Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	extracellular matrix constituent conferring elasticity	FBN1 FBN2	2.57e-05	12	13	2	GO:0030023
GeneOntologyMolecularFunction	structural molecule activity conferring elasticity	FBN1 FBN2	3.54e-05	14	13	2	GO:0097493
GeneOntologyMolecularFunction	calcium ion binding	LRP2 CABP1 FBN1 FBN2	1.07e-03	749	13	4	GO:0005509
GeneOntologyMolecularFunction	promoter-specific chromatin binding	CHD7 TAF1	1.29e-03	83	13	2	GO:1990841
GeneOntologyMolecularFunction	hormone activity	FBN1 FBN2	3.37e-03	135	13	2	GO:0005179
GeneOntologyMolecularFunction	protein-folding chaperone binding	FNIP2 LRP2	4.75e-03	161	13	2	GO:0051087
GeneOntologyMolecularFunction	molecular function inhibitor activity	FNIP2 CABP1 TAF1	6.05e-03	596	13	3	GO:0140678
GeneOntologyMolecularFunction	nuclear receptor binding	LRP2 TAF1	6.36e-03	187	13	2	GO:0016922
GeneOntologyMolecularFunction	extracellular matrix structural constituent	FBN1 FBN2	6.42e-03	188	13	2	GO:0005201
GeneOntologyBiologicalProcess	sequestering of TGFbeta in extracellular matrix	FBN1 FBN2	2.20e-06	4	13	2	GO:0035583
GeneOntologyBiologicalProcess	maintenance of protein location in extracellular region	FBN1 FBN2	1.02e-05	8	13	2	GO:0071694
GeneOntologyBiologicalProcess	ventricular compact myocardium morphogenesis	LRP2 CHD7	1.32e-05	9	13	2	GO:0003223
GeneOntologyBiologicalProcess	sequestering of extracellular ligand from receptor	FBN1 FBN2	2.01e-05	11	13	2	GO:0035581
GeneOntologyBiologicalProcess	extracellular regulation of signal transduction	FBN1 FBN2	2.85e-05	13	13	2	GO:1900115
GeneOntologyBiologicalProcess	extracellular negative regulation of signal transduction	FBN1 FBN2	2.85e-05	13	13	2	GO:1900116
GeneOntologyBiologicalProcess	female genitalia development	LRP2 CHD7	6.92e-05	20	13	2	GO:0030540
GeneOntologyBiologicalProcess	transforming growth factor beta receptor superfamily signaling pathway	LRP2 FBN1 FBN2 USP9Y	1.31e-04	445	13	4	GO:0141091
GeneOntologyBiologicalProcess	cell surface receptor protein serine/threonine kinase signaling pathway	LRP2 FBN1 FBN2 USP9Y	1.78e-04	482	13	4	GO:0007178
GeneOntologyBiologicalProcess	BMP signaling pathway	LRP2 FBN1 USP9Y	2.29e-04	197	13	3	GO:0030509
GeneOntologyBiologicalProcess	response to BMP	LRP2 FBN1 USP9Y	2.96e-04	215	13	3	GO:0071772
GeneOntologyBiologicalProcess	cellular response to BMP stimulus	LRP2 FBN1 USP9Y	2.96e-04	215	13	3	GO:0071773
GeneOntologyBiologicalProcess	negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway	LRP2 FBN1 FBN2	3.08e-04	218	13	3	GO:0090101
GeneOntologyBiologicalProcess	genitalia development	LRP2 CHD7	5.15e-04	54	13	2	GO:0048806
GeneOntologyBiologicalProcess	trabecula morphogenesis	CHD7 FBN2	5.74e-04	57	13	2	GO:0061383
GeneOntologyBiologicalProcess	transforming growth factor beta receptor signaling pathway	FBN1 FBN2 USP9Y	6.14e-04	276	13	3	GO:0007179
GeneOntologyBiologicalProcess	ventricular cardiac muscle tissue morphogenesis	LRP2 CHD7	6.15e-04	59	13	2	GO:0055010
GeneOntologyBiologicalProcess	ventricular cardiac muscle tissue development	LRP2 CHD7	1.02e-03	76	13	2	GO:0003229
GeneOntologyBiologicalProcess	cardiac muscle tissue morphogenesis	LRP2 CHD7	1.04e-03	77	13	2	GO:0055008
GeneOntologyBiologicalProcess	cellular response to transforming growth factor beta stimulus	FBN1 FBN2 USP9Y	1.09e-03	336	13	3	GO:0071560
GeneOntologyBiologicalProcess	negative regulation of BMP signaling pathway	LRP2 FBN1	1.13e-03	80	13	2	GO:0030514
GeneOntologyBiologicalProcess	aorta development	LRP2 CHD7	1.13e-03	80	13	2	GO:0035904
GeneOntologyBiologicalProcess	response to transforming growth factor beta	FBN1 FBN2 USP9Y	1.15e-03	343	13	3	GO:0071559
GeneOntologyBiologicalProcess	regulation of transmembrane receptor protein serine/threonine kinase signaling pathway	LRP2 FBN1 FBN2	1.19e-03	347	13	3	GO:0090092
GeneOntologyBiologicalProcess	cardiac ventricle morphogenesis	LRP2 CHD7	1.36e-03	88	13	2	GO:0003208
GeneOntologyBiologicalProcess	cardiac septum morphogenesis	LRP2 CHD7	1.39e-03	89	13	2	GO:0060411
GeneOntologyBiologicalProcess	artery morphogenesis	LRP2 CHD7	1.49e-03	92	13	2	GO:0048844
GeneOntologyBiologicalProcess	muscle tissue morphogenesis	LRP2 CHD7	1.52e-03	93	13	2	GO:0060415
GeneOntologyBiologicalProcess	cellular response to growth factor stimulus	LRP2 FBN1 FBN2 USP9Y	1.52e-03	850	13	4	GO:0071363
GeneOntologyBiologicalProcess	brain development	LRP2 CHD7 TAF1 TBC1D23	1.58e-03	859	13	4	GO:0007420
GeneOntologyBiologicalProcess	maintenance of location	CHD7 FBN1 FBN2	1.74e-03	396	13	3	GO:0051235
GeneOntologyBiologicalProcess	response to growth factor	LRP2 FBN1 FBN2 USP9Y	1.75e-03	883	13	4	GO:0070848
GeneOntologyBiologicalProcess	muscle organ morphogenesis	LRP2 CHD7	1.82e-03	102	13	2	GO:0048644
GeneOntologyBiologicalProcess	regulation of cellular response to growth factor stimulus	LRP2 FBN1 FBN2	1.95e-03	412	13	3	GO:0090287
GeneOntologyBiologicalProcess	head development	LRP2 CHD7 TAF1 TBC1D23	2.03e-03	919	13	4	GO:0060322
GeneOntologyBiologicalProcess	amide transport	LRP2 CHD7 FBN1	2.06e-03	420	13	3	GO:0042886
GeneOntologyBiologicalProcess	maintenance of protein location	FBN1 FBN2	2.19e-03	112	13	2	GO:0045185
GeneOntologyBiologicalProcess	regulation of BMP signaling pathway	LRP2 FBN1	2.98e-03	131	13	2	GO:0030510
GeneOntologyBiologicalProcess	artery development	LRP2 CHD7	3.07e-03	133	13	2	GO:0060840
