Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	histone H3K9me2/H3K9me3 demethylase activity	KDM4C KDM4B	5.86e-06	6	13	2	GO:0140684
GeneOntologyMolecularFunction	histone H3K36 demethylase activity	KDM4C KDM4B	2.14e-05	11	13	2	GO:0051864
GeneOntologyMolecularFunction	histone H3K9 demethylase activity	KDM4C KDM4B	3.54e-05	14	13	2	GO:0032454
GeneOntologyMolecularFunction	histone H3 demethylase activity	KDM4C KDM4B	1.46e-04	28	13	2	GO:0141052
GeneOntologyMolecularFunction	histone demethylase activity	KDM4C KDM4B	1.80e-04	31	13	2	GO:0032452
GeneOntologyMolecularFunction	protein demethylase activity	KDM4C KDM4B	1.92e-04	32	13	2	GO:0140457
GeneOntologyMolecularFunction	demethylase activity	KDM4C KDM4B	3.64e-04	44	13	2	GO:0032451
GeneOntologyMolecularFunction	histone modifying activity	KDM4C HDAC11 KDM4B	3.91e-04	229	13	3	GO:0140993
GeneOntologyMolecularFunction	2-oxoglutarate-dependent dioxygenase activity	KDM4C KDM4B	7.95e-04	65	13	2	GO:0016706
GeneOntologyMolecularFunction	dioxygenase activity	KDM4C KDM4B	1.80e-03	98	13	2	GO:0051213
GeneOntologyMolecularFunction	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	KDM4C KDM4B	6.83e-03	194	13	2	GO:0016705
GeneOntologyCellularComponent	pericentric heterochromatin	KDM4C KDM4B	1.48e-04	32	12	2	GO:0005721
GeneOntologyCellularComponent	heterochromatin	KDM4C KDM4B	1.48e-03	101	12	2	GO:0000792
Domain	CRA	RANBP9 RANBP10	6.70e-06	6	13	2	SM00757
Domain	CTLH/CRA	RANBP9 RANBP10	6.70e-06	6	13	2	IPR024964
Domain	CRA_dom	RANBP9 RANBP10	6.70e-06	6	13	2	IPR013144
Domain	CLTH	RANBP9 RANBP10	6.70e-06	6	13	2	PF10607
Domain	LisH	RANBP9 RANBP10	1.61e-05	9	13	2	PF08513
Domain	CTLH	RANBP9 RANBP10	1.61e-05	9	13	2	SM00668
Domain	JmjN	KDM4C KDM4B	2.01e-05	10	13	2	PF02375
Domain	CTLH	RANBP9 RANBP10	2.01e-05	10	13	2	PS50897
Domain	CTLH_C	RANBP9 RANBP10	2.01e-05	10	13	2	IPR006595
Domain	JMJN	KDM4C KDM4B	2.01e-05	10	13	2	PS51183
Domain	JmjN	KDM4C KDM4B	2.01e-05	10	13	2	IPR003349
Domain	JmjN	KDM4C KDM4B	2.01e-05	10	13	2	SM00545
Domain	EPHD	KDM4C KDM4B	1.03e-04	22	13	2	PS51805
Domain	TUDOR	KDM4C KDM4B	1.12e-04	23	13	2	PS50304
Domain	JmjC	KDM4C KDM4B	1.22e-04	24	13	2	PF02373
Domain	TUDOR	KDM4C KDM4B	1.55e-04	27	13	2	SM00333
Domain	LisH	RANBP9 RANBP10	1.67e-04	28	13	2	IPR006594
Domain	LISH	RANBP9 RANBP10	1.67e-04	28	13	2	PS50896
Domain	LisH	RANBP9 RANBP10	1.67e-04	28	13	2	SM00667
Domain	Tudor	KDM4C KDM4B	1.92e-04	30	13	2	IPR002999
Domain	JMJC	KDM4C KDM4B	2.19e-04	32	13	2	PS51184
Domain	JmjC_dom	KDM4C KDM4B	2.19e-04	32	13	2	IPR003347
Domain	JmjC	KDM4C KDM4B	2.33e-04	33	13	2	SM00558
Domain	SPRY	RANBP9 RANBP10	1.62e-03	87	13	2	SM00449
Domain	PHD	KDM4C KDM4B	1.69e-03	89	13	2	SM00249
Domain	Znf_PHD	KDM4C KDM4B	1.77e-03	91	13	2	IPR001965
Domain	SPRY	RANBP9 RANBP10	1.89e-03	94	13	2	PF00622
Domain	SPRY_dom	RANBP9 RANBP10	1.89e-03	94	13	2	IPR003877
Domain	ZF_PHD_2	KDM4C KDM4B	1.93e-03	95	13	2	PS50016
