Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	acetylcholine receptor regulator activity	SPDYE1 SPDYE5 SPDYE2B SPDYE6 SPDYE16 SPDYE2	1.57e-12	27	29	6	GO:0030548
GeneOntologyMolecularFunction	neurotransmitter receptor regulator activity	SPDYE1 SPDYE5 SPDYE2B SPDYE6 SPDYE16 SPDYE2	1.99e-12	28	29	6	GO:0099602
GeneOntologyMolecularFunction	protein kinase binding	SPDYE1 SPDYE21 SPDYE5 SPDYE18 SPDYE2B SPDYE6 SPDYE16 SPDYE2	2.44e-05	873	29	8	GO:0019901
GeneOntologyMolecularFunction	kainate selective glutamate receptor activity	GRIK4 GRIK5	3.04e-05	6	29	2	GO:0015277
GeneOntologyMolecularFunction	kinase binding	SPDYE1 SPDYE21 SPDYE5 SPDYE18 SPDYE2B SPDYE6 SPDYE16 SPDYE2	5.15e-05	969	29	8	GO:0019900
GeneOntologyMolecularFunction	signaling receptor regulator activity	SPDYE1 SPDYE5 SPDYE2B SPDYE6 SPDYE16 SPDYE2	2.18e-04	616	29	6	GO:0030545
GeneOntologyMolecularFunction	glutamate-gated receptor activity	GRIK4 GRIK5	2.73e-04	17	29	2	GO:0004970
GeneOntologyMolecularFunction	ligand-gated sodium channel activity	GRIK4 GRIK5	3.07e-04	18	29	2	GO:0015280
GeneOntologyMolecularFunction	ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	GRIK4 GRIK5	5.51e-04	24	29	2	GO:0099507
GeneOntologyMolecularFunction	glutamate receptor activity	GRIK4 GRIK5	6.99e-04	27	29	2	GO:0008066
GeneOntologyMolecularFunction	sodium channel activity	GRIK4 GRIK5	2.58e-03	52	29	2	GO:0005272
GeneOntologyMolecularFunction	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	GRIK4 GRIK5	3.09e-03	57	29	2	GO:1904315
GeneOntologyMolecularFunction	neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential	GRIK4 GRIK5	3.42e-03	60	29	2	GO:0099529
GeneOntologyMolecularFunction	transmitter-gated channel activity	GRIK4 GRIK5	4.00e-03	65	29	2	GO:0022835
GeneOntologyMolecularFunction	transmitter-gated monoatomic ion channel activity	GRIK4 GRIK5	4.00e-03	65	29	2	GO:0022824
GeneOntologyMolecularFunction	postsynaptic neurotransmitter receptor activity	GRIK4 GRIK5	5.29e-03	75	29	2	GO:0098960
GeneOntologyMolecularFunction	extracellular ligand-gated monoatomic ion channel activity	GRIK4 GRIK5	5.57e-03	77	29	2	GO:0005230
GeneOntologyMolecularFunction	organic anion transmembrane transporter activity	GRIK4 GRIK5 SLC37A4	8.62e-03	293	29	3	GO:0008514
GeneOntologyMolecularFunction	neurotransmitter receptor activity	GRIK4 GRIK5	9.23e-03	100	29	2	GO:0030594
GeneOntologyMolecularFunction	amino acid transmembrane transporter activity	GRIK4 GRIK5	1.01e-02	105	29	2	GO:0015171
GeneOntologyBiologicalProcess	positive regulation of cyclin-dependent protein serine/threonine kinase activity	SPDYE1 SPDYE5 SPDYE2B SPDYE6 SPDYE16 SPDYE2	4.82e-13	25	27	6	GO:0045737