GeneOntologyBiologicalProcess	cardiac septum development	LRP2 CHD7	3.12e-03	134	13	2	GO:0003279
GeneOntologyBiologicalProcess	negative regulation of transforming growth factor beta receptor signaling pathway	FBN1 FBN2	3.30e-03	138	13	2	GO:0030512
GeneOntologyBiologicalProcess	embryonic limb morphogenesis	CHD7 FBN2	3.79e-03	148	13	2	GO:0030326
GeneOntologyBiologicalProcess	embryonic appendage morphogenesis	CHD7 FBN2	3.79e-03	148	13	2	GO:0035113
GeneOntologyBiologicalProcess	negative regulation of cellular response to growth factor stimulus	LRP2 FBN1	3.89e-03	150	13	2	GO:0090288
GeneOntologyBiologicalProcess	negative regulation of protein transport	CABP1 FBN1	4.04e-03	153	13	2	GO:0051224
GeneOntologyBiologicalProcess	female sex differentiation	LRP2 CHD7	4.25e-03	157	13	2	GO:0046660
GeneOntologyBiologicalProcess	cardiac chamber morphogenesis	LRP2 CHD7	4.46e-03	161	13	2	GO:0003206
GeneOntologyBiologicalProcess	cardiac ventricle development	LRP2 CHD7	4.46e-03	161	13	2	GO:0003231
GeneOntologyBiologicalProcess	regulation of protein transport	LRP2 CABP1 FBN1	4.65e-03	560	13	3	GO:0051223
GeneOntologyBiologicalProcess	negative regulation of establishment of protein localization	CABP1 FBN1	5.02e-03	171	13	2	GO:1904950
GeneOntologyBiologicalProcess	enzyme-linked receptor protein signaling pathway	LRP2 FBN1 FBN2 USP9Y	5.12e-03	1186	13	4	GO:0007167
GeneOntologyBiologicalProcess	central nervous system development	LRP2 CHD7 TAF1 TBC1D23	5.29e-03	1197	13	4	GO:0007417
GeneOntologyBiologicalProcess	appendage morphogenesis	CHD7 FBN2	5.85e-03	185	13	2	GO:0035107
GeneOntologyBiologicalProcess	limb morphogenesis	CHD7 FBN2	5.85e-03	185	13	2	GO:0035108
GeneOntologyBiologicalProcess	skeletal system development	CHD7 FBN1 FBN2	6.03e-03	615	13	3	GO:0001501
GeneOntologyBiologicalProcess	regulation of transforming growth factor beta receptor signaling pathway	FBN1 FBN2	6.28e-03	192	13	2	GO:0017015
GeneOntologyBiologicalProcess	regulation of cellular response to transforming growth factor beta stimulus	FBN1 FBN2	6.48e-03	195	13	2	GO:1903844
GeneOntologyBiologicalProcess	sensory perception of sound	LRP2 CHD7	6.67e-03	198	13	2	GO:0007605
GeneOntologyCellularComponent	microfibril	FBN1 FBN2	2.77e-05	13	13	2	GO:0001527
HumanPheno	Abnormal upper to lower segment ratio	FBN1 FBN2	6.47e-06	3	8	2	HP:0012772
HumanPheno	Crumpled ear	FBN1 FBN2	3.23e-05	6	8	2	HP:0009901
HumanPheno	Osteopenia	CHD7 TAF1 FBN1 FBN2 NAGA	4.61e-05	321	8	5	HP:0000938
HumanPheno	Abnormality of the helix	CHD7 TAF1 FBN1 FBN2	1.01e-04	183	8	4	HP:0000380
HumanPheno	Abnormal helix morphology	CHD7 TAF1 FBN1 FBN2	1.79e-04	212	8	4	HP:0011039
MousePheno	abnormal cerebellum fissure morphology	LRP2 CHD7	1.32e-05	9	9	2	MP:0009267
MousePheno	absent olfactory bulb	LRP2 CHD7	4.99e-05	17	9	2	MP:0003451
MousePheno	abnormal thoracic aorta morphology	LRP2 CHD7 FBN1	6.94e-05	134	9	3	MP:0010468
MousePheno	abnormal digit development	CHD7 FBN2	9.26e-05	23	9	2	MP:0006280
MousePheno	overexpanded pulmonary alveolus	LRP2 FBN1	2.43e-04	37	9	2	MP:0001183
MousePheno	emphysema	LRP2 FBN1	2.43e-04	37	9	2	MP:0001958
MousePheno	abnormal susceptibility to hearing loss	LRP2 CHD7	2.56e-04	38	9	2	MP:0006334
MousePheno	heart right ventricle hypertrophy	LRP2 FBN1	3.13e-04	42	9	2	MP:0000276
MousePheno	abnormal aorta morphology	LRP2 CHD7 FBN1	3.22e-04	225	9	3	MP:0000272
MousePheno	decreased body fat mass	CHD7 FBN1	3.76e-04	46	9	2	MP:0014143
MousePheno	abnormal heart right ventricle wall morphology	LRP2 FBN1	4.81e-04	52	9	2	MP:0031534
MousePheno	small olfactory bulb	LRP2 CHD7	4.99e-04	53	9	2	MP:0002741
MousePheno	increased heart right ventricle size	LRP2 FBN1	5.38e-04	55	9	2	MP:0010563
MousePheno	abnormal systemic artery morphology	LRP2 CHD7 FBN1	7.76e-04	304	9	3	MP:0011655
MousePheno	micrognathia	LRP2 FBN2	8.21e-04	68	9	2	MP:0002639
MousePheno	abnormal phalanx morphology	FBN1 FBN2	1.02e-03	76	9	2	MP:0005306
MousePheno	abnormal heart right ventricle size	LRP2 FBN1	1.08e-03	78	9	2	MP:0010577
MousePheno	abnormal cranium morphology	LRP2 CHD7 FBN1 FBN2	1.13e-03	813	9	4	MP:0000438
MousePheno	abnormal radius morphology	FBN1 FBN2	1.19e-03	82	9	2	MP:0000552
MousePheno	abnormal body fat mass	CHD7 FBN1	1.19e-03	82	9	2	MP:0012320
MousePheno	abnormal craniofacial bone morphology	LRP2 CHD7 FBN1 FBN2	1.21e-03	827	9	4	MP:0002116
MousePheno	abnormal ulna morphology	FBN1 FBN2	1.25e-03	84	9	2	MP:0005108
MousePheno	abnormal pelvic girdle bone morphology	FBN1 FBN2	1.34e-03	87	9	2	MP:0004509
MousePheno	abnormal cranium size	CHD7 FBN1	1.66e-03	97	9	2	MP:0010031
MousePheno	abnormal forelimb zeugopod morphology	FBN1 FBN2	1.84e-03	102	9	2	MP:0003855
MousePheno	abnormal uterus morphology	LRP2 CHD7 FBN1	1.91e-03	415	9	3	MP:0001120
MousePheno	abnormal embryonic neuroepithelium morphology	LRP2 CHD7	1.94e-03	105	9	2	MP:0004261
MousePheno	abnormal artery morphology	LRP2 CHD7 FBN1	2.26e-03	440	9	3	MP:0002191
MousePheno	abnormal circulating mineral level	FNIP2 LRP2 CHD7 DEUP1	2.29e-03	982	9	4	MP:0006357
MousePheno	abnormal lumbar vertebrae morphology	CHD7 FBN1	2.49e-03	119	9	2	MP:0003049
MousePheno	abnormal aortic arch morphology	LRP2 CHD7	2.49e-03	119	9	2	MP:0004113
Domain	cEGF	LRP2 FBN1 FBN2	6.79e-07	26	13	3	PF12662
Domain	cEGF	LRP2 FBN1 FBN2	6.79e-07	26	13	3	IPR026823
Domain	FBN	FBN1 FBN2	1.34e-06	3	13	2	IPR011398
Domain	TB	FBN1 FBN2	9.37e-06	7	13	2	PF00683
Domain	-	FBN1 FBN2	1.25e-05	8	13	2	3.90.290.10