Domain	B30.2/SPRY	RANBP9 RANBP10	1.93e-03	95	13	2	IPR001870
Domain	B302_SPRY	RANBP9 RANBP10	1.93e-03	95	13	2	PS50188
Domain	ZF_PHD_1	KDM4C KDM4B	1.97e-03	96	13	2	PS01359
Domain	Znf_FYVE_PHD	KDM4C KDM4B	4.53e-03	147	13	2	IPR011011
Domain	ConA-like_dom	RANBP9 RANBP10	9.80e-03	219	13	2	IPR013320
Pathway	REACTOME_MET_ACTIVATES_RAS_SIGNALING	RANBP9 RANBP10	3.52e-05	10	13	2	MM15488
Pathway	REACTOME_MET_ACTIVATES_RAS_SIGNALING	RANBP9 RANBP10	4.30e-05	11	13	2	M27740
Pathway	REACTOME_HDMS_DEMETHYLATE_HISTONES	KDM4C KDM4B	3.14e-04	29	13	2	MM14934
Pathway	REACTOME_HDMS_DEMETHYLATE_HISTONES	KDM4C KDM4B	9.38e-04	50	13	2	M27232
Pathway	PID_AR_PATHWAY	RANBP9 KDM4C	1.39e-03	61	13	2	M58
Pathway	REACTOME_SIGNALING_BY_MET	RANBP9 RANBP10	1.68e-03	67	13	2	MM15345
Pathway	PID_MET_PATHWAY	RANBP9 RANBP10	2.32e-03	79	13	2	M48
Pathway	REACTOME_SIGNALING_BY_MET	RANBP9 RANBP10	2.32e-03	79	13	2	M27643
Pubmed	Distinct and combinatorial functions of Jmjd2b/Kdm4b and Jmjd2c/Kdm4c in mouse embryonic stem cell identity.	KDM4C KDM4B	1.29e-07	2	13	2	24361252
Pubmed	Comparative integromics on JMJD2A, JMJD2B and JMJD2C: preferential expression of JMJD2C in undifferentiated ES cells.	KDM4C KDM4B	3.87e-07	3	13	2	17611647
Pubmed	Histone demethylase JMJD2B and JMJD2C induce fibroblast growth factor 2: mediated tumorigenesis of osteosarcoma.	KDM4C KDM4B	3.87e-07	3	13	2	25636512
Pubmed	Continual removal of H3K9 promoter methylation by Jmjd2 demethylases is vital for ESC self-renewal and early development.	KDM4C KDM4B	3.87e-07	3	13	2	27266524
Pubmed	The histone demethylase JMJD2C is stage-specifically expressed in preimplantation mouse embryos and is required for embryonic development.	KDM4C KDM4B	3.87e-07	3	13	2	19696013
Pubmed	The KDM4/JMJD2 histone demethylases are required for hematopoietic stem cell maintenance.	KDM4C KDM4B	3.87e-07	3	13	2	31434704
Pubmed	The histone demethylase Kdm4 suppresses activation of hepatic stellate cell by inducing MiR-29 transcription.	KDM4C KDM4B	7.74e-07	4	13	2	31014673
Pubmed	Regulation of Jumonji-domain-containing histone demethylases by hypoxia-inducible factor (HIF)-1alpha.	KDM4C KDM4B	7.74e-07	4	13	2	18713068
Pubmed	Activation of Ras/Erk pathway by a novel MET-interacting protein RanBPM.	RANBP9 RANBP10	7.74e-07	4	13	2	12147692
Pubmed	Jmjd2/Kdm4 demethylases are required for expression of Il3ra and survival of acute myeloid leukemia cells.	KDM4C KDM4B	7.74e-07	4	13	2	27257215
Pubmed	Jmjd2b antagonizes H3K9 trimethylation at pericentric heterochromatin in mammalian cells.	KDM4C KDM4B	1.29e-06	5	13	2	16738407
Pubmed	Structural and evolutionary basis for the dual substrate selectivity of human KDM4 histone demethylase family.	KDM4C KDM4B	1.29e-06	5	13	2	21914792
Pubmed	Identification and characterization of JMJD2 family genes in silico.	KDM4C KDM4B	1.93e-06	6	13	2	15138608