GeneOntologyBiologicalProcess	positive regulation of cyclin-dependent protein kinase activity	SPDYE1 SPDYE5 SPDYE2B SPDYE6 SPDYE16 SPDYE2	1.02e-12	28	27	6	GO:1904031
GeneOntologyBiologicalProcess	regulation of cyclin-dependent protein serine/threonine kinase activity	SPDYE1 SPDYE5 SPDYE2B SPDYE6 SPDYE16 SPDYE2	2.37e-09	96	27	6	GO:0000079
GeneOntologyBiologicalProcess	regulation of cyclin-dependent protein kinase activity	SPDYE1 SPDYE5 SPDYE2B SPDYE6 SPDYE16 SPDYE2	3.04e-09	100	27	6	GO:1904029
GeneOntologyBiologicalProcess	positive regulation of protein serine/threonine kinase activity	SPDYE1 SPDYE5 SPDYE2B SPDYE6 SPDYE16 SPDYE2	1.56e-07	193	27	6	GO:0071902
GeneOntologyBiologicalProcess	positive regulation of cell cycle	SPDYE1 SPDYE5 RRM2 SPDYE2B SPDYE6 SPDYE16 SPDYE2	6.99e-07	407	27	7	GO:0045787
GeneOntologyBiologicalProcess	positive regulation of protein kinase activity	SPDYE1 SPDYE5 SPDYE2B SPDYE6 SPDYE16 SPDYE2	5.01e-06	350	27	6	GO:0045860
GeneOntologyBiologicalProcess	regulation of protein serine/threonine kinase activity	SPDYE1 SPDYE5 SPDYE2B SPDYE6 SPDYE16 SPDYE2	5.70e-06	358	27	6	GO:0071900
GeneOntologyBiologicalProcess	positive regulation of kinase activity	SPDYE1 SPDYE5 SPDYE2B SPDYE6 SPDYE16 SPDYE2	1.15e-05	405	27	6	GO:0033674
GeneOntologyBiologicalProcess	positive regulation of transferase activity	SPDYE1 SPDYE5 SPDYE2B SPDYE6 SPDYE16 SPDYE2	3.38e-05	490	27	6	GO:0051347
GeneOntologyBiologicalProcess	regulation of protein kinase activity	SPDYE1 SPDYE5 SPDYE2B SPDYE6 SPDYE16 SPDYE2	1.15e-04	611	27	6	GO:0045859
GeneOntologyBiologicalProcess	regulation of kinase activity	SPDYE1 SPDYE5 SPDYE2B SPDYE6 SPDYE16 SPDYE2	2.16e-04	686	27	6	GO:0043549
GeneOntologyBiologicalProcess	positive regulation of catalytic activity	SPDYE1 SPDYE5 SPDYE2B SLC37A4 SPDYE6 SPDYE16 SPDYE2	2.76e-04	1028	27	7	GO:0043085
GeneOntologyBiologicalProcess	positive regulation of protein phosphorylation	SPDYE1 SPDYE5 SPDYE2B SPDYE6 SPDYE16 SPDYE2	2.88e-04	724	27	6	GO:0001934
GeneOntologyBiologicalProcess	positive regulation of phosphorylation	SPDYE1 SPDYE5 SPDYE2B SPDYE6 SPDYE16 SPDYE2	4.30e-04	780	27	6	GO:0042327
GeneOntologyBiologicalProcess	regulation of transferase activity	SPDYE1 SPDYE5 SPDYE2B SPDYE6 SPDYE16 SPDYE2	5.25e-04	810	27	6	GO:0051338
GeneOntologyBiologicalProcess	ionotropic glutamate receptor signaling pathway	GRIK4 GRIK5	5.68e-04	27	27	2	GO:0035235
GeneOntologyBiologicalProcess	regulation of presynaptic membrane potential	GRIK4 GRIK5	7.99e-04	32	27	2	GO:0099505