Domain	TB_dom	FBN1 FBN2	1.61e-05	9	13	2	IPR017878
Domain	TB	FBN1 FBN2	1.61e-05	9	13	2	PS51364
Domain	EGF_CA	LRP2 FBN1 FBN2	2.61e-05	86	13	3	PF07645
Domain	EGF_Ca-bd_CS	LRP2 FBN1 FBN2	3.74e-05	97	13	3	IPR018097
Domain	EGF_CA	LRP2 FBN1 FBN2	3.98e-05	99	13	3	PS01187
Domain	ASX_HYDROXYL	LRP2 FBN1 FBN2	4.10e-05	100	13	3	PS00010
Domain	EGF-type_Asp/Asn_hydroxyl_site	LRP2 FBN1 FBN2	4.88e-05	106	13	3	IPR000152
Domain	EGF_CA	LRP2 FBN1 FBN2	7.41e-05	122	13	3	SM00179
Domain	EGF-like_Ca-bd_dom	LRP2 FBN1 FBN2	7.78e-05	124	13	3	IPR001881
Domain	Growth_fac_rcpt_	LRP2 FBN1 FBN2	1.54e-04	156	13	3	IPR009030
Domain	EGF	LRP2 FBN1 FBN2	5.12e-04	235	13	3	SM00181
Domain	EGF_3	LRP2 FBN1 FBN2	5.12e-04	235	13	3	PS50026
Domain	EGF-like_dom	LRP2 FBN1 FBN2	6.07e-04	249	13	3	IPR000742
Domain	EGF_1	LRP2 FBN1 FBN2	6.50e-04	255	13	3	PS00022
Domain	EGF-like_CS	LRP2 FBN1 FBN2	6.96e-04	261	13	3	IPR013032
Domain	EGF_2	LRP2 FBN1 FBN2	7.27e-04	265	13	3	PS01186
Pathway	WP_HYPOTHESIZED_PATHWAYS_IN_PATHOGENESIS_OF_CARDIOVASCULAR_DISEASE	FBN1 FBN2	8.40e-05	25	8	2	M39713
Pathway	REACTOME_MOLECULES_ASSOCIATED_WITH_ELASTIC_FIBRES	FBN1 FBN2	1.39e-04	32	8	2	MM14854
Pathway	REACTOME_MOLECULES_ASSOCIATED_WITH_ELASTIC_FIBRES	FBN1 FBN2	1.86e-04	37	8	2	M27134
Pathway	REACTOME_ELASTIC_FIBRE_FORMATION	FBN1 FBN2	2.07e-04	39	8	2	MM14601
Pathway	REACTOME_ELASTIC_FIBRE_FORMATION	FBN1 FBN2	2.63e-04	44	8	2	M26969
Pathway	REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX	FBN1 FBN2	1.76e-03	114	8	2	MM14571
Pathway	REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX	FBN1 FBN2	2.64e-03	140	8	2	M587
Pubmed	Homo- and heterotypic fibrillin-1 and -2 interactions constitute the basis for the assembly of microfibrils.	FBN1 FBN2	1.29e-07	2	13	2	12399449
Pubmed	Fibrillin-1 and fibrillin-2 are essential for formation of thick oxytalan fibers in human nonpigmented ciliary epithelial cells in vitro.	FBN1 FBN2	1.29e-07	2	13	2	21851253
Pubmed	Fibrillin-1 mutations causing Weill-Marchesani syndrome and acromicric and geleophysic dysplasias disrupt heparan sulfate interactions.	FBN1 FBN2	1.29e-07	2	13	2	23133647
Pubmed	Fibrillins can co-assemble in fibrils, but fibrillin fibril composition displays cell-specific differences.	FBN1 FBN2	1.29e-07	2	13	2	12429739
Pubmed	Fibrillln mutations in Marfan syndrome and related phenotypes.	FBN1 FBN2	1.29e-07	2	13	2	8791520
Pubmed	Rare variants in FBN1 and FBN2 are associated with severe adolescent idiopathic scoliosis.	FBN1 FBN2	1.29e-07	2	13	2	24833718
Pubmed	New Evidence Supporting the Role of FBN1 in the Development of Adolescent Idiopathic Scoliosis.	FBN1 FBN2	1.29e-07	2	13	2	30044367
Pubmed	Material and mechanical properties of bones deficient for fibrillin-1 or fibrillin-2 microfibrils.	FBN1 FBN2	1.29e-07	2	13	2	21440062
Pubmed	Structure and expression of fibrillin-2, a novel microfibrillar component preferentially located in elastic matrices.	FBN1 FBN2	1.29e-07	2	13	2	8120105
Pubmed	The fibrillinopathies: New insights with focus on the paradigm of opposing phenotypes for both FBN1 and FBN2.	FBN1 FBN2	1.29e-07	2	13	2	35419902
Pubmed	MAGP-2 has multiple binding regions on fibrillins and has covalent periodic association with fibrillin-containing microfibrils.	FBN1 FBN2	1.29e-07	2	13	2	15131124
Pubmed	Fibrillin genes map to regions of conserved mouse/human synteny on mouse chromosomes 2 and 18.	FBN1 FBN2	1.29e-07	2	13	2	8307578
Pubmed	Fibrillins 1 and 2 perform partially overlapping functions during aortic development.	FBN1 FBN2	1.29e-07	2	13	2	16407178
Pubmed	Fibrillin assembly: dimer formation mediated by amino-terminal sequences.	FBN1 FBN2	1.29e-07	2	13	2	10504303
Pubmed	Linkage of Marfan syndrome and a phenotypically related disorder to two different fibrillin genes.	FBN1 FBN2	1.29e-07	2	13	2	1852206
Pubmed	N-terminal domains of fibrillin 1 and fibrillin 2 direct the formation of homodimers: a possible first step in microfibril assembly.	FBN1 FBN2	1.29e-07	2	13	2	10359653
Pubmed	Developmental expression of fibrillin genes suggests heterogeneity of extracellular microfibrils.	FBN1 FBN2	1.29e-07	2	13	2	7744963
Pubmed	Nonselective assembly of fibrillin 1 and fibrillin 2 in the rodent ocular zonule and in cultured cells: implications for Marfan syndrome.	FBN1 FBN2	1.29e-07	2	13	2	24265020
Pubmed	Fibrillin-1 and fibrillin-2 in human embryonic and early fetal development.	FBN1 FBN2	1.29e-07	2	13	2	12524050
Pubmed	In vivo studies of mutant fibrillin-1 microfibrils.	FBN1 FBN2	1.29e-07	2	13	2	20529844
Pubmed	Immunohistochemical expression of fibrillin-1 and fibrillin-2 during tooth development.	FBN1 FBN2	1.29e-07	2	13	2	25524144
Pubmed	Fibrillin microfibrils in bone physiology.	FBN1 FBN2	1.29e-07	2	13	2	26408953
Pubmed	Microfibril structure masks fibrillin-2 in postnatal tissues.	FBN1 FBN2	1.29e-07	2	13	2	20404337
Pubmed	Arg-Gly-Asp-containing domains of fibrillins-1 and -2 distinctly regulate lung fibroblast migration.	FBN1 FBN2	1.29e-07	2	13	2	18006876
Pubmed	Interaction of tropoelastin with the amino-terminal domains of fibrillin-1 and fibrillin-2 suggests a role for the fibrillins in elastic fiber assembly.	FBN1 FBN2	3.87e-07	3	13	2	10825173
Pubmed	Adamts10 inactivation in mice leads to persistence of ocular microfibrils subsequent to reduced fibrillin-2 cleavage.	FBN1 FBN2	3.87e-07	3	13	2	30201140
Pubmed	Fibrillin-1 and -2 differentially modulate endogenous TGF-β and BMP bioavailability during bone formation.	FBN1 FBN2	3.87e-07	3	13	2	20855508