Pubmed	Histone demethylase JMJD2B functions as a co-factor of estrogen receptor in breast cancer proliferation and mammary gland development.	KDM4C KDM4B	2.71e-06	7	13	2	21445275
Pubmed	Potent and Selective KDM5 Inhibitor Stops Cellular Demethylation of H3K4me3 at Transcription Start Sites and Proliferation of MM1S Myeloma Cells.	KDM4C KDM4B	2.71e-06	7	13	2	28262558
Pubmed	YPEL5 protein of the YPEL gene family is involved in the cell cycle progression by interacting with two distinct proteins RanBPM and RanBP10.	RANBP9 RANBP10	5.79e-06	10	13	2	20580816
Pubmed	Deletion of JMJD2B in neurons leads to defective spine maturation, hyperactive behavior and memory deficits in mouse.	KDM4C KDM4B	5.79e-06	10	13	2	27023172
Pubmed	Dynamic Histone H1 Isotype 4 Methylation and Demethylation by Histone Lysine Methyltransferase G9a/KMT1C and the Jumonji Domain-containing JMJD2/KDM4 Proteins.	KDM4C KDM4B	7.08e-06	11	13	2	19144645
Pubmed	Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylases.	KDM4C KDM4B	1.17e-05	14	13	2	16603238
Pubmed	Identification of RanBP 9/10 as interacting partners for protein kinase C (PKC) gamma/delta and the D1 dopamine receptor: regulation of PKC-mediated receptor phosphorylation.	RANBP9 RANBP10	1.75e-05	17	13	2	20395553
Pubmed	The Epigenetic Factor Landscape of Developing Neocortex Is Regulated by Transcription Factors Pax6→ Tbr2→ Tbr1.	KDM4C HDAC11 KDM4B	2.50e-05	157	13	3	30186101
Pubmed	Broad histone H3K4me3 domains in mouse oocytes modulate maternal-to-zygotic transition.	KDM4C KDM4B	2.70e-05	21	13	2	27626377
Pubmed	Zfp296 negatively regulates H3K9 methylation in embryonic development as a component of heterochromatin.	KDM4C KDM4B	2.97e-05	22	13	2	28963472
Pubmed	Global mapping of herpesvirus-host protein complexes reveals a transcription strategy for late genes.	RANBP9 NHSL1 RANBP10 TAOK3	3.49e-05	533	13	4	25544563
Pubmed	Single-cell profiling of epigenetic modifiers identifies PRDM14 as an inducer of cell fate in the mammalian embryo.	KDM4C KDM4B	1.21e-04	44	13	2	24183668
Pubmed	Identification of Jmjd3 as an Essential Epigenetic Regulator of Hox Gene Temporal Collinear Activation for Body Axial Patterning in Mice.	KDM4C KDM4B	1.50e-04	49	13	2	34368113
Pubmed	Mitochondrial Raf1 Regulates Glutamine Catabolism.	NHSL1 RANBP10 HRNR	1.51e-04	288	13	3	38496616
Pubmed	New nomenclature for chromatin-modifying enzymes.	KDM4C KDM4B	2.03e-04	57	13	2	18022353
Interaction	GLIPR1L2 interactions	RANBP9 RANBP10	8.01e-05	21	13	2	int:GLIPR1L2
Interaction	CSTA interactions	KDM4C CTSO HRNR	8.36e-05	137	13	3	int:CSTA
Interaction	DRD1 interactions	RANBP9 RANBP10	9.64e-05	23	13	2	int:DRD1
Interaction	LECT2 interactions	RANBP9 RANBP10	1.05e-04	24	13	2	int:LECT2
Interaction	INSL6 interactions	RANBP9 RANBP10	1.14e-04	25	13	2	int:INSL6
Interaction	GDNF interactions	RANBP9 RANBP10	1.24e-04	26	13	2	int:GDNF
Interaction	SPON1 interactions	RANBP9 RANBP10	1.34e-04	27	13	2	int:SPON1