GeneOntologyBiologicalProcess	positive regulation of phosphate metabolic process	SPDYE1 SPDYE5 SPDYE2B SPDYE6 SPDYE16 SPDYE2	8.08e-04	879	27	6	GO:0045937
GeneOntologyBiologicalProcess	positive regulation of phosphorus metabolic process	SPDYE1 SPDYE5 SPDYE2B SPDYE6 SPDYE16 SPDYE2	8.08e-04	879	27	6	GO:0010562
GeneOntologyBiologicalProcess	regulation of cell cycle	SPDYE1 SPDYE5 RRM2 SPDYE2B SPDYE6 SPDYE16 SPDYE2	9.22e-04	1256	27	7	GO:0051726
GeneOntologyBiologicalProcess	positive regulation of protein modification process	SPDYE1 SPDYE5 SPDYE2B SPDYE6 SPDYE16 SPDYE2	1.13e-03	937	27	6	GO:0031401
GeneOntologyBiologicalProcess	ligand-gated ion channel signaling pathway	GRIK4 GRIK5	1.25e-03	40	27	2	GO:1990806
GeneOntologyBiologicalProcess	positive regulation of molecular function	SPDYE1 SPDYE5 SPDYE2B SLC37A4 SPDYE6 SPDYE16 SPDYE2	1.97e-03	1430	27	7	GO:0044093
GeneOntologyBiologicalProcess	positive regulation of protein metabolic process	SPDYE1 SPDYE5 SPDYE2B L3MBTL3 SPDYE6 SPDYE16 SPDYE2	2.20e-03	1458	27	7	GO:0051247
GeneOntologyCellularComponent	kainate selective glutamate receptor complex	GRIK4 GRIK5	2.59e-05	6	28	2	GO:0032983
GeneOntologyCellularComponent	sodium channel complex	GRIK4 GRIK5	6.87e-04	29	28	2	GO:0034706
Domain	Spy1	SPDYE1 SPDYE21 SPDYE5 SPDYE2B SPDYE6 SPDYE16 SPDYE2	3.26e-18	11	29	7	PF11357
Domain	Speedy	SPDYE1 SPDYE21 SPDYE5 SPDYE2B SPDYE6 SPDYE16 SPDYE2	3.26e-18	11	29	7	IPR020984
Domain	PBPe	GRIK4 GRIK5	3.51e-04	18	29	2	SM00079
Domain	Iono_rcpt_met	GRIK4 GRIK5	3.51e-04	18	29	2	IPR001508
Domain	Glu/Gly-bd	GRIK4 GRIK5	3.51e-04	18	29	2	IPR019594
Domain	Iontro_rcpt	GRIK4 GRIK5	3.51e-04	18	29	2	IPR001320
Domain	Lig_chan	GRIK4 GRIK5	3.51e-04	18	29	2	PF00060
Domain	Lig_chan-Glu_bd	GRIK4 GRIK5	3.51e-04	18	29	2	SM00918
Domain	Lig_chan-Glu_bd	GRIK4 GRIK5	3.51e-04	18	29	2	PF10613
Domain	ANF_receptor	GRIK4 GRIK5	1.50e-03	37	29	2	PF01094
Domain	ANF_lig-bd_rcpt	GRIK4 GRIK5	1.50e-03	37	29	2	IPR001828
Domain	Peripla_BP_I	GRIK4 GRIK5	1.66e-03	39	29	2	IPR028082
Pathway	REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS	GRIK4 GRIK5	4.10e-05	10	14	2	M10272
Pathway	REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS	GRIK4 GRIK5	6.01e-05	12	14	2	MM15142
Pathway	REACTOME_ACTIVATION_OF_KAINATE_RECEPTORS_UPON_GLUTAMATE_BINDING	GRIK4 GRIK5	3.92e-04	30	14	2	M18193
Pathway	REACTOME_ACTIVATION_OF_KAINATE_RECEPTORS_UPON_GLUTAMATE_BINDING	GRIK4 GRIK5	4.47e-04	32	14	2	MM15143
Pubmed	Murine fertility and spermatogenesis are independent of the testis-specific Spdye4a gene.	SPDYE1 SPDYE5 SPDYE2B SPDYE6 SPDYE16 SPDYE2	2.51e-17	9	31	6	36272447