Pubmed	Congenital Diaphragmatic Hernia Overview	LRP2 CHD7 FBN1	6.14e-07	46	13	3	20301533
Pubmed	Latent transforming growth factor beta-binding protein 1 interacts with fibrillin and is a microfibril-associated protein.	FBN1 FBN2	7.74e-07	4	13	2	12429738
Pubmed	Comprehensive genetic analysis of relevant four genes in 49 patients with Marfan syndrome or Marfan-related phenotypes.	FBN1 FBN2	7.74e-07	4	13	2	16835936
Pubmed	Human eye development is characterized by coordinated expression of fibrillin isoforms.	FBN1 FBN2	7.74e-07	4	13	2	25406291
Pubmed	Extracellular microfibrils control osteoblast-supported osteoclastogenesis by restricting TGF{beta} stimulation of RANKL production.	FBN1 FBN2	7.74e-07	4	13	2	20729550
Pubmed	Heparin/heparan sulfate controls fibrillin-1, -2 and -3 self-interactions in microfibril assembly.	FBN1 FBN2	7.74e-07	4	13	2	25034023
Pubmed	Characterization of Microfibrillar-associated Protein 4 (MFAP4) as a Tropoelastin- and Fibrillin-binding Protein Involved in Elastic Fiber Formation.	FBN1 FBN2	1.29e-06	5	13	2	26601954
Pubmed	Relaxin regulates fibrillin 2, but not fibrillin 1, mRNA and protein expression by human dermal fibroblasts and murine fetal skin.	FBN1 FBN2	1.29e-06	5	13	2	12590922
Pubmed	Fibrillin-1 interactions with fibulins depend on the first hybrid domain and provide an adaptor function to tropoelastin.	FBN1 FBN2	1.29e-06	5	13	2	17255108
Pubmed	Development, composition, and structural arrangements of the ciliary zonule of the mouse.	FBN1 FBN2	1.29e-06	5	13	2	23493297
Pubmed	POGLUT2 and POGLUT3 O-glucosylate multiple EGF repeats in fibrillin-1, -2, and LTBP1 and promote secretion of fibrillin-1.	FBN1 FBN2	1.29e-06	5	13	2	34411563
Pubmed	Of mice and Marfan: genetic linkage analyses of the fibrillin genes, Fbn1 and Fbn2, in the mouse genome.	FBN1 FBN2	1.93e-06	6	13	2	7873879
Pubmed	Local anesthetics impair the growth and self-renewal of glioblastoma stem cells by inhibiting ZDHHC15-mediated GP130 palmitoylation.	LRP2 FBN1 FBN2	2.30e-06	71	13	3	33541421
Pubmed	Regulation of limb patterning by extracellular microfibrils.	FBN1 FBN2	2.71e-06	7	13	2	11470817
Pubmed	Putative functions of extracellular matrix glycoproteins in secondary palate morphogenesis.	FBN1 FBN2	3.61e-06	8	13	2	23055981
Pubmed	Adamts17 is involved in skeletogenesis through modulation of BMP-Smad1/5/8 pathway.	FBN1 FBN2	3.61e-06	8	13	2	31201465
Pubmed	Targeting of bone morphogenetic protein growth factor complexes to fibrillin.	FBN1 FBN2	3.61e-06	8	13	2	18339631
Pubmed	Microfibril-associated glycoprotein-2 interacts with fibrillin-1 and fibrillin-2 suggesting a role for MAGP-2 in elastic fiber assembly.	FBN1 FBN2	4.64e-06	9	13	2	12122015
Pubmed	Poglut2/3 double knockout in mice results in neonatal lethality with reduced levels of fibrillin in lung tissues.	FBN1 FBN2	4.64e-06	9	13	2	38844137
Pubmed	Limb- and tendon-specific Adamtsl2 deletion identifies a role for ADAMTSL2 in tendon growth in a mouse model for geleophysic dysplasia.	FBN1 FBN2	5.79e-06	10	13	2	30738849
Pubmed	Human transcription factor protein interaction networks.	LRP2 CHD7 TAF1 FBN1 FBN2 GPATCH8	6.37e-06	1429	13	6	35140242
Pubmed	Disruption of murine Adamtsl4 results in zonular fiber detachment from the lens and in retinal pigment epithelium dedifferentiation.	FBN1 FBN2	8.49e-06	12	13	2	26405179
Pubmed	A distinct transcriptome characterizes neural crest-derived cells at the migratory wavefront during enteric nervous system development.	FBN1 FBN2	8.49e-06	12	13	2	36779913
Pubmed	ADAMTS18-fibronectin interaction regulates the morphology of liver sinusoidal endothelial cells.	FBN1 FBN2	1.97e-05	18	13	2	39040056
Pubmed	Proteolysis of fibrillin-2 microfibrils is essential for normal skeletal development.	FBN1 FBN2	1.97e-05	18	13	2	35503090
Pubmed	Adamts18 modulates the development of the aortic arch and common carotid artery.	FBN1 FBN2	4.17e-05	26	13	2	34189436
Pubmed	ADAMTS18 Deficiency Leads to Pulmonary Hypoplasia and Bronchial Microfibril Accumulation.	FBN1 FBN2	5.58e-05	30	13	2	32882513
Pubmed	Heritable Thoracic Aortic Disease Overview	FBN1 FBN2	5.58e-05	30	13	2	20301299
Pubmed	Adamtsl2 deletion results in bronchial fibrillin microfibril accumulation and bronchial epithelial dysplasia--a novel mouse model providing insights into geleophysic dysplasia.	FBN1 FBN2	5.96e-05	31	13	2	25762570
Pubmed	Genome-wide association study of lung function decline in adults with and without asthma.	CHD7 DEUP1	6.36e-05	32	13	2	22424883
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	LRP2 TAF1 FBN1 TBC1D23 USP9Y	6.86e-05	1285	13	5	35914814
Pubmed	O-fucosylation of thrombospondin type 1 repeats is essential for ECM remodeling and signaling during bone development.	FBN1 FBN2	8.07e-05	36	13	2	35167946
Pubmed	Adamts18 Deficiency Causes Spontaneous SMG Fibrogenesis in Adult Mice.	FBN1 FBN2	8.53e-05	37	13	2	34323105
Pubmed	Fibrillin-2 is a key mediator of smooth muscle extracellular matrix homeostasis during mouse tracheal tubulogenesis.	FBN1 FBN2	9.98e-05	40	13	2	30578393
Pubmed	Comparative proteomic analysis of supportive and unsupportive extracellular matrix substrates for human embryonic stem cell maintenance.	FBN1 FBN2	1.56e-04	50	13	2	23658023
Pubmed	Myh10 deficiency leads to defective extracellular matrix remodeling and pulmonary disease.	FBN1 FBN2	1.69e-04	52	13	2	30389913