Interaction	CCDC120 interactions	RANBP9 RANBP10 KRTAP13-3	1.56e-04	169	13	3	int:CCDC120
Interaction	IL17F interactions	RANBP9 RANBP10	1.77e-04	31	13	2	int:IL17F
Interaction	GCG interactions	RANBP9 RANBP10	1.77e-04	31	13	2	int:GCG
Interaction	TCEAL9 interactions	RANBP9 RANBP10	1.77e-04	31	13	2	int:TCEAL9
Interaction	NMB interactions	RANBP9 RANBP10	2.01e-04	33	13	2	int:NMB
Interaction	WNT10A interactions	RANBP9 RANBP10	2.53e-04	37	13	2	int:WNT10A
Interaction	CHRDL2 interactions	RANBP9 RANBP10	2.95e-04	40	13	2	int:CHRDL2
Interaction	GNLY interactions	RANBP9 RANBP10	2.95e-04	40	13	2	int:GNLY
Interaction	FBXO22 interactions	KDM4C ZFR TAOK3 KDM4B	3.01e-04	540	13	4	int:FBXO22
Interaction	MMP7 interactions	RANBP9 RANBP10	3.91e-04	46	13	2	int:MMP7
Interaction	PRG3 interactions	RANBP9 RANBP10	4.44e-04	49	13	2	int:PRG3
Interaction	RMND5B interactions	RANBP9 RANBP10	4.44e-04	49	13	2	int:RMND5B
Interaction	GCH1 interactions	RANBP9 RANBP10	7.34e-04	63	13	2	int:GCH1
Interaction	KDM4A interactions	KDM4C KDM4B	7.57e-04	64	13	2	int:KDM4A
Interaction	KCTD6 interactions	RANBP9 RANBP10	8.79e-04	69	13	2	int:KCTD6
Interaction	CRIPTO interactions	RANBP9 RANBP10	8.79e-04	69	13	2	int:CRIPTO
Interaction	GDF15 interactions	RANBP9 RANBP10	9.05e-04	70	13	2	int:GDF15
Interaction	KDM4B interactions	KDM4C KDM4B	9.31e-04	71	13	2	int:KDM4B
Interaction	YPEL5 interactions	RANBP9 RANBP10	1.01e-03	74	13	2	int:YPEL5
Interaction	PRICKLE3 interactions	RANBP9 RANBP10	1.01e-03	74	13	2	int:PRICKLE3
Interaction	GID4 interactions	RANBP9 RANBP10	1.01e-03	74	13	2	int:GID4
Interaction	KDM4C interactions	KDM4C KDM4B	1.07e-03	76	13	2	int:KDM4C
Interaction	CBFA2T3 interactions	RANBP9 RANBP10	1.12e-03	78	13	2	int:CBFA2T3
Interaction	LGALS3 interactions	RANBP9 HRNR CUBN	1.20e-03	340	13	3	int:LGALS3
GeneFamily	PHD finger proteins\|Lysine demethylases	KDM4C KDM4B	4.71e-05	24	8	2	485
GeneFamily	Tudor domain containing	KDM4C KDM4B	1.13e-04	37	8	2	780
Coexpression	GSE6259_FLT3L_INDUCED_DEC205_POS_DC_VS_CD4_TCELL_UP	RANBP9 CTSO TAOK3	6.45e-05	163	13	3	M6763
Coexpression	GSE21033_3H_VS_24H_POLYIC_STIM_DC_UP	KDM4C RANBP10 KDM4B	6.81e-05	166	13	3	M7722
Coexpression	GSE15624_3H_VS_6H_HALOFUGINONE_TREATED_CD4_TCELL_UP	CTSO TAOK3 KDM4B	7.44e-05	171	13	3	M7105
Drug	Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; PC3; HG-U133A	RANBP10 TAOK3 KDM4B	1.25e-04	177	13	3	1951_UP
Drug	Fenoprofen calcium salt dihydrate [53746-45-5]; Down 200; 7.2uM; MCF7; HT_HG-U133A	KDM4C RANBP10 ZFR	1.61e-04	193	13	3	3412_DN
Drug	Suloctidil [54063-56-8]; Down 200; 11.8uM; HL60; HT_HG-U133A	RANBP10 ZFR KDM4B	1.61e-04	193	13	3	1297_DN
Drug	Hydrastine hydrochloride [5936-28-7]; Up 200; 9.6uM; PC3; HT_HG-U133A	KDM4C HDAC11 ZFR	1.66e-04	195	13	3	7309_UP
Drug	Clomiphene citrate (Z,E) [50-41-9]; Up 200; 6.6uM; MCF7; HT_HG-U133A	KDM4C RANBP10 HDAC11	1.66e-04	195	13	3	2624_UP