Pubmed	Identification and comparative analysis of multiple mammalian Speedy/Ringo proteins.	SPDYE1 SPDYE5 SPDYE2B SPDYE6 SPDYE16 SPDYE2	5.12e-16	13	31	6	15611625
Pubmed	Characterization of a new family of cyclin-dependent kinase activators.	SPDYE1 SPDYE5 SPDYE2B SPDYE6 SPDYE16 SPDYE2	3.68e-15	17	31	6	15574121
Pubmed	Genetic ablation of the GluK4 kainate receptor subunit causes anxiolytic and antidepressant-like behavior in mice.	GRIK4 GRIK5	7.69e-07	2	31	2	22203159
Pubmed	High-affinity kainate receptor subunits are necessary for ionotropic but not metabotropic signaling.	GRIK4 GRIK5	7.69e-07	2	31	2	19778510
Pubmed	Subunit-specific desensitization of heteromeric kainate receptors.	GRIK4 GRIK5	7.69e-07	2	31	2	20026616
Pubmed	The DNA sequence of human chromosome 7.	SPDYE21 SPDYE5 SPDYE2B CPED1 SPDYE6 SPDYE16	2.26e-06	441	31	6	12853948
Pubmed	Association study of polymorphisms in the GluR7, KA1 and KA2 kainate receptor genes (GRIK3, GRIK4, GRIK5) with schizophrenia.	GRIK4 GRIK5	2.31e-06	3	31	2	16325263
Pubmed	Evolution of the Cdk-activator Speedy/RINGO in vertebrates.	SPDYE6 SPDYE2	2.31e-06	3	31	2	22763696
Pubmed	Distribution of kainate receptor subunits at hippocampal mossy fiber synapses.	GRIK4 GRIK5	4.61e-06	4	31	2	12954862
Pubmed	Developmental expression patterns of kainate receptors in the mouse spinal cord.	GRIK4 GRIK5	7.68e-06	5	31	2	23076118
Pubmed	Determination of kainate receptor subunit ratios in mouse brain using novel chimeric protein standards.	GRIK4 GRIK5	7.68e-06	5	31	2	26448475
Pubmed	Molecular determinants of kainate receptor trafficking.	GRIK4 GRIK5	7.68e-06	5	31	2	18358623
Pubmed	Biochemical and assembly properties of GluR6 and KA2, two members of the kainate receptor family, determined with subunit-specific antibodies.	GRIK4 GRIK5	7.68e-06	5	31	2	8288598
Pubmed	Kainate receptors: pharmacology, function and therapeutic potential.	GRIK4 GRIK5	7.68e-06	5	31	2	18793656
Pubmed	Development of laminar distributions of kainate receptors in the somatosensory cortex of mice.	GRIK4 GRIK5	7.68e-06	5	31	2	9593973
Pubmed	Complete Disruption of the Kainate Receptor Gene Family Results in Corticostriatal Dysfunction in Mice.	GRIK4 GRIK5	7.68e-06	5	31	2	28228252
Pubmed	Kainate receptor subunits underlying presynaptic regulation of transmitter release in the dorsal horn.	GRIK4 GRIK5	7.68e-06	5	31	2	12223554
Pubmed	Preferential assembly of heteromeric kainate and AMPA receptor amino terminal domains.	GRIK4 GRIK5	7.68e-06	5	31	2	29058671
Pubmed	N-glycan content modulates kainate receptor functional properties.	GRIK4 GRIK5	1.15e-05	6	31	2	28714086