Pubmed	Targeted Disruption of Mouse Dip2B Leads to Abnormal Lung Development and Prenatal Lethality.	DEUP1 FBN2	1.76e-04	53	13	2	33153107
Interaction	NTN5 interactions	LRP2 FBN1 FBN2	4.21e-07	24	13	3	int:NTN5
Interaction	ZFP41 interactions	LRP2 FBN1 FBN2	6.01e-06	57	13	3	int:ZFP41
Interaction	MFAP2 interactions	FBN1 FBN2	2.53e-05	12	13	2	int:MFAP2
Interaction	ZDHHC15 interactions	LRP2 FBN1 FBN2	6.37e-05	125	13	3	int:ZDHHC15
Interaction	ZNF224 interactions	LRP2 FBN2	7.25e-05	20	13	2	int:ZNF224
Interaction	DEFB125 interactions	LRP2 FBN2	7.25e-05	20	13	2	int:DEFB125
Interaction	WDR76 interactions	CHD7 TAF1 FBN1 FBN2	8.02e-05	383	13	4	int:WDR76
Interaction	ZNF408 interactions	LRP2 FBN1 FBN2	9.90e-05	145	13	3	int:ZNF408
Interaction	TNFAIP6 interactions	LRP2 TBC1D23	1.34e-04	27	13	2	int:TNFAIP6
Interaction	ELN interactions	FBN1 FBN2	1.54e-04	29	13	2	int:ELN
Interaction	GREM2 interactions	LRP2 FBN2	2.53e-04	37	13	2	int:GREM2
Interaction	FEV interactions	CHD7 TAF1 GPATCH8	2.67e-04	203	13	3	int:FEV
Interaction	FBN1 interactions	FBN1 FBN2	4.81e-04	51	13	2	int:FBN1
Interaction	MFAP5 interactions	FBN1 FBN2	5.00e-04	52	13	2	int:MFAP5
Interaction	ANKRD36B interactions	LRP2 CHD7	6.66e-04	60	13	2	int:ANKRD36B
Interaction	HRG interactions	FBN1 FBN2	7.34e-04	63	13	2	int:HRG
Interaction	FBN2 interactions	FBN1 FBN2	7.81e-04	65	13	2	int:FBN2
Interaction	VSX1 interactions	CHD7 USP9Y	8.05e-04	66	13	2	int:VSX1
Interaction	SP7 interactions	CHD7 FBN2 GPATCH8	8.69e-04	304	13	3	int:SP7
Interaction	IGFL3 interactions	LRP2 FBN2	1.04e-03	75	13	2	int:IGFL3
ToppCell	368C-Myeloid-Monocyte-CD16+_Monocyte\|368C / Donor, Lineage, Cell class and subclass (all cells)	LRP2 FBN2 USP9Y	1.14e-05	156	13	3	25b0936960be4955b6a6d6b8a867fdd4be548f05
ToppCell	droplet-Pancreas-Exocrine-18m-Mesenchymal-pancreatic_stellate_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRP2 FBN1 FBN2	1.96e-05	187	13	3	4e553721fa5598cb211f44e3226280b7e6885484
ToppCell	droplet-Pancreas-Exocrine-18m-Mesenchymal\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRP2 FBN1 FBN2	1.96e-05	187	13	3	d36e7fc6125e7a4310499365022d38f34b757a73
ToppCell	droplet-Pancreas-Exocrine-18m-Mesenchymal-pancreatic_stellate_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRP2 FBN1 FBN2	1.96e-05	187	13	3	827eae63fabf6892a82ce7779b5f395958d3d628
ToppCell	Hippocampus-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Calb2-Excitatory_Neuron.Slc17a7.Calb2-Vgll3_(Dentate_hilum?)\|Hippocampus / BrainAtlas - Mouse McCarroll V32	LRP2 USP9Y	1.35e-04	60	13	2	aa75fef294803ec6396c7d2c1f51d52bc4a5b43f
ToppCell	Hippocampus-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Calb2-Excitatory_Neuron.Slc17a7.Calb2-Vgll3_(Dentate_hilum?)-\|Hippocampus / BrainAtlas - Mouse McCarroll V32	LRP2 USP9Y	1.35e-04	60	13	2	069fbabfd0e48e5809ff01a026439fd0bd017779
ToppCell	(02)_Cycling_Basal_(regeneration)-(3)_72hpi\|(02)_Cycling_Basal_(regeneration) / shred by cell type and Timepoint	DEUP1 FBN1	6.62e-04	133	13	2	32c6a00671af309c4b0b90e93549733729684c61
ToppCell	BAL-Mild-Myeloid-MoAM-MoAM2\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	FNIP2 FBN2	8.74e-04	153	13	2	decc4f3098a9374a6b65c015a9d36380986290bf
ToppCell	BAL-Mild-Myeloid-MoAM-MoAM2\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	FNIP2 FBN2	8.74e-04	153	13	2	5fbb90b8477f9fdabf3be19efd3068fbf70abee6
ToppCell	BAL-Mild-Myeloid-MoAM-MoAM2-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	FNIP2 FBN2	8.74e-04	153	13	2	36a28805c0545c2f410c74a6ca0a70d840e75715
ToppCell	BAL-Mild-Myeloid-MoAM-MoAM2-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	FNIP2 FBN2	8.74e-04	153	13	2	2c46183481e6d5a7fa190a743062509465f88e56
ToppCell	facs-Trachea-24m-Hematologic-myeloid-granulocyte-granulocyte_l8\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CHD7 USP9Y	8.74e-04	153	13	2	338684d420b01e32918fa19048ccdda234942ce1
ToppCell	severe_COVID-19-cDC\|World / disease group, cell group and cell class (v2)	FNIP2 FBN1	9.09e-04	156	13	2	0a7e18ed8e13261c405eb6b9a183e99d8e1aac37
ToppCell	droplet-Limb_Muscle-Pre-Sort-18m-Myeloid\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FNIP2 LRP2	9.20e-04	157	13	2	4862a11ab8df27d26b4f1c1785e544a2d5b6db6e
ToppCell	droplet-Limb_Muscle-Pre-Sort-18m-Myeloid-macrophage\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FNIP2 LRP2	9.20e-04	157	13	2	a0ec1628ce29841889f1d9d4ee9422921af7b0b5
ToppCell	droplet-Limb_Muscle-Pre-Sort-18m-Myeloid-nan\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FNIP2 LRP2	9.20e-04	157	13	2	c8f516d3f5622202d3f8514f68614cd86ea3f667
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRP2 FBN2	9.55e-04	160	13	2	c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRP2 FBN2	9.55e-04	160	13	2	25c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
ToppCell	ICU-SEP-Myeloid-cDC1\|ICU-SEP / Disease, Lineage and Cell Type	FNIP2 CABP1	9.67e-04	161	13	2	9fb73909fc2ec99f96ca2eed1a053bce89de7d16
ToppCell	Mild_COVID-19-Myeloid-MoAM2\|Mild_COVID-19 / Disease group,lineage and cell class （2021.01.30）	FNIP2 FBN2	9.79e-04	162	13	2	e5fc80ab19d513af6a7e677a5e67bfebca2e963b
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1-6_VIP_PENK\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	DEUP1 FBN2	9.91e-04	163	13	2	551b3788bcf494c6121e64ce5af72266de12a06b