Drug	radicicol; Up 200; 0.1uM; MCF7; HG-U133A	RANBP10 ZFR KDM4B	1.66e-04	195	13	3	325_UP
Drug	Ganciclovir [82410-32-0]; Down 200; 15.6uM; PC3; HT_HG-U133A	RANBP9 RANBP10 KDM4B	1.71e-04	197	13	3	6289_DN
Drug	Sulfadiazine [68-35-9]; Up 200; 16uM; MCF7; HT_HG-U133A	KDM4C HDAC11 ZFR	1.74e-04	198	13	3	1688_UP
Drug	Spironolactone [52-01-7]; Up 200; 9.6uM; HL60; HG-U133A	RANBP9 KDM4C ZFR	1.74e-04	198	13	3	1380_UP
Drug	GSK-3 Inhibitor IX; Down 200; 0.5uM; MCF7; HT_HG-U133A	RANBP9 HDAC11 KDM4B	1.74e-04	198	13	3	6589_DN
Drug	nitrendipine; Down 200; 10uM; MCF7; HG-U133A	HDAC11 KDM4B CUBN	1.74e-04	198	13	3	336_DN
Drug	Terazosin hydrochloride [63590-64-7]; Down 200; 9.4uM; HL60; HT_HG-U133A	KDM4C CTSO KDM4B	1.76e-04	199	13	3	2530_DN
Drug	Doxycycline hydrochloride [10592-13-9]; Down 200; 8.4uM; PC3; HT_HG-U133A	RANBP10 ZFR CTSO	1.76e-04	199	13	3	5838_DN
Drug	Epirizole [18694-40-1]; Down 200; 17uM; MCF7; HT_HG-U133A	KDM4C RANBP10 ZFR	1.79e-04	200	13	3	1681_DN
Disease	medulloblastoma (is_marker_for)	KDM4C KDM4B	1.79e-06	5	13	2	DOID:0050902 (is_marker_for)
Disease	alopecia areata (is_marker_for)	KDM4C KDM4B	8.05e-06	10	13	2	DOID:986 (is_marker_for)
Disease	melanoma	KDM4C KDM4B CUBN	1.58e-04	248	13	3	C0025202
Disease	Medullomyoblastoma	KDM4C KDM4B	1.60e-04	43	13	2	C0205833
Disease	Adult Medulloblastoma	KDM4C KDM4B	1.60e-04	43	13	2	C0278876
Disease	Childhood Medulloblastoma	KDM4C KDM4B	1.60e-04	43	13	2	C0278510
Disease	Desmoplastic Medulloblastoma	KDM4C KDM4B	1.60e-04	43	13	2	C0751291
Disease	Melanotic medulloblastoma	KDM4C KDM4B	1.60e-04	43	13	2	C1275668
Disease	Medulloblastoma	KDM4C KDM4B	2.17e-04	50	13	2	C0025149
Disease	complement factor D measurement	KDM4C KIR2DL1	7.49e-04	93	13	2	EFO_0020283
Disease	corneal topography	NHSL1 HDAC11	1.03e-03	109	13	2	EFO_0004345
Disease	breast cancer (is_implicated_in)	KDM4C KDM4B	1.93e-03	150	13	2	DOID:1612 (is_implicated_in)
Disease	prostate cancer (is_marker_for)	KDM4C KDM4B	2.08e-03	156	13	2	DOID:10283 (is_marker_for)
Disease	Hypermetropia, Myopia	KDM4C CUBN	3.04e-03	189	13	2	HP_0000540, HP_0000545
Disease	systemic lupus erythematosus	KDM4C TAOK3 KDM4B	4.62e-03	799	13	3	MONDO_0007915
Disease	opioid dependence	RANBP9 NHSL1	4.73e-03	237	13	2	EFO_0005611
Disease	mean arterial pressure	TAOK3 KDM4B	1.97e-02	499	13	2	EFO_0006340

Protein segments in the cluster

Peptide	Gene	Start	Entry
FHHCSSDRGGGFCAY	HDAC11	141	Q96DB2
SYGYHGDDGHSFCSS	RANBP9	251	Q96S59
GYHGDDGHSFCSSGT	RANBP10	141	Q6VN20
YCASVHTDSGHGSGN	NHSL1	611	Q5SYE7
AYSQHGSGSGHFCSQ	HRNR	1296	Q86YZ3
AYSQHGSGSGHFCSQ	HRNR	1766	Q86YZ3
AYSQHGSGSGHFCSQ	HRNR	2236	Q86YZ3
AYSQHGSGSGHFCSQ	HRNR	2706	Q86YZ3
YHAGFNHGFNCAEST	KDM4B	276	O94953
GYHAGFNHGFNCAES	KDM4C	276	Q9H3R0
GNGHFCGSHASSTLF	CUBN	2171	O60494
CSRNFSSCSHGGYLH	KRTAP13-3	6	Q3SY46
THGGTYRCFGSFHDS	KIR2DL1	191	P43626
GHGSFGAVYFATNAH	TAOK3	31	Q9H2K8
NGLCHYFSGSHSGFS	CTSO	201	P43234
GNYFGFTHSGAAAAA	ZFR	26	Q96KR1