Pubmed	Glutamate binding and conformational flexibility of ligand-binding domains are critical early determinants of efficient kainate receptor biogenesis.	GRIK4 GRIK5	1.61e-05	7	31	2	19342380
Pubmed	Short-term plasticity of kainate receptor-mediated EPSCs induced by NMDA receptors at hippocampal mossy fiber synapses.	GRIK4 GRIK5	1.61e-05	7	31	2	17428973
Pubmed	Association analysis of the glutamic acid decarboxylase 2 and the glutamine synthetase genes (GAD2, GLUL) with schizophrenia.	GRIK4 GRIK5	2.15e-05	8	31	2	19125103
Pubmed	Expression of glutamate receptor subunit genes during development of the mouse retina.	GRIK4 GRIK5	2.76e-05	9	31	2	9051806
Pubmed	The genes encoding the glutamate receptor subunits KA1 and KA2 (GRIK4 and GRIK5) are located on separate chromosomes in human, mouse, and rat.	GRIK4 GRIK5	2.76e-05	9	31	2	7527545
Pubmed	Splicing and editing of ionotropic glutamate receptors: a comprehensive analysis based on human RNA-Seq data.	GRIK4 GRIK5	2.76e-05	9	31	2	34100982
Pubmed	A local Wnt-3a signal is required for development of the mammalian hippocampus.	CNTN3 GRIK4	5.05e-05	12	31	2	10631167
Pubmed	Glutamate can act as a signaling molecule in mouse preimplantation embryos†.	GRIK4 GRIK5	2.10e-04	24	31	2	35746896
Cytoband	Ensembl 112 genes in cytogenetic band chr7q11	SPDYE21 SPDYE5 SPDYE18 SPDYE16	3.30e-05	271	31	4	chr7q11
Cytoband	7q22.1	SPDYE2B SPDYE6 SPDYE2	6.21e-05	113	31	3	7q22.1
Cytoband	Ensembl 112 genes in cytogenetic band chr7q22	SPDYE2B SPDYE6 SPDYE2	4.36e-04	219	31	3	chr7q22
Cytoband	7q11.23	SPDYE5 SPDYE18	1.97e-03	97	31	2	7q11.23
Cytoband	Ensembl 112 genes in cytogenetic band chr5p13	CPLANE1 IL7R	4.00e-03	139	31	2	chr5p13
Cytoband	Ensembl 112 genes in cytogenetic band chr11q23	GRIK4 SLC37A4	9.70e-03	220	31	2	chr11q23
GeneFamily	Speedy/RINGO cell cycle regulator family	SPDYE1 SPDYE5 SPDYE2B SPDYE6 SPDYE2	4.20e-13	12	18	5	756
GeneFamily	Glutamate ionotropic receptor kainate type subunits	GRIK4 GRIK5	9.35e-06	5	18	2	1199
GeneFamily	Fibronectin type III domain containing	CNTN3 IL7R	1.09e-02	160	18	2	555
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Mesenchymal-immature_mesenchymal_cell-Mesoderm_1_(HAND1+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SPDYE1 FAM193B SPDYE5 FLACC1	2.73e-06	146	30	4	40784fd7ef856f64edfb5a054c0c5d95c8150b20
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c10-MKI67-GZMK\|Severe-critical_progression_d12-22 / Compartment, severity and other cell annotations on 10x 3' data (130k)	ZFP28 RRM2 FLACC1 SLC37A4	8.76e-06	196	30	4	de70cc301a8cbaedb0a5ea4a6442dcdaa477822d