ToppCell	normal_Lung-Fibroblasts-Myofibroblasts\|Fibroblasts / Location, Cell class and cell subclass	DEUP1 FBN2	1.00e-03	164	13	2	9b4a6007abae992db871d9f6f731d5af724de30d
ToppCell	droplet-Limb_Muscle-MUSCLE-30m-Lymphocytic-unknown\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CABP1 DEUP1	1.02e-03	165	13	2	475905d608fac628960188ae4a18010b8097417e
ToppCell	droplet-Pancreas-Endocrine-18m-Epithelial-nan\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FNIP2 CABP1	1.03e-03	166	13	2	66026988509e39e41274fa0de738383219e8ff30
ToppCell	368C-Myeloid-Monocyte-CD16+_Monocyte\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	LRP2 USP9Y	1.04e-03	167	13	2	dbd2b9f2f4ba7be5fdf8318094e6b078cb1d1c43
ToppCell	5'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Stromal_1_(ADAMDEC1+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FBN1 FBN2	1.06e-03	169	13	2	c0824a93674e2bff0f09b2d2fab5bab016a2e379
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c03-ITGA4\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	CABP1 TAF1	1.08e-03	170	13	2	adb625124832b0786a590e8f75b61e7263a1e0d4
ToppCell	368C-Myeloid-Monocyte-CD16+_Monocyte\|Monocyte / Donor, Lineage, Cell class and subclass (all cells)	LRP2 USP9Y	1.08e-03	170	13	2	4a19c7e3bb0f9c2601a10debe7000066789b4150
ToppCell	Bac-SEP-Myeloid-cDC1\|Bac-SEP / Disease, Lineage and Cell Type	FNIP2 FBN1	1.12e-03	173	13	2	f88269327441858ddb8c49b9dd619b76fd53b1da
ToppCell	droplet-Lung-immune-endo-depleted-3m-Myeloid-Myeloid_Dendritic_Type_1\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TAF1 NAGA	1.13e-03	174	13	2	ff13a5c55d18b951315908f33cb47c7f9cb901bf
ToppCell	facs-Aorta\|facs / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRP2 DEUP1	1.15e-03	176	13	2	0b3491451be02c18a16cdb875645be47eb867a7f
ToppCell	10x_5'_v1-Non-neoplastic-Myeloid-TAM-BDM-TAM-BDM_MHC\|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	FBN2 NAGA	1.18e-03	178	13	2	c90e9048fc786ba8559972ae25c25ecab4bc1b7c
ToppCell	10x_5'_v1-Non-neoplastic-Myeloid-TAM-BDM-TAM-BDM_MHC-Z\|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	FBN2 NAGA	1.18e-03	178	13	2	9e426ce23a4a33b91d139ad85685cf8483bcd01a
ToppCell	LPS-antiTNF\|World / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	FNIP2 USP9Y	1.18e-03	178	13	2	289d1425c4e57fabcca994b27f9af1c0ce5d5bec
ToppCell	3'-Broncho-tracheal-Immune_Myeloid-Myeloid_monocytic-non-classical_monocyte-Non-classical_monocytes-Non-classical_monocytes_L.1.2.2.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	NAGA USP9Y	1.18e-03	178	13	2	aa9f68a66e292f331faef881bbd0d028f0f2b0c5
ToppCell	droplet-Limb_Muscle-Pre-Sort\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRP2 CABP1	1.21e-03	180	13	2	af2bafcd1b2082629de3ea336711add01565c4c4
ToppCell	356C-Myeloid-Macrophage-SPP1+_Macrophage_2\|356C / Donor, Lineage, Cell class and subclass (all cells)	FNIP2 NAGA	1.21e-03	180	13	2	b94618c1c2592ecf7da3535294aee9243755247a
ToppCell	droplet-Limb_Muscle-Pre-Sort-18m\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRP2 CABP1	1.21e-03	180	13	2	f29a995cf6e1a1836ed68b73258d9370bf3d4434
ToppCell	wk_08-11-Mesenchymal-Fibroblast-Mesenchymal_2\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	FBN1 FBN2	1.22e-03	181	13	2	9b2d207dc9fc2228a1555ed360286bb7c2d988ff
ToppCell	3'-Pediatric_IBD-SmallIntestine-Hematopoietic-Myeloid-cDC1\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FNIP2 DEUP1	1.22e-03	181	13	2	84ca8c9c036478a6d3a2071919d09065455d417c
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	LRP2 FBN2	1.22e-03	181	13	2	6956ecd6264f7469a25e555673bce4eb97d28f7a
ToppCell	metastatic_Brain-Fibroblasts-Myofibroblasts\|metastatic_Brain / Location, Cell class and cell subclass	FBN1 FBN2	1.22e-03	181	13	2	bd0b5f74f9c81ec0f1592710774a4fdf33d9d5a9
ToppCell	droplet-Lung-21m-Endothelial-arterial_endothelial\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	DEUP1 FBN1	1.23e-03	182	13	2	d95635b74e8cd8bc00bfe40340806b59fb9bee43
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-3m-Mesenchymal-ependymal_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRP2 DEUP1	1.23e-03	182	13	2	587636c0f127231de21acd8aa632b74ff22ca8c2
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-3m-Mesenchymal-Ependyma\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRP2 DEUP1	1.23e-03	182	13	2	adfadd7893e74b3002f13f00875e3667d3493e0c
ToppCell	droplet-Lung-21m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	DEUP1 FBN1	1.23e-03	182	13	2	c7f2d24697affa530b748ab32b1d40bdc1bdc20a
ToppCell	3'-Child04-06-SmallIntestine-Hematopoietic-Myeloid-cDC1\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FNIP2 DEUP1	1.25e-03	183	13	2	8542040b7585842b89bb1329dae4029c1b7b5427
ToppCell	droplet-Lung-30m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l27\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	DEUP1 FBN1	1.25e-03	183	13	2	351d575339038bd4a66f408da518c567444208e8
ToppCell	3'-Child09-12-SmallIntestine-Hematopoietic-Myeloid-cDC1\|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FNIP2 DEUP1	1.25e-03	183	13	2	661bfc8f5f683b0f4c12bdd359e67c513b181678
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRP2 FBN2	1.26e-03	184	13	2	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRP2 FBN2	1.26e-03	184	13	2	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRP2 FBN2	1.26e-03	184	13	2	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	droplet-Lung-30m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	DEUP1 FBN1	1.26e-03	184	13	2	f506d0ee48f39d6f59f19554217dfdf0987cc405
