
TAVGRTAGWNIPMGL

TF

471

P02787
MGSPGMVLGLLVQIW

TMIGD2

1

Q96BF3
IKNLSGWMGRTGPGF

RNF112

431

Q9ULX5
GLWLGMAKLGVEAAL

SLC27A4

141

Q6P1M0
TSKPMVLFLGPWSVG

SRL

91

Q86TD4
VLFLGPWSVGKSTMI

SRL

96

Q86TD4
PLWKSVIGGMMAGVI

SLC25A27

126

O95847
GLMTGLILKLPLWGQ

RHAG

376

Q02094
SPMGWAGPLALGLLT

TMDD1

211

P0DPE3
PEGSLGWVLPNTAMK

RRAGB

26

Q5VZM2
TSGMLISVLGIWVPG

TMEM171

121

Q8WVE6
SWGEGLVTAQRGMLP

PLEKHH1

281

Q9ULM0
GGTTPMLSWLNIRVG

SLC9A7

526

Q96T83
GAIAKAIGFPWLMTI

SLC18A2

441

Q05940
GSKGMNQVPGRLLLW

WDR91

531

A4D1P6
GTTLGGNVLIWPMEG

UGT2A1

16

P0DTE4
QGKEPWMVSRDVLGG

ZNF850

61

A8MQ14
SMVKLIGITGHGIPW

PLPP7

111

Q8NBV4
TKKVHLWGMCGPLLG

ZNF776

86

Q68DI1
FMKGIGWLPLGSLEA

NEB

1931

P20929