Drug	Azone	GRIK4 GRIK5 RRM2	1.87e-06	20	28	3	CID000042981
Drug	2-acetylpyridine	GRIK4 GRIK5 RRM2	5.96e-06	29	28	3	CID000014286
Drug	aminothiazole 6	GRIK4 GRIK5	8.74e-06	4	28	2	CID005329388
Drug	acromelic acid B	GRIK4 GRIK5	8.74e-06	4	28	2	CID000158974
Drug	Brn 1074551	GRIK4 GRIK5	8.74e-06	4	28	2	CID000120220
Drug	4-methyleneglutamic acid	GRIK4 GRIK5	8.74e-06	4	28	2	CID000096407
Drug	diCl-HQC	GRIK4 GRIK5	8.74e-06	4	28	2	CID003018579
Drug	3-hydroxy-2-quinoxalinecarboxylic acid	GRIK4 GRIK5	1.46e-05	5	28	2	CID000071001
Drug	bromowillardiine	GRIK4 GRIK5	1.46e-05	5	28	2	CID000167842
Drug	ipenoxazone	GRIK4 GRIK5	1.46e-05	5	28	2	CID000065882
Drug	pBB-PzDA	GRIK4 GRIK5	1.46e-05	5	28	2	CID000124528
Drug	ethyl propiolate	GRIK4 GRIK5	1.46e-05	5	28	2	CID000012182
Drug	pyrimidine-2,4-dione	GRIK4 GRIK5	1.46e-05	5	28	2	CID000150747
Drug	jatrorrhizine	CNTN3 TOP1	2.18e-05	6	28	2	CID000072323
Drug	3-acetylisoquinoline	GRIK4 GRIK5	2.18e-05	6	28	2	CID000124656
Drug	oxolinic acid	CNTN3 PSD TOP1	2.28e-05	45	28	3	CID000004628
Drug	fluorocyclobutane	GRIK4 GRIK5	3.05e-05	7	28	2	CID011051569
Drug	alclofenac	GRIK4 GRIK5	3.05e-05	7	28	2	CID000030951
Drug	1v79	GRIK4 GRIK5	4.07e-05	8	28	2	CID000449014
Drug	norcyclizine	GRIK4 GRIK5	4.07e-05	8	28	2	CID000070048
Drug	AC1L1B65	GRIK4 GRIK5	4.07e-05	8	28	2	CID000001300
Drug	perzinfotel	GRIK4 GRIK5	4.07e-05	8	28	2	CID006918236
Drug	Ly294486	GRIK4 GRIK5	5.22e-05	9	28	2	CID005311255
Drug	propyl pyrazole triol	GRIK4 GRIK5	5.22e-05	9	28	2	CID006095481
Drug	oxalyl chloride	GRIK4 GRIK5	5.22e-05	9	28	2	CID000065578
Drug	benzo(F)quinoxaline	GRIK4 GRIK5	5.22e-05	9	28	2	CID000098494
Drug	NS3763	GRIK4 GRIK5	5.22e-05	9	28	2	CID004359312
Drug	lithium 3,5-diiodosalicylate	GRIK4 GRIK5	5.22e-05	9	28	2	CID002735070
Drug	LY339434	GRIK4 GRIK5	5.22e-05	9	28	2	CID006324635
Drug	AC1L1CXL	GRIK4 GRIK5	6.52e-05	10	28	2	CID000002106
Drug	1,3-glyceryl dinitrate	GRIK4 GRIK5	6.52e-05	10	28	2	CID000012200
Drug	sym 2206	GRIK4 GRIK5	7.97e-05	11	28	2	CID005039877
Drug	Atpa	GRIK4 GRIK5	9.55e-05	12	28	2	CID000002252
Drug	Span® 80	GRIK4 GRIK5	9.55e-05	12	28	2	CID000347521
Drug	AC1L1K9N	GRIK4 GRIK5	1.13e-04	13	28	2	CID000005398
Drug	dinitroglycerol	GRIK4 GRIK5	1.32e-04	14	28	2	CID000079076
Drug	ACEA-1011	GRIK4 GRIK5	1.52e-04	15	28	2	CID000127872
Drug	TG-1	GRIK4 GRIK5	1.52e-04	15	28	2	CID000060499
Drug	argiopine	GRIK4 GRIK5	1.73e-04	16	28	2	CID000122294
Drug	decahydroisoquinoline	GRIK4 GRIK5	1.73e-04	16	28	2	CID000097812
Drug	K-11	GRIK4 GRIK5	1.96e-04	17	28	2	CID000469667
Drug	3HPG	GRIK4 GRIK5	1.96e-04	17	28	2	CID000001217