ToppCell	Primary_Visual_cortex_(V1C)-Non-neuronal-Macroglial-Oligo\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	LRP2 CHD7	1.26e-03	184	13	2	a2191dd5546efd357b23e625beb3c5820476f243
ToppCell	droplet-Lung-30m-Endothelial-arterial_endothelial\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	DEUP1 FBN1	1.26e-03	184	13	2	8bcb1c4bc8ffef74338cdade926a94711de93c64
ToppCell	droplet-Fat-Scat-21m-Mesenchymal-Cd34+\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FBN1 FBN2	1.27e-03	185	13	2	01bbe1e09f9ccae837a03ea2cdd168fa10800942
ToppCell	Primary_Visual_cortex_(V1C)-Non-neuronal\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	LRP2 CHD7	1.27e-03	185	13	2	b5277190866d9eb5b85eceaa5ba116ea6e6f286b
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_Arw_fibro_(16)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	FBN1 FBN2	1.27e-03	185	13	2	7dcdc009c5681ee05dd18968f7e85c3403fe34af
ToppCell	droplet-Kidney-KIDNEY-1m-Mesenchymal-Stroma____fibroblast\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FBN1 FBN2	1.27e-03	185	13	2	785c55d39909fac74415f24427979691e7e694e6
ToppCell	droplet-Kidney-KIDNEY-1m-Mesenchymal\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FBN1 FBN2	1.27e-03	185	13	2	97a1dcacbc48dc3f41c26fbb59af35c935f894d4
ToppCell	PND07-28-samps-Mesenchymal-Myofibroblast-myofibroblast_-_mature_-_C\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	FBN1 FBN2	1.27e-03	185	13	2	427176ad9ab8d9511200fb0a132cfd1e835fe35c
ToppCell	droplet-Kidney-KIDNEY-30m-Epithelial-Pecam____Kidney_cortex_artery_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CABP1 FBN1	1.27e-03	185	13	2	f98af3146ec2f44c30d31a662fb9c4fa3ca4f706
ToppCell	P03-Mesenchymal-mesenchymal_fibroblast-mesenchymal_alveolar_niche_cell\|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	FBN1 FBN2	1.29e-03	186	13	2	c0a036096c2cb23305605b8aaf18869d6e0fb512
ToppCell	10x5'-Liver-Myeloid_Dendritic-DC1\|Liver / Manually curated celltypes from each tissue	FNIP2 NAGA	1.29e-03	186	13	2	e823529ffd06352c6bdec102f221fdf27f7c7369
ToppCell	droplet-Kidney-KIDNEY-1m-Mesenchymal-fibroblast\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FBN1 FBN2	1.29e-03	186	13	2	94d577dbb6bfacf50632e1fe8af041b35a1e6b23
ToppCell	PCW_07-8.5-Mesenchymal-Mesenchymal_fibroblastic-mes_Arw_fibro_(16)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	FBN1 FBN2	1.29e-03	186	13	2	4d68ee3d32f7ef884faf402ef92b31b0eb4656f1
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	LRP2 CABP1	1.29e-03	186	13	2	b1edc341d6684b347dc9e21b34f62f51d095d735
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_Arw_fibro_(16)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	FBN1 FBN2	1.30e-03	187	13	2	5258674d0346e5c51a4b965efcdc1790c970845d
ToppCell	Primary_Visual_cortex_(V1C)-Non-neuronal-Macroglial\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	LRP2 CHD7	1.30e-03	187	13	2	97e520705491c8f52a32025311a9fa7b9176979a
ToppCell	primary_auditory_cortex_(A1C)-Non-neuronal-Macroglial-Oligo-Oligodendrocyte\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	LRP2 CHD7	1.30e-03	187	13	2	b71d0cd91bc98e020757c1d071a13ad48d718bcf
ToppCell	5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(non-nasal)-Club_(non-nasal)_L.0.4.0.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	LRP2 CHD7	1.30e-03	187	13	2	f5a202d5f8eb57b57d80815ce98774e04c387383
ToppCell	Mesenchymal-chondrocyte\|World / Lineage, Cell type, age group and donor	FBN1 FBN2	1.31e-03	188	13	2	7b1e3f8a941eaa68e89c562129a92314642eec66
ToppCell	primary_auditory_cortex_(A1C)-Non-neuronal-Macroglial-Oligo\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	LRP2 CHD7	1.31e-03	188	13	2	b04fd6a724c117eb9a979c29b91f90113feb7a5c
ToppCell	Somatosensory_Cortex_(S1)-Non-neuronal-Macroglial-Oligo\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	LRP2 CHD7	1.31e-03	188	13	2	60242c29c7f16c94a84685d3bc4ed93a66e70152
ToppCell	droplet-Fat-Scat-21m-Mesenchymal-mesenchymal_stem_cell_of_adipose\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FBN1 FBN2	1.31e-03	188	13	2	e54e09d34e263d5709c337914809e61e74e20591
ToppCell	normal-na-Hematopoietic-progenitor_cell-female\|normal / PBMC cell types (v2) per disease, treatment status, and sex	LRP2 FBN1	1.31e-03	188	13	2	be25371e6459504b5f0c9ece3a0fe8f80c7824ca
ToppCell	droplet-Fat-Scat-21m-Mesenchymal\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FBN1 FBN2	1.31e-03	188	13	2	7fc9810ab14354cb512e2b1285562009c10203f5
ToppCell	normal-na-Hematopoietic-progenitor_cell\|normal / PBMC cell types (v2) per disease, treatment status, and sex	LRP2 FBN1	1.31e-03	188	13	2	013162466a3334b6967c0cb670c8577d809b1396
ToppCell	droplet-Pancreas-PANCREAS-30m-Mesenchymal-pancreatic_stellate_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FBN1 FBN2	1.33e-03	189	13	2	1821ae4a6e37ee4c6308071883f3f447a7c53c53
ToppCell	Fibroblast-C\|World / shred on cell class and cell subclass (v4)	FBN1 FBN2	1.33e-03	189	13	2	58e0400fbab5a0755504275aef5cf7986149abab
ToppCell	droplet-Pancreas-PANCREAS-30m-Mesenchymal\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FBN1 FBN2	1.33e-03	189	13	2	1dc415ed41815f4296dafd8cf7f3e014c44db1db
ToppCell	Somatosensory_Cortex_(S1)-Non-neuronal\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	LRP2 CHD7	1.33e-03	189	13	2	42ab4cc5fbf8580841f31889446fe4499df1a464