Drug	potassiopotassium	GRIK4 GRIK5 TOP1	2.07e-04	94	28	3	CID006432276
Drug	acromelic acid A	GRIK4 GRIK5	2.20e-04	18	28	2	CID000108086
Drug	LY382884	GRIK4 GRIK5	2.46e-04	19	28	2	CID000656723
Drug	IDRA 21	GRIK4 GRIK5	2.73e-04	20	28	2	CID000003688
Drug	AC1N8N2J	GRIK4 GRIK5	2.73e-04	20	28	2	CID004346372
Drug	4-carboxy-3-hydroxyphenylglycine	GRIK4 GRIK5	2.73e-04	20	28	2	CID000001297
Drug	AC1LAED8	GRIK4 GRIK5	3.02e-04	21	28	2	CID000486506
Drug	tren	GRIK4 GRIK5	3.02e-04	21	28	2	CID000077731
Drug	chlorcyclizine	GRIK4 GRIK5	3.02e-04	21	28	2	CID000002710
Drug	CX546	GRIK4 GRIK5	3.02e-04	21	28	2	CID000002890
Drug	AC1L1B62	GRIK4 GRIK5	3.02e-04	21	28	2	CID000001299
Drug	D UN	CNTN3 RRM2	3.32e-04	22	28	2	CID000449098
Drug	NS 102	GRIK4 GRIK5	3.32e-04	22	28	2	CID005282252
Drug	CX516	GRIK4 GRIK5	3.32e-04	22	28	2	CID000148184
Drug	YM90K	GRIK4 GRIK5	3.63e-04	23	28	2	CID005486547
Drug	CGP 39653	GRIK4 GRIK5	3.96e-04	24	28	2	CID006437837
Drug	gavestinel	GRIK4 GRIK5	4.30e-04	25	28	2	CID006450546
Drug	Ns102	GRIK4 GRIK5	4.30e-04	25	28	2	CID005311098
Drug	dFdCTP	RRM2 TOP1	5.02e-04	27	28	2	CID000130659
Drug	L-689,560	GRIK4 GRIK5	5.02e-04	27	28	2	CID000121918
Drug	enzacamene	CNTN3 GRIK4 GRIK5	5.25e-04	129	28	3	ctd:C038939
Drug	aptiganel	GRIK4 GRIK5	5.40e-04	28	28	2	CID000060839
Drug	C-PP	GRIK4 GRIK5	5.40e-04	28	28	2	CID000001228
Drug	AC1NUW3V	GRIK4 GRIK5	5.80e-04	29	28	2	CID005462126
Drug	ketobemidone	GRIK4 GRIK5	5.80e-04	29	28	2	CID000010101
Drug	LY293558	GRIK4 GRIK5	6.21e-04	30	28	2	CID000127894
Drug	AC1L32TU	GRIK4 GRIK5	6.21e-04	30	28	2	CID000107831
Drug	cis-2,3-piperidine dicarboxylic acid	GRIK4 GRIK5	6.21e-04	30	28	2	CID000001226
Drug	GYKI 53655	GRIK4 GRIK5	6.21e-04	30	28	2	CID000126757
Drug	octylmethoxycinnamate	CNTN3 GRIK4 GRIK5	6.52e-04	139	28	3	ctd:C118580
Drug	LY235959	GRIK4 GRIK5	6.63e-04	31	28	2	CID000131938
Drug	4-methylglutamic acid	GRIK4 GRIK5	6.63e-04	31	28	2	CID000005365
Drug	eliprodil	GRIK4 GRIK5	6.63e-04	31	28	2	CID000060703
Drug	NPC 12626	GRIK4 GRIK5	6.63e-04	31	28	2	CID000108099
Drug	willardine	GRIK4 GRIK5	7.07e-04	32	28	2	CID000005123
Drug	alpha-methyl-4-carboxyphenylglycine	GRIK4 GRIK5	7.07e-04	32	28	2	CID000001222
Drug	Depixol	GRIK4 GRIK5	7.52e-04	33	28	2	CID000017011
Drug	TG-3	GRIK4 GRIK5	7.52e-04	33	28	2	CID000205489
Drug	1-aminoindan-1,5-dicarboxylic acid	GRIK4 GRIK5	7.52e-04	33	28	2	CID000002071
Drug	6,7-dinitroquinoxaline	GRIK4 GRIK5	7.52e-04	33	28	2	CID002724608
Drug	D-CPPene	GRIK4 GRIK5	7.99e-04	34	28	2	CID006435801
Drug	CPPG	GRIK4 GRIK5	7.99e-04	34	28	2	CID000002878
Drug	kainite	GRIK4 GRIK5	8.46e-04	35	28	2	CID000164810
Drug	C6H12NO5P	GRIK4 GRIK5	8.95e-04	36	28	2	CID000104962
Drug	glutamic acid diethyl ester	GRIK4 GRIK5	8.95e-04	36	28	2	CID000073960
Drug	gacyclidine	GRIK4 GRIK5	8.95e-04	36	28	2	CID000176265
Drug	R,S)-AMPA	GRIK4 GRIK5	8.95e-04	36	28	2	CID000001221
Drug	butylparaben	CNTN3 GRIK4 GRIK5	9.28e-04	157	28	3	ctd:C038091
Drug	gamma-Glu-Gly	GRIK4 GRIK5	9.46e-04	37	28	2	CID000100099
Drug	2'-azidocytidine	RRM2 TOP1	9.46e-04	37	28	2	CID000093258
Drug	dipicolinic acid	GRIK4 GRIK5	9.46e-04	37	28	2	CID000010367
Drug	GAMs	GRIK4 GRIK5	9.98e-04	38	28	2	CID000002935
Drug	L-BMAA	GRIK4 GRIK5	9.98e-04	38	28	2	CID000028558
Drug	CGS 19755	GRIK4 GRIK5	9.98e-04	38	28	2	CID000068736
Drug	4CPG	GRIK4 GRIK5	9.98e-04	38	28	2	CID000005115
Drug	DETC-MeSO	GRIK4 GRIK5	1.05e-03	39	28	2	CID003035711
Drug	HA-966	GRIK4 GRIK5	1.05e-03	39	28	2	CID000001232
Drug	7-OH-DPAT	GRIK4 GRIK5	1.05e-03	39	28	2	CID000001219
Disease	heart rate response to recovery post exercise	CNTN3 GRIK5	1.07e-03	57	25	2	EFO_0009185
Disease	estrogen-receptor negative breast cancer	L3MBTL3 FLACC1	1.65e-03	71	25	2	EFO_1000650
Disease	body surface area	ADAMTS17 RRM2 CPED1 L3MBTL3	1.96e-03	643	25	4	EFO_0022196
Disease	apolipoprotein B measurement	ZFP28 PSD L3MBTL3 TOP1	2.19e-03	663	25	4	EFO_0004615
Disease	economic and social preference	CNTN3 GRIK5	3.05e-03	97	25	2	EFO_0004827
Disease	neuritic plaque measurement	ADAMTS17 GRIK4 GRIK5	3.11e-03	349	25	3	EFO_0006798

Protein segments in the cluster

Peptide	Gene	Start	Entry
LLKTVKPRVWKPGDW	CPED1	231	A4D0V7
KFTWPAKGRPRKIAW	ANKRD30A	371	Q9BXX3
PNIRKWKGPRGCWKA	EEPD1	321	Q7L9B9
EKKKPTWGRPSRDWR	ADAMTS17	206	Q8TE56
KQGLPPKGKKAWCWA	L3MBTL3	221	Q96JM7
CWDPWNLGPRKLIKT	FLACC1	11	Q96Q35
CVLWKKRIKPIVWPS	IL7R	261	P16871
LGWPPCGKVLRKWFE	SLC37A4	116	O43826
TGIKQKKPWPRVSWL	CPLANE1	11	Q9H799
KKPWPRVSWLGKEKE	CPLANE1	16	Q9H799
PKTEKEKGSSWRNWP	FAM193B	786	Q96PV7
WSFRRLKKLCRPLPW	C17orf80	571	Q9BSJ5
RWEWPGSPKALEKCN	FHIP2A	611	Q5W0V3
LEILKRKWWEGGKCP	GRIK4	776	Q16099
EILKRKWWEGGRCPK	GRIK5	776	Q16478
CKPRASPRALSSWKK	CNTN3	431	Q9P232
CPKKSESLWKGWDRK	MORN3	6	Q6PF18
SGCTFWGKKPWSRKK	RNF19B	331	Q6ZMZ0
PDCRKTPRGKRGWKS	PSD	771	A5PKW4
PPCRSLGWKRKREWS	SPDYE2B	61	A6NHP3
KPESKKSGLLWFWLP	AHNAK2	5636	Q8IVF2
PWTVKRKMTRAWCPD	ZFP28	161	Q8NHY6
PCVKKKADWALRWIG	RRM2	201	P31350
PPCRSLGWKRKKEWS	SPDYE16	21	A6NNV3
PPCRSLGWKRKKEWS	SPDYE18	61	P0DV79
PPCRSLGWKRKKEWS	SPDYE21	61	A0A494C086
PPCRSLGWKRKREWS	SPDYE2	61	Q495Y8
PPCRSLGWKRKREWS	SPDYE5	61	A6NIY4
PPCRSLGWKRKREWS	SPDYE6	61	P0CI01
PPCRSLGWKRKREWS	SPDYE1	21	Q8NFV5
GWLKRFLVWKPRPAS	SAYSD1	46	Q9NPB0
PKPRLSGWTWLKKQL	PRR33	186	A8MZF0
PPCRSLGWKRKKEWS	nan	21	A6NJR5
PRITVAWCKKWGVPI	TOP1	726	P11387