ToppCell	10x3'2.3-week_17-19-Mesenchymal_osteo-stroma-osteochondral_precursor\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	CABP1 FBN1	1.33e-03	189	13	2	1ff4f8da572bdc6356e9df9f41a7f62c81d4c570
ToppCell	droplet-Pancreas-PANCREAS-30m-Mesenchymal-pancreatic_stellate_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FBN1 FBN2	1.33e-03	189	13	2	1e4d7e8dc98b3d70351e6a6c2aaf9ca01f141b8f
ToppCell	Primary_Motor_Cortex_(M1)-Non-neuronal-Macroglial-Oligo\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	LRP2 CHD7	1.33e-03	189	13	2	70eea8c94fa56bb15bee8065de47acea156794e9
ToppCell	RV-15._Ventricular_Cardiomyocyte_III\|World / Chamber and Cluster_Paper	FNIP2 FBN2	1.33e-03	189	13	2	0a82931b5f6c0a6427ca3edd5e2235ac49099d40
ToppCell	PND01-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_mature\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FBN1 FBN2	1.34e-03	190	13	2	947807863a9b247c301c6cf63d6fd5a2c8018e66
ToppCell	Somatosensory_Cortex_(S1)-Non-neuronal-Macroglial\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	LRP2 CHD7	1.34e-03	190	13	2	07f21386ea6eb23416a537d2250e3042efe93fb0
ToppCell	Primary_Motor_Cortex_(M1)-Non-neuronal-Macroglial\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	LRP2 CHD7	1.34e-03	190	13	2	ae97df1b06bcd46c05759b53c35dc8fea97f4ac1
ToppCell	Mid-temporal_gyrus_(MTG)-Non-neuronal-Macroglial-Oligo\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	LRP2 CHD7	1.36e-03	191	13	2	2110a1dd10730ad7ee7a265fb1716ab3ddafcf4a
ToppCell	saliva-Mild-Moderate_progression_d12-25-Myeloid-Dendritic-conventional_dendritic_cell-DC_c2-CD1C\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	FNIP2 NAGA	1.36e-03	191	13	2	5c0c44612b4cdbf89c0f1f219416374a7541f610
ToppCell	E18.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FBN1 FBN2	1.36e-03	191	13	2	4b50fdd310701251e64e16cd2d07ce03dbfd3e3e
ToppCell	PND01-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FBN1 FBN2	1.36e-03	191	13	2	db4943dd19207663fb9e27f8940fa4b06a933625
ToppCell	E18.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_mature\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FBN1 FBN2	1.36e-03	191	13	2	75d2197076a9dfc868e8baf95bd4c5e44f438e3e
ToppCell	ILEUM-inflamed-(3)_DC1\|inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	FNIP2 NAGA	1.36e-03	191	13	2	e77a6cace0d5a0463ad770e1b73fabbcb6f2d45f
ToppCell	droplet-Kidney-KIDNEY-1m-Epithelial-Pecam____Kidney_cortex_artery_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CABP1 FBN1	1.36e-03	191	13	2	b9ae5af426e7a1f2652a47700bb168371bd2dec6
ToppCell	E16.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-VSMC\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CABP1 FBN1	1.36e-03	191	13	2	9431ffd6b758f756609d9057de2023596e22b5d4
ToppCell	Primary_Motor_Cortex_(M1)-Non-neuronal\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	LRP2 CHD7	1.36e-03	191	13	2	2b056cbe2e82e056e1f798974999378460eb1d16
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Epithelial-mature_enterocytic-Colonocyte\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FNIP2 DEUP1	1.37e-03	192	13	2	1a3d95a9801cc4569b67fa652b2af46c4dedbaef
ToppCell	5'-GW_trimst-2-LargeIntestine-Mesenchymal-immature_mesenchymal_cell-Mesoderm_2_(ZEB2+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FBN1 FBN2	1.37e-03	192	13	2	f053b89bfd6048c227667ff01c38df7c51d8a496
Drug	TAAD	FBN1 FBN2	6.28e-05	21	13	2	CID000133445
Drug	rosavin	FBN1 FBN2	1.48e-04	32	13	2	ctd:C529148
Drug	isodesmosine	FBN1 FBN2	1.57e-04	33	13	2	CID000013811
Drug	NSC49080	FBN1 FBN2	1.57e-04	33	13	2	CID000002192
Drug	Terconazole [67915-31-5]; Up 200; 7.6uM; MCF7; HT_HG-U133A	LRP2 TAF1 USP9Y	1.64e-04	194	13	3	2844_UP
Drug	Gliclazide [21187-98-4]; Down 200; 12.4uM; PC3; HT_HG-U133A	TAF1 FBN1 FBN2	1.66e-04	195	13	3	5089_DN
Drug	Ketoconazole [65277-42-1]; Down 200; 7.6uM; PC3; HT_HG-U133A	CABP1 CHD7 FBN1	1.69e-04	196	13	3	4624_DN
Drug	Chloropyramine hydrochloride [6170-42-9]; Up 200; 12.2uM; MCF7; HT_HG-U133A	FBN1 FBN2 USP9Y	1.74e-04	198	13	3	4414_UP
Drug	(S)-(-)-Atenolol [93379-54-5]; Up 200; 15uM; MCF7; HT_HG-U133A	LRP2 CABP1 TAF1	1.76e-04	199	13	3	6444_UP
Disease	connective tissue disease (implicated_via_orthology)	FBN1 FBN2	4.55e-07	3	12	2	DOID:65 (implicated_via_orthology)
Disease	scoliosis (is_implicated_in)	FBN1 FBN2	9.09e-07	4	12	2	DOID:0060249 (is_implicated_in)
Disease	Familial thoracic aortic aneurysm and aortic dissection	FBN1 FBN2	2.07e-04	53	12	2	C4707243
Disease	congenital heart disease (implicated_via_orthology)	LRP2 CHD7	3.50e-04	69	12	2	DOID:1682 (implicated_via_orthology)
Disease	Intellectual Disability	LRP2 TAF1 TBC1D23	6.86e-04	447	12	3	C3714756
Disease	cortical thickness	FNIP2 CHD7 FBN1 FBN2	7.82e-04	1113	12	4	EFO_0004840
Disease	ocular sarcoidosis	LRP2 FBN2	9.86e-04	116	12	2	EFO_0010723

Protein segments in the cluster

Peptide	Gene	Start	Entry
GMMGDLDPGEYMSMD	DEUP1	431	Q05D60
GNCMRTMGYMPTEME	CABP1	251	Q9NZU7
MQQMGSYMARGDFSM	CHD7	186	Q9P2D1
YDVMGMGRMEMELDY	GPATCH8	76	Q9UKJ3
MGRMEMELDYAEDAT	GPATCH8	81	Q9UKJ3
DRSMAMSEDFVMEMG	LRP2	4501	P98164
YESGFMMMKNCMDID	FBN1	1101	P35555
NMLGEMMFGSVAMSY	FNIP2	136	Q9P278
YESGFMMMKNCMDID	FBN2	1146	P35556
MDMENEESMMSYEGD	TAF1	1771	P21675
MGSGREEEDMYMNMV	TBC1D23	401	Q9NUY8
EYMGEVFDHMMKRMS	USP9Y	1926	O00507
MDGGMDLNMEQGMAE	TMEM208	86	Q9BTX3
MEMADRMAQDGWRDM	NAGA	56	P17050